Patent application number | Description | Published |
20090325919 | METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION - The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. | 12-31-2009 |
Patent application number | Description | Published |
20090208444 | Novel Formulation - A sanitising formulation comprising a solution of an acidic polymer and an anionic surfactant in a liquid vehicle. Suitable acidic polymers are those which include adjacent | 08-20-2009 |
20100018533 | Novel Device - A face mask comprising a filter material being a fibrous substrate, especially non-woven polypropylene or polyester, having an acidic polymer, especially of the Carbopol or Gantrez type, deposited on the fibres. The mask has an anti-viral activity against inhaled or exhaled air. A filter material suitable for such a mask, and a process for making it are also described. | 01-28-2010 |
20120087962 | NOVEL ARTICLE - Aspects of the present invention are directed to personal protection articles, such as protective clothing, articles for sequential contact with multiple users, and cellulosic articles, which have their surface a coating formulation having activity to de-activate pathogenic micro-organisms, the coating comprising an acidic polymer, suitably the polymaleic acid material Gantrez™, a surfactant and an acid. Processes for making such articles, and suitable coating formulations are also disclosed. | 04-12-2012 |
Patent application number | Description | Published |
20080237327 | Food Container With a Holder For a Condiment Cup - A food container in combination with a condiment container having a lip, a lower lip edge and a top edge. The food container includes at least one wall. A bottom connected to the wall defines a containment space. A slit formation is formed in the wall, the slit formation has a lower slit and an upper slit substantially parallel to the lower slit. The slits define a loop that is displaceable into the containment space for supporting the condiment container by urging the condiment container against the wall. The lower slit defines a wall lower ledge disposed for supporting the lower lip edge of the condiment container. | 10-02-2008 |
20110034957 | BONE ANCHORING DEVICE - A bone anchoring device includes a bone anchoring element having a shank and a head, a continuous one-piece receiver member, a continuous one-piece first locking element and a second locking element. The receiver member has a first chamber for receiving the head, the head being pivotable in the first chamber, and a second chamber with a channel for receiving the rod. A first locking element fixes the head in the first chamber at an angle, and a second locking element fixes the rod in the second chamber. The receiver member includes a body including both the first chamber and the second chamber. The head and the rod can be inserted and locked independently from each other. The head is fixed by exerting pressure onto it. The bone anchoring device is particularly applicable to the stabilization of the spine in the sacro-iliac and the cervical region. | 02-10-2011 |
20120059425 | Locking Element for a Polyaxial Bone Anchor, Bone Plate Assembly and Tool - A locking element is configured to be used with a polyaxial bone anchor, and is substantially cylindrical with a bottom side facing a head of the bone anchor, a top side opposite to the bottom side, and a surface portion with an external thread. The locking element has a first recess at the bottom side for accommodating at least a portion of the head, and a second recess at the top side for engagement with a driver. The second recess is located outside the center of the top side. The head has a portion with a largest diameter, and a first level L | 03-08-2012 |
20120089192 | Bone Plate Assembly with Guide Member - A bone plate assembly is provided including a plate member with a top side ( | 04-12-2012 |
20130110172 | LOCKING ASSEMBLY FOR A POLYAXIAL BONE ANCHORING DEVICE | 05-02-2013 |
20130110178 | HIGH ANGULATION POLYAXIAL BONE ANCHORING DEVICE | 05-02-2013 |
20140081269 | MODULAR BONE PLATE AND MEMBER OF SUCH A MODULAR BONE PLATE - A member of a modular bone plate is provided, the member comprising a top surface defining a top plane; a bottom surface defining a bottom plane; a connection portion including a hole with a center axis that intersects the top plane and the bottom plane; wherein a first portion of the edge of the hole is provided with a projection forming a first free end of the member and wherein a second portion of the edge of the hole is provided with a groove that is configured to accommodate a projection of a connection portion of a second member of the modular bone plate. Furthermore, a modular bone plate having at least two such members is provided. | 03-20-2014 |
20140100572 | MODULAR BONE PLATE AND CONNECTOR PIECE FOR A MODULAR BONE PLATE - A modular bone plate is provided including at least a first and a second member each having a top surface and a bottom surface, the first member comprising a male connection portion with a single hole extending from the top surface to the bottom surface and the second member comprising a female connection portion with a single hole extending from the top surface to the bottom surface, wherein the male connection portion is insertable into the female connection portion such that the holes overlap and wherein an anchor or a plug member is insertable into the holes when they overlap. | 04-10-2014 |
20140350607 | LOCKING ASSEMBLY FOR A POLYAXIAL BONE ANCHORING DEVICE - A locking assembly for securing a rod in a polyaxial bone anchoring device includes a first locking element having a first end, a second end, an outer surface with an external advancement structure, an inner wall, an internal advancement structure on the inner wall, and an engagement portion for a tool, and a second locking element having a first end configured to be oriented towards the first end of the first locking element, an opposite second end, an outer surface with an external advancement structure configured to cooperate with the internal advancement structure of the first locking element, and a portion at the second end having a width greater than a greatest width of the external advancement structure of the second locking element, wherein the second locking element is configured to move axially relative to the bone anchoring device at a speed different than the first locking element. | 11-27-2014 |
20150039033 | IMPLANT FOR BONES OR VERTEBRAE WITH SELF-CONSTRAINED FLEXIBILITY - As implant for the stabilization of bones or vertebrae is provided, the implant being a solid body including a longitudinal axis that defines a longitudinal direction and including a flexible section that has a surface and has a length in the longitudinal direction, the flexible section including at least one cavity located near the surface and having a width in the longitudinal direction that is smaller than the length of the flexible section, the at least one cavity being connected to the surface through at least one slit, and a width of the slit in the longitudinal direction being smaller than the width of the cavity. | 02-05-2015 |
20150134016 | BONE ANCHOR AND BONE ANCHORING ASSEMBLY COMPRISING THE SAME - A bone anchor includes: a main body defining a longitudinal axis and including a head; at least one insertion hole which extends from a first opening formed in the head to a second opening formed in the main body, the at least one insertion hole having an axis which is arranged to be inclined with respect to the longitudinal axis of the main body at an angle, and the insertion hole being configured to receive and guide therethrough a pin-shaped element to be anchored within a bone or bone fragment; and a locking device configured to lock the position of the pin-shaped element inserted within the at least one insertion hole in an axial direction. | 05-14-2015 |
20150320462 | BONE PLATE WITH ENLARGED ANGLE OF INCLINATION FOR A BONE ANCHOR TO A FAVORED SIDE - The invention relates to a bone plate assembly for use in orthopaedic or trauma surgery. The bone plate assembly includes a plate member having a top side and a bottom side at least one passage extending from the top side to the bottom side; wherein the at least one passage includes a first bore with a first end open towards the top side and a second end, a seat portion configured to receive the head of the bone anchor; and wherein the first bore comprises a first central axis and the seat portion comprises a second central axis, and wherein the first central axis and the second central axis intersect each other within the passage; and a second bore open towards the bottom side. | 11-12-2015 |
Patent application number | Description | Published |
20130085536 | BONE ANCHORING DEVICE AND TOOL COOPERATING WITH SUCH A BONE ANCHORING DEVICE - A bone anchoring device includes a receiving part including a rod receiving portion with a first end, a second end, and a U-shaped recess for receiving a rod, the recess defining two free legs, and a head receiving portion at the second end for introducing and clamping the head, and a locking ring configured to be arranged around the head receiving portion, the locking ring including an engagement structure for engagement with a tool, the engagement structure defining a width of the locking ring that is greater than a greatest width of the rod receiving portion, wherein the locking ring can assume a locking position exerting a greatest compressive force on the head receiving portion of the receiving part to lock an inserted head, and wherein the locking ring is movable out of the locking position towards the first end of the rod receiving portion. | 04-04-2013 |
20130096622 | POLYAXIAL BONE ANCHORING DEVICE - A polyaxial bone anchoring device includes an anchoring element having a shaft and a head, a receiving part having a first end and a second end, a bore extending from the first end towards the second end, a seat for receiving the head, and at least one threaded through hole transverse to the bore, a pressure element to exert pressure onto the head, such that the head is pivotable and can be locked at an angle relative to the receiving part, the pressure element having at least one hole configured to at least partially align with the through hole, and at least one set screw threadable into the through hole to engage the pressure element at the hole such that a force is exerted by the pressure element onto the head that maintains the head at an adjustable angular position relative to the receiving part by friction. | 04-18-2013 |
20130096623 | POLYAXIAL BONE ANCHORING DEVICE WITH ENLARGED PIVOT ANGLE - A polyaxial bone anchoring device includes a bone anchoring element having a shank and a head, a receiving part including a rod receiving portion, and a head receiving portion having a first end and an open second end with a bounding edge, wherein the head receiving portion is configured to be rotatably connected to the rod receiving portion and is flexible for introduction and clamping of the head, and a locking ring configured to be mounted around the head receiving portion, wherein the head is insertable into the head receiving portion from the second end, is pivotable in the head receiving portion at a larger maximum pivot angle relative to the receiving part at a first location of the bounding edge, and can be locked at an angle relative to the receiving part by compressing the head receiving portion with the locking ring. | 04-18-2013 |
20130338716 | POLYAXIAL BONE ANCHORING DEVICE - A polyaxial bone anchoring device is provided comprising a bone anchoring element ( | 12-19-2013 |
20130338721 | RECEIVING PART FOR RECEIVING A ROD FOR COUPLING THE ROD TO A BONE ANCHORING ELEMENT AND A BONE ANCHORING DEVICE WITH SUCH A RECEIVING PART - A receiving part for receiving a rod for coupling the rod to a bone anchoring element includes a receiving part body with a top end, a bottom end, a central axis, a channel for receiving a rod, and an accommodation space for accommodating a head of a bone anchoring element, the accommodation space having an opening at the bottom end for introduction of the head, and a single piece pressure element having a top end, a bottom end, and a flexible portion to clamp the head, wherein the flexible portion has a first slit extending partially around the central axis when the pressure element is in the receiving part body, and a second slit extending from the bottom end of the pressure element to the first slit. | 12-19-2013 |
20140012337 | POLYAXIAL BONE ANCHORING DEVICE - A polyaxial bone anchoring device includes an anchoring element having a shank and a head, a receiving part for receiving the head of the bone anchoring element and a rod, the receiving part including an upper member with a top end and a bottom end, a central axis extending through the top end and the bottom end, a head receiving portion with a passage at the bottom end for introducing the head, and a channel for receiving the rod at the top end, a lower member having a passage and being connectable to the upper member from the bottom end of the upper member, wherein at least one clamping member at or near the bottom end of the upper member is configured to reduce the diameter of the passage of the head receiving portion when the lower member is connected to the upper member to hold the head. | 01-09-2014 |
20140188180 | DYNAMIC BONE ANCHOR - A dynamic bone anchor is provided comprising a longitudinal core member ( | 07-03-2014 |
20150157367 | ROD INSERTION DEVICE FOR INSERTING A ROD INTO A BONE ANCHOR - A rod insertion device for inserting a rod into a bone anchor includes a shaft having a first end, a second end, and a shaft axis; a rod holding member connected to the first end of the shaft and configured to pivot relative to the shaft about a pivot axis and to receive a portion of a rod therein, the rod holding member comprising at least two recesses in an outer surface of the rod holding member and separated from each other along a circumferential direction about the pivot axis; a handle at the second end of the shaft; a locking member configured to lock an inserted rod in the rod holding member; and a detent member configured to selectively engage the rod holding member to latch a pivot position of the rod holding member relative to the shaft. | 06-11-2015 |
20150173810 | ROD INSERTION DEVICE - A rod insertion system and at least two bone anchors including: a rod guide configured to accommodate a spinal stabilization rod therein; a holding device including a clamping portion configured to hold a portion of the rod guide; and an adapter configured to moveably support the holding device. The holding device is configured to move and pivot along an adapter such that the rod guide is positioned proximal to a rod channel of one of the at least two bone anchors. In a first state, the rod guide is fixed to the holding device by the clamping portion, and, in a second state in which the holding device supports the portion of the rod guide, the clamping portion is released from the portion of the rod guide to permit the orientation of the rod guide relative to the holding device to be polyaxially adjusted. | 06-25-2015 |
20150182265 | EXTENSION DEVICE FOR A BONE ANCHOR, IN PARTICULAR FOR MINIMALLY INVASIVE SURGERY - An extension device for a bone anchor is provided, wherein the bone anchor comprises
| 07-02-2015 |
20150230938 | LENGTH ADJUSTABLE IMPLANT - An implant for the application m spinal or trauma surgery is provided that has a variable axial length, the implant including a first member and a second member guided relative to the first member to be movable relative thereto in an axial direction for adjusting an overall length of the implant; and at least one engagement member that is in a first configuration configured to engage the first member and the second member such that the first member and the second member are locked with respect to each other and in a second configuration configured to engage the first member such that the second member is movable with respect to the first member; wherein, in the second configuration, the engagement member is configured to be secured against disengagement from the first member by an abutment, and wherein the engagement member is a monolithic part. | 08-20-2015 |
20150257798 | DEVICE FOR PLACING A RECEIVING PART ONTO A HEAD OF A BONE ANCHORING ELEMENT - A device for placing a receiving part of a bone anchoring device onto a head of a bone anchoring element, comprising: a holding device, a collet having a longitudinal axis and being held by the holding device, wherein the collet includes a distal end portion configured to be flexibly expanded and/or compressed in a radial direction perpendicular to the longitudinal axis, wherein an engagement feature is provided at an outer contour of the distal end portion of the collet configured to engage a portion of an inner wall formed in a rod receiving channel or a bore of a receiving part. | 09-17-2015 |
20150359571 | EXTENSION DEVICE FOR A BONE ANCHOR, IN PARTICULAR FOR MINIMALLY INVASIVE SURGERY - An extension device for a bone anchor is provided, wherein the bone anchor comprises an anchoring section and a receiving part connected to the anchoring section, the receiving part having a central axis, the extension device comprising a first sleeve with a first sleeve axis that is coaxial to the central axis and being configured to be coupled to and decoupled from the receiving part; a second sleeve with a second sleeve axis coaxial to the central axis, being positioned within the first sleeve and positionable relative to the first sleeve along the central axis, and being configured to be coupled to and decoupled from the receiving part; a locking member that, in a first configuration, inhibits decoupling of the first sleeve or the second sleeve from the receiving part when the other one of the first sleeve or the second sleeve is coupled to the receiving part. | 12-17-2015 |
20160066957 | BONE ANCHORING DEVICE AND TOOL COOPERATING WITH SUCH A BONE ANCHORING DEVICE - A bone anchoring device includes a receiving part including a rod receiving portion with a first end, a second end, and a U-shaped recess for receiving a rod, the recess defining two free legs, and a head receiving portion at the second end for introducing and clamping the head, and a locking ring configured to be arranged around the head receiving portion, the locking ring including an engagement structure for engagement with a tool, the engagement structure defining a width of the locking ring that is greater than a greatest width of the rod receiving portion, wherein the locking ring can assume a locking position exerting a greatest compressive force on the head receiving portion of the receiving part to lock an inserted head, and wherein the locking ring is movable out of the locking position towards the first end of the rod receiving portion. | 03-10-2016 |