Assaraf
Jonathan David Assaraf, New York, NY US
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20150251819 | CLOSURE ASSEMBLY INCLUDING PIVOTABLE HANDLE AND METHOD FOR SEALING A CONTAINER - A closure assembly includes a cap having a radially outer wall surrounding a central axis and a handle having a first end portion and a second end portion. The cap also includes a threaded portion configured for threaded engagement with the container. The handle is pivotably coupled to the cap proximate the first end portion whereby the handle is configured to be movable between a stowed first position and a deployed second position relative to the cap. In the second position, the second end portion of the handle is positioned radially outward of the outer wall such that the handle is accessible for rotation in opposite directions about the central axis to loosen or tighten the cap relative to the container. The cap, when tightened relative to the container, maintains sealing of the opening during movement of the handle between the first position and the second position. | 09-10-2015 |
20150251887 | CLOSURE ASSEMBLY INCLUDING REMOVABLE WRENCH AND METHOD FOR SEALING A CONTAINER - A closure assembly includes a cap including a radially outer lip, a radially inner projection, and a groove located therebetween, and a threaded portion configured for threaded engagement with a container. The assembly also includes a wrench including a handle and a gripping portion. At least part of the gripping portion is configured to extend into the groove in an assembled position with the gripping portion engaging the outer lip and the inner projection such that rotation of the wrench in opposite directions results in the cap being loosened or tightened relative to the container. The wrench may also be used to hold the cap when the cap is removed from the container. | 09-10-2015 |
Meneachem Assaraf, Lehavim IL
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20100291230 | Novel Pesticide Compositions - Novel pesticide compositions and formulations, containing a phosphorous-containing compound and a nitrogen-releasing compound, are disclosed. These novel compositions exhibit a synergistic pesticidal activity and are particularly useful in treating pests such as nematodes (including root-not nematodes), fungi and bacteria. Methods utilizing these compositions for controlling pests, articles-of-manufacture containing same and processes of preparing same are further disclosed. | 11-18-2010 |
Yehuda Assaraf, D. N Misgav IL
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20090298055 | PRODUCTION OF PROTEINS - The present invention is of a method of producing proteins in mammalian cells using a permanent selection in the absence of cytotoxic drugs. Specifically, the present invention can be used to produce large quantities of highly pure human proteins which are suitable for pharmaceutical applications. | 12-03-2009 |
Yehuda G Assaraf, Moshav Rakefet - Doar-Na Misgav IL
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20110229892 | METHOD FOR PREDICTING A PATIENT'S RESPONSIVENESS TO ANTI-FOLATE THERAPY - A method of predicting responsiveness of a subject to a folylpolyglutamate synthetase (FPGS) dependent anti-folate is provided. The method comprises analyzing for a presence or absence of a splice variant of FPGS or a polypeptide encoded thereby, in a sample of the subject, wherein the presence of the splice variant or the polypeptide encoded thereby is indicative of a negative response to a FPGS-dependent anti-folate. Kits for prediction responsiveness of a subject to FPGS-dependent anti-folate are also disclosed. Antibodies specific for splice variants, the splice variant nucleic acids and polypeptides encoded by the splice variants are also claimed. In particular splice variants missing exons selected from the group of exon 3, exon 7, exon 10 and exon 12 are disclosed. | 09-22-2011 |
Yehuda G. Assaraf, Doar-Na Misgav IL
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20100137351 | Imidazoacridinone derivative compounds and methods for their use - The present invention provides IA derivative compounds of the formula: | 06-03-2010 |
Yehuda G. Assaraf, Misgav IL
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20110045092 | CASEIN PARTICLES ENCAPSULATING THERAPEUTICALLY ACTIVE AGENTS AND USES THEREOF - Casein particles, such as micelles or clusters thereof, having encapsulated therein hydrophobic and/or water insoluble therapeutically active agents such as hydrophobic chemotherapeutic agents, which are otherwise administered parenterally, are disclosed. Pharmaceutical compositions containing the casein particles and uses thereof in the treatment of cancer and other conditions treatable by the encapsulated therapeutically active agent are also disclosed. Further disclosed are processes of preparing the casein particles. The disclosed casein particles are useful for orally delivering the therapeutically active encapsulate and can further be used for controllably releasing the agents in the gastrointestinal tract. | 02-24-2011 |
Yehuda G. Assaraf, Moshav Rakefet IL
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20120283620 | TREATMENT UTILIZING HYDROPHOBIC WEAK BASES CHEMOTHERAPEUTIC AGENTS AND ILLUMINATION - Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination. | 11-08-2012 |
20140113927 | TREATMENT UTILIZING HYDROPHOBIC WEAK BASES CHEMOTHERAPEUTIC AGENTS AND ILLUMINATION - Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination. | 04-24-2014 |
Yehuda G. Assaraf, D.n. Misgav IL
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20100330572 | ORGANIC COMPOUNDS - The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. | 12-30-2010 |
20120276579 | ORGANIC COMPOUNDS - The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. | 11-01-2012 |
20140295489 | ORGANIC COMPOUNDS - The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. | 10-02-2014 |