Patent application number | Description | Published |
20080318283 | Fermentation Process for Continuous Plasmid Dna Production - A continuous process is described for the production of microbial plasmid DNA for use in biopharmaceutical and biotechnological applications. The process consists of: first growing microbial cells containing a plasmid at a reduced temperature in a continuous stage; followed by a second plasmid induction continuous culture stage with an increased temperature, with a residence time that allows accumulation of the plasmid product. A hold step at a reduced temperature after fermentation further increases the yield of plasmid product. The method enables production of a large quantity of highly purified plasmid DNA from a small bioreactor over time. | 12-25-2008 |
20100184157 | E. COLI PLASMID DNA PRODUCTION - General methods and strains of bacteria are described, that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs. | 07-22-2010 |
20110281304 | PROCESS FOR PLASMID DNA FERMENTATION - Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature fed-batch fermentation strategies, combined with novel growth and induction phase temperature shifts. | 11-17-2011 |
20150203854 | E. COLI PLASMID DNA PRODUCTION - General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs. | 07-23-2015 |
20150225732 | E. COLI PLASMID DNA PRODUCTION - General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs. | 08-13-2015 |
Patent application number | Description | Published |
20160063496 | Remote Secure Transactions - Embodiments of the disclosure can provide systems, methods, and apparatus for remote secure transactions. In one embodiment, a payment processing system can be provided, which can include a network interface communicating with a memory, the memory communicating with a processor for executing payments, and the processor, when executing a computer program, performing operations. The operations can include storing, by the processor and to a memory associated with the payment processing system, account information associated with the consumer mobile system, and receiving, by the processor and from a consumer mobile device, a request, wherein the request comprises an account identifier associated with the consumer mobile device. The operations can also include validating, by the processor and from a consumer mobile device, the consumer mobile device based at least in part on the account identifier, and sending, by the processor, payment processing data, based on the validation. | 03-03-2016 |
Patent application number | Description | Published |
20120304255 | Systems and Methods for Authenticating Mobile Device Communications - Embodiments of the invention provide systems and methods for authenticating mobile device communications. A mobile device to which a message will be communicated may be identified. Based upon a shared secret between a service provider and the mobile device, a payload authentication code (“PAC”) may be generated, and the generated PAC may be associated with a payload for the message. The message and the generated PAC may then be communicated to the mobile device, and the mobile device may be configured to utilize the shared secret to verify the PAC and authenticate the message. In certain embodiments, the operations of the method may be performed by one or more computers associated with the service provider. | 11-29-2012 |
20120317019 | Card-Present On-Line Transactions - Embodiments of the invention can provide systems and methods for on-line credit card transactions. According to one example embodiment of the invention, a method can be provided. The method can include receiving, from a data manager, credit card information of a user; storing, on a secure element, the credit card information of the user; requesting a transaction with a merchant; receiving, from the merchant, a request for the credit card information; and sending, to the merchant, the credit card information of the user and a card-present indicator. | 12-13-2012 |
20150294362 | Systems and Methods for Managing Account Information - Systems and methods for managing account information can be provided by embodiments of the disclosure. In one embodiment, a consumer device may determine location information associated with the consumer device. The consumer device may determine, based at least in part on the location information, that the consumer device is located within a predetermined proximity to a merchant store location of a merchant. The consumer device may cause to send, a request to access the merchant device associated with the merchant. The consumer device may identify information associated with the merchant. The consumer device may determine, based at least in part on the account information, one or more consumer preferences associated with the merchant. The consumer device may access the merchant device based at least in part on the one or more consumer preferences. | 10-15-2015 |
Patent application number | Description | Published |
20140079774 | POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME - The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery. | 03-20-2014 |
20140301951 | POROUS NANOPARTICLE SUPPORTED LIPID NANOSTRUCTURES - Various exemplary embodiments provide protocell nanostructures and methods for constructing and using the protocell nanostructures. In one embodiment, the protocell nanostructures can include a core-shell structure including a porous particle core surrounded by a shell of lipid bilayer(s). The protocell can be internalized in a bioactive cell. Various cargo components, for example, drugs, can be loaded in and released from the porous particle core of the protocell(s) and then delivered within the bioactive cell. | 10-09-2014 |
20150272885 | POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY INCLUDING TRANSDERMAL DELIVERY OF CARGO AND METHODS THEREOF - The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery. | 10-01-2015 |
20160106671 | POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME - The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery. | 04-21-2016 |
Patent application number | Description | Published |
20090313857 | Shoe Housing - The invention relates to a shoe with a sole unit, where the sole unit includes a recess for removably receiving a housing of an electronic assembly, for example, an electronic pedometer, an accelerometer, or a speed sensor. Further, the invention relates to a housing for receiving an electronic assembly, for example, a pedometer, an accelerometer, or a speed sensor, where the housing has an outer shape corresponding to the shape of a recess formed in a shoe sole. | 12-24-2009 |
20110239488 | Shoe Housing - The invention relates to a shoe with a sole unit, where the sole unit includes a recess for removably receiving a housing of an electronic assembly, for example, an electronic pedometer, an accelerometer, or a speed sensor. Further, the invention relates to a housing for receiving an electronic assembly, for example, a pedometer, an accelerometer, or a speed sensor, where the housing has an outer shape corresponding to the shape of a recess formed in a shoe sole. | 10-06-2011 |
20130247423 | SHOE HOUSING - The invention relates to a shoe with a sole unit, where the sole unit includes a recess for removably receiving a housing of an electronic assembly, for example, an electronic pedometer, an accelerometer, or a speed sensor. Further, the invention relates to a housing for receiving an electronic assembly, for example, a pedometer, an accelerometer, or a speed sensor, where the housing has an outer shape corresponding to the shape of a recess formed in a shoe sole. | 09-26-2013 |
Patent application number | Description | Published |
20110270971 | SYSTEMS FOR AND METHODS OF USER DEMOGRAPHIC REPORTING USABLE FOR IDENTIFYING USERS AND COLLECTING USAGE DATA - Several ways of identifying users and collecting demographic information and market information are disclosed, including branding a browser with a unique identification in each user request, identifying a user by his key strokes or mouse clicks, gathering demographic information using multiple data sets and by monitoring network traffic. Additionally, user requested content is distinguished from other, non-user content, and the performance of a server can be monitor and analyzed from a client a client perspective. Further, an Internet user's Internet data is routed to a known domain on the Internet, from which it is routed on to the intended recipient. The domain includes proxy servers which proxy the user's data requests to the domain, and database servers, which filter and build a database of the user's Internet usage. Particular data concerning certain behaviors of interest, such as purchasing data, is filtered into the database, and can form the basis for numerous market measures. | 11-03-2011 |
20140280923 | SYSTEMS FOR AND METHODS OF USER DEMOGRAPHIC REPORTING USABLE FOR IDENTIFYING USERS AND COLLECTING USAGE DATA - Several ways of identifying users and collecting demographic information and market information are disclosed, including branding a browser with a unique identification in each user request, identifying a user by his key strokes or mouse clicks, gathering demographic information using multiple data sets and by monitoring network traffic. Additionally, user requested content is distinguished from other, non-user content, and the performance of a server can be monitor and analyzed from a client a client perspective. Further, an Internet user's Internet data is routed to a known domain on the Internet, from which it is routed on to the intended recipient. The domain includes proxy servers which proxy the user's data requests to the domain, and database servers, which filter and build a database of the user's Internet usage. Particular data concerning certain behaviors of interest, such as purchasing data, is filtered into the database, and can form the basis for numerous market measures. | 09-18-2014 |
Patent application number | Description | Published |
20120279362 | Powered Bolt-Through Tourque Wrench - A torque wrench assembly includes a housing having a motor assembly and a socket defining an opening extending along a longitudinal axis from a first end to a second end and having at least one fastener driving portion disposed at one of the first end and the second end of the socket. The torque wrench assembly includes a socket drive interface coupled to the housing and disposed in operative communication with the motor assembly and with the socket. | 11-08-2012 |
20120279365 | Bolt-Through Torque Wrench Assembly - A torque wrench assembly includes a handle, a socket housing coupled to the housing, and a socket rotatably coupled to the socket housing. The socket defines an opening extending along a longitudinal axis from a first end to a second end and having a fastener driving portion disposed at one of the first end and the second end of the socket. | 11-08-2012 |
20130283983 | Ratchet Wrench - A ratchet wrench is configured as a double-ended and reversible bolt-through wrench configured to actuate four different fastener sizes. The wrench can include socket hubs that can be provided in high-visibility colors to provide easy identification by the user. The socket hubs can include extension portions which extend beyond the respective faces of the handle to provide adequate contact between the socket hubs and a target fastener. Each socket hub includes a corresponding rotational direction controller or shifter that allows the socket hub to reverse it direction of rotational actuation relative to a fastener. | 10-31-2013 |
20140096654 | Impact Socket - An impact socket includes a socket body having a first end configured to mount to a drive shaft of an impact wrench and an opposing second end, the socket body defining at least one socket body fastener driving structure at the second end. The impact socket includes a collar assembly carried by the socket body, the collar assembly defining at least one collar assembly fastener driving structure. The collar assembly is configured to move linearly between (i) a first position relative to the socket body where a distal end of the collar assembly extends beyond a distal end of the socket body and (ii) a second position where the distal end is disposed at least equidistant to the second end of the socket body. | 04-10-2014 |
Patent application number | Description | Published |
20140002265 | System, Method, And Software For Automating Complex Alerts | 01-02-2014 |
20140022256 | TIME ALIGNMENT DISPLAY TECHNIQUE FOR A MEDICAL DEVICE - A system is presented including at least one sensor and a monitor in operable communication with the at least one sensor. The monitor is configured to display a plurality of graphs each representing a measured physiologic parameter versus time, the plurality of graphs configured to be aligned with respect to each other along a time axis. A marker moves along the time axis of each of the plurality of graphs in response to an input received from an input unit. The plurality of graphs are stacked with respect to each other in a vertical orientation and in a non-overlapping manner. | 01-23-2014 |
20140044201 | SYSTEM, METHOD, AND SOFTWARE FOR COMMUNICATING WITH MEDICAL DEVICES - A method for communicating with medical devices includes receiving, at a medical device communication interface, patient parameters from a first and second medical device in a respective first and second format. The method further includes identifying, at the medical device communication interface, a first and second protocol associated with the patient parameters by comparing the patient parameters and the first and second format to a predefined schema. The method further includes modifying, at the medical device communication interface, a respective configuration parameter for each of the first and second medical devices. The method further includes translating the patient parameters based on the first and second identified protocols and the respective configuration parameter for each of the first and second medical devices. | 02-13-2014 |
20140065952 | SYSTEM, METHOD, AND SOFTWARE FOR CONFIGURING COMMUNICATION WITH MEDICAL DEVICES - A method for configuring communication with medical devices includes a receiving, at a configuration interface, a first input indicative of first configuration parameters for a first medical device from a user and a second input indicative of second configuration parameters for a second medical device from the user. The first configuration parameters include at least one of a frequency parameter, a selection parameter, a compression parameter, an output parameter, and a port parameter. The method further includes receiving, at the configuration interface, first patient parameters from the first medical device and second patient parameters from the second medical device. The method further includes transmitting a first selected subset of the first patient parameters based on the first configuration parameters and transmitting a second selected subset of the second patient parameters based on the second configuration parameters. | 03-06-2014 |
20140085076 | SYSTEM, METHOD, AND SOFTWARE FOR CONTROLLING ALERT NOTIFICATIONS - A method for controlling alert notifications includes receiving, at an alert notification monitor, notifications from at least one medical device. The method further includes analyzing, at the alert notification monitor, the notifications based on one or more complex triggers to identify at least one triggered notification. The method further includes transmitting the at least one triggered notification. | 03-27-2014 |
20140085078 | SYSTEM, METHOD, AND SOFTWARE FOR AUTOMATING PHYSIOLOGIC DISPLAYS AND ALERTS WITH PRECEDENCE ORDER - A method for automating physiologic alerts with precedence order includes receiving at a mobile patient monitor interface, a first input expression indicative of a first parameter source for first patient parameters from a first medical device from a user. The method further includes receiving, at the mobile patient monitor interface, a second input expression indicative of a second parameter source for second patient parameters from a second medical device from a user. The method further includes modifying, at the mobile patient monitor interface, a precedence order of the first parameter source and the second parameter source. The method further includes evaluating, at the mobile patient monitor interface, a complex expression of the first patient parameters and the second patient parameters based on the precedence order to initiate display of at least one parameter, derived parameter, trend, or alert on a remote device. | 03-27-2014 |
20140085079 | SYSTEM, METHOD, AND SOFTWARE FOR AUTOMATING PHYSIOLOGIC ALERTS AND DERIVED CALCULATIONS WITH MANUAL VALUES - A method for automating physiologic alerts with manual values includes receiving at a mobile patient monitor interface, a first input expression indicative of a first parameter source for first patient parameters from a first medical device or input from a user. The method further includes receiving, at the mobile patient monitor interface, a second input expression indicative of a second parameter source for second patient parameters from a second medical device or input from a user. The method further includes evaluating, at the mobile patient monitor interface, a manual input value in the first input expression or the second input expression. The method further includes evaluating, at the mobile patient monitor interface, a complex expression of the first patient parameters and the second patient parameters based on the manual input value to initiate display of at least one alert or derived parameter on a remote device. | 03-27-2014 |
20140085080 | SYSTEM, METHOD, AND SOFTWARE FOR AUTOMATING PHYSIOLOGIC DISPLAYS AND ALERTS WITH TRENDING HEURISTICS - A method for automating physiologic alerts and derived parameters with trending heuristics includes receiving at a mobile patient monitor interface, a first input expression indicative of a first parameter source for first patient parameters from a first medical device from a user. The method further includes receiving, at the mobile patient monitor interface, a second input expression indicative of a second parameter source for second patient parameters from a second medical device from a user. The method further includes applying, at the mobile patient monitor interface, a smoothing operator to the first input expression and the second input expression. The method further includes evaluating, at the mobile patient monitor interface, a complex expression of the first patient parameters and the second patient parameters based on the smoothing operator to initiate display of at least one parameter, derived parameter, trend, or alert on a remote device. | 03-27-2014 |
20140235975 | SYSTEM AND METHOD FOR ADJUSTING CONFIGURATION PARAMETER COLLECTION RATES RECEIVED FROM A PLURALITY OF MEDICAL DEVICES - A medical device communication system is presented including a plurality of medical devices and at least one data collection module for capturing a set of values at a first rate, the set of values corresponding to configuration parameters acquired from the plurality of medical devices. The medical device communication system also includes at least one medical device driver electrically communicating with the at least one data collection module and at least one remote device configured to receive and display the set of values corresponding to the configuration parameters acquired from the plurality of medical devices. When at least one acute event is detected by at least one of the plurality of medical devices, the at least one data collection module captures the set of values of the configuration parameters at a second rate for a predetermined time interval, the second rate being greater than the first rate. | 08-21-2014 |
20140266783 | SYSTEM AND METHOD FOR IDENTIFYING NEWLY CAPUTURED CONFIGURATION PARAMETERS OF A PLURALITY OF MEDICAL DEVICES - A medical device communication system is presented including a plurality of medical devices, a data collection module for receiving at least pre-defined configuration parameters from each of the plurality of medical devices, and a medical device driver communicating with the data collection module, the medical device driver automatically capturing post-defined configuration parameters from the plurality of medical devices. The medical device communication system includes at least one remote device configured to receive the pre-defined and post-defined configuration parameters from the data collection module. The post-defined configuration parameters are received after the medical device driver is initially written and after initial electrical communication is established between the medical device driver and the data collection module. The medical device driver is prevented from being re-written each time post-defined configuration parameters are transmitted from at least one of the plurality of medical devices to the data collection module. | 09-18-2014 |
20150282708 | SYSTEMS AND METHODS FOR A MEDICAL CONNECTOR ENABLING WIRELESS COMMUNICATIONS - The present embodiments relate to a patient monitoring system having a patient monitor and a wireless pre-amplifier in wireless communication with the patient monitor. The wireless pre-amplifier is configured to receive a signal related to a physiological parameter of a patient from one or more sensors applied to the patient. The wireless pre-amplifier also includes a wireless attachment configured to wirelessly transmit the signal related to the physiological parameter of the patient to the patient monitor over a wireless communications channel, and an indicator feature configured to provide a user perceptible indication related to the wireless communication channel. | 10-08-2015 |