Patent application number | Description | Published |
20090270231 | FOOT EXERCISER AND ASSOCIATED METHODS - A foot, toe, and ankle exercise device provides variable resistance to movements in multiple directions. The device comprises a flexible forefoot support to allow for full toe and foot range of motion. The forefoot support includes a raised surface under the toes used to help align anatomical landmarks to delineate the resistance for the toes from that of the foot/ankle. Resistance may be provided by elastic banding or tubing that is mounted on an octagonal frame. Tensioners are provided to adjust the magnitude of the resistance. A height adjustable heel cup is mounted on a horizontal track to adjust the apparatus for use by different users with different size feet. A vertical track is provided to raise or lower the forefoot support and system of elastic banding or tubing so that full range movements are possible. In another version of the invention, inelastic banding along with weights is used to provide resistance. | 10-29-2009 |
20100261583 | PORTABLE FOOT AND ANKLE EXERCISE APPARATUS AND ASSOCIATED METHODS - A foot, toe, and ankle exercise device provides variable resistance to movements of the foot, ankle and toes in multiple directions. Embodiments of the device comprise a flexible forefoot support to allow for full toe and foot range of motion. Resistance is provided by resistance members that may comprise elastic banding or tubing. The forefoot support may be suspended by the resistance members. | 10-14-2010 |
20100298830 | APPARATUS AND METHODS FOR INTRODUCING PORTALS IN BONE - Some introducer tools for bone portals have a handle coupled to a driving member by a force-limiting coupling. A bone portal comprising a bone-penetrating portion and a bone stop may be driven to a desired depth in bone when the force-limiting coupling allows application of force to the bone portal that is sufficient to drive the bone-penetrating portion of the portal into the bone but not sufficient to drive the bone stop significantly into the bone. Bone portals of various types are described herein. Various configurations for stylets suitable for use in introducing bone portals or otherwise penetrating bone and methods for inserting bone portals are also described herein. | 11-25-2010 |
20100298831 | APPARATUS FOR INTRODUCING PORTALS IN BONE HAVING MOVABLE BONE PROBE - Some introducer tools for bone portals have a handle coupled to a driving member by a force-limiting coupling. A bone portal comprising a bone-penetrating portion and a bone stop may be driven to a desired depth in bone when the force-limiting coupling allows application of force to the bone portal that is sufficient to drive the bone-penetrating portion of the portal into the bone but not sufficient to drive the bone stop significantly into the bone. Bone portals of various types are described herein. Various configurations for stylets suitable for use in introducing bone portals or otherwise penetrating bone and methods for inserting bone portals are also described herein. | 11-25-2010 |
20120059346 | VIAL HANDLING AND INJECTION SAFETY SYSTEMS AND CONNECTORS - Systems and devices are provided to facilitate safe handling and injection of medicaments contained in vials. A vial handling system has at least one vial gripping member to hold a vial, and a filler pin movable relative to the vial gripping member for piercing a membrane seal on the vial. At least one window is provided in the vial handling system to permit access to remove a cap on the vial, while preventing needle access to the membrane seal through the window. In some embodiments, the vial contents are removed through a male end connector portion of a unique connector pair. A female end connector portion has a female socket with an inner fluid tube in fluid communication with a body of a syringe, while the male end connector portion has an engaging end dimensioned to fit within the female socket and securely overlap the inner fluid tube. | 03-08-2012 |
20130030439 | APPARATUS FOR INTRODUCING BONE PORTALS - Some introducer tools for bone portals have a handle coupled to a driving member by a force-limiting coupling. A bone portal comprising a bone-penetrating portion and a bone stop may be driven to a desired depth in bone when the force-limiting coupling allows application of force to the bone portal that is sufficient to drive the bone-penetrating portion of the portal into the bone but not sufficient to drive the bone stop significantly into the bone. Bone portals of various types are described herein. Various configurations for stylets suitable for use in introducing bone portals or otherwise penetrating bone and methods for inserting bone portals are also described herein. | 01-31-2013 |
20130072938 | APPARATUS AND METHODS FOR INTRODUCING PORTALS IN BONE - An apparatus and method for introducing portals into bone is described herein. An example apparatus for introducing portals into bone includes a handle, a base, and a driving member. The driving member can be made to project past the base by operating the handle. The base is detachable from the handle. The apparatus also includes a guide coupled at a first end to the handle and at a second end to the base. The base is detachably coupled to the guide. A base coupling detachably coupling the base to the guide includes an actuating member movable between a coupled configuration wherein the base is coupled to the guide and an uncoupled configuration wherein the base is released from the guide. The actuating member is arranged so that motion of the handle toward the base moves the actuating member from the coupled configuration to the uncoupled configuration. | 03-21-2013 |
20130158484 | APPARATUS FOR INTRODUCING PORTALS IN BONE HAVING TRANSVERSELY MOVABLE BONE PROBE - An apparatus for introducing a bone portal into a bone is described herein. An example apparatus for introducing portals into bone includes a stylet and a handle. The stylet is configured to support an infusion tube assembly. The infusion tube assembly comprises a bone portal. The handle is drivingly coupled to the stylet by a release mechanism. The release mechanism comprises a bone probe that, in a first configuration, extends generally parallel to the stylet. The release mechanism is operative to uncouple the driving coupling between the handle and the stylet upon axial motion of the bone probe relative to the handle. The stylet and bone probe are movable apart from one another to a second configuration. | 06-20-2013 |
20140039400 | APPARATUS AND METHODS FOR INTRODUCING PORTALS IN BONE - An apparatus and method for introducing portals into bone is described herein. An example apparatus for introducing portals into bone includes a handle, a base, and a driving member. The driving member can be made to project past the base by operating the handle. The base is detachable from the handle. The apparatus also includes a guide coupled at a first end to the handle and at a second end to the base. The base is detachably coupled to the guide. A base coupling detachably coupling the base to the guide includes an actuating member movable between a coupled configuration wherein the base is coupled to the guide and an uncoupled configuration wherein the base is released from the guide. The actuating member is arranged so that motion of the handle toward the base moves the actuating member from the coupled configuration to the uncoupled configuration. | 02-06-2014 |
Patent application number | Description | Published |
20130277548 | Method Of Mass Spectrometry And A Mass Spectrometer - The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas. | 10-24-2013 |
20130317756 | Method Of Deadtime Correction In Mass Spectrometry - A method of improving the fidelity of m/z dependent measurements for a species of interest in an analyte in a mass spectrometer, which method comprises the steps of acquiring raw data produced in a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent measurements with associated uncertainties. | 11-28-2013 |
20140005970 | Method Of Deadtime Correction in Mass Spectrometry | 01-02-2014 |
20150076341 | Method Of Mass Spectrometry And A Mass Spectrometer - The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas. | 03-19-2015 |
20150090872 | Mass Spectrometer - A hardware module which operatively carries out a method of compressing mass spectral data, the method comprising: receiving a first signal output from an ion detector of a mass spectrometer; processing the first signal to a digital signal at an output being data frame types representative of the first signal output; temporarily storing the data frame types in a memory block and reading a data frame from the memory block and determining its data frame type and according to its data frame type compressing the data frame according to one or more compression algorithms to generate a compressed data output stream. | 04-02-2015 |
20150120212 | METHOD FOR THE INVESTIGATION OF DIFFERENCES IN ANALYTICAL DATA AND AN APPARATUS ADAPTED TO PERFORM SUCH A METHOD - A method of investigating differences in data produced by at least one analytical instrument comprising providing a first data set from a first sample in a plurality of data bins; providing a second data set from a second sample in a plurality of data bins; providing a data model of said data sets in which the data in a plurality of data bins from the first data set is linked to the data in the corresponding bins of the second data set, each linked pair having an associated switch parameter linking the two together; and, exploring the posterior probability distribution for the data model as a function of the switch parameters to produce a posterior probability distribution map. | 04-30-2015 |
Patent application number | Description | Published |
20090099106 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION - Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. | 04-16-2009 |
20090285772 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION - Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. | 11-19-2009 |
20100129320 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION - Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. | 05-27-2010 |
20110256092 | QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION - Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. | 10-20-2011 |