41st week of 2014 patent applcation highlights part 40 |
Patent application number | Title | Published |
20140302458 | Dental Implant With Coded Upper Surface - A dental implant for insertion into bone within a patient's mouth comprises a body and a scannable code. The body includes a bone-engaging exterior surface, an anti-rotational feature for non-rotationally mating with an abutment, and an upper region. The upper region includes an upper surface for engaging the abutment. The scannable code on the upper surface provides information concerning the dental implant. The information includes at least two features of the dental implant. | 2014-10-09 |
20140302459 | Method of dental implant restoration - The invention provides a method for dental restoration including direct modification or customization of a final abutment inside the patient's mouth. The final abutment is made from a non-titanium material. The final abutment, after being completely modified or customized, may then be used to support a crown. The invention exhibits numerous merits such as simplified procedure, cost-effectiveness, reduction of laboratory adjustment, reduction of chair time, and reduction of dentist office visits. | 2014-10-09 |
20140302460 | DENTAL IMPLANT AND METHOD FOR PRODUCING A DENTAL IMPLANT - In a dental implant ( | 2014-10-09 |
20140302461 | METHOD OF DRIVING A MAIN ROTOR OF A ROTORCRAFT IN THE CONTEXT OF SIMULATING A FAILURE OF ONE OF THE ENGINES OF THE ROTORCRAFT - A method of driving a main rotor of a rotorcraft in rotation while implementing an in-flight simulation mode that simulates failure of one of the engines of the rotorcraft. In simulation mode, and when a current speed of rotation (NR) of the main rotor is detected as being lower than a predetermined threshold speed of rotation (S), the simulation mode is kept active and a regulation command is generated in order to perform a controlled operation (A) of gradually increasing the power delivered by the engines by authorizing the limit imposed by a setpoint (OEI/2) for regulating operation of the engine in simulation mode to be exceeded. Said gradually increasing power is interrupted by the pilot staying under training and operating a collective pitch manoeuver of the blade of the main rotor providing a rotation of main rotor at the predetermined threshold speed in rotation. | 2014-10-09 |
20140302462 | Motion Simulation System Controller and Associated Methods - A motion simulation system includes actuators having a planetary gearbox engaged with and driven by a servomotor engaged with a crank. A connector rod is engaged with the crank of each actuator, and engaged with a platform configured to attach to a vehicle. A control system is operable with each electric servo motor of each actuator for delivering control for providing a simulated motion to the top plate. Control data is sent to the servomotors using a msec data send and receive rate, with internal processing within the nano-second range. Such update rates coupled with a real time, dynamically responsive motion controller results in a desirably smooth and accurate simulator motion. The control system includes a washout filter for transforming input forces and rotational movements. One to six degrees of freedom systems having smooth performance with high payload capability are provided. | 2014-10-09 |
20140302463 | MNEMONIC-BASED LANGUAGE-LEARNING SYSTEM AND METHOD - The current document discloses computer-based methods and systems that employ mnemonics for teaching foreign languages to students of foreign languages. The currently disclosed computer-based and mnemonics-based language learning system is, in the described implementation, a distributed computational system that provides a collaborative computational environment in which students of foreign languages create, edit, discuss, and use mnemonics-based dictionaries and language-learning resources. | 2014-10-09 |
20140302464 | SYSTEM AND METHOD FOR LEARNING FOREIGN LANGUAGE OVER A SECURED SOCIAL NETWORK BASED ON BILINGUAL MESSAGING - A system and method for encouraging communication in different languages over a secured network that connects social circles (e.g., schools, kindergartens, etc.) and remote participants who are engaged in learning from each other's native languages as foreign languages are provided. | 2014-10-09 |
20140302465 | PROCESS FOR DISPLAYING AN ACTION VIGNETTE WHILE TEXT OF A PASSAGE ASSOCIATED WITH THE ACTION VIGNETTE IS CORRECTLY READ ALOUD - A method for teaching a person, such as a child, to read aloud is disclosed. The method is implemented as a voice activated, visual software application that provides a visual display of a story as the person reads the words of the story. The method provides pronunciation assistance to the person, which in the software includes a simulated “teacher” that helps the person with assistance in reading the story. The method progresses through a sequence of story passages which together represent the entire story. The method progresses to each story passage upon successful completion of the current story passage by the person reading the story, such that the method will not allow the visual story to progress for the reader if a word is not read correctly out loud. | 2014-10-09 |
20140302466 | Method, system, and apparatus for authoring, transforming, and reading text enhanced with guidance symbols and formatting - A text reading system for authoring, transforming, and reading enhanced text that contains reading guidance symbols and formatting, for the purpose of providing a reader with guidance on the location of words and the direction of reading in the enhanced text, and enhancing reading comprehension and reading speed, includes an authoring component, a text transformation component, an enhanced text repository, and an enhanced text reader. The enhanced text reading system takes as data input either standard text from a standard text repository, or text written by a human author, while using the authoring component. The reading system produces text that is enhanced with reading guidance symbols and formatting, and stored in an enhanced text repository. Furthermore disclosed is a method for authoring, transforming, and reading text; and an apparatus for reading enhanced text, including a processor, a memory, an input/output, a screen, an enhanced text viewer, and other optional components. | 2014-10-09 |
20140302467 | SALES RESPONSE TRAINING SYSTEM AND METHODS - Embodiments of the invention describe the implementation and execution of situational response training (SRT). In some embodiments, a sales team can use an SRT to implement real-time, peer-reviewed and/or focused training. For example, a manager can prepare a training situation through a web interface and then verbally record the training through a telephone interface. The training situation can include any number of questions, scenarios, fact patterns, etc. that can require a response by members of the sales team. Once prepared, the manager can send the training situation to his sales team. The sales team can then prepare and respond to the training situation over the phone using an interactive voice response (IVR) system or through another communication channel. For example, the training situation can be sent via email requesting that each member of the sales team respond to the training situation through a telephone interface. | 2014-10-09 |
20140302468 | Monitoring Cleaning of Surfaces - A method for monitoring cleaning of a surface includes applying an amount of transparent indicator material to an area of a surface and measuring the amount of transparent indicator material remaining on the surface. The transparent indicator material may be fixed on the surface by drying and, when a fluorescent material, may be measured through exposure to ultraviolet radiation. | 2014-10-09 |
20140302469 | Systems and Methods for Providing a Multi-Modal Evaluation of a Presentation - Systems and methods are described for providing a multi-modal evaluation of a presentation. A system includes a motion capture device configured to detect motion an examinee giving a presentation and an audio recording device configured to capture audio of the examinee giving the presentation. One or more data processors are configured to extract a non-verbal feature of the presentation based on data collected by the motion capture device and an audio feature of the presentation based on data collected by the audio recording device. The one or more data processors are further configured to generate a presentation score based on the non-verbal feature and the audio feature. | 2014-10-09 |
20140302470 | Managing lifestyle resources system and method - Some embodiments provide a lifestyle management system for managing delivery of lifestyle information associated as an aggregation of lifestyle resources. Embodiments of the invention involve systems, methods, computer program products, and the like, for providing lifestyle information through a single interface for a user's mobile device. Some embodiments include a lifestyle management system including relational model for defining social relationships between users with one or more relationship links defining a data relationship and/or information flow between lifestyle resources data stored on a non-transitory computer-readable storage medium. In some embodiments, the interface can provide tools to manage lifestyle resources available to a user of a mobile device such that the user can better manage the user's healthcare and lifestyle needs. The interface can also improve the efficiency of accessing and organizing lifestyle resources by gathering one or more user preferences and measuring the user's engagement with the provided resources. | 2014-10-09 |
20140302471 | System and Method for Controlling Gaming Technology, Musical Instruments and Environmental Settings Via Detection of Neuromuscular Activity - A system and method for controlling gaming technology, musical instruments and environmental settings via detection of neuromuscular activity are disclosed herein. The disclosed system generally comprises a sensor grid coupled to a user; a base station configured to receive neuromuscular activity inputs from one or more sensors in said sensor grid, determine whether said neuromuscular activity inputs received from said one or more sensors is within a calibrated boundary value for an activity associated with each of said one or more sensors, and instruct a physical device or software to perform said activity when said neuromuscular activity input received from said one or more sensors is within said calibrated boundary value for the activity associated with each of said one or more sensors; and at least one said physical device or said software being configured to receive instructions from said base station. The disclosed system allows a user to perform an activity that the user might otherwise be unable to perform. | 2014-10-09 |
20140302472 | LAMAZE BREATHING COACH - A system for coaching breathing techniques includes a processor and storage device. An input receiver connected to the processor receives selection of a selected breathing technique. When executed, the processor causes a presentation in a first portion of the display device representing a desired breathing pattern based on the selected breathing technique. The processor monitors breathing sounds from a microphone and causes a presentation in a second portion of the display device representing an actual breathing pattern of a user. The processor correlates the actual breathing pattern with the desired breathing pattern based on the selected breathing technique and provides directions to the user to inhale and exhale according to the selected breathing technique. An image acquisition device acquires image data of the user. The processor correlates the image data of the user with predetermined relaxation images and provides directions to the user to establish a relaxing posture. | 2014-10-09 |
20140302473 | STETHOSCOPY TRAINING SYSTEM AND SIMULATED STETHOSCOPE - Provided is a stethoscopy training system which is inexpensive and has a simple configuration, without using a device which measures a respiratory operation of a simulated patient. The stethoscopy training system for this objective is formed from: a simulated stethoscope ( | 2014-10-09 |
20140302474 | CENTRAL LINE SIMULATION AND TRAINING DEVICE - An anatomical simulation training device is disclosed in an embodiment herein. The anatomical device includes an anatomical model comprising a quadrant of a torso. The model includes a first opening and a second opening, wherein a first passageway connects between the first and the second opening. The model further includes a third opening, wherein a second passageway connects between the third opening and the second opening. The first passageway is configured to receive a first conduit, and the second passageway is configured to receive a second conduit. The first and second conduits are removable and replaceable. The model is comprised of, in part or in whole, a hydrogel, and said model quadrant torso mimics at least a portion of a human or non-human animal quadrant torso, and simulates at least one predetermined physical characteristic of a human or non-human animal torso with at least fifty percent or more similarity. | 2014-10-09 |
20140302475 | CRICOTHYROIDOTOMY SIMULATION DEVICE - An artificial anatomical model used in an embodiment as a simulation and training device for performing a cricothyroidotomy procedure on a patient having an upper airway obstruction is provided. Furthermore, the simulation device includes a mandible and neck base structure that geometrically mimicsa human mandible and neck region with corresponding anatomical landmarks such that a cricothyroidotomy procedure can be performed on the device for training purposes in some embodiments. Moreover, various components of the device are easily removable and replaceable independent of one another, further simplifying the training process. | 2014-10-09 |
20140302476 | COMPUTER-AIDED TRAINING SYSTEMS, METHODS AND APPARATUSES - The present invention discloses computer aided training methods, apparatuses, systems and media. A computer aided training system according to one embodiment comprises a workstation ( | 2014-10-09 |
20140302477 | INTELLIGENT INTERACTIVE REMOTE TEACHING SYSTEM - The present invention provides an intelligent interactive remote teaching system which includes an interactive logic control unit, interactive script builder, a video player and the infrastructure. The teacher builds corresponding interactive scripts after they record the multimedia teaching video, associates the interactive scripts and the recorded multimedia teaching video, and triggers corresponding interactive content and controlling actions according to the interactive logic to realize the interaction with the learner. By using the present invention, the teacher can build the interactive script conveniently while does not know how to program. The teacher makes the repeated interactive behavior to be implemented by the intelligent interactive video, thus reduces the cost of the interactive time and space between the teacher and the learner. Further, the present invention takes the asynchronous video to integrate learning resources, that can direct the students to learn by themselves in clear targets. | 2014-10-09 |
20140302478 | CENTRALIZED TRAINING EXERCISE CONTROL PROCESS - A method to conduct operations-based training exercises is described herein including one or more control groups, one or more observation groups and one or more training audiences subjected to implementer and/or injects, the method comprising the one or more control groups directing the one or more observation groups to specific positions by utilizing real time communication, the one or more observation groups observing the one or more training audiences and recording observations, the one or more observation groups uploading the observations to a database accessible by the one or more control groups, and the one or more control groups retrieving and analyzing the observations and, optionally, modifying the operations-based training exercises. | 2014-10-09 |
20140302479 | BRIDLE AND HALTER INSTRUCTIONAL METHOD - An instructional system for placing headgear on an animal such as a horse including a headgear assembly such as a halter or bridle, wherein the headgear assembly further includes multiple interconnected structural components; and a plurality of individual color-coded sleeves releasably mounted on certain of the independent interconnected components, wherein the color of each of the color-coded member corresponds both to a predetermined location on the head of the animal and to a particular step in a predetermined method for placing the headgear assembly on the head of the animal. | 2014-10-09 |
20140302480 | COMPOSITE TISSUE GRAFT AND MATERIALS AND METHODS FOR ITS PRODUCTION AND USE - The technology described herein is directed to tissue engineering, e.g. to biomimetic compositions as well as methods and devices related to producing a biomimetic composition. | 2014-10-09 |
20140302481 | System and Method for Electrophoretic Decellularization - A device for decellularizing a tissue includes a container, first and second electrodes disposed within the container and defining a space between the first and second electrodes to receive the tissue, a perfusion pump, and a conduit connected to the perfusion pump to transport a decellularization solution from the pump into the tissue. | 2014-10-09 |
20140302482 | ELECTROMAGNETIC BLOOD PRESERVATION AND STORAGE - Embodiments of the present invention include method, system and apparatus for storing fluids (including whole blood or any of the components thereof) to thereby enhance viability of the fluids being stored outside a living body. Embodiments of the present invention include, for example, exposing an electric, magnetic, electromagnetic, field or combinations thereof to one or more storage mediums containing the fluids. Embodiments of the fields exposed to the blood or components thereof thereby causing one or more cells to be repelled from the field to reduce the risk of the one or more cells from sticking together. Embodiments of the claimed invention advantageously extend the viability or shelf life of the blood or components thereof. Embodiments of the present invention can further include a pump for circulating the fluids and a warmer to maintain a constant temperature. | 2014-10-09 |
20140302483 | CELL SEPARATION METHOD - The present invention provides methods and compositions for separating cells from a sample containing erythrocytes. The method is for recovering desired cells from a sample containing the desired cells, erythrocytes and undesired cells comprising: a) contacting the sample with a composition, said composition comprising: i) an erythrocytes aggregation reagent ii) at least one antigen recognizing moiety coupled to a magnetic particle, wherein said particle with said at least one antigen recognizing moiety specifically binds to at least one antigen specific for one or more undesired cellular components; b) applying simultaneously i) gravity sedimentation for sedimentation of erythrocytes and ii) a magnetic field gradient to said sample for immobilizing said magnetic particle generating a pellet and a supernatant phase, and c) recovering the desired cells from the supernatant phase. Compositions for the use within the present method are also disclosed. | 2014-10-09 |
20140302484 | METHODS FOR THE PREPARATION OF HYDROGELS USING LIPASE ENZYMES - The present invention relates to an improved method for preparing hydrogels, such as alginate hydrogels. The hydrogels of the present invention is in particular useful for immobilisation and preservation of biological material, such as cellular material, e.g. spermatozoa. | 2014-10-09 |
20140302485 | Integrated Temperature Control of Laboratory Instrument - This invention describes an advanced cooling system for a laboratory instrument to maintain laboratory samples at a predetermined temperature. The advanced cooling system uses an algorithm that incorporates information from at least one sensor and other operational parameters including thermal effects from the operation of the instrument. | 2014-10-09 |
20140302486 | SYSTEMS AND METHODS FOR DETECTING BIOMARKERS OF INTEREST - A detection probe for detecting single base mutations or alterations in a double stranded target nucleic acid molecule is provided. In some aspects, the detection probe may include a double-stranded probe nucleic acid molecule having a first end and a second end; at least one probe initiation toehold at the first end; at least one substance capable of emitting a detectable signal at the second end; and optionally, at least one dissociation toehold at the second end. The detection probe is designed to hybridize with a double stranded target nucleic acid in a reaction which proceeds at approximate thermodynamic equilibrium (ΔG≈0) when no single base mutations or alterations are present in the double stranded target nucleic acid molecule. The probe may be used in detection systems and methods to identifying the presence or absence of one or more single base mutations or alterations in a double-stranded nucleic acid target molecule. | 2014-10-09 |
20140302487 | Recombinant Phage and Bacterial Detection Methods - Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise | 2014-10-09 |
20140302488 | Vaccine Diagnostics - The present invention relates to improved diagnostic methods and kits for differentiating between (a) animals administered a chimeric pestivirus, and (b) animals infected with a wild-type bovine viral diarrhea virus (BVDV) or immunized with a conventional BVDV vaccine. | 2014-10-09 |
20140302489 | IDENTIFICATION OF PROTECTIVE ANTIGENIC DETERMINANTS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND USES THEREOF - The invention relates to a polypeptide of a protective antigenic determinant (PAD polypeptide) of porcine reproductive and respiratory syndrome virus (PRRSV) and nucleic acids encoding a PAD polypeptide. The PAD polypeptide and nucleic acids encoding a PAD polypeptide are useful in the development of antibodies directed to PAD, vaccines effective in providing protection against PRRSV infection, and diagnostic assays detecting the presence of PAD antibodies generated by a PAD-specific vaccine. The invention also discloses methods of generating antibodies to PAD, for vaccinating a pig to provide protection from PRRSV infections, a method of preparing the vaccine, a method of treating PRRSV infections in a pig, and a method of detecting antibodies to PAD of PRRSV. | 2014-10-09 |
20140302490 | METHOD AND DEVICE FOR OPTICAL ANALYSIS OF PARTICLES AT LOW TEMPERATURES - Method and device ( | 2014-10-09 |
20140302491 | Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids - Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue. Cultures are initiated with fragments of mammalian tissue, which are then cultured embedded in a gel substrate that provides an air-liquid interface. Cultured explants of the invention can be continuously grown in culture for a year or more, while maintaining features of the tissue including prolonged tissue expansion with proliferation, multilineage differentiation, and recapitulation of cellular and tissue ultrastructure. | 2014-10-09 |
20140302492 | METHOD OF DETECTING AND/OR QUALIFYING AN ANALYTE IN A BIOLOGICAL SAMPLE - An aptamer-based SERS detection technique that directly monitors an aptamer-analyte capture event by generating spectroscopic information regarding the identity of the analyte that has been bound to the aptamer from a complex biological sample. A reproducible SERS spectrum is measured for an aptamer-analyte complex formed on a metal surface and this spectral information is used directly to identify the specific aptamer-analyte complex and optionally also to quantify the analyte in the sample, thus enabling discrimination between true and false positives in quantitative analyte assays on complex biological samples. In one embodiment the aptamer is attached directly to the metal surface and surrounded by a self-assembled monolayer (SAM) of amphiphilic molecules. In an alternative embodiment the metal surface is coated with a SAM and the aptamer is attached to the amphiphilic molecules of the SAM. | 2014-10-09 |
20140302493 | METHOD AND QUALITY CONTROL MOLECULAR BASED MOUSE EMBRYO ASSAY FOR USE WITH IN VITRO FERTILIZATION TECHNOLOGY - A method for qualitatively assessing products used in in vitro fertilization is provided. Also disclosed is an improved quality control assay for use in clinical Assisted Reproductive Technologies (ART). | 2014-10-09 |
20140302494 | METHOD OF ANALYZING A BRCA2 GENE IN A HUMAN SUBJECT - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 2014-10-09 |
20140302495 | NOVEL LISTERIA BACTERIOPHAGE TAILSPIKE PROTEIN AND USES THEREOF - The present invention relates to a novel tail spike protein (TSP) encoded by the novel | 2014-10-09 |
20140302496 | MULTIMODAL METHODS FOR SIMULTANEOUS DETECTION AND QUANTIFICATION OF MULTIPLE NUCLEIC ACIDS IN A SAMPLE - Described herein are approaches for the detection, identification, and/or quantification of target nucleic acids, including, but not limited to partially, substantially randomly, degraded target nucleic acids, in a biological sample, such as a formalin-fixed, paraffin-embedded (FFPE) sample. These approaches provide a means of detecting, identifying, and/or quantifying target nucleic acid molecules, including DNA and RNA molecules, further including RNAs of different classes, from the same sample, and in the same reaction, by using “expander oligonucleotides,” as the term is defined herein, to convert fragments of target nucleic acids into discretely sized DNA fragments, each with a chosen length characteristic for the target nucleic acid from which it is derived. | 2014-10-09 |
20140302497 | GENE CONTROLLING FRUIT COLOR PHENOTYPE IN PALM - Methods, compositions, and kits for predicting and controlling fruit color in palm. | 2014-10-09 |
20140302498 | RAPID DETECTION OF THE "HIGH VIRULENT" ST-17 CLONE OF GROUP B STREPTOCOCCUS - The present invention relates to polynucleotides enabling the rapid, simple and specific detection of Group B | 2014-10-09 |
20140302499 | PHARMACEUTICAL COMPOSITIONS AND METHODS USEFUL FOR MODULATING ANGIOGENESIS, INHIBITING METASTASIS AND TUMOR FIBROSIS, AND ASSESSING THE MALIGNANCY OF COLON CANCER TUMORS - Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors. | 2014-10-09 |
20140302500 | COMPOSITIONS AND METHODS FOR DETECTING BV-ASSOCIATED BACTERIAL NUCLEIC ACID - Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of a 16S rRNA or its encoding gene from bacterial species associated with bacterial vaginosis. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits. | 2014-10-09 |
20140302501 | MUTATION DETECTION IN HIGHLY HOMOLOGOUS GENOMIC REGIONS - The present invention relates to methods, kits, primers and probes for use in distinguishing highly homologous genomic regions and detecting variants in a locus of interest. In one aspect, the present invention is useful for distinguishing Exon 9 of the CFTR gene from a large homologous region of chromosome 20 in order to determine the presence of the A455E variant. | 2014-10-09 |
20140302502 | Bin1 as a Prognostic Marker in Cardiovascular Disease - The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of a poor outcome in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates as well as in assessing therapy options and efficacy of treatment in congestive heart failure patients. | 2014-10-09 |
20140302503 | COMPOSITIONS, METHODS AND SYSTEMS FOR POLYMERASE CHAIN REACTION ASSAYS - The present disclosure provides methods, devices, systems and compositions for detecting nucleic acids in polymerase chain reaction assays, such as droplet digital polymerase chain reaction (ddPCR) assays. The present disclosure provides methods, devices, systems and compositions for detecting nucleic acids in ddPCR assays using intercalating dyes. A dual surfactant system with at least one fluorosurfactant and at least one non-ionic non-fluorosurfactant may be employed for droplet generation and nucleic acid detection. | 2014-10-09 |
20140302504 | Nucleic Acid Amplification - Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases, ligases, and primers. | 2014-10-09 |
20140302505 | METHODS AND SYSTEMS TO ANALYZE REACTIONS USING AN INFORMATION SYSTEM - Disclosed are example methods and systems to determine the quantity of an analyte initially present in a chemical and or biological reaction. Also disclosed are computer implemented methods and systems to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction. | 2014-10-09 |
20140302506 | METHODS AND KITS FOR SELECTIVELY AMPLIFYING, DETECTING OR QUANTIFYING TARGET DNA WITH SPECIFIC END SEQUENCES - Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying a hypomethylated fetal DNA fragment in a maternal plasma sample containing a corresponding hypermethylated maternal DNA fragment. | 2014-10-09 |
20140302507 | DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION - Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2014-10-09 |
20140302508 | DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION - Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. | 2014-10-09 |
20140302509 | PROCATHEPSIN L AND CATHEPSIN L AS BIOMARKERS FOR ISCHEMIA - The present invention relates to procathepsin L, cathepsin L or a fragment thereof as a biomarker for ischemia. The present invention further relates to methods for diagnosing, predicting, prognosticating and/or monitoring ischemia based on measuring said biomarker, and to related kits, devices and uses thereof. | 2014-10-09 |
20140302510 | METHOD OF DIAGNOSIS, PROGNOSTIC OR TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention relates to a method of diagnosis, prognostic or treatment of neurodegenerative diseases, in particular Alzheimer's disease. | 2014-10-09 |
20140302511 | CANCER STEM CELL-SPECIFIC MOLECULE - An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker Lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective of the present invention is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients. The present inventors discovered that highly pure large intestine cancer stem cells (CSC) can be obtained in a large quantity, and identified the two types of conditions of large intestine CSCs distinguishable through Lgr5 expression. Moreover, the present inventors discovered that an antibody against a cell membrane molecule specifically expressed in said cancer stem cells can damage said cells. | 2014-10-09 |
20140302512 | GENOTOXICITY TESTING - The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding | 2014-10-09 |
20140302513 | METHOD AND QUALITY CONTROL MOLECULAR BASED MOUSE EMBRYO ASSAY FOR USE WITH IN VITRO FERTILIZATION TECHNOLOGY - A method for qualitatively assessing products used in in vitro fertilization is provided. Also disclosed is an improved quality control assay for use in clinical Assisted Reproductive Technologies (ART). | 2014-10-09 |
20140302514 | CANCER SCREENING BY DETECTION OF ULTRASTRUCTURAL AND MOLECULAR MARKERS - The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject. | 2014-10-09 |
20140302515 | BIOMARKERS FOR BREAST CANCER PATIENTS - Kaiso, a transcriptional regulator with bimodal DNA-binding specificity, is over-expressed in breast cancer cells, and its nuclear localization is correlated with malignant and lymph node metastasis. Depleted expression of Kaiso in those cells results in a significant decrease in basal and EGF-induced cell migration, and this is associated with increased E-cadherin expression. The data reported and described herein provide significant evidence that Kaiso is involved in breast cancer invasion and metastasis. Kaiso nuclear localization is a biomarker that is associated with invasive and metastatic infiltrating ductal breast cancer that may be used to monitor, detect, and/or track the progress of disease in a patient. | 2014-10-09 |
20140302516 | POLYMER DOT COMPOSITIONS AND RELATED METHODS - Lyophilized polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions and kits supplying the compositions. | 2014-10-09 |
20140302517 | ANTI-IDIOTYPE ANTIBODY AGAINST ANTI-C-MET ANTIBODY - Disclosed are an anti-idiotype antibody that specifically binds to an idiotope site of an anti-c-Met antibody, the use of the anti-idiotype antibody for detecting the anti-c-Met antibody, and methods, polypeptides, polynucleotides, compositions, and vaccines related thereto. | 2014-10-09 |
20140302518 | DETECTION OF INFECTIOUS PRION PROTEIN BY SEEDED CONVERSION OF RECOMBINANT PRION PROTEIN - The present disclosure relates to methods and compositions for the detection of infectious proteins or prions in samples, including the diagnosis of prion related diseases. One embodiment is an ultrasensitive method for detecting PrP-res (PrP | 2014-10-09 |
20140302519 | ENDOGLYCOSIDASE FROM STREPTOCOCCUS PYOGENES AND METHODS USING IT - The invention provides an endoglycosidase, referred to as EndoS49 and having the amino acid sequence of SEQ ID NO: 1. EndoS49 was isolated from | 2014-10-09 |
20140302520 | METABOLISM OF SOD1 IN CSF - The disclosure relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the disclosure relates to a method for measuring the metabolism of central nervous system derived biomolecules in a subject in vivo. Further disclosed are methods for measuring the in vivo metabolism (e.g. the rate of synthesis, the rate of clearance) of neurally derived biomolecules, such as superoxide dismutase 1 (SOD1). | 2014-10-09 |
20140302521 | SAMPLE PRESERVATION METHOD AND SAMPLE PRESERVATION SUBSTRATE - The invention discloses a cellulose or glass fibre paper for preservation of biological samples, which comprises 4-30 wt % of a hydrophilic branched carbohydrate polymer. It also discloses a method for preservation of biological samples by applying and drying them on the paper. | 2014-10-09 |
20140302522 | METHOD FOR PREDICTING THE PRESENCE OF REPRODUCTIVE CELLS IN TESTIS - The present invention relates to testicular germline markers and their use for predicting the presence or not of reproductive cells in testis of an infertile or hypo fertile male subject. | 2014-10-09 |
20140302523 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same - The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. The present invention further includes a method of identifying or validating a protein of interest as a therapeutic target for treatment of a disease state or condition. | 2014-10-09 |
20140302524 | ANTIBODIES THAT BIND TO LYSYL OXIDASE-LIKE 2 (LOXL2) AND METHODS OF USE THEREFOR - The present disclosure provides lysyl oxidase-like-2 (LOXL2) polypeptide binding agents, including, for example, antibodies that specifically bind a LOXL2 polypeptide; and further provides compositions comprising same. The binding agents can be used in various treatment and diagnostic methods, which are also provided. | 2014-10-09 |
20140302525 | METHODS OF IDENTIFYING SENP1 INHIBITORS - Provided herein are methods of detecting binding of an SENP1 polypeptide to a compound and methods for screening for inhibitors of SENP1. Further provided are aqueous compositions comprising SENP1 polypeptides and NMR apparatuses comprising the compositions for NMR analysis. | 2014-10-09 |
20140302526 | ZAP-70 DETECTION IN CHRONIC LYMPHOCYTIC LEUKEMIA - Detection of ZAP-70 expression provides important information about disease progression and overall survival in patients with chronic lymphocytic leukemia (CLL). The invention provides methods for diagnosing CLL in a subject, as well as methods for clearly distinguishing CLL patients with aggressive form of the disease. A consistent number of B cells from patient blood is isolated and lysed to release all of the intracellular ZAP-70 protein. The released ZAP-70 protein is subsequently extracted by immunomagnetic separation followed by detection with fluorescence immunosandwich assay. The ZAP-70 fluorescence signal is measured with Signalyte™-II spectrofluorometer. The VeriZAP™ assay is a simple, reliable, and reproducible method for quantitative detection of ZAP-70 in patient leukemic cells, and can be used as a prognostic test to distinguish indolent versus aggressive CLL patients. | 2014-10-09 |
20140302527 | TARGET-SPECIFIC PROBE COMPRISING FERRITIN PROTEIN AND DETECTION FOR BIOMARKER USING THE SAME - This invention relates to a target-specific probe containing a ferritin fusion protein and a targeting agent, a target-specific imaging probe containing a labeling agent coupled to the target-specific probe, and a detection method or detection kit of a biomarker using these probes. | 2014-10-09 |
20140302528 | IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS - The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al. | 2014-10-09 |
20140302529 | FILTERING PARTICLES FROM BLOOD OR OTHER MEDIA - A filter element ( | 2014-10-09 |
20140302530 | CMV GLYCOPROTEINS AND RECOMBINANT VECTORS - This invention also relates to recombinant vectors expressing one or more of the human CMV (HCMV) glycoproteins US2, US3, US6 and US11 or corresponding functional rhesus CMV (RhCMV) homologues Rh182, Rh184, Rh185 or Rh189, methods of making them, uses for them, expression products from them, and uses for the expression products. This invention also relates to recombinant cytomegalovirus vectors vectors lacking one or more of the glycoproteins, methods of making them, uses for them, expression products from them, and uses for the expression products. | 2014-10-09 |
20140302531 | ENZYMATIC ACTIVITY BASED-DETECTION - Disclosed herein are methods and kits which are useful for detecting presence of an enzyme in a test sample based upon the intrinsic enzymatic activity of such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes. | 2014-10-09 |
20140302532 | METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY - The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein. | 2014-10-09 |
20140302533 | ADVANCED DETECTION OF SEPSIS - The present invention relates to methods, monitors and systems, useful, for example, for advanced detection of sepsis in a subject. | 2014-10-09 |
20140302534 | ANTI-CANINE N-TERMINAL PRO-ATRIAL NATRIURETIC PEPTIDE ANTIBODY, AND IMMUNOLOGICAL MEASUREMENT METHOD AND IMMUNOLOGICALLY MEASURING KIT USING THE SAME - The anti-canine N-terminal pro-atrial natriuretic peptide antibodies (anti-canine NT-proANP antibodies) according to the present invention comprise anti-canine NT-proANP recognizing a partial portion or a whole portion of the amino acid sequence 31 to 67 of canine NT-proANP and anti-canine NT-proANP recognizing a partial portion or a whole portion of the amino acid sequence 68 to 98 thereof. The anti-canine NT-proANP antibodies are useful for immunologically measuring canine NT-proANP involved in heart diseases and infections of companion animals such as dogs, such as heart failure, mitral valve insufficiency and filariasis. The immunochromatographic assay using the immunochromatographic means such as immunochromatographic strip is extremely convenient and simple for measuring canine NT-proANP and is used as hand-carried and simple devices. | 2014-10-09 |
20140302535 | PROCESS FOR DETECTION OF ALZHEIMER'S DISEASE FROM A SERUM SAMPLE - Disclosed is a method of detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI). Also disclosed is a process for detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI) comprising (a) detecting a first concentration of lipocalin-PDS/TTR complex in a blood sample or urine sample from the subject, (b) determining a second concentration of PDS/TTR complex in a blood sample or urine sample from an unaffected individual, and (c) comparing the first and second concentrations, wherein a lower first concentration as compared to the second concentration is indicative of the subject having or being at risk of developing Alzheimer's disease. | 2014-10-09 |
20140302536 | DIAGNOSIS OF PULMONARY AND/OR CARDIOVASCULAR DISEASE - Described are methods and kits for determining the likelihood of the presence of cardiovascular disease (CVD) or pulmonary disease (PD) in a subject using ST2/Interleukin 1 Receptor Like 1 (IL1RL1) and/or Interleukin 33 (IL-33), and a biomarker for CVD, e.g., a natriuretic peptide, e.g., brain natriuretic peptide (BNP), prohormone BNP (proBNP), N-Terminal proBNP (NT-proBNP), atrial natriuretic peptide (ANP), proANP, or NT-proANP. | 2014-10-09 |
20140302537 | Use of Female Mammal's Urine for Determination of Fetal Gender Related Characteristics - The present invention provides a method for determining the gender of a fetus by assaying the sex hormones, evaluating the overall reducing/oxidizing (redox) activity, and/or evaluating the radical scavenging capacity of the maternal urine or other body fluid. The method can be used to determine fetal gender at any time point during the entire pregnancy. The body fluid may be processed before assaying. Processing may involve aging the body fluid, or purification of various fractions. | 2014-10-09 |
20140302538 | MARKERS FOR PREECLAMPSIA - This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided. | 2014-10-09 |
20140302539 | COELENTERAZINE ANALOGS - Coelenterazine analogs having luminescence properties different from those of known coelenterazine analogs are desired for various luciferases. The invention provides compounds represented by general formula (1) below. | 2014-10-09 |
20140302540 | BLOOD SAMPLE ASSAY METHOD - The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which serves to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint. Step iii) may be carried out at any stage up to and including step iv) but before steps v) or vi). The reagent of step iii) may be applied to the sample separately or may be included in a reagent mixture during steps i) or iv). A corresponding kit is also provided. | 2014-10-09 |
20140302541 | METHODS OF DETERMINING AN ANALYTE CONCENTRATION, AS WELL AS DEVICES AND TEST ELEMENTS INCORPORATING THE SAME - Methods, devices and test elements are disclosed for detecting at least one analyte in a sample. The methods, devices and test elements are used for detecting one or more analytes such as metabolites in body fluids, especially glucose. The methods, devices and test elements correct for an interfering variable such as temperature and or hematocrit in a test element system via a correction factor based upon diffusion of a diffusable label. | 2014-10-09 |
20140302542 | FLAVIN-BINDING GLUCOSE DEHYDROGENASE HAVING IMPROVED SUBSTRATE SPECIFICITY - A flavin-binding glucose dehydrogenase having high substrate specificity for D-glucose and decreased reactivity to D-xylose and/or maltose. More specifically, a flavin-binding glucose dehydrogenase having one or more amino acid substitutions at a position corresponding to position 78, position 79, position 81, position 121, position 122, position 123, position 569 and position 612 of | 2014-10-09 |
20140302543 | STRATEGY FOR THE ASSAY OF ENZYME AND ENZYME MIXTURES FOR THE HYDROLYSIS LIGNO-CELLULOSIC BIOMASS - The invention is to a novel method for assaying most or all of the activities of an enzyme or enzyme solution that could be used to convert ligno-cellulosic material into monomeric sugars. The method characterizes enzymes and enzyme mixtures for the hydrolysis of ligno-cellulosic biomass by measuring the protein concentration of an enzyme or enzyme mixture, adding the enzyme or enzyme mixture to a plurality of test vials creating a liquid fraction in the plurality of test vials wherein each test vial in the plurality of test vials contains a different substrate, incubating each test vial for a period of time sufficient to establish the conversion of the substrate in each test vial of the plurality of test vials at the same pH and temperature, while, if necessary, providing at least enough agitation to keep the substrate in suspension, quenching the reaction, and analyzing the optical absorbance of the liquid fraction of at least one test vial of the plurality of test vials. | 2014-10-09 |
20140302544 | A-FUCOSYLATION DETECTION IN ANTIBODIES - This invention describes a new analytical method to determine the quantity and distribution of fucose per Fc within an antibody preparation. | 2014-10-09 |
20140302545 | ENZYME TREATMENT APPARATUS FOR PROTEINS USING A HOLLOW FIBER MEMBRANE, AND ON-LINE PROTEOMICS METHOD USING SAME - Provided are an enzyme treatment apparatus for proteins using a hollow fiber membrane and an on-line proteomics method using same. The enzyme treatment apparatus for proteins according to the present invention can increase a recovery rate of peptides, which are recovered through an enzyme treatment process, by basically solving the problem of low reproducibility of an enzyme activity which may occur during a conventional enzyme treatment process, and can also reduce a time for purification and provide higher yield by performing separation and purification through a single step. In particular, the present invention can be usefully applied for developing a disease-specific protein biomarker through a statistical analysis method having highly efficient detectability for proteins in research for finding biomarkers related to human diseases. | 2014-10-09 |
20140302546 | METHOD FOR HYDROGEN SULFIDE DETECTION - A method for detecting H | 2014-10-09 |
20140302547 | METHODS OF ISOLATING BIPOTENT HEPATIC PROGENITOR CELLS - A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class I antigen(s) can be used for further enrichment of hepatic progenitors. Furthermore, the progenitors can be selected to have a level of side scatter, a measure of granularity or cytoplasmic droplets, that is higher than that in non-parenchymal cells, such as hemopoietic cells, and lower than that in mature parenchymal cells, such as hepatocytes. Furthermore, the progeny of the isolated progenitors can express alpha-fetoprotein and/or albumin and/or CK19. The hepatic progenitors, so isolated, can grow clonally, that is an entire population of progeny can be derived from one cell. The clones of progenitors have a growth pattern in culture of piled-up aggregates or clusters. These methods of isolating the hepatic progenitors are applicable to any vertebrates including human. The hepatic progenitor cell population is expected to be useful for cell therapies, for bioartificial livers, for gene therapies, for vaccine development, and for myriad toxicological, pharmacological, and pharmaceutical programs and investigations. | 2014-10-09 |
20140302548 | MULTIPARAMETRIC METHOD FOR ASSESSING IMMUNE SYSTEM STATUS - The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a clinical event. | 2014-10-09 |
20140302549 | ORGAN-ON-A-CHIP-DEVICE - A self-contained organ-on-a-chip device includes at least one organ growth section comprising at least two organ cavities and a degradable matrix or a micro-channel arranged between the at least two organ cavities. The degradable matrix or the micro-channel is configured to allow for a formation of a capillary network between the at least two organ cavities within the at least one organ growth section. | 2014-10-09 |
20140302550 | CULTURE MEDIUM KIT AND METHOD FOR DETECTION OF MICROORGANISMS - The present invention discloses culture medium unit doses for cultivating microorganisms comprising at least two compositions, each composition packaged in a composition unit dose of a predetermined amount, the composition unit doses being used for combining one of each composition unit dose forming the culture medium unit dose. The composition unit doses being packaged separately and individually until a time the culture medium unit dose is to be prepared for use for cultivation of microorganisms, wherein the time one of each composition unit dose are combined thereby forming the culture medium unit dose. The invention also discloses a method of manufacturing the composition unit doses, and a kit for cultivating microorganisms, the kit comprising a combination of the composition unit doses. | 2014-10-09 |
20140302551 | URINE SAMPLE TESTING APPARATUS AND APPARATUS FOR PROCESSING MEASUREMENT RESULT OF URINE SAMPLE - A urine sample testing apparatus comprises: a urine qualitative measuring section configured to acquire a measurement result for each of a plurality of urine qualitative measurement items; a urine sediment measuring section configured to acquire a measurement result for each of a plurality of urine sediment measurement items; an operation part that is operable by a user to specify a combination of one of the plurality of urine qualitative measurement items and one of the plurality of urine sediment measurement items; an information processing unit configured to determine whether or not a first measurement result of the urine sample obtained by the urine qualitative measuring section and a second measurement result of the urine sample obtained by the urine sediment measuring section have a predetermined relationship with respect to the urine qualitative measurement item and the urine sediment measurement item included in the specified combination. | 2014-10-09 |
20140302552 | Multi-Chambered Tissue Containment System for Molecular and Histology Diagnostics - A container for storing a biological sample is disclosed. The container includes a first chamber having a sidewall extending between an open end and a closed end, defining a first chamber interior adapted to receive a sample holder therein. The container also includes a second chamber having a sidewall extending between an open end and a closed end, defining a second chamber interior adapted to subsequently receive the sample holder therein. The second chamber interior is in fluid isolation from the first chamber interior. A removable closure encloses at least one of the open end of the first chamber and the open end of the second chamber while the sample holder is disposed within one of the first chamber interior and the second chamber interior. A first fluid may be disposed within the first chamber interior, and a second different fluid may be disposed within the second chamber interior. | 2014-10-09 |
20140302553 | BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES - Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. | 2014-10-09 |
20140302554 | NON-IONIC ACID-LABILE SURFACTANTS AND METHODS OF USE - A compound may generally comprise the formula: | 2014-10-09 |
20140302555 | Reduced Genome Bacteria With Improved Genetic Stability - Reduced genome bacteria with improved genetic stability are provided. Also provided are methods of producing polypeptides using the reduced genome bacteria with improved genetic stability. | 2014-10-09 |
20140302556 | CONTROLLING O-GLYCOSYLATION IN LOWER EUKARYOTES - Lower eukaryote host cells in which expression of the endogenous protein mannosyltransferase 2 (PMT2) gene has been disrupted by introducing a nucleic acid molecule encoding a Pmt2p protein having a mutation in a conserved region of the protein. The mutation confers to the host cell resistance to PMT inhibitors, which are used to reduce the amount of O-glycosylation of recombinant proteins produced by the host cells but which also have the effect of reducing the robustness of the host cells during fermentation. When host cells that express the mutated PMT2 gene but not the endogenous Pmt2p are cultivated in the presence of a P MT inhibitor, the host cells display an increase in cellular robustness during fed-batch fermentation and express recombinant pro teins in high yield while the amounts O-glycosylation are similar to that produced under similar conditions by host cells that express only the endogenous P MT2 gene. | 2014-10-09 |
20140302557 | ENGINEERED LOWER EUKARYOTIC HOST STRAINS FOR RECOMBINANT PROTEIN EXPRESSION - The present invention relates to novel engineered lower eukaryotic host cells for expressing heterologous proteins and to methods of generating such strains. | 2014-10-09 |