Beutner
Achim Beutner, Angered SE
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20090157247 | METHOD AND APPARATUS FOR USING AN AUTOMATED LANE KEEPING SYSTEM TO MAINTAIN LATERAL VEHICLE SPACING - A method and apparatus for piloting a vehicle is herein disclosed. The method entails first using a lane keeping system to detect objects in lanes adjacent to the lane currently occupied by the vehicle and then adjusting the position of the vehicle within the occupied lane-relative to a detected object. | 06-18-2009 |
Gregory Beutner, Green Brook, NJ US
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20130164794 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE - The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker. | 06-27-2013 |
Gregory L. Beutner, Green Brook, NJ US
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20130149751 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates. | 06-13-2013 |
20130178541 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel catiomc lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. | 07-11-2013 |
20130225836 | NOVEL LOW MOLECULAR WEIGHT CYCLIC AMINE CONTAINING CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. | 08-29-2013 |
20140206605 | CRYSTAL FORMS OF A HCV PROTEASE INHIBITOR - The present invention relates to different forms of a HCV inhibitory compound. | 07-24-2014 |
20140243519 | METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS - The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applica | 08-28-2014 |
Ingo Beutner, Gemuenden DE
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20140060950 | BICYCLE, IN PARTICULAR MOUNTAIN BIKE, WITH AN ELECTRICAL DRIVE - A bicycle has a main frame, a rear suspension having a spring and guiding a wheel along a prescribed path and an electric drive mounted on the main frame. A driving pinion thereof being is disposed coaxial to the shaft of a bottom bracket, and at least one driven pinion is disposed coaxial to the rear wheel and operationally connected to the driving pinion of the electric drive by a chain. A chain segment transmitting torque from the driving to the driven pinions is guided by a chain deflector. A distance between where the chain segment engages the driven pinion and the point of the chain deflector about which the chain is substantially pivoted when the wheel is deflected changes so slightly that the crank arms of the bottom bracket rotate by a maximum permissible angle relative to a non-deflected position of the wheel when the spring is deflected. | 03-06-2014 |
20150059513 | INSERT FOR SECURING CABLES, CABLE LINES AND WIRES IN A BICYCLE FRAME - An insert is removably fastened in an opening on a bicycle frame for securing cables, cable pulls, or lines routed through the opening. The insert includes a pass-through opening for the cable, the cable pull, or the line. The insert includes at least one thrust block to be inserted in the opening, by which the insert is supported in the region of the opening on the inner side of the bicycle frame after being inserted in the opening. The insert is removably fastened by at least one fastening element disposed at a distance from the thrust block such that the insert makes sealing contact at least in segments under pre-tension due to the interaction of the fastening element with the thrust block in the edge region transitioning into the peripheral contour of the underside of the insert facing the bicycle frame. | 03-05-2015 |
20150061257 | BICYCLE FRAME MADE OUT OF FIBER-REINFORCED MATERIAL COMPRISING AN ADAPTER PLATE FOR THE REAR WHEEL - The invention relates to a bicycle frame made of fiber-reinforced material, particularly of plastic reinforced with carbon fibers, having a rear wheel suspension for supporting the rear wheel. According to the invention, a receptacle is formed on at least one of the two chain stays of the rear wheel suspension, in which a replaceable adapter plate adapted to the hub of each rear wheel to be used is removably fastened, in which the axle of the rear wheel can be supported. | 03-05-2015 |
Sven Beutner, Frankfurt/main DE
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20110296640 | Bristle Holder for a Brush - The present invention relates to a brush and a bristle holder. The invention relates in particular to a bristle holder for a brush, the bristle holder having a frame, a bristle anchoring means, and a back part, the back part having a first end area adjacent to the handle part of a connectable brush and a second end area adjacent to the brush end, the first end area supporting at least one first connecting element and the second end area supporting at least one positioning element and at least one holding element. The invention furthermore relates to a brush with and for a bristle holder of the described type. | 12-08-2011 |
Sven Beutner, Frankfurt Am Main DE
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20120305794 | Apparatus for Counting Ions, and Method for Counting Ions - An apparatus for counting the number of ions emitted by an ion source of a handheld domestic appliance is disclosed. The apparatus includes a collector housing for collecting ions impinging on the inner surface of the collector housing and a determining means coupled with the collector housing for determining the number of ions collected by the collector housing. The collector housing has an input opening dimensioned such that the domestic appliance is at least partially insertable into the collector housing via input opening. A method for counting the number of ions emitted by an ion source of a handheld domestic appliance is also disclosed. | 12-06-2012 |