Patent application number | Description | Published |
20110070110 | PIEZOELECTRIC MICRO BLOWER - A piezoelectric micro blower includes a blower body that includes a first wall and a second wall. An opening is provided at a portion of the first wall that faces an area of the approximate center of a driver of the piezoelectric micro blower. An opening is provided at a portion of the second wall. A central space that is in communication with the openings is provided between the first and second walls. Inlet passages through which the central space is in communication with the outside are provided between the first and second walls. Bottleneck portions are provided at regions at which the inlet passages are connected to the central space. The driver vibrates when a voltage is applied to a piezoelectric element. The first wall vibrates in a corresponding manner as the driver vibrates. | 03-24-2011 |
20120171062 | FLUID PUMP - A small-sized, low-profile fluid pump having high pumping capabilities includes an actuator and a planar section including a metal plate. The actuator includes a disk-shaped piezoelectric element attached to a disk-shaped diaphragm. As a result of application of a square-wave or sine-wave drive voltage, the actuator performs a bending vibration from the central portion to the peripheral portion. The peripheral portion of the actuator is not restrained. The actuator performs a bending vibration in the state in which it is in proximity to the planar section while facing the planar section. A center vent is provided at or in an area adjacent to the center of an actuator facing area of the planar section that faces the actuator. | 07-05-2012 |
20130058809 | FLUID CONTROL DEVICE - A fluid control device includes a vibrating plate unit, a driver, and a flexible plate. The vibrating plate unit includes a vibrating plate including a first main surface and a second main surface, and a frame plate surrounding the surroundings of the vibrating plate. The driver is provided on the first main surface of the vibrating plate, and vibrates the vibrating plate. The flexible plate has a hole formed thereon. Furthermore, the flexible plate faces the second main surface of the vibrating plate, and adheres to the frame plate by the adhesive agent that contains a plurality of particles arranged such that the plurality of particles are interposed between the flexible plate and the vibrating plate. | 03-07-2013 |
20130058810 | FLUID CONTROL DEVICE - A fluid control device includes a vibrating plate unit, a driver, a flexible plate, and a base plate. The vibrating plate unit includes a vibrating plate including first and second main surfaces, and a frame plate surrounding the surrounding of the vibrating plate. The driver is bonded to the first or the second main surface of the vibrating plate and vibrates the vibrating plate. The flexible plate includes a hole provided therein, and is bonded to the frame plate so as to face the vibrating plate. The base plate is bonded to the main surface of the flexible plate on a side opposite to the vibrating plate. A size relationship between the coefficients of linear expansion of the material of the base plate and the frame plate is equal to a size relationship between the coefficients of linear expansion of the material of the vibrating plate and the driver. | 03-07-2013 |
20130058818 | FLUID CONTROL DEVICE - A fluid control device includes a vibrating plate unit, a driver, and a flexible plate. The vibrating plate unit includes a vibrating plate with first and second main surfaces, a frame plate surrounding the vibrating plate, and a link portion linking the vibrating plate and the frame plate and elastically supporting the vibrating plate against the frame plate. The driver is on the first main surface of the vibrating plate, and vibrates the vibrating plate. The flexible plate having a hole faces the second main surface of the vibrating plate, being fixed to the frame plate. At least a portion of the vibrating plate and the link portion are thinner than the thickness of the frame plate so that the surface of the portion of the vibrating plate and the link portion, on the side of the flexible plate, can separate from the flexible plate. | 03-07-2013 |
20130058819 | FLUID CONTROL DEVICE - A fluid control device includes a vibrating plate including a first main surface and a second main surface, a driver that is provided on the first main surface of the vibrating plate and vibrates the vibrating plate, and a plate that is provided on the second main surface of the vibrating plate and has a hole provided thereon. At least one of either the vibrating plate or the plate is positioned between the hole and a region of the vibrating plate facing the hole, and includes a projection projecting in a direction intermediate between the hole and the region of the vibrating plate facing the hole. | 03-07-2013 |
20130071269 | PIEZOELECTRIC MICRO-BLOWER - A piezoelectric micro-blower includes a blower chamber located between a blower body and a vibrating plate, a first wall portion of the blower body arranged to face the vibrating plate across the blower chamber so as to vibrate with vibrations of the vibrating plate, a first opening in the first wall portion, a second wall portion on the opposite side of the first wall portion with respect to the blower chamber, a second opening in a portion of the second wall portion which faces the first opening, and an inflow passage located between the first wall portion and the second wall portion. Each of the first and second openings includes a plurality of holes, and each hole of the first opening and each hole of the second opening are arranged to face each other. Thus, noise is significantly reduced while the flow characteristic is maintained. | 03-21-2013 |
20130178752 | VALVE, FLUID CONTROL DEVICE - In a fluid control device, a check valve includes a first valve housing and a first diaphragm. The first diaphragm defines a first valve chamber and a second valve chamber. An exhaust valve includes a second valve housing and a second diaphragm. The second diaphragm defines a third valve chamber and a fourth valve chamber. The check valve is opened and closed by a difference in pressure between the first valve chamber and the second valve chamber. The exhaust valve is opened and closed by a difference in pressure between the third valve chamber and the fourth valve chamber. | 07-11-2013 |
20130255801 | FLUID SUPPLY DEVICE - A fluid supply device includes a fluid supply source, a valve, a differential-pressure generator, and a pressurizing device. The valve includes a casing, a displacement member that divides an inside of the casing into a first valve chamber and a second valve chamber, the displacement member being displaced by a pressure of a fluid being exerted on a front main surface and a back main surface of the displacement member, a first opening provided in the first valve chamber, a second opening provided in the first valve chamber, and a third opening provided in the second valve chamber. Thus, flow rate fluctuations are reduced even when the pressure on the ejection side or the suction side of the device fluctuates due to changes in atmospheric conditions. | 10-03-2013 |
20130266461 | ACTUATOR SUPPORT STRUCTURE AND PUMP DEVICE - A piezoelectric pump includes a leaf spring including a disc portion defining an actuator, an outer frame portion defining a housing, and an elastic support portion. The actuator flexurally vibrates from a center portion of a principal surface thereof to an outer periphery thereof. The elastic support portion includes a beam portion and connection portions and elastically supports the disc portion on the outer frame portion. The beam portion extends in a gap between the disc portion and the outer frame portion in a direction along an outer periphery of the disc portion. A first of the connection portions connects the beam portion to the disc portion. Second and third connection portions are offset from the first connection portion and connect the beam portion to the outer frame portion. | 10-10-2013 |
20130323085 | FLUID CONTROL APPARATUS AND METHOD FOR ADJUSTING FLUID CONTROL APPARATUS - In a method for adjusting a fluid control apparatus, in a pressing step, a piezoelectric pump is placed on a stage with a cover plate facing upward, the stage is moved up, and a center portion of a principal surface of the cover plate on a side opposite to a diaphragm is pressed with a pressing pin. As a result, the cover plate and the base plate are shaped so as to warp convexly toward the diaphragm side, and a portion joined to a flexible plate is pulled, such that the flexible plate is caused to warp convexly toward the diaphragm side. Thus, residual tensile stress occurs in a movable portion of the flexible plate. Therefore, due to the residual tensile stress, the tensile stress of the movable portion of the flexible plate is increased. | 12-05-2013 |
20140286795 | GAS CONTROL APPARATUS - A gas control apparatus includes an upper housing to which a second piezoelectric pump is joined, a lower housing to which a first piezoelectric pump is joined, and a diaphragm. The upper housing includes a discharge hole through which gas is discharged. The lower housing includes introduction holes through which gas is introduced, an opening, a first valve seat, a second valve seat, and a third valve seat. The diaphragm is sandwiched between the upper housing and the lower housing, and is fixed to the upper housing and the lower housing so that the diaphragm contacts the first valve seat, the second valve seat, and the third valve seat. The diaphragm divides an inner space of the upper housing and the lower housing to define valve chests together with the upper housing and the lower housing. | 09-25-2014 |
20150034847 | VALVE AND FLUID CONTROL APPARATUS - A valve includes a lower valve housing, a diaphragm, and an upper valve housing. A top surface of a piezoelectric pump is bonded to a bottom surface of the lower valve housing. A circular hole portion is provided in a central portion of a region of the diaphragm that opposes a projecting portion of the lower valve housing. The diaphragm is bonded to the upper valve housing and the lower valve housing, and a divided interior of a valve housing configures a first lower valve chamber, a second lower valve chamber, a first upper valve chamber, and a second upper valve chamber. A groove is located in a wall portion of the upper valve housing that opposes the diaphragm in the first upper valve chamber. | 02-05-2015 |
20150056087 | FLUID CONTROL DEVICE - A fluid control device includes a vibrating plate unit, a driver, and a flexible plate. The vibrating plate unit includes a vibrating plate with first and second main surfaces, a frame plate surrounding the vibrating plate, and a link portion linking the vibrating plate and the frame plate and elastically supporting the vibrating plate against the frame plate. The driver is on the first main surface of the vibrating plate, and vibrates the vibrating plate. The flexible plate having a hole faces the second main surface of the vibrating plate, being fixed to the frame plate. At least a portion of the vibrating plate and the link portion are thinner than the thickness of the frame plate so that the surface of the portion of the vibrating plate and the link portion, on the side of the flexible plate, can separate from the flexible plate. | 02-26-2015 |
20150060012 | COOLING DEVICE AND HEATING AND COLLING APPARATUS - An analyzing device includes a heating device, a cooling device, and a controller. The cooling device includes a piezoelectric pump, a check valve, an exhaust valve, and an air tank. The analyzing device heats a subject by the heating device. The cooling device drives the piezoelectric pump while the heating device heating the subject. With this, the outside air is sucked through a suction port and the air that is discharged from the piezoelectric pump is accommodated in the air tank through the check valve. Then, the pressure in the air tank is increased. Thereafter, the cooling device stops driving of the piezoelectric pump. With this, the air in the air tank is discharged toward the subject via the exhaust valve so as to cool the subject. | 03-05-2015 |
20150096638 | VALVE, FLUID CONTROL DEVICE - In a fluid control device, a check valve includes a first valve housing and a first diaphragm. The first diaphragm defines a first valve chamber and a second valve chamber. An exhaust valve includes a second valve housing and a second diaphragm. The second diaphragm defines a third valve chamber and a fourth valve chamber. The check valve is opened and closed by a difference in pressure between the first valve chamber and the second valve chamber. The exhaust valve is opened and closed by a difference in pressure between the third valve chamber and the fourth valve chamber. | 04-09-2015 |
Patent application number | Description | Published |
20110098450 | Antibody Molecules - The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions. | 04-28-2011 |
20110111406 | ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY - The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. | 05-12-2011 |
20110245473 | Anti-IL-6 Receptor Antibody - The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations. | 10-06-2011 |
20120065379 | Antibody Constant Region Variant - By means of amino acid sequence alterations, the present inventors succeeded in providing constant regions that can confer antibodies with favorable properties, particularly as pharmaceuticals. The variants of the constant regions provided by the present invention will remarkably reduce heterogeneity when applied to antibody production. That is, homogeneity of antibodies can be maintained at a high level by introducing the alterations provided by the present invention into the antibody heavy chain constant regions. More specifically, decrease in homogeneity caused by —SS— bond linkage differences in the heavy chains of antibody molecules can be prevented. Furthermore, in a preferred embodiment of the present invention, pharmacokinetics of antibodies can be improved and decrease in homogeneity caused by deletion of the C terminus in the antibody constant region can be ameliorated. | 03-15-2012 |
20120071634 | Antibody Constant Region Variant - By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region. | 03-22-2012 |
20120121587 | ANTI-AXL ANTIBODY - An objective of the present invention is to decrease the immunogenicity of mouse-derived anti-AXL antibodies in humans by humanizing them. The present invention provides antibodies that can bind to a specific region in Anexelekto (AXL) and humanized antibodies that are produced based on such antibodies. The anti-AXL antibodies of the present invention have high antitumor activity, and are useful as agents for decreasing the AXL expression level, antitumor agents, and diagnostic agents for cancer. | 05-17-2012 |
20120238729 | Modified Antibody Constant Regions - The present inventors successfully provided constant regions capable of enhancing the agonist activity of antibodies through amino acid sequence alterations. Specifically, agonist activity was found to be enhanced in antibodies having a constant region in which amino acids of the antibody heavy chain constant region are substituted or deleted, or antibodies having a constant region in which the hinge region amino acids are substituted. Use of such antibodies as pharmaceutical formulations can provide pharmaceutical formulations with improved performance. | 09-20-2012 |
20120253016 | ANTIBODY MOLECULES THAT BIND TO IL-6 RECEPTOR - The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions. | 10-04-2012 |
20130011866 | ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY - The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. | 01-10-2013 |
20130101581 | ANTIBODY CONSTANT REGION VARIANT - The present inventors carried out dedicated research to generate antibody constant regions with reduced Fcγ receptor-binding activity by altering amino acid sequences in the antibody constant region. As a result, the present inventors successfully identified novel constant region sequences with reduced Fcγ receptor-binding activity compared to conventional antibody constant regions. | 04-25-2013 |
20130131319 | ANTIBODIES WITH MODIFIED AFFINITY TO FCRN THAT PROMOTE ANTIGEN CLEARANCE - An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies. | 05-23-2013 |
20130303396 | ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY - The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. | 11-14-2013 |
20130317203 | Anti-IL-6 Receptor Antibody - The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations. | 11-28-2013 |
20130336963 | ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY - The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. | 12-19-2013 |
20140105889 | METHOD FOR ALTERING PLASMA RETENTION AND IMMUNOGENICITY OF ANTIGEN-BINDING MOLECULE - The present invention demonstrated that the modification of the Fc region of an antigen-binding molecule into an Fc region that does not form in a neutral pH range a heterotetramer complex containing two molecules of FcRn and an active Fcγ receptor improved the pharmacokinetics of the antigen-binding molecule and reduced the immune response to the antigen-binding molecule. The present invention also revealed methods for producing antigen-binding molecules having the properties described above, and successfully demonstrated that pharmaceutical compositions containing as an active ingredient such an antigen-binding molecule or an antigen-binding molecule produced by a production method of the present invention have excellent features over conventional antigen-binding molecules in that when administered, they exhibit improved pharmacokinetics and reduced in vivo immune response. | 04-17-2014 |
20140234340 | ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO PLURALITY OF ANTIGEN MOLECULES REPEATEDLY - An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction. | 08-21-2014 |
20140255398 | ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN - The present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced. Furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that express the antigen to which the antigen-binding molecule binds. | 09-11-2014 |
20140335089 | ANTIGEN-BINDING MOLECULE FOR PROMOTING ELIMINATION OF ANTIGENS - The present inventors created antigen-binding molecules containing an antigen-binding domain and an Fcγ-receptor-binding domain, wherein the molecules have human-FcRn-binding activity in an acidic pH range condition, the antigen-binding domain changes the antigen-binding activity of the antigen-binding molecules depending on the ion-concentration condition, and the Fcγ receptor-binding domain has higher binding activity to the Fcγ receptor in a neutral pH range condition than an Fc region of a native human IgG in which the sugar chain bound at position 297 (EU numbering) is a fucose-containing sugar chain. | 11-13-2014 |
20140363428 | THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE - The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules. | 12-11-2014 |
20150050269 | ANTIGEN-BINDING MOLECULE PROMOTING DISAPPEARANCE OF ANTIGENS HAVING PLURALITY OF BIOLOGICAL ACTIVITIES - The present inventors newly discovered that even if an antigen-binding molecule inhibits in vitro some of the physiological activities of an antigen having two or more physiological activities without inhibiting the remaining physiological activities, the molecule can promote elimination of the antigen from blood (from serum or plasma) and as a result reduce the physiological activities in vivo, when the antigen-binding molecule is conferred with the properties: (i) of binding to human FcRn under an acidic pH range condition; (ii) of binding under a neutral pH range condition to human Fc receptor stronger than native human IgG, and (iii) that its antigen-binding activity alters according to the ion concentration. | 02-19-2015 |
20150110793 | Humanized Anti-Epiregulin Antibody, and Cancer Therapeutic Agent Comprising Said Antibody as Active Ingredient - The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed chemical degradation, anti-Epiregulin antibodies with lowered isoelectric point, anti-Epiregulin antibodies with increased thermal denaturation midpoint temperature, and anti-Epiregulin antibodies with reduced amount of aggregate by performing appropriate amino acid residue substitutions in the variable-region sequences of the humanized EP27 antibody which inhibits growth of cancer cells by exhibiting cytotoxic activity and neutralizing activity against human Epiregulin-expressing cancer cells. | 04-23-2015 |
20150210763 | MODIFIED Fc REGION OF ANTIBODY - Polypeptides with improved stability as compared to that of a parent polypeptide were successfully obtained by modifying at least one amino acid in a loop region of the antibody Fc region. Furthermore, by combining multiple amino acid modifications in the loop region, polypeptides with maintained or enhanced FcγR-binding activity as well as improved thermal stability, polypeptides with decreased FcγR-binding activity as well as improved thermal stability, and polypeptides with not only improved thermal stability and adjusted FcγR-binding activity but also decreased aggregate content, as compared to those of a parent polypeptide, were successfully obtained. | 07-30-2015 |
20150274809 | ANTIBODY CONSTANT REGION VARIANT - By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region. | 10-01-2015 |
20160046693 | Antigen-Binding Molecule for Promoting Disappearance of Antigen via Fc gamma RIIB - The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an FcγR-binding domain having Fcγ RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule. | 02-18-2016 |
Patent application number | Description | Published |
20090240015 | DIOL (METH) ACRYLATE COMPOUND HAVING URETHANE BOND, METHOD FOR PRODUCING THE SAME, AND POLYMER THEREOF - The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): | 09-24-2009 |
20090247718 | DIOL (METH) ACRYLATE COMPOUND HAVING URETHANE BOND, METHOD FOR PRODUCING THE SAME, AND POLYMER THEREOF - The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): | 10-01-2009 |
20100040697 | COSMETIC PRODUCT, NANOPARTICLES FOR COSMETICS, AND POWDER FOR COSMETICS - The invention provides a cosmetic product which has a good texture and allows full expression of the inherent functions of ceramide as an intercellular lipid, such as skin barrier function and hair protection effect, as well as nanoparticles for cosmetics and powder for cosmetics which may be used in the above cosmetic product, exhibit good skin barrier function and hair protection effect, and are easy to incorporate into the above cosmetic product. The cosmetic product, the nanoparticles, and the powder for cosmetics according to the present invention contain a polymer obtained by polymerization of a monomer material containing a glycerol (meth)acrylate monomer represented by the formula (1): | 02-18-2010 |
20100081779 | DIOL (METH) ACRYLATE COMPOUND HAVING URETHANE BOND, METHOD FOR PRODUCING THE SAME, AND POLYMER THEREOF - The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): | 04-01-2010 |
20100081780 | DIOL (METH) ACRYLATE COMPOUND HAVING URETHANE BOND, METHOD FOR PRODUCING THE SAME, AND POLYMER THEREOF - The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): | 04-01-2010 |
20120276179 | COSMETIC PRODUCT, NANOPARTICLES FOR COSMETICS, AND POWDER FOR COSMETICS - The invention provides a cosmetic product which has a good texture and allows full expression of the inherent functions of ceramide as an intercellular lipid, such as skin barrier function and hair protection effect, as well as nanoparticles for cosmetics and powder for cosmetics which may be used in the above cosmetic product, exhibit good skin barrier function and hair protection effect, and are easy to incorporate into the above cosmetic product. The cosmetic product, the nanoparticles, and the powder for cosmetics according to the present invention contain a polymer obtained by polymerization of a monomer material containing a glycerol(meth)acrylate monomer represented by the formula (1): | 11-01-2012 |
Patent application number | Description | Published |
20110155438 | Multilayer Wiring Substrate - A multilayer wiring substrate has a multilayer wiring laminate portion in which a plurality of resin insulation layers made primarily of the same resin insulation material, and a plurality of conductive layers are laminated alternately. A plurality of first-main-surface-side connection terminals are disposed on one side of the laminate structure where a first main surface thereof is present, and a plurality of second-main-surface-side connection terminals being disposed on an other side of the laminate structure where a second main surface thereof is present. The plurality of conductive layers are formed in the plurality of resin insulation layers and interconnected by means of via conductors whose diameters increase toward the first main surface or the second main surface. The plurality of first-main-surface-side connection terminals comprising at least two types of terminals for connection of different articles-to-be-connected. Top surfaces of the plurality of first-main-surface-side connection terminals differ in height according to types of the articles-to-be-connected. | 06-30-2011 |
20110155443 | Method of Manufacturing Multilayer Wiring Substrate, and Multilayer Wiring Substrate - In a build-up step, a plurality of resin insulation layers and a plurality of conductive layers are alternately laminated in multilayer arrangement on a metal foil separably laminated on a side of a base material, thereby forming a wiring laminate portion. In a drilling step, a plurality of openings are formed in an outermost resin insulation layer through laser drilling so as to expose connection terminals. Subsequently, in a desmear step, smears from inside the openings are removed. In a base-material removing step performed after the build-up step, the base material is removed and the metal foil is exposed. | 06-30-2011 |
20110156272 | Multilayered Wiring Substrate - A multilayered wiring substrate, comprising: a plurality of first main surface side connecting terminals arranged in a first main surface of a stack structure; and a plurality of second main surface side connecting terminals being arranged in a second main surface of the stack structure; wherein a plurality of conductor layers are alternately formed in a plurality of stacked resin insulation layers and are operably connected to each other through via conductors tapered such that diameters thereof are widened toward the first or the second main surface, wherein a plurality of openings are formed in an exposed outermost resin insulation layer in the second main surface, and terminal outer surfaces of the second main surface side connecting terminals arranged to match with the plurality of the openings are positioned inwardly from an outer main surface of the exposed outermost resin insulation layer, and edges of terminal inner surfaces are rounded. | 06-30-2011 |
20120111616 | ELECTRONIC-COMPONENT-MOUNTED WIRING SUBSTRATE AND METHOD OF MANUFACTURING THE SAME - An electronic-component-mounted wiring substrate provides enhanced joining reliability when an electronic component is joined to terminal pads of the wiring substrate, has sufficient strength, and can prevent generation of warpage and formation of a short circuit, which would otherwise occur as a result of re-melting of solder. Solder completely covers an entire surface of each of the terminal pads provided on a laminated substrate such that they project therefrom, and also joins to terminals of the electronic component. Therefore, each of the terminal pads and the solder are joined together reliably, and sufficient electrical continuity is secured therebetween. That is, the reliability of a joint between the solder and each terminal pad is extremely high, and the reliability of joint between the terminal pads and the electronic component is extremely high. | 05-10-2012 |
20120186857 | METHOD FOR MANUFACTURING WIRING BOARD FOR MOUNTING ELECTRONIC COMPONENT, WIRING BOARD FOR MOUNTING ELECTRONIC COMPONENT, AND METHOD FOR MANUFACTURING WIRING BOARD HAVING AN ELECTRONIC COMPONENT - A method for manufacturing a wiring board for mounting an electronic component, a wiring board for mounting an electronic component, and a method for manufacturing an electronic-component-mounted wiring board are provided. A bonding material paste, which can include solder and an electric insulation material made of a resin, can be placed on chip mount terminal pads and heated to fuse the solder and soften the electric insulation material. Subsequently, the solder is solidified to form solder bumps. Further, the electric insulation material is cured on a surface of each of the solder bumps and a surface of a multilayer board around each of the solder bumps to form an electric insulation surface layer. Accordingly, when a chip is mounted to such wiring boards, the electric insulation surface layer minimizes or eliminates the connection between adjacent solder bumps during re-fusing of the solder. | 07-26-2012 |
20120186863 | MULTILAYER WIRING BOARD - A multilayer wiring board including a build-up layer comprising a conductor layer and a resin insulation layer that are alternately layered, conductive pads formed on a surface of a resin insulation layer so as to project from the surface, and a solder layer formed over an upper surface of each of the conductive pads is provided. The upper surface of the conductive pads may have a recess, and the entire surface of the solder layer may be situated at an elevated position with respect to an outer periphery portion of the upper surface. Embodiments make it possible to feed and hold a sufficient amount of solder paste on the upper surface of conductive pads, thereby minimizing or eliminating the occurrence of defective connections to a semiconductor element and damage to the solder layer caused by an insufficient thickness of the solder layer. | 07-26-2012 |
20120186864 | WIRING BOARD AND METHOD FOR MANUFACTURING THE SAME - A wiring board and a method for manufacturing the wiring board reinforced by means of a resin is provided. Embodiments of the wiring board allow for reliable attachment of a connection member, like a socket, to a terminal member. For example, a base of terminal pins is put on pin grid array (PGA) terminal pads, and a bonding material paste including solder and an electric insulation material made of a resin is placed on each of the PGA terminal pads. The bonding material paste is then heated to fuse the solder and soften the electric insulation material. Subsequently, the bonding material paste is cooled to solidify the solder and bond each of the bases to a corresponding PGA terminal pad and form an electric insulation surface layer on an exposed surface of each of solder junctions to which the respective bases are bonded. | 07-26-2012 |
20120211271 | MULTILAYER WIRING BOARD - A multilayer wiring board including a build-up layer, formed from one or more conductor and resin insulation layers that are layered one on top of the other, having conductive pads formed on a surface of at least one resin insulation layer so as to project from the surface are provided. The conductive pads may each include a columnar portion situated at a lower part thereof and a convex portion situated at a higher part thereof, wherein a surface of the convex portion may assume a continual curved shape. A solder layer may be formed over an upper surface of the conductive pads. Certain embodiments make it possible to minimize or eliminate the concentration of stress on the conductive pads, and may inhibit the occurrence of defective connections to a semiconductor element and infliction of damage to the conductive pads. | 08-23-2012 |
20130098670 | WIRING SUBSTRATE AND MANUFACTURING METHOD OF THE SAME - Embodiments of the present invention provide a wiring substrate that includes a structure where a plurality of projection electrodes are arranged within an electrode formation region on a substrate main surface. At least one among the plurality of projection electrodes has a larger outer diameter than an outer diameter of a via conductor and is a variant projection electrode which has a roughened upper surface. Embodiments of the present invention also provide methods for manufacturing wiring substrates having one or more of said variant projection electrode. | 04-25-2013 |
20130100626 | WIRING SUBSTRATE AND MANUFACTURING METHOD OF THE SAME - Embodiments of the present invention provide a wiring substrate having a structure where a plurality of projection electrodes are arranged within an electrode formation region on a substrate main surface. At least one among a plurality of the projection electrodes is a variant projection electrode which has a recess portion on an upper surface, an outer diameter at the upper end that is larger than an outer diameter at the lower end, and a reverse trapezoidal cross-section shape. Embodiments of the present invention also provide methods for manufacturing wiring substrates having one or more of said variant projection electrode. | 04-25-2013 |
20130111746 | METHOD OF MANUFACTURING MULTILAYER WIRING SUBSTRATE - A method of manufacturing a multilayer wiring substrate includes: a first laminate structure formation step of forming a first laminate structure on a support substrate, the first laminate structure including at least one conductor layer and at least one resin insulation layer; a core substrate formation step of laminating a core substrate on the first laminate structure such that a lower main surface of the core substrate comes in contact with the first laminate structure, the core substrate having a metal layer provided on an upper main surface thereof; and a second laminate structure formation step of forming a second laminate structure on the core substrate such that the second laminate structure covers the metal layer, the second laminate structure including at least one conductor layer and at least one resin insulation layer. | 05-09-2013 |
20130160290 | METHOD OF MANUFACTURING MULTI-LAYER WIRING BOARD - Embodiments of the presently-disclosed subject matter include a first laminated structure in which at least one conductor layer and at least one resin insulating layer are alternately formed is formed on a supporting substrate, and a core substrate is formed so as to come into contact with the conductor layer which is the uppermost layer of the first laminated structure. Then, laser light is emitted to the core substrate to form a through hole and a metal layer is formed in the through hole. Then, a second laminated structure including at least one conductor layer and at least one resin insulating layer is formed on the core substrate. At that time, the thickness of the conductor layer which is the uppermost layer of the first laminated structure is greater than that of the other conductor layers. | 06-27-2013 |
20130161079 | MULTI-LAYER WIRING SUBSTRATE AND MANUFACTURING METHOD THEREOF - Embodiments of the presently-disclosed subject matter include a multilayer wiring substrate including a first laminated structure that includes at least one conductive layer and at least one resin insulating layer; a core substrate that includes a reinforced fiber and that is laminated on the first laminated structure; and a second laminated structure that includes at least one conductive layer and at least one resin insulating layer and that is formed on the core substrate; and a plurality of via conductors which penetrate the first laminated structure, the core substrate, and the second laminated structure in the thickness direction, wherein the plurality of via conductors all expand in diameter in one direction, and the reinforced fiber is located above a center of the core substrate in the thickness direction. | 06-27-2013 |
20130180772 | WIRING BOARD AND METHOD OF MANUFACTURING THE SAME - Embodiments provide a wiring board which is structured to be suitable for connection with components, whereby its reliability can be improved. An embodied wiring board of the invention has pads and a solder resist in which opening portions which expose the pads are formed. Protrusion-shaped members are fixed to some of the surfaces of the pads. The surfaces of the pads and the surfaces of the protrusion-shaped members are covered with solder bumps. The height of the solder bumps is larger than the height H | 07-18-2013 |
20140202740 | Method of Manufacturing Multilayer Wiring Substrate, and Multilayer Wiring Substrate - In a build-up step, a plurality of resin insulation layers and a plurality of conductive layers are alternately laminated in multilayer arrangement on a metal foil separably laminated on a side of a base material, thereby forming a wiring laminate portion. In a drilling step, a plurality of openings are formed in an outermost resin insulation layer through laser drilling so as to expose connection terminals. Subsequently, in a desmear step, smears from inside the openings are removed. In a base-material removing step performed after the build-up step, the base material is removed and the metal foil is exposed. | 07-24-2014 |
Patent application number | Description | Published |
20090277744 | LOCKING DEVICE OF ROTARY SHAFT - A locking device of a rotary shaft includes a clutch member rotating integrally with the rotary shaft and provided so as to be displaceable in the direction of axis of the rotary shaft, a locking member provided in a fixed state to engage the clutch member to regulate the rotation of the clutch member, a biasing member biasing the clutch member toward the locking member, and a torque transmission member rotating under the rotary torque transmitted thereto from a power source, having a boss loosely inserted into a cam groove provided in an outer peripheral portion of the clutch member, and transmitting the rotary torque to the clutch member via the boss. The boss is displaced within the cam groove with switching of the rotation/stop of the torque transmission member or switching of the rotational direction thereof. | 11-12-2009 |
20090279933 | ROTARY SHAFT LOCKING DEVICE AND RECORDING APPARATUS HAVING THE SAME - A rotary shaft locking device includes a locking unit having a transmission gear receiving rotary torque from a power source, transmitting rotary torque to a rotary shaft as the transmission gear receives rotary torque from the power source, and locking the rotary shaft as transmission of rotary torque from the power source is cut off, and a first planetary gear and a second planetary gear provided to be meshed with a sun gear and to planetarily move around the sun gear, and displaced between a meshed position and an unmeshed position so as to be meshed with and separated from the transmission gear. The locking unit locks the rotary shaft for a power cutoff time which occurs when the rotation direction of the sun gear is switched and for which the transmission gear is not meshed with both the first planetary gear and the second planetary gear. | 11-12-2009 |
20120195669 | RECORDING DEVICE - A sheet cassette includes a lower stage side tray that accommodates a sheet, an upper stage side tray that is slidable with respect to the lower stage side tray on an upper portion of the lower stage side tray and accommodates the sheet, and a discharged sheet tray that is slidable with respect to the upper stage side tray, is displaceable to a position to receive the sheet discharged after being recorded on, and covers an upper portion of the upper stage side tray. The upper stage side tray and the discharged sheet tray are configured to be driven by a driving unit, and the discharged sheet tray is displaced by the driving unit to a position to receive the sheet. | 08-02-2012 |
20130257960 | RECORDING APPARATUS - A discharged sheet reception tray is displaced between a most protruded position which protrudes most and an accommodation position which is accommodated inside an apparatus. Since a control unit switches the positions of the discharged sheet reception tray depending on a length of a sheet to be discharged, taking the sheet from the discharged sheet reception tray is easily improved. Specifically, since a drive unit driving the discharged sheet reception tray is controlled so that a leading edge of the discharged sheet protrudes by a predetermined amount from the discharged sheet reception tray, it is possible to easily take the sheet from the discharged sheet reception tray by picking up the leading edge of the sheet. | 10-03-2013 |
20130258416 | RECORDING APPARATUS - A recording apparatus includes a recording unit that performs a recording operation on a medium, a discharge unit that discharges the medium that has undergone the recording operation by the recording unit, a medium receiving tray that receives the medium discharged from the discharge unit, the medium receiving tray being shiftable between a first state in which the medium receiving tray is drawn out in a medium discharge direction and a second state in which the medium receiving tray is retracted in a direction opposite to the medium discharge direction, and a blocking mechanism configured to be engaged with the trailing edge of the medium while the medium receiving tray is shifted from the first state to the second state, and to restrict the medium from being drawn inside. | 10-03-2013 |
20150294195 | RECORDING APPARATUS - A recording apparatus includes a recording head that performs recording on a medium, a carriage that reciprocates in a predetermined direction, and an operation panel that has a predetermined operation function. The carriage and the operation panel are adjacent to each other. The operation panel overlaps at least a portion of the carriage in a height direction of the recording apparatus. | 10-15-2015 |
Patent application number | Description | Published |
20130084580 | CHROMATOGRAPHIC KIT AND CHROMATOGRAPHY METHOD - A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance. | 04-04-2013 |
20140087367 | CHROMATOGRAPHY METHOD AND CHROMATOGRAPHIC KIT - The chromatography method includes a step of forming a composite with a test substance and a labeling substance containing a metal modified by a first binding substance of the test substance and then developing the composite on an insoluble carrier; a step of capturing the test substance and the labeling substance in a detection site on the insoluble carrier including a second binding substance of the test substance or a substance having a binding property to the first binding substance of the test substance; and a step of amplifying the captured labeling substance using a first amplification reagent and a second amplification reagent to detect the test substance. | 03-27-2014 |
20140093868 | CHROMATOGRAPHY METHOD - A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance. | 04-03-2014 |
20140242572 | CHROMATOGRAPHY METHOD, CHROMATOGRAPHY KIT, AND METHOD OF PRODUCING AN INSOLUBLE CARRIER FOR CHROMATOGRAPHY - A chromatography method including a step of developing a complex of a specimen and a labeled substance modified by a first bondable substance which can be bonded to the specimen on an insoluble carrier, a step of capturing the complex of the specimen and the labeled substance at a reactive site on the insoluble carrier, a step of washing the reactive site on the insoluble carrier using a washing liquid, a step of detecting the specimen which is captured at the reactive site after a signal of the labeled substance is amplified by an amplification liquid, in which the reactive site on the insoluble carrier includes (i) a second bondable substance which can be bonded to the specimen or a substance having affinity to the first bondable substance which can be bonded to the specimen, and (ii) polyethylene glycol having the molecular weight from 1,500 to 10,000. | 08-28-2014 |
20140295405 | CHROMATOGRAPHY METHOD, AND CHROMATOGRAPHY KIT - The chromatography method of the present invention includes (a) developing a complex of a test substance and a labeling substance modified with a first binding substance bindable to the test substance, onto an insoluble carrier, (b) causing the complex to be trapped in a reaction site on the insoluble carrier which contains a second binding substance bindable to the test substance or a substance exhibiting binding properties to the first binding substance, (c) washing the insoluble carrier with a washing solution containing at least one of the potassium iodide, urea, and guanidine after the step (b), (d) washing off the washing solution of the step (c) remaining in the insoluble carrier from the insoluble carrier, and (e) amplifying the labeling substance of the complex trapped in the reaction site. | 10-02-2014 |
Patent application number | Description | Published |
20130108306 | HEATER AND IMAGE HEATING APPARATUS INCLUDING THE HEATER | 05-02-2013 |
20130336672 | CONNECTOR FOR HEATER, FIXING APPARATUS AND IMAGE FORMING APPARATUS - An image fixing apparatus includes a heater including a substrate, a first electrode provided on one side of the substrate and a second electrode provided on the other side of the substrate; and a connector, connected with the heater, for receiving electric power, the connector including an electrically insulative housing, and a contact terminal provided inside the housing and having first spring contact contacted to the first electrode and a second spring contact contacted to the second electrode, wherein the first spring contact and the second spring contact are disposed at positions different as seen in a direction perpendicular to a surface of the substrate. | 12-19-2013 |
20140308049 | IMAGE FORMING APPARATUS HAVING TWO OR MORE LIGHT RECEIVING UNITS - An image forming apparatus includes an image carrier, an image forming means for forming a patch image on the image carrier, a light emitting means, a plurality of light receiving means adjacently arranged so as to receive light reflected from the patch image when light is irradiated by the light emitting means onto the patch image which moves with movement of the image carrier and each including one or more light receiving elements, and an output means for outputting an output signal that depends on a difference between a received light quantity of a first light receiving means and a received light quantity of a second light receiving means that are respectively odd-numbered and even-numbered in the arrangement order of the light receiving means. | 10-16-2014 |
20150023065 | VOLTAGE GENERATING APPARATUS AND IMAGE FORMING APPARATUS INCLUDING THE SAME - Until an output voltage of a converter reaches a threshold value, a control part performs switching control, and after the output voltage reaches the threshold value, the control part performs supply voltage control while the state of a switching control signal at the time when the output voltage reaches the threshold value is maintained. Switching control is a control method in which the output voltage is adjusted by adjusting the frequency or duty ratio of the switching control signal that drives a driving part. Supply voltage control is a control method in which the output voltage is adjusted by adjusting the supply voltage that is applied to the primary side of the converter. | 01-22-2015 |
20150063855 | VOLTAGE GENERATING APPARATUS FOR STABLY CONTROLLING VOLTAGE - A negative bias circuit outputs a DC voltage of a negative polarity. A positive bias circuit outputs a DC voltage of a positive polarity. The DC voltage of the positive polarity is used, for example, as a transfer voltage, and the DC voltage of the negative polarity is used as a cleaning voltage for cleaning toner. A cycle of the clock signal in a period during which the DC voltage of the first polarity is output is longer than a cycle of the clock signal in the period during which the voltage supplied to the load transits from the DC voltage of the first polarity to the DC voltage of the first polarity. | 03-05-2015 |
20150139672 | IMAGE FORMING APPARATUS - An image forming apparatus includes a fixing portion for heating and fixing an unfixed image formed on a recording material, the fixing portion including a cylindrical film, a heater provided in a cylindrical shape of the film, a switch portion actuatable by heat from the heater, and a protection element for shutting off electric power supplied to the heater; a DC voltage source for generating a DC voltage from commercial AC voltage source, wherein the protection element is disposed in the shape of cylinder of the film is connected in a DC circuit operable by the DC voltage source, and wherein when the switch portion is rendered off, the electric power supply to the heater is shut off. | 05-21-2015 |
20150139681 | CONNECTOR FOR HEATER, FIXING APPARATUS AND IMAGE FORMING APPARATUS - An image fixing apparatus includes a heater including a substrate, a first electrode provided on one side of the substrate and a second electrode provided on the other side of the substrate; and a connector, connected with the heater, for receiving electric power, the connector including an electrically insulative housing, and a contact terminal provided inside the housing and having first spring contact contacted to the first electrode and a second spring contact contacted to the second electrode, wherein the first spring contact and the second spring contact are disposed at positions different as seen in a direction perpendicular to a surface of the substrate. | 05-21-2015 |
20150268608 | HEATER AND IMAGE HEATING APPARATUS INCLUDING THE HEATER - The image heating apparatus includes an endless belt, a connector and a heater including an insulated substrate, a heat generating resistor, an electrode brought into contact with a contact of the connector; and a conductor provided on a surface of the insulated substrate opposite to a surface on which the electrode wherein the insulated substrate includes multiple through holes electrically connecting the electrode and the conductor to each other, in an area in which the electrode is provided, wherein the distances between a position on the electrode brought into contact with the contact and the multiple through holes are substantially equal to each other, so that burning of the through hole and conduction failure caused by the burning can be prevented. | 09-24-2015 |
20150338795 | IMAGE HEATING DEVICE - An image heating device is provided with a tubular film, and a unit placed inside the film. The unit includes a heater in contact with an inner surface of the film, a supporting member supporting the heater, and a highly thermal conductive member. The highly thermal conductive member placed between the heater and the supporting member and in contact with the heater. The unit is configured such that when the unit is viewed from a side where a surface of the heater is in contact with the film, at least a portion of the highly thermal conductive member is visible without being hidden behind the heater. | 11-26-2015 |
20150338804 | IMAGE HEATING APPARATUS - An image heating apparatus includes a heater including a substrate and a heat generating element provided on the substrate; a supporting member supporting the heater, the supporting member being provided with a recess for receiving the heater; a high heat conduction member having a thermal conductivity at least in a direction parallel with a surface higher than a thermal conductivity of the substrate, the high heat conduction member being sandwiched between the heater and the supporting member. A side surface of the heater and a surface, defining the recess and opposing the side surface of the heater, of the supporting member are bonded by adhesive material with each other to fix the heater and the supporting member to each other. | 11-26-2015 |