33rd week of 2011 patent applcation highlights part 38 |
Patent application number | Title | Published |
20110201032 | Immunosensors: scFv-linker design for surface immobilization - An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as | 2011-08-18 |
20110201033 | G IMMUNOGLOBULIN USED AGAINST ANTHRAX TOXINS - An immunoglobulin of the G class (IgG) directed against the protective antigen (PA) of the anthrax toxin, includes:
| 2011-08-18 |
20110201034 | METHOD AND KIT FOR DETECTING ANTIBODY TO AVIBACTERIUM PARAGALLINARUM - A method and a kit for detecting an antibody to | 2011-08-18 |
20110201035 | COMPOSITIONS AND METHODS FOR THE DETECTION OF HIV-1/HIV-2 INFECTION - This invention relates to compositions and methods or the detection of immunodeficiency virs infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies. | 2011-08-18 |
20110201036 | ENDOMETRIOSIS MARKERS - The present invention relates to methods for determining a risk or identifying a condition associated with the presence of endometriosis in a subject as well as testing a candidate compound for a therapeutic activity for the treatment of endometriosis and sorting patients based on the risk of having endometriosis. Specifically, the methods utilize novel markers for assessing the risk of the patient having endometriosis. | 2011-08-18 |
20110201037 | USE OF ERYTHROPOIETIN TO DEVELOP SMALL MOLECULE INHIBITORS OF JANUS KINASE-2 - The invention pertains to a method for identifying compounds that inhibit the erythropoietin-induced JAK2 kinase activity in vivo. The present invention provides a method for detecting small molecule JAK2 inhibitors in a rapidly created rodent model that phenocopies human PV through Epo stimulation. The method comprises the steps of (a) dosing a rodent with erythropoietin (Epo) and a test compound, (b) collecting blood samples after the dose is administered, (c) measuring phosphorylated STAT5 levels in the blood sample, and (d) determining JAK2 inhibitor levels in the blood samples. | 2011-08-18 |
20110201038 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, S100-A12, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2, soluble Hepatocyte growth factor receptor, Interleukin-1 receptor antagonist, Interleukin-1 beta, Interleukin-10, Interleukin-15, Interleukin-3, Myeloperoxidase, Nidogen-1, soluble Oxidized low-density lipoprotein receptor 1, Pappalysin-1, soluble P-selectin glycoprotein ligand 1, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinase 1, Tissue inhibitor of metalloproteinase 2, soluble Tumor necrosis factor, soluble Vascular cell adhesion molecule 1, and Vascular endothelial growth factor A as diagnostic and prognostic biomarkers in renal injuries. | 2011-08-18 |
20110201039 | IMPROVED VIRAL PROTEIN QUANTIFICATION PROCESS AND VACCINE QUALITY CONTROL THEREWITH - A process of quantifying proteins in a complex mixture is provided. The invention has utility in quantifying proteins in a complex preparation of uni- or multivalent commercial or research vaccine preparations. | 2011-08-18 |
20110201040 | NON-MCCJ25-RELATED LARIAT-PEPTIDE INHIBITORS OF BACTERIAL RNA POLYMERASE - The invention provides a method of inhibiting a bacterial RNA polymerases. The invention has applications in control of bacterial RNA polymerase activity, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy. | 2011-08-18 |
20110201041 | ENCAPSULATION OF NANO-MATERIALS FOR FLUID PURIFICATION/SEPARATION - Disclosed is an apparatus and method whereby small particle nano materials may be contained in a highly functional package for fluid separation and/or purification applications. The package consists of an aerogel material which uniformly surrounds the nano-particles. The aerogel may be composed of carbon, silicon, or silicon oxide or other suitable materials. The morphological features of the aerogel may be tailored specifically towards fine particle and ultrafine particle containment while maintaining uniform fluid flow in separation and purification processes. The aerogel may be bonded to a suitable rigid housing by chemical or mechanical means. | 2011-08-18 |
20110201042 | Inhibitors of Bacterial Nitric Oxide Synthase, and Related Screening Methods - The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced in vivo. Therefore they can be used in an assay that measures NO production by bNOS. Using a sensor of the invention one can screen libraries of small molecules for inhibitors of bNOS. | 2011-08-18 |
20110201043 | TRANSGENIC MAMMALS AND CELL LINES FOR THE IDENTIFICATION OF GLUTAMATE TRANSPORTER MODULATORS - The invention includes a transgenic, non-human mammal useful for identifying candidate compounds for treating neurological and/or psychiatric disorders. Incorporated into the genome of the transgenic mammal is a transgene comprising a glutamate transporter promoter operatively linked to a reporter gene. The transgenic, non-human mammal and cells isolated therefrom can be used as an in vivo model for the identification of candidate compounds useful for the treatment of neurological and/or psychiatric disorders. | 2011-08-18 |
20110201044 | TUBERCULOSIS DIAGNOSTIC TEST - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 2011-08-18 |
20110201045 | METHOD AND APPARATUS FOR PERFORMING HEMATOLOGIC ANALYSIS USING AN ARRAY-IMAGING SYSTEM FOR IMAGING AND ANALYSIS OF A CENTRIFUGED ANALYSIS TUBE - A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region. | 2011-08-18 |
20110201046 | T1R HETERO-OLIGOMERIC TASTE RECEPTORS - Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors arc described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell. | 2011-08-18 |
20110201048 | SCREENING METHOD OF THERAPEUTIC AND DIAGNOSTIC AGENTS FOR TNF-ALPHA-INDUCED DISEASES USING REACTIVE OXYGEN SPECIES MODULATOR 1 - Disclosed are methods for screening therapeutics, prophylactics or pain alleviators for diseases induced by TNF-α, a main mediator of inflammation and in ROS production and cell death, and for diagnosing the diseases, and a diagnostic kit. For this, a nucleotide sequence and an amino acid sequence of Romo1, which plays an important role in the ROS production and cell death pathway of TNF-α signaling are utilized. | 2011-08-18 |
20110201049 | COMPOSITIONS FOR THE DETECTION OF MICROBIAL CONTAMINANTS - The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay. | 2011-08-18 |
20110201050 | Gas Scrubbed Perfusion Filter - Fine gas bubbles traveling at fast speed are employed to scrub a hard-surface filter for harvesting liquids from suspensions including those consisting of nutrient media and cell culture, on a continuous basis without clogging the filters. | 2011-08-18 |
20110201051 | CHEMOSENSORY GENE FAMILY ENCODING GUSTATORY AND OLFACTORY RECEPTORS AND USES THEREOF - This invention provides an isolated nucleic acid encoding an insect gustatory or odorant receptor. This invention provides a nucleic acid of at least 12 nucleotides capable of specifically hybridizing with a nucleic acid encoding an insect gustatory or odorant receptor. This invention also provides a purified, insect gustatory or odorant receptor. This invention provides an antibody capable of specifically binding to an insect gustatory or odorant receptor. This invention provides a method of identifying a compound capable of specifically binding to, activating, or inhibiting the activity of an insect gustatory or odorant receptor. This invention also provides methods of controlling insect populations. | 2011-08-18 |
20110201052 | NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 202P5A5 USEFUL IN TREATMENT AND DETECTION OF CANCER - A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 202P5A5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 202P5A5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 202P5A5 can be used in active or passive immunization. | 2011-08-18 |
20110201053 | Recombinant Expression Vector Elements (REVES) for Enhancing Expression of Recombinant Proteins in Host Cells - Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. | 2011-08-18 |
20110201054 | Process for improved recovery of fermentation products from intracellular and extracellular presence - The present invention increases yield of the target fermented molecules by spray drying the fermentation broth and reducing the process volume to nearly one tenth the original. Thus, none of the target molecules are lost and requirements of the solvent and the other conventional method process equipments and processing materials are reduced considerably. Product recovery is improved. A major saving in the waste water treatment offsets spray drying and offers better process economics. | 2011-08-18 |
20110201055 | Engineered cleavage half-domains - Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence. | 2011-08-18 |
20110201056 | Repair of Nucleic Acids for Improved Amplification - Methods and compositions are provided for repairing a polynucleotide so that it can be synthesized efficiently with improved fidelity and yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected from NAD+ or ATP and incubating the polynucleotide with the reaction mixture in the absence of Endonuclease VI. | 2011-08-18 |
20110201057 | Methods for High Fidelity Production of Long Nucleic Acid Molecules with Error Control - A method for synthesizing a nucleic acid having a desired sequence and length comprises providing a solid support having an immobilized nucleic acid, performing a nucleic acid addition reaction to elongate the immobilized nucleic acid by adding a nucleotide or an oligonucleotide to the nucleic acid, determining whether the nucleotide or the oligonucleotide is added to the nucleic acid by detecting whether there is an increase in electrophoretic force applied to the solid support when an electric field and a magnetic field gradient are applied to the support, wherein the increase in electrophoretic force applied to the support is caused by adding the nucleotide or the oligonucleotide to the nucleic acid, repeating the addition reaction and determination steps if the nucleotide or the oligonucleotide is not added to the nucleic acid, and continuing until the immobilized nucleic acid has a desired sequence and length. | 2011-08-18 |
20110201058 | Whole Transciptome Sequencing - Methods for preparing strand-specific sequencing libraries of oligonucleotides using an RNA polymerase promoter to re-transcribe antisense cDNA which has been reverse transcribed from mRNA are provided. The transcription step linearly amplifies sRNA prior to production of double-stranded cDNA to be sequenced and may be sufficient to eliminate the conventional PCR amplification step prior to sequencing. The methods incorporate anchor sequences, amplification sequences and other sequences required for a particular sequencing system or reaction by hybridization and extension of primers, and transcription of RNA, rather than ligation, thus reducing the number of steps and the time required for sample preparation for sequencing of RNA. Use of primer hybridization and transcription reactions in the methods also results in a library that exhibits reduced 3′ sequence bias. | 2011-08-18 |
20110201059 | COMPOSITIONS AND METHODS FOR PRODUCING FERMENTABLE CARBOHYDRATES - Provided herein are methods for producing fermentable sugar obtained from a plant tissue. The methods include providing transgenic plant material comprising one or more locked carbohydrates and contacting plant material with an enzyme capable of converting the locked carbohydrate into a fermentable sugar. The methods are useful for providing sugar or sugar pre-cursors for several industrial purposes including ethanol production. The invention also encompasses plants and plant parts that produce a lock enzyme to yield a locked carbohydrate, with the consequence of accumulating the locked carbohydrate in the plant. The invention also encompasses providing a key enzyme able to convert locked carbohydrates to fermentable sugars. Key enzymes can be provided by transgenic plants or plant parts, transgenic microbes, transgenic yeast, microbes or yeast. | 2011-08-18 |
20110201060 | PROCESS FOR THE PREPARATION OF SCYLLO-INOSITOL - This invention pertains to a process for manufacturing scyllo-Inositol. Specifically, the current invention pertains to a process for converting myo-Inositol to scyllo-Inositol using a bioconversion process. | 2011-08-18 |
20110201061 | Process For Hydrolysis Of Wet Fiber And Method For Producing Fermentation Products From Wet Fiber - Disclosed are a method of hydrolysis of wet fiber and a method for preparing ethanol. Generally, an agricultural plant material, such as corn hulls, distiller's dried grains, or spent germ, is treated to at least partially hydrolyze the fiber. The process may include a maceration step followed by a shearing operation in the presence of steam to yield a treated product, in which, in many embodiments, saccharides will be released and unbound from fibrous portions of the agricultural product. In some embodiments, the process includes macerating the material to provide a slurry having a solids content of at least 10 percent and jet cooking the slurry. A mixture of saccharides prepared in this fashion may be fermented to yield ethanol and/or biochemicals. | 2011-08-18 |
20110201062 | BACTERIUM CAPABLE OF PRODUCING L-AMINO ACID AND METHOD FOR PRODUCING L-AMINO ACID - A bacterium is described which belongs to the Enterobacteriaceae family, and has an ability to produce an L-amino acid, such as L-glutamic acid, L-arginine and L-threonine. The bacterium is modified so that the activity of a protein encoded by ydcl gene is decreased, thereby producing and accumulating the L-amino acid selected from L-glutamic acid, L-arginine, and L-threonine in the culture medium or cells of the bacterium when cultured in a culture medium. Subsequently, the L-amino acid is collected from the culture medium or the bacterium. | 2011-08-18 |
20110201063 | Algae growth for biofuels - A method and apparatus of algal oil production including the steps of: control growing to provide intensive growth to supply starting means for algae farming; Farming algae from using primarily sunlight Processing algae from the farmed algae preferably using a wet extraction process: and wherein at least one of the steps includes use of a bag able to be interconnected to gas or liquid flows of at least one of water, CO | 2011-08-18 |
20110201064 | CONVERSION TO BIOENERGY FROM BIOMASS OF PROTISTAN GRAZERS FEEDING ON AQUATIC PLANT AND/OR ALGAE WHICH CAN SURVIVE AND UPTAKE GREENHOUSE GASES IN THE MIXTURE OF TOXIC GASES AND SUBSTANCE - Provided are a method for removing and/or absorbing greenhouse gases using aquatic plant and/or algae having a greenhouse gas absorbing performance and resistance to toxic substances, a method for producing bioenergy using predators with high fatty acids, and a method for producing bioenergy including cultivating aquatic plant and/or algae having a greenhouse gas absorbing performance and resistance to toxic substances, while supplying a waste gas mixture to the aquatic plant and/or algae, (S2) cultivating predators having a capability to prey on the aquatic plant and/or algae while supplying the aquatic plant and/or algae to the predators, (S3) harvesting the predators, and (S4) converting the harvested predators into bioenergy. | 2011-08-18 |
20110201065 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS - The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | 2011-08-18 |
20110201066 | PRODUCTION OF FATTY ACID ALKYL ESTERS BY USE OF TWO LIPOLYTIC ENZYMES - A method for producing fatty acid alkyl esters, wherein a solution comprising triglyceride and alcohol is contacted with a first lipolytic enzyme having a relatively higher activity on free fatty acids than on triglyceride and a second lipolytic enzyme having a relatively higher activity on triglyceride than on free fatty acids. | 2011-08-18 |
20110201067 | METHOD FOR PREPARING POLYLACTATE AND COPOLYMER THEREOF USING A MUTANT MICROORGANISM WITH ENHANCED POLYLACTATE, AND THE COPOLYMER PRODUCING CAPABILITY THEREOF - Provided is a method of preparing polylactate (PLA) or a copolymer thereof using a mutant microorganism in which a gene participating in a coenzyme A (CoA) donor- and lactate-producing pathway is genetically manipulated to increase the productivity of a CoA donor and lactate. Amounts of the CoA donor and the lactate are simultaneously increased in a microbial metabolic pathway to enable effective biosynthesis of PLA and a hydroxyalkanoate-lactate copolymer having a high content of lactate, which is industrially useful. | 2011-08-18 |
20110201068 | MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ISOPROPANOL WITH PRIMARY ALCOHOLS, DIOLS AND ACIDS - The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13-BDO) and isopropanol pathways or methylacrylic acid (MAA) and isopropanolpathways. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in each of the respective n-propanol, 14-BDO, 13-BDO or MAA and isopropanol pathways. The invention additionally provides a method for co-producing n-propanol and isopropanol, 14-BDO and isopropanol, 13-BDO and isopropanol or MAA and isopropanol. The method can include culturing an n-propanol and an isopropanol co-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an n-propanol, an isopropanol, a 14-BDO, a 13-BDO and/or a MAA pathway enzyme in a sufficient amount to produce each of the respective products, under conditions and for a sufficient period of time to produce each of the respective products. | 2011-08-18 |
20110201069 | Method for Producing Oligomer and/or Monomer by Degrading Biodegradable Resin - An object of the present invention is to provide a method for efficiently producing an oligomer or a monomer by degrading a biodegradable resin using an enzyme, so that the oligomer or the monomer can be recovered. | 2011-08-18 |
20110201070 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 1,2-PROPANEDIOL AND ACETOL - The present invention concerns a modified microorganism with an increased methylglyoxal reductase activity, and its use for the preparation of 1,2-propanediol and/or acetol. In particular this increased methylglyoxal reductase activity is obtained by increasing the expression of specific genes from microorganisms. | 2011-08-18 |
20110201071 | Methods and organisms for the growth-coupled production of 1,4-Butanediol - The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO. | 2011-08-18 |
20110201072 | Modified alcohol dehydrogenases for the production of fuels and chemicals - The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 2011-08-18 |
20110201073 | Reduced by-product accumulation for improved production of isobutanol - The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 2011-08-18 |
20110201074 | THERMOPHILIC MICRO-ORGANISMS FOR ETHANOL PRODUCTION - A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene. | 2011-08-18 |
20110201075 | OPTOINJECTION METHODS - Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation. | 2011-08-18 |
20110201076 | HARVESTING MICRO ALGAE - A reusable composite paramagnetic particle may comprise a paramagnetic core encased by a protective material to which is grafted a tendril layer comprising a plurality of polymeric chains. The polymeric chains may be designed to interact with a microorganism. The interaction between the microorganism and the polymeric chain may be electrostatic. The nanoparticle may be used in a method to isolate or recover microorganisms from solutions using an externally applied magnetic field. | 2011-08-18 |
20110201077 | COMPOSITION, METHOD, AND KIT FOR PREPARING PLASMIN - A streptokinase immobilized on a surface, in particular an immobilized plasmin-resistant streptokinase, and compositions, methods and kits of utilizing same for preparing plasmin are provided. | 2011-08-18 |
20110201078 | LIGAND FUNCTIONALIZED POLYMERS - Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed. | 2011-08-18 |
20110201079 | IDENTIFICATION AND MODIFICATION OF DYNAMICAL REGIONS IN PROTEINS FOR ALTERATION OF ENZYME CATALYTIC EFFECT - A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in chemical, biochemical, pharmaceutical, and other purposes. The method identifies key protein vibration modes that control the chemical reaction rate of the protein-mediated reaction, providing identification of the factors that enable the enzymes to achieve the high rate of reaction enhancement. By controlling these factors, the function of enzymes may be modulated, i.e., the activity can either be increased for faster enzyme reaction or it can be decreased when a slower enzyme is desired. This method provides an inexpensive and efficient solution by utilizing computer simulations, in combination with available experimental data, to build suitable models and investigate the enzyme activity. | 2011-08-18 |
20110201080 | BIOMOLECULES HAVING MULTIPLE ATTACHMENT MOIETIES FOR BINDING TO A SUBSTRATE SURFACE - Compounds relating to attachment chemistries for binding biomolecules to a substrate surface are described. These include compounds of the following structure: | 2011-08-18 |
20110201081 | Buttiauxella Sp. Phytase Variants - Provided herein are variants of | 2011-08-18 |
20110201082 | POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 2011-08-18 |
20110201083 | PRODUCTION OF C5-C8 ALCOHOLS USING EVOLVED ENZYMES AND METABOLICALLY ENGINEERED MICROORGANISMS - Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing higher alcohols including C5-C8 alcohol from a suitable substrate. | 2011-08-18 |
20110201084 | ENZYMATIC HYDROLYSIS OF CELLULOSIC BIOMASS THROUGH ENHANCED REMOVAL OF OLIGOMERS - The methods and composition of the disclosure are directed to the reducing cellulase inhibition by xylooligomers through adding hemicellulase enzymes that break xylooligomers down to monomeric sugars with a corresponding increase in glucose release. What was heretofore unknown is that xylobiose and higher xylooligomers inhibit enzymatic hydrolysis of any lignocellulosic biomass (plant material) used as feed stocks for commercial ethanol production, including, but not limited to, corn stover, birch wood, switchgrass, poplar wood, Miscanthus, aspen, other grasses and woody plants, and many other types of agricultural and forestry residues, as well as municipal solid waste. In addition, the examples herein show that xylobiose and xylotriose have progressively greater effects on hydrolysis rates. In accordance with the disclosure, the addition of one or more hemicellulase enzymes, such as xylanase and β-xylosidase, to a lignocellulosic biomass significantly improves hydrolysis performance. | 2011-08-18 |
20110201085 | NUCLEIC ACID EXTRACTION FROM COMPLEX MATRICES - The present disclosure describes an adsorbent and exemplary protocols for extracting nucleic acids, such as DNA and RNA, from complex matrices, such as stool samples and water samples. The adsorbent is activated charcoal coated with a material such as polyvinylpyrrolidone, dextran, or coconut flours. The adsorbent may be used in microcentrifuge spin columns, where it may be present as a slurry in a storage solution. The sample may be prepared by vortexing in a buffer solution, centrifuging, adding a protease to the supernatant, and passing the supernatant through a microcentrifuge spin column containing coated activated charcoal. The key components, including buffer, protease, and spin columns, may be packaged in a kit. | 2011-08-18 |
20110201086 | METHOD FOR PRODUCING RECOMBINANT VIRUS - To provide a method for producing, at high purity, a recombinant baculovirus which exhibits intended immunogenicity and is useful for a pharmaceutical (e.g., a vaccine), a transfer vector for use in the production of the recombinant baculovirus, and a method for producing the transfer vector. The method for producing a transfer vector which includes therein a fusion gene containing at least one gene encoding a virus-particle-forming protein and a gene encoding a foreign immunogenic protein, the method including modifying the polynucleotide sequence of the gene encoding the virus-particle-forming protein so as not to alter the amino acid residues constituting a corresponding naturally occurring virus-particle-forming protein and/or modifying the polynucleotide sequence of the gene so that a portion of the amino acid residues constituting the naturally occurring virus-particle-forming protein is deleted. | 2011-08-18 |
20110201087 | Compositions and Methods for the Production of Alpha-Herpesviruses - The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media. | 2011-08-18 |
20110201088 | Production of rAAV in Vero Cells Using Particular Adenovirus Helpers - The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, in some embodiments the invention contemplates the use of an adenovirus known as Simian Adenovirus 13 (SAdV-13) and Vero cells for production of recombinant adeno-associated virus (rAAV). | 2011-08-18 |
20110201089 | METHODS FOR INCREASING PRODUCT YIELDS - A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product. | 2011-08-18 |
20110201090 | Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids - The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 2011-08-18 |
20110201091 | Production of microbial growth stimulant with ammonia fiber explosion (AFEX) pretreatment and cellulose hydrolysis - A process for producing a microbial growth stimulant (MGS) from a plant biomass is described. An ammonium hydroxide solution is used to extract a solution of proteins and ammonia from the biomass. Some of the proteins and ammonia are separated from the extracted solution to provide the MGS solution. The removed ammonia can be recycled and the proteins are useful as animal feeds. | 2011-08-18 |
20110201092 | LISTERIA ATTENUATED FOR ENTRY INTO NON-PHAGOCYTIC CELLS, VACCINES COMPRISING THE LISTERIA, AND METHODS OF USE THEREOF - The present invention provides | 2011-08-18 |
20110201093 | GLUCOSE CONVERSION TO ETHANOL VIA YEAST CULTURES AND BICARBONATE IONS - The present invention is directed to the enhanced production of ethanol from fermentation using an ethanol producing microorganism. In particular, the present invention provides a process for the enhanced growth and metabolism of an ethanol producing microorganism (e.g., yeast), for the purpose of increasing or enhancing ethanol production, both in terms of total ethanol produced and in terms of the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products (i.e., ethanol). In accordance with this invention bicarbonate ions are used to enhance ethanol fermentation and/or reduce the time required for ethanol producing microorganisms to convert carbohydrates and/or sugars to end products, i.e., ethanol. The present invention can also be used for enhancing fermentation end products in, for example, the fuel ethanol, industrial, cheese, brewing, and wine making industries. | 2011-08-18 |
20110201094 | Methods And Compositions For Growth Of Hydrocarbons In Botryococcus sp. - Acceleration of botryococcenoids and growth by concomitant provision of appropriate light, minerals, and assimilable carbon. Specifically, methods, compositions and systems for the in vitro growth of hydrocarbons in photosynthetic organisms while maintaining a biologically exclusive monocultural environment, as for example, from | 2011-08-18 |
20110201095 | Method of Treating a Sulphide Mineral - A copper bioleaching process which makes use of a consortium which contains | 2011-08-18 |
20110201096 | METHOD FOR DIGESTING A BIOMASS COMPRISING LIGNIN TOGETHER WITH CELLULOSE AND/OR HEMICELLULOSE - The invention relates to a method for digesting a biomass comprising, lignin, cellulose, and hemicellulose, comprising the steps of: (a) contacting the biomass with a first solvent for dissolving the cellulose and/or the hemicellulose, (b) contacting the dissolved cellulose and/or hemicellulose with a precipitant for forming a precipitate comprising cellulose and/or hemicellulose and residual lignin, wherein the precipitant is selected from the group consisting of alkanes, ethers, and esters; and (c) contacting the precipitate with a second solvent for removing residual lignin from the precipitate. The invention further relates to an apparatus for performing such a method. | 2011-08-18 |
20110201097 | Ionic Liquid Apparatus and Method for Biological Samples - Apparatus and method for handling biological samples. Segments of ionic liquid can provide voltage across segments of immiscible liquid to concentrate or separate charged species in the biological samples. Reactants in biological samples can be contacted and reacted in segments of immiscible liquid. | 2011-08-18 |
20110201098 | Polymer Replicated Interdigitated Electrode Array for Bio(Sensing) Applications - A sensor is disclosed. In one embodiment, the sensor includes an insulating substrate comprising a first zone, a second zone, and an intermediate zone, where the intermediate zone comprises a portion of the second zone that overlaps the first zone. The sensor further comprises a first electrode in the first zone that comprises a first plurality of fingers of a conductive material, a second electrode in the second zone that comprises a second plurality of fingers of the conductive material that are interdigitated with the first plurality of fingers, a plurality of three-dimensional isolation structures, and a plurality of shadow zones, wherein each shadow zone is adjacent to at least one isolation structure and is substantially free of conductive material. The plurality of isolation structures may comprises hills and/or channels. | 2011-08-18 |
20110201099 | Assay Cartridges and Methods of Using the Same - Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge. | 2011-08-18 |
20110201100 | SINGLE USE CELL CULTURE BIOREACTOR MANIFOLD SYSTEM - The invention provides a disposable cell culture bioreactor manifold system for use in coupling sensors, fluid samplers, conduits, and the like, to a cell culture bioreactor in a sterile manner. The disposable bioreactor manifold system includes an externally attachable bioreactor manifold connector body for fluidly attaching modular sensor arrangements that measure physical variables and other parameters of medium contained within a bioreactor, as well as medium sampling components, and other connections, as well as at least one conduit fluidly connecting connecting the bioreactor manifold connector body with a pump for pumping fluids between the bioreactor and the bioreactor manifold connector body. | 2011-08-18 |
20110201101 | CENTRIFUGAL FORCE-BASED MICROFLUIDIC DEVICE FOR PROTEIN DETECTION AND MICROFLUIDIC SYSTEM INCLUDING THE SAME - Disclosed is a microfluidic structure and a microfluidic device comprising the microfluidic device, which is suitable for detecting a target material. The microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction. | 2011-08-18 |
20110201102 | Method and apparatus for cultivating organisms - A bioreactor for growing organisms such as microalgae, includes a container having a parabolic cross section for carrying a culture medium for the organism. A generally triangular flow director in the bottom center of the container with a tube at its top end contains openings for directing fluid such as a growth medium under pressure upwardly into the culture medium to create laminar flow of the culture medium in counter rotating paths of travel on opposite sides of the flow director. Thus, thorough mixing of the culture medium and organism is achieved. | 2011-08-18 |
20110201103 | System For Synergetic Expression Of Multiple Small Functional RNA Elements - The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNA families and clusters capable of targeting multiple oncogenic pathways. | 2011-08-18 |
20110201104 | ANTIVIRAL AGENT AGAINST ANIMAL VIRUSES - Disclosed herein is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active ingredient, the protein having binding ability and degrading ability to foreign nucleic acid chains invaded in an animal cell and that has no cytotoxicity to the animal cell itself. Disclosed herein is further an antiviral animal cell containing the protein according to the present invention, or the nucleic acid sequence encoding the protein. The antiviral agent and antiviral animal cell exhibit advantageous effects in that they selectively degrade foreign nucleic acid chains invaded in an animal cell and have no cytotoxicity to the animal cell, thus causing no death of the animal cell. | 2011-08-18 |
20110201105 | LACTATION-ASSOCIATED POLYPEPTIDES - The invention relates to cDNA libraries obtained from Tammar wallaby ( | 2011-08-18 |
20110201106 | DEVICES AND METHODS FOR TISSUE HANDLING AND EMBEDDING - A mould and tissue cassette for automated embedding of tissue, and a method of operation are disclosed. The mould attaches to the cassette prior to embedding, and fits into a rack. The rack supports the mould holding the tissue cassette when the mould and cassette are in a first position. When the mould and cassette are moved to a second position, a projection on the rack separates the mould from the cassette, to facilitate easy removal. Also disclosed is a mould for a tissue cassette having projections for holding the mould to a rack, so that the tissue cassette is not in contact with the mould. | 2011-08-18 |
20110201107 | Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals - Novel double and triple fusion reporter gene constructs harboring distinct imagable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies. | 2011-08-18 |
20110201108 | ISOLATED MYELOID-LIKE BONE MARROW CELL POPULATIONS AND METHODS OF TREATMENT THEREWITH - The present invention provides an isolated myeloid-like bone marrow cell population comprising a majority of cells that are lineage negative, and which express both CD44 antigen and CD11b antigen. These cells have beneficial vasculotrophic and neurotrophic activity when intraocularly administered to the eye of a mammal, particularly a mammal suffering from an ocular degenerative disease. The myeloid-like bone marrow cells are isolated by treating bone marrow cells with an antibody against CD44 (hyaluronic acid receptor), against CD11b, or against both and using flow cytometry to positively select CD44 and/or CD11b expressing cells therefrom. The isolated myeloid-like bone marrow cells of the invention can be transfected with a gene encoding a therapeutically useful protein, for delivering the gene to the retina. | 2011-08-18 |
20110201109 | Ronin is Essential for Perpetuity of Mouse ES Cells, and Acts Independently of Canonical Pathways - The present invention, therefore, encompasses compositions and methods comprising Ronin, a Ronin activator, and methods of their use for maintaining the perpetuity of an ES cell phenotype. | 2011-08-18 |
20110201110 | EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3 or 4 factors can be improved dramatically. Additionally, dental pulp stem cells are easily available because they can be isolated and prepared from extracted wisdom teeth and teeth extracted because of periodontal disease and the like, so that they can be used widely as a source of somatic cells for iPS cell banks. | 2011-08-18 |
20110201111 | METHOD FOR OBTAINING CONNECTIVE MESENCHYMAL STEM CELLS FROM THE MONONUCLEAR FRACTION OF HUMAN BONE MARROW - The present invention relates to a method for obtaining connective mesenchymal stem cells from the mononuclear fraction of human bone marrow cells using type AB human serum as a supplement. Said method includes the steps of obtaining said mononuclear fraction of bone marrow, the step of recovering and pre-expanding the connective stem cells and the step of expanding the connective stem cells until obtaining the clinical dose required for the therapeutic use thereof. | 2011-08-18 |
20110201112 | Vault Complexes for Facilitating Biomolecule Delivery - The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject. | 2011-08-18 |
20110201113 | Ex Vivo Progenitor and Stem Cell Expansion and Differentiation for Use in the Treatment of Disease of the Nervous System - The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders, | 2011-08-18 |
20110201114 | Manufacturing Method of Immune Killer Cells - The present invention relates to a manufacturing method of immune killer cells characterized in that an immune killer cell is induced in a culture medium containing concanavalin A (ConA), and the immune killer cell is maintained or expanded in a culture procedure. Antibody proteins are not used as a stimulant in the culture process to avoid the risk of being infected by zoonotic diseases and effectively increase the number and specific release of the immune killer cells. | 2011-08-18 |
20110201115 | METHOD AND APPARATUS FOR PRODUCTION OF A SKIN GRAFT AND THE GRAFT PRODUCED THEREBY - A micro-organ structure comprising at least two micro-organ portions formed from a tissue, in which said at lest two micro-organs are linked one to the other by means of a junction formed from said tissue of which the micro-organs were formed therefrom. | 2011-08-18 |
20110201116 | TEST METHOD USING CELLS AND TEST KIT THEREFOR - The present invention provides a method for performing a biological test under conditions in which an artificially prepared cell pattern with initial position coordinates that can be determined is three-dimensionally cultured within a gelled matrix. The present invention relates to a biological test method that comprises testing a biological indicator with reference to at least one selected from the group consisting of cell proliferation, cell movement, and cell differentiation in a cell pattern substantially embedded in gel. The present invention also relates to a kit for the biological test method. | 2011-08-18 |
20110201117 | FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES - Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores. | 2011-08-18 |
20110201118 | NUCLEASE ACTIVITY OF TAL EFFECTOR AND FOKI FUSION PROTEIN - The present invention provides compositions and methods for targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector binding domain and a cleavage domain. The cleavage domain can be from any endonuclease. In certain embodiments, the endonuclease is a Type IIS restriction endonuclease. In further embodiments, the Type IIS restriction endonuclease is FokI. | 2011-08-18 |
20110201119 | ALPHAVIRUS PACKAGING CELL LINES - This invention provides alphavirus packaging cell lines useful for commercial production of recombinant alphavirus particles and structural protein expression cassettes for making the packaging cell lines. | 2011-08-18 |
20110201120 | METHOD FOR INTRODUCING GENE INTO CELL, AND COMPOSITION FOR USE IN THE METHOD - The present invention provides a method for transferring a gene into cells, which is practically useful and can achieve high transfer efficiency, and also a composition for use in the method. By bringing a mixture of a composition comprising a diallylamine sulfur dioxide copolymer having a repeating unit represented by the formula (1) or a salt thereof and a gene into contact with a cell, a gene such as DNA and RNA can be transferred into a target cell safely and conveniently, and into a cell at a specific site with high gene transfer efficiency. | 2011-08-18 |
20110201121 | METHOD OF TESTING A LIQUID SAMPLE, A TEST UNIT, AND AN AUTOMATIZED SYSTEM OF A PLURALITY OF TEST UNITS - A method of testing a liquid sample, a test unit, an and automatized system of a plurality of test units. The system is for large scale testing patient blood samples, comprising a large number of test units at different locations and connected through a common control unit. In an individual test unit there is a liquid dosing chamber, hermetically closed packages of calibrator and control liquids, closed liquid reagent packages, a liquid sample inlet and an actuator for dosing and mixing the reacting components and elements for registering results from the reactions. The test unit can calibrate, control and test reactions automatically under surveillance of the control unit. The system can use the same packaged liquids in each of the test units, enabling calculation of averages of the control results and, through comparison of individual results with an average, letting faults be detected through results outside permitted deviations. | 2011-08-18 |
20110201122 | HYPERGLYCOSYLATED hCG DETECTION DEVICE - The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a second, different material. At least one of the release medium and the capture medium includes a binding member that exhibits a moderate to high affinity for hCG-H and is selectively or preferentially reactive with hCG-H. | 2011-08-18 |
20110201123 | LOW COST, HIGH ACCURACY OZONE SENSING - An ozone detection system includes a source of sample gas containing a concentration of ozone and a single optical pathway. The system includes a light source in optical communication with the optical pathway. The system further includes a first airflow passageway for receiving a first sample of gas from the source. The passageway includes a catalytic scrubber to reduce ozone content in the sample gas and passing the reduced ozone gas to a sensor. The system further includes a second airflow passageway for receiving a second sample of gas from the source and passing the gas unaltered to a sensor. The system further includes a sensor for sensing independently the light intensity of the sample of gas received from the first and second passageways. The system further includes a processor for receiving the light intensity data from the sensor and calculating the ozone concentration in the source of sample gas. | 2011-08-18 |
20110201124 | OZONE REDUCING Y-PIPE FOR LOW COST OZONE SENSOR - An ozone detection system includes a source of sample gas containing a concentration of ozone. The system further includes a first airflow passageway for receiving a first sample of gas from the source. The first airflow passageway includes a catalytic scrubber to reduce ozone content in the sample gas and a second airflow passageway receives a second sample of gas from the source. A third airflow passageway results from the convergence of the first and second airflow passageways wherein the reduced sample gas and the unaltered sample gas are combined to form a diluted sample gas. A sensor is provided for sensing the ozone concentration in the diluted sample gas received from the third airflow passageway. A processor is provided operative to calculate the actual concentration of ozone in the sample gas as a function of the sensed concentration of the diluted sample. | 2011-08-18 |
20110201125 | METHODS AND RELATED DEVICES FOR CONTINUOUS SENSING UTILIZING MAGNETIC BEADS - A fluidic device including a main channel, wherein a first inlet fluidly connects to an upstream end of the main channel and introduces magnetic beads into a first side of the main channel A second inlet is fluidly connected to the upstream end of the main channel and introduces a sample stream into a second side of the main channel A first magnet disposed adjacent to the second side of the main channel pulls the magnetic beads towards a sidewall of the second side, and thus into the sample stream A second magnet disposed downstream from the first magnet and adjacent to a first side of the main channel subsequently pulls the magnetic beads towards a sidewall of the first side, and thus out of the sample stream A detection region is disposed at or downstream from the second magnet and in the first side of the main channel | 2011-08-18 |
20110201126 | INTERFACE TO A MASS SPECTROMETER - An interface is provided for coupling a sample source, including a TOC/TN analyzer to an isotope detector, including an isotope ratio mass spectrometer. The interface comprises a sample conduit having an inlet for fluid connection with the sample source and an outlet for fluid connection with the isotope detector. A sample trap is fluidly connected in the sample conduit. A helium bypass conduit is has an inlet for fluid connection with a helium supply line and an outlet for fluid connection with the sample conduit. The interface traps the target sample while contaminants are exhausted. The sample is released from the sample trap and is carried to the isotope detector on a stream of helium. Effluent contaminants are not held in the interface. There is no significant fouling of the interface or contamination of samples carried to the isotope detector. | 2011-08-18 |
20110201127 | INDEPENDENT HEATING OF SAMPLES IN A SAMPLE HOLDER - There is described a heating system for independently heating at least one sample recipient containing a sample, the sample recipient provided in a sample holder, comprising: a heating chamber having at least one opening and adapted to receive the sample holder; at least one microwave generator for generating microwaves; at least one microwave applicator inside the heating chamber connected to the at least one microwave generator, the at least one microwave applicator comprising an oven cavity portion for creating a mini microwave cavity around a single sample recipient in the sample holder, and for applying microwaves generated by the at least one microwave generator directly to the single sample recipient; and a control unit for controlling the at least one microwave generator. | 2011-08-18 |
20110201128 | BLOOD MARKERS OF TRANSPLANTED INTESTINE REJECTION - The present invention relates to a method for detecting bowel transplant rejection. | 2011-08-18 |
20110201129 | METHOD FOR THE DETECTION OF ENDOMETRIOSIS USING AN ME-2 ANTIGEN - A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to SEQ ID NO: 6 polypeptide or a truncated peptide comprising an epitope of SEQ ID NO: 6 in a sample from the subject; and comparing the test amount with a normal range of the antibody in a control sample from a subject who does not suffer from endometriosis, whereby a test amount above the normal range provides a positive indication in the diagnosis of endometriosis. | 2011-08-18 |
20110201130 | HUMAN B-TYPE NATRIURETIC PEPTIDE ASSAY HAVING REDUCED CROSS-REACTIVITY WITH OTHER PEPTIDE FORMS - The present disclosure provides among other things assays, methods and kits for assessing the presence or amount of human B-type natriuretic peptide in a test sample wherein the assay exhibits reduced cross-reactivity with other forms of the peptide. | 2011-08-18 |
20110201131 | ANTIBODY DETECTION METHOD INVOLVING OLIGONUCLEOTIDE ENHANCED COLLOIDAL GOLD SIGNAL - The present invention refers to a rapid immunochromatographic test device for antibody detection, comprising at least a first and a second conjugate releasing pad, wherein the first conjugate pad comprises a gold conjugated protein linked first oligonucleotide and a gold conjugated anti-antibody, and the second conjugate pad comprises a gold conjugated protein linked second oligonucleotide, which second oligonucleotide is complementary to the first oligonucleotide. The present invention further refers to a use of such test device for antibody detection in urine or saliva, e.g. HIV antibody. Embodiments of the test device are a test strip and a detection cup. The present invention also refers to a method for manufacturing such test device. | 2011-08-18 |
20110201132 | Optical Detection of Label-Free Biomolecular Interactions using Microreplicated Plastic - Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. | 2011-08-18 |