Elena A.
Elena A. Dibikovskaya, Richmond, CA US
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20110160146 | Conjungation of Small Molecules to Octaarginine Transporters for Overcoming Multi-Drug Resistance - Many cancer therapeutic agents elicit resistance that renders them ineffective and often produces cross resistance to other drugs. One of the most common mechanisms of resistance involves P-glycoprotein (Pgp) mediated drug efflux. Here we provide compositions and methods that restore the efficacy of a therapeutic agent reduced by resistance by conjugation of the same agent to an oligoarginine transporter comprising from about 5 to about 25 guanidino or amidino moieties. We specifically show that the widely used chemotherapeutic agent taxol, ineffective against taxol-resistant human ovarian cancer cell lines, can be incorporated into an octaarginine conjugate that is effective against the same taxol-resistant cell lines. Significantly, the ability of the taxol conjugates to overcome taxol resistance is observed both in cell culture and in animal models of ovarian cancer. The generality and mechanistic basis for this effect were also explored with other Pgp substrate. This approach shows generality for overcoming the multidrug resistance elicited by small molecule cancer chemotherapeutics and could improve the prognosis for many cancer patients and fundamentally alter search strategies for novel therapeutic agents effective against resistant disease. | 06-30-2011 |
Elena A. Dubikovskaya, Richmond, CA US
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20130315829 | Compounds and Methods for Detecting Reactive Oxygen Species - The present disclosure provides compounds that detect reactive oxygen species in a living cell, in a multicellular organism, or in a cell-free sample. The compounds find use in a variety of applications, which are also provided. The present disclosure provides compositions comprising a subject compound. | 11-28-2013 |
20140199239 | Compositions and Methods for in Vivo Imaging - The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided. | 07-17-2014 |
20150343094 | COMPOSITIONS AND METHODS FOR IN VIVO IMAGING - The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided. | 12-03-2015 |
Elena A. Dubikovskaya, Lausanne CH
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20130287699 | Luciferin Derivatives from Bicyclic Reactants and Aminothiol Derivatives and Methods of Use Thereof - The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided. | 10-31-2013 |
Elena A. Fedorovskaya, Rochester, NY US
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20100328492 | METHOD AND APPARATUS FOR IMAGE DISPLAY CONTROL ACCORDING TO VIEWER FACTORS AND RESPONSES - A device and system and a method for selecting and displaying images in accordance with attention responses of an image viewer. An image capture device captures a viewer image of a spatial region potentially containing a viewer of the image display device and a viewer detection mechanism analyzes the viewer image and determines whether a potential viewer is observing the display screen. A gaze pattern_analysis mechanism identifies a viewer response to a currently displayed image by analysis of the viewer's emotional response as revealed by the viewer's facial expression and other sensory inputs, and the selection of an image to be displayed is then modified in accordance with the indicated viewer's attention response. | 12-30-2010 |
Elena A. Glazkova, Tomsk RU
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20160074325 | Low-Dimensional Structures of Organic and/or Inorganic Substances and Use Thereof - The object of the present invention is low-dimensional, primarily 2D folded structures of organic and/or inorganic substances and/or their agglomerates, which have folds and faces of irregular shape and exhibit high local electric field strength generated by surface charges on the said folds, faces and edges, and use thereof: as sorbents of organic particles (molecules, bacteria, viruses, proteins, antigens, endotoxins) and inorganic particles (metal ions, colloids); as an agent with wound healing and antibacterial activity; as an agent for tumor cell growth inhibition. | 03-17-2016 |
Elena A. Goun, Stanford, CA US
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20100255499 | COMPOSITIONS AND METHODS FOR TRANSPORT OF MOLECULES WITH ENHANCED RELEASE PROPERTIES ACROSS BIOLOGICAL BARRIERS - Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the conjugate can be a biologically active agent or a reporter molecule. The transporter modulates the transport of the cargo across a biological barrier (e.g., a cell membrane) compared to the transport of the unconjugated cargo. Releasable linkers suitable for rapid and facile conjugation to various types of cargo and transporters are also disclosed, along with methods for using the linkers in the synthesis of conjugates. | 10-07-2010 |
Elena A. Govorkova, Cordova, TN US
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20110104202 | Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency - The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines. | 05-05-2011 |
20130017216 | Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency - The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines. | 01-17-2013 |
20140030702 | MODIFIED INFLUENZA VIRUS FOR MONITORING AND IMPROVING VACCINE EFFICIENCY - The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines. | 01-30-2014 |
Elena A. Grinev, Brookline, MA US
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20140282456 | METHODS, SYSTEMS AND COMPUTER-READABLE MEDIA FOR CODE PROFILING AND MIGRATION EFFORT ESTIMATION - Systems, methods and computer-readable storage media for profiling software and providing migration effort estimations are described. A software profiling system may be configured to receive code for an application that executes in a first computing environment and analyze the code to determine efforts associated with migrating the application to execute in one or more second computing environments. For instance, the software profiling system may be configured to determine the migration efforts for migrating a software application that operates in a non-cloud computing environment to a cloud computing environment. The software profiling system may generate transformation points that serve as estimation units for solving anomalies identified to bring various aspects of the application into conformance with one or more of the second computing environments. The transformation points may be used to determine an overall migration effort for migrating the application to one or more of the second computing environments. | 09-18-2014 |
Elena A. Guliants, Beavercreek, OH US
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20150266730 | METHOD OF GENERATING HYDROGEN FROM THE REACTION OF STABILIZED ALUMINUM NANOPARTICLES WITH WATER AND METHOD OF FORMING STABILIZED ALUMINUM NANOPARTICLES - A method of generating hydrogen gas from the reaction of stabilized aluminum nanoparticles with water is provided. The stabilized aluminum nanoparticles are synthesized from decomposition of an alane precursor in the presence of a catalyst and an organic passivation agent, and exhibit stability in air and solvents but are reactive with water. The reaction of the aluminum nanoparticles with water produces a hydrogen yield of at least 85%. | 09-24-2015 |
Elena A. Koryakina, Moscow RU
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20150161151 | METHOD AND SYSTEM FOR CREATION, ANALYSIS AND NAVIGATION OF VIRTUAL SNAPSHOTS - A method for generation of virtual images on a computer system having a Virtual Machine (VM), including (a) generating a virtual image of the VM that includes a state of the VM's disk at a particular moment in time; wherein the virtual image is viewable via a host-side graphical representation component for viewing a history of virtual images representing states of the VM's disk at prior moments in time; (b) storing the virtual image as multiple chunks or partitions; (c) from the host side, acquiring a state of the VM's memory using a guest-side Application Process Interface (API) and adding the state of the VM's memory to the virtual image; (d) configuring the graphical representation component to display only selected virtual images based on user selection, and (e) in the graphical representation component, displaying a representation of differences between at least two of the virtual images. | 06-11-2015 |
Elena A. Novakovskaia, Chappaqua, NY US
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20110208483 | METHOD FOR DESIGNING THE LAYOUT OF TURBINES IN A WINDFARM - A method and system for designing a layout of turbines on a grid is provided. The method comprises receiving wind data for each possible location of placement of a turbine on said grid; calculating an energy yield for a given layout of turbines on said grid as a nonlinear objective function, said function constrained by said wind data; implementing a bounding heuristic, said bounding heuristic comparing said calculated energy yield for said given layout of turbines to a current lower bound, and if said calculated energy yield is greater than the current lower bound, replacing the current lower bound with the calculated energy yield; and repeating the above steps for different layouts of turbines on the grid. | 08-25-2011 |
20140156190 | METHODS, SYSTEMS AND COMPUTER PROGRAM STORAGE DEVICES FOR GENERATING A RESPONSE TO FLOODING - The present disclosure relates generally to methods, systems and computer program storage devices for generating a response to flooding. In one specific example, the present disclosure relates to methods, systems and computer program storage devices for generating one or more operational responses to flooding. | 06-05-2014 |
20140156232 | METHODS, SYSTEMS AND COMPUTER PROGRAM STORAGE DEVICES FOR GENERATING A FLOODING FORECAST - The present disclosure relates generally to methods, systems and computer program storage devices for generating a flooding forecast. In one specific example, the present disclosure relates generally to methods, systems and computer program storage devices for generating a flooding forecast for an urban environment. In another example, a fully conservative model may be utilized that allows employing an unstructured hybrid grid (1-dimesional/2-dimensional) to represent an urban area, where the 1-dimesional grid is a simplified representation of part of the domain. | 06-05-2014 |