01st week of 2010 patent applcation highlights part 42 |
Patent application number | Title | Published |
20100004109 | CENTRIFUGE CUP - The invention relates to a centrifuge cup, which has a container and a cover. The cover has a lever including a guide element in each case on opposing edge areas thereof. The guide elements are able to be introduced into an associated guide path of the container by pivoting the lever. The guide elements are implemented in such a way that in a closed state of the cover with the container, a clamping force (F) having vertical force component (F | 2010-01-07 |
20100004110 | Method for Making Glass Frit Powders Using Aerosol Decomposition - The invention relates to a corrosion resistant reactor tube, method for providing a passivating or corrosion resistant coating to the inside of the reactor tube, and a method of making high bismuth glass powders using the corrosion resistant reactor tube. | 2010-01-07 |
20100004111 | Antimicrobial Glass and Method of Producing Antimicrobial Glass - An antimicrobial glass is provided which can release a predetermined amount of silver ion rapidly for a long period of time and can provide a predetermined antimicrobial treatment repeatedly to a matter to be antibacterialized during or after washing and which is excellent in discoloration prevention effect and discriminativity, and a method for producing the same is also provided. | 2010-01-07 |
20100004112 | OPTICAL GLASS - An object of the present invention is to provide an optical glass having optical constants of a refractive index of 1.70 to 1.89 and an Abbe number of 20 to 30 and being excellent in chemical durability. The invention relates to an optical glass containing P | 2010-01-07 |
20100004113 | SYNTHETIC SILICA HAVING LOW POLARIZATION-INDUCED BIREFRINGENCE, METHOD OF MAKING SAME AND LITHOGRAPHIC DEVICE COMPRISING SAME - Disclosed are synthetic silica glass having a low polarization-induced birefringence, process for making the glass and lithography system comprising optical element made of the glass. The silica glass has a polarization-induced birefringence measured at 633 nm of less than about 0.1 nm/cm when subjected to excimer laser pulses at about 193 nm having a fluence of about 40 μJ·cm | 2010-01-07 |
20100004114 | FIRED REFRACTORY CERAMIC PRODUCT - The invention relates to a fired refractory ceramic product. According to the invention, this generic term encompasses both shaped and unshaped products. Shaped products are ones which have a defined shape so that they can be manufactured in finished form on the premises of the manufacturer. Shaped products include: bricks, nozzles, tubes, stoppers, plates, etc. The term unshaped products includes ones which are usually produced by the user from a corresponding composition. They include bases for furnaces which are cast from a composition but also repair compositions, etc. | 2010-01-07 |
20100004115 | Sliding Member, Manufacturing Method Thereof, Mechanical Seal Ring Using Sliding Member and Mechanical Seal Using Mechanical Seal Ring - A sliding member having a sliding surface comprising a silicon carbide sintered body having a primary phase comprising mainly silicon carbide, and a subphase having a different composition from the primary phase and containing at least boron, silicon and carbon. The ratio of pores having a roundness of 6 μm or less and a pore diameter of 10 to 60 μm with respect to all pores having a pore diameter of 10 μm or more in the sliding surface is 60% or more. This enables retention of good seal properties even in a long-term continuous use. The subphase in the silicon carbide sintered body is preferably granular crystal phases dotted among a plurality of the primary phases. This provides excellent lubricating liquid holding performance as well as excellent thermal conductivity and excellent thermal shock resistance properties. | 2010-01-07 |
20100004116 | WATER-BASED RARE EARTH METAL COMPOUND SOL, MANUFACTURING METHOD THEREOF, AND METHOD FOR MANUFACTURING CERAMIC POWDER USING THE SAME - A particulate subcomponent for a barium titanate dielectric is obtained from a sol in which a rare earth metal compound is dispersed in water. The rare earth metal compound includes a carboxylic acid having at least three carbonyl groups and at least one rare earth metal which can be Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu so that the molar ratio (carbonyl group/rare earth metal) is in the range of 1.2 to 3. A method of making the sol and a method of using the sol to make a ceramic powder is described. | 2010-01-07 |
20100004117 | METAL OXIDE CATALYST CARRIER PARTICLE AND EXHAUST GAS PURIFICATION CATALYST - A metal oxide catalyst carrier particle has a center portion and an outer skin portion each containing a first metal oxide and a second metal oxide. The center portion and the outer skin portion are different in composition. The mole fraction of the metal of the first metal oxide is higher in the center portion than in the outer skin portion and the mole fraction of the metal of the second metal oxide is higher in the outer skin portion than in the center portion. The second metal oxide is selected from the group consisting of rare earth oxides, except for ceria, and alkali earth metal oxides. In addition, platinum is supported on the metal oxide catalyst carrier particle, thus forming an exhaust gas purification catalyst. | 2010-01-07 |
20100004118 | Process for Starting up a Fluidized Catalytic Reaction Apparatus Used for Producing Lower Olefins - Disclosed is a process for starting up fluidized reaction apparatus which are used for producing lower olefins from methanol or/and dimethyl ether. Said process includes after heating the catalyst bed of circulating fluidized catalytic reaction apparatus to above 200° C. or 300° C. by using a starting-up auxiliary heat source, feeding methanol or dimethyl ether raw materials to a reactor, whereby heat released by the reaction makes the temperature of the reaction system apparatus increase quickly to a designed temperature, consequently making the system reach the normal operation state rapidly. Said process is suitable for starting up an exothermic fluidized catalytic reaction apparatus and can simplify the apparatus and operation, accordingly lowering the cost. | 2010-01-07 |
20100004119 | Sorbent Comprising Activated Carbon Particles, Sulfur And Metal Catalyst - Sorbents comprising activated carbon particles, sulfur, and metal catalyst. The sorbents may be used, for example, for the removal of a contaminant, such as mercury, from a fluid stream. | 2010-01-07 |
20100004120 | PLATINUM BASED CATALYST FOR OXIDATION/REDUCTION REACTION AND ITS USE - Disclosed herein are a platinum-based catalyst for oxidation/reduction reactions and the use thereof. The platinum-based catalyst is prepared by loading a catalyst composition comprising a water soluble salt of at least one metal selected from among cerium (Ce), zirconium (Zr) and rhenium (Re), on a support comprising at least one selected from among alumina, silica and titania. The disclosed catalyst can be prepared in a simple manner without any particular limitation as to the kind of usable water soluble platinum salt, and when it is applied to various oxidation reactions, including water gas shift reactions of carbon monoxide, three-way catalytic reactions, and selective oxidation reactions of carbon monoxide, and to reduction reactions, such as reactions of removing nitrogen oxide (NOx), it will show excellent catalytic activity. In particular, the disclosed catalyst shows excellent performance even in a specific temperature range in which it is difficult to apply the prior high-temperature water gas shift reaction catalyst and low-temperature water gas shift reaction catalyst. Also, it can remove carbon monoxide even at high temperatures without the loss of hydrogen caused by methanataion, and thus is particularly useful in a hydrogen production process of producing high-purity hydrogen for fuel cells. | 2010-01-07 |
20100004121 | Short carbon nanotube for catalyst support, method of preparing the same, catalyst impregnated carbon nanotube using the same, and fuel cell using the catalyst impregnated carbon nanotube - The present invention is related to a short carbon nanotube for a catalyst support. In particular, the short carbon nanotube may be opened at both ends, a length of less than about 300 nm, and an aspect ratio in the range of about 1 to about 15. The short carbon nanotube has a broad surface area and better electric conductivity and is opened at both ends, thereby impregnating a metallic catalyst into the inner side of the carbon nanotube. Also, a catalyst impregnated carbon nanotube has a broad effective specific surface area, and thus, has an improved efficiency of catalyst utilization, can reduce an amount of the catalyst used and can efficiently diffuse a fuel. Accordingly, when catalyst impregnated carbon nanotube is used in a fuel cell, etc., improvements can be made in the pricing, power density of an electrode, and energy density of a fuel cell. | 2010-01-07 |
20100004122 | Exhaust Gas-Purifying Catalyst | 2010-01-07 |
20100004123 | OXYGEN STORAGE MATERIAL - An excellent oxygen storage capacity is achieved even in the case used for a long period of time under high temperature conditions. An oxygen storage material contains a first particle made of a composite oxide of cerium and zirconium or a composite oxide of cerium, a rare-earth element other than cerium and zirconium, a second particle including a composite oxide of a rare-earth element, an alkaline-earth element and zirconium, and a precious metal. A part of the precious metal forms a solid solution with the composite oxide included in the second particle. | 2010-01-07 |
20100004124 | Systems and methods for delivery of materials for agriculture and aquaculture - Systems and methods for delivering agricultural (including aquacultural) materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the agricultural materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable. | 2010-01-07 |
20100004125 | Pesticidal Mixtures - Pesticidal mixtures, comprising a) clothianidine of formula (I) and b) triticonazole of formula (II), in synergistically effective amounts, plant-protecting mixtures, compositions containing the mixtures, and to methods for controlling or preventing fungal infestation or harmful insects or nematodes in plants, and methods of improving the health of plants by applying said mixtures to the plants or the locus thereof. | 2010-01-07 |
20100004126 | SOIL CONDITIONER FOR LAWN EARTH AND METHOD OF MANAGING LAWNGRASS GROWTH USING THE SOIL CONDITIONER - Provided is a soil conditioner for providing conditions suitable for growth of turf in lawn-growing soil constituting the surface layer of developed land for a lawn-covered athletic field, and for maintaining the conditions over a long period of time. The soil conditioner is characterized by containing a carbonized substance which has a percent carbonization of at least 90%, which has a porous, amorphous structure including numerous pores, and which has substantially no hydroxyl group, wherein the pores contain micropores having a pore size of 0.1 μm or less in an amount of at least 25%, and the micropores are in communication with one another. The soil conditioner is employed in the form of powder or particles in a mode in which the soil conditioner is mixed with lawn-growing soil, a mode in which the soil conditioner is spread on the surface layer of lawn, or a mode in which the soil conditioner is charged into numerous holes provided in lawn. | 2010-01-07 |
20100004127 | 3'-ALKOXYSPIROCYCLOPENTYL-SUBSTITUTED TETRAMIC AND TETRONIC ACIDS - The invention relates to novel compounds of the formula (I) | 2010-01-07 |
20100004128 | HERBICIDAL ISOXAZOLINE COMPOUNDS - Novel compounds of formula (I): wherein R | 2010-01-07 |
20100004129 | HERBICIDALLY ACTIVE 4-(3-ALKYLSULFINYLBENZOYL)PYRAZOLES - 4-(3-Alkylsulfinylbenzoyl)pyrazoles of the formula (I) are described as herbicides. | 2010-01-07 |
20100004130 | PROCESS FOR PREPARING SUBSTITUTED 2-ALKOXYCARBONYL-3-AMINOTHIOPHENES - The present invention relates to a process for preparing 4-alkoxycarbonyl-3-aminothiophenes of the general formula (I) | 2010-01-07 |
20100004131 | SOLID FORMULATIONS OF HYDROGEN CYANAMIDE FOR AGRICULTURAL APPLICATIONS - Agricultural crops are protected from the growth of weeds and other undesirable organisms by the application of hydrogen cyanamide in a granular formulation. | 2010-01-07 |
20100004132 | MODIFIED INORGANINC MATERIALS - A method of conditioning a tubular clay material to enable its loading with an active, the method comprising the step of exposing the tubular clay material to a chemical agent in a manner such that the agent sorbs to a surface of the clay material that is internal of the tube, the chemical agent being selected such that, when the agent is sorbed to the clay material internal surface, the affinity of the tubular clay material for the active is altered. | 2010-01-07 |
20100004133 | Fluorinated Precursors of Superconducting Ceramics, and Methods of Making the Same - This invention provides a method of making a fluorinated precursor of a superconducting ceramic. The method comprises providing a solution comprising a rare earth salt, an alkaline earth metal salt and a copper salt; spraying the solution onto a substrate to provide a film-covered substrate; and heating the film-covered substrate in an atmosphere containing fluorinated gas to provide the fluorinated precursor. | 2010-01-07 |
20100004134 | Combinatorial libraries of conformationally constrained polypeptide sequences - The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses. | 2010-01-07 |
20100004135 | Methods, Systems, and Software for Identifying Functional Bio-Molecules - The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods. | 2010-01-07 |
20100004136 | Methods, Systems, and Software for Identifying Functional Bio-Molecules - The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods. | 2010-01-07 |
20100004137 | Characterization of biochips containing self-assembled monolayers - The present invention relates to a method of characterizing biochips with matrix-assisted laser desorption/ionization and time of flight mass spectrometry (MALDI-TOF MS). | 2010-01-07 |
20100004138 | Reagent for detecting biopolymer and method for detecting biopolymer - Detects the presence of binding between a sample biopolymer and a probe biopolymer and the amount of binding, without modifying the sample biopolymer in any way. The present invention provides a reagent for biopolymer detection comprising semiconductor nanoparticles on which a functional group having a positive or negative charge is exposed, and a method for biopolymer detection which detects the presence of binding between a sample biopolymer and a probe biopolymer and the amount of binding by electrostatically binding a semiconductor nanoparticle on which a functional group having a positive or negative charge is exposed to a negative or positive charge of the sample biopolymer. | 2010-01-07 |
20100004139 | CONSTRUCTS AND LIBRARIES COMPRISING ANTIBODY SURROGATE LIGHT CHAIN SEQUENCES - The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same. | 2010-01-07 |
20100004140 | METHOD OF PROGNOSIS - Provided are methods, kits and arrays for use in determining susceptibility to keloid formation. These determine susceptibility based on comparison of gene expression in a patient of interest with expression in a control sample. If expression of at least one gene, selected from the group of genes set out in Table 1, is increased in a sample representative of gene expression in the patient compared to expression of the same gene (or genes) in the control sample this is indicative of a susceptibility to keloid formation. | 2010-01-07 |
20100004141 | siRNA targeting polo-like Kinase-1 (PLK-1) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to PLK-1. | 2010-01-07 |
20100004142 | siRNA targeting myeloid cell Leukemia sequence 1 - Efficient sequence specific gene silencing of myeloid cell leukemia sequence 1 is possible through the use of siRNA technology. By selecting particular siRNAs directed to myeloid cell leukemia sequence 1 by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. | 2010-01-07 |
20100004143 | PROBE-ARRAY SUBSTRATE, PROBE ARRAY, AND METHOD OF PRODUCING THE SAME - A probe-array substrate includes a plurality of probe holding units each having a projection that exhibits a hydrophilicity and a hydrophobic region disposed so as to surround each of the probe holding units. The probe-array substrate can further include an inspection region for use in checking whether mixture of probe solutions is present among the plurality of probe holding units. The inspection region is disposed between the neighboring probe holding units across the hydrophobic region. | 2010-01-07 |
20100004144 | SURFACE ACTIVATED BIOCHIP - The present invention provides substrates having a plurality of micro-locations on its surface. Each micro-location has an effective dose of an ion beam treatment such that the plurality of the micro-locations exhibit an affinity to a compound that is different from the affinity of the remainder of the substrate surface to that compound. The substrates of the invention can be utilized to form microarrays of biological molecules, such as oligonucleotides or peptides. Such microarrays can find a variety of applications. For example, they can be employed in large scale hybridization assays in many genetic applications, such as mapping of genomes, monitoring of gene expression, DNA sequencing, genetic diagnosis, and genotyping of organisms. | 2010-01-07 |
20100004145 | FLUID LOSS PILLS - A fluid loss pill that includes a crosslinked polymer gel, a brine, and solid salt particles disposed in said gel is described. Further, a method for reducing fluid loss that includes pumping a selected amount of a fluid loss pill into a wellbore leading to an oil-condensate-, or gas-producing formation, the fluid loss pill including a crosslinked polymer gel, a brine, and solid salt particles disposed in said gel is described. | 2010-01-07 |
20100004146 | Leak-Off Control Agent - A method of controlling leak-off and reducing the concentration of polymers (and/or other materials) in filter cakes formed when oilfield treatment fluids flow through subterranean formation faces involves adding large plate-like degradable and/or non-degradable, particles to polymer or VES-viscosified oilfield treatment fluids, at concentrations of such particles that are less than that required to cover the contacted formation face with a monolayer of such particles. When these large plate-like degradable and/or non-degradable particles are included in the fluid, polymer concentrates to form filter cake only in regions on the formation face (for example fracture faces) not shielded by the large plate-like particles, and the remaining formation face is not covered by concentrated polymer. As a result, the damage due to concentration of polymer and/or other materials in the filter cake during leak-off is reduced, and subsequent clean-up of the filter cake is easier. | 2010-01-07 |
20100004147 | CAPPED PARTICLES FOR USE IN LUBRICANTS - The present invention relates to additives for use in lubricant compositions to processes for producing the additives, and to the use of the additives in lubricants and in systems that are lubricated. More specifically, the additive includes a capped particle comprising: (i) one or more core particles wherein the core particle is an inorganic particle having a dimension less than about 5 μm; and (ii) one or more multi-block copolymers attached to the inorganic particles, wherein the multi-block copolymer comprises a) at least one nonpolar polymer block; b) at least one first polar polymer block; and c) at least one second polar polymer block; wherein the nonpolar polymer block is interposed between the first polar polymer block and the second polar polymer block, the first polar polymer block is attached to the core particle, and at least a portion of the second polar polymer block is not attached to the core particle. When used in a lubricant to lubricate a metallic surface of a workpiece, the capped particle preferably adhere to the metallic surface of the workpiece. | 2010-01-07 |
20100004148 | LOW SULFUR, LOW SULFATED ASH, LOW PHOSPHORUS AND HIGHLY PARAFFINIC LUBRICANT COMPOSITION - The present invention relates to a lubricant composition having a sulphur content of from 0.01 to 0.3 wt. %, a phosphorus content of from 0.01 to 0.1 wt. % and a sulphated ash content of from 0.1 to 1.2 wt. %, based on the total weight of the lubricant composition, which comprises a base oil or base oil blend, wherein the lubricant composition has a kinematic viscosity at 100° C. of more than 5.0 mm | 2010-01-07 |
20100004149 | Crosslinked Polymer - The present invention provides a lubricating composition comprising: (a) an oil of lubricating viscosity; and (b) a crosslinked polymer derived from monomers comprising: (i) 0.001 wt % to 7 wt % of a di- or higher functional crosslinking monomer; (ii) 30 wt % or higher of a hydrocarbyl-substituted (meth)acrylic monomer, wherein each hydrocarbyl contains greater than 8 carbon atoms; and (iii) 0 wt % to 40 wt % of a hydrocarbyl-substituted (meth)acrylic monomer, wherein each hydrocarbyl contains 8 or fewer carbon atoms. The invention further provides a method of preparing the crosslinked polymer and its use in a lubricating composition for lubricating an internal combustion engine. | 2010-01-07 |
20100004150 | ALUMINUM CHELATES - Provided are aluminum chelates having the formula (I). Also provided are compositions having these chelates, methods of producing these chelates, and methods of modifying the viscosity of a liquid or a semisolid using these chelates. | 2010-01-07 |
20100004151 | Lubricating Compositions - The invention provides a lubricating composition containing hydrocarbyl-capped polyoxyalkylene polyol. The invention further provides lubricating compositions containing the hydrocarbyl-capped polyoxyalkylene polyol; and a method for lubricating a mechanical device with the lubricating composition. | 2010-01-07 |
20100004152 | Synthetic Microgel Polymer Compositions for Treating and/or Modifying Hard Surfaces - Synthetic microgel polymer compositions are useful for treating and/or modifying hard surfaces, in particular by promoting the hydrophilization thereof, notably in cleaning or rinsing operations. | 2010-01-07 |
20100004153 | Cleaning Compositions and Methods of Using Same - The invention is generally related to cleaning compositions and methods of using same. More particularly, the invention is related to cleaning compositions which are substantially free of volatile organic chemicals. | 2010-01-07 |
20100004154 | THERMALLY SENSITIVE POLYMERIC DYE TRANSFER INHIBITOR - The invention relates to the use of thermally sensitive polymers as dye transfer inhibitors. The invention also relates to novel thermally sensitive polymers suitable as dye transfer inhibitors, and to washing compositions which comprise these polymers. | 2010-01-07 |
20100004155 | Azeotrope or Azeotrope-Like Composition Comprising 1,1,2,2-tetrafluoro-1-methoxyethane - There is provided an azeotrope or azeotrope-like composition containing (A) 1,1,2,2-tetrafluoro-1-methoxyethane and (B) a compound formed of at least one selected from the group consisting of (Z)-1-chloro-3,3,3-trifluoropropene, 2-bromo-3,3,3-trifluoropropene, and (E)-2-bromo-1,3,3,3-tetrafluoropropene. | 2010-01-07 |
20100004156 | Small Compounds That Correct Protein Misfolding and Uses Thereof - The invention features compositions and methods that are useful for treating or preventing a protein conformation disease in a subject by correcting misfolded proteins in vivo. In addition, the invention provides compositions and methods that are useful for expressing a recombinant protein in a biochemically functional conformation. | 2010-01-07 |
20100004157 | PHARMACEUTICAL COMPOSITIONS FOR THE ORAL OR RECTAL ADMINISTRATION OF PROTEIN SUBSTANCES - Pharmaceutical compositions with differentiated, controlled and/or site-specific release are claimed for the oral or rectal administration of peptide or protein substances, including antibodies and soluble receptors capable of antagonising the pathogenetic role of several cell mediators such as interleukines, chemokines, growth factors, tissue necrosis factors, and interferons. Through the incorporation of the peptide or protein substance inside a controlled and/or site-specific release preparation, the application of this invention permits transporting the substances directly into the intestinal environment where a reduced quantity of proteolytic enzymes is present, a less aggressive microenvironment for the integrity of the protein structure and sequence. | 2010-01-07 |
20100004158 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE - Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. (I) | 2010-01-07 |
20100004159 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES - The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives. | 2010-01-07 |
20100004160 | SUBSTITUTED FUSED HETEROCYCLIC C-GLYCOSIDES - This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X. | 2010-01-07 |
20100004161 | Toll Like Receptor 4 Dysfunction and the Biological Applications Thereof - The present invention relates to an in vitro method of assessing the sensitivity of a subject to a treatment of cancer, which method comprises detecting the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from the subject, the presence of said mutated TLR4 nucleic acid or abnormal TLR4 expression or activity being indicative of a resistance to said treatment. The invention further provides compounds for treating or preventing a cancer in a subject having a mutated TLR4 nucleic acid or an abnormal TLR4 protein expression or activity. | 2010-01-07 |
20100004162 | Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses thereof - The present invention provides a novel family of polypeptides which are ligand-gated channel receptor accessory molecules or ligands, denoted Lynx. This invention provides an isolated polypeptide comprising an amino acid sequence of a Lynx polypeptide in which the amino acid sequence is set forth in SEQ ID NO:2, SEQ ID NO:4 or SEQ ID NO:15, including fragments, mutants, variants, analogs, homologs, or derivatives, thereof. This invention further provides an isolated immunogenic polypeptide comprising an amino acid sequence of a Lynx polypeptide and relates to antibodies of Lynx polypeptides and the use of such antibodies. The invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a Lynx polypeptide. This invention provides pharmaceutical compositions and diagnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids of the present invention. Assays for compounds which mimic, alter or inactivate the polypeptides of the present invention for use in therapy are also provided. The present invention further relates to methods of isolating Lynx polypeptides and the nucleic acids encoding such polypeptides. | 2010-01-07 |
20100004163 | Composition and Uses of a Galectin for Treatment of Dry Eye Syndrome - Methods for the therapeutic treatment of dry eye in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-1 protein, a galectin-3, a galectin-7 protein and/or a galectin-8 protein are provided. Pharmaceutical and ophthalmic compositions and kits, comprising a pharmaceutically an active agent which is a galectin-1 protein, a galectin-3 protein, galectin-7 protein and/or a galectin-8 protein, and a suitable carrier or a diluent, are provided. | 2010-01-07 |
20100004164 | PLATELET AGGREGATION INHIBITOR COMPOSITION - The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d):
| 2010-01-07 |
20100004165 | Novel Protein Transduction Domains and Uses Therefor - The present invention provides novel transduction domains, compositions comprising such transduction domains, and their use for in vivo molecular delivery. | 2010-01-07 |
20100004166 | Endothelin and Endothelin Receptor Agonists in the Treatment of Metabolic Diseases - Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an endothelin or an endothelin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. Pharmaceutical compositions for use in the methods of the invention are also disclosed. | 2010-01-07 |
20100004167 | CSF3R POLYPEPTIDES AND USES THEREOF - The present invention relates to CSF3R polypeptide variants and their uses, particularly for therapeutic or prophylactic treatment in human subjects. The invention also relates to nucleic acids encoding said polypeptides, vectors comprising such nucleic acids and recombinant cells containing the same. The invention further discloses methods of producing such polypeptides, as well as methods and tools for detecting or dosing these polypeptides in any sample. | 2010-01-07 |
20100004168 | Use of Crystallin For The Modulation of Angiogenesis - The present invention features therapeutic and prophylactic compositions and methods for modulating a blood vessel by altering angiogenesis, vasculogenesis, blood vessel stabilization, regression, persistence, or remodeling. | 2010-01-07 |
20100004169 | CCN3 peptide - The present application relates to nucleic acid and peptide sequences of CCN3 and derivatives and fragments thereof useful in the treatment of disease, in particular tumours and/or for use as a clinical marker. | 2010-01-07 |
20100004170 | PROTEIN-CONTAINING SUBSTANCE WITH INCREASED THERMAL STABILITY - The invention relates to an agent with increased thermal stability comprising a core and a coating layer characterized in that the core comprises at least one biologically active protein and that the coating layer comprises a micronized product from leguminous plants, a method for the production of this agent as well as the use of a micronized product from leguminous plants to increase the thermal stability of biologically active proteins in methods for the production of a granulated product as well as in methods for the production of animal feed, food and pharmaceuticals. | 2010-01-07 |
20100004171 | Therapeutic Methods for Neuropathic Pain - The agrin protein was shown to be important in preventing the development of neuropathic pain, as well as in treating neuropathic pain. Both agrin protein and gene expression were shown to be down-regulated in mammals with neuropathic pain. Increasing either agrin gene expression or protein resulted in a decrease in the development of neuropathic pain. Agrin protein or the C-terminal agrin fragments can be administered in a number of ways, preferably by intrathecal injection. In addition, agrin can be increased by administering a compound shown to affect agrin gene expression or agrin protein concentration, e.g., SCP-I and SCP-M1 (also known as JMM). Agrin protein decrease was shown to be prevented by administering an NMDA receptor antagonist, e.g., MK801. Agrin and a C-terminal agrin fragment also induced phosphorylation of the NMDA receptor subunit NR1 at the serine residue site which led to suppression of neuropathic pain. | 2010-01-07 |
20100004172 | Compositions for mucosal and oral administration comprising hcg fragments - The invention relates to the field of immunology, more specifically to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease and other inflammatory diseases. The invention in particular relates to the systemic treatment of inflammatory disease by oral or mucosal administration of a pharmaceutical composition with a gene-regulatory peptide. The invention provides a pharmaceutical composition in a form for mucosal application for the treatment of a subject suffering from disease, the pharmaceutical composition comprising a pharmacologically effective amount of a gene-regulatory peptide or a functional analogue thereof together with a pharmaceutically acceptable diluent. | 2010-01-07 |
20100004173 | RECONSTITUTED SURFACTANTS HAVING IMPROVED PROPERTIES - Reconstituted surfactants comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B are useful for the treatment and/or prophylaxis of RDS and other respiratory disorders. | 2010-01-07 |
20100004174 | USE OF THYMOSIN ALPHA 1 FOR THE PREPARATION OF A MEDICAMENT FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES - The invention concerns the use of thymosin alpha 1 for the preparation of a medicament for the prevention and treatment of autoimmune diseases such as multiple sclerosis, and inflammatory bowel diseases such as Crohn's disease or ulcerative colitis. | 2010-01-07 |
20100004175 | NOVEL BMP-12-RELATED PROTEINS AND METHODS OF THEIR MANUFACTURE - The invention provides novel BMP-12-related proteins, including methods of their manufacture. The proteins include substituted, truncated and substituted-truncated BMP-12-related proteins. The substituted BMP-12-related proteins contain a substitution at one or more oxidation-sensitive methionine residues with non-methionine residues, such as norleucine. The substituted BMP-12-related proteins exhibit normal bioactivity and enhanced resistance to oxidation, relative to the unsubstituted protein. The truncated BMP-12-related proteins exhibit enhanced activity. | 2010-01-07 |
20100004176 | AXMI-115, AXMI-113, AXMI-005, AXMI-163 AND AXMI-184: INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE - Compositions and methods for conferring insecticidal activity to host cells are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in host cells. Compositions also comprise transformed host cells. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 6, 13, or 14, or the nucleotide sequence set forth in SEQ ID NO:1, 2, 3, 11, or 12, as well as variants and fragments thereof. | 2010-01-07 |
20100004177 | TOXIN COMPLEX PROTEINS AND GENES FROM XENORHABDUS BOVIENII - The subject invention relates to novel | 2010-01-07 |
20100004178 | Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction - A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed. | 2010-01-07 |
20100004179 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 2010-01-07 |
20100004180 | Agents for the Detection and Modulation of B-Cells and Antibodies - The present invention relates to the identification and use of peptide and peptide analogs that represent epitopes for naturally-occurring antibodies (Nabs). These epitopes may be used to monitor the degree of autoimmunity in an organism, as well as to modulate the activity of B-cells producing Nabs. | 2010-01-07 |
20100004181 | COMBINATION COMPRISING N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-(4-(1,3,4-OXADIAZOL-2-YL)PHENYL) PYRIDINE-3-SULPHONAMIDE AND AN LHRH ANALOGUE AND/OR A BISPHOSPHONATE - A combination, comprising N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide, or a pharmaceutically acceptable salt thereof, and an LHRH analogue and/or a bisphosphonate is described. | 2010-01-07 |
20100004182 | COMPOSITION EFFECTIVE TO PREVENT OR TREAT ADULT DISEASE - Disclosed is a composition comprising, as an active ingredient, an enzyme digest that is produced by digesting a basic fraction of an animal-derived cartilage extract with an enzyme. Also disclosed is a polypeptide composition comprising, as an active ingredient, at least one polypeptide selected from specific polypeptides including a polypeptide comprising an amino acid sequence depicted in any one of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10. | 2010-01-07 |
20100004183 | MINERAL COLLAGEN CHELATES AND METHODS OF MAKING AND USING SAME - Collagen peptide chelated mineral products, pharmaceutical formulations thereof and methods for preparing same are provided. Also provided is a method for generating the optimal size of collagen peptide for optimum mineral chelation as well as optimum biological function for supporting bone health and joint health. Also disclosed are methods of increasing bone density/preventing osteoporosis, of reducing joint pain and/or joint deterioration from osteoarthritis, degenerative joint disease, joint defect, and rheumatoid arthritis. | 2010-01-07 |
20100004184 | Anti-hypercholesterolemic compounds - This invention provides cholesterol absorption inhibitors of Formula (I), and the pharmaceutically acceptable salts and esters thereof. The compounds arc useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events. | 2010-01-07 |
20100004185 | EXTRACTS DERIVED FROM SUGAR CANE AND A PROCESS FOR THEIR MANUFACTURE - An extract derived from sugar cane having GI or burn rate reducing characteristics wherein the extract comprises a mixture of one or more polyphenols, one or more carbohydrates, one or more minerals and one or more organic acids. | 2010-01-07 |
20100004186 | Antithrombotic Dual Inhibitors Comprising A Biotin Residue - The present invention relates compounds of the formula (I) oligosaccharide-spacer-A (1), wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising two to twenty five monosaccharide units, the charge being compensated by positively charged counterions, and wherein the oligosaccharide residue is derived from an oligosaccharide which has (AT-III mediated) anti-Xa activity per se; the spacer is an essentially pharmacologically inactive flexible linking residue having a chain length of 10 to 70 atoms; A is the residue —CH[NH—SO | 2010-01-07 |
20100004187 | COBALT-AMINE BASED METAL COMPLEX AS AN ANTIBACTERIAL COMPOUND - Disclosed herein is a method of: administering to a subject suspected of being infected with a bacterium, a composition of a cobalt (III) compound having the formula CoR | 2010-01-07 |
20100004188 | SUBSTITUTED BENZIMIDAZOLE-, BENZTRIAZOLE-, AND BENZIMIDAZOLONE-O-GLUCOSIDES - This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X. | 2010-01-07 |
20100004189 | COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS - Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating cystic fibrosis or a symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered fluids optionally in combination with other therapeutic agents (e.g., antibiotics, albuterol, budesonide, etc.). Particular embodiments comprise use and/or synergy with tobramycin for treating bacterial infection, and use and/or synergy with a bronchiodilator. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (like, membrane receptors, including but not limited to G protein coupled receptors, and intercellular junctions). | 2010-01-07 |
20100004190 | BLOCKING THE MIGRATION OR METASTASIS OF CANCER CELLS BY AFFECTING ADHESION PROTEINS AND THE USES OF NEW COMPOUNDS THEREOF - This invention provides methods, processes, compounds and compositions for modulating the gene expression and modulating the secretion, expression, or synthesis of adhesion proteins or their receptors to cure disease, wherein the modulating comprises positive and negative regulating; wherein comprises inhibiting cancer growth, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, Myosin, vitronectin, collagen, laminin, Glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the methods, processes, compounds and compositions are also for anti-angiogenesis; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer. | 2010-01-07 |
20100004191 | Compositions of S-adenosyl-L-methionine. - Compositions of S-adenosyl-L-methionine with indole-3-propionic acid and methods to treat conditions associated with DNA hypomethylation are disclosed. | 2010-01-07 |
20100004192 | 4'-Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication - The present invention relates to the use of nucleoside derivatives of formula Ia | 2010-01-07 |
20100004193 | COMBINATION THERAPY - A method of treating a subject affected by neoplastic diseases includes the administration to the subject of an aminoglycoside antibiotic in combination with a nucleoside analogue. | 2010-01-07 |
20100004194 | USE OF ISOMALTULOSE IN FOOD PRODUCTS HAVING A REGENERATIVE EFFECT - The invention relates to the use of isomaltulose or mixtures of isomaltulose for the production of functional food products for improving the regeneration of individuals exposed to physical exertion. | 2010-01-07 |
20100004195 | Decoy Influenza Therapies - The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys. | 2010-01-07 |
20100004196 | HEPARAN SULFATE PROTEOGLYCAN COMPOSITION AND USE THEREOF - The present invention relates to method for the preparation of glycosaminoglycan compositions, isolated glycosaminoglycan compositions obtainable therefrom, glycosaminoglycan compositions, kits and use thereof. More specifically, the present invention provides a method for isolating glycosaminoglycan compositions of the invention from human follicular fluid. The compositions, related methods and uses according to the present invention are useful in the treatment and/or prevention of thrombotic diseases, cell proliferation disorders, proteolysis and inflammation mediated cell invasion and infertility. | 2010-01-07 |
20100004197 | PROCEDURE FOR THE PREPARATION OF GLYOXALATED CATIONIC GUAR - Procedure for the preparation of cationic guar having DS comprised between 0.01 and 3, soluble at basic pH and suitable for the use in the cosmetic field and in household cleaning products comprising the following steps: a) 100 parts by weight of guar flour are reacted with 3-chloro-2-hydroxypropyl trimethylammonium chloride and sodium hydroxide, in from 5 to 500 parts of a water and alcohol mixture containing from 20 to 50% by weight of water; b) the mixture is acidified to a pH between 4 and 6; c) from 2.2 to 3 parts by weight of glyoxal are added, and the reaction is stirred for approximately 30 minutes; d) from 300 to 1200 parts by weight of ambient temperature water are added and mixed for 10 to 90 minutes; e) the mixture is filtered under vacuum and the product dried to obtain glyoxalated purified cationic guar. | 2010-01-07 |
20100004198 | POLYSACCHARIDE GEL FORMULATION HAVING INCREASED LONGEVITY - Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications. | 2010-01-07 |
20100004199 | GLYCINE BETAINE AND ITS USE - The present invention provides pharmaceutical uses of betaines, and especially glycine betaine, such as for the treatment of thromboses not induced by hyperhomocystenemia or homocystinuria, of blood disorders, such as blood coagulation and thrombi formation. | 2010-01-07 |
20100004200 | MELOXICAM AND GLUCOSAMINE FORMULATION AND USES THEREOF - Provided herein is a process for making compositions and methods of using such compositions to treat pain, inflammation and/or inflammatory disease or disorder including degenerative osteoarticular disease. | 2010-01-07 |
20100004201 | Cosmetic - The present invention provides a cosmetic that contains glycerin modified on both ends with silicone represented by the following general formula (a). | 2010-01-07 |
20100004202 | Quaternary ammonium-functionalized-POSS compounds - A silsesquioxane cage structure has a general formula [R | 2010-01-07 |
20100004203 | MEDICAMENT FOR PREVENTIVE AND/OR THERAPEUTIC TREATMENT OF BOWEL DISEASE - A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. | 2010-01-07 |
20100004204 | ROS-SENSITIVE IRON CHELATORS AND METHODS OF USING THE SAME - The present invention provides compounds of Formula (I): along with compositions containing the same and methods of use thereof in treating oxidative stress. | 2010-01-07 |
20100004205 | PHARMACEUTICAL COMPOSITIONS - Synergistic combinations of a squalene epoxidase inhibitor and a leucyl-tRNA synthetase inhibitor are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin or nail plays a role, such as atopic dermatitis, acne vulgaris, seborrhoeic dermatitis, rosacea or onychomycosis, and in situations of fungal resistance. | 2010-01-07 |
20100004206 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION - The present invention provides a benzoazepine compound represented by following general formula (1): | 2010-01-07 |
20100004207 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation. | 2010-01-07 |
20100004208 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS - The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors. | 2010-01-07 |