Patent application number | Description | Published |
20130058533 | IMAGE RECONSTRUCTION BY POSITION AND MOTION TRACKING - A system, method, and apparatus provide the ability to reconstruct an image from an object. A hand-held image acquisition device is configured to acquire local image information from a physical object. A tracking system obtains displacement information for the hand-held acquisition device while the device is acquiring the local image information. An image reconstruction system computes the inverse of the displacement information and combines the inverse with the local image information to transform the local image information into a reconstructed local image information. A display device displays the reconstructed local image information. | 03-07-2013 |
20130068527 | SYSTEMS AND METHODS FOR GRAVITY-INDEPENDENT GRIPPING AND DRILLING - Systems and methods for gravity independent gripping and drilling are described. The gripping device can also comprise a drill or sampling devices for drilling and/or sampling in microgravity environments, or on vertical or inverted surfaces in environments where gravity is present. A robotic system can be connected with the gripping and drilling devices via an ankle interface adapted to distribute the forces realized from the robotic system. | 03-21-2013 |
20130068623 | TRANSLOCATION AND NUCLEOTIDE READING MECHANISMS FOR SEQUENCING NANODEVICES - By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore. | 03-21-2013 |
20130069665 | USING A FIELD EFFECT DEVICE FOR IDENTIFYING TRANSLOCATING CHARGE-TAGGED MOLECULES IN A NANOPORE SEQUENCING DEVICE - A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. In other implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is implemented in the form of a nano-channel in a semiconductor layer. | 03-21-2013 |
20130085398 | BRAIN-MACHINE INTERFACE BASED ON PHOTONIC NEURAL PROBE ARRAYS - Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue. In another version, the method includes detecting photons from a volume of a tissue using a three-dimensional array of optical detectors inserted into the tissue. A probe device for illuminating tissue and/or detecting photons emitted from tissue includes elongated microsized probes containing optical emitters and optical detectors in a three dimensional array. | 04-04-2013 |
20130097164 | SYSTEMS AND METHODS FOR DISTRIBUTED DATA ANNOTATION - Systems and methods for distributed data annotation in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a distributed data annotation server system includes a storage device configured to store source data, one or more annotators, annotation tasks and a processor, wherein a distributed data annotation application configures the processor to receive source data including one or more pieces of source data, select one or more annotators, create one or more annotation tasks for the selected annotators and source data, request one or more annotations for the source data using the annotation tasks, receive annotations, determine source data metadata for at least one piece of source data using the received annotations, generate annotator metadata for at least one annotator using the received annotations and the source data, and estimate the ground truth for the source data using the source data metadata and the annotator metadata. | 04-18-2013 |
20130115656 | ENGINEERED YEAST CELLS AND USES THEREOF - The present application provides engineered yeast cells and uses thereof. In specific embodiments, the yeast cells have a mutation in the GAL2 gene. In specific embodiments, the yeast cells can be used for producing a protein or compound of interest. | 05-09-2013 |
20130121359 | INTEGRATED BROADBAND QUANTUM CASCADE LASER - A broadband, integrated quantum cascade laser is disclosed, comprising ridge waveguide quantum cascade lasers formed by applying standard semiconductor process techniques to a monolithic structure of alternating layers of claddings and active region layers. The resulting ridge waveguide quantum cascade lasers may be individually controlled by independent voltage potentials, resulting in control of the overall spectrum of the integrated quantum cascade laser source. Other embodiments are described and claimed. | 05-16-2013 |
20130121633 | SYSTEMS AND METHODS FOR TUNING A CAVITY - The present disclosure describes an integrated opto-mechanical and electro-mechanical system. The opto-mechanical and electro-mechanical system can be made of photonic crystals configured to move based on electrical voltages and/or back action effects from electromagnetic waves, thus changing the resonance of the system. | 05-16-2013 |
20130128227 | SYSTEMS AND METHODS FOR NONINVASIVE ANALYSIS OF RETINAL HEALTH AND FUNCTION - A method for noninvasive analysis of a retina includes exposing the retina to one or more first sets of at least three illumination light signals. The at least three illumination light signals each have a different wavelength. The method also includes optically collecting a reflected light signal for each of the at least three illumination light signals of the one or more first sets. Each of the reflected light signals is a portion of the respective illumination light signal reflected by the retina. The method further includes detecting the reflected light signals of the one or more first sets as a function of intensity. The method still further includes determining a first opsin density using the detected intensity of each of the reflected light signals of the one or more first sets. | 05-23-2013 |
20130129628 | FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES - Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging. | 05-23-2013 |
20130130254 | OPTICAL RESONATOR DIAGNOSTIC DEVICE AND METHODS OF USE - An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times. | 05-23-2013 |
20130133711 | PLASMONIC NANOSTRUCTURES FOR CONVERSION OF OPTICAL POWER TO ELECTRICAL POWER - A plasmoelectric device for conversion of optical power to direct current (DC) electrical power includes a first plasmonic nanostructure having a first resonance value and a second plasmonic nanostructure having a second resonance value. The first and second plasmonic nanostructures are electrically coupled and the first plasmonic nanostructure is configured to receive irradiation at a first irradiation value and the second plasmonic nanostructure is configured to receive irradiation at a second irradiation value, to induce charge transfer between the first and second plasmonic nanostructures. | 05-30-2013 |
20130137135 | COMPOSITIONS AND METHODS FOR LEUKOCYTE DIFFERENTIAL COUNTING - The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a sample having one or more leukocyte types with a diagnostic composition, exciting the leukocyte population with a light source; and measuring emitted light from each of the one or more leukocyte types to classify the leukocyte population. | 05-30-2013 |
20130137958 | MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS - A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure. | 05-30-2013 |
20130139931 | Amorphous Platinum-Rich Alloys - According to embodiments of the present invention, an amorphous alloy includes at least Pt, P, Si and B as alloying elements, and has a Pt weight fraction of about 0.925 or greater. In some embodiments, the Pt weight fraction is about 0.950 or greater. | 06-06-2013 |
20130139964 | AMORPHOUS METALS AND COMPOSITES AS MIRRORS AND MIRROR ASSEMBLIES - A mirror or mirror assembly fabricated by molding, pressing, assembling, or depositing one or more bulk metal glass (BMG), bulk metal glass composite (BMGMC), or amorphous metal (AM) parts and where the optical surface and backing of the mirror can be fabricated without machining or polishing by utilizing the unique molding capabilities of this class of materials. | 06-06-2013 |
20130140270 | IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT - Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC. | 06-06-2013 |
20130144399 | 3-DIMENSIONAL PARYLENE SCAFFOLD CAGE - Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane. | 06-06-2013 |
20130146998 | SINGLE-BAND AND DUAL-BAND INFRARED DETECTORS - Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the detector structure consists of, sequentially, a top contact layer, a unipolar hole barrier layer, an absorber layer, a unipolar electron barrier, a second absorber, a second unipolar hole barrier, and a bottom contact layer. In addition, by substantially reducing the width of one of the absorber layers, a single-band infrared detector can also be formed. | 06-13-2013 |
20130149351 | POLYMER SCAFFOLDS AND THEIR USE IN THE TREATMENT OF VISION LOSS - The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for growing RPE cells. Additionally, the present invention provides for RGD peptide linked polymer scaffolds for supporting the growth of RPE cells. The present invention provides methods of culturing RPE cells using the scaffolds produced herein. The present invention also provides methods of treating vision loss through the administration of RPE cell attached RGD peptide linked polymer scaffolds produced herein. The present invention further provides kits for treating vision loss. | 06-13-2013 |
20130149714 | BIO-DIAGNOSTIC TESTING SYSTEM AND METHODS - An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein. | 06-13-2013 |
20130150960 | ACCOMMODATING INTRAOCULAR LENS - Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens. | 06-13-2013 |
20130158377 | Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface - The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc. | 06-20-2013 |
20130165762 | SYSTEM AND METHOD FOR SENSING INTRAOCULAR PRESSURE - Systems and methods of sensing intraocular pressure are described. In one embodiment, a miniaturized IOP monitoring system is provided using a nanophotonics-based implantable IOP sensor with remote optical readout that can be adapted for both patient and research use. A handheld detector optically excites the pressure-sensitive nanophotonic structure of the IOP-sensing implant placed in the anterior chamber and detects the reflected light, whose optical signature changes as a function of IOP. Optical detection eliminates the need for large, complex LC structures and simplifies sensor design. The use of nanophotonic components improves the sensor's resolution and sensitivity, increases optical readout distance, and reduces its size by a factor of 10-30 over previously reported implants. Its small size and convenient optical readout allows frequent and accurate self-tracking of IOP by patients in home settings. Embodiments can also be used to monitor colonies of animals to support glaucoma research and drug discovery. | 06-27-2013 |
20130167360 | MICROMACHINED NEURAL PROBES - A neural probe includes at least one shaft, at least one first electrode disposed on a first side of the at least one shaft, and at least one second electrode disposed on a second side of the at least one shaft. The at least one second electrode is separately addressable from the at least first electrode. | 07-04-2013 |
20130174495 | DEPLOYABLE STRUCTURAL UNITS AND SYSTEMS - Deployable units and systems made of deployable units are described. The units have a retractable brace transitioning from a retracted condition to a deployed condition through a gravity driven movement, a latching arrangement contacting the brace and keeping the brace in position when the brace is in the deployed condition, and a guiding arrangement to guide the movement of the brace. The systems comprise plural deployable units to be arranged in a building structure, each unit to be located in a respective bay per story space of the building structure. | 07-11-2013 |
20130178360 | NICKEL-BASED ELECTROCATALYTIC PHOTOELECTRODES - The disclosure provides methods and compositions comprising metal alloy powders. The disclosure also provides a photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or nickel-molybdenum coated on the material. | 07-11-2013 |
20130178722 | Sharp Tip Carbon Nanotube Microneedle Devices and Their Fabrication - Carbon nanotube needles and needle arrays are described in which the precursor pillars are etched by oxygen plasma treatment to provide tapered and/or sharp-tip needles. Processes, products by process, and devices incorporating the sharp-tip needles are further described. | 07-11-2013 |
20130178736 | Noninvasive Systems for Blood Pressure Measurement in Arteries - Hardware and software methodology are described for a non-invasive approach to blood pressure measurement in pulmonary artery and systemic arteries by using wall displacement and blood velocity that are measured using ultrasound, microwave techniques and/or other radiofrequency (RF) techniques. | 07-11-2013 |
20130183676 | FILTERLESS TIME-DOMAIN DETECTION OF ONE OR MORE FLUOROPHORES - A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed. | 07-18-2013 |
20130183712 | METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION - The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engine˜red mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes. | 07-18-2013 |
20130184573 | Intrinsic Frequency Hemodynamic Waveform Analysis - Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition. | 07-18-2013 |
20130185035 | Systems and Methods of Analysis of Granular Elements - Systems and methods are described for performing mechanical analysis of particulate systems by describing particle morphology of particles within the system using Non-Uniform Rational Basis Spline (NURBS). One embodiment includes generating a NURBS description for the particle morphology of a plurality of particles within a particulate system, determining contact points between at least two particles based on the NURBS description, determining a magnitude of the contact between the at least two particles based on the NURBS description, determining normal forces and associated moments based upon the contact points and the magnitude of the contact between the at least two particles, determining tangential forces and associated moments based upon the contact points and the magnitude of the contact between the at least two particles, and performing mechanical analysis of the particulate system based on the contact between the at least two particles and the resulting forces and associated moments. | 07-18-2013 |
20130187094 | GRANULAR CRYSTAL - Granular crystals with one or more chains of particles are described. A geometry of at least one particle is chosen to provide highly nonlinear pulses having selected characteristics. Contact interactions between the particles are non-Hertzian. | 07-25-2013 |
20130188194 | BROADBAND, COMMON-PATH, INTERFEROMETRIC WAVEFRONT SENSOR - Hybrid sensors comprising Shack-Hartmann Wavefront Sensor (S-HWFS) and Zernike Wavefront Sensor (Z-WFS) capabilities are presented. The hybrid sensor includes a Z-WFS optically arranged in-line with a S-HWFS such that the combined wavefront sensor operates across a wide dynamic range and noise conditions. The Z-WFS may include the ability to introduce a dynamic phase shift in both transmissive and reflective modes. | 07-25-2013 |
20130201058 | PROCESSING SATELLITE DATA FOR SLANT TOTAL ELECTRON CONTENT MEASUREMENTS - A method, system, and apparatus provide the ability to estimate ionospheric observables using space-borne observations. Space-borne global positioning system (GPS) data of ionospheric delay are obtained from a satellite. The space-borne GPS data are combined with ground-based GPS observations. The combination is utilized in a model to estimate a global three-dimensional (3D) electron density field. | 08-08-2013 |
20130279631 | Dynamic Polarization Modulation and Control - A method for sending a data from an electromagnetic radiator by polarization modulation of an electromagnetic wave includes radiating from the radiator first and second electromagnetic waves including first and second polarizations respectively, the first polarization being different than the second polarization. The first and second electromagnetic waves form a third electromagnetic wave having a third polarization different from the first or second polarization. The method includes modulating the third polarization responsive to the data by modulating one or more parts of the third electromagnetic wave. The data is sent in the third polarization. A system for sending a data includes an oscillator adapted to generate an oscillating signal, and a phase shifter coupled to the oscillator and adapted to generate a first phase-shifted oscillating signal having a first phase. The phase shifter is adapted to vary the phase difference across a predefined range in response to the data. | 10-24-2013 |
20140041727 | HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS - High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels. | 02-13-2014 |