Blümel
Claudia Blümel, Munich DE
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20110262439 | BISPECIFIC SINGLE CHAIN ANTIBODIES WITH SPECIFICITY FOR HIGH MOLECULAR WEIGHT TARGET ANTIGENS - The present invention provides a method for the selection of bispecific single chain antibodies comprising a first binding domain capable of binding to an epitope of CD3 and a second binding domain capable of binding to the extracellular domain cell surface antigens with a high molecular weight extracellular domain. Moreover, the invention provides bispecific single chain antibodies produced by the use of the method of the invention, nucleic acid molecules encoding these antibodies, vectors comprising such nucleic acid molecules and methods for the production of the antibodies. Furthermore, the invention provides pharmaceutical compositions comprising bispecific single chain antibodies of the invention, medical uses of the same and methods for the treatment of diseases comprising the administration of bispecific single chain antibodies of the invention. | 10-27-2011 |
20120034228 | CROSS-SPECIES-SPECIFIC PSCAxCD3, CD19xCD3, C-METxCD3, ENDOSIALINxCD3, EPCAMxCD3, IGF-1RxCD3 OR FAPALPHAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY - The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an antigen selected from the group consisting of Prostate Stem Cell Antigen (PSCA), B-Lymphocyte antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), Endosialin, the EGF-like domain 1 of EpCAM, encoded by exon 2, Fibroblast activation protein alpha (FAP alpha) and Insulin-like growth factor I receptor (IGF-IR or IGF-1R). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule. | 02-09-2012 |
Klaus Blümel, Dinslaken DE
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20090280348 | Structured composite sheet - A composite sheet comprising two sheets joined by material closure provides on the one hand high global and local bending stiffness, and on the other hand very good forming behavior and very high load capacity in case of great deformations, as in case of a crash for example. Both sheets of the composite sheet comprise an at least partially structured surface and a smooth surface and both sheets are at least partially joined by material closure via the structured surfaces. | 11-12-2009 |
Klaus Blümel, Dinslaken DE
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20090280348 | Structured composite sheet - A composite sheet comprising two sheets joined by material closure provides on the one hand high global and local bending stiffness, and on the other hand very good forming behavior and very high load capacity in case of great deformations, as in case of a crash for example. Both sheets of the composite sheet comprise an at least partially structured surface and a smooth surface and both sheets are at least partially joined by material closure via the structured surfaces. | 11-12-2009 |
Michael Blümel, Flatz AT
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20100320782 | ENERGY ABSORPTION DEVICE - The present invention relates to an energy absorption device ( | 12-23-2010 |
20130119683 | Bumper Assembly - A method of making a beam-box crash management system comprises forming a first shell ( | 05-16-2013 |
Michael Blümel, Flatz AT
Patent application number | Description | Published |
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20080217128 | Energy Absorption Apparatus and Method for Producing an Integral Energy Absorption Apparatus - The present invention relates to an energy absorption apparatus having a first hollow longitudinal section ( | 09-11-2008 |
20100320782 | ENERGY ABSORPTION DEVICE - The present invention relates to an energy absorption device ( | 12-23-2010 |
20130119683 | Bumper Assembly - A method of making a beam-box crash management system comprises forming a first shell ( | 05-16-2013 |
20140292008 | Bumper Assembly - A method of making a beam-box crash management system comprises forming a first shell ( | 10-02-2014 |
20140367984 | Crash Box For A Bumper Assembly - A crash box includes a body portion extending from a top edge to a bottom edge along a global z-axis (A) and having a pair of side walls disposed in spaced relationship to one another. At least one x-shaped reinforcing web extends between the side walls along a plane (P) disposed transverse to the axis (A). An extension portion is integral with the body portion and extends outwardly from one of the side walls and is disposed along the plane (P). A flange plate is also integral with the body portion and defines at least one flange plate attachment hole for securing the crash box to a frame of a vehicle. | 12-18-2014 |
Siegfried Blümel, Ratigen DE
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20100282128 | Titanium dioxide pigment particles with doped, dense SiO2 skin and methods for their manufacture - A method of predicting photostability of coatings with various dopants on titanium dioxide pigment particles is disclosed. Calculations of the density of states show that a doped coating which reduces the density of states near the band edge or increases the density of states within the band gap of the pigment particles increases the photostability of the doped pigment. | 11-11-2010 |
Siegfried Blümel, Ratigen DE
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20100282128 | Titanium dioxide pigment particles with doped, dense SiO2 skin and methods for their manufacture - A method of predicting photostability of coatings with various dopants on titanium dioxide pigment particles is disclosed. Calculations of the density of states show that a doped coating which reduces the density of states near the band edge or increases the density of states within the band gap of the pigment particles increases the photostability of the doped pigment. | 11-11-2010 |
Simon Blümel US
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20110085336 | ILLUMINATION DEVICE - An illumination device is specified which comprises an optoelectronic component having a housing body and at least one semiconductor chip provided for generating radiation, and a separate optical element, which is provided for fixing at the optoelectronic component and has an optical axis, the optical element having a radiation exit area and the radiation exit area having a concavely curved partial region and a convexly curved partial region, which at least partly surrounds the concavely curved partial region at a distance from the optical axis, the optical axis running through the concavely curved partial region. | 04-14-2011 |
Simon Blümel US
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20110085336 | ILLUMINATION DEVICE - An illumination device is specified which comprises an optoelectronic component having a housing body and at least one semiconductor chip provided for generating radiation, and a separate optical element, which is provided for fixing at the optoelectronic component and has an optical axis, the optical element having a radiation exit area and the radiation exit area having a concavely curved partial region and a convexly curved partial region, which at least partly surrounds the concavely curved partial region at a distance from the optical axis, the optical axis running through the concavely curved partial region. | 04-14-2011 |
Simon Blümel, Schierling DE
Patent application number | Description | Published |
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20090213469 | Optical Element, Production Method Therefor, and Composite Component Provided With an Optical Element - An optical element ( | 08-27-2009 |
20090213575 | ILLUMINATION DEVICE - A lighting apparatus comprising a plurality of light modules is specified, wherein | 08-27-2009 |