16th week of 2009 patent applcation highlights part 47 |
Patent application number | Title | Published |
20090099327 | RAPID EXPANDED SOLVENT EXTRACTION - The present disclosure provides for a method of rapid expanded solvent extraction of biopolymers, such as rubber, from plant materials, such as guayule, using an expanded hexane solvent. As is illustrated herein, the use of the expanded hexane solvent results in a markedly more efficient and rapid extraction process over other supercritical carbon dioxide extraction systems, including those systems using a hexane cosolvent. | 2009-04-16 |
20090099328 | Hydrophobically Modified Polyamine Scale Inhibitors - Hydrophobically modified Si-containing polyamines are useful for treating scale in industrial process streams. Preferred hydrophobically modified Si-containing polyamines are particularly useful for treating aluminosilicate scale in difficult-to-treat industrial process streams, such as in the Bayer alumina process streams, nuclear waste streams and kraft paper mill effluent streams | 2009-04-16 |
20090099329 | Polythiourethane-based polymerizable composition and optical resin obtained from the same - Provided are a polymerizable composition for giving a resin which has a high refractive index and low dispersion, and is especially excellent in impact resistance and tintability; and a resin and an optical component each obtained by curing the composition. There used a polymerizable composition comprising (A) a compound represented by Formula (1) and/or by Formula (2), at least one compound as the following component (B), and at least one compound as the following component (C): | 2009-04-16 |
20090099330 | ADAMANTYL GROUP-CONTAINING EPOXY-MODIFIED (METH)ACRYLATE AND RESIN COMPOSITION CONTAINING THE SAME - The present invention provides an adamantyl group containing epoxy-modified (meth)acrylate and a resin composition containing it which are imparted by transparency, optical characteristics such as (durable) light resistance and the like, heat-resistance, and good mechanical properties. | 2009-04-16 |
20090099331 | SYNTHESIS AND CHARACTERIZATION OF A NOVEL PROTON EXCHANGE MEMBRANE (PEM) FOR APPLICATIONS IN FUEL CELLS - A fuel cell membrane is described comprising at least one sulfonated aromatic polyether copolymer comprising a poly-arylen-ether-ketone (PEK) moiety or sulfonated derivatives thereof, deriving from spiro-bis-indane or 4,4′-(hexafluoroisopropylidene)diphenol (BPAF), and an arylene-sulfone, or an arylene-ketone or sulfonated derivative thereof; said copolymer having the following formula (1): | 2009-04-16 |
20090099332 | FORMALDEHYDE-FREE, OH-FUNCTIONAL, CARBONYL- AND RING-HYDROGENATED KETONE-ALDEHYDE RESINS BASED ON ALKYL ARYL KETONES AND FORMALDEHYDE AND A PROCESS FOR PREPARING THEM - The invention relates to formaldehyde-free, OH-functional, carbonyl- and ring-hydrogenated ketone-aldehyde resins based on alkyl aryl ketones and formaldehyde and having a low fraction of crystallisable compounds, low viscosity, very low colour number, broad solubility, and very high heat stability and light stability, and also to a process for preparing them. | 2009-04-16 |
20090099333 | Compounds Containing Aldimine - The invention relates to compounds of formula (I) which contain aldimine, and to the use thereof. Said compounds which contain aldimines are characterised in that they are odour-less and during hydrolysis the odour-free aldehydes are separated. They are used, therefor, as sources for aldehydes. They can also be used in cross-linking reactions. | 2009-04-16 |
20090099334 | METASTIN DERIVATIVES AND USE THEREOF - The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotrophic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.). By substituting the constituent amino acids of metastin with specific amino acids in the metastin derivative of the present invention, blood stability, solubility, etc. are more improved, gelation tendency is reduced, pharmacokinetics are also improved, and an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity is exhibited. Furthermore, the metastin derivative of the present invention has the effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc. | 2009-04-16 |
20090099335 | Polyomavirus Diagnostic Reagents - The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of human polyomaviruses, which are useful as diagnostic reagents for virus infection. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences. | 2009-04-16 |
20090099336 | CA6 Antigen-Specific Cytotoxic Conjugate and Methods of Using the Same - Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof. | 2009-04-16 |
20090099337 | S-NITROSO GROUP-CONTAINING ALBUMIN, METHOD FOR PRODUCTION, AND ANTICANCER AGENT - The present invention provides an S-nitroso group-containing albumin, comprising an S-nitroso group introduced to at least one lysine in the amino acid sequence for albumin. The S-nitro group has been introduced into a lysine in the S-nitroso group-containing albumin of the invention to allow more S-nitroso groups to be included in the albumin, thus ensuring more potent inhibition of cancer cells in NO groups. | 2009-04-16 |
20090099338 | Novel Protein Highly Producing Recombinant Animal Cell, Method for Preparing the Same, and Method for Mass-Producing Protein Using the Same - A gene encoding a production amount-potentiating factor is introduced into an animal cell to transform the cell. Alternatively, a protein production gene and the gene encoding the production amount-potentiating factor are introduced into the animal cell to transform the cell. Herein, as the production amount potentiating factor, there is used a factor having caspase activity inhibiting activity and/or protein biosynthesis activity potentiating action, for example, baculovirus P35. Further, the animal cell is cultured by a culturing method under a condition that apoptosis is not induced, so that a protein is mass-produced. | 2009-04-16 |
20090099339 | ANTIBODY AND ANTIBODY FRAGMENTS FOR INHIBITING THE GROWTH OF TUMORS - Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors. | 2009-04-16 |
20090099340 | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways - The invention discloses 214 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho-diesterases/Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types. | 2009-04-16 |
20090099341 | Heparanase specific molecular probes and their use in research and medical applications - A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent. | 2009-04-16 |
20090099342 | Process for Preparing Composite Particles, Composite Particles Obtained, and Their Use in a Diagnostic Test - The invention relates to a process for preparing composite particles by encapsulation of an organic-phase-depleted emulsion by polymerization, said emulsion consisting of droplets of inorganic emulsion comprising an organic phase and inorganic nanoparticles distributed in said organic phase, characterized in that the polymerization is carried out using, as the polymerization monomer, from 60% to 100% of at least one crosslinking agent and from 0% to 40% of at least one hydrophobic monomer, it being understood that at least 95% of the crosslinking agent(s) are hydrophobic. The invention further relates to the particles thus obtained, and their use in diagnostics. | 2009-04-16 |
20090099343 | Isolation of pathogenic prions - Peptide reagents that interact preferentially with the PrP | 2009-04-16 |
20090099344 | REDUCING PROTEIN A LEACHING DURING PROTEIN A AFFINITY CHROMATOGRAPHY - A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography. | 2009-04-16 |
20090099345 | Carbon-Based Solid Acid, Catalyst Comprising the Solid Acid, and Reaction Using the Solid Acid as Catalyst - A carbon-based solid acid which has high activity and high thermal stability and is useful as an acid catalyst for various reactions such as hydration of olefins. | 2009-04-16 |
20090099346 | THERMALLY STABLE CRYSTALLINE EPIRUBICIN HYDROCHLORIDE - A crystalline form of epirubicin hydrochloride, named herein as “type II” crystalline epirubicin hydrochloride, has excellent thermal stability. Type II crystalline epirubicin hydrochloride has a powder X-ray diffraction pattern having average values of diffraction angle (2θ) and relative intensity P(%) as presented in the following table: | 2009-04-16 |
20090099347 | CHITOSAN PRODUCTION - The invention provides a method of producing chitosan using pressures greater than 0 PSIG. The invention also provides fungal chitosan compositions. | 2009-04-16 |
20090099348 | NUCLEIC ACID ENCODING A NOVEL RIBONUCLEASE HAVING AN AMINO ACID SEQUENCE MADE UP OF A KNOWN AMINO ACID SEQUENCE AND AN INITIAL N-TERMINAL RESIDUE - A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue. | 2009-04-16 |
20090099349 | Biomarkers For Toxic Algae - The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers. | 2009-04-16 |
20090099350 | Instrument and method for nucleic acid isolation - According to this invention, an instrument and a method for nucleic acid isolation is realized, whereby it is possible to prevent, for example, adherence of a discharged solution upon dispersion of such solution to the vicinity of a nucleic acid isolation column outlet. | 2009-04-16 |
20090099351 | NYLON POLYRIBONUCLEOSIDES - The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I) | 2009-04-16 |
20090099352 | SYNTHESIS OF OLIGONUCLEOTIDES OR PHOSPHOROTHIOATE OLIGONUCLEOTIDE WITH A CAPPING AGENT OF N-METHYLIMIDAZOLE FREE OF 1,3,5-TRIMETHYLHEXAHYDRO-1,3,5-TRIAZINE - According to the present invention, there is provided a process for making an oligonucleotide or a phosphorothioate oligonucleotide. The process has the following steps: (a) providing an amount of a blocked nucleotide; (b) deblocking the blocked nucleotide to form an unblocked nucleotide; (c) activating the deblocked nucleotide; (d) coupling the deblocked nucleotide with a phosphoramidite to form a phosphite oligomer; (e) capping any uncoupled deblocked nucleotide via reaction with an amount of acetic anhydride and an amount of N-methylimidazole that is substantially free of 1,3,5-trimethylhexahydro-1,3,5-triazine; (f) oxidizing the phosphite oligomer to form the oligonucleotide or sulfurizing the phosphite oligomer to form a phosphorothioate oligonucleotide; and (g) optionally repeating steps (b) through (f). There is also a process for capping a nucleotide. | 2009-04-16 |
20090099353 | COMPOSITE FIBRE OF ALGINATE AND CHITOSAN - There are provided composite fibres of alginate and chitosan. Also provided are fibre materials methods of producing composite fibres or films and composite films. In one embodiment there is provided a composite fibre of alginate and chitosan suitable for use in wound management products, wherein chitosan polymer is bonded to alginate polymer along the length of the fibre. | 2009-04-16 |
20090099354 | METHOD FOR SEPARATING POLYMERIC PENTOSE FROM A LIQUID/SLURRY - The present invention provides a method for extracting polymeric pentose, preferably xylan, from a polymeric pentose containing liquid/slurry, preferably black liquor, comprising the following steps: a) providing a polymeric pentose containing liquid/slurry; b) concentrating the polymeric pentose by membrane separation of a said polymeric pentose containing liquid/slurry; and c) adding alcohol to the concentrate obtained in step b) and subsequently acidifying said concentrate obtained in step b) for precipitating polymeric pentose whereby a polymeric pentose product, or an intermediate polymeric pentose product, is obtained. In this above way polymeric pentose, e.g. xylan, is separated whereby the use of methanol (less lignin must be kept in solution) and acid (less acid which buffers the pH-decrease) become much lower. The present invention also provides according to a second aspect a polymeric pentose product or an intermediate polymeric pentose product obtainable by the method according to the first aspect. The present invention also provides according to a third aspect use, preferably for the production of food additives or as chemical feed stock, of the polymeric pentose product or the intermediate polymeric pentose product of the second aspect of the invention. | 2009-04-16 |
20090099355 | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids - The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula | 2009-04-16 |
20090099356 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION - The present invention is directed to a process for preparing compounds of formula (I): wherein A, R | 2009-04-16 |
20090099357 | AGENT FOR THE PREVENTION AND TREATMENT OF PROSTATIC HYPERPLASIA COMPRISING PYRAZOLOPYRIMIDINONE COMPOUND - The present invention relates to an agent for preventing and treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with BPH and a relaxant for relaxing urethral smooth muscle or prostatic smooth muscle comprising a pyrazolopyrimidinone compound as an effective ingredient. The agent in accordance with the present invention can provide nitric oxides by inhibiting the activity of PDE-5 that decomposes c-GMP, and the provided nitric oxides relax the urethral smooth muscle or the prostatic smooth muscle to lower the intraurethral pressure (IUP), thus treating BPH and LUTS associated with BPH. Furthermore, the time required for reaching a maximum blood concentration is shorter and the half-life is longer than the other PDE-5 inhibitors, thus reducing the frequency of administration. Moreover, the agent of the invention causing few side effects can be efficiently used as a safe drug. | 2009-04-16 |
20090099358 | BISPHOSPHOLANES FOR USE AS CATALYSTS IN ASYMMETRIC REACTIONS - The invention is a set of novel bisphospholane ligands that can be complexed with transition metals. These complexes are useful as catalysts in asymmetric reactions such as asymmetric hydrogenation. | 2009-04-16 |
20090099359 | ESZOPICLONE PROCESS - Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-pyrazine with 1-chlorocarbonyl-4-methylpiperazine hydrochloride. | 2009-04-16 |
20090099360 | Method for Cleaning 3-Hydroxyamidinophenylalanine Derivatives by the Precepitation and Recrystallization of Salt and an Aromatic Sulfonic Acid - The present invention relates to the preparation of 3-hydroxyamidino-phenylalanine derivatives in highly pure form which can be used for example as urokinase inhibitors. The present invention further relates to the use of high-purity 3-hydroxyamidinophenylalanine derivatives for preparing 3-amidinophenylalanine derivatives. | 2009-04-16 |
20090099361 | NOVEL TANTALUM AND NIOBIUM COMPOUNDS - The present invention relates to specific, novel tantalum and niobium compounds which can serve as starting materials for the preparation of chemical vapour deposition (CVD) precursors. | 2009-04-16 |
20090099362 | Process for the preparation of gabapentin hydrochloride - A process for preparation of gabapentin hydrochloride by converting 1,5-dicyano-2,4-dioxo-3-azaspiro[5,5]-undecane into 1,5-diaminoformyl-2,4-dioxo-3-azaspiro[5,5]-undecane at a temperature of 65° C. to 85° C. in the presence of a strong acid, and then carrying out Hofmann rearrangement under an alkaline condition. The starting material of the process is readily available. The process is simple, and can reduce the purification procedure of intermediates, reduce production cost, and obtain product with higher purity. | 2009-04-16 |
20090099363 | PROCESS FOR THE PREPARATION OF POLYMORPHIC FORMS OF CLOPIDOGREL HYDROGEN SULFATE - The present invention relates to a novel process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate, namely methyl(+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate hydrogen sulfate of formula (I). Particularly the present invention relates to the process for the preparation of form (I) and amorphous clopidogrel hydrogen sulfate. | 2009-04-16 |
20090099364 | Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5- tert-butyl-2-methoxybenzyl)quinuclidin-3-amine - This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter “compound of Formula I”) and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (Ia). | 2009-04-16 |
20090099365 | Processes for solifenacin preparation - Processes for preparing solifenacin comprising distilling ethanol and organic solvent from a reaction mixture and recycling the organic solvent are described. Also described are processes for reducing solifenacin diastereomeric and enantiomeric impurities. | 2009-04-16 |
20090099366 | PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS - The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties. | 2009-04-16 |
20090099367 | Process for preparing a leukotriene antagonist - Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation. | 2009-04-16 |
20090099368 | DEHYDROGENATION PROCESS - Processes comprising: providing a dehydrogenatable compound; and subjecting the dehydrogenatable compound to a dehydrogenation reaction at a temperature of from 150 to 400° C., in the presence of oxygen, and at a temperature profile of the dehydrogenation reaction which does not differ substantially from the temperature profile of the dehydrogenation reaction in the absence of oxygen under otherwise identical conditions. | 2009-04-16 |
20090099369 | PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-OXO-2-SUBSTITUTED-2,3-DI- HYDRO-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS - A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula | 2009-04-16 |
20090099370 | Crystalline Form of Perindopril Erbumine - The present invention relates to new crystalline form of the ACE inhibitor perindopril and processes for the preparation thereof. | 2009-04-16 |
20090099371 | PROCESS FOR THE PREPARATION OF AMORPHOUS ATORVASTATIN CALCIUM SALT - Disclosed is a novel process for preparing pure amorphous form of Atorvastatin employing a suitable solvent system selected from water, water-miscible solvents or water-immiscible solvents or a mixture thereof. | 2009-04-16 |
20090099372 | Colorant Compounds - A compound of the formula | 2009-04-16 |
20090099373 | COMPOSITIONS ENRICHED IN ANTHOCYANINS - This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin. | 2009-04-16 |
20090099374 | METHOD FOR PRODUCING FLAVAN DERIVATIVE - The present invention provides a method for producing flavan derivatives having various substituent groups with controlling the stereochemistry. The method of the present invention includes the steps of: hydratively condensing a phenol compound expressed by formula (I) and an alcohol compound expressed by formula (II) to from an epoxide compound of formula (III); opening the epoxy ring of the epoxide compound of formula (III) to form an iodine-containing compound of formula (IV); and cyclizing the iodine-containing compound to form the flavan derivative of formula (V). | 2009-04-16 |
20090099375 | process for the preparation of escitalopram - The present invention relates to an improved process for the preparation of Escitalopram of the Formula (I), which comprises, isolation of Diol compound as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula (VII). The present invention provides a process to obtain pure Diol compound by preparing its Oxalate salt, which is useful for resolution of enantiomers. | 2009-04-16 |
20090099376 | TIGECYCLINE AND METHODS OF PREPARING INTERMEDIATES - Methods of preparing and purifying 9-nitrominocycline and 9-aminominocycline and salts thereof used in the process of making tigecycline, are disclosed. In one embodiment, the invention is directed to a method of preparing the compound of formula 1 | 2009-04-16 |
20090099377 | PRODUCTION OF INCREASED OIL AND PROTEIN IN PLANTS BY THE DISRUPTION OF THE PHENYLPROPANOID PATHWAY - The present invention provides methods and compositions relating to generating plants having increased levels of oil and protein. This invention further provides recombinant expression cassettes, host cells, transgenic plants and genetically altered plants. The invention further provides isolated polynucleotides and their encoded proteins that are involved in phenylpropanoid biosynthesis. | 2009-04-16 |
20090099378 | GENERATION OF PLANTS WITH ALTERED OIL CONTENT - The present invention is directed to plants that display an altered oil content phenotype due to altered expression of ICL nucleic acid. The invention is further directed to methods of generating plants with an altered oil content phenotype. | 2009-04-16 |
20090099379 | Extraction and Winterization of Lipids from Oilseed and Microbial Sources - A process for purifying a lipid composition having predominantly neutral lipid components having at least one long chain polyunsaturated fatty acid is disclosed. The process employs contacting the lipid composition with a polar solvent, such as acetone, wherein the solvent is selected such that contaminants are less soluble in the solvent than is the long chain polyunsaturated fatty acid. The process is typically conducted at cooler temperatures, including about 0° C. Upon precipitation of the contaminants from the lipid composition, a separation is conducted to remove the precipitated material from the lipid composition. The long chain polyunsaturated fatty acids can include ARA, DPA, EPA, and/or DHA. The process of the present invention effectively winterizes lipid compositions, thereby reducing the tendency of such compositions to become hazy. | 2009-04-16 |
20090099380 | Fatty acid alkyl ester production from oleaginous seeds - A process is described for producing fatty acid alkyl esters for both diesel fuel and non-fuel uses. The feed material includes whole oleaginous seeds slurried in a liquid triglyceride oil containing at least two weight percent free fatty acid, wherein oil from inside the seeds is first extracted with concurrent esterification of free fatty acids from all sources in an acidic environment. Following sufficient free fatty acid reaction, the intermediate product is subjected to base-catalyzed concurrent extraction and transesterification. Decanting of the byproduct glycerin is followed by water washing. Subsequently, the fatty acid ester product is concurrently purified and fractionated into a biodiesel fuel stream and a non-fuel fraction, each of which undergoes post treatment as needed. The process is optionally integrated with glycerin purification and/or methanol recovery. | 2009-04-16 |
20090099381 | Optically Active Alpha-Hydroxyphosphonic Acid, Its Derivatives and Production Method thereof, Optically Active Aluminum (Salalen) Complex and Production Method Thereof, and Production Method of Salalen Ligand - The present invention relates to a production method capable of producing an optically active α-hydroxyphosphonic acid and its derivatives with sufficiently high enantioselectivity not only for aromatic aldehydes but also for aliphatic aldehydes, and more specifically to a method of producing an optically active α-hydroxyphosphonic acid and its derivatives, characterized in that an optically active aluminum(salalen) complex represented by any one of the following formulae (I), (I′), (II) and (II′): | 2009-04-16 |
20090099382 | ACTIVE INGREDIENT CARRIERS WHICH ARE BASED ON SILICON AND CONTAIN AMINOALKYL GROUPS - Silicon compounds comprising at least one silicon atom, at least one alkoxy group of the formula —OR′ bonded to silicon, and at least one aminoalkyl group bonded to silicon, wherein the alkoxy group is derived from an active substance alcohol of the formula R′OH, and the use thereof for perfuming or preserving laundry detergents and cleaners or cosmetic compositions. | 2009-04-16 |
20090099383 | Purification of rosuvatatin intermediate by thin film evaporation and chemical method - Provided are processes for the purification of a pure rosuvastatin intermediate by thin film evaporation and chemical method, and conversion of the intermediate to rosuvastatin or salts thereof. | 2009-04-16 |
20090099384 | Method of Remedying Deterioration of Insulating Film - The present invention provides a method of remedying deterioration of an insulating film which, during the remedial treatment of an insulating film deteriorated by plasma treatment, does not leave residual remedial agent on the wiring material such as the copper wiring layer, can be conducted using a dry process, and exhibits excellent applicability to mass production. The insulating film that has been deteriorated by plasma treatment is brought into contact with a remedial agent composed of a compound with a molecular structure having at least one of a nitro group and a carbonyl group, and at least one of a hydrocarbon group and a hydrogen group. | 2009-04-16 |
20090099385 | PROCESS FOR MAKING ALKALINE EARTH METAL BORATED SULFONATES - An alkaline earth metal borated sulfonate prepared by a process comprising reacting a mixture of the following materials(A) (1) at least one of an oil soluble sulfonic acid or alkaline earth sulfonate salt or mixtures thereof (2) at least one source of an alkaline earth metal; and (3) at least one source of boron, in the presence of a mixture of comprising (4) at least one hydrocarbon solvent; and (5) at least one low molecular weight alcohol; and (6) from 0 to less than 10 mole percent, relative to the source of boron, of an overbasing acid, other than the source of boron; and (B) heating the reaction product of (A) to a temperature above the distillation temperatures of (4) and (5) to distill (4), (5) and water of reaction, wherein no additional water is added in the process. | 2009-04-16 |
20090099386 | Method for the production of dinitrile compounds - The present invention relates to a process for the manufacture of dinitrile compounds by double hydrocyanation of an olefin. | 2009-04-16 |
20090099387 | POTASSIUM FLUORIDE DISPERSION SOLUTION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME - A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion. | 2009-04-16 |
20090099388 | RECOVERY OF AROMATIC DICARBOXYLIC ACIDS FROM WASTE POLYESTER RESIN IN THE PRESENCE OF A POLYAMIDE - The present invention relates to a process of recovering aromatic dicarboxylic acids with low metal contaminants from manufactured articles, such as beverage bottles, fibers and films, comprising aromatic polyesters, whether or not those articles are contaminated with PVC or chlorinated compounds, or from waste from processing of these polyesters. In particular, the invention relates to the recovery of terephthalic acid, isophthalic acid and 2,6-naphthalene dicarboxylic acid from bottles for recycling which are made of PET, PEN or aromatic polyester copolymers. | 2009-04-16 |
20090099389 | Method and apparatus for making acetic acid with improved productivity - An improved apparatus and method of producing acetic acid includes recovering product from the residue of a light ends column and feeding the acid so recovered forward in order to increase system productivity. Load on the light ends column is reduced and load on a dehydrating column may also be lessened in a preferred embodiment where the recovered acid is fed forward without further water removal. | 2009-04-16 |
20090099390 | Crystalline forms of ibandronic acid and processes for the preparation thereof - A crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about 4.1, 12.3 and 13.4±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 8.2, 11.3, 16.2 and 16.9 and 20.8±0.2 degrees two-theta, and by a powder X-ray diffraction pattern depicted in FIG. | 2009-04-16 |
20090099391 | Novel Aryl Compound - A novel aryl compound represented by the formula (1) in which the characteristic groups represented by X | 2009-04-16 |
20090099392 | METHOD FOR PRODUCING 3-METHYL-1,5-PENTANEDIOL - Provided is a method for producing 3-methyl-1,5-pentanediol by hydrogenating 2-hydroxy-4-methyltetrahydropyran in the presence of a hydrogenation catalyst, characterized in that the hydrogenation is further carried out in the presence of a basic compound. By this method, in producing MPD by hydrogenation of MHP, high-purity MPD can be produced by effectively suppressing generation of by-products such as MPAE and MVL even when a known hydrogenation catalyst is used. | 2009-04-16 |
20090099393 | SOLID CATALYST USEFUL FOR CONVERTING AN ALKYLENE OXIDE TO AN ALKYLENE GLYCOL - A solid (i.e., heterogeneous) catalyst useful for preparing an alkylene glycol from the corresponding alkylene oxide as well as a process for the catalytic hydration of an alkylene oxide to an alkylene glycol utilizing such a catalyst are provided. The catalyst of the present invention is based on an ion exchange resin including polystyrene crosslinked with from about 2 to about 10 weight (wt.) % divinyl benzene. The ion exchange resin further includes quaternary ammonium groups or quaternary phosphonium groups. The process includes reacting water and an alkylene oxide in at least one reactor under conditions to form an alkylene glycol, wherein the at least one reactor includes a catalyst based on an ion exchange resin that includes polystyrene crosslinked with from about 2 to about 10 weight (wt.) % divinyl benzene. | 2009-04-16 |
20090099394 | PROCESS FOR OBTAINING A PURIFIED HYDROFLUOROALKANE - Process for obtaining a hydrofluoroalkane which is purified of organic impurities, according to which the hydrofluoroalkane containing organic impurities is subjected to at least one purification treatment chosen from
| 2009-04-16 |
20090099395 | Method for Producing 1,3,3,3-Tetrafluoropropene - There is provided a method for producing 1,3,3,3-tetrafluoropropene. This method includes dehydrofluorinating 1,1,1,3,3-pentafluoropropane in gas phase in the presence of a zirconium compound-carried catalyst in which a zirconium compound is carried on a metal oxide or activated carbon. | 2009-04-16 |
20090099396 | PROCESS FOR SYNTHESIS OF FLUORINATED OLEFINS - Disclosed is a process for the synthesis of fluorinated olefins, and in particularly preferred embodiments tetrafluorinated olefins having F on an unsaturated, non-terminal carbon, such as 2,3,3,3-tetrafluoropropene. The preferred processes of the present invention in accordance with one embodiment generally comprise:
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20090099397 | BLENDING PROCESSES AND SYSTEMS - Processes and systems are provided for monitoring and blending a first stream and a second stream to produce a third stream of desired compositional characteristics. The processes and systems are found to be particularly useful for the blending of two or more hydrocarbon streams to economically produce a targeted hydrocarbon product stream meeting prescribed compositional specifications. Specifically, the processes and systems are found to be especially useful to blend a propane containing stream, having a vapor pressure lower than the vapor pressure of a targeted vapor pressure for a propane product, with an ethane containing stream. The blending processes and systems allow for production of an “on-spec” propane product stream while at the same time maximizing the value of the ethane stream. The processes and systems may incorporate continuous real-time analysis and flow control of the various streams to effectuate precise control the blending processes. | 2009-04-16 |
20090099398 | Pentane Catalytic Cracking Process - A process is presented for the production of light olefins from a paraffin stream comprising pentanes. | 2009-04-16 |
20090099399 | Layered Zeolitic Catalyst for Improved Linearity in Detergent Alkylation - A process is disclosed wherein a layered catalyst is used for the alkylation of benzene with a substantially linear olefin. The layered catalyst allows for shifting the operating conditions to increase the alkylation of benzene, while reducing the amount of isomerization of the alkyl group. This is important for increasing the quality of the alkylbenzene by increasing the linearity of the alkylbenzene. | 2009-04-16 |
20090099400 | Solid phosphoric acid catalyst and methods of olefin dimerization reaction with the same - A solid phosphoric acid catalyst which has high activity and attains high dimer selectivity in olefin dimerization reactions; and efficient methods of olefin dimerization reaction. The solid phosphoric acid catalyst comprises a carrier and phosphoric acid supported thereon. When the solid phosphoric acid catalyst is heated at 250° C. for 20 minutes, heating loss of water is 50 mass % or more based on diphosphorus pentaoxide (P | 2009-04-16 |
20090099401 | Process for making isooctenes from aqueous isobutanol - The present invention relates to a catalytic process for making isooctenes using a reactant comprising isobutanol and water. The isooctenes so produced are useful for the production of fuel additives. | 2009-04-16 |
20090099402 | IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION - In an embodiment a therapeutic member includes a solitary radioactive seed. The seed includes a metallic housing with radioactive material contained within the metallic housing. The metallic housing has a first longitudinal end and a second longitudinal end and a longitudinal length between the first and second longitudinal ends. A polymeric material is molded to completely and monolithically encapsulate the metallic housing of the solitary radioactive seed. The implantable therapeutic member is adapted to be implanted into patient tissue using a hollow needle. A portion of the molded polymeric material extends from one of the first and second longitudinal ends of the metallic housing to reduce a tendency of the seed to migrate and rotate within a patient's body after implantation of the member. The portion of the molded polymeric material, that extends from one of the first and second longitudinal ends of the metallic housing, causes the implantable therapeutic member to have a longitudinal length that is greater than the longitudinal length of the metallic housing. | 2009-04-16 |
20090099403 | Implant Magnet Insertion and Removal Tools - A magnet positioning tool is described for use with an implantable device. The device has a pair of opposing positioning surfaces, at least one of which has a magnet cradle for mechanically engaging an implant magnet associated with a magnet position in the implantable device. The tool also includes a position engagement surface for engaging the implantable device when the magnet cradle is adjacent to the magnet position. | 2009-04-16 |
20090099404 | IMPLANTABLE DEVICE, SYSTEM FOR GENERATING LOCALISED ELECTROMAGNETIC FIELDS IN THE AREA OF AN IMPLANT AND COIL ARRANGEMENT - The invention relates to an implantable device to be fixed to a bone and comprising an electrically conductive base body provided with at least two through holes and at least one pair of shaft-shaped contact means, wherein each contact means passes through a through hole of the base body and penetrates a section of the bone in an implanted state, wherein the surface of each contact means comprises a first and a second electrically conductive surface section as well as an electrically insulating surface section separating the electrically conductive surface sections from each other, wherein the first electrically conductive surface section electrically contacts the base body while the second electrically conductive surface section is electrically insulated with respect to the base body, wherein each contact means contains a coil arrangement in its interior by means of which the electrically conductive surface sections of each contact means are electrically coupled, and wherein the coil arrangements of a pair are wound in opposite directions. | 2009-04-16 |
20090099405 | MONOPHASIC MULTI-COIL ARRAYS FOR TRANCRANIAL MAGNETIC STIMULATION - Efficient use of multi-coil arrays for magnetic nerve stimulation depends upon coordinating the coil polarity, the pulse phase and the pulse timing. Monophasic magnetic nerve stimulators produce more precise and predictable results in the stimulation of nerves than biphasic and polyphasic machines, but are less electrically efficient, and consequently limited in terms of pulse train speed. The present invention concerns the coordination of pulse polarity, phase, timing, and strength between multiple magnetic stimulation coils. The goal is to optimize the manner in which multiple coils may be used synergistically to control the activity of underlying neural tissue. | 2009-04-16 |
20090099406 | Control system for a blood pump - A method of controlling the speed of a blood pump, wherein the method includes the steps of deriving an estimated pulsatility index from speed, then deriving an estimated blood pressure from estimated pulsatility index; and maintaining target blood flow rate near to or at a preset value by adjusting the speed. | 2009-04-16 |
20090099407 | SALT ROOM AND A METHOD FOR COATING THE WALL/CEILING OF A SALT ROOM - The interior surface of one or more walls/ceiling of the salt room is composed of inner, intermediate and outer layers. In the salt room, the salt is attached to the interior surfaces as an outer layer with an underlying intermediate layer containing salt and adhesive agent and acting as a binding agent. A binding agent is spread onto the interior surfaces of the walls of the salt room on top of the moisture insulator. Into the binding agent are embedded salt granules, after which to the binding agent surfaces containing salt granules an adhesive layer is added, which penetrates into the binding agent and attaches to the salt granules. Salt is spread on the adhesive layer as a porous coating, wherein the adhesive agent holds on to the salt layer in the binding agent surface. | 2009-04-16 |
20090099408 | METHODS AND APPARATUS FOR TREATING TINNITUS - Methods and apparatus for treating tinnitus are described where an oral appliance having an electronic and/or transducer assembly for generating sounds via a vibrating transducer element is coupled to a tooth or teeth. Generally, the transducer may generate one or more frequencies of sound via the actuatable transducer positioned against at least one tooth such that the sound is transmitted via vibratory conductance to an inner ear of the patient, whereby the sound completely or at least partially masks or provides sound therapy for habituation of the tinnitus perceived by the patient. The one or more generated frequencies may be correlated to measured tinnitus frequencies or they may be preset. | 2009-04-16 |
20090099409 | MEDICAL SHEET - A medical sheet has an intricate pattern of loops, struts and bridges and is made of a super elastic alloy. The medical sheet includes a plurality of amorphic circles which provide rounded surfaces attached to the outer edges which made the medical sheet a-traumatic when implanted. When the medical sheet is cooled the molecular phase becomes martensitic which allows the medical sheet to be compressed for easier insertion into a patient. When the medical sheet is heated, the molecular phase changes to austenitic which causes the medical sheet to expand to a size suitable for implantation. The medical sheet can be secured within the patient by suturing through holes in the amorphic circles. | 2009-04-16 |
20090099410 | Papillary Muscle Attachment for Left Ventricular Reduction - The surgical implantation of a link, which may be in the form of a tether or a looped band, is proposed to connect and reduce the spacing between papillary muscles, to reduce dilation of the left ventricle. The implanted link thus improves heart function by reducing left ventricular failure. | 2009-04-16 |
20090099411 | DEVICE TO PERMIT OFFPUMP BEATING HEART CORONARY BYPASS SURGERY - A suction cup adapted to engage a surface of a beating heart with sufficient force to move the beating heart to an unnatural position upon moving the suction cup, while the suction cup maintains engagement with the surface of the heart and the heart continues to beat. Various suction cups are described each including at least a first chamber having a flexible rim and configured to engage the surface of the beating heart and a second chamber smaller than the first chamber and fluidly connected therewith. A suspension device configured to engage a beating heart and maintain engagement via suction while moving the suspension device to move the beating heart to an unnatural position and maintain the beating heart in the unnatural position to perform a surgical procedure, while the heart continues to beat, includes a suction cup and a support arm connected thereto. The suction cup has a first chamber configured to engage the surface of the beating heart and a second chamber smaller than the first chamber and fluidly connected therewith. The second chamber is adapted to fluidly connect the first chamber with a source of suction. The support arm is movable with the suction cup to effect movement of the beating heart after engagement of the suction cup to a surface of the beating heart. A method of manipulating a beating heart to orient the beating heart in a desired position for performing a surgical procedure includes providing a suction cup having a first chamber configured to engage the surface of the beating heart, and a second chamber smaller than the first chamber and fluidly connected with the first chamber, the second chamber being further fluidly connected to a source of suction; contacting a surface of the beating heart with the first chamber; applying suction between the first chamber and the surface of the beating heart, thereby engaging the suction member with the surface of the beating heart; and moving the suction member while maintaining engagement with the surface of the beating heart, thereby moving the beating heart. | 2009-04-16 |
20090099412 | Device to Permit Offpump Beating Heart Coronary Bypass Surgery - A system for manipulating a heart during cardiac surgery permits coronary surgery on a beating heart while maintaining cardiac output unabated and uninterrupted. Circumflex coronary artery surgery can be performed using the system. A component of the system engages the heart with a heart positioning device, repositions the heart into a displaced position and maintains it in the displaced position while the heart continues to beat with substantially unabated and uninterrupted cardiac output. One form of the system can be used in minimally invasive surgery. | 2009-04-16 |
20090099414 | METHOD OF PERFORMING DIAGNOSIS OR TREATMENT ERENDOSCOPICALLY AND MEDICAL TREATMENT DEVICE - A method of performing diagnosis or treatment perendoscopically in which a guide catheter is inserted inside a body, and the guide catheter is made to protrude beyond a distal end portion of the endoscope; and in which a first diagnosis or treatment is performed by inserting a medical treatment device that performs the diagnosis or treatment of the body inside the guide catheter, and causing this medical treatment device to protrude by a first predetermined distance from the guide catheter; and in which the medical treatment device is extracted from the guide catheter; and in which a second diagnosis or treatment is performed by inserting a medical treatment device into the guide catheter, and causing the medical treatment device to protrude by a second distance which is adjusted in accordance with the first predetermined distance. | 2009-04-16 |
20090099415 | Endoscopic Instrument System for Implanting a Device in the Stomach - An endoscopic delivery system is provided to deliver a functional device through the esophagus and into the stomach where it is attached the stomach wall. The endoscopic instruments attach or remove the attachment devices and functional devices from the stomach and may be used to assist in determining the optimal attachment location. | 2009-04-16 |
20090099416 | CAPSULE ENDOSCOPE - A capsule endoscope is disclosed that includes a capsule and a transparent cover having a central axis and that is located in front of an objective optical system within the capsule. The objective optical system has a depth of field, a field of view, and an image surface that has curvature of field, and is arranged on the central axis of the transparent cover and the capsule. The field of view of the objective optical system includes a spherical surface that is tangent to the transparent cover at a periphery of the field of view, and the near point of the depth of field on the optical axis of the objective optical system is positioned farther from the objective optical system than is the transparent cover. Various conditions are satisfied so as to provide high quality imaging. | 2009-04-16 |
20090099417 | DISPOSABLE ENDOSCOPE - This invention relates to an endoscope, particularly a bronchoscope, incorporating one or more multifunctional component made of a material that is multifunctional. The endoscopes of this invention comprise at least one multifunctional component having more than one function wherein the functions were previously performed separately by individual components. | 2009-04-16 |
20090099418 | IN-VIVO INFORMATION ACQUIRING APPARATUS AND POWER SUPPLY CONTROL METHOD - An in-vivo information acquiring apparatus includes an information acquiring unit that acquires in-vivo information; a power source that supplies a power to the information acquiring unit; a magnetic sensor unit that outputs a control signal corresponding to a state in which a magnetic signal externally input is detected; a pulse number counting unit that counts the number of pulses of pulse signals from the magnetic sensor unit. When the number of pulses counted by the pulse counting unit is not smaller than a predetermined number, a state in which the power from the power source is supplied to the information acquiring unit is switched to a state in which the power from the power source to the information acquiring unit is cut off. | 2009-04-16 |
20090099419 | SWITCHING MECHANISM FOR SWALLOWABLE MEDICAL DEVICE - A switching mechanism for a swallowable medical device has first and second contacts and an expandable member. The medical device has a shell and a first circuit unit provided in the shell. The first and second contacts are electrically connectable with each other, and an operation of the first circuit unit is switched by electrically connecting the first and second contact. The expandable member is capable of expanding by absorbing a predetermined liquid. The expandable member displaces the second contact by expanding such that the second contact gets electrically connected to or disconnected from the first contact. | 2009-04-16 |
20090099420 | SYSTEM FOR MANAGING BOWDEN CABLES IN ARTICULATING INSTRUMENTS - The present invention relates, generally, to the reduction or elimination of permanent and catastrophic herniations in Bowden cables or coil pipes in articulating devices or snake-like robots. More particularly, the present invention relates managing the coil pipes in a spiral pattern along the articulating device or snake-like robot to reduce or eliminate the necessity of the Bowden cables or coil pipes to slide along the length of the articulating device or snake-like robot. Reduction or elimination of the necessity for the Bowden cables or coil pipes to slide reduces or eliminates catastrophic herniations in articulating devices or snake-like robots undergoing one or more articulations. | 2009-04-16 |
20090099421 | Intubation laryngoscope with a double holder - Intubation laryngoscope having reusable and disposable blades, an illumination system, and an advantageous fastening appliance for connecting the blades to the laryngoscope handle. | 2009-04-16 |
20090099422 | Specula - A supplementary blade for a speculum, the speculum having a plurality of primary blades movable relative to each other for opening and closing, wherein the supplementary blade comprises an anchor portion attachable to the speculum and a blade portion movable with respect to the anchor portion, and the blade portion is shaped to interact with at least one of the primary blades to move into an extended position in response to opening of the primary blades. | 2009-04-16 |
20090099423 | CONNECTOR ASSEMBLY - A connector assembly according to embodiments of the present disclosure is advantageously configured to allow a sensor connector to straightforwardly and efficiently join with and detach from a patient cable connector. Further, embodiments of the connector assembly advantageously reduce un-shielded area in an electrical connection between a patient cable and a sensor connector. In addition, embodiments of the connector assembly advantageously increase the shielding of detector signals coming from the patient sensor to the monitor. | 2009-04-16 |
20090099424 | Patient Monitoring - A hemodynamic monitor and corresponding method for determining the requirement for, and if required the nature or extent of, and for monitoring the response to, an intervention by a carer for a subject in order to improve the hydration level and hemodynamic status of the subject during a period or periods of hemodynamic instability includes, firstly, a processor. The processor incorporates software arranged to continuously analyse and process a blood pressure or arterial volume/plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates display means displaying images representing the derived plurality of complementary parameters. The images include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time to provide an immediate indication of a change in hemodynamic status and thus the requirement for an intervention. The images also include at least one image representing graphically at least one fluid responsiveness parameter plotted against time to provide an indication of the hydration level and associated ventricular pre load status of the subject to determine the nature or extent of the intervention if required. The images may also include at least one image representing graphically at least one response related parameter compared to the value of the parameter at the point of the intervention to provide an indication of the desired and/or actual response of the subject to an intervention. Trend and acute changes displays may be combined. Specific parameters providing information on the quality of the left ventricle and right heart/venous return/preload may also be derived and displayed. | 2009-04-16 |
20090099425 | INTEGRATED TAIL MOUNTED BLOOD PRESSURE MONITOR AND PULSE OXIMETER SYSTEM FOR ANIMAL RESEARCH - An integrated tail mounted blood pressure monitor and pulse oximeter system includes a tail blood flow occlusion member configured to selectively occlude blood flow through the tail; a sensor coupled to the tail blood flow occlusion member detecting a degree of operation thereof; Light sources coupled to the tail closer to the distal end of the tail than the tail blood flow occlusion member, and selectively directing light of two different wavelengths into the tail; a light receiver coupled to the tail and selectively receiving a signal associated with light directed into the tail from the light sources; and a controller configured to selectively determine blood pressure parameters from the data and pulse oximeter parameters from the data. | 2009-04-16 |
20090099426 | DIFFERENTIATING DECOMPENSATION DETECTION BASED ON CO-MORBIDITIES IN HEART FAILURE - This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process. | 2009-04-16 |
20090099427 | MICRONEEDLE ARRAY WITH DIVERSE NEEDLE CONFIGURATIONS - The invention relates to a surface penetration device, a method to use the device, and an analyte monitor. Embodiments of the surface penetration device include a substrate with first and second surfaces, and first and second tissue piercing elements, the elements differing in configuration, but each associated with the first surface of the substrate. At least some of the tissue piercing elements have a distal and a proximal opening and a lumen extending between the openings. The proximal openings are in fluid communication with an opening in the second surface of the substrate. Embodiments of the analyte monitor include the features of the penetration device plus an analyte sensor that detects an analyte in a fluid. Embodiments of the method of penetrating tissue include providing a surface penetration device and urging the surface penetration device against a tissue surface until some of the first and second tissue piercing elements penetrate the tissue surface. | 2009-04-16 |