04th week of 2014 patent applcation highlights part 40 |
Patent application number | Title | Published |
20140024050 | ANTIBODIES WHICH DETECT PIVKAII AND METHODS OF USE THEREOF - The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions. | 2014-01-23 |
20140024051 | Methods and Compositions for Biomarkers of Fatigue - The present invention provides methods and compositions for identifying fatigue, disease states associated with fatigue, recovery from fatigue and/or physical performance capability in a subject. | 2014-01-23 |
20140024052 | SEQUENCE-SPECIFIC EXTRACTION AND ANALYSIS OF DNA-BOUND PROTEINS - An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for down-stream analysis by quantitative mass spectrometry or ELISA. The identification of DNA-bound proteins, histones and their post-translational modification is of high scientific and pharmaceutical importance due to the role of DNA-binding proteins in the causation and development of human disease; in particular, cancer. | 2014-01-23 |
20140024053 | METHODS, KITS AND DEVICES FOR DETECTING BII-SPECTRIN, AND BREAKDOWN PRODUCTS THEREOF, AS BIOMARKERS FOR THE DIAGNOSIS OF NEURAL INJURY - The present invention identifies biomarkers that are diagnostic of neural injury, neuronal disorder or neurotoxicity and is related to the discovery that proteases are selectively activated in subjects suffering from nervous system damage as compared to healthy subjects. Breakdown products reflecting protease activation are produced and detection of these different biomarkers of the invention is also diagnostic of the degree of severity and type of nerve damage in a subject. | 2014-01-23 |
20140024054 | ANTIBODY, KIT AND METHOD FOR DETERMINING AMYLOID PEPTIDES - The invention relates to the field of immunoassays which allow the detection of Aβ 17 peptides by virtue of the use of an anti-Aβ 17 antibody and a kit and method using said antibody. The invention also relates to a method for diagnosing or distinguishing between different stages of a neurodegenerative disease. | 2014-01-23 |
20140024055 | ANTIHUMAN BAFF ANTIBODY - An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO. 1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody. | 2014-01-23 |
20140024056 | SURROGATES OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND USES THEREOF - The present invention provides compounds that are surrogates of post-translationally modified proteins and uses thereof. Numerous diseases are associated with post-translationally modified proteins that are difficult to obtain in homogenous form and in quantities needed for immunization and use as convenient standards, calibrators, and/or reference compounds that facilitate the detection and analysis of endogenous post-translationally modified proteins. The surrogate compounds of the invention typically comprise antigenic epitopes (one of which carries a post-translational modification) that are tethered by a flexible and hydrophilic linker. The resulting compound behaves like a surrogate of the post-translationally modified protein because it preserves the character of the included antigens and allows recognition by specific antibodies targeting the individual antigens. The surrogate compounds may be prepared by covalently joining two or more polypeptide epitopes using one or more linkers, wherein at least one of the epitopes comprises a post-translational modification. In one aspect, the surrogate compounds of the invention comprise a C-terminal epitope and a glycated epitope of human CD59. The inventive methods allow quantification of the levels of glycated CD59 in the serum in human subjects, particularly those with diabetes or pre-diabetes. This technological platform of post-translationally modified protein surrogates can be applied to other diseases associated with post-translationally modified proteins (e.g., autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus). In another aspect, the invention provides antibodies that bind specifically to the compounds of the invention and methods for producing such antibodies. | 2014-01-23 |
20140024057 | SYSTEMS AND METHODS FOR DETECTING ANIMAL PREGNANCY - Testing systems and methods are disclosed for detecting a pregnancy marker of an animal. A test kit may include a first standard with a first concentration of the marker, a second standard with a second concentration of the marker lower than the first concentration, and at least three test surfaces coated with a biomolecular recognition element selected to bind with the marker. The test may also include a reagent solution with a conjugated biomolecular recognition element that binds with the marker, and a visual indicator that produces a visually detectable change when reacting with the conjugated biomolecular recognition element bound to each test surface. A detectable change generated by the marker from the sample with an intensity greater than the first concentration yields a pregnant result, lower than the second concentration yields a not pregnant result, and between the first and second concentrations yields a retest result. | 2014-01-23 |
20140024058 | COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF - There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1). | 2014-01-23 |
20140024059 | APPARATUS AND METHODS FOR ANALYZING FLUID VARIABLES - Methods and devices for analyzing fluid variables. The devices analyze fluid variables by measuring cessation of fluid flow through the medium or a change in flow rate due to an inherent property of the fluid variable, or due to a modification of the fluid variable as the fluid migrates through the medium; or by measuring relative rates of capillary flow down two or more arms of a common element of porous media in some alternatives, converging in which at least one of the arms has been modified by the addition of flow-modifying agents which affect the flow rate in response to the concentration of the analyte; or by detecting changes in the rate of the capillary flow of the sample fluid along a path through an element of porous media, or through multiple elements of porous media. | 2014-01-23 |
20140024060 | USE OF HYDROGELS FOR BIOSENSORS HAVING ELEVATED SENSITIVITY - The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand. | 2014-01-23 |
20140024061 | DETECTION OF LCAT ACTIVITY - The present disclosure relates to methods for detecting and measuring the activity of lecithin:cholesterol acyltransferase (LCAT) in solution (e.g. serum, plasma, cell culture media, aqueous solution) with fluorescent sterol substrates. The present disclosure also relates to a method for evaluating efficacy of a therapeutic agent for stimulating LCAT and for determining endogenous LCAT activity in a patient. Also disclosed are kits that are used to carry out the aforementioned methods and methods. | 2014-01-23 |
20140024062 | AGENT FOR MEASURING ENDOTOXIN - A method for rapidly and highly sensitively measuring endotoxin is provided. Endotoxin is measured using an endotoxin-measuring agent comprising the proteins (1) to (3) below, each of which is a recombinant protein obtainable by being expressed using insect cells as a host: (1) a factor C derived from | 2014-01-23 |
20140024063 | METHODS AND COMPOUNDS FOR INCREASING SENSITIVITY OF BOTULINUM ASSAYS - Apparatus, systems and methods can provide improved detection of botulinum neurotoxins. In one aspect an isoquinolynyl compound can be used to enhance the sensitivity of both Förster resonance energy transfer (FRET) and non-FRET cell-based assays. In another aspect, non-FRET assays and constructs utilize a reporter that is not coupled with the second fluorophore in a manner that produces significant FRET. In that subject matter an environment cell can include an enzyme that facilitates degradation of the reporter significantly faster after the cleavage than before the cleavage, and presence of the Botulinum toxin correlates with reduction of the signal from a baseline signal. Where the environment is a cell, the cell can advantageously express both the construct that includes the reporter, and an enzyme that facilitates the degradation. | 2014-01-23 |
20140024064 | PROCESSES AND SYSTEMS FOR THE PRODUCTION OF FERMENTATIVE ALCOHOLS - The present invention relates to processes and systems for the production of fermentative alcohols such as ethanol and butanol. The present invention also provides methods for separating feed stream components for improved biomass processing and productivity. | 2014-01-23 |
20140024065 | EX VIVO METHOD FOR DETERMINING POTENTIAL GLP-2 RECEPTOR MODULATORS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 2014-01-23 |
20140024066 | ANIMAL MODEL HAVING PHOTO-ACTIVATABLE MITOCHONDRIA - An animal model includes a photo-activatable fluorescent protein that can conditionally label the mitochondria throughout the animal or in selective animal cells and tissues, allowing for effective studying of the mitochondria and tracking of mitochondrial dynamics. | 2014-01-23 |
20140024067 | KEX2 Cleavage regions of recombinant fusion proteins - The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5′ to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for enhancing the secretion and/or cleavage of a desired protein from a cell. | 2014-01-23 |
20140024068 | MULTICELLULAR SYSTEM AND METHOD FOR MULTIPARAMETRIC ANALYSIS - A system for multiparametric analysis includes a substrate and a three-dimensional (3D) cell aggregate. The substrate has a major surface and includes at least one radial electrode array. The 3D cell aggregate is disposed on the major surface of the substrate. The 3D cell aggregate has a longitudinal surface at least a portion of which covers one or more of the electrodes of the radial electrode array. | 2014-01-23 |
20140024069 | Biological Testing Device and Methods of Using and Testing - A biological sampling device for collecting biological material from within an organism can include a sheath, a collector, a handle, and optionally, an applicator. In a secured position, a collector is within the sheath and/or applicator; in a sampling position, a collector is outside the sheath and applicator. A device can be inserted into an orifice of an organism with a collector being transitioned from a secured to a sampling position, moved via a handle to collect biological material for testing, and subsequently returned to a secured position. A biological sample can be prepared from biological material collected by a biological sampling device, and a biological sample can be tested by application of a testing protocol. | 2014-01-23 |
20140024070 | METHOD FOR SCREENING FOR COMPOUND CAPABLE OF ENHANCING OR INHIBITING OATP1B1 TRANSPORT ACTIVITY, AND METHOD FOR DETERMINING EXPRESSION LEVEL OF OATP1B1 - The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofluorescein. The present invention further provides a use of a kit including dichlorofluorescein and positive cells expressing OATP1B1 in measurement of the expression level of OATP1B1 in test cells. | 2014-01-23 |
20140024071 | PHOTO-UNCAGING-ASSISTED EVALUATION OF LARGE-SCALE SYNAPTIC REORGANIZATION OF BRAIN CIRCUITS - Photouncaging-assisted evaluation of large-scale synaptic reorganization of brain circuits and methods in use thereof. The current invention utilizes laser-scanning photostimulation in large-scale and with higher accuracy to detect synaptic reorganization in neurological disorders, such as Alzheimer's disease, Parkinson's disease and epilepsy. Using the invention's methodology, disease and non-disease conditions can be determined, and treatments can be personalized and administered more efficiently. | 2014-01-23 |
20140024072 | SAMPLE ANALYZER, SAMPLE INFORMATION PROCESSING APPARATUS, AND SAMPLE ANALYSIS METHOD - A sample analyzer includes: a first measurement part which performs measurement on a sample for a first measurement item; a second measurement part which performs a measurement on the sample for a second measurement item; an output section; and a controller configured to control the output section to output, when a time difference between a measurement on a sample performed by the first measurement part and a measurement on the sample performed by the second measurement part exceeds a predetermined time period, information based on an excess of the time difference. | 2014-01-23 |
20140024073 | BIO-MEMS FOR DOWNHOLE FLUID ANALYSIS - A method and apparatus for observing a biological microelectromechanical systems response to a fluid including combining an activator and a fluid wherein the fluid comprises a component from a subterranean formation, exposing the combined activator and fluid to a sensor in a wellbore to observe a biological microelectromechanical systems response, and integrating data from the observing with petrophysical data. A method and apparatus for observing a biological microelectromechanical systems response to a fluid including a housing comprising a biological microelectromechanical observation material, a signal analyzer in communication with the material, and a fluid preparation device positioned to allow fluid to flow to the surface, wherein the fluid comprises a component from a subterranean formation. | 2014-01-23 |
20140024074 | YEAST CONCENTRATION AND VIABILITY MEASUREMENT - The invention generally relates to analyzing yeast viability. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring viability and concentration of yeast cells. | 2014-01-23 |
20140024075 | BACTERIAL CULTURE MEDIA AND METHODS FOR THEIR PREPARATION AND USE - Provided herein are methods and compositions for bacterial cellulose production. In some embodiments, the methods and compositions involve or are made from distiller's grain. | 2014-01-23 |
20140024076 | Expression Of Soluble Viral Fusion Glycoproteins In Mammalian Cells - The technology relates in part to production (i.e., expression) of recombinant viral fusion glycoproteins and nucleic acids that encode such viral fusion glycoproteins. In some embodiments, human respiratory syncytial virus fusion protein (RSV-F) and human parainfluenza virus 3 fusion protein (hPIV3-F) are expressed. | 2014-01-23 |
20140024077 | ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN IL-6 - The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules. | 2014-01-23 |
20140024078 | PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA - The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of recombinant proteins, such as antibodies, in asparagine-supplemented glutamine-free mammalian cell culture. | 2014-01-23 |
20140024079 | METHODS FOR PRODUCING BIOLOGICAL MATERIALS - Methods of producing biological materials from cells and organisms are provided. Aspects of the methods include modulating the stress conditions of the cells and/or organism to produce biological materials having one or more desired properties. In certain aspects, the cell or organism is evaluated to detect the presence or absence of a stressed phenotype, wherein an unstressed phenotype may be produced before the cell or organism produces the biological material of interest. The biological materials produced from such cells and organisms may be used for a variety of applications, including therapeutic, research, and other applications. | 2014-01-23 |
20140024080 | MICROBIAL METHOD FOR THE BIOTRANSFORMATION OF COLCHICINOID COMPOUNDS - The invention relates to a method for the Bio-transformation of Thiocolchicine a colchicinoid compound into its glycosylated form using a selective microorganism | 2014-01-23 |
20140024081 | Methods and Compositions for Dengue Virus 3 (DV3) Infectious Clone - The present invention provides a nucleic acid molecule comprising a nucleotide sequence encoding an infectious RNA molecule encoding a live viral strain of a dengue 3 virus (DV3), wherein said nucleotide sequence is the nucleotide sequence of SEQ ID NO:1 or a nucleotide sequence having at least 99% identity with the nucleotide sequence of SEQ ID NO.1. | 2014-01-23 |
20140024082 | Activated Sugars - Kinase and nucleotidyltransferase enzymes for the production of activated sugars have been developed. These enzymes have improved stability for industrial application and relaxed specificity towards a variety of sugars. These enzymes are useful in, for example, the production of diverse NDP-sugars for glycosylation of aglycones of interest, production of oligosaccharides, production of other important glycosylated sugars, and in drug discovery applications. | 2014-01-23 |
20140024083 | Alpha-Amylase Mutants - The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to the parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca | 2014-01-23 |
20140024084 | MATERIALS AND METHODS FOR CONVERTING BIOMASS TO BIOFUEL - This disclosure provides for materials and methods for converting biomass to biofuels. The materials include a colloid mill with or without cellulase enzymes, and the methods include the use of a colloid mill and optionally cellulose enzymes to pretreat biomass for use in a biomass to biofuel production process. | 2014-01-23 |
20140024085 | Cultivation of micro-algae and application to animal feeds, environments, field crops, and waste treatment - The present disclosure concerns producing a micro-algae product. In preferred embodiments, the method comprises collecting urine from lactating cows, mixing the collected urine with aerobically digested cow manure to form a mother liquor, fermenting the mother liquor in an algae growth tank; and forming two distinct layers of top water, including a top water layer, the top-water layer including yeast by-products and algae by-products. | 2014-01-23 |
20140024086 | OVER-EXPRESSION OF NADH-DEPENDENT OXIDOREDUCTASE (FUCO) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE - The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product. | 2014-01-23 |
20140024087 | MICROORGANISM HAVING ENHANCED L-AMINO ACIDS PRODUCTIVITY AND PROCESS FOR PRODUCING L-AMINO ACIDS USING THE SAME - A microorganism of the genus | 2014-01-23 |
20140024088 | PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF - Process for the enzymatic synthesis of the compound of formula (I), (7S)-1-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)N-methyl methanamine: | 2014-01-23 |
20140024089 | MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY - The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids. | 2014-01-23 |
20140024090 | METHOD AND APPARATUS FOR CONVERTING A CARBON SOURCE INTO A HYDROCARBON OR HYDROCARBON PRECURSOR - Method for converting a carbon source such as a plant-derived material into a hydrocarbon or hydrocarbon precursor, via a microorganism-catalysed aerobic reaction. The microorganism is cultivated in the presence of the carbon source and of oxygen, in a reaction vessel having a capacity of about 2000 litres or greater which comprises an aeration system for supplying oxygen to the microorganism. Also provided is an apparatus for use in the method, comprising a reaction vessel of capacity 2000 litres or greater, and an aeration system. | 2014-01-23 |
20140024091 | USE OF OXYHYDROGEN MICROORGANISMS FOR NON-PHOTOSYNTHETIC CARBON CAPTURE AND CONVERSION OF INORGANIC AND/OR C1 CARBON SOURCES INTO USEFUL ORGANIC COMPOUNDS - Compositions and methods for a hybrid biological and chemical process that captures and converts carbon dioxide and/or other forms of inorganic carbon and/or C1 carbon sources including but not limited to carbon monoxide, methane, methanol, formate, or formic acid, and/or mixtures containing C1 chemicals including but not limited to various syngas compositions, into organic chemicals including biofuels or other valuable biomass, chemical, industrial, or pharmaceutical products are provided. The present invention, in certain embodiments, fixes inorganic carbon or C1 carbon sources into longer carbon chain organic chemicals by utilizing microorganisms capable of performing the oxyhydrogen reaction and the autotrophic fixation of CO | 2014-01-23 |
20140024092 | MODIFIED 13-HYDROPEROXIDE LYASES AND USES THEREOF - Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis. | 2014-01-23 |
20140024093 | PROCESS FOR THE PRODUCTION OF DIGESTED BIOMASS USEFUL FOR CHEMICALS AND BIOFUELS - In the pretreatment, the biomass is contacted with a solution containing at least one α-hydroxysulfonic acid thereby at least partially hydrolyzing the biomass to produce a pretreated stream containing a solution that contains at least a portion of hemicelluloses and a residual biomass that contains celluloses and lignin; separating at least a portion of the solution from the residual biomass providing an solution stream and a pretreated biomass stream; then contacting the pretreated biomass stream with a cooking liquor containing at least one alkali selected from the group consisting of sodium hydroxide, sodium carbonate, sodium sulfide, potassium hydroxide, potassium carbonate, ammonium hydroxide, and mixtures thereof and water. A process that allows for higher recovery of carbohydrates and thereby increased yields is provided. Alcohols useful as fuel compositions are also produced from biomass by pretreating the biomass prior to hydrolysis and fermentation. | 2014-01-23 |
20140024094 | INCREASED PRODUCTION OF ISOBUTANOL IN YEAST WITH REDUCED MITOCHONDRIAL AMINO ACID BIOSYNTHESIS - Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase. | 2014-01-23 |
20140024095 | ACETATE RESISTANCE IN YEAST BASED ON INTRODUCTION OF A MUTANT HAA1 ALLELE - Improved haa1 transcriptional regulatory proteins, polynucleotides encoding improved haa1 transcriptional regulatory proteins and vectors and cells thereof are provided, as well as methods for converting a cellulose-containing biomass feedstock to ethanol using improved haa1 transcriptional regulatory proteins and cells expressing heterologous haa1 transcriptional regulatory proteins as disclosed herein. | 2014-01-23 |
20140024096 | METHOD FOR CONVERTING BIOMASS TO METHANE OR ETHANOL - A method for enhancing the treatment of lignocellulose-containing materials by biotreatment wherein such lignocellulose-containing materials, normally resistant to biotreatment, are first subjected to a low-temperature, long-residence time pyrolysis at about 175° C. to about 325° C. for about 0.1 hour to about 2.0 hours, wherein a substantial portion of the incoming material is distilled into water-soluble compounds amenable to anaerobic biotreatment. Exemplary applications of the method include pyrolytic pre-treatment of wastewater sludges, cellulosic wastes, wood, peat, plant residues, low-grade coal, and the like to enhance methane gas production in anaerobic digestion and/or oxygen-limited or oxygen-starved fermentation to produce ethanol. | 2014-01-23 |
20140024097 | YEAST MUTANT OF KLUYVEROMYCES AND METHOD FOR ETHANOL PRODUCTION USING THE SAME - A yeast of the genus | 2014-01-23 |
20140024098 | EXPRESSION OF CATALASE IN TRICHODERMA - The invention provides methods for expression of a catalase enzyme in a | 2014-01-23 |
20140024099 | Biomarkers for Non-Hodgkin Lymphomas and Uses Thereof - The disclosure provides a method of identifying a subject as having B-cell non-Hodgkin lymphoma (NHL) such as testing a sample from a subject for a mutation in one or more biomarkers. Also described are methods for classifying or monitoring a subject having, or suspected of having, B-cell non-Hodgkin lymphoma comprising testing the sample for a mutation in one or more biomarkers. | 2014-01-23 |
20140024100 | MEASLES VIRUSES WITH REDUCED SUSCEPTIBILITY TO NEUTRALIZATION - This document provides methods and materials for making and using measles viruses having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by monoclonal anti-measles virus antibodies and/or serum from measles virus vaccinees). For example, H polypeptides having a reduced ability of being recognized by anti-measles virus antibodies that were generated against a wild-type measles virus or a pre-existing measles virus vaccine such as MV-Edm as compared to a wild-type measles virus H polypeptide or the H polypeptide of MV-Edm are provided. | 2014-01-23 |
20140024101 | METHOD FOR INCREASING THE REPLICATION CAPACITY OF AN INFLUENZA VIRUS IN CULTURED CELLS - The present invention relates to methods for increasing the replication capacity of an influenza virus in cultured cells. More particularly, the present invention relates to a method for increasing the replication capacity of an influenza virus in a cell comprising the steps consisting of i) infecting said cell with said influenza virus and ii) culturing said infected cell with a least one molecule selected from the group consisting of Dibucaine, Aprindine, Amiloride, Mevinolin, Simvastatin, Promathazine, Pranlukast, Nimodipine, Ibutilide hemifumarate Salt, Risperidone and derivatives or analogues thereof. | 2014-01-23 |
20140024102 | MICROBIAL FUEL CELL, FUEL AND MICROBES FOR SAID FUEL CELL, BIOREACTOR AND BIOSENSOR - As a technique for increasing the output of a microbial fuel cell, a microbial fuel cell including a polyol such as glycerol as a fuel and using a microbe in which an enzyme that catalyzes a redox reaction has been introduced by genetic recombination on the side of a negative electrode is provided. By this microbial fuel cell, the velocity of the reaction can be increased to thereby give a high output by retaining a microbe in which an enzyme that catalyzes a redox reaction such as diaphorase has been introduced by genetic recombination on the side of the negative electrode. | 2014-01-23 |
20140024103 | Detergent Compositions Comprising Metalloproteases - The present invention relates to cleaning and/or detergent compositions comprising metalloproteases (E.C 3.4.24). The invention further concerns the use of the metalloproteases in cleaning processes, such as dish wash and laundry, and in particular to the use in low temperature wash and in removal of egg stains. Further the invention concerns methods of doing cleaning, such as dish wash and laundry. | 2014-01-23 |
20140024104 | METHOD FOR RECOVERING PLANT-DERIVED PROTEINS - Methods of recovering plant-derived proteins or suprastructure proteins, are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized proteins, or suprastructure proteins, loosening the cell wall to produce a plant or plant matter having a loosened cell wall, thus allowing the release of apoplastic content through the cell wall to produce an apoplastic content fraction from the plant or plant matter, and recovering the apoplastic content fraction. The apoplastic content fraction comprises plant-derived proteins or suprastructure proteins. | 2014-01-23 |
20140024105 | Baffled Single Use Bioreactor - A flexible disposable bioreactor having three, stagger-baffled compartments wherein the middle compartment houses a sparging rod is described to provide the highest degree of sparging and mixing to produce biological products. | 2014-01-23 |
20140024106 | MONITORING OF WOUNDS BY MEASUREMENT OF PROTEASE AND PROTEASE INHIBITOR LEVELS IN WOUND FLUIDS - A diagnostic test apparatus for determining a ratio of: (a) at least one endogenous protease enzyme inhibitor, to (b) at least one endogenous protease enzyme, in a sample of a wound fluid. Suitably the protease enzyme is a neutrophil elastase and the protease enzyme inhibitor is alpha-1-antitrypsin. Also provided are wound treatment systems comprising an apparatus according to the invention and a wound dressing comprising an oxidized cellulose. Also provided are methods of diagnosis, prognosis and treatment of wounds using the apparatus and systems of the invention. | 2014-01-23 |
20140024107 | COMPACT AUTOMATED CELL COUNTER - Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm | 2014-01-23 |
20140024108 | Apparatus for Production of Biogas by Digestion of Organic Material - An apparatus for production of a biogas by anaerobic digestion of organic material, the apparatus comprising: a digester chamber defining: a gas generating zone and a gas collecting zone. A biogas outlet is defined in the gas collecting zone, and one or more nozzles is/are arranged to spray a gas cooling liquid into the gas accommodated in the gas collecting zone so as to cool the gas. A collecting member is arranged in the gas collecting zone to collect the gas cooling liquid when sprayed from the one or more nozzles towards the collecting member so as to prevent the gas cooling liquid from entering the organic material. The collecting member is arranged to cause the collected gas cooling liquid to flow into a liquid based safety valve. | 2014-01-23 |
20140024109 | GRAVITY ASSISTED COMPOST REACTOR - A composting system is provided that uses gravity and natural thermal convection to yield a compact, modular, plug-flow compost reactor requiring minimal aeration and agitation energy. The compost reaction takes place in a self-supporting containment unit which is mounted at an angle with respect to its supporting base pad such that minimal external energy is required to mix and transport the composting material during its residence time within the container. The system uses natural convection to supplement external energy in the introduction of air into and through the material. Furthermore, the configuration of the containment unit and its supporting structures allow rapid deployment of compost facilities with minimal permanent civil work and minimal space requirements in a manner that enables subsequent relocation of the equipment. | 2014-01-23 |
20140024110 | Operating Apparatus for the Control of a Movement Apparatus and Method - The invention relates to operating apparatus for the control of a movement apparatus, in particular the movement apparatus of a micromanipulator for the manipulation of biological cells, and a method for the control of the movement apparatus. The operating apparatus comprises an electrical control device and an input device with different input zones, by means of which the movement apparatus can be controlled according to different control rules. | 2014-01-23 |
20140024111 | HOST CELL FOR MAKING ANTIBODY FC-HETERODIMERIC MOLECULES USING ELECTROSTATIC STEERING EFFECTS - The invention relates to methods of making Fc-heterodimeric proteins or polypeptides. The invention also relates to the Fc-heterodimeric proteins or polypeptides themselves, including the individual polypeptide components that comprise the heterodimer Nucleic acids encoding such polypeptides, expression vectors, and host cells. Moreover, the invention relates to pharmaceutical compositions comprising one of more Fc-heterodimeric proteins or polypeptides. | 2014-01-23 |
20140024112 | IN-VIVO BIOREACTOR SYSTEM AND METHOD FOR TISSUE ENGINEERING - An in-vivo bioreactor system includes a base, a chamber, an access member, an inlet port, an outlet port, and a transparent viewing member. The base includes an internal base cavity. The chamber attaches and detaches from the base. The chamber includes an internal chamber cavity which is in communication with the internal base cavity when the chamber is attached to the base. The access member when disposed in an open position allows access to the internal base cavity or the internal chamber cavity from outside the in-vivo bioreactor system. The inlet port is in communication with the internal base cavity or the internal chamber cavity. The outlet port is in communication with the internal base cavity or the internal chamber cavity. The transparent viewing member allows viewing of the internal base cavity or the internal chamber cavity from outside the in-vivo bioreactor system. | 2014-01-23 |
20140024113 | COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES - This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins. It inhibits excess adhesion and inhibits cell attachment. It modulates angiogenesis. The compounds also use as mediator of cell adhesion receptor, cell circulating, cell moving and inflammatory diseases. | 2014-01-23 |
20140024114 | COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM - Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentiated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described. | 2014-01-23 |
20140024115 | METHODS OF COMBINING MESENCHYMAL STEM CELLS AND CARTILAGE CONTAINING ALLOGRAFTS, AND PRODUCTS OF COMBINED MESENCHYMAL STEM CELLS AND CARTILAGE CONTAINING ALLOGRAFTS - There is disclosed a method of combining mesenchymal stem cells (MSCs) with an osteochondral allograft. In an embodiment, the method includes obtaining adipose tissue having MSCs with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The suspension is added to seed the allograft. The MSCs are allowed to attach to the allograft. There is disclosed an allograft product including MSCs with an osteochondral allograft. There is disclosed a method of combining MSCs with decellularized, morselized cartilage. In an embodiment, the method includes obtaining adipose tissue having MSCs with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The suspension is added to seed the cartilage. The MSCs are allowed to attach to the cartilage to. There is disclosed an allograft product including MSCs with morselized cartilage. Other embodiments are also disclosed. | 2014-01-23 |
20140024116 | Non-Static Suspension Culture of Cell Aggregates - The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells. | 2014-01-23 |
20140024117 | Extracellular Matrix Films And Methods Of Making And Using Same - In one aspect, films that can serve as a model or mimic for the basal lamina are described herein. In some embodiments, a film described herein comprises a top surface and a bottom surface in facing opposition to the top surface, wherein the film is formed from Type I collagen and one or more additional extracellular matrix proteins. The additional extracellular matrix proteins, in some cases, comprise one or more of Type IV collagen, laminin, and fibronectin. Moreover, in some instances, the weight ratio of Type I collagen to the additional extracellular matrix proteins in the film is at least about 40:1. | 2014-01-23 |
20140024118 | HUMAN ERYTHROID PROGENITOR CELL LINE AND METHOD FOR PRODUCING HUMAN ENUCLEATED RED BLOOD CELLS - Provided are: a method for producing an immortalized human erythroid progenitor cell line, enabling efficient and stable production of enucleated red blood cells; and a method for producing human enucleated red blood cells from a human erythroid progenitor cell line obtained by the aforementioned production method. An expression cassette capable of inducing expression of HPV-E6/E7 genes in the presence of DOX was introduced into the genomic DNA of blood stem cells. Then, the blood stem cells were cultured in the presence of DOX and a blood growth factor. Thereby, immortalized cell lines of human erythroid progenitor cells were established. Further, it was revealed that culturing the cell lines under a condition where the expression of the HPV-E6/E7 genes was not induced enabled differentiation induction into enucleated red blood cells at a high ratio. | 2014-01-23 |
20140024119 | CELL REPROGRAMMING COMPOSITION COMPRISING REX1 AND AN INDUCED PLURIPOTENT STEM CELL PRODUCTION METHOD USING THE SAME - A reprogramming inducing composition including the Rex1 protein or a nucleic acid molecule coding for the Rex1 protein for producing induced pluripotent stem cells from body cells or non-embryonic cells through a reprogramming process. A method for producing induced pluripotent stem cells by using the Rex1 is also disclosed. | 2014-01-23 |
20140024120 | AUTOMATED PROTEIN ANALYZER - A dye binding method for protein analysis is disclosed. The method includes the steps of preparing an initial reference dye solution of unknown concentration from an initial reference dye concentrate and creating an electronic signal based upon the absorbance of the initial reference dye solution. Thereafter, an electronic signal is created based upon the absorbance of a dye filtrate solution prepared from the initial reference dye solution and an initial protein sample. The absorbance signals from the reference dye solution and the dye filtrate solution are sent to a processor that compares the respective absorbances and calculates the protein content of the protein sample based upon the difference between the absorbances. An electronic signal is created based upon the absorbance of a successive dye filtrate solution prepared from the reference dye solution and a successive protein sample, and the absorbance signal from the successive sample dye filtrate solution is sent to the processor to calculate the protein content of the successive sample based upon the difference between the absorbance of the initial reference dye solution and the absorbance of the successive dye filtrate solution. | 2014-01-23 |
20140024121 | METHOD FOR PREDICTING THE EFFICIENCY OF A TiO2 PHOTOCATALYST - The present invention relates to a method for predicting the efficiency of a TiO | 2014-01-23 |
20140024122 | ANALYTE DETECTION USING LIQUID CRYSTALS - Devices and methods for using changes in the defects in micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide (LPS), are disclosed. The dispersed liquid crystal microdomains are exposed to the test sample, and any changes in the number of defects in the liquid crystal microdomains are detected by detecting changes in the anchoring configuration of the microdomains. Such changes in anchoring configuration indicate the presence of analyte in the test sample. | 2014-01-23 |
20140024123 | Aqueous Solution Containing Partial Ras Polypeptide and Method for Screening Inhibitor of Ras Function - Provided is a screening method for a more effective Ras inhibitor. Further provided are amino acid residues at a site important for an interaction with a Ras inhibitor in a Ras polypeptide. By confirming a difference between structural information on the Ras polypeptide by NMR and structural information between a complex of the Ras polypeptide and a seed compound by NMR, a more effective lead compound than the seed compound can be selected. As a result of analysis based on the structural information on the Ras polypeptide by NMR, the amino acid residues capable of interacting with a Ras inhibitor candidate (a) are K5, E37, D38, S39, L56, E63, Y64, A66, M67, Q70, Y71, R73, and T74 with reference to an amino acid sequence set forth in SEQ ID NO: 1. | 2014-01-23 |
20140024124 | LABELING AGENT FOR ANALYZING POST-TRANSLATIONAL MODIFICATIONS OF SERINE AND THREONINE - A glycoprotein and/or a glycopeptide which are a test substance is heated in the presence of a pyrazolone derivative, an isoxazolone derivative, a hydantoin derivative, a rhodanine derivative, a maleimide derivative, or the like under a basic condition to cleave and label a post-translational modification group for analysis, thereby enabling analysis of a post-translational modification of a serine residue and/or a threonine residue. | 2014-01-23 |
20140024125 | STUDY OF POLYMER MOLECULES AND CONFORMATIONS WITH A NANOPORE - The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer. | 2014-01-23 |
20140024126 | FLOW-CHANNEL DEVICE FOR DETECTING LIGHT EMISSION - The present invention provides a flow-channel device for detecting light emission, which suppresses a noise originating in unnecessary light emission, and can be simply bonded with the use of an organic material. The flow-channel device having a flow channel is structured by the bonding of at least two substrates, wherein at least any one substrate has a first groove which constitutes the flow channel, and a second groove for arranging an adhesive therein which contains an organic material, and a light-shielding layer is provided on an inner wall of the second groove so as to block a light emitted from the second groove from penetrating into the first groove. | 2014-01-23 |
20140024127 | METHODS FOR RECOVERING AND ANALYZING AMINES - The objects of embodiments in the present disclosure are to provide a method capable of recovering two or more amine compounds at the same time from a gas or solution, and also to provide a method capable of analyzing the recovered amines. | 2014-01-23 |
20140024128 | METHOD OF DETECTING NITROGEN COMPOUNDS CONTAINED IN EXHAUST GASES, NOTABLY OF INTERNAL-COMBUSTION ENGINES - A method of detecting nitrogen compound emissions in exhaust gases treated with selective catalytic reduction achieved by injecting a reducing agent into the gases and by passing these gases through a catalyst
| 2014-01-23 |
20140024129 | Systems and Methods for Measuring Total Sulfur Content in a Fluid Stream - A system for determining the content of sulfur in a first fluid mixture includes a gas chromatograph including a sample valve, a first column coupled to the sample valve, and a second column coupled to the sample valve. In addition, the system includes a pyrolizer configured to subject the first fluid mixture to pyrolysis to produce a second fluid mixture that includes hydrogen sulfide. The first column is configured to separate at least a first constituent of the second fluid mixture from the hydrogen sulfide in the second fluid mixture and output a third fluid mixture including the hydrogen sulfide. The second column is configured to separate at least a second constituent in the third fluid mixture from the hydrogen sulfide in the third fluid mixture and output a fourth fluid mixture including the hydrogen sulfide. Further, the system includes a detector in fluid communication with the second column. | 2014-01-23 |
20140024130 | CHEMICAL BREATH TESTING DEVICE FOR DETECTING ALCOHOL INCLUDING A TESTING TUBE AND AN INFLATABLE BAG - The invention relates to a chemical breath testing device including a transparent testing tube which cooperates with an outlet piece incorporating a valve and fitted to an inflatable bag. The testing tube is provided with a member for pushing the valve which is formed by the bottom of a cap. The outer sidewall of the cap is resiliently deformable and serves to form an interlocking connection between the testing tube and the outlet piece. The cap is mounted in a mobile manner at the end of the testing tube and carries a cutting blade for cutting a seal closing off the outlet of the testing tube, of which the rim forms a counter-blade. | 2014-01-23 |
20140024131 | HYBRID NANOSTRUCTURES FOR MOLECULAR ANALYSIS - A hybrid nanostructure for molecular analysis is disclosed. The structure includes a plurality of nanofingers wherein each nanofinger is coated with a metal coating, is attached at one end to a substrate, and is freely bendable along its length such that the second ends of each nanofinger are capable of movement toward each other to form a cavity. The structure further includes a nanoparticle trapped in the cavity. An array of hybrid nanostructures and a method for fabricating the hybrid nanostructures are also disclosed. | 2014-01-23 |
20140024132 | METHODS AND SYSTEMS USING INTEGRATED METABOLOMICS AND PHARMACOKINETICS FOR MULTI-COMPONENT DRUG EVALUATION - Disclosed are methods and systems for identifying biochemical changes in a subject in response to administration of a multi-component therapeutic and one or more active ingredients in the multi-component therapeutic. The methods and systems of the invention may be used to elucidate the interaction of the biological system's genome with its environments, and in the pharmacokinetic, pharmacodynamic and toxicology analysis of multi-component therapeutics. The metabolomics methods and systems of the invention can also be used in studies of plant derived agents to demonstrate biochemical alterations in response to the dynamic multi-component intervention. | 2014-01-23 |
20140024133 | METHOD FOR OPTIMIZING VERTICAL PROBE ALIGNMENT USING DIAGNOSTIC MIXING ROUTINES - A method and apparatus for adjusting the height of a tip of a mixing element, such as a needle probe, compares the mixing efficiency observed at two heights separated by a predetermined distance. The heights can be incrementally adjusted to determine the location of the bottom of a mixing vessel and, by extension, the approximate location for placing the mixing element for efficient mixing of solutions in the mixing vessel. | 2014-01-23 |
20140024134 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used. | 2014-01-23 |
20140024135 | MICRO PLATE TREATING DEVICE AND MICRO PLATE TREATING METHOD - An object is to provide a micro plate treating device and micro plate treating method capable of handling a larger number of kinds of solution or suspensions or a larger volume of solutions or suspensions per work area by use of a normalized micro plate without enlarging the scale of the device. The micro plate treating device comprises a micro plate having wells arranged in a matrix form, one or two or more nozzle heads each having nozzles capable of sucking and discharging a fluid and arranged in a matrix form, and moving means capable of moving relatively an interval between the micro plate and the nozzle heads, wherein tips of all the nozzles are configured to be permitted to be simultaneously inserted into some of the wells in the micro plate, at least one of the row interval or the column interval of the nozzles is set to a natural number multiple of the row interval or the column interval of the corresponding wells, the natural number being two or more, and at least one of the row number or the column number of all the corresponding nozzles is one to the natural number of the row number or the column number of the wells. | 2014-01-23 |
20140024136 | MAGNETIC PARTICLE SEPARATOR - A magnetic particle separator ( | 2014-01-23 |
20140024137 | METHODS AND COMPOSITIONS RELATED TO NUCLEIC ACID BINDING ASSAYS - Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids. | 2014-01-23 |
20140024138 | METHOD FOR ETCHING METAL LAYER AND METHOD FOR MANUFACTURING A SEMICONDUCTOR DEVICE USING THE SAME - The inventive concepts disclosed herein include, for instance, methods for etching a metal layer and methods for manufacturing a semiconductor device using the etched metal layer. A wafer including a metal layer and a mask layer on the metal layer may be loaded into a process chamber. An etching gas may be supplied into the process chamber to etch the metal layer exposed by the mask layer. After the etching process, the mask layer may be removed. The etching gas can include phosphorus (P) and fluorine (F). An RF power may be constantly or selectively supplied to the process chamber, or different levels of RF power can be selectively supplied. An etching gas can be supplied to the process chamber when the RF power is off or at a lower level. A surface activation gas can be supplied when the RF power is on or at a higher level. | 2014-01-23 |
20140024139 | Hole First Hardmask Definition - A semiconductor device and a method of manufacture are provided, such as a MTJ device and a method of manufacturing a MTJ device. The MTJ device may include a bottom electrode, a MTJ stack, and a top electrode, wherein the top electrode is formed using a hole-filling technique. The top electrode may have slanted sidewalls. The MTJ stack may be formed by depositing corresponding MTJ layers. A patterned mask may be formed and patterned over the MTJ layers to form an opening defining the top electrode. The opening is filled with a conductive material to form the top electrode. The top electrode is then used as a mask to pattern the MTJ layers, thereby forming a MTJ stack. | 2014-01-23 |
20140024140 | MAGNETORESISTANCE EFFECT DEVICE AND METHOD OF PRODUCTION OF THE SAME - A magnetoresistance effect device including a multilayer structure having a pair of ferromagnetic layers and a barrier layer positioned between them, wherein at least one ferromagnetic layer has at least the part contacting the barrier layer made amorphous and the barrier layer is an MgO layer having a highly oriented texture structure. | 2014-01-23 |
20140024141 | STT-MRAM CELL STRUCTURES - A magnetic cell structure including a nonmagnetic bridge, and methods of fabricating the structure are provided. The magnetic cell structure includes a free layer, a pinned layer, and a nonmagnetic bridge electrically connecting the free layer and the pinned layer. The shape and/or configuration of the nonmagnetic bridge directs a programming current through the magnetic cell structure such that the cross sectional area of the programming current in the free layer of the structure is less than the cross section of the structure. The decrease in the cross sectional area of the programming current in the free layer enables a lower programming current to reach a critical switching current density in the free layer and switch the magnetization of the free layer, programming the magnetic cell. | 2014-01-23 |
20140024142 | SPECTRAL REFLECTOMETRY WINDOW HEATER - A plasma processing tool for fabricating a semiconductor device on a semiconductor wafer includes an optical window disposed on a plasma chamber, remotely from a plasma region. The window is thermally connected to an electrical heater element capable of maintaining the window at a temperature of at least 30° C. A heater controller provides electrical power to the heater element. During operation of the plasma processing tool, the heater controller provides power to the heater element so as to maintain the window at a temperature of at least 30° C. during at least a portion of a plasma process step in which by-products are produced in the plasma chamber. | 2014-01-23 |
20140024143 | SYSTEM FOR IN-SITU FILM STACK MEASUREMENT DURING ETCHING AND ETCH CONTROL METHOD - Disclosed is an in-situ optical monitor (ISOM) system and associated method for controlling plasma etching processes during the forming of stepped structures in semiconductor manufacturing. The in-situ optical monitor (ISOM) can be optionally configured for coupling to a surface-wave plasma source (SWP), for example a radial line slotted antenna (RLSA) plasma source. A method is described to correlate the lateral recess of the steps and the etched thickness of a photoresist layer for use with the in-situ optical monitor (ISOM) during control of plasma etching processes in the forming of stepped structures. | 2014-01-23 |
20140024144 | INTEGRATED CIRCUIT DIE AND METHOD OF MAKING - Integrated circuit dies and methods of making dies are disclosed. An embodiment of a die includes at least one transistor gate, wherein the gate has an area. A conductor is connected to the gate, and wherein the conductor has an area. The area of the conductor is proportional to the area of the gate raised to a power, wherein the power is a function of the failure rate of the gate. | 2014-01-23 |
20140024145 | METHOD AND STRUCTURE FOR MULTI-CORE CHIP PRODUCT TEST AND SELECTIVE VOLTAGE BINNING DISPOSITION - Operating speeds of integrated circuit devices are tested to establish maximum and minimum frequency at maximum and minimum voltage. The devices are sorted into relatively-slow and relatively-fast devices to classify the devices into different voltage bins. A bin-specific voltage limit is established for each of the voltage bins needed for core performance at system use conditions. The bin-specific voltage limit is compared to core minimum chip-level functionality voltage at system maximum and minimum frequency specifications. The method correlates system design evaluation of design maximum and minimum frequency at design maximum and minimum voltage conditions with evaluation of tested maximum and minimum frequency at tested maximum and minimum voltage conditions. A chip-specific functionality voltage limit is established for the device. Initial system voltage for all devices from a voltage bin is set at a greater of the bin-specific voltage limit and the chip-specific functionality voltage limit consistent with the evaluation conditions. | 2014-01-23 |
20140024146 | SEMICONDUCTOR STRUCTURE - A semiconductor structure is provided and includes a substrate having an edge surface and a device surface with a central area, a crack stop structure disposed on the device surface and a circuit structure including components disposed on the device surface in the central area and interconnects electrically coupled to the components. The interconnects are configured to extend from the central area to the edge surface while bridging over the crack stop structure. | 2014-01-23 |
20140024147 | CORRUGATED MEMBRANE MEMS ACTUATOR FABRICATION METHOD - A MEMS device fabrication method includes providing a substrate and a chamber wall material layer on a first surface of the substrate, the chamber wall material layer including a chamber cavity having a sacrificial material located therein. A mask material is deposited on the chamber wall material layer and the sacrificial material and patterned to form a mask pattern including a plurality of discrete portions. The mask material and some of the sacrificial material are removed to transfer the mask pattern including the plurality of discrete portions to the sacrificial material. A membrane material layer is deposited on the chamber wall material layer and the sacrificial material that includes the transferred mask pattern including the plurality of discrete portions. Some of the substrate and the sacrificial material are removed to release the membrane material layer using at least one process initiated from a second surface of the substrate. | 2014-01-23 |
20140024148 | METHOD OF MANUFACTURING SUBSTRATE OF LIQUID EJECTION HEAD - A method of manufacturing a substrate of a liquid ejection head including: forming a plurality of recesses in a silicon wafer; etching the silicon wafer with etchant to form a depression and a plurality of through holes formed from the plurality of the recesses in the depression; and manufacturing a plurality of substrates of the liquid ejection head from the silicon wafer by dividing the silicon wafer on the basis of through holes. | 2014-01-23 |
20140024149 | Low-Profile MEMS Thermal Printhead Die Having Backside Electrical Connections - A thermal printhead die is formed from an SOI structure as a MEMS device. The die has a printing surface, a buried oxide layer, and a mounting surface opposite the printing surface. A plurality of ink delivery sites are formed on the printing surface, each site having an ink-receiving and ink-dispensing structure. An ohmic heater is formed adjacent to each structure, and an under-bump metallization (UBM) pad is formed on the mounting surface and is electrically connected to the ohmic heater, so that ink received by the ink-delivery site and electrically heated by the ohmic heater may be delivered to a substrate by sublimation. A through-silicon-via (TSV) plug may be formed through the thickness of the die and electrically coupled through the buried oxide layer from the ohmic heater to the UBM pad. Layers of interconnect metal may connect the ohmic heater to the UBM pad and to the TSV plug. | 2014-01-23 |