Brady, MD
James P. Brady, Gaithersburg, MD US
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20160053283 | Methods and Compositions for Generating Stable Transfected Cells - Methods and compositions are provided involving high producing cell lines. Embodiments concern efficient methods for screening for such cell lines and for creating such cell lines. These cell lines can be used to create large amounts of protein. To quickly generate large quantity of recombinant proteins or vaccines for both pre-clinical study and clinical trials, almost all drug development will face the same challenging obstacle of rapidly generating a high stable producer. Developing and identifying a stable cell line is a critical part of biopharmaceutical development. | 02-25-2016 |
Joseph V. Brady, Baltimore, MD US
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20110189643 | Programmed classroom instruction - A computer-implemented method of overseeing and adjusting the instruction and evaluation of a student with respect to one or more topics of study within a classroom. The subject matter of an academic course is studied and broken down into a plurality of discretely defined behavioral performances designed to be readily and objectively recognized as being mastered or not by a student. One or more of the discretely defined behavioral performances are then selected, with the aid of a first computerized database system, as learning objectives for the week. At the end of the week, a student is subsequently evaluated on these objectives. Results of the evaluation are then transferred to a second computerized database system, which organizes the collected data into an interactive learning management report that can be configured by a reviewer in real time to display a variety of levels of detail. | 08-04-2011 |
Ken M. Brady, Owings Mills, MD US
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20100030054 | CEREBRAL VASCULAR REACTIVITY MONITORING - A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The correlation may be used to assess vascular reactivity. | 02-04-2010 |
Ken M. Brady, Baltimore, MD US
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20100010322 | METHOD AND SYSTEM FOR DETERMINING A CEREBROVASCULAR AUTOREGULATION STATE OF A PATIENT - A method of diagnosing cerebrovascular autoregulation in a patient includes measuring blood pressure of the patient, measuring, non-invasively, venous oxygen content of the patient's brain substantially simultaneously with the measuring blood pressure, correlating the blood pressure and the venous oxygen content measurements in a time domain, and determining a cerebrovascular autoregulation state of the patient based on the correlating the blood pressure and the venous oxygen content measurements. | 01-14-2010 |
Ken M. Brady, Ellicott City, MD US
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20100228104 | CEREBRAL VASCULAR REACTIVITY MONITORING - A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate a linear correlation between the arterial blood pressure data and the tissue hemoglobin data. The correlation may be used to assess vascular reactivity. | 09-09-2010 |
Martin Brady, Baltimore, MD US
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20080200804 | METHOD AND APPARATUS FOR INFUSING SUBSTANCES - A method for determining a backflow of a substance along a track of a delivery device includes: a) obtaining parameters that influence the flow of the fluid or substance; b) acquiring information about delivery data; and c) computing the backflow along the delivery device using the information in steps a) and b). | 08-21-2008 |
20090270712 | MARGIN DETERMINATION/TUMOR CELL MIGRATION - A method for identifying target regions in a tissue for local drug delivery, wherein functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and wherein the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery. | 10-29-2009 |
Martin Brady, Monkton, MD US
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20080292160 | METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER - A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; a) acquisition of patient-specific medical data; b) estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; c) acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and d) computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained in (b) and (c). According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by means of medical data acquisition (e.g. MRI, CT, x-ray, ultrasound, SPECT, PET) and observing and/or measuring the backflow length along the catheter track. | 11-27-2008 |
20120046538 | METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER - A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; acquisition of patient-specific medical data; estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained above. According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by medical data acquisition and observing and/or measuring the backflow length along the catheter track. | 02-23-2012 |
20140243783 | METHOD OF BACKFLOW REDUCTION DURING MATERIAL DELIVERY THROUGH A NEEDLE INTO TISSUE - Interstitial tissue structure is treated with a flowable liquid agent by: providing a delivery cannula having a proximal end and a distal end and an external surface with at least one expandable member located on the external surface of at least one catheter or needle. The delivery cannula is inserted into live tissue, creating a hole in the tissue surrounding the delivery cannula. Contact is made against an inner surface of the hole with contact pressure from the at least one expandable member, said contact pressure establishing a first level of stress in tissue surrounding the hole in the tissue. The expandable member is expanded to increase the contact pressure and provide a second level of stress in the tissue surrounding the hole in the tissue to a second level of stress that is greater than the first level of stress. | 08-28-2014 |
20140303593 | DELIVERY OF MATERIALS INTO MARGINS OF TISSUE CAVITIES - Surgery is performed on a patient with a novel device by: | 10-09-2014 |
Martin L. Brady, Monkton, MD US
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20090287141 | Device and method for delivering therapeutic agents to an area of the body - A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution. | 11-19-2009 |
20110106009 | DEVICE AND METHOD FOR DELIVERING THERAPEUTIC AGENTS TO AN AREA OF THE BODY - A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution. | 05-05-2011 |
Martin L. Brady, Phoenix, MD US
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20100030102 | Active Delivery and Flow Redirections: Novel Devices and Method of Delivery of Materials to Patients - A medical device and method for planning or performing a method for delivering material through tissue into a defined area of a patient may comprise: a material delivery element through which the material may flow out of a delivery end; and observing the migration, flow and persistence of material delivered and developing an plan or optimizing a plan for the delivery of material into the defined area. Novel catheter devices are provided to support these methods. | 02-04-2010 |
Rebecca A. Brady, Laurel, MD US
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20100285496 | Methods and Devices for the Detection of Biofilm - The present invention provides methods and kits for biofilm detection. | 11-11-2010 |
20110171123 | In Vivo Biofilm Infection Diagnosis and Treatment - The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections. | 07-14-2011 |