Patent application number | Description | Published |
20090137837 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF - Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods. | 05-28-2009 |
20100280255 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein. | 11-04-2010 |
20110160463 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES - The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R | 06-30-2011 |
20110281954 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF - Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods. | 11-17-2011 |
Patent application number | Description | Published |
20090248883 | APPARATUS AND METHODS FOR MANAGING WIDGETS IN A WIRELESS COMMUNICATION ENVIRONMENT - Apparatus and methods relating to mobile widgets. In particular, apparatus and methods for integrating network services and/or network resources with widget capabilities, managing mobile widgets, providing portability to mobile widgets, and generating content with respect to a mobile widget. In one aspect, a method for integration of network services and/or resources with widget capabilities is provided. The method may include providing for an interface between a widget management component and at least one of a network resource or a network service. The method may also include accessing, at the widget management component via the interface, at least one of a network resource or network service. Further, the method may include integrating the network resource or the network service with a widget functionality. | 10-01-2009 |
20090248996 | APPARATUS AND METHODS FOR WIDGET-RELATED MEMORY MANAGEMENT - Apparatus and methods for changing operational modes of a widget and changing content feed to a widget based on operational mode changes and/or memory availability on the wireless device are provided. Apparatus and methods for managing the runtime memory usage of mobile widgets on a wireless device by changing widget states based on widget usage data are also provided. | 10-01-2009 |
20090249321 | APPARATUS AND METHODS FOR WIDGET UPDATE SCHEDULING - Methods and apparatus for scheduling a content update of a mobile widget are provided. The method may include receiving a widget update consideration. The method may also include generating a content update schedule for a mobile widget based on the update consideration. Further, the method may include storing the generated content update schedule for use in updating a content of the mobile widget. | 10-01-2009 |
20090271778 | APPARATUS AND METHODS FOR TRANSPORT OPTIMIZATION FOR WIDGET CONTENT DELIVERY - Apparatus and methods for transport optimization for widget content delivery includes obtaining updated content corresponding to a mobile widget having a plurality of informational hierarchical depths, and obtaining user navigation pattern historical data corresponding to the mobile widget, wherein the user navigation pattern historical data corresponds to the plurality of informational hierarchical depths. The aspects also include obtaining a first informational hierarchical depth range for inclusion in a first content update message for delivery to a device, wherein the first informational hierarchical depth range is based on the user navigation pattern historical data. Further, the aspects include generating a content update message with a first portion of the updated content corresponding to the first informational hierarchical depth range. Optionally, the aspects further include reducing a size of the first portion of the updated content in the first content update message, thereby defining a first compressed portion of the updated content. | 10-29-2009 |
20150248231 | APPARATUS AND METHODS FOR WIDGET-RELATED MEMORY MANAGEMENT - Apparatus and methods for changing operational modes of a widget and changing content feed to a widget based on operational mode changes and/or memory availability on the wireless device are provided. Apparatus and methods for managing the runtime memory usage of mobile widgets on a wireless device by changing widget states based on widget usage data are also provided. | 09-03-2015 |
20150346993 | APPARATUS AND METHODS FOR MANAGING WIDGETS IN A WIRELESS COMMUNICATION ENVIRONMENT - Apparatus and methods relating to mobile widgets. In particular, apparatus and methods for integrating network services and/or network resources with widget capabilities, managing mobile widgets, providing portability to mobile widgets, and generating content with respect to a mobile widget. In one aspect, a method for integration of network services and/or resources with widget capabilities is provided. The method may include providing for an interface between a widget management component and at least one of a network resource or a network service. The method may also include accessing, at the widget management component via the interface, at least one of a network resource or network service. Further, the method may include integrating the network resource or the network service with a widget functionality. | 12-03-2015 |
Patent application number | Description | Published |
20110173345 | Method and system for HTTP-based stream delivery - A method of delivering a live stream is implemented within a content delivery network (CDN) and includes the high level functions of recording the stream using a recording tier, and playing the stream using a player tier. The step of recording the stream includes a set of sub-steps that begins when the stream is received at a CDN entry point in a source format. The stream is then converted into an intermediate format (IF), which is an internal format for delivering the stream within the CDN and comprises a stream manifest, a set of one or more fragment indexes (FI), and a set of IF fragments. The player process begins when a requesting client is associated with a CDN HTTP proxy. In response to receipt at the HTTP proxy of a request for the stream or a portion thereof, the HTTP proxy retrieves (either from the archive or the data store) the stream manifest and at least one fragment index. Using the fragment index, the IF fragments are retrieved to the HTTP proxy, converted to a target format, and then served in response to the client request. The source format may be the same or different from the target format. Preferably, all fragments are accessed, cached and served by the HTTP proxy via HTTP. In another embodiment, a method of delivering a stream on-demand (VOD) uses a translation tier (in lieu of the recording tier) to manage the creation and/or handling of the IF components. | 07-14-2011 |
20110296048 | Method and system for stream handling using an intermediate format - A method of delivering a live stream is implemented within a content delivery network (CDN) and includes the high level functions of recording the stream using a recording tier, and playing the stream using a player tier. The step of recording the stream includes a set of sub-steps that begins when the stream is received at a CDN entry point in a source format. The stream is then converted into an intermediate format (IF), which is an internal format for delivering the stream within the CDN and comprises a stream manifest, a set of one or more fragment indexes (FI), and a set of IF fragments. The player process begins when a requesting client is associated with a CDN HTTP proxy. In response to receipt at the HTTP proxy of a request for the stream or a portion thereof, the HTTP proxy retrieves (either from the archive or the data store) the stream manifest and at least one fragment index. Using the fragment index, the IF fragments are retrieved to the HTTP proxy, converted to a target format, and then served in response to the client request. The source format may be the same or different from the target format. Preferably, all fragments are accessed, cached and served by the HTTP proxy via HTTP. | 12-01-2011 |
20150249854 | Method and system for recording streams - A method of delivering a live stream includes recording the stream using a recording tier, and playing the stream using a player tier. The step of recording the stream includes sub-steps that begin when the stream is received in a source format. The stream is then converted into an intermediate format (IF), which is an internal format for delivering the stream within an overlay network. The player process begins when a requesting client is associated with a network proxy. In response to receipt at the proxy of a request for the stream or a portion thereof, the proxy retrieves (either from the archive or the data store) a stream manifest and at least one fragment index. Using the fragment index, the intermediate format file fragments are retrieved to the proxy, converted to a target format, and then served in response to the client request. | 09-03-2015 |
Patent application number | Description | Published |
20100016828 | Drug Delivery System and Method - A method for delivering a therapeutic agent to a predetermined location in a host is disclosed, wherein a liposome-encapsulated therapeutic agent is administered to the host, and an electrical field which encompasses a predetermined region within the host is established, such that as the liposome-encapsulated agent is exposed to the electrical field the release of the agent from the liposome to the predetermined region is enhanced. | 01-21-2010 |
20110288467 | METHOD AND APPARATUS FOR DELIVERY OF THERAPEUTIC AGENTS - Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention includes controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes. | 11-24-2011 |
20120078161 | Apparatus for electrically mediated delivery of therapeutic agents - Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state. | 03-29-2012 |
20120277661 | METHOD AND APPARATUS FOR DELIVERY OF THERAPEUTIC AGENTS - Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes. | 11-01-2012 |