33rd week of 2011 patent applcation highlights part 37 |
Patent application number | Title | Published |
20110200932 | RAISED LETTER PRINTING USING LARGE YELLOW TONER PARTICLES - Electrophotographic printing of one or more layers of toner to enable the printing of a wide range of toner mass laydown using electrophotography to produce prints with raised letters. This method encompasses the steps of forming multicolor toner images and fusing the print one or more times to create the raised print. having the desired height of raised print. | 2011-08-18 |
20110200933 | RAISED PRINTING USING SMALL TONER PARTICLES - Electrophotographic printing of one or more layers of toner to enable the printing of a wide range of toner mass laydown using electrophotography to produce prints with raised letters. This method encompasses the steps of forming multicolor toner images and fusing the print one or more times to create the raised print having the desired height of raised print. | 2011-08-18 |
20110200934 | METHOD OF PRODUCING HEAT-SENSITIVE TRANSFER IMAGE-RECEIVING SHEET HAVING A LENTICULAR LENS - A method of producing a heat-sensitive transfer image-receiving sheet, having the steps of: conveying a transparent support by web handling; providing at least one receptor layer on the transparent support; and drying the heat-sensitive transfer image-receiving sheet, in which the at least one receptor layer contains a latex polymer having a weighted average glass transition temperature of 30° C. or more, the heat-sensitive transfer image-receiving sheet is dried at a temperature that is higher than the weighted average glass transition temperature by 30° C. or more, and the heat-sensitive transfer image-receiving sheet has a lenticular lens on the side of the transparent support opposite to the side on which the receptor layer is provided. | 2011-08-18 |
20110200935 | PHOTORESIST COMPOSITION - The present invention provides a photoresist composition having a sulfonium salt comprising an anion represented by the formula (IA): | 2011-08-18 |
20110200936 | SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME - A salt represented by the formula (I): | 2011-08-18 |
20110200937 | POSITIVE PHOTOSENSITIVE RESIN COMPOSITION FOR SPRAY COATING AND METHOD FOR PRODUCING THROUGH ELECTRODE USING THE SAME - The present invention provides a positive photosensitive resin composition for spray coating, which comprises an alkali-soluble resin, a compound which generates an acid when exposed to light and a solvent, and which has a viscosity of 0.5 to 200 cP. By using the positive photosensitive resin composition, it is possible to form a coating film having a uniform thickness on the inner surface of a hole having a high aspect ratio. By using a coating film pattern, which is obtained by exposing and developing a predetermined region of the obtained coating film, as an insulating film or mask for forming an insulating film pattern, it is possible to suppress generation of leakage current in a hole and to form a through electrode with a high yield. | 2011-08-18 |
20110200938 | Antireflective Compositions and Methods of Using Same - A novel antireflective coating composition is provided, said antireflective coating composition comprising a) a compound of formula 1, b) a thermal acid generator, (c) at least one polymer, | 2011-08-18 |
20110200939 | POLYAMIC ACID, POLYIMIDE, PHOTOSENSITIVE RESIN COMPOSITION COMPRISING THE SAME AND DRY FILM MANUFACTURED BY THE SAME - The present invention relates to a polyamic acid or polyimide comprising a heat-polymerizable or photo-polymerizable functional group, a photosensitive resin composition comprising the polyamic acid or the polyimide, a photosensitive resin composition being capable of providing a cured film that can be used for patterning at a high resolution and that has an excellent developing property in an alkaline aqueous solution, flexibility, adhesion strength, resistance to welding heat, and pressure cooker test (PCT) resistance, and a dry film prepared from the composition. | 2011-08-18 |
20110200940 | SALT AND PHOTORESIST COMPOSITION COMPRISING THE SAME - The present invention provides a salt represented by the formula (I): | 2011-08-18 |
20110200941 | CHEMICALLY AMPLIFIED POSITIVE RESIST COMPOSITION FOR EB OR EUV LITHOGRAPHY AND PATTERNING PROCESS - A chemically amplified positive resist composition for EB or EUV lithography is provided comprising (A) a polymer or a blend of polymers wherein a film of the polymer or polymer blend is insoluble in alkaline developer, but turns soluble under the action of acid, (B) an acid generator, (C) a basic compound, and (D) a solvent. The basic compound (C) is a polymer comprising recurring units bearing a side chain having a secondary or tertiary amine structure as a basic active site and constitutes a part or the entirety of the polymer or polymers as component (A). | 2011-08-18 |
20110200942 | CHEMICALLY AMPLIFIED NEGATIVE RESIST COMPOSITION FOR EB OR EUV LITHOGRAPHY AND PATTERNING PROCESS - A chemically amplified negative resist composition is provided comprising (A) an alkali-soluble polymer, (B) an acid generator, and (C) a nitrogen-containing compound as a basic component, the polymer (A) turning alkali insoluble under the catalysis of acid. A basic polymer having a secondary or tertiary amine structure on a side chain serves as components (A) and (C). Processing the negative resist composition by EB or EUV lithography process may form a fine size resist pattern with advantages including uniform diffusion of base, improved LER, controlled deactivation of acid at the substrate interface, and a reduced degree of undercut. | 2011-08-18 |
20110200943 | METHOD FOR PRODUCING A PLANOGRAPHIC PRINTING PLATE - Provided is a method of producing a planographic printing plate, including: subjecting a planographic printing plate precursor, which has a support and a positive-working image recording layer, to image-wise exposure; and developing it using an alkaline aqueous solution which contains a specific compound and has a pH of from 8.5 to 10.8, in this order. The recording layer has: a lower layer containing a water-insoluble and alkali-soluble resin and an infrared ray absorbing agent; and an upper layer containing a water-insoluble and alkali-soluble polyurethane resin and a polyorganosiloxane. The specific compound is a nonionic or anionic surfactant, or at least one compound represented by Formula (1) or (2), wherein R | 2011-08-18 |
20110200944 | MANUFACTURING METHOD OF EXPOSURE APPARATUS AND DEVICE MANUFACTURING METHOD - A manufacturing method of an exposure apparatus includes adjusting a positioning device that determines a positional relation at the time of docking between a body and a stage module such that a positional relation between an absolute reference surface of a metrology frame of the body and a stage position reference surface of the stage module becomes a desired relation. Accordingly, after that, only by docking the body and the stage module with each other via the positioning device, the positional relation between the absolute reference surface of the body and the stage position reference surface of the stage module becomes a desired relation. | 2011-08-18 |
20110200945 | METHOD OF MANUFACTURING FLAT PANEL DISPLAY - An alignment mark having high precision and good visibility is formed in a simple manner without modification of a manufacturing line or a significant increase of man hours and a flat panel display is manufactured at low cost and with good productivity. To achieve this, the method includes a step of forming a photosensitive film on a substrate, a step of forming an alignment mark by exposing the photosensitive film by using an exposing mask, and a step of performing position alignment by recognizing the alignment mark in an undeveloped state of the photosensitive film. | 2011-08-18 |
20110200946 | MICROLITHOGRAPHY PROJECTION EXPOSURE APPARATUS HAVING AT LEAST TWO OPERATING STATES - A microlithography projection exposure apparatus for producing microelectronic components has at least two operating states. The microlithography projection exposure apparatus includes a reflective mask in an object plane. In the first operating state, a first partial region of the mask is illuminated by a first radiation, which has an assigned first centroid direction having a first centroid direction vector at each point of the first partial region. In the second operating state, a second partial region of the mask is illuminated by a second radiation, which has an assigned second centroid direction having a second centroid direction vector at each point of the second partial region. The first and the second partial region have a common overlap region. Furthermore, the microlithography projection exposure apparatus can be configured in such a way that at each point of at least one partial region of the overlap region the scalar triple product of the normalized first centroid direction vector, the normalized second centroid direction vector and a normalized vector that is perpendicular to the mask is less than 0.05. | 2011-08-18 |
20110200947 | PATTERNING METHOD - A method of patterning a dielectric layer with a Zep 520 positive EB photoresist as a mask, comprising the steps of depositing an α-Si film on the dielectric layer; providing a layer of Zep 520 positive EB photoresist having high-resolution patterns therein by electron beam direct writing; etching the α-Si film by chlorine-based plasma with the layer of Zep 520 positive EB photoresist as a mask, so as to transfer the high-resolution patterns of the Zep 520 positive EB photoresist to the underlying α-Si film; removing the Zep 520 positive EB photoresist; etching the dielectric layer by fluorine-based plasma with the α-Si film having high-fidelity patterns as a hard mask, so as to provide patterns of recesses; and removing the α-Si film by wet etching or dry etching. The inventive method is completely compatible with and easily incorporated into the conventional CMOS processes, with high reliability and resolution for providing nanoscale fine patterns of recesses. It solves the above-mentioned problem in the fabrication of novel structure of CMOS device. | 2011-08-18 |
20110200948 | Method of Fabricating Micro-Devices - A new and novel method utilizing current nano-technological processes for fabricating a range of micro-devices with significantly expanded capabilities, unique functionalities at microscopic levels, enhanced degree of flexibilities, reduced costs and improved performance in the fields of bioscience and medicine is disclosed in the within patent application. Micro-devices fabricated using the disclosed nano-technological techniques have significant improvements in many areas over the existing, conventional methods. Such improvements include, but are not limited to reduced overall costs, early disease detection, targeted drug delivery, targeted disease treatment and reduced degree of invasiveness in treatment. Compared with existing, conventional approaches, the said inventive approach disclosed in this patent application is much more microscopic, sensitive, accurate, precise, flexible and effective. This novel approach is able to deliver a superior level of performance in medical treatments over the existing modalities. | 2011-08-18 |
20110200949 | SUBSTRATE PROCESSING METHOD - A substrate processing method includes a first process (step S | 2011-08-18 |
20110200950 | PHOTOCURABLE COMPOSITION - A method for the preparation of a photocurable resin by a reaction comprising the following steps i) reacting a mixture of a novolak type epoxy resin (A) and a dicyclopentadiene-phenol glycidylether resin (B) with ii) an advancement component (C) containing at least 2 phenolic hydroxyl groups per molecule; iii) reacting with an unsaturated monocarboxylic acid (D); and iv) esterification of the unsaturated group containing resin obtained from the steps of i) to iii) with a polycarboxylic acid anhydride or a carboxylic acid anhydride (E) is disclosed. | 2011-08-18 |
20110200951 | METHOD FOR REMOVING PHOTORESIST PATTERN - Disclosed is a method of removing a photoresist pattern, which includes radiating light onto a substrate having a photoresist pattern formed thereon and implanted with a predetermined dopant so that the temperature of the substrate is increased to be equal to or higher than a temperature able to remove the photoresist pattern, and by which the photoresist pattern formed on the substrate can be almost completely removed using a simple process for radiating light onto the substrate so that the temperature of the substrate is increased to be equal to or higher than a temperature able to the photoresist pattern. | 2011-08-18 |
20110200952 | DEVELOPING APPARATUS, DEVELOPING METHOD AND STORAGE MEDIUM - There is provided a developing apparatus and a developing method capable of rapidly forming a liquid film of a developing solution on an entire surface of a substrate while reducing a usage amount of the developing solution. The developing apparatus includes an airtightly sealed processing vessel that forms a processing atmosphere therein; a temperature control plate that is provided within the processing vessel and mounts the substrate thereon; an atmosphere gas supply unit that supplies an atmosphere gas including mist and vapor of a developing solution onto a surface of the substrate within the processing vessel; and a first temperature control unit that controls the temperature control plate to a temperature allowing the atmosphere gas to be condensed on the substrate. Here, an inner wall of the processing vessel is maintained at a temperature at which the atmosphere gas is hardly condensed on the inner wall. | 2011-08-18 |
20110200953 | DEVELOPING APPARATUS, DEVELOPING METHOD AND STORAGE MEDIUM - There is provided a developing apparatus capable of achieving high throughput. The developing apparatus includes an airtightly sealed processing vessel that forms a processing atmosphere therein; an atmosphere gas supply unit that supplies an atmosphere gas containing mist of a developing solution into the processing vessel in order to form a liquid film of the developing solution on a surface of a substrate loaded into the processing vessel; and a drying unit that dries the substrate in order to stop a developing process by the liquid film. A reaction between a resist and the developing solution can be stopped. Therefore, a developing process can be performed in parallel with a cleaning process performed by a cleaning module and high throughput is achieved. | 2011-08-18 |
20110200954 | RENEWABLE ENERGY MICROGENERATION SYSTEM - A renewable energy microgeneration system is disclosed. The system includes a portable processing container with a mixing tank for mixing waste with a liquid, a macerating pump in fluid communication with the mixing tank that is configured to macerate the waste into smaller pieces, a plurality of small holding tanks in fluid communication with the mixing tank that are configured to perform at least one of a pasteurization thermophilic anaerobic digestion on the waste, a large holding tank in fluid communication with the plurality of small holding tanks that is configured to perform mesophilic anaerobic digestion on the waste after at least one of a pasteurization thermophilic anaerobic digestion is performed on the waste, and a de-watering unit in fluid communication with the large holding tank that is configured to dry what remains of the waste after mesophilic anaerobic digestion is performed on the waste; a controller for automating the flow of the waste between the mixing tank, the plurality of small holding tanks, the large holding tank, and the de-watering unit such that a user does not need to complete any tasks for performing mesophilic anaerobic digestion after the waste is loaded into the mixing tank; and a portable gas storage container comprising a gas storage tank that is configured to store biogas generated by the mesophilic anaerobic digestion, wherein the portable processing container and the portable gas storage container are configured to be transported to a site and placed in fluid communication with each other so the gas storage tank can store biogas generated by mesophilic anaerobic digestion in the processing container at the site. | 2011-08-18 |
20110200955 | Liquid Fuel Combustion Process and Apparatus - An apparatus for combustion of a liquid fuel, such as an atomizer or burner, and an associated method using the apparatus for combusting an atomized liquid fuel. The apparatus for combustion has in outer conduit, an inner conduit and a spray tip. The spray tip has a mixing chamber for receiving a liquid fuel and an atomizing gas, and an orifice for discharging the liquid fuel and atomizing gas mixture as an atomized liquid fuel. The inner conduit has external fins where at least some of the external fins contact the inner surface of the spray tip. | 2011-08-18 |
20110200956 | Candle Holder - A candle holder that allows for the installed candle to be lit without having to remove the candle from the holder and that maintains the candle in an upright orientation as the orientation of the candle holder is varied. The candle holder includes a housing fixedly connected to an enclosure, the housing comprising, in one embodiment, a counterbalance with an annular top adapted to receive the candle. The present invention is also a candle holder with a pivotally connected candle tray that slides out of the housing to access the candle. | 2011-08-18 |
20110200957 | METHOD AND DEVICE FOR HEATING A ROTATABLY MOUNTED GUIDE CASING OF A GUIDE ROLLER - The invention relates to a method and a device for heating rotatably mounted guide casing of a guide roller for guiding and heating threads. The guide roller has a guide casing which is held on the circumference of an axle support by means of an air bearing. To heat the guide casing, compressed air is heated outside the guide roller and supplied to the air bearing within the guide roller. | 2011-08-18 |
20110200958 | Hot Blast Stove Dome and Hot Blast Stove - A hot blast stove dome comprises a first dome portion adapted for support on a combustion chamber wall of a hot blast stove, and a second dome portion adapted for support on a checker chamber wall of a hot blast stove, wherein a vertical expansion joint is provided between the first dome portion and the second dome portion and is adapted to allow the first dome portion and the second dome portion to independently accommodate vertical expansion of their respective supporting walls. The dome is suitably provided in a hot blast stove which comprises a combustion chamber, a checker chamber, a cylindrical housing comprising a combustion chamber wall and a checker chamber wall. | 2011-08-18 |
20110200959 | ELECTROMAGNETIC RADIATION EMITTING TOOTHBRUSH AND DENTIFRICE SYSTEM - A device includes a handle coupled with an activated textured surface that can be implemented using a repetitive movement mechanism and a treatment energy source, such as an electromagnetic radiation source. The handle may be used to provide detection, treatment and/or management of sundry conditions including, for example, tooth discoloration, tissue damage, periodontal disease, tumors, pain, halitosis, and bronchitis. The activated textured surface may include a surface topography including corrugations, bristles, protuberances, or pits, or other surfaces for facilitating agitation, cleaning or other surface treatments. | 2011-08-18 |
20110200960 | THERAPEUTIC TOOTH BUD ABLATION - An ablation procedure. The ablation procedure may be applied to tooth buds | 2011-08-18 |
20110200961 | THERAPEUTIC TOOTH BUD ABLATION - An ablation procedure. The ablation procedure may be applied to tooth buds | 2011-08-18 |
20110200962 | Improved Dental Model Baseplate - A dental model baseplate for use in the manufacture of a working dental model. The baseplate includes a connector element to fix a dental model articulator. An apparatus includes a plate portion and an adapter portion extending from the plate portion, the adapter portion configured for connecting to a portion of the dental articulator. | 2011-08-18 |
20110200963 | Dental Element For Abrading Dental Composite Resin - An abrading dental floss is characterized by dental floss formed of a circular fiber or fibrous material having a dental abrasive on the exterior portion thereof suitable for polishing, sanding and/or finishing (abrading) dental restorative material particularly dental composite resin. The dental abrading material is impregnated into or provided onto the dental floss. In one form, the dental abrading floss has an abrading section situated between lengths of non-abrading dental floss. The abrading section may be formed of an alternating pattern of non-abrasive portions and abrasive portions along a length of the floss. The abrasive portions may be of a single grit or texture of the dental abrasive or may be of different grits of the dental abrasive. In another form, the dental abrading floss has a single grit of a dental abrasive along and about its entire length. The dental abrasive may be of a single grit or different grits of the dental abrasive along its length. For different grits of the dental abrasive, it is preferred, but not necessary, that they gradually change in grit size. | 2011-08-18 |
20110200964 | STAINLESS STEEL BUR - A stainless steel bur, which can cut minute depressions etc. and even healthy dentin when necessary, allowing a technician to detect when cutting the healthy dentin is provided. It includes a removable handle ( | 2011-08-18 |
20110200965 | Dental Attachment Quality Testing Device - The invention relates to a method and apparatus for testing attachment quality of a dental crown attached to a tooth and/or implant. The method comprises the steps of: detecting at least one resonance frequency of a member when it is in contact with said crown or a part attached to the crown; and interpreting the detected resonance frequency in terms of the degree of attachment of the crown to a tooth. | 2011-08-18 |
20110200966 | Machining of Ceramic Materials - Milling strategies for machining dental ceramic materials are provided that reduce milling time while maintaining strength, accuracy and marginal integrity. | 2011-08-18 |
20110200967 | DENTAL HEALING ABUTMENT - A dental healing abutment assembly having a tubular holder and a plurality of removable nestable shells. Each nestable shell has a proximal end and a distal end open to permit the nesting of the shell with the holder or other nestable shells. The proximal end of each nestable shell is defined by a base plate. The tubular holder and the nestable shells each have a pass through hole for accommodating a mounting member. The healing abutment assembly is attached to a dental implant impacted in a patient's jawbone by way of the mounting member. | 2011-08-18 |
20110200968 | SYSTEM AND METHOD FOR FABRICATING A DENTAL HEALING ABUTMENT - A dental healing abutment assembly having a tubular holder and a plurality of removable nestable shells. Each nestable shell has a proximal end and a distal end open to permit the nesting of the shell with the holder or other nestable shells. The proximal end of each nestable shell is defined by a base plate. The tubular holder and the nestable shells each have a pass through hole for accommodating a mounting member. The healing abutment assembly is attached to a dental implant impacted in a patient's jawbone by way of the mounting member. Furthermore, a system and method are provided for fabricating a permanent abutment by decoding an identifier disposed on the healing abutment. | 2011-08-18 |
20110200969 | Band of Connective Tissue Grooves for Use with a Dental Implant or a Separate Abutment for a Dental Implant - The present invention is a dental implant system that has a band of connective tissue rings and grooves on an external surface of the dental implant system. The connective tissue band grooves have a depth of from greater than about 25 μm to about 600 μm. The dental implant system is designed to minimize tissue loss and to reduce the risk of bacterial infection in the implant site. | 2011-08-18 |
20110200970 | METHODS FOR PLACING AN IMPLANT ANALOG IN A PHYSICAL MODEL OF THE PATIENT'S MOUTH - A method of placing a dental implant analog in a physical model for use in creating a dental prosthesis is provided. The physical model, which is usually based on an impression of the patient's mouth or a scan of the patient's mouth, is prepared. The model is scanned. A three-dimensional computer model of the physical model is created and is used to develop the location of the dental implant. A robot then modifies the physical model to create an opening for the implant analog. The robot then places the implant analog within the opening at the location dictated by the three-dimensional computer model. | 2011-08-18 |
20110200971 | Dental Compositions with Fluorescent Pigment - The invention features a dental composition containing a fluorescent organic pigment, e.g. a hydroxyl substituted aryl guanamine an or a fluorescent compound encapsulated in a thermo plastic or thermo set polymer, in an amount that provides the composition with fluorescence resembling that of natural teeth. | 2011-08-18 |
20110200972 | ORAL CARE AND DELIVERY DEVICE - A device for providing oral care. The device is formed to have surface features for delivery of medication or other compositions to the mouth, the throat, the gums and the cheeks. Blisters or cavities are formed on a surface of the device to contain and deliver a material, such as mouthwash or medicine, into the various areas of the mouth of the user, and may be formed to provide a time-controlled release of the deliverable material. | 2011-08-18 |
20110200973 | Light- and Dual-Cure Dental Resins and Adhesives With Increased Cure and Color Stability and Low Color - Various embodiments of the present invention generally relate to a light-cure and dual-cure resin that have low color and is color stable over conventional light, self and dual-cured resins. Additionally, the light-cure resin has enhanced degree of cure over conventional light-cure resins. Finally, due to the low color and enhanced color stability of the dual-cure resins, their inherent property of having lower shrinkage stress as compared to light-cure resins can now be utilized in various dental applications and other resin applications. | 2011-08-18 |
20110200974 | AIR RESCUE SIMULATOR - An air rescue simulator, wherein the simulator comprises a helicopter passenger cabin, which is attached to a crane system. | 2011-08-18 |
20110200975 | Educational Game for Teaching Addition and Subtraction of Whole Numbers - An educational game for teaching addition and subtraction of whole numbers includes a carpet/game board including ten positively numbered spaces from +1 to +10 inclusive a 0 space and negatively numbered spaces from −1 to −10 inclusive and wherein said positive numbered spaces proceed upwardly in a generally zigzag direction from 0 to plus 10 and the negatively numbered spaces proceed downwardly from 0 to minus 10 and an extra space above the plus 10 and an extra space below the minus 10 wherein the extra space above the plus 10 is a win space and the space below the minus 10 is a lose space. The game also includes a single cube shaped die having six faces with an indication of plus 2, minus 2 and no movement on three of the faces and a plus 1, minus 1 and plus 1 plus and additional turn on the sixth face. Further, the game includes six game pieces of separate distinct colors. | 2011-08-18 |
20110200976 | METHOD AND APPARATUS FOR IN VITRO TESTING FOR MEDICAL DEVICES - Apparatus for simulating a female vagina includes a pressure chamber, a vaginal model disposed in a pressure chamber and means to deliver liquid into the vaginal model. The pressure chamber includes an interior, first means to provide fluid pressure to the pressure chamber, and second means to provide localized fluid pressure within the pressure chamber. The vaginal model includes a wall that (1) defines a vaginal lumen extending inwardly from a vaginal opening associated with a bore through an exterior surface of the pressure chamber to vaginal fornices adjacent a cervical port; (2) has an outer surface comprising an anterior vaginal surface and a posterior vaginal surface; and (3) has at least one passage for providing a fluid to the cervical port. Methods for using this apparatus are also disclosed. | 2011-08-18 |
20110200977 | Cannulation simulator - A cannulation simulator. The simulator comprises a frame ( | 2011-08-18 |
20110200978 | ONLINE INSTRUCTIONAL DIALOG BOOKS - A computer implemented instructional management system enables educators to organize and integrate Internet-based or other digital content with planning, assessment, and intervention information. Interactive instructional dialog files, or simply “dialogs,” offer a flexible alternative to traditional printed textbooks in the education environment. Dialogs are assembled into a larger electronic, interactive instructional content presentation, or “Dialog Book.” Thus dialog books are comprised of instructional resource content comprising individual instructional dialogs aligned to standards for inclusion in a book chapter; and links to websites, and various other digital media content. Flexible online creation and editing of dialog books supports dynamically (a) Aligning instructional materials directly to pacing calendars; (b) Adapting instructional materials to accommodate changing educational standards and advances in knowledge within the educational materials; (c) Constructing intervention portfolios that document intervention implementation and outcomes; and other benefits. These resources can be shared electronically across classrooms, teachers, districts and even states. | 2011-08-18 |
20110200979 | Online instructional dialogs - A system of online communications among students and the teacher (“Dialogs”) within an educational management system, includes dialogs comprised of integration of online interactions between students and teachers, to be included in K-12 curriculum. Interactions may include lesson plans, assignments, benchmark and formative assessments. The system provides a permanent record of instruction indicating what has been taught and learned, and providing actionable information that can inform future instruction. The system has the ability to record the extent to which intervention has been implemented. Manual and automated scheduling of online interactions provide for real-time and asynchronous communications, and the ability to suspend interactions prior to completion. | 2011-08-18 |
20110200980 | INFORMATION PROCESSING DEVICE OPERATION CONTROL SYSTEM AND OPERATION CONTROL METHOD - Provided is an information processing device operation control system which records an operation history of a function module; analyzes the operation history; extracts a reserved function module; references tutorial information according to the extracted reserved function module; acquires a tutorial of the reserved function module; adds to schedule information, the type of the plan content based on the position information, the time information, and the use example contained in the tutorial information, as a user plan; and reports the use example of a plurality of function modules according to the schedule information, so as to start a tutorial. | 2011-08-18 |
20110200981 | Polymerized Hemoglobin Media And Its Use In Isolation And Transplantation of Islet Cells - Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes. | 2011-08-18 |
20110200982 | GENETICALLY MODIFIED MICE AND ENGRAFTMENT - A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., | 2011-08-18 |
20110200983 | METHODS AND MATERIALS FOR DETECTING VIRAL OR MICROBIAL INFECTIONS - This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target nucleic acid, kits for detecting the amount of target nucleic acid present within a sample, and methods for making such kits are provided. | 2011-08-18 |
20110200984 | USING NUCLEIC ACIDS FOR CLINICAL MICROBIOLOGY TESTING - A process for analysing a biological sample, comprising the steps of: (a) identifying a micro-organism present within the sample; and (b) determining the effect of one or more antimicrobial(s) on a micro-organism from the sample, wherein steps (a) and (b) are performed by analysing the micro-organism's nucleic acid. Steps (a) and (b) will generally occur in that order, but they may take place concurrently. The steps may advantageously be performed within a single apparatus. Conveniently, the nucleic acid analyte used for step (a) is the same as that used in step (b) e.g. the same PCR amplicon. A micro-organism's nucleic acids can thus be used both to identify the presence of the micro-organism within a sample and then to assess the effect of antimicrobials on its growth. | 2011-08-18 |
20110200985 | COMPOSITIONS FOR USE IN IDENTIFICATION OF HERPESVIRUSES - The present invention relates generally to identification of herpesviruses and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis. | 2011-08-18 |
20110200986 | BIO-ASSAY USING LIQUID CRYSTALS - There is provided a method, an in vitro method and a detection system for detecting the presence of at least one biological molecule in at least one sample. The method can include, for example, providing a sample and/or a binding agent to a contact portion of a surface by way of at least one microfluidic channel; disposing a liquid crystal at the contact portion; determining whether the orientation of the liquid crystal changes after the sample contacts the binding agent, indicating the presence of the biological molecule; and determining length of bright region of the liquid crystal and/or change in interference color of said liquid crystal, and consequently indicating the quantity of said biological molecule. Also disclosed are methods of detecting biological molecules using at least one 4′-pentyl-biphenyl-4-R, where R may be at least one functional group selected from carboxylic acid, amine, aldehyde, and oligopeptide. | 2011-08-18 |
20110200987 | COMPOSITIONS AND METHODS FOR MODIFYING CELLULAR PROPERTIES - The invention generally provides compositions and methods for modulating cell properties and enhancing recombinant protein yields. In particular, the compositions and methods provide for cells having altered growth characteristics, including altered adhesion, rate of proliferation, growth to particular cell density, and recombinant protein expression level. | 2011-08-18 |
20110200988 | 3'-OH unblocked uncleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA squencing - Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker to a non-cleavable terminating group. The non-cleavable-fluorescent group is designed to terminate DNA synthesis so that DNA oligomers can be sequenced efficiently in a parallel format. These reagents and methods will lead to more accurate identification of polymorphisms and other valuable genetic information. | 2011-08-18 |
20110200989 | SINGLE MOLECULE NUCLEIC ACID SEQUENCING USING MULTIPHOTON FLUORESCENCE EXCITATION - A system for detection of nucleic acids can include an excitation source configured to transmit excitation energy to a reaction site including a single molecule of nucleic acid reacted with a two-photon absorption moiety. The system also can include an optical system configured to focus the excitation energy transmitted from the excitation source to a focal region containing the reaction site, wherein said excitation energy within the focal region is sufficient to cause two-photon absorption by the two-photon absorption moiety. The system can further include a detector configured to detect emissions generated at the reaction site resulting from two-photon absorption of the excitation energy by the two-photon absorption moiety. | 2011-08-18 |
20110200990 | RECEPTOR ACTIVATOR OF NF kappa-B - Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof. | 2011-08-18 |
20110200991 | AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE - A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases. | 2011-08-18 |
20110200992 | Biological Compositions, Articles and Methods for Monitoring Sterilization Processes - A sterility indicating composition comprising a plurality of sterilization process resistant spores; a germination medium comprising a sub-lethal amount of at least one cell-permeant nucleic acid-interacting fluorescent dye and at least one nutrient for germination of the spores; wherein the at least one cell-permeant fluorescent dye can interact with nucleic acids present in and produced by the plurality of spores during germination or during germination and outgrowth of the spores to produce an increase in fluorescence intensity, indicating that viable spores are present, and wherein the cell-permeant fluorescent dye is sufficiently stable at least at a temperature for incubating the spores to produce the increase in fluorescence intensity, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed. | 2011-08-18 |
20110200993 | NEW TREATMENT OF AUTOIMMUNE CONDITIONS - The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in identifying agent suitable for the prophylaxis, prevention and/or treatment of an autoimmune condition. The invention further relates to methods and materials involved in diagnosing autoimmune diseases like arthritis, multiple sclerosis and inflammatory bowels disease accompanied by decreased cellular uptake of amino acids caused by defects in cellular amino acid transporters like Slc38A1 (Solute carrier family 38, member 1). The invention also relates to methods and materials involved in diagnosing, treating, preventing, or delaying the onset and ameliorating the symptoms of autoimmune conditions that are accompanied by defects in cellular amino acid transporters. | 2011-08-18 |
20110200994 | Method for Diagnosing a Genetic Predisposition for Vascular Disease - The invention relates to a method for diagnosing a genetic predisposition for a vascular disease, in particular for a coronary artery disease (CAD). According to the invention, the method has the following steps: Providing a sample containing a nucleic acid derived from the gene GCH1; and determining the presence or absence of a nucleotide polymorphism (SNP) of the gene GCH1 in the nucleic acid, wherein the SNP is selected from the group consisting of rs8007267 G>A, rs3783641 A>T, and rs10483639 C>G, wherein the presence of at least one of said SNPs indicates a genetic predisposition for a vascular disease. | 2011-08-18 |
20110200995 | OPTIMIZED PROBES AND PRIMERS AND METHODS OF USING SAME FOR THE DETECTION, SCREENING, ISOLATION AND SEQUENCING OF VANCOMYCIN RESISTANCE GENES AND VANCOMYCIN RESISTANT ENTEROCOCCI - Described herein are primers and probes useful for detecting, screening, isolating, and sequencing of the vancomycin resistance genes and vancomycin resistant Enterococci and methods of using the described primers and probes. | 2011-08-18 |
20110200996 | COMPOSITIONS AND METHODS FOR DETECTION OF COLORECTAL CANCER - We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery. | 2011-08-18 |
20110200997 | COMPOSITIONS FOR USE IN IDENTIFICATION OF ENTERIC BACTERIAL PATHOGENS - The present invention relates generally to identification of enteric bacterial pathogens, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis. | 2011-08-18 |
20110200998 | Prognosis and Therapy Predictive Markers and Methods of Use - Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods of the invention. | 2011-08-18 |
20110200999 | NOVEL DEVICE AND METHOD FOR RAPID DETECTION OF MICROORGANISMS - The present invention is directed to a platform technology for quick and easy detection and identification of single or multiple microorganisms in a sample using peptide labeled oligonucleotides (PLONs). The PLONs are specifically designed to be complementary to certain nucleic acid sequences on a target microorganism. When the PLONs of the present invention are added to nucleic acids extracted from a sample (both biological and/or non-biological), they hybridize to the specific target nucleic acids of the microorganisms, and the PLONs are then detected with one or more specific enzymes coupled to antibodies that are specific to the conjugated peptides attached to the PLONs. The hybridized PLON-enzyme coupled antibody complex is further localized to a test region on a solid matrix or support by the presence of a composition comprising a secondary antibody to enzyme coupled antibody and provides a specific, sensitive, easy to use tool for the detection and identification that does not require any amplification step and any equipment for the final read out. A kit and methods of use of the invention are also provided. | 2011-08-18 |
20110201000 | METHODS AND MATERIALS FOR DETECTING GENETIC OR EPIGENETIC ELEMENTS - This document provides methods and materials for detecting genetic and/or epigenetic elements. For example, methods and materials for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, methods and materials for detecting the amount of target nucleic acid containing a genetic or epigenetic element within a sample, kits for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, kits for detecting the amount of target nucleic acid containing a genetic or epigenetic element present within a sample, and methods for making such kits are provided. | 2011-08-18 |
20110201001 | METHODS AND MATERIALS FOR ASSESSING RNA EXPRESSION - This document provides methods and materials for assessing RNA expression. For example, methods and materials for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), kits for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), and methods for making such kits are provided. | 2011-08-18 |
20110201002 | 2'-Terminator Nucleotide-Related Methods and Systems - The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media. | 2011-08-18 |
20110201003 | METHOD FOR OBTAINING PURKINJE PROGENITOR CELL BY USING NEPH3(65B13) AND E-CADHERIN - 65B13 was discovered to be a useful marker for isolating GABA neuron progenitor cells including Purkinje cells. Furthermore, E-cadherin was revealed to be a useful marker for isolating Purkinje progenitor cells from a 65B13-positive cell population. Specifically, when used in combination with 65B13, E-cadherin was found to be a useful marker for isolating Purkinje progenitor cells. | 2011-08-18 |
20110201004 | Digital Amplification - The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules can be isolated by dilution and individually amplified; each product is then separately analyzed for the presence of pre-defined mutations. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample. | 2011-08-18 |
20110201005 | Methods and Nucleic Acids for the Detection of Metastasis of Colon Cell Proliferative Disorders - The invention provides methods, nucleic acids and kits for detecting metastasis of colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of metastasis of colon cell proliferative disorders, thereby enabling the improved diagnosis and treatment of patients. | 2011-08-18 |
20110201006 | Oligonucleotide Detection Method - The invention relates to a method for the detection of oligonucleotides using anion exchange high performance liquid chromatography. Fluorescently labelled peptide nucleic acid oligomers, complementary to the oligonucleotide are hybridized to the oligonucleotides. Anion exchange high performance liquid chromatography is then performed and the hybridized moieties detected and quantitated. The invention also relates to a method for the simultaneous detection of both strands of an oligonucleotide in parallel from one sample, and a kit for use in qualitative and quantitative detection of one or two strands of an oligonucleotide | 2011-08-18 |
20110201007 | DIAGNOSTIC TEST FOR STREPTOCOCCUS EQUI - The invention relates generally to methods and materials concerning diseases caused by | 2011-08-18 |
20110201008 | ASSAYS, METHODS AND KITS FOR MEASURING RESPONSE TO THERAPY AND PREDICTING CLINICAL OUTCOME IN PATIENTS WITH B-CELL LYMPHOMA - Assays, methods and kits for predicting survival outcome in a subject having diffuse large B-cell lymphoma (DLBCL) and for measuring a subject's response to DLBCL therapy involve specific miRNAs that are prognostic biomarkers for prediction of outcome of DLBCL patients. Expression of miRNAs miR-18a, miR-181a and miR-222 is associated with response to therapy and outcome of patients with DLBCL. Measurement of these miRs can be used to identify patients' outcomes in the clinic and allow tailoring of patient-specific therapy. | 2011-08-18 |
20110201009 | Microfabricated Crossflow Devices and Methods - A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for high throughput screening, e.g. combinatorial screening. The microfluidic device comprises a main channel and an inlet region in communication with the main channel at a droplet extrusion region. Droplets of solution containing the biological material are deposited into the main channel through the droplet extrusion region. A fluid different from and incompatible with the solution containing the biological material flows through the main channel so that the droplets containing the biological material do not diffuse or mix. Biological material within the droplets can be analyzed and/or sorted by detecting a predetermined characteristic of the biological sample in each droplet and sorting the droplet accordingly. | 2011-08-18 |
20110201010 | COMPOSITIONS AND METHODS FOR THE PROTECTION OF NUCLEOPHILIC GROUPS - The present invention provides compositions, methods, and kits relating to the protection and deprotection of molecules comprising nucleophilic groups, such as the protection and deprotection of thermostable polymerases. Also provided are methods of performing nucleic acid amplification using polymerases protected according to the invention. | 2011-08-18 |
20110201011 | METHODS FOR ASSAYING MC1R VARIANTS AND MITOCHONDRIAL MARKERS IN SKIN SAMPLES - The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 2011-08-18 |
20110201012 | METHODS AND COMPOSITIONS FOR DIAGNOSING EPITHELIAL CELL CANCER - Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers. | 2011-08-18 |
20110201013 | Assays and Devices For Identifying Pathogens - Provided are methods and devices for identifying pathogens based on protein translation from ribosomes isolated from the pathogens. | 2011-08-18 |
20110201014 | ANTIBODY BINDING TO ENVELOPE PROTEIN 2 OF HEPATITIS C VIRUS AND METHOD FOR IDENTIFYING GENOTYPE OF HEPATITIS C VIRUS USING THE SAME - The present invention provides an antibody that specifically binds to envelope protein 2 of HCV of genotype 2a but does not immunologically react with envelope protein 2 of HCV of genotype 1a. | 2011-08-18 |
20110201015 | METHOD FOR MEASURING ENDOTOXIN AND REAGENT KIT FOR MEASURING ENDOTOXIN - A technique which is less likely to be affected by turbid or color of samples and with which prompt and simple detection or concentration measurement of endotoxin can be achieved is provided. A reagent in which proteins contained in LAL are adsorbed or bound onto fine particles dispersed in a previously prepared drug liquid is prepared, and this reagent and a sample containing endotoxin are mixed. By doing this, endotoxin acts on the proteins on the fine particles and the fine particles are associated with one another to form a large aggregate at an early stage. By optically measuring the formation of this aggregate, detection or concentration measurement of endotoxin is performed. | 2011-08-18 |
20110201016 | METHOD FOR DETECTING MODULATOR FOR REGULATING ACTIVITY OF CELLULAR COMPONENT IN CELL - A method for detecting a modulator that can regulate biological and/or physiological activity of a cellular component is provided. The method can detect a modulator, after determining whether there is a competitive reaction between a reference substance and a modulator toward the cellular component in a cell by imaging a magnetic pattern magnetized in a direction of a magnetic line of force and a pattern of a label bound to the cellular component. The method has a benefit that since the reaction of a cellular component with a reference substance and a modulator such as a drug occurs in a cell, the competition reaction between the reference substance and the modulator toward the cellular component can reflect the real metabolism occurred in a live cell. It can also allow the result of interaction between the cellular component and the modulator such as a drug to be visualized and to be identified directly in a live cell. Additionally, the method has advantages to screen many modulators using a few reference substances and to detect the functions of the modulator in a cell, e.g., its efficacy without modifying the modulator by introducing the reference substance. | 2011-08-18 |
20110201017 | LUPUS ANTICOAGULENT TESTING - The present invention relates generally to the field of diagnostic screening and diagnostic assays. In particular, the present invention provides an improved, rapid, and efficient method of screening for antiphospholipid antibodies, such as lupus anticoagulants (LA). The invention also relates to a kit for screening plasma levels for antiphospholipid antibodies in subjects in need thereof, such as those at risk for or suffering from, inter alia, antiphospholipid syndrome (APS) and systemic lupus erythromatosus (SLE). | 2011-08-18 |
20110201018 | METHODS AND COMPOSITIONS FOR RISK STRATIFICATION - The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations. | 2011-08-18 |
20110201019 | Methods and Compositions for Detecting Receptor-Ligand Interactions in Single Cells - The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state. | 2011-08-18 |
20110201020 | T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS - The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. | 2011-08-18 |
20110201021 | USE OF THE IRAP PROTEIN FOR IMPLEMENTING METHODS OF DIAGNOSIS AND OF PROGNOSIS - The use of the IRAP protein for implementing methods of diagnosis and of prognosis. | 2011-08-18 |
20110201022 | ASSAYS FOR DETECTION OF PHENYLALANINE AMMONIA-LYASE AND ANTIBODIES TO PHENYLALANINE AMMONIA-LYASE - Provided herein are methods of detecting the presence of a pegylated enzyme, an enzyme-specific antibody (e.g., a neutralizing antibody or of a particular isotype), or a polyethylene glycol (PEG)-specific antibody in a sample, such as a bodily fluid or tissue of a patient. In certain embodiments, the enzyme is phenylalanine ammonia-lyase (PAL), such as | 2011-08-18 |
20110201023 | MANNOSE 6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES - The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. Finally, the invention relates to the use of an antibody or antibody fragment of the invention for use in medicine, in particular for the diagnosis of a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. | 2011-08-18 |
20110201024 | COMPOSITIONS COMPRISING A DEHALOGENASE SUBSTRATE AND A FLUORESCENT LABEL AND METHODS OF USE - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 2011-08-18 |
20110201025 | Polymer-coupled peptidases - The present invention is directed to a simple process for the modification of the specificity of a peptidase of the hemostatic system by coupling polymers to the peptidase causing it to lose its reactivity in the hemostatic system, but enabling it to continue to react with certain inhibitors, effectors and substrates. The invention is furthermore directed to processes for the detection or quantitative determination of inhibitors of the peptidase in bodily fluids or other samples as well as to processes for their neutralization and/or removal from liquids. Finally, the invention allows the use of a polymer-coupled peptidase as drug and furthermore provides a device which makes use of such a peptidase in the removal of peptidase inhibitors from samples or from the bloodstream of a patient. | 2011-08-18 |
20110201026 | COMPOSITIONS AND METHODS FOR THE DETECTION OF ANTIBODIES TO NATIVE HUMAN LEUKOCYTE ANTIGEN - Provided herein are compositions comprising native and denatured human leukocyte antigens (HLA) and methods of making said compositions. Also provided herein are methods and kits for the detection of antibodies to native HLAs. | 2011-08-18 |
20110201027 | BIOSENSOR FOR DETECTING A TRACE AMOUNT OF SAMPLE AND PRODUCTION METHOD THEREFOR - The present invention relates to a biosensor capable of a trace amount of sample and a fabrication method thereof. More specifically, the invention relates to a method for fabricating a biosensor, the method comprising: immobilizing a receptor molecule, which binds selectively to a target substance, on an electrically insulated nano-electrode chip; binding an enzyme to the receptor molecule; and treating the bound enzyme with metal ions and depositing the metal ions on the nano-electrode surface, and to a biosensor fabricated thereby. According to the invention, a precipitate is produced on the nano-electrode surface by a precipitation between the enzyme and the metal ions, and the produced precipitate electrically connects the nano-electrodes together, thereby increasing electrical conductivity. Thus, the invention is useful for quantitative analysis of trace amounts and/or various concentrations of target substances. | 2011-08-18 |
20110201028 | T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS - The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. | 2011-08-18 |
20110201029 | IL-13 RECEPTOR ANTIBODIES - This invention relates to monoclonal and polyclonal antibodies capable of specifically recognizing IL-13 receptor α and uses thereof. | 2011-08-18 |
20110201030 | Human G-Protein Chemokine Receptor (CCR5) HDGNR10 - Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. | 2011-08-18 |
20110201031 | PREPARATION METHOD - A method of performing an immunologic evaluation of a subject, comprising collecting a whole blood sample from the subject, maintaining the sample for at least 6 hours after collection, purifying a population of cells comprising lymphocytes and antigen presenting cells from the maintained sample, optionally by a process incorporating a positive or negative affinity selection step to remove granulocytes, and using the purified cells in a cell-mediated immunoassay (CMI assay). | 2011-08-18 |