45th week of 2015 patent applcation highlights part 25 |
Patent application number | Title | Published |
20150315490 | SYSTEMS AND METHODS FOR INCREASING DEASPHALTED OIL YIELD OR QUALITY - Systems and methods are provided for deasphalting with integrated hydrodynamic cavitation to improve the yield or quality of deasphalted oil obtained from a deasphalting unit. | 2015-11-05 |
20150315491 | METHODS AND SYSTEMS FOR IMPROVING PERFORMANCE OF DESALTING UNITS - New methods and systems for crude oil desalting are provided that utilize hydrodynamic cavitation to crack molecules that have a tendency to form emulsions, thereby allowing increased desalter throughput, reduced desalter operating temperatures, and/or reduced or eliminated need for diluent oil or emulsifier. | 2015-11-05 |
20150315492 | SYSTEMS AND METHODS FOR IMPROVING LIQUID PRODUCT YIELD OR QUALITY FROM DISTILLATION UNITS - Methods and systems are provided for improving liquid product quality or yield from atmospheric or vacuum distillation unit by subjecting fractionated streams from such distillation units to hydrodynamic cavitation. | 2015-11-05 |
20150315493 | PROCESS FOR THE PRODUCTION OF WHITE OILS MEETING THE CFR STANDARD FROM WASTE OILS - The present invention describes a process for the production of technical white oils or edible or medicinal oils from waste oils originating from industrial use or engine use, said process using a deep hydrotreatment. | 2015-11-05 |
20150315494 | METHODS AND SYSTEMS FOR IMPROVING THE PROPERTIES OF PRODUCTS OF A HEAVY FEED STEAM CRACKER - Methods and systems are provided for improving viscosity of a heavy hydrocarbon product stream such as a vapor-liquid separator drum bottoms stream, a steam cracker tar stream, or a combination thereof by subjecting the stream to cavitation to reduce the viscosity of the product stream. | 2015-11-05 |
20150315495 | SYSTEM AND METHODS OF TRIM DEWAXING DISTILLATE FUELS - Systems and methods are provided for dewaxing a distillate fuel oil by subjecting an at least partially hydroprocessed distillate fuel oil to cavitation to reduce the pour point, reduce the cloud point, reduce the cold filter plugging point, or a combination thereof of the distillate fuel oil. | 2015-11-05 |
20150315496 | Upgrading Hydrocarbon Pyrolysis Products - The invention relates to a utility fluid, such as a fluid containing aromatic and non-aromatic ringed molecules, useful as a diluent when hydroprocessing pyrolysis tar, such as steam cracker tar. The specified utility fluid comprises ≧10.0 wt % aromatic and non-aromatic ring compounds and each of the following: (a) ≧1.0 wt % of 1.0 ring class compounds; (b) ≧5.0 wt % of 1.5 ring class compounds; (c) ≧5.0 wt % of 2.0 ring class compounds; and (d) ≦0.1 wt % of 5.0 ring class compounds. The invention also relates to methods for producing such a utility fluid and to processes for hydroprocessing pyrolysis tar. | 2015-11-05 |
20150315497 | SYSTEMS AND METHODS OF INTEGRATED SEPARATION AND CONVERSION OF HYDROTREATED HEAVY OIL - Systems and methods are providing for integrating a cavitation unit to the backend separation system of a hydrotreater to improve conversion, | 2015-11-05 |
20150315498 | IMPROVED COAL GASIFICATION - A two-zone gasifier is used to produce syngas from coal fines, oxygen and steam. The two-zone gasifier has a top fluidized gasification zone and a bottom entrained flow gasification zone connected by a Venturi throat. The syngas production will occur in both zones with the syngas being collected from the top of the gasifier. | 2015-11-05 |
20150315499 | INTEGRATED TWO-STAGE THERMOCHEMICAL HEAT PIPE REACTOR HAVING A PARTITIONED VESSEL - A feedstock conversion system including an integrated two-stage fluid bed thermochemical reaction apparatus ( | 2015-11-05 |
20150315500 | METHOD OF AND APPARATUS FOR CONTROLLING A GASIFIER - A method of controlling a circulating fluidized bed gasifier includes feeding first and second portions of particulate material to be gasified through inlets in a gasifier. Oxygen and steam are fed through a bottom grid into a lower portion of the gasifier to fluidize the bed. Product gas and entrained particles are discharged from an upper portion of the gasifier. Particles are separated from the product gas and a portion of the separated particles is returned to the lower portion. A portion of the returned particles is oxidized to generate heat. Heat and oxidizing products from the lower portion are transferred to the center portion to generate the product gas. A ratio of the first and second portions of particulate material to be gasified is determined on the basis of a measured temperature profile so as to control the vertical temperature distribution in the gasifier. | 2015-11-05 |
20150315501 | SOLID GASIFICATION APPARATUS - A solid gasification apparatus includes a reaction chamber thermally insulated by a heat insulating material, a heat beam fluid heat exchange apparatus that produces a first heated gas and a second heated gas, and a unit that includes a gas flow path. The unit spays the first heated gas against a material solid in a reaction chamber to heat the material solid, and, simultaneously, makes the material solid react with the first heated gas to produce a produced gas containing the element of the material solid. The unit makes a second heated gas contact and react with the produced gas. | 2015-11-05 |
20150315502 | PROCESS FOR PRODUCING A FUEL AND BYPRODUCT FROM BIOMASS OR BIOMASS DERIVED MATERIAL - The present invention provides a process for producing a fuel and a byproduct from biomass or biomass derived material. The invention comprises providing a processed biomass feedstock and carrying out or causing one or more parties to subject the processed biomass feedstock to gasification to produce carbon monoxide and hydrogen and cresylic acid and recovering the cresylic acid or a portion thereof. The processed biomass feedstock may be co-gasified with coal. The hydrogen from the gasification may be recovered or the carbon monoxide and hydrogen may be further reacted to produce a fuel or fuel intermediate. One or more products obtained from the process are provided, for use as, or to produce a transportation or heating fuel. The invention may allow for advantaged fuel credit generation. | 2015-11-05 |
20150315503 | CYCLIC DIENE OR CYCLIC TRIENE-BASED DIESEL FUEL ADDITIVE - A fuel additive includes 50 wt. % to less than 75 wt. % cyclic dienes and/or cyclic trienes that thermally crack into only chain branching radicals and greater than 25 wt. % to 50 wt. % organo-nitrates and/or nitro-organics. The fuel additive is combined with fuel at a combined treat rate ranging from 1000 (wt.) ppm to 3000 (wt.)) ppm. | 2015-11-05 |
20150315504 | Arc-Produced Gas Mixed with other Gases - A system for producing a hybrid gas includes a pressure vessel containing in its interior a feedstock with at least one set of electrodes between which an electric arc is formed. The at least one set of electrodes is within the pressure vessel and submerged in the feedstock. A fluid system passes the feedstock through a plasma of the electric arc, thereby converting a portion of the feedstock into an arc-produced gas. The arc-produced gas is collected and mixed with at least one supplementary fluid to produce the hybrid gas. | 2015-11-05 |
20150315505 | BIOMASS SOLID FUEL - The present invention relates to a biomass solid fuel obtained by steam exploding and then molding biomass into biomass blocks and then heating the biomass blocks, wherein the biomass solid fuel has a fuel ratio of 0.2 to 2.5, a dry-based higher heating value of 5,000 to 7,500 (kcal/kg), a molar ratio of oxygen O to carbon C (O/C) of 0.1 to 0.6, and a molar ratio of hydrogen H to carbon C (H/C) of 0.5 to 1.35. | 2015-11-05 |
20150315506 | ADDITIVES FOR IMPROVING THE RESISTANCE TO WEAR AND LACQUERING OF VEHICLE FUELS OF THE GAS OIL OR BIO GAS OIL TYPE - The present disclosure relates to anti-lacquering additives for vehicle fuels of the gas oil or bio gas oil type having a sulphur content less than or equal to 500 ppm by mass. These additives also improve the lacquering resistance of the higher-grade vehicle fuels of gas oil or bio gas oil type having a sulphur content less than or equal to 500 ppm by mass. | 2015-11-05 |
20150315507 | FISCHER-TROPSCH DERIVED FUEL COMPOSITIONS - A fuel composition comprising a Fischer-Tropsch derived middle distillate fuel and a middle distillate flow improver, the remainder being another fuel component or mixture of fuel components. The other fuel component is selected from petroleum derived middle distillate fuel, hydrogenated vegetable oil, fatty acid methyl esters, and other Fischer Tropsch products. The Fischer-Tropsch derived middle distillate fuel is more than 80% v/v of the total composition; the maximum weight content in the carbon number distribution of the n-paraffins in the Fischer-Tropsch derived middle distillate fuel is below C16 and the weight ratio of iso to normal paraffins in the Fischer-Tropsch derived middle distillate fuel is 3.5:1 or higher. The middle distillate flow improver is a substituted ethylene polymer. | 2015-11-05 |
20150315508 | Disposable chimney charcoal starter, fuel package and method for starting a fire - The present invention provides a new means for kindling charcoal beginning from the center, thus it is possible to make a simple disposable chimney charcoal starter at low manufacturing costs. This disposable chimney charcoal starter includes a first chimney for containing loose discrete pieces of solid fuel, at least one ventilation opening on the first chimney, and a second chimney independent of the first chimney for deferring the burning off of the first chimney and for ventilation. The solid fuel could be prepackaged in the chimney charcoal starter to provide a fuel package. In the present invention, the solid fuel surrounding the second chimney serves as a heat insulator for the first chimney to allow sufficient time duration of “Chimney Effect” for all the solid fuel to be kindled before the first chimney is burnt off completely. | 2015-11-05 |
20150315509 | GREASE COPOSITIONS - A grease composition comprising base oil and as thickener calcium complex soap and lithium soap is disclosed. A higher fatty acid, an aromatic monocarboxylic acid and a lower fatty acid are used as carboxylic acids constituting the calcium complex soap and lithium soap. The grease composition has a high dropping point and excellent shear stability, and exhibits thermal stability and long bearing life. | 2015-11-05 |
20150315510 | PROCESS FOR PRODUCING AN OVERBASED METAL DETERGENT - A high TBN overbased metal sulfonate detergent is prepared by reacting a hydrocarbyl-substituted organic sulfonic acid or metal salt thereof with a basic alkali metal or alkaline earth metal compound in the presence of a mono-alcohol and a carboxylic acid and reacting this mixture with carbon dioxide to form a carbonated overbased metal sulfonate. The resulting overbased metal detergent has a metal equivalent to sulfonic acid substrate ratio of 5:1 to 27:1. The product thus prepared has improved viscometrics, filterability, and TBN:ash ratio. Lubricating compositions comprising said overbased detergent display reduced friction and wear performance. The invention further relates to methods of lubricating an internal combustion engine with a lubricant containing an overbased detergent prepared as described. | 2015-11-05 |
20150315511 | OIL SOLUBLE TAGGANTS - A process for detecting oil or lubricant contamination in the production of an article by adding a Stokes-shifting taggant to an oil or lubricant of a machine utilized to produce the article or a component thereof, irradiating the articles produced with a first wavelength of radiation, and monitoring the articles for emission of radiation at a second wavelength. The taggant can be in the form of a composition containing a Stokes-shifting taggant, which absorbs radiation at a first wavelength and emits radiation at a second wavelength, different from said first wavelength, dissolved or dispersed in an oil or lubricant. | 2015-11-05 |
20150315512 | WATER-BASED COOLANT - A water-based coolant contains: at least one inorganic acid salt selected from among carbonate, hydrogen carbonate, sesquicarbonate, phosphate, borate, molybdate and tungstate; and a metal corrosion inhibitor. The water-based coolant is excellent in cooling performance and unlikely to cause corrosion of a metal material to be cooled. Therefore, the water-based coolant is suitably usable as a quenchant or a cutting oil. | 2015-11-05 |
20150315513 | Aqueous Cutting Fluid Composition - A water-based cutting fluid that comprises water and a water-soluble polyalkylene glycol (PAG) having cloud point from 30° C. to 80° C. The cutting fluid is water-based, i.e., it comprises at least 50 percent by weight (wt %) water. The cutting fluids are well suited for use with diamond wiresaws for the cutting of silicon ingots. The fluids exhibit one or more of low hydrogen generation, no wafer cleaning issues, good lubricity, good cooling efficiency, good swarf suspension and dispersion, low foaming, are generally non-sensitive to metal ions, and are nonflammable. | 2015-11-05 |
20150315514 | A METHOD OF REDUCING FRICTION AND WEAR BETWEEN SURFACES UNDER A HIGH LOAD CONDITION - A method of using lubricant compositions to reduce wear between two surfaces exposed to a load condition of at least 1 GPa is provided. The lubricant compositions comprise polysiloxane base oils having alkylaryl or a combination of alkyl and aryl functionality. The polysiloxane base oils may be defined according to the formula: | 2015-11-05 |
20150315515 | UV CROSS-LINKING NEAT LUBRICANT MIXTURES FOR MAGNETIC RECORDING MEDIA - Disclosed herein is a lubricant for lubricating a surface of a magnetic recording medium. The lubricant is a substantially solvent free lubricant that includes a plurality of lubricant molecules. Each lubricant molecule includes a polymer chain that has a backbone section and at least one functional end group. Each lubricant molecule is exposed to a physical treatment to cross-link one of the backbone section of the polymer chain and the at least one functional end group with at least one other molecule. | 2015-11-05 |
20150315516 | ODORANTS OF THE VIOLET TYPE - The present invention relates to the use as perfuming ingredient, in particular to confer odor notes of the violet, violet leaves type, of a compound of formula (I), wherein n represents 1 or 2, A represents CH | 2015-11-05 |
20150315517 | CLEANING COMPOSITIONS EMPLOYING EXTENDED CHAIN ANIONIC SURFACTANTS - The invention discloses synergistic combinations of surfactants blends and cleaning composition. In certain embodiments a surfactant system is disclosed which includes extended anionic surfactants, linker surfactants, and a multiply charged cation component. This system forms emulsions with, and can remove greasy and oily stains, even those comprised of non-trans fats. The compositions may be used alone, as a pre-spotter or other pre-treatment or as a part of a soft surface or hard surface cleaning composition. | 2015-11-05 |
20150315518 | COLD WATER DETERGENT COMPOSITION AND METHOD - A cold water cleaning composition containing a peroxy compound, a chelating agent, a silicate, an acrylic polymer, an anionic surfactant, an amphoteric surfactant and an ionic surfactant in a basic composition using a water soluble metal hydroxide and a water soluble metal carbonate is provided. The base for the detergent is a water soluble metal alkali such as sodium, potassium or lithium hydroxide, and a metal carbonate such as sodium, potassium or lithium carbonate. | 2015-11-05 |
20150315519 | Cleaning Composition - A cleaning composition comprising a surfactant combination which comprises an amine oxide amphoteric surfactant; a first anionic surfactant comprising a poly(oxyalkylene) alkyl ether sulfate: and a second anionic surfactant comprising an alkyl ethoxy carboxylate. The combination provides increased foaming. | 2015-11-05 |
20150315520 | SOLVENT COMPOSITIONS - Provided herein are compositions comprising partially hydrogenated farnesene. In certain embodiments, the compositions are useful as solvents, degreasers, cleaning products, personal care products, and for other uses. Also provided herein are methods of making the compositions and methods of their use. | 2015-11-05 |
20150315521 | Esterquat Composition Having High Triesterquat Content - A composition comprising (a) an esterquat that is a quaternized reaction product of an alkanol amine and a fatty acid, wherein from at least 90 wt % to up to 100 wt % of the esterquat is comprised of triesterquat and from 0 wt % to up to 10 wt % of the esterquat is comprised of at least one of monoesterquat and diesterquat, and (b) a water swellable cationic polymer. The water swellable cationic polymer aids in dispersion and/or in deposition of the triesterquat. Also, a method of producing such a composition and a method of softening a fabric, and increasing fragrance delivery, comprising treating the fabric with the composition. | 2015-11-05 |
20150315522 | CLEANING COMPOSITION - A hard surface cleaning composition comprising:
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20150315523 | DETERGENT - An automatic dishwashing detergent composition comprising:
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20150315524 | CLEANING COMPOSITION CONTAINING A POLYETHERAMINE - A hard surface cleaning composition comprising:
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20150315525 | CLEANING COMPOSITION - A hard surface cleaning composition comprising:
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20150315526 | CLEANING COMPOSITION - A hard surface cleaning composition comprising:
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20150315527 | Polyurethane/Polyacrylic Hybrid Dispersions For Shine Applications In Home Care - A hard surface cleaning composition which provides a shine to hard surfaces and which is water resistant includes 0.001-50 wt. % of at least one detersive surfactant, at least 10 wt. % of a diluent, the diluent including water, and 0.01-40 wt. % of particles comprising at least one of an anionic polyurethane polymer and an anionic polyurethane hybrid polymer, formed as an aqueous dispersion, the particles having an average particle size of less than 170 nm. | 2015-11-05 |
20150315528 | DISPERSANT COPOLYMERS HAVING HIGH COMPATIBILITY WITH SURFACTANTS - A polymeric dispersant comprising: (a) from 50 to 95 wt % polymerized residues of monomer (A): | 2015-11-05 |
20150315529 | LOW-WATER TO WATER-FREE LIQUID CLEANING AGENT - The invention relates to liquid, low-water to water-free cleaning agents, in particular automatic dishwasher detergents, containing at least one rinse aid surfactant and at least one hydrophobically modified acrylate polymer or copolymer, selected from C | 2015-11-05 |
20150315530 | COMPOSITIONS AND METHODS FOR HANDLING POTENTIAL PRION CONTAMINATION - A composition and method of treatment for handling potential prion contamination of surfaces is disclosed. The products include and the treatment uses products that include at least one prion digester enzyme selected from a serine protease in solution with a non-ionic surfactant, a hydrotrope and high purity water | 2015-11-05 |
20150315531 | NON-FLAMMABLE TERNARY COMPOSITIONS AND USE OF THESE COMPOSITIONS - Non-flammable ternary compositions and use of these compositions. The invention relates to certain non-flammable compositions containing, 1,1,3,3-pentafluorobutane (R365mfc), 1,2-dichloroethylene and a hydrofluoroether, to mixtures containing these compositions and to the use of these non-flammable compositions or these mixtures, especially as precision cleaning agents for solid surfaces and for flushing, especially of refrigeration systems. | 2015-11-05 |
20150315532 | CONTAINER WITH CLOSURE DEVICE - A container has closure device ( | 2015-11-05 |
20150315533 | FERMENTATION OF JUICE - The present invention relates to a process of preparing a concentrated liquid foodstuff comprising treating a mixture of a juice concentrate having a Brix of from 5 to 20° Bx and a carbohydrate, with a yeast; to obtain a concentrated liquid foodstuff, wherein the alcohol content is lower than 15 g/kg of concentrated liquid foodstuff. | 2015-11-05 |
20150315534 | Enhanced Photobioreactor System - A space efficient photo-bioreactor. The bioreactor grows microalgae in a tall array of transparent flooded tubes. A nutrient media is circulated through the tubes. The array is configured to maximize the amount of sunlight falling upon each tube so that growth of the microalgae is as uniform as possible. A vertically-oriented gasser tube is provided. Gas is injected into this gasser tube along with the liquid nutrient medium. A bubble-size limiter is employed in the gas injector. The flow rates are configured so that the liquid nutrient medium and injected gas remain within the vertical gasser tube for 30 seconds or more. | 2015-11-05 |
20150315535 | Process for the Production of Biogas - A container ( | 2015-11-05 |
20150315536 | CELL CULTIVATING FLASK - A flask for the culturing of cells is disclosed. The cell culture chamber is defined by top and bottom walls connected by side and end walls, one end wall shaped such that media can drain to a bottommost spot thereby allowing for the complete removal of media via a vertically oriented pipette inserted into the interior of the flask body through an open neck. | 2015-11-05 |
20150315537 | CELL DETACHMENT DEVICE - A cell detachment device includes: a base; a vessel holder, to which a culture vessel is to be fitted; a guide mechanism configured to guide reciprocating movement of the vessel holder; a collided member configured to collide with the vessel holder when the vessel holder is moving; an urging member configured to urge the culture vessel toward the collided member; and a power imparting mechanism configured to impart, to the vessel holder, power for causing the vessel holder to move. | 2015-11-05 |
20150315538 | METHODS OF MICROALGAE CULTIVATION FOR INCREASED RESOURCE PRODUCTION - Methods of inducing or increasing lipid and protein production in microalgae are disclosed. Methods of enhancing microalgae biomass are also disclosed. The methods may comprise inoculating a culture media with microalgae and propagating the microalgae under heterotrophic growth conditions. The heterotrophic growth conditions may comprise inhibiting exposure of the inoculated culture media to light. The methods may further comprise delivering oxygen into the inoculated culture media. Additionally, lipids, proteins, and other cellular components may be isolated and purified from microalgae cultivated under the disclosed methods. | 2015-11-05 |
20150315539 | METHOD FOR STIMULATING CELL GROWTH - The invention provides a method for stimulating cell growth, differentiation and/or protein production in a cell. The method includes contacting a cell growth medium or fluid with a pulsed electromagnetic field (pEMF) and a low level laser (LLL). Contacting may be sequential or simultaneous. | 2015-11-05 |
20150315540 | Presaturation of Supercritical CO2 with Water for Decellularization of Matrices - Decellularization methods for tissue are provided. The method can include: exposing a tissue to a water-saturated, supercritical CO | 2015-11-05 |
20150315541 | MODIFIED POLYNUCLEOTIDES FOR ALTERING CELL PHENOTYPE - The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules. | 2015-11-05 |
20150315542 | METHOD FOR PRESERVING PROLIFERATION AND DIFFERENTIATION POTENTIAL OF UNDIFFRENTIATED CELLS - A method for preserving proliferation and differentiation potential of undifferentiated cells, has steps of providing a culture carrier having a surface coated with a biological material selected from the group consisting of hyaluronan, chondroitin sulfate, carboxymethyl cellulose, carrageenan, alginate, and chitosan; and inoculating and culturing the undifferentiated cells on the surface in the culture carrier with an appropriate medium, such that the proliferation and differentiation potential of undifferentiated cells are preserved. The method can be used for expanding stem cells in vitro without loss of their replicative ability and differentiation capacity. Therefore, the method according to the present invention is amenable to application in regenerative medicine, tissue engineering, and therapy using umbilical cord blood and other cell sources such as peripheral blood, stem cells, tissue progenitor cells, and tissue cells. | 2015-11-05 |
20150315543 | MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS - The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy. | 2015-11-05 |
20150315544 | BLOOD SEPARATION FILTER - A filter for separating blood components includes a first pleated wall having a collection end and a second pleated wall. The second pleated wall converges with the first pleated wall at the collection end. The first pleated wall and second pleated wall are both composed of a material that is porous and configured as a barrier to red blood cells. | 2015-11-05 |
20150315545 | Method of rapidly inducing large-scale and high-purity mesenchymal stem cells to transdetermine into hematopoietic stem cells - A method of rapidly inducing large-scale and high-purity mesenchymal stem cells to transdetermine into hematopoietic stem cells is provided with the steps of preparing homogeneous medium of mesenchymal stem cells; combining a plurality of small RNA molecules; assembling and transfecting nanoparticles of nucleic acids and polypeptides; inducing and amplifying medium of post-transdetermined hematopoietic stem cells; and activating a plurality of hemopoiesis-related genes. | 2015-11-05 |
20150315546 | ACCELERATED PREDICTION OF CANCER PROGRESSION AND RESPONSE TO TREATMENT - The present invention provides a method to rapidly screen tumor cells for invasive and metastatic characteristics, heterogeneity and their response to therapeutic agents, and provides a multi-well microinjection system for the automated imaging and microinjection of zebrafish embryos. | 2015-11-05 |
20150315547 | ONCOLYTIC ADENOVIRUSES WITH INCREASED PROPORTION OF THE 156R SPLICING ISOFORM OF THE E1B PROTEIN - The invention relates to a recombinant adenovirus that has an oncolytic effect in a cancer cell. By modulating the level and type of splice isoforms of the E1B gene product, expressed from the E | 2015-11-05 |
20150315548 | INFLUENZA VIRUS REASSORTMENT - New influenza donor strains for the production of reassortant influenza A viruses are provided. | 2015-11-05 |
20150315549 | BIOREACTOR COMPRISING IMMOBILIZED ENZYME, METHOD FOR IMPROVING ACTIVITY OF IMMOBILIZED ENZYME, AND BIOFUEL CELL - According to the present invention, the enzyme activity of an immobilized enzyme is improved regardless of enzyme type. A bioreactor, comprising an immobilized enzyme and a heterocyclic compound containing nitrogen and carbon atoms and having 5- or 6-membered ring, which form a reaction field, wherein the immobilized enzyme is allowed to cause an enzymatic reaction in the reaction field is, provided. | 2015-11-05 |
20150315550 | CAROTENE HYDROXYLASES AND THEIR USE FOR PRODUCING CAROTENOIDS - The present invention relates to novel hydroxylases, nucleic acid sequences coding therefore, expression constructs and vectors comprising these sequences, microorganisms transformed therewith, processes for the microbiological hydroxylation of isoprenoids, for example processes for converting beta-carotene into beta-cryptoxanthin and zeaxanthin, or canthaxanthin into astaxanthin. | 2015-11-05 |
20150315551 | Method for Modifying Carotenoid Biosynthesis in Plants - Methods are provided for modifying and screening for carotenoid biosynthesis in a plant. The methods are useful for enhancing plant adaptation to climate change and food security, providing increased carotenoid content to a plant, improving stress resistance to climate changes in a plant, and for selecting plants having improved stress resistance to climate changes | 2015-11-05 |
20150315552 | Inhibition of AXL Signaling in Primary Tumor Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6. | 2015-11-05 |
20150315553 | Modified AXL Peptides and Their Use in Inhibition of AXL Signaling in Anti-Metastatic Therapy - Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6. | 2015-11-05 |
20150315554 | CELL LINES EXPRESSING CFTR AND METHODS OF USING THEM - Disclosed herein are cells and cell lines that stably express CFTR and methods for using those cells and cell lines. The invention also includes techniques for creating these cells and cell lines. The cells and cell lines of this invention are physiologically relevant. They are highly sensitive and provide consistent and reliable results in cell-based assays. | 2015-11-05 |
20150315555 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 - Methods for developing non-peptidic inhibitors that target the polo-box domain of PLK1 proteins are described. Methods include developing structure activity relationships for peptidic inhibitors followed by development of non-peptide fragment alternatives for portions of the peptide inhibitors. The non-peptide fragment can provide similar structure activity relationship as the replaced peptide. Fragment alternatives to key binding determinants are identified in an iterative computational and synthetic process facilitated through understanding of the peptide structure-activity relationships. The approach is informed by peptide structure-activity data obtained through synthesis and testing of truncated and mutated analogs of known PBD binding motifs. | 2015-11-05 |
20150315556 | Fusion Molecules of Rationally-Designed DNA-Binding Proteins and Effector Domains - Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain. | 2015-11-05 |
20150315557 | MEGANUCLEASE VARIANTS CLEAVING THE GENOME OF A PATHOGENIC NON-INTEGRATING VIRUS AND USES THEREOF - An I-CreI variant, wherein at least one of the two I-Cre1 monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated from positions 26 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from the genome of a non-integrating virus, in particular herpes simplex virus (HSV) or Hepatitis B virus (HBV) for use in genome engineering and for in vivo and ex vivo (gene cell therapy) genome therapy as well as the treatment of a virus infection. | 2015-11-05 |
20150315558 | VARIANTS HAVING GLUCOAMYLASE ACTIVITY - The present invention relates to variants having glucoamylase activity with improved properties and to compositions comprising these variants suitable for use for example in the production of a food, beverage (e.g. beer), feed, biochemical, or biofuel. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process. | 2015-11-05 |
20150315559 | Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same - The present invention relates to polypeptides having cellulolytic enhancing activity, catalytic domains, and carbohydrate binding domains, and polynucleotides encoding the polypeptides, catalytic domains, and carbohydrate binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains, and carbohydrate binding domains. | 2015-11-05 |
20150315560 | VARIANTS OF CELLOBIOHYDROLASES - Disclosed are a number of homologs and variants of | 2015-11-05 |
20150315561 | Methods and Compositions for Modulating the Immune System with Arginase I - Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject. | 2015-11-05 |
20150315562 | Synthetically Functionalized Living Cells - Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs). | 2015-11-05 |
20150315563 | METHOD FOR ACTIVATION OF STEM CELL PROLIFERATION AND INCREASE OF STEM CELLS RESISTENCE TO NEGATIVE IMPACTS - Method for activation of stem cells' proliferation and increase in the resistance of the stem cells to negative impacts, without use of high-frequency electro-magnetic field, is provided. The technical result is achieved due to the treating of the cells culture with a weak low-frequency magnetic field. The proposed method includes: 1) Increase in number of the human stem cells in the culture after their exposure to a weak magnetic field over a representative for the given cell culture doubling half-period (for 24 hours, number of cells increases 2.5 times-at full doubling period of the intact cells equals to 48 hours); 2) Increase of amplitude of self-magnetic irradiation of the initial culture of the stem cells, which indicates increased activity. 3) Double increase in stability of the human stem cells with respect to the development of apoptosis and synchronization of the cells predominantly in G1 phase. | 2015-11-05 |
20150315564 | DEVICES AND KITS FOR COLLECTION, STORAGE AND ANALYSIS OF SAMPLES AND METHODS OF PRODUCTION AND USE THEREOF - Collection devices, kits and methods related to sample collection and analysis can be used to collect and store samples (e.g., biological samples) from a variety of sources and optionally, for analysis of such samples (e.g., forensics analysis, medical diagnostics, etc.). Methods of production and use thereof are described herein. A device for collecting a sample (e.g., a sample including nucleic acid) includes an outer protective housing and a collection tip operably coupled to a carrier. The collection tip includes a hydrophilic and at least partially soluble material (e.g., hydrophilic and at least partially soluble polycaprolactone (PCL)) and is movable (e.g., retractable) from a first protected position within the outer protective housing to a second collecting position outside the outer protective housing. | 2015-11-05 |
20150315565 | METHODS FOR IDENTIFYING AND ISOLATING CELLS EXPRESSING A POLYPEPTIDE - The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identifying, selecting, and isolating cells producing antigen-specific monoclonal antibodies. | 2015-11-05 |
20150315566 | METHOD FOR GENERATING HIGH AFFINITY, BIVALENT BINDING AGENTS - A combined Kunkel mutagenesis and phage-display method for producing bivalent binding agents is provided. | 2015-11-05 |
20150315567 | TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES - The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity. | 2015-11-05 |
20150315568 | Sieving Nucleic Acid Samples - A method of selecting nucleic acid samples including particular desired alleles from a plurality of nucleic acid samples including the steps of performing a first reaction in a plurality of pools containing the samples to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the desired alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products, and further identifying nucleic acid samples with the desired alleles. A source tag sharing number “d” may be determined for each of the alleles. Alleles may also be binned together. | 2015-11-05 |
20150315569 | METHOD FOR SCREENING A NUCLEIC ACID-PROGRAMMED SMALL MOLECULE LIBRARY - Provided herein is method of screening, comprising: a) combining a nucleic acid-programmed small molecule library with: an enzyme, and a substrate for the enzyme, wherein each of the members of the library comprises a test agent that is linked to an nucleic acid tag that encodes the test agent and the combining results in transferring a chemoselective functional group from the substrate onto at least some of the members of the library; b) isolating the library members onto which the chemoselective functional group has been covalently transferred; and c) amplifying the nucleic acid tags of the library members isolated in step b) to produce an amplification product. Libraries and kits for performing the method are also provided as are compounds and pharmaceutical compositions thereof. | 2015-11-05 |
20150315570 | DIRECTED EVOLUTION OF SYNTHETIC GENE CLUSTER - The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof. | 2015-11-05 |
20150315571 | Method of Nucleic Acid Fragmentation - A method of preparing an at least partially randomly sheared library of nucleic acids is provided. The method includes the steps of providing a source of nucleic acids, randomly incorporating modified bases into the nucleic acids, and digesting the modified nucleic acids with one or more modification-dependent restriction endonucleases to produce the nucleic acid library. The practice of the method can be facilitated using a kit for performing the method. The method can be used to form nucleic acid libraries and as part of a method of next generation sequencing. | 2015-11-05 |
20150315572 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 2015-11-05 |
20150315573 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION - Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function. | 2015-11-05 |
20150315574 | PRODUCTION OF STABLE NON-POLYADENYLATED RNAS - The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a 3′ terminal stabilizing triple helical structure. Related methods for expressing said RNAs in vivo and in vitro are also disclosed. | 2015-11-05 |
20150315575 | COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO CELL TYPES - The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a receptor which can be internalised by the cell in response to the binding of said selectivity agent. The conjugates of the present invention are useful for the delivery of the nucleic acid to cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes. | 2015-11-05 |
20150315576 | GENETIC DEVICE FOR THE CONTROLLED DESTRUCTION OF DNA - The invention relates to DNA destruction devices and related methods reagents and kits. The DNA destruction devices are useful for achieving target specific DNA destruction in vivo using a system that involves an actuator element and a CRISPR array, under specific regulatory control. | 2015-11-05 |
20150315577 | A METHOD FOR INHIBITING CALCIFICATION OF A MACROPHAGE-DERIVED MATRIX VESICLE - The invention relates to methods for decreasing, inhibiting, preventing, or reducing matrix vesicle induced calcification by inhibiting the amount or formation of a complex comprising phosphatidylserine (PS), annexin II, annexin V or VI, and S100A9 or S100A12 in a macrophage. | 2015-11-05 |
20150315578 | IDENTIFICATION OF NOVEL GENES CODING FOR SMALL TEMPORAL RNAS | 2015-11-05 |
20150315579 | DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION - The present invention provides double stranded compositions wherein the first strand is modified to have a particular motif and the second strand is modified a selected motif. The motifs are defined by positioning of differentially modified nucleosides wherein at least the sugar moieties are different. More particularly, the present compositions comprise an antisense strand that is modified to have a positional/full motif and the sense strand is modified to have an alternating motif, a hemimer motif, a blockmer motif, a gapped motif, a positional motif, a positional/full motif or a fully modified motif. Each strand further comprises one or more phosphorothioate internucleoside linkage. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression. | 2015-11-05 |
20150315580 | COMPOUNDS AND METHODS FOR IMPROVING CELLULAR UPTAKE OF OLIGOMERIC COMPOUNDS - The present invention provides method of optimizing the efficacy and potency of antisense drugs. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipeints for improved cellular uptake. | 2015-11-05 |
20150315581 | SIGNAL ACTIVATABLE CONSTRUCTS AND RELATED COMPONENTS COMPOSITIONS METHODS AND SYSTEMS - Provided herein are signal activatable molecular constructs for delivery of molecules and related components, compositions, methods, and systems, having a 17 to 30 by targeting domain duplex RNA, at least one protection strand having a protection segment and linker segment and a sensor strand having a displacement segment and a toehold segment, in which in an inactive conformation the protection segment and the displacement segment form a sensor domain duplex polynucleotide covalently attached to the targeting domain and presenting the toehold segment for binding to a signal molecule. In an active conformation the sensor strand is bound to the signal molecule and is detached from the at least one protection strand and from the targeting domain; and the targeting domain attaches the at least one protection strand in a configuration allowing processing by Dicer and/or an Argonaute enzyme. | 2015-11-05 |
20150315582 | DEEP INTRONIC TARGET FOR SPLICING CORRECTION ON SPINAL MUSCULAR ATROPHY GENE - The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene. The compositions and methods of the instant invention include short oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target sites in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The target regions include a unique RNA structure and a 6-nucleotide long sequence that is essential for initiating a long distance steric inhibitory interaction. The identified region provides a novel target deep within SMN2 intron 7. Intronic targets are highly desirable as annealing of an ASO to an intron does not interfere with translation and transport of mRNA. The invention also provides opportunity to employ a short antisense oligonucleotide or a small compound against the unique RNA structure responsible of SMN2 exon 7 skipping in SMA. | 2015-11-05 |
20150315583 | METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF CKAP5 BY DOUBLE-STRANDED RNA - This invention relates to compounds, compositions, and methods useful for reducing CKAP5 target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents. | 2015-11-05 |
20150315584 | COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN C-III EXPRESSION - The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia). | 2015-11-05 |
20150315585 | MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS HAVING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 2015-11-05 |
20150315586 | METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 2015-11-05 |
20150315587 | MULTIMERIC OLIGONUCLEOTIDES COMPOUNDS HAVING CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 2015-11-05 |
20150315588 | METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 2015-11-05 |
20150315589 | METHODS OF INHIBITING CANCER STEM CELLS WITH HMGA1 INHIBITORS - The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with HMGA1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using HMGA1 inhibitors. | 2015-11-05 |