19th week of 2016 patent applcation highlights part 34 |
Patent application number | Title | Published |
20160131569 | Methods For Assessing Cancer Cells Using Granulometry - A method of measuring a characteristic optionally a clinical characteristic of a cancer test cell sample comprising: characterizing nuclear organization of DNA of the test cell sample: obtaining DNA image data of the cancer test cell sample nuclei using microscopy, processing the image data using granulometry to obtain one or more data points corresponding to DNA occupied space and/or DNA low space; and quantifying a feature of the DNA occupied space and/or a feature of the DNA low space. | 2016-05-12 |
20160131570 | EROSION TEST APPARATUS, ACCELERATOR AND EROSION TEST METHOD - An erosion test apparatus includes a combustor configured to obtain a combustion gas by mixing and combusting compressed air and a fuel, and an erodent supply unit configured to supply an erodent to the combustion gas. The erosion test apparatus further includes an accommodation support unit configured to accommodate and support a test piece having a front surface coated through thermal barrier coating, and an accelerator configured to accelerate the combustion gas including the erodent to collide with the test piece. | 2016-05-12 |
20160131571 | ACCELERATED LIFE TESTING DEVICE AND METHOD - An accelerated life testing device and method including an accelerated life testing method for a test piece within a test chamber, the method including: establishing a first atmosphere within the test chamber; changing the first atmosphere to a second atmosphere to form a deposition layer on the test piece; changing the second atmosphere to the first atmosphere to remove the deposition layer from the test piece; and repeating the changing the first atmosphere to the second atmosphere and the changing the second atmosphere to the first atmosphere to form an oxidation layer on the test piece. | 2016-05-12 |
20160131572 | Syringe and Optical Reader for Syringe - The present invention relates to a syringe ( | 2016-05-12 |
20160131573 | TESTING EQUIPMENT WITH MAGNIFYING FUNCTION - A testing equipment with a magnifying function includes a carrier, a cover and a magnifying part. The carrier has a specimen holding area formed on the top of the carrier. The cover is stacked on the specimen holding area of the carrier. The magnifying part disposed on the cover. The location of the magnifying part is corresponding to the location of the specimen holding area. The testing equipment of the present application has a simplified and cheap structure for a simple specimen testing. | 2016-05-12 |
20160131574 | METHOD FOR SCREENING VITAMIN D INSUFFICIENCY USING SKIN COLOURIMETRY - The present application provides a method for establishing a protocol for screening vitamin D (vit-D) insufficiency in a population of interest, a method for screening Vit-D insufficiency using the protocol, and a device for screening Vit-D insufficiency developed based on the protocol. | 2016-05-12 |
20160131575 | METHOD AND SYSTEM FOR MONITORING THE QUALITY OF FLUIDS - A method and system for monitoring the quality of fluids, wherein comprising the different features of a fluid with at least two different methods are measured and a measure for the quality of the fluid is derived and/or a process of the fluid deterioration is identified by comparing the results of the measurements of the at least two different methods, where the methods includes at least one optical absorption measurement and at least one electron paramagnetic resonance measurement. | 2016-05-12 |
20160131576 | Infrared Detection and Imaging Device With No Moving Parts - A device images radiation from a scene. A detector is sensitive to the radiation in a first wavelength band. A lens forms an image of the scene on the detector. A filtering arrangement includes two sets of radiation absorbing molecules. A control unit switches the filtering arrangement between two states. In the first state, all of the radiation in the first wavelength band is transmitted to the detector. In the second state, the radiation in a second wavelength band within the first wavelength band is absorbed by the radiation absorbing molecules. The control unit synchronizes the switching of the filtering arrangement with the detector. Each pixel of the image formed on the detector includes two signals. The first signal includes information from the scene radiation in the first wavelength band. The second signal excludes information from the scene radiation absorbed by the filtering arrangement in the second wavelength band. | 2016-05-12 |
20160131577 | DETECTION OF INDICATIONS OF PSYCHOACTIVE COMPONENTS IN A LIQUID - A method of contactless detection of indications of psychoactive components in a liquid and an apparatus therefor, by emitting a substantially monochromatic light at least at two different wavelengths and detecting the reflection in a free surface of the liquid by a photo detector, analyzing an output signal from the photo detector to identify output parts caused by light emitted from the first and second emitters, respectively, and determining whether the liquid contains at least one psychoactive component. | 2016-05-12 |
20160131578 | SYSTEM AND METHOD FOR SIMULTANEOUS MEASUREMENT OF TURBIDITY, COLOR AND CHLORINE CONTENT OF A SAMPLE OF A LIQUID - A method for measuring turbidity, chlorine content and color of a liquid, the method including retaining, from a continuous flow of the liquid, a sample volume of the liquid, and at least nearly simultaneously executing at least two of detecting illumination from the sample volume of liquid by at least a first detector operable for detecting illumination from the sample volume of liquid at a 90-degree angle with respect to an illumination beam generated by an illuminator and impinging on the sample volume of liquid, thereby measuring a turbidity of the sample volume of liquid. | 2016-05-12 |
20160131579 | ADHERING DETECTION APPARATUS, ADHERING SUBSTANCE DETECTION METHOD, STORAGE MEDIUM, AND DEVICE CONTROL SYSTEM FOR CONTROLLING VEHICLE-MOUNTED DEVICES - An adhering detection apparatus includes a light source to emit probe light to a light translucent object during an emission period, and to stop an emission of the probe light to the light translucent object during a non-emission period, a light receiver to receive light coming from the light translucent object during the emission period and the non-emission period of the light source, and an adhering detection processor to perform an adhering detection processing for detecting a substance adhering to the light translucent object based on light quantity of the light coming from the light translucent object and received by the light receiver, and to output a detection result of the adhering detection processing. The adhering detection processor selectively performs one or more processes depending on the light quantity of the light received by the light receiver during the non-emission period of the light source. | 2016-05-12 |
20160131580 | OPTICAL ANALYTE SENSOR - A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved. | 2016-05-12 |
20160131581 | IN-SITU ON-LINE DETECTION DEVICE AND METHOD FOR LONG-DISTANCE METALLURGICAL LIQUID METAL COMPONENT - An in-situ on-line detection device and detection method for a long-distance metallurgical liquid metal component. The detection device comprises a front-end high-temperature resistant probe ( | 2016-05-12 |
20160131582 | GOLD NANOCLUSTER COMPOSITION AND METHOD FOR PREPARING THE SAME AND METHOD FOR DETECTING THIOL-CONTAINING COMPOUNDS - A gold nanocluster composition and method for preparing the same are provided. The method includes providing a gold ion-containing solution. Next, the method entails mixing the gold ion-containing solution and a reducing agent solution to obtain a first mixture liquid, and heating the first mixture liquid to obtain a second mixture liquid, wherein the second mixture liquid contains the gold nanoclusters, which are partially capped by reducing agent. | 2016-05-12 |
20160131583 | FLUORESCENCE IMAGING SYSTEM FOR TISSUE DETECTION - An imaging system ( | 2016-05-12 |
20160131584 | Compositional Analysis Of A Gas Or Gas Stream In A Chemical Reactor and Method For Preparing Chlorosilanes In A Fluidized Bed Reactor - The composition of a gas or gas stream containing AlCl | 2016-05-12 |
20160131585 | METAMATERIAL DEVICE AND USES THEREOF - The present invention relates to a logic gate, comprising a metamaterial surface enhanced Raman scattering (MetaSERS) sensor, comprising (a) alphabetical metamaterials in the form of split ring resonators operating in the wavelength range of from 560 to 2200 nm; and (b) a guanine (G) and thymine (T)-rich oligonucleotide that can, upon presence of potassium cations (K | 2016-05-12 |
20160131586 | HEROIN DETECTION BY RAMAN SPECTROSCOPY FROM IMPURE COMPOSITIONS COMPRISING AN INTERFERING FLUORESCENT CONTAMINANT - A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided. | 2016-05-12 |
20160131587 | Method and Apparatus for Monitoring Pulsed Plasma Processes - Emitted light from a pulsed plasma system is detected, amplified and digitized over a plurality of pulse modulation cycles to produce a digitized signal over the plurality of RF modulation periods, each of which contains an amount of random intensity variations. The individual signal periods are then mathematically combined to produce a stable local reference waveform signal that has decreased random intensity variations. One mechanism for creating a stable local reference waveform signal is by subdividing each of the individual signal periods into a plurality of subunits and the mathematically averaging the respective subunits within the modulation period to produce the stable local reference waveform signal for the modulation period. The stable local reference waveform signal can then be compared to other instantaneous waveform signals from the pulsed plasma system, or waveform parameters can be derived using various signal processing techniques such as Fourier analysis. | 2016-05-12 |
20160131588 | DEGRADABLE CATIONIC SURFACTANTS AND USE THEREOF IN ENHANCING CHEMILUMINESCENCE - The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants. | 2016-05-12 |
20160131589 | Optical Sensor Element for Analyte Assay in a Biological Fluid, and Method of Manufacture Thereof - Beginning with a sheet of optically transparent material, one may fabricate a great many shaped optical wafers, each in the form of a thin and essentially flat piece of optical material having a narrow cross-sectional width relative to length, and a sharply narrowed tip at one end. The fabrication process involves passing a sheet of optically transparent material through one or more operational steps wherein cutting, shearing, embossing, microperforating, or a combination thereof is performed. The fabrication process may further include a cladding operation, a tip texturing operation, and an analyte-reactive reagent deposition operation. The completed optical wafers are separated and each may be mounted into a user-operated device along with systems for educing a fluid sample to be expressed from a living organism, for bringing the tip of the optical wafer into contact with the fluid sample, and for illuminating and assaying the fluid sample. | 2016-05-12 |
20160131590 | BIOCHIP FOR MEASURING BLOOD GLUCOSE LEVELS, AND BLOOD GLUCOSE METER FOR SMARTPHONE, CONTAINING SAME - Disclosed are a biochip for measuring blood glucose levels and a blood glucose meter for a smartphone including the same. The biochip for measuring blood glucose levels includes: a substrate, one surface of which is provided with a blood glucose inflow region into which blood glucose flows and with a reaction region that is connected to the blood glucose inflow region and has a recess formed therein, a porous separator disposed on the blood glucose inflow region to face the surface of the substrate, and silica nanoparticles and a reaction reagent distributed on the reaction region of the substrate. Thereby, blood glucose levels can be measured using such a biochip, which is easy to carry, together with a CMOS image sensor, and particularly, blood glucose levels can be simply measured using a CMOS image sensor provided to a smartphone, and blood glucose levels can be quantitatively measured and checked using a blood glucose meter application installed on a smartphone. | 2016-05-12 |
20160131591 | COLIPHAGE BIOSENSOR - Disclosed are methods, apparatuses, and genetically modified bacteria that may be used to detect bacteriophages in a sample. In some embodiments, a rapid detection test is disclosed to test for the presence of coliphages which may indicate the presence of human or animal waste contamination in water samples. | 2016-05-12 |
20160131592 | MODULAR ILLUMINATION AND SENSOR CHAMBER - Embodiments described are generally directed to a test sample apparatus. The test sample apparatus generally comprises a holder base arranged that accommodates a tablet or cell phone. The apparatus has a hood that is placed over a portion of the tablets illuminating touchscreen such that the illuminating touchscreen provides light that can be collected by the hood. There is a chamber integrated with the hood adapted to accommodate a chemically activated test strip. The chemically activated test strip is illuminated when the hood collects light from the illuminating touchscreen. A lens in the hood interposed between the camera and the test strip enables the camera to focus on a portion of the chemically activated test strip when the hood is placed over the portion of the illuminating touchscreen. | 2016-05-12 |
20160131593 | SURFACE INSPECTION APPARATUS AND METHOD, AND METHOD OF MANUFACTURING DISPLAY DEVICE - A surface inspection apparatus and method, and a method of manufacturing a display device are disclosed. In one aspect, the surface inspection method includes placing an object on a stage comprising a top surface inclined at a predetermined angle with respect to a plane having a first direction and a second direction crossing the first direction. The method also includes irradiating light onto the object via a surface inspection unit. The method also includes obtaining a first image comprising first interference fringes captured by the imaging device, moving at least one of the surface inspection unit and the stage in at least one of the first and second directions, obtaining a second image including second interference fringes captured by the imaging device, and moving the surface inspection unit in the third direction so as to correct movement of the second interference fringes with respect to the first interference fringes. | 2016-05-12 |
20160131594 | SYSTEMS FOR PARSING MATERIAL PROPERTIES FROM WITHIN SHG SIGNALS - Semiconductor metrology systems based on directing radiation on a wafer, detecting second harmonic generated (SHG) radiation from the wafer and correlating the second harmonic generated (SHG) signal to one or more electrical properties of the wafer are disclosed. The disclosure also includes parsing the SHG signal to remove contribution to the SHG signal from one or more material properties of the sample such as thickness. Systems and methods described herein include machine learning methodologies to automatically classify obtained SHG signal data from the wafer based on an electrical property of the wafer. | 2016-05-12 |
20160131595 | MINIATURE AIR GAP INSPECTION CRAWLER - A system for inspecting a dynamoelectric machine is provided. The dynamoelectric machine includes a rotor, a stator and a radial gap existing between the rotor and the stator. The system includes a sled configured for insertion into the radial gap between the rotor and the stator. The sled is configured to transport an optical device along the radial gap. The optical device obtains an image of the radial gap, a portion of the rotor and a portion of the stator. The sled is configured for attachment to a push rod and the push rod is used to move the sled and optical device along the radial gap. The system is configured for entry into a single end of the dynamoelectric machine. | 2016-05-12 |
20160131596 | OIL DETECTION PROCESS AND APPARATUS - A process for detecting oil or lubricant contamination in a manufactured product, the process comprising adding a fluorescent taggant to oils or lubricants contained in processing machinery for said product, conveying said product past an infrared detection apparatus, irradiating said product with infrared radiation from said detection apparatus as it passes the detection apparatus, and detecting infrared radiation emitted from said irradiated product. | 2016-05-12 |
20160131597 | An Optical Device for Detecting Quality of Welding Gun Electrodes - An optical device for detecting quality of welding gun electrodes An optical sensor device comprises a housing ( | 2016-05-12 |
20160131598 | DETECTION SYSTEM FOR DETECTING A SOLDERED JOINT - The invention relates to a detection system ( | 2016-05-12 |
20160131599 | METHOD OF EVALUATING RELIABLE LIFE SPAN OF ENCAPSULANT FILM AND DEVICE FOR EVALUATING RELIABILITY OF SAID FILM - There are provided a method of evaluating a reliable lifespan of an encapsulant film and a device for evaluating reliability of the film. The present application may provide a film that may be provided for an evaluation method in which reliability of an encapsulant film is simply and easily evaluated only by measuring a haze immediately before the encapsulant film is used, a failure of a product is determined and reliability may be predicted. | 2016-05-12 |
20160131600 | APPARATUS AND TECHNIQUES FOR FOURIER TRANSFORM MILLIMETER-WAVE SPECTROSCOPY - Examples herein include apparatus and techniques that can be used to perform rotational spectroscopy on gas-phase samples. Such techniques can include using a spectrometer providing frequency synthesis and pulse modulation to provide excitation (e.g., pump or probe pulses) of a gas-phase sample at mm-wave frequencies. Synthesis of such mm-wave frequencies can include use of a frequency multiplier, such as an active multiplier chain (AMC). A free induction decay (FID) elicited by the excitation or other time-domain information can be obtained from the sample, such as down-converted and digitized. A frequency domain representation of the digitized information, such as a Fourier transformed representation, can be used to provide a rotational spectrum. | 2016-05-12 |
20160131601 | SYSTEM AND METHOD TO MEASURE SALINITY OF MULTI-PHASE FLUIDS - A method of determining salinity of multi-phase fluids in a conduit includes exciting a sensing device to cause emission of electromagnetic waves of one or more frequencies into the multi-phase fluid. The method includes receiving transmitted or reflected electromagnetic waves from the multi-phase fluid. Furthermore, the method includes determining an intermediate parameter from the received electromagnetic waves. The method also includes obtaining estimated values of a plurality of parameters from the intermediate parameter. The estimated values comprise at least one of an estimated value of conductance, an estimated value of susceptance, an estimated value of differential conductance, an estimated value of differential susceptance, an estimated value of a real part of complex permittivity, and an estimated value of an imaginary part of complex permittivity. Salinity of the fluid is determined based, at least in part, on the estimated values of the plurality of parameters. | 2016-05-12 |
20160131602 | Core Sample Analysis - A method and system for analyzing a core sample from a wellbore, where the analysis takes place in the field and proximate the wellbore. The system includes trailers adjacent one another. One of the trailers can include a unit for scanning the core sample and obtaining information within the sample. Other trailers can include units that further analyze the core, such as by grinding, laser spectroscopy, and Raman spectroscopy. The core sample scanning involves a computerized tomography (CT) scan, where a length of core is analyzed in the scanning unit. The unit includes a manipulator system for moving the core sample through a rotating scan source in the scanning unit. | 2016-05-12 |
20160131603 | METHODS OF PREDICTING OF CHEMICAL PROPERTIES FROM SPECTROSCOPIC DATA - A method of predicting of chemical properties from spectroscopic data is described. The chemical property can be, for example, octanol-water partition coefficient (logP), skin permeability (log K,), or other biologically or ecologically relevant property, such as oral bioavailability, skin sensitization, acute aquatic toxicity, chronic aquatic toxicity, aquatic bioaccumulation, or mutagenicity. The spectroscopic data can be experimental or predicted NMR data, e.g., experimental or predicted | 2016-05-12 |
20160131604 | Thermally Resolved Molecule Assays - Provided herein are compositions and methods including the step of thermally scanning a sample that can be used and implemented to detect the presence of and/or concentration of a molecule in a sample. | 2016-05-12 |
20160131605 | METHOD AND SYSTEM FOR PREDICTING REMAINING USEFUL LIFE OF TRANSPORT UNITS - Methods and systems for predicting a remaining useful life of one or more components of a transport refrigeration system (TRS) are described. The methods and systems described herein generally involve predicting a useful life of a transport unit based on a determined parameter. The determined parameter can be, for example, an ambient temperature, a return air temperature, an internal space temperature and/or a discharge air temperature. | 2016-05-12 |
20160131606 | METHOD FOR AT LEAST QUALITATIVELY DETERMINING AT LEAST ONE PHYSICAL AND/OR CHEMICAL CHARACTERISTIC OF A LAMINATE PANEL - The invention relates to a method for at least qualitatively determining at least one physical and/or chemical characteristic of a laminate panel ( | 2016-05-12 |
20160131607 | METHOD OF COMBINED USE OF INFRARED CAMERA, NON-CONTACT INFRARED SENSOR, OR CONTACT TEMPERATURE SENSOR WITH INSULATION RESISTANCE TESTER FOR AUTOMATIC TEMPERATURE NORMALIZATION - Systems can include a resistance testing device configured to generate resistance data regarding the insulation resistance of equipment under test and a temperature sensing device configured to generate temperature data regarding the temperature of the equipment under test. The system can include a processor configured to receive the resistance data and the temperature data. Based on the received data, the processor can determine normalized resistance data accounting for temperature effects on the measured resistance. Normalized resistance data can indicate a predicted value for the insulation resistance measurement had the measurement been performed at a reference temperature. Thus, insulation resistance values normalized to a common temperature can be more accurately and meaningfully analyzed and trended over time. | 2016-05-12 |
20160131608 | PPM POOL SENSOR - A sensor including first and second electrodes can be used to determine the concentration of at least one chemical constituent in a fluid sample under test. The electrodes can be disposed in the fluid sample and a predetermined voltage can be applied to a first electrode. The voltage can cause a current to flow between the first and second electrodes through the sample, the current dependent on the concentration of the chemical constituent in the fluid sample. A sense resistor is coupled to the first electrode such that the current flowing between the electrodes flows through the sense resistor. A processor electrically isolated from the electrodes can receive data signals indicative of the voltage drop across the sense resistor and the voltage applied at the first electrode. The received signals can be used to determine the concentration of the constituent in the fluid sample. | 2016-05-12 |
20160131609 | CARBON MATERIAL SUPPORTED HOLLOW METAL OXIDE NANOPARTICLES, METHODS AND APPLICATIONS - A method for preparing a material composition comprising a hollow transition metal oxide nanoparticle supported upon a carbon material support includes a solution impregnation process step, followed by a thermal reduction process step and finally a thermal oxidation process step. The material composition, an electrode and an electrical component such as but not limited to a battery are all predicated at least in-part upon the material composition prepared in accord with the foregoing method. The foregoing material composition, electrode, battery and method may ultimately provide a LIB with enhanced performance. | 2016-05-12 |
20160131610 | ELECTROCHEMICAL TEST STRIP, MEASUREMENT SYSTEM AND METHOD FOR DETERMINING SAMPLE CONTENT IN THE REACTIVE REGION OF THE ELECTROCHEMICAL TEST STRIP - An electrochemical test strip, measurement system and method for determining sample content in the reactive region of the electrochemical test strip are presented. The electrochemical test strip comprises an insulator substrate which includes an electrode system disposed thereon. The electrode system includes at least one pair of electrodes. A lower plate which includes a reactive region and a sampling cell is disposed on the insulator substrate. An upper plate is disposed on the lower plate, wherein the at least one pair of electrodes is designed as an electrical loop adjacent to the sampling port. | 2016-05-12 |
20160131611 | ANION SENSOR - The present invention announces a method for extending the storage life of a test reagent for quantification of ionic components in samples by using an anion sensor. The purpose of the present invention is to provide an anion sensor, wherein the storage life of the anion sensor itself may be extended, to thereby extend the storage life of the anion sensor beyond that of conventional anion sensors. According to the present invention, through adjustment of the pH of the internal solution (internal gel liquid), it is possible to provide an anion sensor that maintains consistent performance, and has longer storage life. | 2016-05-12 |
20160131612 | MEASUREMENT OF ION CONCENTRATION IN PRESENCE OF ORGANICS - Disclosed herein are systems and methods that relate to use of ultramicroelectrodes (UME) in measurement of ion concentration in presence of one or more organic compound(s). | 2016-05-12 |
20160131613 | FLOATING GATE BASED SENSOR APPARATUS AND RELATED FLOATING GATE BASED SENOR APPLICATIONS - A floating gate based sensor apparatus includes at least two a separate electrical bias components with respect to a floating gate based sensor surface within the floating gate based sensor apparatus. By including the at least two electrical bias components, the floating gate based sensor apparatus provides enhanced capabilities for biomaterial and non-biomaterial detection and manipulation while using the floating gate based sensor apparatus. | 2016-05-12 |
20160131614 | Dissolved Oxygen Measurement System and Method of Calibrating Dissolved Oxygen Meter - In order to improve measurement accuracy by accurately calibrating sensitivity of a dissolved oxygen meter without impairing easiness in calibration, the present invention includes a dissolved oxygen measuring device that includes a cell to be loaded with a sample solution, and a dissolved oxygen meter that is attached to the cell and measures an oxygen concentration in the sample solution; and a mode switching mechanism to switch between a measurement mode, in which a sensor surface of the dissolved oxygen meter is substantially in contact with the sample solution in the cell, and a calibration mode, in which the sensor surface is substantially not in contact with the sample solution in the cell, by feeding air into the cell through a feed port disposed on the cell, and by discharging part of the sample solution through a discharge port disposed on the cell. | 2016-05-12 |
20160131615 | HIGH PERFORMANCE QUARTZ CRYSTAL MICROBALANCE ENHANCED BY MICROSTRUCTURES FOR BIOLOGICAL APPLICATIONS - Quartz crystal microbalance resonators are described, as are methods of making them using micron sized pillar array of polymethyl methacrylate fabricated on a QCM surface using a nanoimprint lithography process. Their use in any applications, including for example gas and liquid sensors and biosensors as well as other measurement applications, is also discussed. | 2016-05-12 |
20160131616 | LOW POLLUTANT DIALYSIS SOLUTION - The present invention relates to a method for determination of pollutants and leachables in dialysis solutions by stir bar sorptive extraction comprising the steps of
| 2016-05-12 |
20160131617 | LIQUID FLOW RATE MEASUREMENT DEVICE - Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid. A first detector, disposed in a path of the flow of liquid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A second detector, disposed downstream from the first detector in the path of the flow of fluid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A computing system receives each signal produced by the first and second detectors upon detecting the substance in the flow of fluid, and computes a volumetric flow rate of the flow of fluid based on a time interval between the signals and a volume of the path between the first and second detectors. | 2016-05-12 |
20160131618 | Separation and Analysis Systems and Methods - Disclosed is an extraction and analysis system and method. The system comprises a separation apparatus, a liquid-liquid extraction apparatus and an analysis apparatus. The liquid-liquid extraction apparatus is configured to receive a substantially continuous inlet flow of a first liquid from the separation apparatus, the first liquid carrying a mixture of components including an analyte. The liquid-liquid extraction apparatus is operable to receive a second liquid for contact with the first liquid, the second liquid being substantially immiscible with the first liquid. This provides partitioning of the analyte and/or another component carried by the first liquid preferentially into the second liquid substantially continuously. Subsequently the first and second liquids are separated substantially continuously. The system further comprises an outlet flow conduit operable substantially continuously to conduct the analyte, in a corresponding flow of said first or second liquid, to the analysis apparatus for substantially continuous analysis. | 2016-05-12 |
20160131619 | VALVE AND SPLITTING SYSTEM FOR MULTI-DIMENSIONAL LIQUID ANALYSIS - A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into fist and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis. | 2016-05-12 |
20160131620 | ENHANCED SENSITIVITY OF DETECTION IN ELECTROSPRAY IONIZATION MASS SPECTROMETRY USING A POST-COLUMN MODIFIER AND A MICROFLUIDIC DEVICE - A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample. | 2016-05-12 |
20160131621 | ION GENERATION USING MODIFIED WETTED POROUS MATERIALS - The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. | 2016-05-12 |
20160131622 | SENSING DEVICE FOR SPECTROSCOPIC DETECTION OF HYDROGEN PEROXIDE - A sensing device for determining the presence of hydrogen peroxide is disclosed. The sensing device comprises a light guide having a distal portion terminating at a light guide tip and a proximal portion, wherein the light guide tip is proximal to a layer of Prussian blue (PB), which is pure (or essentially free of contaminants). The sensing device produces a fast linear response and is durable, due to the robustness and purity of the PB. The PB is chemically deposited proximal to, or on, the light guide tip using a single-source precursor technique. Methods of making and using the device also are disclosed herein. | 2016-05-12 |
20160131623 | SYSTEMS AND METHODS FOR ANALYZING CONTAMINANTS IN FLOWING ATMOSPHERIC AIR - Optically interacting electromagnetic radiation with a flowing atmospheric air composition and optically interacting the electromagnetic radiation with an integrated computational element (“ICE”), the ICE being configured to analyze for a contaminant in the flowing atmospheric air. A detector receives the electromagnetic radiation that has optically interacted with the flowing atmospheric air and the ICE and generates an output signal corresponding to a characteristic of the contaminant in the flowing atmospheric air. | 2016-05-12 |
20160131624 | CARBON DIOXIDE GROUND LEAKAGE MONITORING SYSTEM - Provided is a carbon dioxide ground leakage monitoring system that is low cost, capable of real-time multi-point monitoring on a wide scale, and capable of providing the public with easy-to-understand information. | 2016-05-12 |
20160131625 | UNIVERSAL DETECTOR CALIBRANT - A method of calibrating a biological detector can include training a biological detector to detect a calibration compound, wherein the calibration compound comprises an odor that is detectable by the biological detector and is not used in an environment for which the biological detector is trained to detect odors, presenting the biological detector with a device comprising the calibration compound, and determining whether the biological detector will alert to the calibration compound. | 2016-05-12 |
20160131626 | METHODS FOR TRACING FLUID MIGRATION - The disclosure relates to application of a signature elemental tracer referred to herein as a signature). It comprises a selection of a small amount of a unique combination of a non-radioactive isotope or variant of a particular element or elements with stable isotopes, different from the natural-occurring combination of the elements in question. In particular, there are 54 such stable multi-isotopic elements and 17 rare-earth elements available for the creation of signature. The signature can be chosen based on samples of traced material and the environment it is to be used in, over time based on detectability, duration, and robustness in that environment. By utilizing isotope combinations as a signature, one can readily determine with a mass spectrometer, whether the traced material in question was or was not in a particular sample of contamination, plant tissue, animal tissue, or associated with some event of interest. | 2016-05-12 |
20160131627 | REACTION CARRIER, MEASURING SYSTEM AND MEASURING METHOD FOR DETERMINING GAS AND PARTICLE CONCENTRATIONS, AND OPTICAL FLOW SENSOR - A measuring system ( | 2016-05-12 |
20160131628 | METHOD OF CLAY STABILIZATION ANALYSIS - A method of evaluating stabilization fluids for use in a subterranean formation having a clay composition is disclosed. The method features providing a plurality of replicant core samples representative of the composition of a subterranean formation. A plurality of stabilization fluids are introduced to the plurality of replicant core sample such that an eluted mixture is extracted from a second end of each replicant core sample. Afterwards, at least one property of the eluted mixture from each replicant core sample is determined. | 2016-05-12 |
20160131629 | METHOD FOR DETECTING OIL ON TOBACCO PRODUCTS AND PACKAGING - A process for detecting oil or lubricant contamination in a manufactured product, the process comprising adding at least two fluorescent taggants to oils or lubricants contained in processing machinery for said product, irradiating said product, causing at least one of said taggants to fluoresce and detecting radiation emitted by said fluorescing taggant in an oil-contaminated product. | 2016-05-12 |
20160131630 | Methods and Systems for Correction of Oil-Based Mud Filtrate Contamination on Saturation Pressure - Embodiments of the disclosure can include systems, methods, and devices for determining saturation pressure of an uncontaminated fluid. Downhole saturation pressure measurements and downhole OBM filtrate contamination of a contaminated fluid may be obtained and a relationship may be determined between the saturation pressure measurements and OBM filtrate contamination. The relationship may be extrapolated to zero OBM filtrate contamination to determine the saturation pressure of the uncontaminated fluid. In some embodiments, OBM filtrate contamination may be determined from downhole saturation pressure measurements during pumpout of a fluid. | 2016-05-12 |
20160131631 | Method for Characterizing the Hydrocarbon Content of a Reformate Stream - Method for characterizing the hydrocarbon content of a reformate sample stream. Water and ammonia are removed from the sample stream and the hydrocarbon content is measured using a chemical component analyzer. | 2016-05-12 |
20160131632 | Apparatus, Method and System for Detecting Salt in a Hydrocarbon Fluid - A method for determining a salt concentration of a hydrocarbon fluid using a conductivity sensor and a hydrocarbon testing solution includes forming the hydrocarbon testing solution. The electropolymerizable monomer is operable to form a resultant associated polymer at a peak potential of the electropolymerizable polymer. The method includes introducing the hydrocarbon testing solution into the conductivity sensor. The method includes inducing a range of potential across the hydrocarbon testing solution such that at least a portion of the electropolymerizable monomer polymerizes. The range of induced potential includes the peak potential of the electropolymerizable polymer. The method includes detecting a range of electrical current associated with the range of potential induced. The method also includes the step of determining the salt concentration of the hydrocarbon fluid using the range of potential induced and the range of electrical current detected. | 2016-05-12 |
20160131633 | DEVICE AND METHOD FOR DETERMINING THE TEMPERATURE OF A ROAD BUILDING MATERIAL APPLIED BY A CONSTRUCTION MACHINE, AND CONSTRUCTION MACHINE COMPRISING SUCH A DEVICE - A device for determining the temperature of a road building material applied by a construction machine in a mounting width is arranged at the construction machine in a range within the mounting width and has an infrared temperature measuring head, a motor and a controller, the infrared temperature measuring head being arranged to be twistable by the motor transverse to the direction of travel of the construction machine and being effective to record temperature measuring values of the surface of road building material during a rotational movement at at least two measuring points spaced apart from one another. The controller is effective to control the motor based on the fitting position of the device at the construction machine such that the distance between the measuring points on the surface to be measured remains equal. | 2016-05-12 |
20160131634 | METHODS OF EVALUATING CELL CULTURE ADDITIVES - The present disclosure shows, unexpectedly, that variations in cell culture performance in large-scale cell culture systems such as, for example, those used in commercial manufacturing processes, in some instances, can be attributed to often subtle variations among shear-protectant additives used during cell culture. Assessing the quality of shear-protective additives using such large-scale systems, however, is inaccurate, time-consuming and costly. To solve the problem identified, the present disclosure provides methods and compositions for evaluating the suitability of shear-protectant additives without resorting to large scale cell growth and/or protein production tests. | 2016-05-12 |
20160131635 | CELL ANALYSIS BY MASS CYTOMETRY - A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells. | 2016-05-12 |
20160131636 | SYSTEM AND METHOD FOR HIGH-THROUGHPUT ASSESSMENT OF CELLULAR CARDIOTOXICITY, DRUG SCREENING, AND CARDIOGENIC FACTORS VIA ONLINE PHYSIOLOGICAL MEASUREMENTS - An integrated system for detecting safety and/or efficacy issues related to potential drug compounds by combining tissue maturation, imaging and electrophysiology measurements, at high throughput, with high signal to noise ratio. Testing includes cardiotoxicity screening, drug screening, and screening for cardiogenic factors via on-line physiological measurements. | 2016-05-12 |
20160131637 | SUSPENDED NANO-ELECTRODES FOR ON-CHIP ELECTROPHYSIOLOGY - A microfluidic device includes a first microfluidic channel comprising a side wall and an electrode, disposed on the side wall. The microfluidic device further includes an intersection of the first microfluidic channel and a second microfluidic channel proximate to the electrode. The electrode is suspended into an interior region of the first microfluidic chamber. | 2016-05-12 |
20160131638 | IMMUNITY TO FOLATE RECEPTORS - This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FRα immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors. | 2016-05-12 |
20160131639 | NOVEL ANTIGEN BINDING PROTEIN AND ITS USE AS ADDRESSING PRODUCT FOR THE TREATMENT OF CANCER - The present invention relates to a novel antigen binding protein, in particular a monoclonal antibody, capable of binding specifically to the protein Axl as well as the amino and nucleic acid sequences coding for said protein. From one aspect, the invention relates to a novel antigen binding protein, or antigen binding fragments, capable of binding specifically to Axl and, by inducing internalization of Axl, being internalized into the cell. The invention also comprises the use of said antigen binding protein as an addressing product in conjugation with other anti-cancer compounds, such as toxins, radio-elements or drugs, and the use of same for the treatment of certain cancers. | 2016-05-12 |
20160131640 | MICROFLUIDIC DEVICE - Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples. | 2016-05-12 |
20160131641 | COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF - This invention provides compound having a structure of Formula I: | 2016-05-12 |
20160131642 | GRATING PATTERN ELEMENT, TARGET MATERIAL MEASURING APPARATUS, AND TARGET MATERIAL MEASURING METHOD - A grating pattern element includes peaks which are periodically arranged and valleys provided between the peaks, and at least one of the peaks and at least one of the valleys includes an adsorbing material on a surface thereof which adsorbs a target material. | 2016-05-12 |
20160131643 | MICROFLUIDIC COLLABORATIVE ENZYME ENHANCED REACTIVE CEER IMMUNOASSAY - The present invention provides methods for diagnosing a disease state in a patient by detecting the presence, expression level and/or activation level of a target analyte in a patient sample using a proximity dual detection assay on a microcarrier. The present invention also provides an assay device for performing the methods described herein. | 2016-05-12 |
20160131644 | METHOD FOR DETECTION OF PROTEIN COMPRISING HISTIDINE-TAG USING IMMUNOCHROMATOGRAPHY - The present invention relates to a method for the detection of a protein including a histidine-tag using immunochromatography. The detection method of the present invention uses immunochromatography using the polymer particle fixed with the histidine-tag, wherein a histidine-tag specific antibody alone is used to detect a histidine-tag conjugated protein (recombinant protein) quickly without using a target protein specific antibody. This method is also efficient in detecting and quantifying the histidine-tagged protein included in the sample without using an additional apparatus but quickly and accurately. | 2016-05-12 |
20160131645 | Rapid Lateral Flow Assay Method for Low Quantity Liquid or Dry Samples - This invention describes a device for assaying a dry or small volume liquid sample on a lateral flow capillary assay by utilizing a supplementary non-sample aqueous solution that will push the sample up the assay without diluting or significantly diluting the original sample. This invention enables a sample to be assayed rapidly and/or on-site when the sample is in dried or solid form, or when the liquid volume is too small to complete an assay. As an option, the device can display a colored signal when a sufficient amount of liquid sample has been collected or added to the device. The minimal liquid volume requirement of the device significantly reduces the sample collection time to a matter of seconds and resolves situations in which fluids available for collection are not abundant. Therefore, this invention allows the lateral flow test device to be a more rapid, efficient, and versatile apparatus. | 2016-05-12 |
20160131646 | DETECTION AND TREATMENT OF AUTOIMMUNE DISORDERS - Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand. | 2016-05-12 |
20160131647 | REGULATORY BRAIN SPECIFIC CYTOPLASMIC RNAS (BC RNAs) AND METHODS OF USE THEREOF IN DIAGNOSIS AND TREATMENT OF NEUROPSYCHIATRIC LUPUS - Compositions and methods for diagnosing an increased risk of NPSLE are provided. | 2016-05-12 |
20160131648 | ALKYL QUINOLONES AS BIOMARKERS OF PSEUDOMONAS AERUGINOSA INFECTION AND USES THEREOF - A method of determining the | 2016-05-12 |
20160131649 | MICROBIAL GLYCANS AS A TARGET OF HUMAN INTELECTIN - The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including | 2016-05-12 |
20160131650 | VIRUS-DETECTION KITS AND METHODS OF MAKING AND USING THE SAME - The present disclosure relates to compositions, kits, and methods for the detection of a virus in a sample. Typically, the sample is from a subject suspected of, exhibiting symptoms of, or previously diagnosed with a viral infection, such as an Ebola virus. | 2016-05-12 |
20160131651 | Gamma-Secretase Substrates and Methods of Use - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 2016-05-12 |
20160131652 | Method for Determining The Endotoxin Content of An Aluminum Salt Preparation - The present invention provides methods for determining the endotoxin content of an aluminium salt for use in medicine, comprising the steps of:
| 2016-05-12 |
20160131653 | SUBJECT ANIT-HCV ANTIBODY DETECTION ASSAYS EMPLOYING NS3 CAPTURE PEPTIDES - The present disclosure provides methods, kits, and compositions for detecting subject anti-HCV antibodies in a sample using NS3 capture peptides. In certain embodiments, at least two NS3 helicase (NS3h) capture peptides and at least two conjugate peptides (e.g., NS3h conjugate peptides) are employed together, which allows for a broad dynamic range of subject antibody detection in a one-step type assay. In other embodiments, methods are provided of detecting NS3-specific subject antibodies without the use of a reducing agent. In some embodiments, NS3-specific subject antibodies are detected with a ‘double shot’ of NS3 conjugate peptide (e.g., conjugate peptide added to a sample both before and after washing). | 2016-05-12 |
20160131654 | DIAGNOSTIC, PROGNOSTIC, AND MONITORING METHODS FOR MULTIPLE MYELOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, AND B-CELL NON-HODGKIN LYMPHOMA - The invention generally provides improved compositions and methods for detecting, diagnosing, prognosing, and monitoring multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in a subject. In particular, the invention provides methods for detecting BCMA in subjects to reliably diagnose, predict survival, or monitor multiple myeloma, chronic lymphocytic leukemia, or B-cell non-Hodgkin lymphoma in the subject. | 2016-05-12 |
20160131655 | BCMA-BASED STRATIFICATION AND THERAPY FOR MULTIPLE MYELOMA PATIENTS - The present invention relates to methods for the stratification of a multiple myeloma (MM) patient comprising determining whether or not B-cells, preferably malignant B-cells of said patient express BCMA protein on their surface. Also, methods for selecting an antibody-based multiple myeloma (MM) therapy is based on whether or not BCMA is expressed on the cell surface of B-cells, preferably malignant B-cells of a patient. Furthermore, antibody-based therapies for patients who have BCMA positive malignant B-cells are provided. | 2016-05-12 |
20160131656 | TUMOR MARKER, MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - Newly identified proteins as markers for the detection of colon, ovary, kidney, esophagus and prostate tumors, or as therapeutic targets for their treatment; affinity ligands and particularly antibodies capable of selectively interacting with the tumor markers and methods for tumor diagnosis and thereapy using such antibodies. | 2016-05-12 |
20160131657 | Methods and Compositions for the Diagnosis and Treatment of Cancer - The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer. | 2016-05-12 |
20160131658 | METHOD AND KIT FOR ASSESSING VIABLE CELLS - The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM). | 2016-05-12 |
20160131659 | FLUORINATED POLYMER DOTS - This disclosure provides semiconducting polymer dots (Pdots) for use in a wide variety of applications. In particular, this disclosure provides Pdots that are halogenated, including fluorinated Pdots. This disclosure also provides methods for synthesizing Pdots and methods for using Pdots, such as for biological imaging. | 2016-05-12 |
20160131660 | Risk Stratification for Acute Coronary Syndrome by Means of Fragments/Partial Peptides of Provasopressin, Especially Copeptin or Neurophysin II - The invention relates to a method for risk stratification for acute coronary syndrome (ACS), in particular acute myocardial infarction (AMI) and angina pectoris (AP), wherein provasopressin (proAVP) or fragments and partial peptides thereof, in particular copeptin or neurophysin II, is determined by an in vitro diagnosis. | 2016-05-12 |
20160131661 | PHOSPHORYLCHOLINE CONJUGATES AND CORRESPONDING ANTIBODIES - In subjects with hypertension, increases in intima-media thickness (IMT) at four years were less in subjects also having high autoantibodies particularly IgM, to phosphorylcholine. The presence or absence of autoantibodies, particularly IgM, against phosphrylcholine is thus related to an increased or decreased risk of developing ischemic cardiovascular diseases. A method to determining antibodies, particularly IgM antibodies, toward phosphorylcholine is proposed in this invention to identify subjects at risk of developing ischemic cardiovascular diseases. Animal experiments show that medium to high levels of antibodies, particularly IgM antibodies, can be detected in plasma after active immunization with a keyhole limpet hemocyanin (KLH)-phosphorylcholine conjugate. Pharmaceutical compositions comprising a phosphorylcholine conjugate or antibody preparations, for example a monoclonal antibody, with specificity to a phosphorylcholine conjugate is proposed as is use of these compositions as active or passive immunogens in the treatment or prevention of atherosclerosis. | 2016-05-12 |
20160131662 | PROTEIN AND ANTIBODY PROFILING USING SMALL MOLECULE MICROARRAYS - Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a tool for monitoring the state of the immune system of a patient. This may be a generally useful tool for the diagnosis of many types of disease states. Similar techniques are employed to detect the post-translational modification of specific proteins, a tool for the visualization of induction of signal transduction pathways in cells and tissues treated with drugs. Finally, aspects of the invention teach a method for the creation of simpler arrays with less than 100 features that are, nonetheless, effective for protein profiling experiments. | 2016-05-12 |
20160131663 | BIOMARKER FOR PSYCHIATRIC AND NEUROLOGICAL DISORDERS - The purpose of the present invention is to provide: a biomarker for psychiatric and neurological disorders, in particular, a biomarker for diagnosing psychiatric and neurological disorders; and a test kit and test method for psychiatric and neurological disorders. The inventors discovered that there is a significant increase in the concentration of free κ immunoglobulin chains and free λ immunoglobulin chains in the blood samples from patients with psychiatric and neurological disorders. Consequently, the present invention provides a biomarker for psychiatric and neurological disorders that includes at least one selected from the group consisting of free κ immunoglobulin chains, free λ immunoglobulin chains, and fragments thereof. Using this biomarker for psychiatric and neurological disorders enables the psychiatric and neurological disorders to be easily tested and diagnosed with the blood samples from the subjects. The biomarker enables more effective tests and diagnoses to be conducted combining inflammatory cytokines in the blood of patients with psychiatric and neurological disorders. | 2016-05-12 |
20160131664 | METHOD FOR RISK STRATIFICATION IN STABLE CORONARY ARTERY DISEASE - An in vitro method for the risk stratification of patients with stable arteriosclerosis, especially stable coronary artery disease, is disclosed wherein the concentration of procalcitonin is determined in the circulation of such patients using a highly sensitive PCT assay, and wherein within the range of PCT concentrations in the typical normal range of healthy individuals cutoff values are defined which distinguish groups of individual patients with stable arteriosclerosis in accordance with personal cardiac risk, and patients are allotted to one of said risk groups on the basis of their individual PCT concentrations. | 2016-05-12 |
20160131665 | SRM/MRM Assay for the Insulin Receptor Protein - Specific peptides, and derived ionization characteristics of the peptides, from the Insulin Receptor protein (IR), and its isoforms IR-A and IR-B, that are particularly advantageous for quantifying the IR protein, IR-A isoform and/or IR-B isoform, directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. A protein sample is prepared from said biological sample using the Liquid Tissue™ reagents and protocol and the IR protein, and IR-A and/or IR-B isoforms, is quantitated in the Liquid Tissue™ sample by the method of SRM/MRM mass spectrometry by quantitating in the protein sample at least one or more of the peptides described. These peptides can be quantitated if they reside in a modified or an unmodified form. An example of a modified form of an IR peptide is phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence. | 2016-05-12 |
20160131666 | BIOMARKERS FOR INFLAMMATORY RESPONSE - An in-vitro method for the prediction, prognosis and/or diagnosis of an inflammatory response associated with a condition or disease such as schizophrenia in a subject, the method comprising determining in a sample of a subject the level of 25-hydroxy vitamin D3, preferably in combination with the level of least one biomarker wherein the at least one biomarker is selected from innate chemokine (IL-8) and matrix metalloproteinase (MMP-9); and comparing the levels of said 25-hydroxy vitamin D3 and at least one biomarker to a control level of 25-hydroxy vitamin D3 and the at least one biomarker respectively in order to determine a positive or negative prediction, prognosis and/or diagnosis of said inflammatory response indicating an associated condition or disease, such as schizophrenia. | 2016-05-12 |
20160131667 | LIPID BIOMARKERS FOR STABLE AND UNSTABLE HEART DISEASE - The present invention relates generally to the field of diagnostic and prognostic assays for heart disease. More particular, the present invention provides an assay for diagnosing the presence or extent of development of heart disease or its classification or state thereof. The assay of the present invention is also useful in the stratification of a subject with respect to a risk of developing heart disease. The assay of the present invention is also capable of integration into pathology architecture to provide a diagnostic and reporting system. | 2016-05-12 |
20160131668 | MATERIALS AND METHODS FOR RAPID AND SPECIFIC DETECTION OF COCAINE - The invention pertains to a rapid and specific aptamer-based method for one-step cocaine detection with minimal reagent requirements based on an aptamer sensor that reports the presence of cocaine via the displacement and unquenching of a bound fluorophore molecule. In certain embodiments, the invention provides novel aptamers, which have reduced background fluorescence, bind a fluorophore molecule tightly, and show an increased signal gain in the presence of cocaine. | 2016-05-12 |