01st week of 2012 patent applcation highlights part 37 |
Patent application number | Title | Published |
20120003601 | Jet Injector Use In Oral Evaluation - A tooth treatment device includes a detector that detects a marker of oral health and a fluid ejector that ejects fluid against teeth in response to the detected marker. The device can include a housing configured to be held on hand, the fluid ejector being positioned at an end of the housing. The fluid may include a liquid, a medicant, a cleansing solution, cleaning particles, or any combination thereof. The medicant can include any combination of a chelating agent, fluoride, a fluorescent dye, a bacterial specific probe, and a biochemical specific biomarker. Further, the device can include a servo controller controlling pressure of ejected fluid in response to the detected marker and a sensed surface condition, latter including for example, a mechanical property of tissue. The device may include a pressure sensor that senses pressure of the fluid in the ejector. Also included may be a distance sensor that senses distance of the ejector from a tissue surface. The surface condition may be sensed using the sensed pressure, sensed distance, or any combination thereof. In some embodiments, the fluid ejector comprises a stationary magnet assembly providing a magnetic field and a coil assembly, slidably disposed with respect to the magnet assembly, the coil assembly driving ejection of the fluid jet. A method of tooth treatment includes detecting a marker of oral health and controlling ejection of a fluid jet against the tooth responsive to the detected marker. In some embodiments, detecting the marker includes detecting plaque and the ejection is controlled to clean the plaque. Detecting the marker can include collecting a sample from an oral cavity. | 2012-01-05 |
20120003602 | DEVICE FOR OBSERVATION OF THE ORAL CAVITY - A device for observation of the oral cavity having a mirror arrangement with at least one mirror element assigned to a certain observation zone in the oral cavity area and a positioning structure for positioning the mirror arrangement in the oral cavity in a reproducible manner. | 2012-01-05 |
20120003603 | Air Water Vacuum Syringe and Method of Use - An air water vacuum dental instrument includes a handle; a head; an air control carried by at least one of the handle and the head; a water control carried by at least one of the handle and the head; a vacuum control carried by at least one of the handle and the head; and an air water vacuum tip coupled to the head and configured to provide at least air, water, and vacuum in a mouth of a dental patient at the air water vacuum tip. | 2012-01-05 |
20120003604 | OCCLUSAL ADJUSTMENT SYSTEM - Occlusal-surface shape data and occlusal-surface position data of dentures are acquired on a dentist side, and the data is then transmitted to a grinding data provider side. A maxillomandibular occlusal state data is reproduced from the occlusal-surface shape data and the occlusal-surface position data on the grinding data provider side. A maxillomandibular occlusal adjustment portion is determined by changing a maxillomandibular occlusal vertical dimension by the grinding data provider side. Cutting data including the occlusal adjustment portion data and the occlusal-surface position data are prepared on the grinding data provider side, and the data is transmitted to the dentist side. An occlusal adjustment is carried out by cutting the dentures by a grinding machine based on cutting data on the dentist side. | 2012-01-05 |
20120003605 | ENDODONTIC DIAGNOSTIC INSTRUMENT - An endodontic diagnostic instrument includes a handle configured for receiving a clamp or retainer which engages and clamps an applicator, which may be made of open-celled foam and which is saturated with a coolant or refrigerant. By utilizing the instrument, a doctor may place or selectively position the applicator against a tooth or multiple teeth to determine the tooth which generates pain. | 2012-01-05 |
20120003606 | CONNECTION OF A PROSTHESIS STRUCTURE WITH AN IMPLANT STRUCTURE - A connection device for connecting a prosthesis structure with an implant structure comprises a holding shell and a retention insert. The retention insert comprises an end side and a substantially ring-shaped retention rim projecting therefrom. The holding shell comprises an end side and a substantially ring-shaped holding rim projecting therefrom. The holding rim and the end side of the holding shell form a retainer in which the retention insert can be arranged such that an outer surface of the retention rim is adjacent to an inner surface of the holding rim. Moreover, the outer surface of the retention rim is at least partly spaced from and adjacent to the inner surface of the holding rim when the retention insert is arranged in the retainer of the holding shell and when essentially no radial forces are acting on the holding rim and on the retention rim. In that the adjacent outer surface of the retention rim and inner surface of the holding rim are at least partly not contacting each other but are spaced from each other when essentially no radial forces are acting on the holding rim and on the retention rim, it can, i.a., be achieved that the retention insert is connected relatively loosely with the holding shell when the connection device has not yet been placed on the implant structure. This loose connection can allow the retention insert to be relatively easily removed from the holding shell and inserted in the holding shell without having to be substantially deformed or strained in any other way. Thus, it is possible to insert and remove the retention insert gently, which can improve the flexibility and lifetime of the connection device. | 2012-01-05 |
20120003607 | DETACHMENT-PREVENTED REMOVABLE DOUBLE-CROWN PROSTHETIC APPLIANCE - A detachment-prevented removable double-crown prosthetic appliance includes an internal crown member, which has an outside surface to which two resilient retention clamping strips are mounted, each of the resilient retention clamping strips including a root section that is fixed to the outside surface of the internal crown member and a spring section extending from the root section, the spring sections of the resilient retention clamping strips being spaced by a gap that has a reduced neck portion forming a pass; and an external crown member, which is removably mounted to the internal crown member and has a lower inner portion forming a fitting chamber for removably fitting over the internal crown member, the fitting chamber having an inside surface that forms a retention block that is engageable with the resilient retention clamping strips so as to securely but removably couple the external crown member to the internal crown member. | 2012-01-05 |
20120003608 | APPARATUS FOR FASTENING A DENTAL PROSTHESIS - The device for fastening a dental prosthesis includes a bar patrix ( | 2012-01-05 |
20120003609 | Dental implant - A dental implant includes a dental implant body which is a cylinder body having a first end and a second end, an asymmetric thread being provided around the dental implant body, an apex lock being formed at the first end for inserting into a sinus of a desired position, and an endomaximum lock being provided at the second end for integrally connected with an abutment through a bolt. The apex lock is a space indented in the first end for enabling new grown bone of the sinus extending into the apex lock to provide a locking mechanism to ensure integration between the dental implant and the bone. The endomaximum lock has a lock cavity having a lock opening at the second end for receiving a root of the abutment therein. | 2012-01-05 |
20120003610 | APPARATUS AND DIGITAL METHODOLOGY FOR PREPARATION OF A DENTAL IMPLANT SURGICAL SITE FOR THE PROMOTION OF A DESIRED EMERGENT SULCUS - One possible embodiment of the invention could be a methodology of creating a proposed sulcus emergence profile for a dental implant surgical site, comprising of the following steps obtaining data of a specific patient's mouth needed to create a computer-generated virtual model of that patient's mouth; processing said obtained data to create a computer-generated virtual model of the patient's mouth; comparing virtual model data as it pertains to a site map of a proposed dental implant surgical site with virtual model data as it pertains to a site map of a mirror location in the mouth of the surgical site, allowing the mirror location site map to be transposed and overlaid upon the site map of the surgical site; and creating from that comparison of virtual model data, a proposed sulcus emergence profile for the implant surgical site. | 2012-01-05 |
20120003611 | MULTIFUNCTIONAL ACRYLATES USED AS CROSS-LINKERS IN DENTAL AND BIOMEDICAL SELF-ETCHING BONDING ADHESIVES - This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators. | 2012-01-05 |
20120003612 | METHODS OF SIMULATING COMBAT - In some embodiments, a method of simulating combat described herein comprises emitting a first query beam from a first query unit of a first interoperable identification and communication system, receiving the first query beam with a second response unit of a second interoperable identification and communication system, emitting a second response beam with the second response unit, and receiving the second response beam with the first query unit. In some embodiments, a method of simulating combat comprises emitting a query beam comprising a plurality of packets each comprising a header portion, an information portion, and a footer portion from a query unit; and receiving the query beam with a response unit comprising a plurality of detectors spatially separated from one another, wherein the response unit is operable to independently measure the intensity of each packet of the query beam received at each of the plurality of detectors. | 2012-01-05 |
20120003613 | Goal Based System Utilizing a Table Based Architecture - A system is disclosed that provides a goal based learning system utilizing a rule based expert training system to provide a cognitive educational experience. The system provides the user with a simulated environment that presents a business opportunity to understand and solve optimally. Mistakes are noted and remedial educational material presented dynamically to build the necessary skills that a user requires for success in the business endeavor. The system utilizes an artificial intelligence engine driving individualized and dynamic feedback with synchronized video and graphics used to simulate real-world environment and interactions. A robust business model provides support for realistic activities and allows a user to experience real world consequences for their actions and decisions and entails realtime decision-making and synthesis of the educational material. The system is architectured around a table of components to manage and control the system. | 2012-01-05 |
20120003614 | Eat Rite Baby - The purpose of this invention, “Eat Rite Baby” is to offer its users a visual interpretation of how proper nutrition and exercise influences appropriate weight maintenance and health. This deed will be accomplished through physical and interactive methods. Sensors placed in the doll's open mouth will react to sensors in accompanying foods which will stimulate the doll into action, thus allowing a simulated weight gain and subsequent weight loss. These sensors will be located within a box that will allow for wires to extend through the baby's body in order to transmit signals to areas that will change. Additionally, the doll will be accompanied by a cd that will further instruct the user on how to live a healthier lifestyle via proper food selections, exercises, food group choices, portion sizes, etc. | 2012-01-05 |
20120003615 | Weight Loss System - A comprehensive integrated weight loss system combines regimens of exercise, nutrition and motivation with a focus upon raising a glycemic threshold to overcome insulin resistance. The diet may be fine-tuned by using feedback mechanisms to assess whether an individual is using a glycemic load that is correct for their individual body. | 2012-01-05 |
20120003616 | Educational Ruler - An educational ruler which includes a body and a sliding member, the sliding member movable to define an isolation window to isolate particular words or phrases for educational purposes | 2012-01-05 |
20120003617 | Spin-It Bingo Math Game - A kit for a mathematical equation and concept learning game based upon traditional Bingo. The kit includes a plurality of boards, each with a 5 by 5 matrix of squares filled with equations in each block of the matrix. A row above the matrix of squares includes the letters S, P, I, N and T above each respective column. Further included is a wheel divided into 100 segments, the first twenty segments marked as S1 through S20, the second twenty segments marked as P21 through P40, the third twenty segments marked as I41 through I60, the fourth twenty segments marked as N61 through N80 and finally the fifth twenty segments marked as T81 through T100. A method is provided to play the game by which the wheel is spun and a letter/number combination is called. Players cover squares of their matrix if the number called is an answer to a labeled equation in the called number and column. The first player to fill five squares horizontally, vertically or diagonally calls out “Spin-It” and wins the game. | 2012-01-05 |
20120003618 | Geo-meter graph reader learning system - The Geo-Meter Graph Reader Learning System comprises a set of physical tools and methods of usage and instruction that aid in the construction and interpretation of graphs, lines, arcs, circles and angles. The physical aspect of the system consists of three components. A first component encompasses customary and metric scales so that the system can be used with all standard graph paper. A second component may be used alone or with the first component when aligning a value on one axis with a value on another axis. A third component, used alone or with the first component, measures angles, constructs arcs and circles, and determines trigonometric values of angles. The Geo-Meter Graph Reader Learning System aids students in, a) constructing and interpreting coordinate, bar, line and circle graphs, b) expressing and determining linear relationships graphically, c) determination of increment size and value, and d) determining the slope and of lines. | 2012-01-05 |
20120003619 | METHOD AND SYSTEM FOR ASSIGNING JOBS TO PREVENT EMPLOYEE QUALIFICATIONS FROM LAPSING - A method for execution by a computing apparatus comprising identifying a job to be assigned to an employee, the job requiring a given job qualification, wherein the given job qualification is associated with at least one requirement for maintaining the job qualification and a time-frame during which the at least one requirement should be satisfied. Completion of the job by an employee at least partially completes the at least one requirement for maintaining the job qualification. The method further comprises assigning the job to a selected employee from a set of employees, wherein each employee in the set of employees has the given job qualification. The selected employee is selected at least in part on a basis of a probability of the selected employee losing the job qualification relative to other employees in the set of employees. | 2012-01-05 |
20120003620 | SYSTEM AND METHOD FOR ADJUSTING TIDAL VOLUME OF A SELF-VENTILATION SUBJECT - A system and method are configured to adjust the tidal volume of the breathing of a subject. The subject is self-ventilating (breathes under her own power). The adjustment of tidal volume accomplished through use of the system and/or method may reduce hypertension (e.g., lower blood pressure), reduce stress and/or anxiety (and related maladies), improve relaxation, decrease sleep latency, improve sleep quality, address other sleep disorders, and/or provide other health benefits. The system and method are effective in adjusting tidal volume while the subject is awake and/or asleep. | 2012-01-05 |
20120003621 | Wearable partial task surgical simulator - A wearable device for simulating wounds and injuries received during a trauma event includes a raiment and vest for covering the torso of a person. The raiment has an outer surface with a color and a texture comparable to human skin. Mounted on the outer surface is at least one wound simulator formed with an orifice that is in fluid communication with a fluid reservoir. Thus, the person can selectively expel a blood-like fluid from the reservoir, and through the wound simulator orifice, to simulate a trauma event. The vest includes an artificial rib cage and prosthetic internal organs juxtaposed with at least one wound simulator to simulate internal effects of a trauma event. | 2012-01-05 |
20120003622 | METHOD FOR INTERACTIVE LEARNING AND TRAINING - Provided is a method comprising delivering a video of an event to a learner that includes a still menu that effectuates and simulates a pause; recording a video of an action by the learner in response to the event; presenting to the learner the video of the action by the learner; presenting to the learner a video showing a preferred action by a master in response to the event; and recording at least one additional action by the learner. Also provided is a method for teaching a learner how to respond to an event comprising allowing the learner to choose among recording an action in response to a video of an event, viewing one or more recorded actions of a master, and comparing the two videos; wherein recording may be chosen before and after either or both viewing and reviewing, and the recordings are viewable as videos on a monitor. | 2012-01-05 |
20120003623 | NONLINEAR MODEL PREDICTIVE CONTROL OF A BATCH REACTION SYSTEM - The present invention provides novel techniques for controlling batch reaction processes. In particular, a parametric hybrid model may be used to parameterize inputs and outputs of batch reaction processes. The parametric hybrid model may include an empirical model, a parameter model, and a dynamic model. Critical quality parameters, which are correlated with, but not the same as, end-of-batch quality values for the batch reaction processes may be monitored during cycles of the batch reaction processes. The quality parameters may be used to generate desired batch trajectories, which may be used to control the batch reaction processes during the cycles of the batch reaction processes. | 2012-01-05 |
20120003624 | STANDARDIZED METHOD AND KIT FOR THE QUANTIFICATION OF HEPATITIS A VIRUS - The present invention provides a standardized method and a kit for an accurate quantification of HAV in clinical and food samples. The general approach is based on the use of several controls to measure the efficiency of those critical steps of the quantification: the nucleic acids extraction and the RT-PCR reactions. The kit comprises: a Mengo virus mutant strain with the same growth properties than those of the wild-type Mengo virus and with no pathogenic capacity; a single stranded RNA molecule corresponding to a fragment of the HAV genome; primers that specifically bind to regions of the 5′ non coding region of the HAV genome; a detectable labeled probe that specifically binds to the amplimer resulting from the RT-PCR; and an appropriate molecule to generate an standard curve for the quantification of HAV. | 2012-01-05 |
20120003625 | METHODS AND KITS FOR DETECTING AN INFECTIOUS AGENT - The present invention provides methods and kits for determining the presence, absence, or level of an infectious agent in a sample. Specifically, the present invention provides methods and kits for detecting or quantifying certain target polynucleotides of the infectious agent. In certain embodiments, the present invention provides for such detection without the need for amplification (e.g., replication) of the target molecule and/or without the need for labor intensive purification procedures. In certain embodiments, the present invention provides positive control and housekeeping gene for normalization and quantatively detection of the copy numbers of infectious agent in a sample. In these or other embodiments, the invention allows for such detection with the desired sensitivity and/or specificity, even where the polynucleotide is present in the sample at low copy number. | 2012-01-05 |
20120003626 | SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS - The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions. | 2012-01-05 |
20120003627 | Portable Fluorescence Reader Device - The present invention describes a device for performing a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The device also includes a compatible slide comprising sample wells. The device detects emitted fluorescence signal through a camera and optics assembly that is controlled by a user interface assembly. | 2012-01-05 |
20120003628 | Methods for Diagnosing Pervasive Development Disorders, Dysautonomia and Other Neurological Conditions - Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker compound) comprising one or more pathogens, which provides an indication of whether the individual has, or can develop, a disorder including, but not limited to, a PDD, Dysautonomia, Parkinsons disease and SIDS. Preferably, the presence of one or more pathogens is determined using a stool immunoassay to determine the presence of antigens in a stool sample, wherein such antigens are associated with one or more pathogens including, but not limited to, | 2012-01-05 |
20120003629 | Biological control of nanoparticle nucleation, shape and crystal phase - The present invention includes compositions and methods for selective binding of amino acid oligomers to semiconductor and elemental carbon-containing materials. One form of the present invention is a method for controlling the particle size of the semiconductor or elemental carbon-containing material by interacting an amino acid oligomer that specifically binds the material with solutions that can result in the formation of the material. The same method can be used to control the aspect ratio of the nanocrystal particles of the semiconductor material. Another form of the present invention is a method to create nanowires from the semiconductor or elemental carbon-containing material. Yet another form of the present invention is a biologic scaffold comprising a substrate capable of binding one or more biologic materials, one or more biologic materials attached to the substrate, and one or more elemental carbon-containing molecules attached to one or more biologic materials. | 2012-01-05 |
20120003630 | MODULAR NUCLEIC ACID-BASED CIRCUITS FOR COUNTERS, BINARY OPERATIONS, MEMORY, AND LOGIC - We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers, by utilizing the >100 known recombinases to create subsequent modules. Flexibility in our engineered genetic counter designs is provided by daisy-chaining individual modular components, i.e., SIMMs together. These modular components of the engineered genetic counters can be combined in other network topologies to create circuits that perform, amongst other things, logic and memory. Our novel engineered genetic counter designs allow for the maintenance of memory and provide the ability to count between discrete states by expressing the recombinases between their cognate recognition sites. | 2012-01-05 |
20120003631 | INSTRUMENT FOR CASSETTE FOR SAMPLE PREPARATION - A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system. | 2012-01-05 |
20120003632 | FRET-PROBES AND USE THEREOF - This invention relates to the detection of among others tumor-specific fusion proteins and protein interactions. Provided is a set of at least a first and a second molecular probe, each probe provided with a dye wherein said dyes together allow energy transfer, each probe additionally provided with a reactive group allowing juxtaposing said at least first and second probe, wherein said reactive group is an oligonucleotide and wherein the reactive group of said first probe is not directly reactive with the reactive group of said second probe. | 2012-01-05 |
20120003633 | MEANS AND METHODS FOR INVESTIGATING NUCLEIC ACID SEQUENCES - The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid. | 2012-01-05 |
20120003634 | IDENTIFICATION OF SOURCE OF DNA SAMPLES - The present disclosure relates to methodology for fast and cost-effective identification of the source of DNA samples. DNA samples obtained from unknown or unrecognized tissues or cell types are analyzed according to the methodology described herein, yielding an identification of the tissue and/or cell type source. Identification is based on sequential biochemical procedures including methylation sensitive/dependent restriction and polymerase chain reaction, followed by analysis of the data. All biochemical steps are performed in a single test tube. The disclosure has immediate applications in forensic science for identification of the tissue source of DNA obtained from biological stains. The disclosure also has immediate applications in cancer diagnosis for identification. | 2012-01-05 |
20120003635 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 2012-01-05 |
20120003636 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 2012-01-05 |
20120003637 | DIAGNOSING FETAL CHROMOSOMAL ANEUPLOIDY USING MASSIVELY PARALLEL GENOMIC SEQUENCING - Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes. | 2012-01-05 |
20120003638 | KIT FOR HIGH THROUGHPUT MUTATION SCREENING METHODS - One example embodiment includes a kit to execute a method of simultaneously screening for genetic mutations in different genes in a multitude of samples. The kit includes an antisense deoxyribonucleic acid (DNA) probe, where the antisense DNA probe will be mixed with a strand of a ribonucleic acid (RNA) to be tested to form a heteroduplex molecule within a sample. The kit also includes a ribonuclease enzyme, an RNA-primed DNA polymerase, a single strand-specific nuclease, DNA-dependent DNA polymerase, a blocking adapter and a tagged reporter adapter. Through ribonuclease digestion, differential sequence fill-in (DSF) and full-length sequence extension, tagged mutant-dual adapter hybrids are formed for detection, quantification or amplification. The sequence ubiquity of said mutant-dual adapter hybrids enables the use of universalized primers for sequence amplification regardless of the numbers or the origins of the mutations involved. | 2012-01-05 |
20120003639 | CANCER BIOMARKERS AND METHODS OF USE THEREOF - Embodiments are provided for characterizing a biological sample. In some embodiments, one can estimate the risk that a subject with ductal carcinoma in situ will have a subsequent DCIS event and/or invasive cancers. | 2012-01-05 |
20120003641 | GENETIC POLYMORPHISMS IN AGE-RELATED MACULAR DEGENERATION - Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody. | 2012-01-05 |
20120003642 | OLIGONUCLEOTIDES AND METHODS FOR DETERMINING SUSCEPTIBILITY TO SOFT TISSUE INJURIES - A method of determining in a subject a predisposition to, or increased risk for, developing a tendon, ligament, or other soft tissue injury or pathology, the method comprising the step of screening the subject for the presence of at least one poly-morphism in at least one gene family selected from the group consisting of any one or more of: the matrix metallo-protease (MMP) family, the collagen family, including the COL5A1 and COL12A1 genes, the glycoprotein family, including the TNC and COMP genes, and derivatives thereof, which polymorphism is a polymorphism which results in a modified, augmented, or gated interaction with other members of the gene families mentioned herein, when compared to a wild-type interaction. | 2012-01-05 |
20120003643 | ENRICHMENT AND IDENTIFICATION OF FETAL CELLS IN MATERNAL BLOOD AND LIGANDS FOR SUCH USE - The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive prenatal diagnostics. | 2012-01-05 |
20120003644 | METHODS AND KITS FOR DETERMINING PREDISPOSITION TO DEVELOP KIDNEY DISEASES - Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on | 2012-01-05 |
20120003645 | Compositions, Methods and Kits for Nucleic Acid Synthesis and Amplification - The present invention is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in a one-step RT-PCR procedure comprising one or more agents used to increase tolerance to PCR inhibitors. | 2012-01-05 |
20120003646 | METHOD AND APPARATUS FOR IDENTIFYING ANALYTE-CONTAINING SAMPLES USING SINGLE-READ DETERMINATION OF ANALYTE AND PROCESS CONTROL SIGNALS - Apparatus and method for detecting analyte in a reaction mixture comprising an internal control. The invention is illustrated using amplification and detection of nucleic acids, where the amplification reaction comprises an exogenous internal control. Magnitude of the detection signal serves as the variable for identifying invalid trials, identifying valid trials that are negative for analyte, and identifying trials that are positive for analyte. Detection of a signal indicating probe hybridization can be used for assigning the presence or absence of analyte nucleic acid in validated reactions using only a single detectable label, and without distinguishing the proportion of signal contributed by internal control probe binding, and analyte probe binding. | 2012-01-05 |
20120003647 | GENETIC POLYMORPHISMS IN THE PROSTATE-SPECIFIC ANTIGEN GENE PROMOTER - The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene. | 2012-01-05 |
20120003648 | Signal Multiplexing and Signal Amplification - Disclosed are methods, compositions and kits for amplifying signals for detecting the presence, quantity and/or sequence of nucleic acids and proteins, as well as methods, compositions and kits for increasing the number of such targets simultaneously detectable in a sample. Detection may be, for instance, in vivo, in cellulo or in situ. Amplification of signal is achieved by way of hybridization of nucleic acid label probe systems and structures. Increase in target multiplex capacity is achieved by way of varying the type of labels utilized in the nucleic acid label probe system. | 2012-01-05 |
20120003649 | METHODS FOR ASSESSING RISK OF ALZHEIMER'S DISEASE IN A PATIENT - Disclosed are methods for diagnosis or prognosis of Alzheimer's disease in a patient. The methods may include assessing whether a patient has Alzheimer's disease or assessing a patient's risk for developing Alzheimer's disease. The methods typically include determining, either directly or indirectly, whether the patient has mutations, such as single nucleotide polymorphisms, in a plurality of genes that encode gene products that function in steroid biosynthesis. | 2012-01-05 |
20120003650 | MARKER FOR PRENATAL DIAGNOSIS AND MONITORING - The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status. | 2012-01-05 |
20120003651 | TAGGED OLIGONUCLEOTIDES AND THEIR USE IN NUCLEIC ACID AMPLIFICATION METHODS - The present invention provides nucleic acid amplification methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results. | 2012-01-05 |
20120003652 | Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species - Essential genes coding for the metabolic pathway of solventogenic autotrophic Clostridia were sequenced, and functionality was confirmed. The present invention utilizes a comparative inter-species approach to develop the minimum set of essential genes for metabolic function and estimate productivity in species of suspected solventogenic capability. | 2012-01-05 |
20120003653 | COMPOSITIONS AND METHODS FOR DETECTING MUTATIONS IN JAK2 NUCLEIC ACID - The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease. | 2012-01-05 |
20120003654 | MAGNETIC LYSIS METHOD AND DEVICE - A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a speed sufficient to lyse the cells. Also disclosed is a device for lysing cells. The device includes a container having a magnetic stir element and a plurality of cell lysis beads disposed therein. The container is dimensioned to allow rotation of the magnetic stir element inside the container. | 2012-01-05 |
20120003655 | IDENTIFICATION OF NEUROPROTECTIVE AGENTS USING PRO-INFLAMMATORY HUMAN GLIAL CELLS - Provided herein are methods for, inter alia, identifying new therapeutic agents using human cell-based models. | 2012-01-05 |
20120003656 | SAMPLE PREPARATION FOR IN SITU NUCLEIC ACID ANALYSIS, METHODS AND COMPOSITIONS THEREFOR - Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried out at room temperature in as little as seven minutes and is amenable to high throughput processing using manual or robotic platforms. | 2012-01-05 |
20120003657 | TARGETED SEQUENCING LIBRARY PREPARATION BY GENOMIC DNA CIRCULARIZATION - Certain embodiments provide a method of sequencing that comprises: a) contacting, under hybridization conditions, a target genomic fragment with: i. a vector oligonucleotide comprising a binding site for a sequencing primer; and ii. a splint oligonucleotide that hybridizes to the vector oligonucleotide and to the nucleotide sequences at the ends of a target genomic fragment, to produce a circular nucleic acid; b) contacting the circular nucleic acid with a ligase, thereby ligating the ends of the vector oligonucleotide to the ends of the target genomic fragment to produce a circular DNA molecule; c) separating the circular DNA molecule from the splint oligonucleotide; and d) sequencing the target genomic fragment of the circular DNA molecule using the first sequencing primer. | 2012-01-05 |
20120003658 | MICROFLUIDIC DROPLET QUEUING NETWORK - A multi-port liquid bridge ( | 2012-01-05 |
20120003659 | STROBO THIN FILM CHEMICAL ANALYSIS APPARATUS AND ASSAY METHOD USING THE SAME - Disclosed are a strobo thin film chemical analysis apparatus based on the stroboscope principle and an assay method using the same. The strobo thin film chemical analysis apparatus is suitable for real-time analysis for a rotatable bio disc such as a lab on a disc integrated with bio chips such as a lab on a chip, a protein chip and a DNA chip for diagnosing or detecting a small quantity of materials in fluids. | 2012-01-05 |
20120003660 | DIAGNOSIS OR PROGNOSIS OF BREAST CANCER BASED ON EXPRESSION LEVEL OF THIOREDOXIN-1 - The present disclosure relates to a diagnostic marker for breast cancer, having thioredoxin-1 as an active ingredient, and to a diagnostic kit for breast cancer using same. The thioredoxin-1 is overexpressed in human breast cancer tissue so as to enable the early diagnosis of breast cancer or the early prediction prognosis of breast cancer, and therefore has a valuable use as a diagnostic marker for breast cancer. | 2012-01-05 |
20120003661 | METHODS AND DEVICES FOR THE SELECTIVE DETECTION OF MICROORGANISMS - Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabilizes or lyses the microorganism; contacting the selectively permeabilized microorganism with a detection reagent that is taken into the selectively permeabilized organism or that contacts metabolites or enzymes released by the selectively permeabilized microorganism, where the detection reagent produces a signal in the presence of said metabolites or enzymes; and detecting a signal produced by the detection reagent in the presence of the metabolites or enzymes wherein the strength of the signal indicates the presence and/or amount of the target microorganism in the sample. | 2012-01-05 |
20120003662 | Methods and Kits for Detecting Mastitis - Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein. Components and reagents for use in the kits and assays are also disclosed. | 2012-01-05 |
20120003663 | Method of rapidly quantifying hydroxymethylated DNA - This invention is related to a method for rapidly quantifying hydroxymethylated DNA by binding DNA to a plastic carrier followed by immunodetection of 5-hydroxymethylcytosine or a hydroxymethylcytosine structure that is marker of DNA hydroxymethylation. | 2012-01-05 |
20120003664 | METHOD FOR EVALUATING PRE-TREATMENT - The present invention relates to methods for evaluating tissue pre-treatment such as ischemic time, fixation time and alcohol time in an immunohistochemical assay by using one or more internal controls. Said internal controls may be biomarker specific or tissue specific. Also included are uses and kits comprising said internal controls. | 2012-01-05 |
20120003665 | Dissolved Protein Arthritis Markers - Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample. | 2012-01-05 |
20120003666 | METHOD OF DETECTING TARGET SUBSTANCE - Provided is a method of measuring a being state of a target substance at unknown concentration contained in a sample. The method includes identifying a kind of a target substance when one kind of target substance is contained in a sample and determining a concentration ratio when plural kinds of target substances are contained in the sample: by obtaining, with respect to each of plural kinds of known substances having the same recognition site, a relationship between Parameter A of the known substance and Parameter B of the known substance; and measuring Parameter A of the target substance contained in the sample and Parameter B of the target substance contained in the sample, wherein Parameter A of X is a value derived from a number of molecules of X and Parameter B of X is a value derived from the number and a molecular weight of X. | 2012-01-05 |
20120003667 | ELECTROPHORETIC TAG-BASED IN VITRO ASSAY TO QUANTIFY DIMERIZATION OF P66 AND P51 SUB-UNITS OF HIV-1 REVERSE TRANSCRIPTASE (RT) - Methods for measuring hetero- and homodimerization of HIV reverse transcriptase (HIV RT) are provided using pairs of tagged probes and cleaving probes. The methods can be used, for example, to screen for modulators of HIV RT dimerization. Also provided are methods of determining whether a compound modulates HIV RT. Further provided are methods of determining whether a compound modulates formation of a complex between a p66 and p51, p66 and p66, or p51 and p55 subunits polypeptides of HIV RT. | 2012-01-05 |
20120003668 | HIGH RESOLUTION COMPLEX STRUCTURE AND ALLOSTERIC EFFECTS OF LOW MOLECULAR WEIGHT ACTIVATORS ON THE PROTEIN KINASE PDK1 - The present invention provides a mutant form of a protein kinase its production and its use for identifying compounds that bind to the PIF-binding pocket allosteric site of the protein kinase. | 2012-01-05 |
20120003669 | Immunohistochemical staining method and immunohistochemical staining apparatus - An immunohistochemical staining apparatus for carrying out immunohistochemical staining includes a sample chamber ( | 2012-01-05 |
20120003670 | Methods and Kits for Measuring Von Willebrand Factor - Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having at least two of a G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Ibα and von Willebrand factor. | 2012-01-05 |
20120003671 | METHODS FOR ANTIBODY ENGINEERING - The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of a number of related antibodies that each bind to the same antigen as the parent antibody. The amino acid at the substitutable position may be substituted for a different amino acid without significantly affecting the activity of the antibody. The subject methods may be employed to change the amino acid sequence of a CDR without significantly reducing the affinity of the antibody of the antibody, in humanization methods, or in other antibody engineering methods. The invention finds use in a variety of therapeutic, diagnostic and research applications. | 2012-01-05 |
20120003672 | IN VITRO-METHOD FOR THE DIAGNOSIS, PROGNOSIS, MONITORING AND THERAPY FOLLOW-UP OF DISORDERS ASSOCIATED WITH THE METABOLIC SYNDROME, A CARDIOVASCULAR DISEASE AND/OR INSULIN RESISTANCE - The present invention relates to an in vitro-method for diagnosis, prognosis and/or monitoring/therapy follow-up of a disorder of the metabolic system and/or cardiovascular system and/or insulin resistance in a subject, comprising the determination of the relative level of one or more cardiovascular markers in a sample of a subject and the use of the determined relative level of said one or more cardiovascular peptides for the diagnosis, prognosis and/or monitoring/therapy follow-up of a disorder of the metabolic system and/or cardiovascular system and/or insulin resistance in said subject. | 2012-01-05 |
20120003673 | Screening method, composition containing substance selected by the screening method, and binding substance - Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF. The screening method is characterized in that a test substance capable of enhancing the binding between a polypeptide belonging to the thioredoxin family and a macrophage migration inhibitory factor is selected through the steps of mixing at least one binding substance selected from the substances (1) to (4) shown below with the test substance, allowing the binding substance to bind to the macrophage migration inhibitory factor, and confirming the binding between the binding substance and the macrophage migration inhibitory factor: (1) a polypeptide belonging to the thioredoxin family; (2) a protein which comprises an amino acid sequence produced by deleting, substituting or adding one or several amino acid residues in an amino acid sequence for a polypeptide belonging to the thioredoxin family and has the same activity as that of a polypeptide belonging to the thioredoxin family; (3) a gene encoding the polypeptide (1); and (4) a gene encoding the protein (2). | 2012-01-05 |
20120003674 | Chloral Hydrate Detection - The invention relates to an immunoassay method and kit for the indirect detection of chloral hydrate. The invention is underpinned by a novel immunogen that produces an antibody that is specific for the chloral hydrate metabolite trichloroethanol glucuronide. Detection and quantification of trichloroethanol glucuronide has important applications in clinical toxicology, drug facilitated crime, water testing and solvent exposure. | 2012-01-05 |
20120003675 | Method for Preparing Small Volume Reaction Containers - Engineered reaction containers that can be physically and chemically defined to control the flux of molecules of different sizes and charge are disclosed. Methods for constructing small volume reaction containers through a combination of etching and deposition are also disclosed. The methods allow for the fabrication of multiple devices that possess features on multiple length scales, specifically small volume containers with controlled porosity on the nanoscale. | 2012-01-05 |
20120003676 | MASS SPECTROMETRY ASSAY FOR THIOPURINE-S-METHYL TRANSFERASE ACTIVITY AND PRODUCTS GENERATED THEREBY - Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample. | 2012-01-05 |
20120003677 | IDENTIFICATION OF TISSUE FOR DEBRIDEMENT - Provided are methods of determining whether a cell in a tissue site is viable or nonviable. Also provided are methods of debriding tissue from a tissue site. Further provided are kits comprising a compound that distinguishes between viable and nonviable cells and instructions for using the compound on a tissue site. Additionally, the use of a compound that distinguishes between viable and nonviable cells is provided, where the use is to determine whether a cell in a tissue site is viable or nonviable. Also provided is a use of a compound that distinguishes between viable and nonviable cells, where the use is for the manufacture of the above-described kit. | 2012-01-05 |
20120003678 | NOVEL FRUCTOSYL PEPTIDE OXIDASE - A protein described in any one of [1] to [4] below is provided according to the present invention:
| 2012-01-05 |
20120003679 | SENSOR MODULE, TISSUE PROCESSOR, AND METHOD FOR OPERATING A TISSUE PROCESSOR - A sensor module ( | 2012-01-05 |
20120003680 | ASSEMBLY OF ABSOLUTELY QUANTIFIED PEPTIDE AND PHOSPHOPEPTIDE SOLUTIONS VIA ELEMENT MASS SPECTROMETRY - The present invention relates generally to the fields of analytics of proteins and peptides. More particularly, the invention concerns generation of an absolutely quantified reference peptide or protein solution via element mass spectrometry. Furthermore, the invention relates to the absolute quantification of phosphopeptides and peptides by the use of an absolutely quantified peptide solution. | 2012-01-05 |
20120003681 | EX VIVO METHOD FOR DETERMINING POTENTIAL GLP-2 RECEPTOR MODULATIONS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 2012-01-05 |
20120003682 | MICROFABRICATED APPARATUS FOR CELL BASED ASSAYS - Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel and an outlet channel, a cover plate positioned over the base plate to define the chambers and connecting channels. Means are incorporated in the cell growth chambers, for cell attachment and cell growth. In particular, the invention provides a rotatable disc microfabricated for performing cell growth and cell based assays. The apparatus and method can be used for the growth of cells and the detection and measurement of variety of biochemical processes and products using non-invasive techniques, that is techniques which do not compromise the integrity or viability of cells. | 2012-01-05 |
20120003683 | CELLS FOR INDICATING THE PRESERVATION OF BIOLOGICAL SAMPLES - Methods of characterizing the extent to which a biological sample preserved at a very low temperature has been exposed to stress using indicator cells is provided. | 2012-01-05 |
20120003684 | Method and Means for Detecting the Activity of Osteoclasts - The invention relates to a method and means for detecting the resorption activity of osteoclasts, in particular for use in medicine and in bioscience and pharmaceutical research. Previous methods for measuring the resorption activity of osteoclasts in vitro are difficult to quantify, are partially inflexible when used with different donor organisms and require special measuring devices for data acquisition. The method and kit according to the invention advantageously use a biomineralized matrix which contains calcium phosphate and was obtained in vitro by depositing calcium phosphate by means of osteoblasts. Osteoclasts are incubated on this matrix and the non-resorbed calcium phosphate is then quantified. The method according to the invention advantageously functions with osteoclasts of different organisms and cell types and can be easily quantified. | 2012-01-05 |
20120003685 | DIAGNOSTIC COMPOSITION AND ARTICLE FOR MONITORING INTRAVAGINAL INFECTIONS - The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the buffer capacities associated with vaginal secretions. The diagnostic composition provides a visible indication of vaginal infections, such as bacterial vaginosis. | 2012-01-05 |
20120003686 | CULTURE PLATE HOLDER - The present disclosure describes holder devices, testing kits that include the holder devices, and methods for using the holder devices to allow a user to dispense an aqueous test sample from a sampling device onto a culture plate device having a cover sheet, whereby the cover sheet is supported in an open position by the holder while the user dispenses the aqueous test sample onto a base member of the culture plate device. | 2012-01-05 |
20120003687 | METHODS FOR COUNTING CELLS - The invention features methods of quantifying cells in a sample by lysing the cells followed by the measurement of at least one intracellular component. Methods of the invention are especially useful for quantifying small numbers of cells, e.g., over a large surface area or volume compared to the cell size. In a preferred embodiment, methods of the invention are performed using a microfluidic device. | 2012-01-05 |
20120003688 | COMPOSITIONS AND METHODS FOR USING NADH OXIDASES - The present disclosure relates generally to bacterial NADH oxidases and, more particularly, to novel NADH oxidases obtained from | 2012-01-05 |
20120003689 | HYDROPHOBIC MAGNETIC PARTICLES - A process for making a particulate material comprising mesoporous particles having granules of a metal containing species in at least some of the pores thereof, said process comprising: allowing a compound of the metal to enter pores of hydrophobic mesoporous particles, said compound being thermally decomposable at a decomposition temperature to form a metal containing species and said particles being substantially thermally stable at said decomposition temperature; and heating the hydrophobic mesoporous particles having the compound in the pores thereof to the decomposition temperature so as to decompose the compound and to form the mesoporous particles having granules of the metal containing species in at least some of the pores thereof. | 2012-01-05 |
20120003690 | ENZYMATIC GENERATION OF FUNCTIONAL LIPIDS FROM CEREALS OR CEREAL BI-STREAMS - The present invention relates to the modification of lipids in lipid-containing plant material, such as cereal bran for the generation of functional lipids. The present invention further relates to the preparation of compositions comprising such functional lipids as well as the use of these compositions comprising functional lipids and other functional compounds derived from the action of lipid modifying enzymes for the preparation of composition suitable for the preparation of bio-ethanol as well as food products, such as bread. | 2012-01-05 |
20120003691 | METHOD OF ISOLATION AND PURIFICATION OF TRYPSIN FROM PRONASE PROTEASE AND USE THEREOF - The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT. | 2012-01-05 |
20120003692 | METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER - A method of producing an α-L-aspartyl-L-phenylalanine-β-ester by forming the α-L-aspartyl-L-phenylalanine-β-ester from L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to selectively link L-phenylalanine to an α-ester site of the L-aspartic acid-α,β-diester through a peptide bond. | 2012-01-05 |
20120003693 | NOVEL PEPTIDE-FORMING ENZYME GENE - DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by using a culture of a microbe belonging to the genus | 2012-01-05 |
20120003694 | Bioengineered Protein Pores | 2012-01-05 |
20120003695 | METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS - Lower eukaryotic cells such as | 2012-01-05 |
20120003696 | DIAGNOSTIC METHODS FOR DISEASES BY SCREENING FOR HEPCIDIN IN HUMAN OR ANIMAL TISSUES, BLOOD OR BODY FLUIDS, MONOCLONAL ANTIBODIES SPECIFIC TO HUMAN HEPCIDIN AND ASSOCIATED USES THEREFOR - The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the amino acid sequence between and including amino acids 60 and 84, or, in another embodiment, amino acids 74 and 81, as aligned with the human pre-pro-hepcidin precursor protein, and quantifying the pro-hepcidin and/or mature hepcidin level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of prohepcidin/mature hepcidin is indicative of the disease condition. The present invention also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin. | 2012-01-05 |
20120003697 | HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR - A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K | 2012-01-05 |
20120003698 | LINEAR AMPLIFICATION OF SHORT NUCLEIC ACIDS - The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly amplifying a collection of micro RNAs by using temperature cycling during a reverse transcription reaction. The cycling can comprise at least 20 cycles of an annealing temperature segment of 10° C.-30° C., and a denaturation temperature segment of 35° C.-60° C. In some embodiments, the temperature cycled reaction can comprise an osmolyte. | 2012-01-05 |
20120003699 | SEPARTION OF TAGGED FRAGMENTS - Methods of separating tagged nucleic acid fragments from populations of fragments are provided. The fragments are produced from a population of tagged nucleic acids. In some cases, the population of tagged nucleic acids comprises a population of clonal nucleic acids. | 2012-01-05 |
20120003700 | Thermostable Alpha-Amylases - The present invention relates to an isolated polynucleotide comprising an open reading frame encoding a polypeptide having alpha-amylase activity, the polypeptide selected from the group consisting of:
| 2012-01-05 |
20120003701 | Heterologous Expression of Termite Cellulases Yeast - The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast | 2012-01-05 |