Blanka
Blanka Gonczy, Cardiff GB
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20140057866 | PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER - Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase. | 02-27-2014 |
Blanka Kepska, Minsk Mazowiecki PL
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20120308666 | Method of Manufacturing the Silica Nanopowders with Biocidal Properties, Especially for Polymer Composites - Silica nanopowders with biocidal properties, especially for polymer composites, are produced by sol-gel method. The silica sol is produced from the aqueous mixture containing tetraalkoxysilane, in which alkoxy group contains from C | 12-06-2012 |
20130045282 | Method of Manufacturing the Silica Nanopowders With Fungicidal Properties, Especially for Polymer Composites - Method of manufacturing the silica nanopowders with fungicidal properties, consists in that the silica gel is obtained by sol-gel method from the reaction mixture containing tetraalkoxysilane and aliphatic alcohol, in the presence of ammonium compound, and thereafter the thermodegradable copper(II) salt a compound from the group of carbofunctional alkoxysilanes, and then, after evaporation of solvents the dry residue is heated at the decomposition temperature of copper(II) salt. | 02-21-2013 |
Blanka Lenczowski, Neubiberg DE
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20150053289 | Structural Component With a Riblet Surface - A structural component for a vehicle has a surface with a riblet structure. The riblet structure includes a plurality of grooves, including a first groove having a first longitudinal section forming a first angle with a main longitudinal direction of the structural component. The first angle is larger than 0° and the main longitudinal direction corresponds to a flow direction of a fluid along the surface of the structural component. | 02-26-2015 |
20150071324 | Structural Health Monitoring System for a Material and Production Method - A structural health monitoring system includes a signal transmission element and a sensor unit. The sensor unit is designed to feed a first signal into the signal transmission element and to read out a second signal from the signal transmission element. The signal transmission element has carbon nanotubes. | 03-12-2015 |
Blanka Rihova, Praha CZ
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20080318879 | Method for the Preparation of Polymeric Conjugates of Doxorubicin with Ph-Controlled Release of the Drug - A method for the preparation of polymeric conjugates of N-(2-hydroxypropyl)methacrylamide and a methacryloylaminoacylhydrazone of doxorubicin with pH-controlled release of the drug, comprising the following three steps of synthesis: a. preparation of a monomeric methacryloylaminoacylhydrazine, wherein the aminoacyl is derived from an amino acid or oligopeptide, by reaction of a methacryloyl halide with the respective peptide, amino acid, or a derivative thereof, and subsequent hydrazinolysis, b. synthesis of a polymeric precursor by direct copolymerization of N-(2-hydroxypropyl)methacrylamide with the methacryloylaminoacylhydrazine, and c. binding of doxorubicin to the polymeric precursor by reaction thereof with doxorubicin hydrochloride. | 12-25-2008 |
20090306004 | GRAFTED MACROMOLECULAR CONJUGATES OF DOXORUBICIN WITH ANTICANCER ACTIVITY AND METHOD OF THEIR PREPARATION - A polymeric drug, in which a cancerostatic connected via spacers containing hydrolytically cleavable hydrazone bonds is bound to a water-soluble polymeric carrier prepared on the basis of a N-(2-hydroxypropyl)methacrylamide copolymer, wherein the structure of the polymeric drug consists of the main chain of N-(2-hydroxypropyl)methacrylamide carrying the cancerostatic and another chain of N-(2-hydroxypropyl)methacrylamide—a graft, which may also carry a cancerostatic, said grafts being bound to the main chain by a bond that is stable in the body and/or by a bond cleavable in the body, especially by an oligopeptide spacer selected from the series of GlyLeuGly, GlyPheGly, GlyPheLeuGly and GlyLeuPheGly, and a method of its preparation. | 12-10-2009 |
20120296048 | Dendritic High-molecular-weight Polymer Drug Carriers and Their Conjugates with Drugs Especially for Treatment of Solid Tumours - The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors. | 11-22-2012 |
Blanka Toukoniitty, Porvoo FI
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20130090502 | PROCESS FOR MANUFACTURE OF LIQUID FUEL COMPONENST FROM RENEWABLE SOURCES - A method for producing liquid fuel components from renewable oil. A fresh feedstock including saturated fatty acids is subjected to dilution by an organic lipophilic solvent. The solvent has a low phosphorus and metal impurity content, less than 5 ppm and less than 10 ppm, respectively. Dilution is performed before and/or during purification by at least one pretreatment process for removal of phosphorus and metal impurities. Subsequently, the resulting purified feedstock is fed into at least one post-treatment process suitable for producing liquid fuel components. | 04-11-2013 |
Blanka Zelezna, Praha 6 CZ
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20150175674 | LIPIDATED PEPTIDES AS ANTI-OBESITY AGENTS - Lipidated peptides, analogs of both forms of the prolactin-releasing peptide, PrRP31 and PrRP20, represent anorexigenic compounds that lower food intake and function in the brain after peripheral administration. The analogs PrRP31 and PrRP20 lipidated at the N-terminus by myristic or palmitic acids bind with high affinity to the endogenous receptor GPR10 in the rat pituitary cell line RC-4B/C and CHO cell line with transfected human receptor. These lipidated peptides also significantly decrease, in a dose-dependent manner, the food intake in fasted mice and have similar effects in comparable doses as centrally administered natural PrRP31, these effects are, however, stronger and longer lasting. Lipidation of an effective anorexigenic neuropeptide PrRP induces a central effect after peripheral administration and thus makes the lipidated analogs of PrRP a promising anti-obesity drug. | 06-25-2015 |