Patent application number | Description | Published |
20150298220 | ROTATING TOOL, IN PARTICULAR DRILL, AS WELL AS A METHOD FOR MANUFACTURING A ROTATING TOOL OF THIS TYPE - The rotating tool, in particular a drill, includes a fluted cutting shank made of a resistant material, in particular carbide, extending in an axial direction along a rotational axis. Connecting to the cutting shank in the axial direction is an intermediate shank made of a material of greater elasticity in comparison the resistant material, in particular of tool steel. The intermediate shank includes an insertable cutting insert that may be exchanged. The cutting shank is preferably a cutting shank recycled from a used solid carbide drill. | 10-22-2015 |
20150298221 | MACHINING TOOL AND METHOD FOR MANUFACTURING A MACHINING TOOL - A machining tool, in the area of a tool tip, includes an integrated cooling structure for transporting a coolant. The cooling structure is optionally or in combination designed as a porous structure or at least one cooling channel having a bent reversing segment, so that two channel segments are oriented in opposite directions. The cooling structure is integrated into a base body of a carrier tool. According to a method of the invention, the cooling structure is manufactured by means of a 3D printing method. | 10-22-2015 |
20150298222 | MACHINING TOOL AND METHOD FOR MANUFACTURING A MACHINING TOOL - A machining tool, in particular a drill carrier tool, includes a monolithic base body extending in the axial direction which, at least in one section, has a porous or grid-like core structure that is encased in a solid outer jacket. These measures allow less material to be used, while maintaining good mechanical properties. The porous or grid-like core structure is simultaneously used for transporting coolant. The base body is manufactured in particular by means of a 3D printing method. | 10-22-2015 |
Patent application number | Description | Published |
20080282512 | Belt End Connection For Fastening the End of a Supporting Belt in an Elevator System and Method For Fasteining the End of a Supporting Belt in an Elevator System - A belt end connection and method for fastening a belt end in an elevator installation includes a housing having a wedge pocket for holding the support belt end and a wedge. At least one wedge pocket surface facing the wedge is provided with a roughness that is different from a roughness of another surface of the wedge pocket. Advantageously, a wedge pocket adhesion surface lying closer to a loose run of the support belt is provided with a roughness greater than the roughness of the another surface, or a wedge pocket slide surface lying closer to a supporting run of the support belt is provided with a roughness less than the roughness of the another surface. | 11-20-2008 |
20090001333 | ELEVATOR ELEMENT FOR DRIVING OR REVERSING AN ELEVATOR SUSPENSION MEANS IN AN ELEVATOR SYSTEM - In an elevator element for driving or reversing an elevator suspension device in an elevator system, that interacts with an elevator suspension device, the arithmetic mean of the roughness value of the contact surface measured in the circumferential direction of the elevator element, and the mean roughness value of the contact surface measured in the axial direction of the elevator element, are different. The arithmetic mean roughness value of the contact surface measured in the circumferential direction of the elevator element is less than 1 micrometer. | 01-01-2009 |
20090127032 | BELT END CONNECTION FOR FASTENING A BELT END IN AN ELEVATOR INSTALLATION, AND METHOD FOR PROTECTING AND CHECKING A BELT END CONNECTION IN AN ELEVATOR INSTALLATION - A belt end connection for fastening a support belt end in an elevator installation and a method for protecting and checking a belt end connection in an elevator installation includes a twisting prevention device that prevents twisting of the belt end connection about the longitudinal axis thereof. A wedge retains the support belt end in a wedge pocket and is secured by a loss prevention device against slipping out of the wedge pocket. The twisting prevention device and/or the loss prevention enable efficient protection of the support belt and/or of the belt end connection against damage and make possible efficient checking and control of the belt end connection. | 05-21-2009 |
20090166132 | Elevator System Having a Flat Belt with Wedge-Shaped Ribs - An elevator installation is provided that includes an elevator cage, a drive pulley, at least one support means formed as a flat belt, and a drive engine which drives the at least one support means, which carries the elevator cage, by way of the drive pulley. In the elevator installation, the support means has, at least on a running surface facing the drive pulley, several ribs of wedge-shaped or trapezium-shaped cross-section which extend parallel in a longitudinal direction of the support means and further has several tensile carriers oriented in the longitudinal direction of the support means. The tensile carriers are sized so that a total cross-sectional area of all the tensile carriers amounts to 30%-40% of a cross-sectional area of the support means. The tensile carriers may be distributed in a transverse direction of the support means so that exactly two tensile carriers are associated with each of the ribs, the tensile carriers having an outer diameter equal to 35%-40% of a rib spacing (T). | 07-02-2009 |
20100133046 | ELEVATOR SYSTEM, SUSPENSION ELEMENT FOR AN ELEVATOR SYSTEM, AND DEVICE FOR MANUFACTURING A SUSPENSION ELEMENT - An elevator system with a car or platform to transport passengers and/or goods as well as with a counterweight, which are arranged as traversable or movable along a travel path, and which are coupled and/or with a drive by a suspension element interrelating their motion. The suspension element is guided and/or driven by a traction sheave and/or a drive shaft and/or a deflecting pulley. The suspension element is sheathed and/or belt-type, with a first layer made of a first plasticizable and/or elastomeric material, containing a first exterior surface, and with at least one tension member—rope-type, tissue-type, or comprising a multitude of partial elements—that is embedded in the first layer of the suspension element. A manufacturing procedure for one of the suspension elements is provided. | 06-03-2010 |
20100140022 | ELEVATOR BELT, METHOD FOR PRODUCING SUCH AN ELEVATOR BELT, AND ELEVATOR SYSTEM HAVING SUCH A BELT - An elevator belt comprising a belt body made of a first material, a reinforcement arrangement having at least one reinforcement provided on the belt body, and a tube arrangement made of a second material having at least one tube, the at least one reinforcement of the reinforcement arrangement being provided in a tube of the tube arrangement. | 06-10-2010 |
20110088981 | METHOD AND DEVICE FOR PRODUCING A SUPPORT BELT FOR AN ELEVATOR INSTALLATION - A process for producing a support belt for an elevator system includes steps of: placing at least one cable-shaped tension support in position; embedding the tension support in a first belt layer made from a first plasticizable material to produce a partial belt having a first outer surface and a surface which forms a connecting plane, wherein parts of the tension support project out of the connecting plane and at least parts of the projecting portion of the tension support are covered by the first plasticizable material; and integrally forming a second belt layer made from a second plasticizable material on the connecting surface of the partial belt and the projecting portions of the tension support so as to produce a support belt having the first outer surface on the side of the first belt layer and a second outer surface on the side of the second belt layer. | 04-21-2011 |
20110272215 | ECCENTRICALLY SUSPENDED ELEVATOR CAR - An elevator system has at least one elevator car and at least one counterweight which are displaced in opposing directions along at least one guide track in an elevator shaft by a supporting and driving apparatus that is guided by a drive pulley of a drive. The supporting and driving apparatus is fastened directly to the elevator car eccentrically with respect to a center of gravity of the elevator car so that a tilting or load moment results thereby, wherein the tilting or load moment can be compensated by a compensation device. | 11-10-2011 |
20120211310 | ELEVATOR SYSTEM AND LOAD BEARING MEMBER FOR SUCH A SYSTEM - An elevator system has a suspension member for supporting and/or moving an elevator car and being guided and driven by a traction sheave of a drive unit. The suspension member is a cord or rope that includes a body made of a polymer and at least one tension member made of wires extending in the longitudinal direction of and embedded in the body. A thickest wire in the tension member has a bending stress σb in a range from 350 N/mm | 08-23-2012 |
20130048431 | ELEVATOR WITH COMPENSATING DEVICE - A compensating means is guided between an elevator cage and a counterweight on the counterweight side by a guide device and monitored by a monitoring device. | 02-28-2013 |
20140246274 | ECCENTRICALLY SUSPENDED ELEVATOR CAR - An elevator installation has at least one elevator car and at least one counterweight which are displaced in opposing directions along at least one guide track in an elevator shaft by a supporting and driving apparatus that is guided by a drive pulley of a drive. The supporting and driving apparatus is fastened directly to the elevator car eccentrically with respect to a center of gravity of the elevator car so that a tilting or load moment results thereby, wherein the tilting or load moment is compensated by a compensation device. | 09-04-2014 |
20150024891 | SUSPENSION ELEMENT FOR AN ELEVATOR SYSTEM - An elevator system includes a car or platform to transport passengers and/or goods as well as a counterweight, which are arranged as traversable or movable along a travel path, and which are coupled and/or with a drive by a suspension element interrelating their motion. The suspension element is guided and/or driven by a traction sheave and/or a drive shaft and/or a deflecting pulley. The suspension element is a sheathed and/or belt-type, with a first layer made of a first plasticizable and/or elastomeric material and a second layer with a connection plane formed between the first and second layers. At least one tension member—rope-type, tissue-type, or comprising a multitude of partial elements—is embedded in an area of the connection plane, a majority of a surface of said at least one tension member directly contacting said first layer. A manufacturing procedure for one of the suspension elements is provided. | 01-22-2015 |
Patent application number | Description | Published |
20090062138 | Array-based method for performing SNP analysis - An array-based method for performing SNP analysis is provided. In certain embodiments, the method may comprise: a) contacting a labeled genomic sample with an array comprising a first SNP-detecting oligonucleotide and a second SNP-detecting oligonucleotide that differ from each other by a single nucleotide, under hybridization conditions that provide binding equilibrium; and b) evaluating a SNP of said labeled genomic sample by comparing: i. binding of the labeled genomic sample to the first SNP-detecting oligonucleotide and ii. binding of the labeled genomic sample to said second SNP-detecting oligonucleotide. | 03-05-2009 |
20100081131 | IDENTIFICATION OF MICROBES USING OLIGONUCLEOTIDE BASED IN SITU HYBRIDIZATION - A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting a sample comprising a microbe with a set of at least two labeled oligonucleotides under in situ hybridization conditions to produce a contacted sample, where the labeled oligonucleotides i. hybridize to different RNA molecules of the microbe at sites that are unique to the microbe, ii. provide a predetermined optically detectable signature that identifies the microbe when the labeled oligonucleotides are hybridized to the different RNA molecules of the microbe, and iii. do not hybridize to ribosomal RNA of the microbe; b) reading the contacted sample to detect hybridization of the labeled oligonucleotides; and c) determining the identity of the microbe on the basis of the predetermined optically detectable signal, where the predetermined optically detectable signal indicates the identity of the microbe in the sample. | 04-01-2010 |
20100081576 | METHOD FOR GENOME ANALYSIS - A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting under primer extension conditions a genomic sample comprising a test genome with a set of at least ten sequence-specific primers that are complementary to sites in only one strand of a reference chromosomal region, to produce primer extension products, and b) analyzing the primer extension products to identify a chromosomal rearrangement in the test genome. | 04-01-2010 |
20100129879 | GENOME PARTITIONING USING A NICKING ENDONUCLEASE - A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-stranded genomic region with an oligonucleotide comprising: i. an affinity tag; and ii. a nucleotide sequence that is complementary to the nucleotide sequence that is immediately adjacent to the nick site, to produce a duplex in which a terminal nucleotide of the oligonucleotide lies immediately adjacent to said a nucleotide of the nick site; c) ligating the terminal nucleotide of the oligonucleotide to the nucleotide of the nick site to produce a ligation product; and d) separating the ligation product from unligated products using the affinity tag. Compositions and kits for practicing the method are provided. | 05-27-2010 |
20100137154 | GENOME ANALYSIS USING A METHYLTRANSFERASE - A method of genome analysis is provided. In certain embodiments, the method may comprise: labeling the test genome using a first site-specific methyltransferase to produce a labeled test genome comprising a label; and analyzing the labeled test genome to determine if the test genome comprises a sequence alteration relative to a reference sequence. In certain embodiments, the method may comprise: evaluating binding of the labeled test genome to an array of probes, or observing a pattern of labeling along the labeled test genome. | 06-03-2010 |
20100221708 | METHOD FOR CHROMOSOME ENUMERATION - A method of sample analysis is provided. The method comprises: a) contacting a genomic sample comprising a plurality of intact chromosomes, i.e., metaphase or interphase chromosomes, with a first set of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample comprising labeled chromosomes, where i. each of the labeled oligonucleotide probes is complementary to a non-repetitive, unique sequence in a region that flanks the centromere of a single chromosome of the plurality of chromosomes; and ii. hybridization of the labeled oligonucleotide probes to the chromosomes produces a distinct labeling pattern for each hybridized chromosome, thereby allowing each of the labeled chromosomes to be distinguished from one another; b) imaging the hybridized chromosomes to provide an image showing the labeling pattern for each labeled chromosome; and c) enumerating a labeled chromosome based on the labeling pattern of said labeled chromosome. A composition and kits for performing the method are also provided. | 09-02-2010 |
20120115237 | ISOLATION OF RNA-PROTEIN COMPLEXES USING CROSS-LINKING REAGENTS AND OLIGONUCLEOTIDES - Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product comprising cross-linked protein, and RNA; b) contacting the first cross-linked product and a second compound under conditions by which an oligonucleotide portion of the second compound hybridizes to the RNA; c) activating a reaction the first and second compound, thereby covalently crosslinking the oligonucleotide to the cross-linked protein to produce a second cross-linked product; d) isolating the second cross-linked product using an affinity tag; and e) analyzing the isolated second cross-linked product. Compounds for performing the method are also provided. | 05-10-2012 |
20120208707 | LIGATION METHOD EMPLOYING RTCB - A method of processing an RNA sample is provided. In certain embodiments, the method may comprise: a) obtaining a fragmented RNA sample comprising: i. RNA fragments of long RNA molecules; and ii. unfragmented short RNA; and b) contacting said fragmented RNA sample with a first adaptor in the presence of a RtcB ligase, thereby producing a ligated RNA sample comprising adaptor-ligated fragments of long RNA. A kit for performing the method is also provided. | 08-16-2012 |
20130123129 | USE OF DNAZYMES FOR ANALYSIS OF AN RNA SAMPLE - Provided herein is method comprising: contacting an initial RNA sample containing a population of different RNA molecules with a divalent cation and a set of DNAzymes that are designed to cleave multiple target RNAs in the initial sample, thereby producing a product RNA sample that comprises: a) uncleaved RNA molecules and b) cleaved RNA fragments that contain a 2′,3′-cyclic-phosphate and a 5′ hydroxyl as the result of DNAzyme cleavage. | 05-16-2013 |
20140356867 | NUCLEIC ACID ENRICHMENT USING CAS9 - A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA that is complementary to a site in the DNA, to produce a Cas9-fragment complex that comprises a fragment of the fragmented DNA; and (b) isolating the complex. In addition, other methods and compositions for Cas9/CRISPR-mediated nucleic acid manipulation are also provided. | 12-04-2014 |
20140357523 | METHOD FOR FRAGMENTING GENOMIC DNA USING CAS9 - A method for fragmenting a genome is provided. In certain embodiments, the method comprises: (a) combining a genomic sample containing genomic DNA with a plurality of Cas9-gRNA complexes, wherein the Cas9-gRNA complexes comprise a Cas9 protein and a set of at least 10 Cas9-associated guide RNAs that are complementary to different, pre-defined, sites in a genome, to produce a reaction mixture; and (b) incubating the reaction mixture to produce at least 5 fragments of the genomic DNA. Also provided is a composition comprising at least 100 Cas9-associated guide RNAs that are each complementary to a different, pre-defined, site in a genome. Kits for performing the method are also provided. In addition, other methods, compositions and kits for manipulating nucleic acids are also provided. | 12-04-2014 |
20150125862 | ISOLATION OF RNA-PROTEIN COMPLEXES USING CROSS-LINKING REAGENTS AND OLIGONUCLEOTIDES - Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product comprising cross-linked protein, and RNA; b) contacting the first cross-linked product and a second compound under conditions by which an oligonucleotide portion of the second compound hybridizes to the RNA; c) activating a reaction the first and second compound, thereby covalently crosslinking the oligonucleotide to the cross-linked protein to produce a second cross-linked product; d) isolating the second cross-linked product using an affinity tag; and e) analyzing the isolated second cross-linked product. Compounds for performing the method are also provided. | 05-07-2015 |
20150148239 | SPATIAL MOLECULAR BARCODING OF IN SITU NUCLEIC ACIDS - This disclosure provides, among other things, a method for analyzing a planar cellular sample. In some embodiments, the method comprises: (a) indirectly or directly attaching nucleic acid tags to binding sites in a planar cellular sample; (b) contacting the planar cellular sample with a solid support comprising an array of spatially addressed features that comprise oligonucleotides, wherein each oligonucleotide comprises a molecular barcode that identifies the feature in which the oligonucleotides is present; (c) hybridizing the nucleic acid tags, or a copy of the same, with the oligonucleotides to produce duplexes; and (d) extending the oligonucleotides in the duplexes to produce extension products that each comprises (i) a molecular barcode and (ii) a copy of a nucleic acid tag. Other embodiments, e.g., kits and the like, are also described. | 05-28-2015 |