Patent application number | Description | Published |
20090305816 | MULTILAYER GOLF BALL - The present invention encompasses a golf ball having a diameter and being comprised of a core and a cover, wherein the core is further comprised of a fluid mass at the center of the ball, and a first, solid, non-wound mantle layer surrounding the fluid mass, wherein the first mantle layer comprises a copolymer or terpolymer of ethylene and an α,β-unsaturated carboxylic acid, the acid being neutralized at least 80% by a salt of an organic acid, a cation source, or a suitable base of the organic acid, and wherein the cover comprises polyurethane, polyurea, or a polyurea/polyurethane hybrid. Preferably, the rate of spin decay is at least 10% of an initial spin rate of the golf ball over the entire ball flight. | 12-10-2009 |
20130281232 | MULTILAYER GOLF BALL - A method of making a ball, comprising: forming an inner core having a diameter of about 0.5 inches or lower; forming a plurality of outer core parts from an elastomeric material, each outer core part having an inner surface, an outer surface and at least one non planar mating surface, wherein the inner surface is concentrically disposed within the outer surface and comprises a cavity for receiving the inner core, and wherein the at least one nonplanar mating surface extends radially between the inner surface and the outer surface and comprises a plurality of mating ridges which extend from the inner surface to the outer surface; forming an outer core by mating the outer core parts about the inner core and joining the nonplanar mating surfaces by meshing the mating ridges to form a multi-layer core having a nonplanar parting line which extends about the outer surface circumferentially and intersects with the mating ridges at the outer surface; and molding a cover about the inner core, wherein the elastomeric material has a cohesive strength and the parting line has a mated strength equal to or greater than the cohesive strength. | 10-24-2013 |
20140011608 | MULTILAYER GOLF BALL - A method of making a ball, comprising: forming an inner core having a diameter of about 0.5 inches or lower; forming a plurality of outer core parts from an elastomeric material, each outer core part having an inner surface, an outer surface and at least one non planar mating surface, wherein the inner surface is concentrically disposed within the outer surface and comprises a cavity for receiving the inner core, and wherein the at least one nonplanar mating surface extends radially between the inner surface and the outer surface and comprises a plurality of mating ridges which extend from the inner surface to the outer surface; forming an outer core by mating the outer core parts about the inner core and joining the nonplanar mating surfaces by meshing the mating ridges to form a multi-layer core having a nonplanar parting line which extends about the outer surface circumferentially and intersects with the mating ridges at the outer surface; and molding a cover about the inner core, wherein the elastomeric material has a cohesive strength and the parting line has a mated strength equal to or greater than the cohesive strength. | 01-09-2014 |
Patent application number | Description | Published |
20100184724 | COMPOSITIONS FOR TREATING AND/OR PREVENTING DISEASES CHARACTERIZED BY THE PRESENCE OF METAL IONS - The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including organosilicon compounds. A composition of the invention may be administered to a mammal, such as a human. In some cases, the composition may include a silanol, a silandiol, a silantriol, or a cyclic organosilane, and/or be able to form a silanol, a silandiol, or a silantriol upon exposure to physiological conditions such as are found in the blood, in the stomach and/or gastrointestinal tract, or in the brain or other organ. In certain cases, the organosilicon compound may be bound to a moiety able to be transported across the blood-brain barrier into the brain, for example, an amino acid, a peptide, a protein, a virus, etc. The organosilicon compound may also be labeled (e.g., fluorescently or radioactively) in certain instances. In some embodiments, the composition, or a portion thereof, may sequester aluminum, copper, iron or other ions, for example, by electrostatically binding to the ions. The composition may also include other functionalities such as amines, certain alkyl and/or aryl moieties (including substituted alkyls and/or aryls), or hydrophobic moieties, for example, to facilitate transport of the organosilicon compound through the blood-brain barrier. | 07-22-2010 |
20110117603 | ENHANCEMENT OF CELLULAR PRODUCTION THROUGH MECHANOTRANSDUCTION - Disclosed herein are methods of modulating protein production via the application of tensegrity forces on cells and cell cultures. The methods of the invention increase production of protein from cells and cell culture. The tensegrity forces can be stress that is applied to the cells, and can include one or more of the following: mechanical stress, shear stress, stretch effects, and pressure induced stress. | 05-19-2011 |
20110236878 | Rapid Characterization of Proteins in Complex Biological Fluids - Disclosed herein are compositions and methods for the rapid screening of candidate protein therapeutics. In particular, the instant invention provides compositions and methods for assaying the behavior of candidate protein therapeutics in complex biological fluids and for identifying those candidate protein therapeutics exhibiting desirable pharmacokinetic properties in such fluids. | 09-29-2011 |
20110236906 | SECRETORY PROTEIN BIOMARKERS FOR HIGH EFFICIENCY PROTEIN EXPRESSION - The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells. | 09-29-2011 |
20140004531 | Secretory Protein Biomarkers For High Efficiency Protein Expression | 01-02-2014 |
20140271632 | METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING MONOSACCHARIDES AND OLIGOSACCHARIDES - The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells. | 09-18-2014 |
Patent application number | Description | Published |
20120195885 | COMPOSITIONS CONTAINING GLYCOSYLATED ANTIBODIES AND USES THEREOF - The present invention provides compositions of antibodies, e.g., human antibodies, of varying glycosylation structures that serve to achieve desired rates of serum clearance. The invention also provides methods for modulating the pharmacokinetics of antibodies, e.g., human antibodies, and therapeutic compositions containing such antibodies. These methods rely on varying the glycosylation structures of the antibodies, e.g., human antibodies, to achieve desired rates of serum clearance. | 08-02-2012 |
20150071944 | STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME - The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation. | 03-12-2015 |
Patent application number | Description | Published |
20140155896 | Instrument and Method to Enhance Articular Cartilage Regeneration - A perforation instrument and method of using same, including a shaft capable of being inserted into a joint of a patient, having a longitudinal axis, and carrying at least one piercing member, each piercing member having a tip suitable to pierce sub-chondral bone. The instrument is capable of being altered between an exposed condition wherein the tip of the at least one piercing member is exposed and a safety condition wherein the tip of the at least one piercing member is not capable of piercing tissue. | 06-05-2014 |
20140214039 | METHODS AND DEVICES FOR FORMING HOLES IN BONE TO STIMULATE BONE GROWTH - Methods and devices are provided for forming holes in bone to stimulate bone growth. In one exemplary embodiment, a surgical instrument set can include a driver having a first mating element, and a bone pick have a second mating element configured to releasably mate with the first mating element at any of a plurality of angular orientations. When releasably mated together, the driver and the bone pick can be configured to be adjustably positioned relative to one another with three degrees of freedom, e.g., pitch, yaw, and roll. The bone pick can include a piercing tip configured to form a hole in a bone, such as in microfracture. When the driver and the bone pick are releasably mated together, the driver can be configured to be struck, impacted, or otherwise manipulated to drive the piercing tip into the bone. | 07-31-2014 |
20140276884 | METHODS, SYSTEMS, AND DEVICES FOR GAUGING A BONE TUNNEL - Devices, systems, and methods are provided for gauging a bone tunnel. In one exemplary embodiment, a graft repair system can include an elongate pin, an elongate pusher shaft configured to be positioned over one opposed end of the pin when the pin is positioned within a bone tunnel, and a gauge member configured to be positioned over another opposed end of the pin when the pin is positioned within the bone tunnel. When the pusher shaft abuts the bone adjacent one of the open ends of the bone tunnel and the gauge member abuts the bone adjacent the other open end of the bone tunnel, an indicator mark on the pin can be visible through one or more windows formed in the gauge member. The indicator mark's position relative to each of the one or more windows can indicate one or more characteristics related to the bone tunnel. | 09-18-2014 |
20150272609 | Instrument and Method to Enhance Articular Cartilage Regeneration - A perforation instrument and method of using same, including a shaft capable of being inserted into a joint of a patient, having a longitudinal axis, and carrying at least one piercing member, each piercing member having a tip suitable to pierce sub-chondral bone. The instrument is capable of being altered between an exposed condition wherein the tip of the at least one piercing member is exposed and a safety condition wherein the tip of the at least one piercing member is not capable of piercing tissue. | 10-01-2015 |
Patent application number | Description | Published |
20090140463 | GOLF BALL MIXING AND DISPENSING PROCESS - The present invention provides an improved process for mixing castable polyurethanes and polyureas and for prolonging the dispensing time for dispensing them into a golf ball mold for application to a golf ball sub-assembly. A nozzle framework includes support housing heaters and heater adaptors for each dispensing port to delay the onset of drool and improve cut off in the dispensing tubes. The combination of fluorinated dispensing ports, the heating of the polyureas or polyurethanes, and inclusion of a capillary orifice in each dispensing port significantly prolongs the time before the advent of drool is detected. | 06-04-2009 |
20110081490 | METHODS OF CURING POLYUREA PREPOLYMERS FOR GOLF BALLS - Multi-piece, solid golf balls having a cover material made from a polyurea or polyurea/urethane hybrid composition are provided. In one version of the method, the cover materials are prepared by forming a polyurea prepolymer which undergoes two curing steps. In the first step, the prepolymer is partially-cured by reacting it with hydroxyl curing agents, amine curing agents, or mixtures thereof. In the second step, the composition is moisture-cured using environmental controls such as humidity chambers or hot water baths. In another version, a polyurea prepolymer is prepared and then treated with an aqueous curative blend comprising an amine curing agent. The cured materials may be used to make a golf ball cover having improved durability, cut/tear resistance, and impact strength. | 04-07-2011 |
20110081492 | METHODS OF CURING POLYURETHANE PREPOLYMERS FOR GOLF BALLS - Multi-piece, solid golf balls having a cover material made from a polyurethane/urea hybrid composition are provided. The balls include an inner core preferably made of polybutadiene and may include at least one intermediate layer disposed between the core and outer cover. The cover materials are prepared by first forming a polyurethane prepolymer which undergoes two curing steps. In the first step, the prepolymer is chemically-cured by reacting it with hydroxyl curing agents, amine curing agents, or mixtures thereof. In the second step, the composition is moisture-cured. The cured material may be used to make a golf ball cover having improved durability, cut/tear resistance, and impact strength. | 04-07-2011 |
20110081497 | METHODS OF CURING POLYUREA PREPOLYMERS FOR GOLF BALLS - Multi-piece, solid golf balls having a cover material made from a polyurea or polyurea/urethane hybrid composition are provided. The cover materials are prepared by first forming a polyurea prepolymer which undergoes two curing steps. In the first step, the prepolymer is chemically-cured by reacting it with hydroxyl curing agents, amine curing agents, or mixtures thereof. In the second step, the composition is moisture-cured. The cured material may be used to make a golf ball cover having improved durability, cut/tear resistance, and impact strength. | 04-07-2011 |
20110190075 | POLYUREA COVERS FOR GOLF BALLS BASED ON ISOCYANATE BLENDS - A golf ball having a cover material made from a polyurea or polyurea/urethane hybrid composition is provided. The polyurea or polyurea/urethane composition is produced by the reaction of an isocyanate blend having an average NCO functionality in the range of 2.05 to 2.35, a polyamine compound, and amine or hydroxyl curing agent. The resulting cover material has many advantages including improved thermal-stability, durability, toughness, and cut/tear-resistance. The preferred isocyanates in the blend include isophorone diisocyanate (“IPDI”); 1,6-hexamethylene diisocyanate (“HDI”); 4,4′-dicyclohexylmethane diisocyanate (“H | 08-04-2011 |
20120100935 | POLYURETHANE COVERS FOR GOLF BALLS BASED ON ISOCYANATE BLENDS - A golf ball having a cover material made from a polyurethane or polyurethane/urea hybrid composition is provided. The polyurethane or polyurethane/urea composition is produced by the reaction of an isocyanate blend having an average NCO functionality in the range of 2.05 to 2.35, a polyamine compound, and amine or hydroxyl chain-extender. The resulting cover material has many advantages including improved thermal-stability, durability, toughness, and cut/tear-resistance. The preferred isocyanates in the blend include isophorone diisocyanate (“IPDI”); 1,6-hexamethylene diisocyanate (“HDI”); 4,4′-dicyclohexylmethane diisocyanate (“H | 04-26-2012 |
20150343274 | MULTI-LAYERED GOLF BALLS MADE WITH A THIOL-ENE COMPOSITION - Methods for making multi-layered golf balls having at least one layer or coating made from a thiol-ene composition and the resultant golf balls are provided. A polymerizable composition comprising multifunctional thiol and -ene compounds is used to form the layer or coating. In one embodiment, the outer cover layer is made from the thiol-ene material. In another embodiment, a thiol-ene composition is applied as a protective coating over the outer cover layer. The thiol-ene layer or coating helps provide the ball with good impact durability and, toughness. | 12-03-2015 |