Patent application number | Description | Published |
20110208105 | METHOD FOR DETECTING THE ION CONCENTRATIONS OF CITRATE ANTI-COAGULATED EXTRACORPOREAL BLOOD PURIFICATION - The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit ( | 08-25-2011 |
20120125857 | SORBENT FOR REMOVING PROTEIN-BOUND SUBSTANCES - The invention relates to a sorption agent having improved selectivity properties for removing protein-bound substances from a biological fluid, in particular blood or blood plasma of patients having severe disturbances of the liver function or liver failure and having kidney insufficiency, the sorption agent having: (a) a porous, neutral, hydrophobic polymer and (b) a polypeptide layer adsorbed on the polymer, the neutral, hydrophobic polymer having a mean pore size of at least 15 nm. Furthermore, the invention relates to methods and uses in connection with such a sorption agent. The invention is used in particular in extracorporeal liver support. | 05-24-2012 |
20120152847 | SORBENT FOR ENDOTOXINS - The invention relates to a sorption agent for removing endotoxins from a biological fluid, the sorption agent having a water-insoluble, porous carrier and polymyxin, which is immobilized on the carrier, the carrier having a neutral, hydrophobic surface and polymyxin being immobilized on the surface of the carrier via hydrophobic interaction. The sorption agent is used in extracorporeal blood purification, in particular for treating individuals with sepsis. | 06-21-2012 |
20130105396 | NOVEL SORBENT FOR ENDOTOXINS | 05-02-2013 |
20150122712 | SAFETY APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT - Blood purification device ( | 05-07-2015 |
20150157779 | EXTRACORPOREAL PERFUSION APPARATUS - Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof. | 06-11-2015 |
20150190461 | DOSING INSTRUCTIONS FOR ENDOTOXIN-BINDING LIPOPEPTIDES - The invention relates to an endotoxin-binding lipopeptide selected from the group consisting of polymyxins, polymyxin derivatives, polymyxin analogues, prodrugs thereof and pharmaceutically acceptable salts thereof, and also relates to a preparation for parenteral administration comprising a lipopeptide of this type, for prophylaxis or for treatment of diseases and conditions caused by endotoxemia, by i) parenterally administering a bolus of the lipopeptide to achieve a lipopeptide serum concentration of 0.01 μg/ml to 0.8 μg/ml and ii) maintaining this lipopeptide serum concentration by parenterally administering the lipopeptide over a specifiable period of time. | 07-09-2015 |
20150328387 | EXTRACORPOREAL PERFUSION APPARATUS - Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof. | 11-19-2015 |