Patent application number | Description | Published |
20080261257 | Fluorescent Proteins and Related Methods and Compounds - The invention includes fusion polypeptides including a first fluorescent protein, e.g., a FRET donor protein, a second fluorescent protein, e.g., a FRET acceptor protein, and, linked to at least one of the fluorescent (e.g., FRET donor or FRET acceptor) proteins, an Fc-region of an immunoglobulin. The polypeptide can be immobilized with respect to a surface via the Fc-region even in the absence of antibodies to either the FRET donor protein or FRET acceptor protein, and can be used as a calibration standard for fluorescence resonance energy transfer includes a polypeptide. | 10-23-2008 |
20090208501 | Anti-Pathogen Immunoadhesins - Chimeric molecules that include a pathogen recognition module derived from a pathogen binding domain of a pathogen recognition protein, e.g., a toll-like receptor (TLR), CD14, BPI, MD-2, scavenger receptors (SRs), surfactant proteins (SP), C-reactive protein (CRP), Mannan-binding lectin (MBL), or complement Clq globular binding domain, an optional linker, and an Fc portion of an antibody are described and are useful for, e.g., drug discovery and treatment of conditions related to TLR signaling. | 08-20-2009 |
20100291577 | Toll-Like Receptor 9 Modulators - TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described. | 11-18-2010 |
Patent application number | Description | Published |
20130233364 | SHADE SHELTER WITH SOLAR PANELS - A shade shelter includes one or more solar panels selectively mounted thereon. The shade shelter may be erected over an associated structure in order to at least reduce the thermal radiation effects of the sun on the associated shelter. | 09-12-2013 |
20130312799 | COLLAPSIBLE FRAME FOR A SHELTER - A frame is articulable between erected and a collapsed states and includes first and second frame supports. Each frame support has a pair of center frame members rotatably coupled about a center joint, each of which is selectively moveable between a first position when the frame is in the erected state and a second position when the frame is in the collapsed state. A purlin assembly has first and second purlin members that are rotatably coupled about a purlin mid-joint. A first end of the purlin assembly is pivotally coupled to the first frame support, and a second end of the purlin assembly is pivotally coupled to the second frame support. The purlin assembly is selectively lockable in an extended position when the frame is in the erected state and is rotatable to a folded position when the frame is in the collapsed state. | 11-28-2013 |
20150083177 | COLLAPSIBLE FRAME FOR A PORTABLE SHELTER - In a portable shelter frame, a frame support is selectively articulable between an erected state and a collapsed state. The frame support includes a central frame member; a pair of upper arcuate frame members rotatably coupled to the ends of the central frame member, each pair of frame upper frame members being selectively moveable between a first, fixed position when the frame support is in the erected state and a second, fixed position when the frame support is in the collapsed state; and a pair of lower arcuate frame members rotatably coupled to the other ends of the upper arcuate frame members, each pair of frame lower frame members being selectively moveable between a first, fixed position when the frame support is in the erected state and a second, fixed position when the frame support is in the collapsed state. A frame assembly may include two more of the frame supports, purlin assemblies interconnecting the frame supports, respectively, each purlin assembly including first and second purlin members rotatably coupled about a purlin mid-joint, a first end of the purlin assembly being pivotally coupled to one of the frame supports, and a second end of the purlin assembly being pivotally coupled to another frame support, the purlin assembly being selectively lockable in an extended position when the frame is in the erected state, the purlin members being rotatable to a folded position when the frame is in the collapsed state. | 03-26-2015 |
Patent application number | Description | Published |
20090282773 | Manufacture of Lattice Truss Structures from Monolithic Materials - Methods and systems to manufacture lattice-based sandwich structures from monolithic material. Such methods and systems eliminate the bonding process which is conventionally used to join lattice based truss cores to facesheets to form sandwich structures. This bonded interface is a key mode of failure for sandwich structures which are subjected to shear or bending loads because the nodes transfer forces from the face sheets to the core members while the topology for a given core relative density dictates the load carrying capacity (assuming adequate node-bond strength exists). An aspect comprises a core and related structures that provide very low density, good crush resistance and high in-plane shear resistance. An aspect of the truss structures may include sandwich panel cores and lattice truss topology that may be designed to efficiently support panel bending loads while maintaining an open topology that facilitates multifunctional applications. | 11-19-2009 |
20100236759 | Heat-Managing Composite Structures - Light-weight, heat-managing structures feature open-cell lattice, honeycomb, and/or corrugated (prismatic) arrangements in their substructures, combined with heat pipe/heat plate arrangements for managing heat to which the structures are subjected. The structures are well suited to aerospace applications and may be employed in the leading edge of wings or other airfoil-shaped components; gas turbine engine components; rocket nozzles; and other high-heat, high-stress environments. | 09-23-2010 |
20110042512 | Method and Apparatus for Jet Blast Deflection - Methods and apparatuses for passive jet blast deflection or the like. Use of the passive jet blast deflector permits the efficient dispersal of a fast moving local heat source into the environment through passive means while providing a high strength structure. The jet blast deflector system may include a first plate, a second plate, and a cellular core disposed between them adapted to allow cooling ambient air to flow through the cellular core, wherein the first plate, second plate, and core are all seamlessly coupled heat pipes that form a single vapor core to facilitate the spreading and even storing of thermal energy. An ejector plate may be attached to the top of the second plate to create a low pressure zone as the heat source passes over it, thereby pulling the ambient air through the cellular core, facilitating the removal the thermal energy from the system. | 02-24-2011 |
20110107904 | Synergistically-Layered Armor Systems and Methods for Producing Layers Thereof - The armor system according to the present invention also exploits synergistic multi-layering to provide different properties as a function of depth within a sandwich panel. Various embodiments of the invention include a combination of composite sandwich topology concepts with hard, strong materials to provide structures that (i) efficiently support static and fatigue loads, (ii) mitigate the blast pressure transmitted to a system that they protect, (iii) provides very effective resistance to projectile penetration, and (iv) minimizes shock (stress wave) propagation within the multi-layered armor sandwich structure. By using small pieces of highly constrained ceramic, the concept has significant multi-hit potential. | 05-12-2011 |
20120285114 | Manufacture of Lattice Truss Structures from Monolithic Materials - Methods and systems to manufacture lattice-based sandwich structures from monolithic material eliminate the bonding process which is conventionally used to join lattice-based truss cores to facesheets to form sandwich structures. The bonded interface is a key mode of failure for sandwich structures which are subjected to shear or bending loads because the nodes transfer forces from the facesheets to the core members while the topology for a given core relative density dictates the load carrying capacity (assuming adequate node-bond strength exists). In one aspect, a core and related structures provide very low density, good crush resistance and high in-plane shear resistance. Another aspect of the truss structures may include sandwich panel cores and lattice truss topology that may be designed to efficiently support panel bending loads while maintaining an open topology that facilitates multifunctional applications. | 11-15-2012 |