Atsushi Sugiyama
Atsushi Sugiyama, Fuefuki-Shi JP
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20100173351 | CARDIAC REENTRY MODEL CHIP AND APPARATUS AND METHOD FOR EVALUATING DRUG USING THE CARDIAC REENTRY MODEL CHIP - A chip has been developed that can accurately measure cell potential and cell morphology on a single cell basis. The chip also constitutes a cardiac model that comprises a closed loop whereupon cardiomyocytes and fibroblasts are suitably dispersed and arranged, and that can evaluate the effects of a drug thereon. An in vitro cardiac reentry model chip is fabricated by constructing a closed loop comprising cardiomyocytes and fibroblasts arrayed on transparent electrodes formed on a transparent substrate by using a constitution where single cells are enclosed in a specific spatial configuration. A pulse wave of a random cardiomyocyte or a specific cardiomyocyte is propagated on both sides of the loop, and the pulsation status of the cells in the loop is detected electrically. A drug is applied to this cardiac reentry model chip, and the benefit or toxicity of the drug to cardiomyocytes is evaluated by measuring the cell potentials of individual cells. | 07-08-2010 |
20100178692 | MODEL CELL CHIP, APPARATUS FOR EVALUATING DRUG EFFECT USING THE MODEL CELL CHIP AND METHOD OF EVALUATING DRUG EFFECT - The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo. | 07-15-2010 |
Atsushi Sugiyama, Yamanashi JP
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20090263324 | Animal Model With Induced Arrhythmia - Provided are a model animal physiologically similar to humans, enabling a highly reproducible evaluation of the onset of drug-induced long QT syndrome, a method of generating the same, and an evaluating method using the same. A proarrhythmia model animal of a monkey, prepared by ablating the atrioventricular node; the foregoing monkey is preferably a cynomolgus monkey. A method of generating a proarrhythmia model animal, comprising a step for inserting an electrode catheter to the heart of a monkey, and ablating atrioventricular node with the catheter, and a method of evaluating the QT interval prolongation by a drug, comprising using the foregoing model animal. | 10-22-2009 |
Atsushi Sugiyama, Hamamatsu-Shi JP
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20080219312 | QUANTUM CASCADE LASER DEVICE - In a quantum cascade laser device | 09-11-2008 |
20090052488 | QUANTUM CASCADE LASER ELEMENT - A DFB quantum cascade laser element that can reliably CW-oscillate a single-mode light even at room temperature or a temperature in proximity thereof is provided. In a quantum cascade laser element | 02-26-2009 |
20130322479 | QUANTUM CASCADE LASER - A quantum cascade laser includes a semiconductor substrate, and an active layer that is provided on the substrate, and has a cascade structure in which emission layers and injection layers are alternately laminated by multistage-laminating unit laminate structures each consisting of the quantum well emission layer and the injection layer, the active layer generates light by intersubband transition in a quantum well structure. Further, in a laser cavity structure for light with a predetermined wavelength to be generated in the active layer, reflection control films including at least one layer of CeO | 12-05-2013 |
20130322480 | QUANTUM CASCADE LASER - A quantum cascade laser includes a semiconductor substrate, and an active layer that is provided on the substrate, and has a cascade structure in which emission layers and injection layers are alternately laminated by multistage-laminating unit laminate structures each consisting of the quantum well emission layer and the injection layer, and generates light by intersubband transition in a quantum well structure. Further, in a laser cavity structure for light with a predetermined wavelength to be generated in the active layer, CeO | 12-05-2013 |
20140199798 | QUANTUM CASCADE LASER MANUFACTURING METHOD - A quantum cascade laser manufacturing method includes: a step of pressing a mother stamper against a resin film having flexibility to make a resin stamper | 07-17-2014 |
20140241392 | QUANTUM CASCADE LASER - A quantum cascade laser | 08-28-2014 |
Atsushi Sugiyama, Shinjuku-Ku JP
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20110195277 | HIGH DENSITY MAGNETIC RECORDING MEDIUM AND MANUFACTURING METHOD THEREOF - A high density magnetic recording medium including aggregates of magnetic nanoparticles arranged stably and efficiently in demarcated sections in the surface of a substrate is manufactured by the steps of forming a plurality of parallel tracks in the surface of the substrate, forming a plurality of minute recesses serially at approximately equal intervals in each of the tracks, casting a liquid dispersion of magnetic nanoparticles into the minute recesses, and evaporating dispersing medium from the liquid dispersion, thereby forming an aggregate of magnetic nanoparticles in each of the minute recesses. | 08-11-2011 |
Atsushi Sugiyama, Bunkyo-Ku JP
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20110262958 | DEVICE FOR EXAMINING MYOCARDIAL TOXICITY, CHIP FOR EXAMINING MYOCARDIAL TOXICITY AND METHOD FOR EXAMINING MYOCARDIAL TOXICITY - [Problem] To provide a device and a method for examining myocardial toxicity, which can be realized in vitro in an equivalent manner as those conventionally carried out in vivo. | 10-27-2011 |
Atsushi Sugiyama, Kawaguchi-Shi JP
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20120300339 | MAGNETIC RECORDING MEDIUM AND METHOD OF MANUFACTURING THE SAME, AND MAGNETIC RECORD/REPRODUCTION APPARATUS - According to the present invention, a magnetic recording medium is provided including a disk-shaped non-magnetic substrate and at least a perpendicular magnetic layer formed on the disk-shaped non-magnetic substrate, wherein the perpendicular magnetic layer has a structure in which an FePt or CoPt nanoparticle array is formed on a formation surface, on which a plurality of striations each having a circumferential directional component are formed, by a texturing treatment; a manufacturing method thereof; and a magnetic record/reproduction apparatus including the magnetic recording medium or a magnetic recording medium manufactured according to the manufacturing method. | 11-29-2012 |
Atsushi Sugiyama, Susono-Shi JP
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20140027002 | CORRUGATED TUBE - The corrugated tube includes a body in which a plurality of peaks and a plurality of valleys are continuously alternated in a longitudinal direction of the body. A slit is formed in the body along the longitudinal direction. Both end portions of the body between which the slit is interposed are overlapped. A mark is provided to only one peak of the plurality of peaks at the one end portion of the body, and another mark is also provided to corresponding only one peak of the plurality of peak disposed at the other end portion of the body and brought into a fitting engagement with the marked peak disposed at the one end portion of the body. | 01-30-2014 |