22nd week of 2015 patent applcation highlights part 47 |
Patent application number | Title | Published |
20150148204 | Hands Free Exercise Device - A resistance exercise device is disclosed for an amputee which includes a support assembly configured to engage the stump portion of an amputated limb. The support assembly includes a pair of circumferential support cuffs. The support assembly includes inelastic adjustable bands with the support cuffs attached to the end thereof. The harness assembly is connected to a centrally located anchor, having a spacing member, that provides for a distribution of the user's weight between the arms. The device allows the user to selectively adjust the exercise load from nearly zero resistance to the user's full body weight. | 2015-05-28 |
20150148205 | FOAM EXERCISE BENCH - A foam exercise bench includes a single, elongated foam member, having a left side section, a right side section, a head end, a leg end, a flat bottom surface, and an angled top surface. The top surface forming a leg area, a seat area, an inclined back area and a generally flat area. These areas functioning to receive a user and to allow the same to perform a variety of strength training exercises. | 2015-05-28 |
20150148206 | ROLLER, AND METHOD FOR MANUFACTURING THE SAME - A roller is particularly suited for use in a machine for manufacturing and/or finishing a fibrous web, such as a paper web or cardboard web. The roller includes a roller core and, configured thereon, a roller covering. The covering has at least one layer of a resin material with at least one fiber material embedded therein. The at least one layer has an outer surface that is suitable for coming into direct or indirect contact with the fibrous web. The at least one fiber material here comprises fibers having a linear weight from 0.5 to 5 dtex, preferably from 0.5 to 2 dtex. | 2015-05-28 |
20150148207 | MEHOD AND DEVICE FOR FORMING CIGARETTE FILTER ROD - A method and device for forming a cigarette filter rod. The method is as follows: in a process of continuously conveying forward cigarette filter materials that tend to converge to have a rod shape, multiple granular additives are continuously output in accordance with a certain time interval, and are sprayed into the cigarette filter materials that converge forwards under the action of continuous transporting flows, so that after the cigarette filter materials converge to form a continuous filter rod, multiple groups of additive unit combinations formed of different granular additive units are embedded in an axial direction of the filter rod. With the method and device for forming a cigarette filter rod, a filter rod containing multiple granular additives can be formed in one step; multiple granular additives can be combined and arranged in any way along an axial direction of the filter rod; dosage positions and intervals of various granular additives can be adjusted and changed randomly; a production process is simplified and the production cost is reduced. | 2015-05-28 |
20150148208 | Method for Assembling Tubular Bodies Made from a Cardboard Material with a Sealing Structure - A method, a shaping tool and a machine for assembling a tubular cardboard body ( | 2015-05-28 |
20150148209 | COLLAPSIBLE CONTAINMENT BERM - Containment berms ( | 2015-05-28 |
20150148210 | ASSEMBLY FOR CUSTOM BOX BLANK PREPARATION AND METHOD - An assembly for preparing a box blank from a cardboard sheet. The assembly comprises a feeder for vertically feeding one of a plurality of the cardboard sheets from a storage position into a printing/cutting assembly, the printing/cutting assembly comprising a printing station comprising at least one printer head and a vertical conveyor for conveying a printing surface of the cardboard sheet proximate to and past the at least one printer head, wherein the printing surface is printed by the at least one printer head during the conveying, and a cutting station. Each of the printer heads and each of the cutting blades is vertically moveable respectively into a selected printing position and a selected cutting position under control of a controller thereby accommodating a plurality of different cardboard sheets of different sizes. | 2015-05-28 |
20150148211 | COMBINED FOLDING ROLLER MODULE - A combined folding roller module is disclosed. The combined folding roller module of the present invention comprises a shaft, a plurality of folding wheels and at least one bearing unit. In the present invention, an appropriate quantity of bearing units are used to support the combined folding roller at suitable locations for enhancing the strength of the combined folding roller module, reducing the deformation of the combined folding roller module, and reducing the vibration during operation. | 2015-05-28 |
20150148212 | PROCESS FOR REMOVING RED BLOOD CELLS AND CENTRIFUGAL TUBE FOR BLOOD COLLECTION - The present invention may provide a method of removing red blood cells and a centrifuge tube for blood collection, which method and centrifuge tube can, when cells contained in blood are observed after spreading the cells, improve detection accuracy of rare cells contained in the blood, hardly causing loss of the rare cells. The method of removing red blood cells may include the steps of: (A) fixing cells contained in a blood-derived sample; and (B) subjecting the blood-derived sample obtained in the Step (A) to density gradient centrifugation to separate the sample into at least two layers, one of which contains a large amount of red blood cells and the other of which contains a large amount of cells other than red blood cells. | 2015-05-28 |
20150148213 | LAMINAR-FLOW CENTRIFUGAL SEPARATOR - The rotary bowl ( | 2015-05-28 |
20150148214 | PROCESS FOR REGENERATING CATALYST IN A FLUID CATALYTIC CRACKING UNIT - One exemplary embodiment can be a process for regenerating catalyst in a fluid catalytic cracking unit. Generally, the process includes providing a feed to a riser of a reaction vessel, and providing a stream to a distributor positioned within a void proximate to an inlet receiving unregenerated catalyst in a regenerator. The feed can include at least one of a gas oil, a vacuum gas oil, an atmospheric gas oil, a coker gas oil, a hydrotreated gas oil, a hydrocracker unconverted oil, and an atmospheric residue | 2015-05-28 |
20150148215 | Methods for Selecting and Applying a Layer of Cu-Mn Spinel Phase to ZPGM Catalyst Systems for TWC Application - The present disclosure relates to selecting the layer of applying ZPGM active phase in washcoat, or applying ZPGM active phase in overcoat, for achieving optimized performance and enhanced thermal stability. Applying ZPGM active phase catalyst in overcoat shows improvements compare to applying ZPGM active phase in washcoat. The selected active phase material may include a chemical composition that is substantially free from PGM, including a formulation of stoichiometric Cu—Mn spinel structure active phase deposited on Niobium-Zirconium support oxide. The selected active phase layer applied in overcoat may include a washcoat of alumina coated on a suitable ceramic substrate. The disclosed active phase may be applied in overcoat to maximize efficiency of catalyst systems, which may exhibit enhanced catalytic activity properties, which may stable after aging and under steady state and oscillating condition, showing optimized performance purifying gases in TWC condition. | 2015-05-28 |
20150148216 | SPINEL COMPOSITIONS AND APPLICATIONS THEREOF - Spinels having a general formula of AB | 2015-05-28 |
20150148217 | METHOD FOR PRODUCING NOx REMOVAL CATALYST FOR HIGH-TEMPERATURE EXHAUST GAS - Provided is a method for producing a NOx removal catalyst for high-temperature exhaust gas, comprising: calcining a mixture comprising ZrO | 2015-05-28 |
20150148218 | STRONTIUM COBALTITE OXYGEN SPONGE CATALYST AND METHODS OF USE - Rapid, reversible redox activity may be accomplished at significantly reduced temperatures, as low as about 200° C., from epitaxially stabilized, oxygen vacancy ordered SrCoO | 2015-05-28 |
20150148219 | COMPOSITION INCLUDING A LANTHANUM PEROVSKITE ON AN ALUMINA OR ALUMINIUM OXYHYDROXIDE SUBSTRATE, PREPARATION METHOD AND USE IN CATALYSIS - The composition according to the invention includes a perovskite of the formula LaMO | 2015-05-28 |
20150148220 | Process for Elimination of Hexavalent Chromium Compounds on Metallic Substrates within Zero-PGM Catalyst Systems - Process for manufacturing ZPGM catalysts systems that may allow the prevention of formation or the conversion of corrosion causing compounds, such as hexavalent chromium compounds, within ZPGM catalyst systems is disclosed. In one embodiment, disclosed ZPGM catalysts systems, may include metallic substrate, which may include alloys of iron and chromium, a washcoat and an overcoat. Disclosed manufacturing process may include a thermal decomposition of hexavalent chromium compounds which may allow the decomposition of such compounds into trivalent chromium compounds, and may also produce metallic catalyst, such as silver. Such conversion may prevent corrosion formation, such as red color corrosion within ZPGM catalyst system. An embodiment of the disclosed process may include a reducing agent, which may be present in exhaust conditions, which may convert hexavalent chromium compounds into trivalent chromium compounds as well as produce metallic catalyst, such as silver. Employing the disclosed manufacturing process may allow the production of ZPGM catalyst systems that may exhibit high activity and enhanced performance. | 2015-05-28 |
20150148221 | CATALYST MATERIALS USEFUL FOR SOUR GAS SHIFT REACTIONS AND METHODS FOR USING THEM - The disclosure provides molybdenum and/or tungsten containing catalyst materials useful for the sour gas shift reactions and methods for using such catalyst materials, for example, for converting carbon monoxide and steam to carbon dioxide and hydrogen. | 2015-05-28 |
20150148222 | Effect of Support Oxides on Optimal Performance and Stability of ZPGM Catalyst Systems - The present disclosure relates to selecting support oxide for ZPGM catalyst for optimal performance under TWC condition, for achieving enhanced catalyst activity, and improved thermal stability during aging. The selected active phase material may include a chemical composition that is substantially free from PGM, including a formulation of stoichiometric Cu—Mn spinel structure active phase with Niobium-Zirconium support oxide, which may include a washcoat of pure alumina coated on a suitable ceramic substrate. The disclosed Cu—Mn spinel structure active phase with Niobium-Zirconium support oxide may be applied in overcoat to maximize efficiency of ZPGM catalyst systems, which may exhibit enhanced catalytic activity properties that may increase with temperature, showing optimized performance purifying gases in TWC condition, and enhanced stability during aging. | 2015-05-28 |
20150148223 | System and Methods for Using Synergized PGM as a Three-Way Catalyst - Synergies resulting from combinations of catalyst systems including Copper-Manganese material compositions and PGM catalysts are disclosed. Variations of catalyst system configurations are tested to determine most effective material composition, formulation, and configuration for an optimal synergized PGM (SPGM) catalyst system. The synergistic effect of the selected SPGM catalyst system is determined under steady state and oscillating test conditions, from which the optimal NO/CO cross over R-value indicates enhanced catalytic behavior of the selected SPGM catalyst system as compared with current PGM catalysts for TWC applications. According to principles in the present disclosure, application of Pd on alumina-based support as overcoat and Cu—Mn spinel structure supported on Nb | 2015-05-28 |
20150148224 | Oxygen Storage Capacity and Thermal Stability of Synergized PGM Catalyst Systems - Synergized PGM (SPGM) catalyst systems including ZPGM material compositions and formulations are disclosed. Variations of catalyst systems are tested to determine the synergistic effect of adding ZPGM material to PGM catalysts. The synergistic effect is determined under isothermal oscillating condition from which enhanced OSC property indicates enhanced catalytic behavior of disclosed SPGM catalyst systems as compared with commercial PGM catalysts with OSM for TWC applications. Disclosed SPGM catalyst systems is free of rare earth metals and especially Ce and may have an optimal OSC property and optimal thermal stability that increases with the temperature, showing acceptable level of O | 2015-05-28 |
20150148225 | Systems and Methods for Managing a Synergistic Relationship Between PGM and Copper-Manganese in a Three Way Catalyst Systems - Synergized Platinum Group Metals (SPGM) catalyst systems for TWC application are disclosed. Disclosed SPGM catalyst systems may include a washcoat with a Cu—Mn spinel structure, Cu | 2015-05-28 |
20150148226 | COLUMN PACKING MATERIAL, COLUMN USING THE SAME, AND METHOD OF SEPARATION USING THE SAME - Aimed at readily and exactly separate 8-hydroxy-2′-deoxyguanosine (8-OHdG) contained in a sample, a column packing material used for separating 8-OHdG, which contains a packing material composed of a material having a straight-chain hydrocarbon group having 6 or more and 30 or less carbon atoms as a functional group, and having a carbon content over the surface of carrier of 18% or less by element ratio, wherein the packing material contains 1 cumulative percent or more and 20 cumulative percent or less, on the particle-count basis, of particles having a circle-equivalent diameter, measured using a flow-type particle image analyzer, of 0.5 μm or larger and 10 μm or smaller, is used. | 2015-05-28 |
20150148227 | MARKING SYSTEM - A marking system comprises a substrate having a surface coated with a color-triggering developer and a deactivating ink composition; and a marking composition comprising at least one color precursor. At least one “non-color developing portion” of the surface is coated with both the color-triggering developer and the deactivating ink composition, and at least one “color-developing portion” of the surface is coated with the color-triggering developer and is not coated with the deactivating ink composition. Color development occurs at the color-developing portion(s) and does not occur at the non-color developing portion(s) upon application of the marking composition to the surface of the substrate. | 2015-05-28 |
20150148228 | COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND A FUNGICIDE - The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts. | 2015-05-28 |
20150148229 | COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND A FUNGICIDE SELECTED FROM INHIBITORS OF AMINO ACID OR PROTEIN BIOSYNTHESIS, INHIBITORS OF ATP PRODUCTION AND INHIBITORS OF THE CELL WALL SYNTHESIS - The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts. | 2015-05-28 |
20150148230 | COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE - The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts. | 2015-05-28 |
20150148231 | MIXTURES FOR REDUCING NITROUS OXIDE AND/OR AMMONIA EMISSION FROM SOILS - The present invention relates to an agrochemical mixture for reducing nitrous oxide and/or ammonia emission from soils, comprising: | 2015-05-28 |
20150148232 | CONTROL OF PLANT DISEASES AND ENHANCING PLANT GROWTH USING A COMBINATION OF A TRICHODERMA VIRENS SPECIES AND A RHIZOSPHERE COMPETENT TRICHODERMA HARZIANUM SPECIES - The combination of a | 2015-05-28 |
20150148233 | HERBICIDAL AGENTS CONTAINING FLUFENACET - Herbicidal compositions having an effective amount of flufenacet and the further herbicides aclonifen and diflufenican. | 2015-05-28 |
20150148234 | HERBICIDE-RESISTANT SUNFLOWER PLANTS WITH MULTIPLE HERBICIDE RESISTANT ALLELES OF AHASL1 AND METHODS OF USE - Herbicide resistant sunflower plants comprising two different herbicide-resistant alleles of the sunflower acetohydroxyacid synthase large subunit 1 (AHASL1) gene are described. Methods for making these sunflower plants and methods for controlling weeds or other undesired vegetation growing in the vicinity of these sunflower plants are disclosed. Such methods involve the use of acetohydroxyacid synthase-inhibiting herbicides. Methods for controlling parasitic weeds growing on sunflower plants are also described. Additionally provided are methods for determining the genotype of sunflower plants for AHASL1 gene. | 2015-05-28 |
20150148235 | HERBICIDE-RESISTANT SUNFLOWER PLANTS WITH MULTIPLE HERBICIDE RESISTANT ALLELES OF AHASL1 AND METHODS OF USE - Herbicide resistant sunflower plants comprising two different herbicide-resistant alleles of the sunflower acetohydroxyacid synthase large subunit 1 (AHASL1) gene are described. Methods for making these sunflower plants and methods for controlling weeds or other undesired vegetation growing in the vicinity of these sunflower plants are disclosed. Such methods involve the use of acetohydroxyacid synthase-inhibiting herbicides. Methods for controlling parasitic weeds growing on sunflower plants are also described. Additionally provided are methods for determining the genotype of sunflower plants for AHASL1 gene. | 2015-05-28 |
20150148236 | LASER PROCESSING OF SUPERCONDUCTOR LAYERS - A method of forming a superconductor includes exposing a layer disposed on a substrate to an oxygen ambient, and selectively annealing a portion of the layer to form a superconducting region within the layer. | 2015-05-28 |
20150148237 | Method for Generating Aptamers with Improved Off-Rates - The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods. Specifically, the present disclosure describes methods for the identification and use of aptamers to one or more targets within a histological or cytological sample, which have slow rates of dissociation. The aptamers may be used to assess localization, relative density, and presence or absence of one or more targets in cytological and histological samples. Targets may be selected that are specific and diagnostic of a given disease state for which the sample was collected. The aptamers may also be used to introduce target specific signal moieties. In addition to target identification, the aptamers may be used to amplify signal generation through a variety of methods. | 2015-05-28 |
20150148238 | DROPLET-BASED SURFACE MODIFICATION AND WASHING - The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet microactuator including a droplet including one or more beads and immobilizing at least one of the one or more beads. The method further includes conducting one or more droplet operations to divide the droplet to yield a set of droplets including a droplet including the one or more immobilized beads and a droplet substantially lacking the one or more immobilized beads. | 2015-05-28 |
20150148239 | SPATIAL MOLECULAR BARCODING OF IN SITU NUCLEIC ACIDS - This disclosure provides, among other things, a method for analyzing a planar cellular sample. In some embodiments, the method comprises: (a) indirectly or directly attaching nucleic acid tags to binding sites in a planar cellular sample; (b) contacting the planar cellular sample with a solid support comprising an array of spatially addressed features that comprise oligonucleotides, wherein each oligonucleotide comprises a molecular barcode that identifies the feature in which the oligonucleotides is present; (c) hybridizing the nucleic acid tags, or a copy of the same, with the oligonucleotides to produce duplexes; and (d) extending the oligonucleotides in the duplexes to produce extension products that each comprises (i) a molecular barcode and (ii) a copy of a nucleic acid tag. Other embodiments, e.g., kits and the like, are also described. | 2015-05-28 |
20150148240 | UNIVERSAL METHYLATION PROFILING METHODS - This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. | 2015-05-28 |
20150148241 | METHOD FOR GENOME SEQUENCING - The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular markers. | 2015-05-28 |
20150148242 | SCREENING METHOD AND SYSTEMS UTILIZING MASS SPECTRAL FRAGMENTATION PATTERNS - The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures. Therefore the methods and systems of the present application represent an approach that is uniquely capable of navigating chemical space and providing a understanding of desired families and pharmacophores. | 2015-05-28 |
20150148243 | METHOD FOR REVERSIBLE FIXATION OR SELECTIVE LYSIS OF CELL USING PHOTOCLEAVABLE POLYMER - A photocleavable polymer comprising a photocleavable linker and a polymer having a functional group that binds to a protein, lipid, sugar of a cell, or any combination thereof, as well as a method of selectively lysing cells by incubating a sample comprising two or more cells with the photocleavable polymer to reversibly fix the cells; selectively irradiating the fixed cells or a target or non-target cell among the fixed cells to cleave the photocleavable polymer; and adding a cell lysis solution to selectively lyse the irradiated cells. | 2015-05-28 |
20150148244 | METHODS FOR DETERMINING RESPONSIVENESS TO A DIHYDROFOLATE REDUCTASE INHIBITOR - The present disclosure provides methods for predicting or determining the sensitivity of a cell and/or biological sample obtained from a subject to a DHFR inhibitor including, for example, an antifolate such as Methotrexate or Pemetrexed. Such methods may comprise determining the expression level of one or more miRNAs (e.g., one or more members of the miR-181 and/or miR-143 families) in a cell or biological sample. The methods may be used to determine the responsiveness of a subject to treatment with a DHFR inhibitor. | 2015-05-28 |
20150148245 | Methods of Monitoring Responsiveness to Anti-SMAD7 Therapy - Methods for monitoring whether a subject will be sensitive or resistant to treatment with an anti-SMAD7 therapy are disclosed. The methods are based on the determining of the amount of CCR9+ FOXP3+ T cells, CCR9+ IFN-gamma+ T cells, CCR9+ IL17A+ T cells, FOXP3+ T cells, IFN-gamma+ T cells, and/or IL17A+ T cells in a sample from the subject. Measurement of T cell populations may be determined by flow cytometry, immunohistochemistry, and/or ELISA. | 2015-05-28 |
20150148246 | SURFACE ANCHORED LIGHT CHAIN BAIT ANTIBODY DISPLAY SYSTEM - The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest. | 2015-05-28 |
20150148247 | METHODS AND DEVICES FOR TUBERCULOSIS DIAGNOSIS USING BIOMARKER PROFILES - The invention relates to tuberculosis diagnostic methods and devices that measure particular biomarker profiles in subjects and identify a subject having tuberculosis based on such profiles. | 2015-05-28 |
20150148248 | MMP2 AS A PREDICTIVE BIOMARKER OF RESPONSE TO ANTIANGIOGENIC THERAPY AND SURVIVAL AFTER THERAPY IN CANCER PATIENTS - The present invention relates to the use of matrix metalloproteinase-2 (MMP2) as a predictive biomarker of response to antiangiogenic therapy and survival after antiangiogenic therapy in cancer patients, and to related methods for predicting or monitoring the response to an antiangiogenic treatment and the survival after said treatment of a cancer patient. | 2015-05-28 |
20150148249 | METHOD OF IMPROVING THE SENSITIVITY OF COMPETITIVE IMMUNOASSAY - The present invention discloses a method improving the sensitivity of competitive immunoassay, mainly, the small molecular substances for detection first react with the antibody/receptor sufficiently, then react with the second molecules, which locates on the solid phase and participates the competitive reactions, in a short time, which may greatly improve the sensitivity of competitive immunoassay. The present invention owns an easy operation method and a low cost, does not require expensive equipments or professional technological personnel, also, it owns a high sensitivity and adapts to a plurality of immunoassay methods. | 2015-05-28 |
20150148250 | AMPLIFICATION REPORTER WITH BASE-PAIRING OLIGOMERS - System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected. | 2015-05-28 |
20150148251 | AUTISM ASSOCIATED GENETIC MARKERS - The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (ASD). The present disclosure includes methods related to the association of certain genetic markers with autism and/or ASD. More particularly, the present disclosure is related to methods and diagnostic tests for diagnosing or predicting ASD in an individual. | 2015-05-28 |
20150148252 | MULTIPLEX TARGET DETECTION ASSAY - Provided herein are reagents and kits for detection of multiple target sequences in a single-tube, single-color assay, and methods of use thereof. In particular, multiplex assays are provided for the detection of | 2015-05-28 |
20150148253 | CELL WITH SURFACE COATED WITH ANXA1 AND USE THEREOF - A cell having a surface coated with Annexin A1 (ANXA1), a method of detecting a substance binding to ANXA1 using the cell, and a method of preparing the cell are provided. | 2015-05-28 |
20150148254 | Diffuse Large B-Cell Lymphoma Markers and Uses Therefor - The present invention provides methods and compositions for prognosing treatment outcome in DLBCL patients, diagnosing DLBCL and monitoring efficacy of DLBCL treatment. | 2015-05-28 |
20150148255 | APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL - This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps. | 2015-05-28 |
20150148256 | BIOLUMINESCENCE IMAGING-BASED SCREENING ASSAY AND INHIBITORS OF ABCG2 - A bioluminescence imaging-based high-throughput assay for inhibitors of ABCG2 is described. Compositions of inhibitors of ABCG2 and methods of using ABCG2 inhibitors are also described. | 2015-05-28 |
20150148257 | DETECTING ANALYTES - Provided is a method for detecting analyte in a sample, which method comprises:
| 2015-05-28 |
20150148258 | METHOD FOR SIMULTANEOUS DETECTION, RECOVERY, IDENTIFICATION AND COUNTING OF MICROORGANISMS AND DEVICES FOR THE IMPLEMENTATION OF SAID METHOD - The present invention describes a method and devices for the simultaneous detection, recovery identification and counting of a plurality of microorganisms consisting in providing mixtures of nutrients specially selected from those that curtail the lag phase of growth in bacteria and moulds and which, together with fluorescent enzymatic, chromogenic or bioluminescent markers and other nutrient components or growth inhibitors, are embedded in three-dimensional structures or natural or artificial clays or ceramics with cavities of different dimensions and forms and specific surface areas of between 2×103 and 6×108 m | 2015-05-28 |
20150148259 | NOVEL PHENYL GLYOXAL PROBES - Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described. | 2015-05-28 |
20150148260 | ANALYTE MASS SPECTROMETRY QUANTITATION USING A UNIVERSAL REPORTER - Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter. | 2015-05-28 |
20150148261 | SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES - Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity. | 2015-05-28 |
20150148262 | MICROPARTICLE ASSEMBLY - A bead construct includes a bead, a fluorophore molecule, first and second linker molecules and a ligand molecule. The fluorophore molecule comprises at least two subunits connected to each other by at least one internal linker that provides conformational freedom to the at least two subunits. An optical signal emitted by the fluorophore molecule changes when reducing the conformational freedom of the at least two subunits to each other. The first linker molecule is connected to the bead and to one of the subunits of the flurophore molecule. The second linker molecule is connected to another one of the subunits of the fluorophore molecule. The ligand molecule is connected to the second linker molecule. | 2015-05-28 |
20150148263 | METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES - The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid support under conditions to attach each species at a desired density, thereby producing a derivatized support having attached capture molecules. The derivatized support is treated with a second mixture of different molecular species, wherein different molecular species in the second mixture bind specifically to the different capture molecules attached to the solid support. One or more of the capture molecules can be reversibly modified such that the capture molecules have a different activity before and after the second mixture of molecular species are attached. In particular embodiments, the different molecular species are nucleic acids that are reversibly modified to have different activity in an amplification reaction. | 2015-05-28 |
20150148264 | SYSTEMS AND METHODS FOR AUTOMATED REUSABLE PARALLEL BIOLOGICAL REACTIONS - A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat. The beads may be trapped in the form of an array of localized magnetic field regions. | 2015-05-28 |
20150148265 | SYSTEMS AND DEVICES FOR PROFILING MICROBIOTA OF SKIN - Devices and systems for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including a substrate and a location information storage component, the substrate including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual. | 2015-05-28 |
20150148266 | ANTI-AGGLOMERANTS FOR CONTROLLING GAS HYDRATES - The present invention generally relates to one or more compositions and methods for inhibiting the formation of gas hydrate agglomerates in a fluid. The fluid may be contained, for example, in an oil or gas pipeline or refinery. | 2015-05-28 |
20150148267 | GLYCOSYL HYDROLASE ENZYMES IN HIGH TEMPERATURE INDUSTRIAL PROCESSES - Novel hyperthermophilic | 2015-05-28 |
20150148268 | FOAMERS FOR DOWNHOLE INJECTION - This invention relates generally to novel foamer compositions for treatment of oil and gas wells to enhance production. The invention provides a method of foaming a fluid. The method includes introducing into the fluid a foam-forming amount of a composition comprising at least one long chain fatty acid and at least one organic solvent. An example of the long chain fatty acid is tall oil fatty acid and an example of the organic solvent is ethyleneglycol monobutyl ether. | 2015-05-28 |
20150148269 | SMART POLYMER FLOODING PROCESS - Design and preparation of a smart system, including a hydrophilic polymer nanoparticle as a core material and a hydrophilic-hydrophobic block copolymer as a coating nanolayer for use in a smart core-shell nanostructure flooding during enhanced oil recovery (EOR) process. The hydrophilic polymers are prepared by an inverse emulsion method. The central core of this nanostructure includes hydrophilic polymer. The nanolayer can be a surfmer. The binary properties of the shell and hydrophilic polymers increase the water viscosity in the water-oil interface and enhance oil recovery. | 2015-05-28 |
20150148270 | ACID EMULSION FOR ACID TREATMENT OF OIL RESERVOIRS - The acid emulsion for acid treatment of oil reservoirs is an emulsion for the acid treatment of the rock reservoir around oil well bores. The acid emulsion includes an oil, such as kerosene, and an emulsifier added to the volume of oil to form an oil-emulsifier mixture. The emulsifier forms about 0.1 wt % of the oil-emulsifier mixture, and is preferably an organically modified montmorillonite clay. Brine is added to the oil-emulsifier mixture to form the acid emulsion. Preferably, the brine has a salt concentration of about 20 kppm, and is added such that the volume ratio of the brine to the oil is about 70 to 30. | 2015-05-28 |
20150148271 | SLIDING LAYER AND SLIDING ELEMENT PROVIDED WITH SAID TYPE OF SLIDING LAYER - The invention relates to a sliding layer based on a fiber-reinforced plastic, having a plastic matrix and at least one plastic thread as a reinforcement element. Said plastic matrix comprises at least one metal soap, preferably based on lithium stearate. No stick-slip effect occurs when using said sliding elements comprising said type of sliding layers, with steel counter elements. | 2015-05-28 |
20150148272 | GEAR AND ENGINE OILS WITH REDUCED SURFACE TENSION - A gear or engine oil or other type of lubricant, which effectively reduces churning losses in a dip lubrication system or any lubrication system where churning loss occur has a surface tension less than 28 mN/m and viscosity less than 400 mPa-sec at 25° C. (about 500 cSt at 25° C.). Formulations include Group I-IV base oil, in combination with an amount of silicone oil effective to decrease the surface tension of the oil, thereby reducing churning losses. When the base oil is prominently Group III, the coefficient of friction of the gear oil is also reduced. | 2015-05-28 |
20150148273 | THERMALLY-CURABLE HEAT-CONDUCTIVE SILICONE GREASE COMPOSITION - Provided is a thermally-curable heat-conductive silicone grease composition which has a high shape-retaining property in an early stage even when the viscosity of the composition is low (i.e., the composition is easy to apply) in the early stage, and which becomes soft (has low hardness) after being cured. A thermally-curable heat-conductive silicone grease composition comprising, as essential components:
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20150148274 | CONTINUOUS LITHIUM COMPLEX GREASE MANUFACTURING PROCESS WITH A BORATED ADDITIVE - A continuous process with increased production throughput of a high dropping point lithium complex grease composition comprising the steps of heating a mixture of a C | 2015-05-28 |
20150148275 | STAR POLYMER AND LUBRICATING COMPOSITION THEREOF - The present invention relates to a lubricating composition containing an oil of lubricating viscosity and a star polymer that has at least two inner blocks, at least one of which is in turn bonded to one or more outer blocks. The invention further relates to methods of lubricating a mechanical device with the lubricating composition. | 2015-05-28 |
20150148276 | SANITIZER SHEETS FOR REMOVING PARTICLES FROM SKIN - A waterless hand cleaner that pulls dirt and debris particles out of the crevices and pores of skin, thus removing harmful contaminants and bacteria along with it. The hand cleaner is a flexible sticky hand cleaner sheet with a sticky adhesive that secures and removes dirt and exfoliates loose and/or dead skin from the palms and fingers of the user's hand. The hand cleaner sheets can be dispensed from a roll, or dispensed as individual sheets. | 2015-05-28 |
20150148277 | COMBINATION PRODUCT HAVING A HIGH VISCOSITY - The invention relates to fluid washing or cleaning products which are present as combination products comprising a packaging means and at least two fluid washing or cleaning compositions A and B that are located in said packaging means and that are separate from each other, wherein the two compositions A and B comprise A: 10 to 75 wt % of builder material(s); 0.1 to 10 wt % of enzyme preparation; 24.9 to 89.9 wt % of water; and B: less than 0.1 wt % of enzyme preparation; 0.5 to 90 wt % of water and at least one further ingredient of washing or cleaning products, and which fluid washing or cleaning products have an improved stability if the viscosity of the compositions A and B is above 1500 mPas. | 2015-05-28 |
20150148278 | NOVEL CLEANING METHOD - The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the formulation is free of organic solvents. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one cleaning material and, in this embodiment, it is preferred that the polymeric particles are coated with the at least one cleaning material. Preferably, the cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fibre. Typically, the polymeric particles comprise particles of nylon, most preferably in the form of nylon chips. The results obtained are very much in line with those observed when carrying out conventional dry cleaning processes and the method provides the significant advantage that the use of solvents, with all the attendant drawbacks in terms of cost and environmental considerations, can be avoided. | 2015-05-28 |
20150148279 | METHOD OF REMOVING POLYMERIC CONTAMINANTS FROM PAPERMAKING SURFACES - Embodiments of methods of removing polymeric soils from papermaking machine surfaces including developing a solvent blend that is a solubility match for the polymeric soils as defined by a Hansen Solubility factor less than 4 for all polymeric soils, producing an aqueous cleanser comprising the solvent blend, and applying the aqueous cleanser to papermaking surfaces such that the aqueous cleanser solubilizes and removes the polymeric soils from papermaking surfaces. The solvent blend comprises at least one aromatic alcohol, at least one dibasic ester, and at least one terpene solvent. | 2015-05-28 |
20150148280 | Activation of Peroxygen Bleach - A peracid bleaching species is formed in situ in aqueous wash liquor by reaction of a peroxygen bleach precursor, such as perborate or percarbonate, and a bleach activator. The bleach activator is an acetylated ethylene diamine, that comprises at east 25% triacetyl ethylene diamine. The peracid is formed more rapidly even at low temperatures (F2) compared to use of conventional pure tetracetyl ethylene diamine (F1) and better disinfectant properties result. | 2015-05-28 |
20150148281 | ADHESIVE DETERGENT AND/OR PERFUMING COMPOSITION - An adhesive detergent and/or perfuming composition, in the form of gel or a paste, directly applicable onto the surface of interest, adhering thereto without the aid of a support and/or container, and from which, if subjected to the action of water, is removed only after a great number of flushing operations, comprising
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20150148282 | Multiphase Surfactant Fragrance Composition - A multicomponent composition separating surfactant and fragrance into separate phases to increase the fragrance release from the composition. | 2015-05-28 |
20150148283 | NOVEL CASEIN PROTEIN PRODUCT - The present invention relates to a process for producing a casein protein product comprising the steps of:—providing a casein concentrate starting material,—heat-treating the material,—cooling the heat-treated material,—subjecting the cooled material to a treatment with a crosslinking enzyme,—optionally subjecting the cooled material to a treatment with a coagulant and—processing the material into the casein protein product/allowing the casein protein product to form. | 2015-05-28 |
20150148285 | SALT AND PROTEASE-RESISTANCE OF ANTIMICROBIAL PEPTIDE AND THE MANUFACTURE THEREOF - The present invention provides an antimicrobial peptide, wherein the amino terminal and/or carboxyl terminal of the peptide is linked with at least one artificial bulkyl amino acid to increase the salt resistance and protease resistance of the antimicrobial peptide. The antimicrobial peptide of the invention has a high salt resistance, a high protease resistance, and a low hemolytic activity, simultaneously. | 2015-05-28 |
20150148286 | POTENTIATION OF ANTIBIOTIC TREATMENT WITH A PROTEIN-LIPID COMPLEX - Provided are compositions and methods for potentiating the effect of antibiotics. The compositions comprise a non-covalent complex of alpha-lactalbumin and fatty acid. The fatty acids are cis, unsaturated, C14 to C20 fatty acids. The complex and antibiotic can be administered to an individual together or separately. The antibiotic may be one to which resistance has developed. | 2015-05-28 |
20150148287 | CATHETER LOCK SOLUTION FORMULATIONS - A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial. | 2015-05-28 |
20150148288 | Toxic Peptide Production, Peptide Expression in Plants and Combinations of Cysteine Rich Peptides - New insecticidal proteins, nucleotides, peptides, their expression in plants, methods of producing the peptides, new processes, production techniques, new peptides, new formulations, and new organisms, a process which increases the insecticidal peptide production yield from yeast expression systems. The present invention is also related and discloses selected endotoxins we call cysteine rich insecticidal peptides (CRIPS) which are peptides derived from | 2015-05-28 |
20150148289 | PEGYLATED OXM VARIANTS - A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed. | 2015-05-28 |
20150148290 | Macrocyclic Modulators of the Ghrelin Receptor - The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders. | 2015-05-28 |
20150148291 | LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME - A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed. | 2015-05-28 |
20150148292 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO - The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain embodiments, the disclosure relates to compositions comprising one or more compound(s) disclosed herein, such as 2-(2-Methoxybenzylidene)-1-indan-one; N-(4-arsonophenyl)glycine; 1,2-Benzenedicarboxylic acid, 1-(1-methylheptyl)ester; (4′-hydroxybiphenyl-4-yl) (phenyl)methanone; 2,2-dimethylchroman-6-carboxylic acid, (4,7-dihydroxy-8-methyl-2-oxo-2H-chromen-3-yl)amide; Ethyl 2-((4-chlorophenyl)thio)-1,3-benzothiazol-6-yl carbamate; Ethyl (2-(azepan-1-yl)benzo[d]thiazol-6-yl) carbamate; Porfiromycin; 1,3-benzodioxol-5-yl-[4-(3,4,5-trimethoxybenzoyl)-3-furyl]methanone; Tricinolone acetophenonide; 2,4-bis(3,4-dimethoxyphenyl)-4H-pyrano[3,2-c]chromen-5-one; Methyl 5-fluoro-4-methoxy-2,6-dioxohexahydro-5-pyrimidine carboxylate; 5-(naphthalen-1-yl)-1-phenyl-1h-tetrazole; 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazol-2-ol; N-[2,4,5-trimethyl-4-(trichloromethyl)cyclohexa-2,5-dien-1-ylidene]hydroxylamine; 4-benzoyl-3,4-dihydro-Benzo[f]quinoline-3-carbonitrile; 2-nitro-3-phenylspiro[cyclopropane-1,9′-fluorene]; 3-[4-(furan-2-ylmethyl)-5-sulfanylidene-1,2,4-dithiazolidin-3-ylidene]-1,1-dimethyl-thiourea; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; 5-Iodo-1H-indole-2,3-dione; 4,5-dihydro-1,2,9,10-tetramethoxy dibenzo[de,g]quinoline-6-carboxylic acid, ethyl ester; [2,6-bis(2,4-dimethylphenyl)-4-(2-methoxyacetyl)oxy-phenyl]2-methoxyacetate; 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6H-pyrido[4,3-b]carbazol-2-ium-9-ol; 2-[3-[[4-[(3-nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidine; 1-[[2-(dimethylamino)ethyl]amino]-7-hydroxy-4-methyl-9H-thioxanthen-9-one; 5-amino-1H-1,2,4-triazole-3-carboxylic acid, methyl ester; methyl N-cyano-N′-prop-2-en-1-ylcarbamimidothioate; 5,7-dinitro-8-quinolinol; 5-nitrosoquinolin-8-ol; Cantharidin; 1,7-Diaminoacridine; 3-Methyl-3-(1-naphthyl)-2-benzofuran-1(3H)-one; Dichlorolapachol; Lycobetaine; 6-(1-aziridinyl)-2,3-dihydro-3-(propionyl)-7-methyl-1H-Pyrrolo[1,8]-dione; 4-Nitroestrone 3-methyl ether; 5,11-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide hydrochloride; 5-Methoxysterigmatocysin; (6-acetamido-7-methyl-5,8-dioxo-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-3-yl)2-methoxyacetate; Horminon; 7′,8′-dimethyl-2′-oxo-4′,4a′,6a′,7′-tetrahydro-2′H-spiro[oxirane-2,1′-pentaleno[1,6a-c]pyran]-5′-carboxylate; Nybomycin acetate; 5H-[1,6]indeno[1,2-c]isoquinoline-5,12-dione; 2,3-dimethoxy-6-methyl-Nitidine; Iproplatin; 3-[(deoxyhexosyl)oxy]-2-(3,4-di-hydroxyphenyl)-6,8-dihdroxy-4H-1-Benzopyran-4-one; 2-O-benzyl 8-O-methyl 3-(4-methylphenyl)sulfonyl-4,5-dioxo-6H-pyrrolo[3,2-e]indole-2,8-dicarboxylate; 6-bromo-5,8-dihydroxy-7-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione; 5-methylbenzo[c]phenanthridin-5-ium-2,3,8,9-tetrol; (6-acetyl-4-oxo-1,3-diphenyl-2-sulfanylidenethieno[2,3-d]pyrimidin-5-yl)-2,4-dichlorobenzoate; N—[C-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]-N-(4-methylanilino)carbonimidoyl]imino-4-methylbenzamide; Gelcohol; Curcumin; Tirandamycin; Noscapine; Aristolochic acid; Himbacine; Fumagillin; Fumitremorgin C; Physalin B; derivatives, or salt thereof, for use in bone growth processes. In a typical embodiment, a bone graft composition is implanted in a subject at a site of desired bone growth or enhancement. In certain embodiments, compounds disclosed herein are useful for managing obesity and diabetes or other metabolic syndromes by modulation of brown fat. | 2015-05-28 |
20150148293 | FIBROBLAST GROWTH FACTOR MUTANTS HAVING IMPROVED FUNCTIONAL HALF-LIFE AND METHODS OF THEIR USE - Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided. | 2015-05-28 |
20150148294 | Neuroendocrine Tumor Treatment - A method for treating endocrine tumors by administration of an mTOR inhibitor, optionally in combination with another drug. | 2015-05-28 |
20150148295 | Controlled-Released Peptide Formulations - Described herein are methods and compositions for modulating the release and/or drug loading characteristics of encapsulated bioactive agents in polymer-based delivery systems via direct modification of the isoelectric point and/or net charge of the bioactive agent. | 2015-05-28 |
20150148296 | AGENT FOR PROPHYLACTIC AND/OR THERAPEUTIC TREATMENT OF PERIPHERAL NEUROPATHIC PAIN CAUSED BY ANTICANCER AGENT - A medicament effective for prophylactic and/or therapeutic treatment of a peripheral neuropathic pain such as allodynia caused by a treatment with an anticancer agent, which comprises thrombomodulin as an active ingredient. | 2015-05-28 |
20150148297 | OLEANOYL PEPTIDE COMPOSITION AND COLLAGEN ENHANCEMENT - Disclosed is the a method of skin repair and firming, said method comprising the step of bringing into contact a pentapeptide conjugate of oleanolic acid with skin cells so that the effect of increased cellular communication at the molecular level to bring about gene and protein expression in the cells of the skin that enable repair and firming is realized. The invention demonstrates the effect of the pentapeptide conjugate of oleanolic acid in increasing Transforming Growth Factor-β and Fibroblast Growth Factor gene expressions in the skin. | 2015-05-28 |
20150148298 | N-CARBOXYALKYL-AURISTATIN AND USE THEREOF - The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures. | 2015-05-28 |
20150148299 | TOPICAL FORMULATIONS AND USES THEREOF - Provided herein include formulations for topical administration, such as ophthalmic formulations, and methods of using such formulations. In some aspects and embodiments the formulations may include a polyoxyl lipid or fatty acid, and or a polyalkoxylated alcohol and may include nanomicelles. Also include methods of treating or preventing diseases or conditions, such as ocular diseases or conditions. | 2015-05-28 |
20150148300 | METHOD AND PHARMACEUTICAL COMPOSITION FOR HAIR GROWTH - The present disclosure relates to a method and a pharmaceutical composition for hair growth. The pharmaceutical composition includes a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1. The method includes administering a hair growth peptide (HGP) which includes all or part of the amino acid sequence SEQ ID No: 1 to a party of interest. | 2015-05-28 |
20150148301 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF - The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumour-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit. | 2015-05-28 |
20150148302 | Peptide Inhibitors of Caspase 2 Activation - The present invention relates to compositions, including membrane permeable complexes, comprising a Caspase 2 activation inhibitory peptide having the amino acid sequence AFDAFC as well as methods of using the same for the treatment of neurodegenerative conditions associated with apoptosis in the central nervous system, such as Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, amyotrophic lateral sclerosis, Huntington's chorea, and Creutzfeld-Jacob disease. | 2015-05-28 |
20150148303 | PEPTIDES EFFECTIFE IN THE TREATMENT OF CONDITIONS REQUIRING THE REMOVAL OR DESTRUCTION OF CELLS - The embodiments are directed to peptides, compositions, and methods of treating conditions requiring removal or destruction of harmful or unwanted cells in a patient, such as benign and malignant tumors, using compounds containing or based on peptides. | 2015-05-28 |
20150148304 | Novel Peptides and Analogs for Use in the Treatment of Macrophage Activation Syndrome - Innate Defense Regulators (IDRs) interact with intracellular signaling events and modulate the innate defense response. Whereas much of the initial work with the IDRs focused on their role in fighting infection, recent results in animal models of chemotherapy- or radiation-induced mucositis and wound healing suggest that IDRs can be beneficial during the responses to a broader range of damage-inducing agents beyond pathogens. RIVPA (SEQ ID NO. 5), has demonstrated safety in humans and efficacy in animal models of fractionated radiation-induced and chemotherapy-induced oral mucositis, in models of chemotherapy induced damage to the gastro-intestinal tract and in models of local and systemic Gram-positive and Gram-negative infection in immunocompetent and immunocompromised hosts. Based on this information, we propose the use of RIVPA (SEQ ID NO. 5) and/or other IDRs (Table 1) as a novel treatment for Macrophage Activation Syndrome. | 2015-05-28 |