33rd week of 2009 patent applcation highlights part 37 |
Patent application number | Title | Published |
20090202924 | METHOD OF EVALUATING A PHOTO MASK AND METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE - A method of evaluating a photo mask, includes measuring each dimension of a plurality of pattern portions of a mask pattern formed on a photo mask, obtaining an inter-pattern distance between the pattern portion and a pattern different from the pattern portion with respect to each of the pattern portions, obtaining a dimensional difference between the measured dimension of the pattern portion and a target dimension of the pattern portion with respect to each of the pattern portions, grouping the dimensional difference obtained for each pattern portion into a plurality of groups in accordance with the inter-pattern distance obtained for each pattern portion, obtaining an evaluation value based on the dimensional difference in each group with respect to each of the groups, and evaluating the photo mask based on the evaluation value. | 2009-08-13 |
20090202925 | PHOTOMASK DEFECT CORRECTION METHOD, PHOTOMASK MANUFACTURING METHOD, PHASE SHIFT MASK MANUFACTURING METHOD, PHOTOMASK, PHASE SHIFT MASK, PHOTOMASK SET, AND PATTERN TRANSFER METHOD - A first photomask | 2009-08-13 |
20090202926 | EXPOSURE MASK AND PATTERN FORMING METHOD THEREFOR - An exposure mask is constituted of hole-patterns whose scales are higher than the limit resolution of exposure light and which are repetitively aligned in X-Y directions with the prescribed pitch (ranging from 140 nm to 180 nm) therebetween, halftone phase shift regions whose transmission factors range from 2% to 20% and each of which is aligned between two hole-patterns adjacently lying in the X-direction or the Y-direction so as to apply an inverse phase to incidence light, and light preventive regions each of which is aligned between two hole-patterns adjacently lying in an oblique direction inclined to the X-direction or Y-direction by 45°. The exposure mask is illuminated with azimuthal polarization light which is produced by a secondary light source of a zonal illumination and whose polarization direction is perpendicular to the radial direction of the secondary light source. | 2009-08-13 |
20090202927 | Charge control agent, toner, image forming method, and image forming apparatus - To provide: a charge control agent having negative chargeability, which contributes to environmental conservation and the like to an increased degree, has high performance (high charge amount, quick rise-up of charge, excellent stability with time, and high environmental stability), and has improved dispersibility; a toner for developing an electrostatic charge image containing the charge control agent; and an image forming method and an image forming apparatus each using the toner for developing an electrostatic charge image. A charge control agent for controlling a charged state of powder, characterized by including one or more units each represented by the following chemical formula (1) in a molecule. | 2009-08-13 |
20090202928 | Control of Crazing, Cracking or Crystallization of a Charge Transport Layer in a Photoconductor - Embodiments of a photoconductor for use in a printer or printer cartridge comprise an electrically conductive substrate, a charge generation layer disposed over the electrically conductive substrate, and a charge transport layer disposed over the charge generation layer, wherein the charge transport layer comprises charge transport molecules with octyl/decyl glycidyl ether (OGE) or dodecyl/ tetradecyl glycidyl ether (DGE), or combinations thereof, added to improve resistance to crazing, cracking and crystallization in the change transport layer. | 2009-08-13 |
20090202929 | ELECTROPHOGRAPHIC PHOTORECEPTOR INCLUDING DIPHENOQUINONE-BASED COMPOUNDS INCLUDING OXADIAZOLENE GROUP, AND ELECTROPHOTOGRAPHIC IMAGING APPARATUS USING THE SAME - An electrophotographic photoreceptor and an electrophotographic imaging apparatus using the same, the electrophotographic photoreceptor including a diphenoquinone including an oxadiazolene group represented by Formula 1 below as an electron transporting material in a single-layered type photosensitive layer or in a charge generating layer of a laminated type photosensitive layer: | 2009-08-13 |
20090202930 | INFRARED DYE COMPOSITION, INFRARED RAY ABSORBING INK AND ELECTROPHOTOGRAPHIC TONER - An infrared dye composition including at least: a compound (I) whose spectral absorption maximum wavelength is in a range of from 750 nm to 1,050 nm; and a compound (II) whose spectral absorption maximum wavelength is in a range of from 400 nm to 700 nm, wherein, when an absorbance of the infrared dye composition at a spectral absorption maximum wavelength in the range of from 750 nm to 1,050 urn is designated as 1, a maximum absorbance (Dmax) of the infrared dye composition in the range of from 400 nm to 700 nm is 0.5 or lower, and a ratio (Dmax/Dmin) is 10 or lower, and an infrared dye composition excellent in gray balance in the visible light region, and an infrared ray absorbing ink and an electrophotographic toner using the same are provided. | 2009-08-13 |
20090202931 | CHARGE CONTROL AGENTS FOR TONER COMPOSITIONS - The present disclosure provides polymer-ionic complexes useful as charge control agents. Such charge control agents may be utilized with toner particles to impart excellent triboelectric charging characteristics to the toner. | 2009-08-13 |
20090202932 | Medium for laser printing including optical special effect flakes - A laser toner includes optical effect taggent flakes or other structures in a binder suitable for binding particles to a substrate. Preferably the optical effect taggent structures have a substantially same shape or same indicia within the binder sized to be suitable for laser printing. After printing the flakes or structures become bonded to the substrate they are printed upon and are discernable by viewing with magnification. | 2009-08-13 |
20090202933 | YELLOW TONER - A yellow toner comprising colored resin particles containing a binder resin and a yellow colorant, wherein the yellow colorant is a compound represented by a structural formula (1): | 2009-08-13 |
20090202934 | ELECTROSTATIC IMAGE DEVELOPING TONER, TWO-COMPONENT DEVELOPER, IMAGE FORMING METHOD AND PROCESS CARTRIDGE - A toner including: toner particles which include: a colorant, a releasing agent, and a binder resin. The number average particle diameter of the toner particles is in the range of from 3.5 μm to 6.5 μm, wherein the number average particle diameter is determined by the Coulter method, the variation coefficient of the number distribution of the toner particles is in the range of 22.0 to 35.0, wherein the variation coefficient is found by dividing the standard deviation of the number distribution by the number average particle diameter, and 40% by number to 59% by number of the toner particles are 4.0 μm to 8.0 μm in diameter. | 2009-08-13 |
20090202935 | CARRIER, TWO-COMPONENT DEVELOPER CONTAINING CARRIER AND TONER, AND IMAGE FORMING METHOD - A carrier including magnetic core particles and a coating layer, wherein the coating layer is formed by applying a coating liquid containing at least colloidal silica, a condensate of alkoxysilane represented by General Formula (1) and a solvent onto the core particles; an amount of colloidal silica contained in the coating layer is less than 60% by mass; and a ratio (h/Dw) of a thickness (h) of the coating layer to a weight average particle diameter (Dw) of the carrier is more than 0.01, wherein the carrier is used in a two-component developer together with a toner produced through aqueous granulation and containing at least a colorant, a binder resin and a releasing agent, and wherein an amount of the releasing agent present in a region from a surface of the toner to a depth of 0.3 μm is less than 4% by mass as measured through FTIR-ATR spectroscopy. | 2009-08-13 |
20090202936 | HEAT REGULATED PRINTER ELEMENT, USE OF A RUBBER MATERIAL HAVING A PHASE CHANGE MATERIAL DISPERSED THEREIN, A PRINTER AND A METHOD OF PRINTING - A surface temperature of a heat regulated printer element is accurately controlled by providing at least a layer of a rubber material with a phase change material dispersed therein. A method of printing uses an image receiving intermediate carrier including at least a layer of a rubber material with a phase change material dispersed therein. | 2009-08-13 |
20090202937 | METHOD FOR PREPARING AN ELECTROPHOTOGRAPHIC PHOTORECEPTOR - A method for preparing an electrophotographic photoreceptor, includes coating an electroconductive substrate with an undercoat layer containing a blocked isocyanate compound, an oil-free alkyd resin including a hydroxyl group and basic amine; crosslinking the blocked isocyanate compound, oil-free alkyd resin including a hydroxyl group and basic amine; and coating the undercoat layer with a photosensitive layer. | 2009-08-13 |
20090202938 | METHOD OF IMPROVING SURFACE ABRASION RESISTANCE OF IMAGEABLE ELEMENTS - A computer-to-press multi-layer, positive-working imageable element has improved surface abrasion resistance from a micro-roughening of the outermost surface. This improvement is provided by spraying a solution consisting essentially of one or more dissolved organic resins in a solvent onto the outermost imageable layer of the imageable element. The one or more organic resins are soluble or dispersible in an aqueous alkaline solution and are present in the sprayed solution in an amount of at least 3 weight %. The sprayed solution is applied to deposit at least 10 mg/m | 2009-08-13 |
20090202939 | COMPOUND, POSITIVE RESIST COMPOSITION AND METHOD FOR FORMING RESIST PATTERN - Disclosed are a compound that can be used for a resist composition, a positive resist composition that includes the compound, and a method for forming a resist pattern. | 2009-08-13 |
20090202940 | Positive resist composition and patterning process using the same - The present invention provides a polymer, having a high sensitivity, a high degree of resolution, a good pattern configuration after exposure, and in addition an excellent etching resistance, suitable as a base resin for a positive resist composition, especially for a chemically amplified positive resist composition; a positive resist composition using the polymer; and a patterning process. | 2009-08-13 |
20090202941 | SILSESQUIOXANE RESIN SYSTEMS WITH BASE ADDITIVES BEARING ELECTRON-ATTRACTING FUNCTIONALITIES - Silsesquioxane-based compositions that contain (a) silsesquioxane resins that contain HSiO3/2 units and RSiO | 2009-08-13 |
20090202942 | PROCESS FOR PRODUCING PATTERNED FILM AND PHOTOSENSITIVE RESIN COMPOSITION - A process for producing a film pattern, in which a layer of photosensitive resin composition is formed on a substrate and exposed selectively through a mask to light to thereby obtain a film pattern provided on its surface with protrusions and depressions without the need to remove the layer of photosensitive resin composition at unexposed regions or exposed regions by, for example, development; and a photosensitive resin composition for use in the above process for producing a film pattern. There is provided a process for producing a patterned film, comprising the steps of preparing a photosensitive resin composition that upon light irradiation, generates an acid or a base and is hardened; coating substrate ( | 2009-08-13 |
20090202943 | POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS - A positive resist composition comprises a polymer comprising recurring units having a sulfonium salt incorporated therein as a base resin which becomes soluble in alkaline developer under the action of acid. The polymer generates a strong sulfonic acid upon exposure to high-energy radiation so as to facilitate effective scission of acid labile groups in the resist composition. | 2009-08-13 |
20090202944 | PHOTOSENSITIVE RESIN COMPOSITION, AND, PHOTOSENSITIVE ELEMENT, METHOD FOR FORMING RESIST PATTERN, METHOD FOR MANUFACTURING PRINTED WIRING BOARD AND METHOD FOR MANUFACTURING PARTITION WALL FOR PLASMA DISPLAY PANEL USING THE COMPOSITION - A photosensitive resin composition comprising (A) a binder polymer, (B) a photopolymerizing compound with a polymerizable ethylenic unsaturated bond, (C) a photoradical polymerization initiator containing a 2,4,5-triarylimidazole dimer or its derivative, and (D) a compound represented by the following general formula (1) | 2009-08-13 |
20090202945 | FLUORINE-CONTAINING POLYMER, PURIFICATION METHOD, AND RADIATION-SENSITIVE RESIN COMPOSITION - An object of the present invention is to provide a novel fluorine-containing polymer, a radiation-sensitive resin composition for liquid immersion lithography which contains the fluorine-containing polymer, which leads to a pattern having an excellent shape and excellent depth of focus, wherein the amount of an eluted component in a liquid for liquid immersion lithography such as water that comes in contact with the resist during exposure in liquid immersion lithography is little, and which provides a larger receding contact angle between the resist film and the liquid for liquid immersion lithography such as water, and a method for purifying the fluorine-containing polymer. The present resin composition comprises a novel fluorine-containing polymer (A) containing repeating units represented by the general formulae (1) and (2) and having Mw of 1,000-50,000, a resin (B) having an acid-unstable group, a radiation-sensitive acid generator (C), a nitrogen-containing compound (D) and a solvent (E). | 2009-08-13 |
20090202946 | POSITIVE RESIST COMPOSITION FOR USE WITH ELECTRON BEAM, X-RAY OR EUV AND PATTERN FORMING METHOD USING THE SAME - A positive resist composition for use with electron beam, X-ray or EUV and a pattern forming method using the positive resist composition are provided, the positive resist composition including: (A) a resin capable of decomposing under an action of an acid to increase a dissolution rate in an aqueous alkali solution; (B) a compound capable of generating an acid upon irradiation with actinic rays or radiation; (C) a basic compound; and (D) an organic solvent, wherein the entire solid content concentration in the resist composition is from 1.0 to 4.5 mass % and a ratio of (B) the compound capable of generating an acid upon irradiation with actinic rays or radiation is from 10 to 50 mass % based on the entire solid content. | 2009-08-13 |
20090202947 | Positive resist composition and patterning process using the same - The present invention provides a polymer suitable as a base resin for a positive resist composition, especially for a chemically amplified positive resist composition, having a high sensitivity, a high degree of resolution, a good pattern configuration after exposure, and in addition an excellent etching resistance; a positive resist composition using the polymer; and a patterning process. | 2009-08-13 |
20090202948 | METHOD FOR DEVELOPING AND SEALING OF LITHOGRAPHIC PRINTING PLATES - A method is described for producing an imaged lithographic printing plate, wherein the developer comprises a hydrophilic polymer comprising (m1) structural units derived from at least one compound comprising both a polyalkylene oxide chain and a free radical polymerizable group, and (m2) structural units derived from at least one compound copolymerizable with the free radical polymerizable group of (i) and comprising at least one functional group with pK | 2009-08-13 |
20090202949 | Producing method of wired circuit board - A producing method of a wired circuit board includes the steps of preparing a two-layer base material including a metal supporting layer and an insulating layer, covering an upper surface of the insulating layer and respective side end surfaces of the insulating layer and the metal supporting layer with a photoresist, placing a photomask so as to light-shield an end portion and a portion where a conductive layer is to be formed of the upper surface, exposing to light the photoresist covering the upper surface from above the photoresist via the photomask, exposing to light the photoresist covering the respective side end surfaces from below the photoresist, forming an exposed portion of the photoresist into a pattern by removing an unexposed portion thereof to form a plating resist, and forming an end-portion conductive layer and the conductive layer. | 2009-08-13 |
20090202950 | LASER IRRADIATION APPARATUS AND METHOD OF FABRICATING ORGANIC LIGHT EMITTING DISPLAY USING THE SAME - Provided are a laser irradiation apparatus and method of fabricating an organic light emitting display using the same. The laser irradiation apparatus includes a mask positioned below the laser generator, and the mask is patterned such that lengths of an upper portion and a lower portion of a mask pattern are patterned longer than a length of a middle portion of the mask pattern with respect to the scanning direction. The method of fabricating an organic light emitting display includes scanning a laser beam on a predetermined region of the donor substrate using the laser irradiation apparatus to form an organic layer pattern on the substrate. When the organic layer pattern is formed using a laser induced thermal imaging (LITI) method, the transfer may be carried out using a laser beam having low energy, laser beam efficiency may be enhanced, the organic layer may be less damaged, and the quality of the organic layer pattern to be transferred may also be enhanced. | 2009-08-13 |
20090202951 | CLEANING APPARATUS AND CLEANING METHOD, COATER/DEVELOPER AND COATING AND DEVELOPING METHOD, AND COMPUTER READABLE STORING MEDIUM - A cleaning apparatus includes a first substrate-holding portion configured to hold a first area of a back surface of the substrate so that the top surface is kept face up; a second substrate-holding portion configured to hold a second area of the back surface of the substrate, the second area being not overlapped with the first area, and rotate the substrate; a top-surface cleaning nozzle configured to supply a top surface cleaning fluid to a top surface of the substrate; a bevel cleaning nozzle configured to supply a bevel cleaning fluid to a bevel portion of the substrate; a cleaning fluid supplying portion configured to supply a back surface cleaning fluid to the back surface of the substrate held by the first or the second substrate-holding portion; and a cleaning member configured to clean the back surface of the substrate held by the first or the second-substrate holding portion. | 2009-08-13 |
20090202952 | SUBLITHOGRAPHIC PATTERNING METHOD INCORPORATING A SELF-ALIGNED SINGLE MASK PROCESS - A method of implementing sub-lithographic patterning of a semiconductor device includes forming a first set of patterned features with a single lithography step, the initial set of patterned features characterized by a linewidth and spacing therebetween; forming a first set of sidewall spacers on the first set of patterned features, and thereafter removing the first set of patterned features so as to define a second set of patterned features based on the geometry of the first set of sidewall spacers; and performing one or more additional iterations of forming subsequent sets of sidewall spacers on subsequent sets of patterned features, followed by removal of the subsequent sets of patterned features, wherein a given set of patterned features is based on the geometry of an associated set of sidewall spacers formed prior thereto, and wherein a final of the subsequent sets of patterned features is characterized by a sub-lithographic dimension. | 2009-08-13 |
20090202953 | Glycerin burning system - A glycerin burning system having a specialized atomizing burner capable of combusting a continuous feed of crude or pure glycerin. The burner includes a two-fluid mixing nozzle. The nozzle has an internal distributor which mixes two fluid feed streams as the fluids are expelled through an orifice. The distributor has channels which cause the air to swirl before mixing with the glycerin. An impingement pin is provided outside the orifice to diffuse the mixture and reduce combustion air speed. To improve performance, the burner's air feed line is subjected to combustion chamber to preheat the air passing through the feed line before the air is mixed with the glycerin. | 2009-08-13 |
20090202954 | Multifunctional fuel gas nozzle - The present invention discloses a multifunctional fuel gas nozzle such that the nozzle is generally applicable for both natural gas and liquefied gas with different pressures. The multifunctional fuel gas nozzle of the present invention comprises a hollow core, a shell which is tightly jointed to the rear end portion of the core, and a switch strip which is axially movable with respect to the shell. The above structure is always applicable by switching the switch strip whenever the shell is used for natural gas with a lower input pressure or liquefied gas with a higher input pressure. Therefore, natural gas and liquefied gas with different pressures can share the nozzle only by simple adjustment according to the present invention. | 2009-08-13 |
20090202955 | GASIFICATION FEED INJECTORS AND METHODS OF MODIFYING THE CAST SURFACES THEREOF - Gasification feed injectors for injecting fluids into a combustion chamber and methods of modifying the cast surfaces of such injectors are provided. In an embodiment, a feed injector for injecting a fluid into a combustion chamber comprises a nozzle defining an interior flow passage, the nozzle comprising a cast surface modified to have an ASTM grain size number of about 2 to about 9. | 2009-08-13 |
20090202956 | COMBUSTION CHAMBER OF A COMBUSTION SYSTEM - A combustion chamber of a combustion system has a combustion space, a support structure, a support element, and a heat shield. The heat shield has at least two segments, and each segment includes a liner element facing the combustion space and has an edge region, a gap communicating with the combustion space being formed between edge regions of adjacent segments, and a retaining device. The retaining device fixes the respective liner element on the support structure via the support element and forms a flange region that fits over the edge region of the respective liner element. The retaining device forms a first cooling passage with the support element and has at least one through-opening in the flange region. A cooling gas flows through the through.opening from the first cooling passage to the edge region. | 2009-08-13 |
20090202957 | Gas heating method, and gas-heating piping member - Provided are a heating method making it possible that when a gas inside the body of a piping member, such as a pipe, is heated, the heating efficiency is improved; and a gas-heating piping member making it possible to perform such a heating method easily. | 2009-08-13 |
20090202958 | Occlusion indicator & process - Processes for marking contacts of teeth, utilizing a soft polymer sheet. The sheet clearly marks contacts to facilitate disclosure and adjustment of interferences. An arch ( | 2009-08-13 |
20090202959 | Dental Implant Guide - In one embodiment of the present invention, a dental implant guide features a drill base operable to be secured inside of a human mouth. A drill guide is adjustably attached to the drill base. The drill guide is operable to guide the path of a drill bit down a drilling axis. | 2009-08-13 |
20090202960 | MEDICAL/DENTAL SUCTION NOZZLE HOLSTER HAVING A UNIVERSALLY ADJUSTABLE STRAP - A suction nozzle holster is provided with a latch mechanism for receiving a universally adjustable strap having a groove system whose individual grooves can engage with a pawl of a lever arm of said latch mechanism. A forward surface of the holster may be provided with a hole into which a suction hose can be forced in order to constrict said hose and, hence, curtail the vacuum conditions in a suction nozzle serviced by that hose. | 2009-08-13 |
20090202961 | Ultrasonic Dental Tool Having a Light Source - An ultrasonic dental insert having at least one light source. A first transducer generates ultrasonic vibrations. A connecting body has a proximal end and a distal end having a tip attached thereto. The proximal end is attached to the first transducer so as to receive the ultrasonic vibrations therefrom and to transmit the ultrasonic vibrations toward the tip attached to the distal end. A second transducer is disposed substantially proximate to the connecting body for generating a voltage signal in response to movement of a portion of the connecting body according to the ultrasonic vibrations. A magnetic material including a source of a magnetic field is present in close proximity to the insert. At least one light source substantially proximate or distal to the tip is connected to and receives the voltage signal from the second transducer to generate light. The ultrasonic dental insert may be inserted into a handpiece for providing electromagnetic energy to the first transducer to generate the ultrasonic vibrations. | 2009-08-13 |
20090202962 | Dynamic Pillar for Correcting Incorrectly Positioned Implants and a Toll Therefor - The invention relates to a dynamic pier which is used to modify and rectify angulations in the construction of structures on incorrectly-positioned implants. The invention comprises two independent parts forming of a link. According to the invention, the base has a semi-spherical configuration, while the end of the shaft that is coupled to the base has a complementary configuration. The above-mentioned link enables the shaft to form an angle of between 0 and 25° with the base. In addition, a screw is used to connect the base to the longitudinal auger of the implant which is introduced into the bone. Once cast, the aforementioned parts, base and shaft, form a single piece with the desired angulation, such that the prosthesis occupies the correct position regardless of the incorrect angular positioning of the implant in the bone. The inventive tool is equipped with a spherical actuation head. | 2009-08-13 |
20090202963 | Expandable polymer dental implant and method of use - Systems and methods for a dental implant system suitable for an endosteal implant into a jawbone are provided. The systems and methods make use of an expandable polymer sheath insertable into a jawbone, an implant insertable into the sheath and causing expansion of the sheath upon insertion, and an abutment adapted to be coupled to the implant and permitting the attachment of a dental prosthesis. | 2009-08-13 |
20090202964 | DRIVING SAFETY ASSESSMENT TOOL - A system and method for driving assessment includes multiple data sources, wherein results of tests from at least some of the multiple data sources are integrated. A driving assessment report including a driving recommendation is provided based on the integrated results. The multiple data sources may include cognitive tests, a background/medical data source, a visual/spatial skills data source, and a motor skills data source. A driving simulator may also be included. | 2009-08-13 |
20090202965 | Methods and Machine-Readable Media for Interactive Educational Tools - An application teaches a student elementary mathematics. A specific embodiment contains | 2009-08-13 |
20090202966 | Method For Assessing Auditory Attention And Vigilance - Provided are methods for assessing the attentional state of a subject by scoring the subject's response to auditory stimuli. The methods can be used to diagnose psychological and behavioral disorders, such as attention deficit disorder or hyperkinetic disorder. | 2009-08-13 |
20090202967 | COMPUTER-BASED EVALUATION TOOL FOR ORGANIZING AND DISPLAYING RESULTS OF DATASET ANALYSIS - A study that has a set of questions asked of a number of respondents and a set of corresponding answers. An evaluation tool evaluates every answer to a selected question to identify key terms therein, and develops a corresponding key term cloud based on the identified key terms of the selected question. The cloud is a visual representation of the identified key terms such that each key term appears in the cloud in a relative manner based on an attribute of the key term with regard to the answers. The tool displays the developed cloud for the selected question with the answers for the selected question, and a study evaluator views the relatively appearing key terms in the displayed cloud. Based thereon, the evaluator discerns trends in the answers to the selected question. | 2009-08-13 |
20090202968 | Systems and Methods for Combining Electronic Educational and Entertainment Media - In accordance with one aspect, electronic visual media is deemed by the user as interruptible or not interruptible. In accordance with another aspect, a timer determines when to interrupt interruptible media. In another aspect, media is interrupted by educational media comprising a question that is subsequently answered by a user. In another aspect, a correct response triggers dismissal of the interrupting question whereas an incorrect answer does not. In another aspect, correctly answering multiple questions in series accumulates time credit that delays further interruption of media. | 2009-08-13 |
20090202969 | CUSTOMIZED LEARNING AND ASSESSMENT OF STUDENT BASED ON PSYCHOMETRIC MODELS - A method, a device and a computer readable storage medium for conducting a customized educational session to assess or teach a student by selecting contents for presentation to the student based on descriptors associated with questions and/or incorrect responses. The contents presented include both questions for assessing the student's knowledge state and intervention materials for teaching the student. The descriptors associated with the questions and incorrect responses are analyzed using one or more psychometric models to estimate the deficiency or weakness of the student's learning. Next contents are selected or created based on the estimated deficiency or weakness in the student's learning. | 2009-08-13 |
20090202970 | Single-Click Support for Curriculum - At the click of a button, a student is connected with a live expert or teacher along with the resource the student is viewing. The student and the expert both have the same learning resource in a shared environment and the expert is able to help the student. After the live learning session, the student returns back to self-learning mode and continues with the original sequence. | 2009-08-13 |
20090202971 | On Track-Teaching - An interactive learning and behavioral modification system that utilizes computer hardware and software to create a learning scheme that is portable, individualized, and adjusts to each student. The system analyzes and manipulates the answers or data supplied by the students by a variety of means and then generates a new set of questions or tasks based on the individual student's performance. Problem difficulty is based on the student's performance and is increased or new material is introduced when a predetermined proficiency level has been attained. Furthermore, the data that is gathered from the students' replies is compiled and utilized as a tool to determine the effectiveness of the teacher allowing him or her to modify their teaching methods and improve on deficiencies. This allows the teacher to not only monitor the students' progress, but also their own. | 2009-08-13 |
20090202972 | Bi-Directional Communication of Simulation Information - Systems, methods, and associated software for providing a virtual reality experience for a user, particularly a virtual training experience, are described herein. A server associated with a virtual training system according to one embodiment, among others, comprises memory and a network interface. The memory is configured to store virtual training software and a simulation variations database. The virtual training software comprises training simulation logic adapted to provide a virtual training experience. The simulation variations database comprises data associated with preset variations to the virtual training experience. The network interface is configured to communicate with a remote client device within a network and is further configured to receive a first set of information from the client device associated with the virtual training software. Also, the network interface is further configured to transmit a second set of information to the client device associated with the virtual training software. | 2009-08-13 |
20090202973 | COMPUTER-BASED EVALUATION TOOL FOR ORGANIZING AND DISPLAYING RESULTS OF STUDY INTERVIEW - A study that has a set of questions asked of a number of respondents and a set of corresponding answers. An evaluation tool evaluates every answer to a selected question to identify key terms therein, and develops a corresponding key term cloud based on the identified key terms of the selected question. The cloud is a visual representation of the identified key terms such that each key term appears in the cloud in a relative manner based on an attribute of the key term with regard to the answers. The tool displays the developed cloud for the selected question with the answers for the selected question, and a study evaluator views the relatively appearing key terms in the displayed cloud. Based thereon, the evaluator discerns trends in the answers to the selected question. | 2009-08-13 |
20090202974 | EDUCATIONAL BATHROOM PLAY STATION - An educational bathroom play station for teaching bathroom hygiene to children includes a bathroom vanity ergonomically adapted for use by a child and having a base unit with a sink, a top unit above the base unit, and a plurality of designated spaces for toiletry items. A plurality of buttons displaying icons representative toiletry items and bathroom activities are disposed on the play station and connected to a plurality of item- and fixture-identifying light sources disposed adjacent the designated spaces, the buttons and light sources being part of a cueing circuit responsive to operation of at least one of the buttons to cause at least one of the light sources adjacent a toiletry item to emit light guiding a user to the toiletry item in response to operation of one of the plurality of buttons displaying an icon corresponding to the toiletry item. | 2009-08-13 |
20090202975 | VIRTUAL BLASTING SYSTEM FOR REMOVAL OF COATING AND/OR RUST FROM A VIRTUAL SURFACE - A computer simulation and virtual reality system simulates the use of a blasting nozzle to remove one or more coatings and/or rust from a virtual surface. The user operates an electronic controller in the form of a blasting nozzle that outputs a signal indicating whether the blasting nozzle controller is in an “on” position or in an “off” position. The system also has a motion tracking system that tracks the position and orientation of the blasting nozzle controller with respect to the virtual surface defined on the display screen. Simulation software in a computer generates virtual blast pattern data, and the removal of the virtual coating(s) and/or rust image from the virtual surface is displayed in real time on the display screen. | 2009-08-13 |
20090202976 | AMNIOPUNCH AND USES THEREOF - A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of collecting and storing a sample from a target tissue using a tissue harvesting device. A kit for collecting and storing samples of the target tissue. | 2009-08-13 |
20090202977 | DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES - The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ. | 2009-08-13 |
20090202978 | Method and apparatus for freezing of a biological material - The present invention provides a device for freezing biological material, comprising: a cooling unit; a heat insulation unit, having an interface with said cooling unit and a common longitudinal axis passing through said interface transversely thereto; an elongated slot disposed at least in said heat insulation unit and extending along said axis, said slot comprising a first slot portion remote from said interface and a second slot portion adjacent said interface; wherein said first and second slot portions have respective first and second dimensions measured perpendicularly to said slot's axis, the former being greater than the latter. | 2009-08-13 |
20090202979 | Production of antibody formats and immunological applications of said formats - The invention concerns an in-vitro method for introducing a targeted genome modification into an oocyte or an egg and a method for performing a random insertion in the genome of a host cell. | 2009-08-13 |
20090202980 | Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation - The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structures and the biological role of these cross-β structures. | 2009-08-13 |
20090202981 | Triple spin, double pool and revolumization process for concentrating platelets and derivative platelet concentrate - The present invention comprises an improved method of manufacturing platelet concentrate comprising the steps of: performing a first centrifugation of anticoagulated blood, pooling a first platelet rich sample, performing a second centrifugation on the first platelet rich sample whereby the volume of the first platelet rich sample placed in each subsequent centrifuge container is greater than the extracted volume from each previously utilized container, pooling a second platelet rich sample, performing a third centrifugation on the second platelet rich sample, whereby the volume of the second platelet rich sample placed in each subsequent centrifuge container is greater than the previous extracted volume from each previously utilized container, decanting a portion of supernatant overlying a third platelet rich sample, and suspending the third platelet rich sample such as to form a highly concentrated platelet rich formulation at concentrations greater than 8 times baseline and up to 60 times baseline. | 2009-08-13 |
20090202982 | BLOOD-VISCOSITY REDUCING AGENT - A blood-viscosity reducing agent contains a protein derived from | 2009-08-13 |
20090202983 | Method For Determining The Concentration of Virus Particles/Virus Antigens - The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination of the concentration of virus particles and/or virus antigens in a sample. | 2009-08-13 |
20090202984 | SINGLE MOLECULE NUCLEIC ACID SEQUENCE ANALYSIS PROCESSES AND COMPOSITIONS - Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that facilitates sequence analysis. The solid supports and methods provided herein minimize the number of steps required by published sequence analysis methodologies, and thereby offer improved sequence analysis efficiency. | 2009-08-13 |
20090202985 | METHOD AND APPARATUS FOR DETECTING AN ELECTRIC FIELD FLUCTUATION ASSOCIATED WITH THE PERMEABILIZATION OF A BACTERIAL CELL WALL - A sensor for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall comprises a substrate, at least two electrodes integrated on the substrate, an amplifier integrated on the substrate, and a processor electrically connected to the amplifier to analyze the amplified signal. The substrate and the at least two electrodes define a well between the at least two electrodes, and the at least two electrodes being configured to generate a signal in response to an electric field fluctuation in close proximity to the well or the electrodes triggered when at least one antibacterial agent associated with the well contacts a cognate target. The amplifier is configured to generate an amplified signal in response to the signal. In addition, the processor is electrically connected to the amplifier to analyze the amplified signal. | 2009-08-13 |
20090202986 | METHODS OF OPTIMIZING ANTIBODY VARIABLE REGION BINDING AFFINITY - The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the optimized heteromeric variable region binding fragments. | 2009-08-13 |
20090202987 | Canis sphingosine 1-phosphate receptor isoform 2 | 2009-08-13 |
20090202988 | Trap vectors and gene trapping using the same - A trap vector containing a loxP sequence composed of inverted repeat sequence | 2009-08-13 |
20090202989 | EGFR AND KRAS MUTATIONS - The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and KRAS and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated EGFR gene or mutated EGFR protein and/or mutated KRAS gene or protein in a tumor sample. | 2009-08-13 |
20090202990 | METHODS FOR THE SELECTION OF APTAMERS - The present invention generally relates to methods for selecting aptamers. More specifically, the invention provides methods for the selection of at least one aptamer for use in combination with another epitope binding agent such as another aptamer, an antibody, or a double stranded nucleic acid. The invention also encompasses methods for simultaneously selecting at least two aptamers that each recognize distinct epitopes on a target molecule. | 2009-08-13 |
20090202991 | NOVEL DIAGNOSTIC MARKERS, ESPECIALLY FOR IN VIVO IMAGING AND ASSAYS AND METHODS OF USE THEREOF - Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry. | 2009-08-13 |
20090202992 | POLYNUCLEOTIDE AND PROTEIN INVOLVED IN SYNAPTOGENESIS, VARIANTS THEREOF, AND THEIR THERAPEUTIC AND DIAGNOSTIC USES - The invention relates to a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins. | 2009-08-13 |
20090202993 | Use of DNA polymerases - Use of a DNA polymerase enzyme as a single stranded RNA exoribonuclease. | 2009-08-13 |
20090202994 | Human single nucleotide polymorphisms in ion channels and other proteins - The invention provides polynucleotide fragments corresponding to the genomic and/or coding regions of these genes which comprise at least one polymorphic site per fragment. Allele-specific primers and probes that hybridize to these regions, and/or that comprise at least one polymorphic site are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, paternity testing, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly cardiovascular diseases related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 2009-08-13 |
20090202995 | MOLECULAR CARDIOTOXICOLOGY MODELING - The present invention includes methods of predicting cardiotoxicity of test agents and methods of generating cardiotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents. | 2009-08-13 |
20090202996 | Genetic polymorphisms for identifying individuals at risk for drug-induced vestibular dysfunction - In this application is described the identification of genetic variants that contribute to susceptibility to drug-induced vestibular dysfunction, more particularly, GM-induced vestibular dysfunction. Methods, compositions and kits for determining whether an individual has susceptibility for drug-induced vestibular dysfunction are disclosed. | 2009-08-13 |
20090202997 | Cell-Free In Vitro Transcription and Translation of Membrane Proteins into Tethered Planar Lipid Layers - The present invention relates to synthetic membranes having membrane proteins incorporated therein and, in particular, to the cell-free in vitro transcription and translation of membrane proteins into tethered planar lipid layers. In particular, the present invention provides a new method for the preparation of such membranes. The membranes, e.g., can be used for investigation of membrane receptor/ligand interactions. | 2009-08-13 |
20090202998 | METHOD FOR THE EXTRACTION OF BIOMOLECULES FROM FIXED TISSUES - The present invention relates to a method for treating a fixed biological sample, comprising the steps of the method: i) provision of a fixed biological sample, ii) contacting the fixed biological sample with an aqueous solution comprising at least one nucleophilic reagent, and iii) heating the biological sample contacted with the aqueous solution. The invention also relates to the biological sample obtainable by this method, to the use of a nucleophilic reagent for the treatment of a fixed biological sample, to a kit for isolating a biomolecule from a fixed biological sample, to the use of this kit, and to a method for the treatment of a disease. | 2009-08-13 |
20090202999 | METHOD FOR DNA BREAKPOINT ANALYSIS - The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not only the identification of the breakpoint position but, further, enables the isolation of the DNA segment across which the breakpoint occurs. This provides a valuable opportunity to conduct further analysis of the breakpoint region, such as to sequence across this region. The method of the present invention is useful in a range of applications including, but not limited to, providing a routine means to characterise the gene breakpoint associated with disease onset in a patient and thereby enable the design of patient specific probes and primers for ongoing monitoring of the subject disease condition. In addition to monitoring the progression of a condition characterised by the existence of the breakpoint, there is also enabled assessment of the effectiveness of existing therapeutic drugs and/or new therapeutic drugs and, to the extent that the condition is a neoplasm, prediction of the likelihood of a subject's relapse from a remissive state. | 2009-08-13 |
20090203000 | DETECTION OF NUCLEIC ACIDS USING A CANTILEVER SENSOR - Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material. | 2009-08-13 |
20090203001 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers (e.g., polymorphisms and/or haplotypes) for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 2009-08-13 |
20090203002 | MESENCHYMAL STEM CELLS AS A VEHICLE FOR ION CHANNEL TRANSFER IN SYNCYTIAL STRUCTURES - The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective amplification of trophoblast/fetal specific sequences from DNA mixtures that contain a high proportion of non-trophoblast/fetal DNA. The invention also provides methods of using the amplified fetal DNA sequences for aneuploidy detection. | 2009-08-13 |
20090203003 | INHIBITION OF METALLO-BETA-LACTAMASE - A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of nucleic acids. The candidate mixture of nucleic acids is then allowed to make contact with the lactamase enzyme under controlled conditions of temperature, ionic strength and pH; the combination forms a candidate-enzyme mixture. The target nucleic acids are partitioned from the remainder of the candidate mixture. The target nucleic acids that have been partitioned are amplified to yield a pool of nucleic acids enriched with target nucleic acid sequences. The enriched pool of target nucleic acids have a relatively higher affinity and specificity for binding to the lactamase, whereby nucleic acid ligand of the lactamase are identified. Nucleic acid ligands that inhibit an activity of lactamase. The lactamase includes class B, metallo-β-lactamase. | 2009-08-13 |
20090203004 | NON-THIOPURINE METHYLTRANSFERASE RELATED EFFECTS IN 6-MERCAPTOPURINE THERAPY - The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a patient's risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient at a polymorphic site in at least one gene selected from the group consisting of a xanthine dehydrogenase (XDH) gene, molybdenum cofactor sulfurase (MOCOS) gene, and aldehyde oxidase (AOX) gene. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a 6-mercaptopurine drug by determining whether the patient should be given an alternative drug based on the presence or absence of a polymorphism in at least one of the XDH, MOCOS, and AOX genes. | 2009-08-13 |
20090203005 | NOVEL METHOD OF DESIGNING DNA PROBE CHIP FOR ROOM TEMPERATURE HYBRIDIZATION AND THE DNA PROBE CHIP - The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at a room temperature of 20° C.˜30° C. The method of designing DNA probe chip comprises designing DNA probe to start at −10˜+5 position that is between −10 position which is overlapped 10 sequences with primer and +5 position which is 5 sequences far from the 3′-terminal of primer, based on 0 position which is 3′-terminal of primer. | 2009-08-13 |
20090203006 | BIOLOGICAL MARKERS OF CHRONIC WOUND TISSUE AND METHODS OF USING FOR CRITERIA IN SURGICAL DEBRIDEMENT - The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds. | 2009-08-13 |
20090203007 | METHOD FOR OBTAINING AND INITIATING AMPLIFICATION OF A TARGET NUCLEIC ACID SEQUENCE - The present invention relates to oligonucleotides useful for determining the presence of | 2009-08-13 |
20090203008 | Rapid method to determine inhibitor sensitivity of NS3/4A protease sequences cloned from clinical samples - A method for measuring HCV NS3/4A activity from a HCV NS3/4A sequence, comprising obtaining and cloning the sequence into a mammalian expression vector, transiently transfecting a mammalian cell with the vector, which includes a reporter construct encoding a HCV NS3/4A cleavage site fused to a detectable label, measuring signal production from the label resulting from cleavage at the cleavage site, and measuring effects on signal production by addition of a test compound. | 2009-08-13 |
20090203009 | Novel method for high-throughput integrated chemical and biochemical reactions - The present invention relates to methods for monitoring in a high through-put fashion a multitude of molecular reaction processes, using a substrate, said substrate comprising a plurality of micro-channels, wherein each micro-channel has inlet and outlet open ends on opposing sides of said substrate, and wherein said micro-channels comprise at least one first reaction component, comprising the steps of: (a) contacting said micro-channels of said solid substrate with a sample, said contacting being via said inlet open ends, wherein said sample comprises an analyte, under conditions that allow said analyte to be specifically retained within said micro-channels by said first reaction component; (b) optionally removing excess of sample via said outlet open ends; (c) contacting the retained analyte with at least one second reaction component, said second reaction component being different from said first reaction component as defined in step (a), under conditions that allow a molecular reaction to take place, said reaction producing a signal; (d) detecting said signal and reading-out reaction results; (e) removing second reaction components via said outlet open ends; (f) repeating steps (c) to (e) at least once, wherein said at least one second reaction component as defined in (c) may be changed in composition; and, final detecting and reading-out of reaction results. The present invention also relates to the uses thereof as well as to microarrays and kits for performing said methods of the invention. | 2009-08-13 |
20090203010 | MSMB-gene based diagnosis, staging and prognosis of prostate cancer - This invention relates generally to a method of diagnosis for distinguishing between a benign prostate hyperplasia and a prostate cancer and between a hormone-sensitive and a hormone-refractory prostate cancer condition and specifically to identification of a hypermethylated (on CpG and non-CpG dinucleotides) CpG island in the beta-microseminoprotein (MSMB) regulatory regions surrounding the transcriptional start site of the MSMB gene as a diagnostic indicator of prostate cancer (PrCa) and for distinguishing androgen-refractory from androgen-sensitive prostate cancer. | 2009-08-13 |
20090203011 | METHODS AND NUCLEIC ACIDS FOR ANALYSES OF CELL PROLIFERATIVE DISORDERS - Particular aspects provide methods, nucleic acids and kits for detecting cell proliferative disorders. Preferred aspects provide genomic sequences, the methylation patterns of which have substantial utility for the improved detection of said disorders, providing for improved diagnosis and treatment of same in patients. | 2009-08-13 |
20090203012 | Metabolic Syndrome Genetics - A gene (and polymorphisms within it) was associated with multiple components of the metabolic syndrome. Methods of screening subjects to identify risk of metabolic syndrome and related conditions are described, as are methods of screening compounds to identify those that act on the gene product as a target for the treatment of these conditions. | 2009-08-13 |
20090203013 | Detection of Methicillin-Resistant Staphylococcus aureus - The present invention provides improved tests for the detection of methicillin-resistant | 2009-08-13 |
20090203014 | METHOD FOR DIAGNOSING AUTISM SPECTRUM DISORDER - The present invention provides methods of diagnosing and/or predicting autism spectrum disorder comprising determining the presence of microdeletions and microduplications on chromosomes 15 and 16. | 2009-08-13 |
20090203015 | MULTIPLEX ASSAYS FOR HORMONAL AND GROWTH FACTOR RECEPTORS, AND USES THEREOF - The present invention provides compositions and methods for simultaneously detecting mRNA expression levels of hormonal receptors, particularly both estrogen receptor (ER) and progesterone receptor (PR), optionally in combination with growth factor receptors, particularly epidermal growth factor receptor ERBB2 (Her-2), and further optionally in combination with control genes, such as the housekeeping genes NUP214 and/or PPIG. Exemplary embodiments of the invention are useful for determining hormonal receptor and/or growth factor receptor status, particular both ER and PR status and optionally also ERBB2 status, such as for assessing or treating breast cancer. | 2009-08-13 |
20090203016 | NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 85P1B3 USEFUL IN TREATMENT AND DETECTION OF CANCER - A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response. | 2009-08-13 |
20090203017 | Use of Nucleic Acid Probes to Detect Nucleotide Sequences of Interest in a Sample - The invention relates to methods for the determination and detection of nucleic acids sequences in a sample. The nucleic acid may be RNA or DNA or both. The invention also relates to methods for the determination of the presence and species of various microorganisms in a sample. We have also identified a set of oligonucleotide nucleic acid sequences within the rRNAs of Gram-negative organisms that facilitates both the broad identification of Gram-negative organisms as a class when used as a pool, or in combination, for example in a hybridization assay. This set of oligonucleotides may detect sequences that are indicative of the presence of organisms of the broad class of Gram-negative organisms while exhibiting little or no false identification of Gram-positive organisms, and fungi, or other microorganisms. The assay includes concurrent incubation with at least one nucleotide sequence of interest, at least one nucleic acid probe, a fluorosurfactant, and a nuclease. The assay may further be employed to detect the presence of bacteria, fungi, or other microorganisms by use of additional specific probes, or to detect and/or identify target nucleic acid sequences in a sample. Further, the invention also relates to methods of reducing non-specific binding and facilitating complex formation in a binding assay. The binding assay may be, but is not limited to, a nucleic acid hybridization assay or an immunoassay. The invention also relates to methods of detection that employ at least one target of interest, which may be a nucleotide sequence, at least one probe, which may be a nucleic acid probe and a nuclease. | 2009-08-13 |
20090203018 | NUCLEIC ACID DETECTION ASSAYS EMPLOYING BLOCKER OLIGONUCLEOTIDES - The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences. | 2009-08-13 |
20090203019 | Methods of Monitoring Metabolic Pathways - The present invention provides methods and compositions for monitoring cofactors and metabolites of a metabolic pathway of interest. The subject compositions and methods are particularly suited for monitoring the mevalonate pathway in a variety of cells. The invention also provides fermentation methods for the production of isoprenoids. | 2009-08-13 |
20090203020 | BOVINE POLYMORPHISMS AND METHODS OF PREDICTING BOVINE TRAITS - Methods of predicting the phenotype of a trait in a bovine subject are provided. The methods include obtaining information about polynucleotide sequences specifically regarding the identity of the nucleotides present at one or more identified single nucleotide polymorphisms and using this information to make predictions regarding the trait in the subject. Also provided are kits for and methods of determining the nucleotide present in a bovine subject at a position in which a single nucleotide polymorphism is correlated with a trait. | 2009-08-13 |
20090203021 | Detection of Clostridium difficile - The invention provides methods to detect | 2009-08-13 |
20090203022 | ANALYSIS - A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second part of the sample, the second analysis being conducted according to a procedure using a value for each of one or more characteristics of the procedure. The consideration of the results of the first analysis is used to determine whether the value for one or more of the characteristics of the procedure is changed to a different value. The second analysis is started before the results of the first analysis are obtained. | 2009-08-13 |
20090203023 | Concentrating Microorganisms in Aqueous Solution Prior to Selective Staining and Detection - Apparatus and methods for detecting a small number of target microorganisms found in a large volume of aqueous solution by diverting small volumes containing fluorescent microorganisms, including target microorganisms, into a smaller specimen of solution, followed by selectively staining the specimen to tag the target microorganisms and detecting the tagged target microorganisms. | 2009-08-13 |