Patent application number | Description | Published |
20140161688 | APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL - This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a test tube. The collector funnels the target material from the suspension through a cannula and into the processing vessel. The collector includes a funnel at a second end in fluid communication with the cannula. The cannula extends into a chamber at a first end of the collector that holds the processing vessel. In one implementation, the processing vessel is empty. In another implementation, the processing vessel includes at least one displacement fluid. In yet another implementation, the processing vessel may include at least one displacement fluid and at least one processing solution. The collector may also expel at least one displacement fluid from the processing vessel, such that the at least one displacement fluid pushes the target material into the collector. | 06-12-2014 |
20140219888 | TUBE AND FLOAT SYSTEM AND METHODS OF USING THE SAME - This disclosure is directed to systems and methods for analyzing target materials of a suspension include a tube and a float. The float may include expandable portions. The system traps a target analyte between the expandable float and the tube and/or to create a seal between the expandable float and the tube to inhibit fluid from flowing past the expandable float in the tube. The expandable portions may radially expand when exposed to an expanding fluid, such that the expanding fluid is not a naturally-occurring constituent of the suspension; or, the expandable portions may radially expand when a force is exerted upon the expandable portion. A tube may include expandable portions that expand towards the float. | 08-07-2014 |
20140287486 | DEVICE FOR ANALYSIS OF A TARGET ANALYTE - This disclosure is directed to a slide for analyzing target analytes of a suspension. The slide can be used to collect and hold the target analyte for imaging or further processing. The slide comprises a well section, including wells into which the target analyte can be stored. The wells may be removable and sized to fit into a second apparatus, such as a PCR thermocycler, for additional processing. Alternatively, the wells may hold processing vessels, such as PCR tubes, the processing vessels being used for downstream processing and/or analysis. | 09-25-2014 |
20140287487 | DEVICE, SYSTEMS AND METHODS FOR ANALYZING A TARGET ANALYTE - This disclosure is directed to a cap for obtaining a target analyte from a suspension. The cap introduces a magnetic field or a magnetic gradient to the tube to draw the target analyte bound to a particle to the cap. In one aspect, a cap includes a magnetic insert and a receiving piece. The magnetic insert includes a stopper and a magnet extending from the stopper; and, the receiving piece, which is configured to hold the magnetic insert, includes a receiving stopper and a sheath. The sheath may include imaging slides on opposite sides of the sheath. In another aspect, the cap may include a stopper and an embedded magnet. The cap may include an analysis piece on a bottom end of the stopper. In yet another aspect, the cap may include a fluid compartment and a filter at a bottom end of the stopper. | 09-25-2014 |
20140329300 | DEVICE FOR ANALYZING A SAMPLE AND METHOD OF USING THE SAME - This disclosure is directed to a device and method of using the device to analyze a sample. The sample may be a suspension, a portion of the suspension, a particular component of the suspension, or the like. For example, the suspension may be blood, the portion may be buffy coat, and the component may be circulating tumor cells. The device may be used to hold the sample for imaging or further processing. The device comprises a cavity that may be sealed on one side by a porous membrane and on an opposite side by a non-porous cover. The porous membrane allows for reagents to be introduced to the sample without diluting the sample. The non-porous cover allows for imaging of the sample. The device further comprises a nozzle for introducing the sample into a space within the cavity. | 11-06-2014 |
20140349828 | APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL - This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A fraction-density-altering solution may be added to a vessel that contains the sample to change the density of a first fraction of the sample without changing the density of the target material or the density of any other sample fraction. A collector may be inserted into the vessel to funnel the target material from the sample into the collector or into a processing receptacle included in the collector. In one implementation, the collector may include a cannula which extends into a chamber at a first end of the collector and a funnel at a second end that that is in fluid communication with the cannula. The chamber is sized and shaped to hold the processing receptacle. In another implementation, the processing receptacle may be inserted into a bore within the collector. | 11-27-2014 |
20150024427 | SOLUTION AND METHOD FOR ADHERING SUSPENSION COMPONENTS TO A SUBSTRATE - This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base and an anti-coagulant. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, such as acetone, or any combination thereof, such as Carnoy's solution. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured. The sample may be spread on the analysis platform after having been dispensed. The sample may then be fixed, permeabilized, labeled, blocked, and washed. The sample may then be imaged and analyzed. | 01-22-2015 |
20150056695 | APPARATUS FOR SPREADING A FLUID ACROSS A SUBSTRATE AND METHOD OF USING THE SAME - This disclosure is directed to an apparatus and method for spreading a fluid across a substrate. A spreader for spreading a fluid across a substrate includes a wiper and a frame. The wiper and the frame may mate to permit translation of the wiper across, and with respect to, the frame. The wiper spreads the fluid across the substrate and the frame supports the wiper and the substrate. The frame may also include a ramp to cause a portion of the wiper to lift away from the substrate. | 02-26-2015 |