Cutting
Brian Cutting, Basel CH
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20090239760 | Method for the Identification of New Leads for Drug Candidates - Disclosed is a method for producing new leads for drug candidates. The method employs a combinatorial approach for identifying high affinity ligands. The target may be unknown and/or may include one or more unknown binding sites. A method involving a combined screening and synthesis method for bi-site inhibitors is disclosed comprising: 1) determining if there is sufficient proximity between ligands binding to different sites of a target: e.g. by using spin-labelled ligands quenching can be measured with NMR if a first ligand and second allosteric ligand are in proximity 2) connecting both ligands having linkers, via in situ synthesis in the presence of the protein scaffold (e.g. target guided synthesis combined with fragment based self assembly). Click chemistry is a preferred embodiment here. Also disclosed are kits used in context of this method, leads discovered by the method and their use in drug development. Leads for drugs acting on myelin associated glycoprotein (MAG) have been identified and synthesised. | 09-24-2009 |
Gary A. Cutting, Dorset GB
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20130123501 | PROCESS FOR THE PREPARATION OF THE COMPOUND OSI-906 - Process for preparing the tyrosine kinase inhibitor OSI-906 comprises coupling Compound (2) with Compound (6) under specified conditions. | 05-16-2013 |
Jonathan Cutting, Hannover DE
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20160047764 | MONITORING OF THE FREEZING STATE OF A BIOPHARMACEUTICAL FLUID FOUND IN A CONTAINER - A device for monitoring the freezing state of a biopharmaceutical fluid in a container intended to receive a biopharmaceutical fluid that must pass between the liquid state and the frozen state, includes a peripheral envelope ( | 02-18-2016 |
20160068293 | FACILITY AND METHOD FOR PRODUCING A CONTAINER LOADED WITH A BIOPHARMACEUTICAL FLUID - A facility ( | 03-10-2016 |
Simon Cutting, Surrey GB
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20090175911 | Bacterial Production of Carotenoids - The present invention is based on a | 07-09-2009 |
Simon Michael Cutting, Egham-Surrey GB
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20120237544 | BACTERIAL SPORE HAVING THERAPEUTIC AGENT ADSORBED ON ITS SURFACE - The present invention relates to a method of coating a spore with one or more therapeutic agents. The present invention also relates to a coated spore obtained by the method of the present invention and the use of the coated spore as a vaccine. | 09-20-2012 |
20150343049 | Vaccine - The invention relates to vaccines, and particularly to vaccines active against pathogenic bacteria including | 12-03-2015 |
Simon Michael Cutting, Egham GB
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20140141031 | PATHOGENIC BACTERIA - The invention provides novel surface coat proteins of | 05-22-2014 |