Class / Patent application number | Description | Number of patent applications / Date published |
514170100 | Cartilage affecting | 19 |
20110082086 | MEDICAMENT FOR USE IN CONNECTION WITH CARTILAGE IMPAIRMENT - Use of a substance for treating joint medical conditions. The use includes the use of alpha-ketoglutarate acid. | 04-07-2011 |
20110201556 | METHODS OF TREATING CARTILAGE DEFECTS - The present invention provides methods of repairing and regenerating cartilage tissue by administering into the cartilage or the area surrounding the cartilage a composition comprising a therapeutically effective amount of a morphogenic protein. | 08-18-2011 |
20110275573 | TISSUE ADHESIVE - Provided is an adhesive for adhering tissues. The adhesive includes a scaffolding and one or more peptides or proteins capable of binding to cells of both the first and second tissues. In a embodiment, the proteins or peptides have an amino acid sequence that is a subsequence of a ficolin protein, for example, a human ficolin. | 11-10-2011 |
20120108516 | THE USE OF MIDKINE PROTEIN AND THE PROTEIN-CONTAINING MEDICAL DEVICE - The applications and medical devices of Midkine in the field of biotechnology are described in this invention. This invention describes the applications of the protein as follow in (a) or (b) in preparing drugs for promoting cartilage growth or treating cartilage diseases, the protein as a growth factor for promoting chondrocyte proliferation, or medical devices containing this protein: (a) the protein whose amino acid sequence is shown as SEQ ID NO.1; (b) the proteins whose amino acid sequence have at least 60% homology comparing with amino acid sequence described in (a) and have activity for promoting proliferation of chondrocyte. The protein described in this invention promotes proliferation of three types of chondrocytes and is used for preparing drugs for treating cartilage disease. It may provide new therapy for treating cartilage diseases clinically, and new technology for expansion of chondrocytes in vitro for cartilage tissue engineering. | 05-03-2012 |
20120122791 | SUBSTRATE FOR CARTILAGE CULTIVATION USING ARTIFICIAL COLLAGEN, AND METHOD FOR CARTILAGE REGENERATION TREATMENT USING THE SUBSTRATE - Provided are a substrate for cartilage cultivation, which exhibits high safety and has a growth promoting effect on cartilage cells, and a method for cartilage regeneration treatment. The substrate for cartilage cultivation containing artificial collagen, in particular, an artificial collagen aqueous solution has a growth promoting effect on cartilage cells. A cartilage regeneration effect is obtained by the intraarticular injection of the substrate in and around a cartilage defect site. | 05-17-2012 |
20120135934 | COMBINED PREPARATION FOR TREATING JOINT DISEASES - An object of the present invention is to enable the repair and regeneration of articular cartilage, which could not be achieved by conventional therapies, and to provide a safe and inexpensive agent that is effective for the treatment of joint diseases such as osteoarthritis. According to the present invention, a combined formulation for simultaneously, separately, or sequentially administering a hyaluronic acid and an animal mucin-type glycoprotein for the treatment of joint diseases is provided. | 05-31-2012 |
20130116186 | LUBRICIN INJECTIONS TO MAINTAIN CARTILAGE HEALTH - Disclosed are novel methods of maintaining articular cartilage health in an atraumatic, non-diseased joint of a mammal, either human or non-human. The methods involve injecting into the joint capsule of the mammal an amount of a lubricin polypeptide to prevent shear-induced chondrocyte apoptosis and to maintain a lubricin-expressing phenotype of chondrocytes. | 05-09-2013 |
20130116187 | ARTIFICIAL CARTILAGE AND ITS PRODUCTION METHOD - An artificial cartilage comprising 15-95% by mass of collagen, 4.9-70% by mass of proteoglycan, and 0.1-20% by mass of hyaluronic acid. | 05-09-2013 |
20130281378 | Articular Cartilage Mimetics - This invention relates to articular cartilage mimetics and processes to make them using a composite of and electrospun fiber and a hydrogel. | 10-24-2013 |
20130324473 | Coagulating Collagen and Means for Preparing Same - The invention relates to the preparation and provision of a gelling collagen composition that instantaneously forms a collagen matrix, and means for the preparation and use thereof, in particular as part of a therapeutic treatment. | 12-05-2013 |
20140213524 | COMPOSITION FOR REGENERATION OF CARTILAGE - A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination. | 07-31-2014 |
20140221294 | SULPHATED HYALURONIC ACID FOR TREATING DEGENERATIVE OSTEOARTHRITIS - This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis. | 08-07-2014 |
20140256643 | PEPTIDES AND COMPOSITIONS FOR TREATMENT OF JOINT DAMAGE - The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis. | 09-11-2014 |
20140288002 | EXTRACELLULAR MATRIX-BINDING SYNTHETIC PEPTIDOGLYCANS - This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use. | 09-25-2014 |
20140364372 | REGENERATION AND REPAIR OF MESENCHYMAL TISSUE USING AMELOGENIN - A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective amount of amelogenin. | 12-11-2014 |
20150065428 | METHOD FOR ARTICULAR CARTILAGE AND JOINT FORMATION - The invention is a method of applying a joint inducing protein preferably BMP-9 or BMP-3 to an ossification center in order to create a joint, articular cartilage, or an endochondral cap. The ossification center may be one that occurs naturally such as in the case of amputation, wound healing or fracture, or, it may be artificially induced by the application of an ossification center inducing protein, which may include other BMP family proteins such as BMP-2, BMP-4 or BMP-7. Further, this invention is a method of producing joints, or joint-like structures in vitro by application of BMP-9 to cells derived from tissue regions capable of producing ossification centers, such as digit-derived fibroblasts. | 03-05-2015 |
20150141344 | COMPOSITION FOR REPAIRING CARTILAGE TISSUE, METHOD FOR PRODUCING SAME, AND USE THEREOF - The present invention relates to a composition for repairing cartilage tissue, to a method for producing same, and to the use thereof. The present invention provides a composition for repairing cartilage tissue, which is obtained by mixing collagen and hyaluronic acid using a two-way syringe or a mixer, wherein the collagen has a diluted concentration of 5-60 mg/mL excepting water or a physiological phosphate buffer solution, and the hyaluronic acid has a diluted concentration of 5-20 mg/mL excepting water or a physiological phosphate buffer solution. | 05-21-2015 |
20160067309 | COMPOSITION FOR REGENERATION OF CARTILAGE - A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination. | 03-10-2016 |
20160375174 | PEGYLATED FIBRINOGEN PRECURSOR MOLECULE - The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides PEGylated-fibrinogen scaffold and methods of generating and using same for treating disorders requiring tissue regeneration. | 12-29-2016 |