Entries |
Document | Title | Date |
20080200992 | IN VIVO HYDRAULIC FIXATION INCLUDING BIO-RIVETS USING BIOCOMPATIBLE EXPANDABLE FIBERS - The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel. | 08-21-2008 |
20080208358 | Nanofilament Scaffold for Tissue Regeneration - A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75% of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration. | 08-28-2008 |
20080208359 | DURAL GRAFT AND METHOD OF PREPARING THE SAME - A dural graft is provided having improved stiffness characteristics relative to conventional dural substitutes. The dural graft can be formed from a collagen material having a stiffness between about 0.1 pounds per inch (lb./in.) and 0.25 lb./in. Relative to the collagen material forming conventional dural graft substitutes, the decreased stiffness of the collagen material of the present dural graft can provide the graft with a relatively improved or increased pliability. As a result of the increased pliability, the dural graft can sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The reduced stiffness of the collagen material can also provide for a relatively improved or increased flexibility or elasticity of the dural graft. The increased flexibility of the dural graft minimizes tearing of the graft when handled or manipulated during an implantation procedure. | 08-28-2008 |
20080221704 | Three (3) distinct improvements (different fields of use) to the prior art or invention entitled instant face-lifter - There are three distinct improvements on the Instant Face-Lifter -the prior art-: Field of Use “A”, an intra-scalp round or oval-shaped device made of a biocompatible material, typically measuring | 09-11-2008 |
20080249637 | PARTIALLY BIODEGRADABLE THERAPEUTIC IMPLANT FOR BONE AND CARTILAGE REPAIR - Exemplary embodiment of the present invention is directed to an at least partially biodegradable implant suitable for implantation into a subject for repairing a bone or cartilage defect, comprising a three-dimensional open-celled framework structure made of a non-particulate first material, the framework structure being embedded in a second, non-particulate material different from said first material, or the open-celled framework structure being substantially completely filled with said second, non-particulate material, wherein at least one of the first material or the second material is at least partially degradable in-vivo. Furthermore, the present invention is directed to a method for repairing a bone or cartilage defect in a living organism, comprising implanting an implant according to the exemplary embodiment of the present invention into the defective bone or cartilage, or replacing the defective bone or cartilage at least partially. | 10-09-2008 |
20080275569 | Tissue Augmentation Device - A medical device and methods for filling tissue are disclosed. The device has a first configuration for delivery into tissue to be filled and a second configuration in which the device either expands, or is forced to expand within the tissue to be filled. The exterior profile of the expanded device may be customized along its length, to achieve a desired result. The device is adapted to be placed in the skin, and may be used to reduce facial wrinkles or augment facial features such as the lips. | 11-06-2008 |
20080281433 | METHODS AND DEVICES TO CREATE A CHEMICALLY AND/OR MECHANICALLY LOCALIZED PLEURODESIS - A localized pleurodesis for lung devices created utilizing a combination of a mechanical component and a chemical component. The chemical component is utilized to create an acute adhesion between the visceral pleural membrane and parietal pleural membrane while the mechanical component is utilized to create a chronic adhesion. | 11-13-2008 |
20080281434 | Tissue Engineering Using Pure Populations Of Isolated Non-Embryoblastic Fetal Cells - The present invention relates to methods for the in vitro production of mammalian tissue replacements using substantially pure populations of isolated non-embryoblastic fetal cells having the capacity to differentiate into the cell type(s) that form(s) the native tissue. The tissue replacements engineered by the methods of the present invention are especially useful for the repair of non-functional or malfunctional cardiovascular structures in patients suffering from congenital cardiovascular disorders. | 11-13-2008 |
20080288084 | Precursor of a tissue regenerating instrument provided with a swellable rod - The present invention provides a precursor for producing a tissue regenerating instrument that regenerates a tissue, including: a tube made of a biodegradable material provided with a lumen in a longitudinal direction; a rod made of a biodegradable material swellable with a softening solvent, fixed to an inner wall of the tube substantially parallel to the longitudinal direction of the tube; and a fixing means that fixes the rod to the inner wall of the tube, in which the rod in a non-swelled state has a occupied cross-sectional area perpendicular to the longitudinal direction is smaller than a cross-sectional area of the lumen of the tube, and the occupied cross-sectional area perpendicular to the longitudinal direction of the rod in a saturated swelled state with the softening solvent is substantially the same as the cross-sectional area of the lumen of the tube. | 11-20-2008 |
20080288085 | VIVO SYNTHESIS OF CONNECTIVE TISSUES - The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible scaffolds such as collagen sponges soaked with a collagenic amount of a member of the TGF-β family of proteins. This composition is then implanted in a host to produce cranial sutures, periodontal ligament or other fibrous tissue structures in vivo. | 11-20-2008 |
20080300691 | Biomimetic Synthetic Nerve Implant Casting Device - A biomimetic biosynthetic nerve implant (BNI) casting device includes a matrix casting tube; a matrix casting tube protective shield comprising a male coupling portion joinable to a female coupling portion, wherein the joined portions encase the matrix casting tube; microchannel forming fibers; a fixing point for holding one end of the microchannel forming fibers; loading fiber guideholes for placement of the microchannel forming fibers; one or more ports for injection of matrix material into the casting tube; and a cell suspension loading well in fluid communication with the matrix casting tube when the device is fully assembled such that removing the fibers from the formed implant can draw fluid containing cells and/or other agents into the microchannels. | 12-04-2008 |
20080306610 | TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS - Methods for processing tissues to render them suitable for implantation, e.g. in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis, increasing permeability of the extracellular matrix, degrading the debris from lysis, and removing the debris. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed. | 12-11-2008 |
20080306611 | BIOCOMPATIBLE IMPLANTS AND METHODS OF MAKING AND ATTACHING THE SAME - The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided. | 12-11-2008 |
20080312751 | Tissue patches and related delivery systems and methods - Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A tissue patch includes a substrate, a tissue implant attached to the substrate, and a protective liner covering at least a portion of the tissue implant. A method includes providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant. The tissue patch is formed into a contracted state and inserted into a lumen containing the lesion. The tissue patch then is positioned in the vicinity of the lesion. After removing the protective liner to reveal the tissue implant, the tissue implant is placed in the lesion. | 12-18-2008 |
20090012627 | Double-structured tissue implant and a method for preparation and use thereof - A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment. | 01-08-2009 |
20090012628 | Method for use of a double-structured tissue implant for treatment of tissue defects - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. | 01-08-2009 |
20090012629 | COMPOSITIONS AND METHODS FOR TISSUE REPAIR - Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect. | 01-08-2009 |
20090024224 | Implantation of cartilage - The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect. | 01-22-2009 |
20090024225 | Implant for Targeting Therapeutic Procedure - An implantable device has a body that is substantially rigid and has a predetermined shape. The body is further bioabsorbable and has a density less than or equal to about 1.03 g/cc. When the device is implanted in a resected cavity in soft tissue, it causes the cavity to conform to the predetermined shape. The implantable device is further imageable due to its density being less than that of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined. | 01-22-2009 |
20090024226 | METHODS OF FORMING A TISSUE IMPLANT HAVING A TISSUE CONTACTING LAYER HELD UNDER COMPRESSION - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed. | 01-22-2009 |
20090024227 | METHODS OF FORMING A MULTILAYER TISSUE IMPLANT TO CREATE AN ACCORDION EFFECT ON THE OUTER LAYER - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed. | 01-22-2009 |
20090024228 | TISSUE IMPLANT HAVING A BIASED LAYER AND COMPLIANCE THAT SIMULATES TISSUE - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed. | 01-22-2009 |
20090030526 | COLLAGEN DEVICE AND METHOD OF PREPARING THE SAME - A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue. | 01-29-2009 |
20090030527 | AMORPHOUS METAL ALLOY MEDICAL DEVICES - This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. | 01-29-2009 |
20090036996 | Knit PTFE Articles and Mesh - Disclosed is a knitted article, and a method of producing such an article, having at least one PTFE fiber with oriented fibrils forming multiple fiber cross-over points wherein PTFE fiber is self-bonded in at least one of the cross-over points. | 02-05-2009 |
20090048684 | METHODS OF FORMING A MULTILAYER TISSUE IMPLANT HAVING A COMPLIANCE THAT SIMULATES TISSUE - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having an inner layer and an outer layer. A valve is provided for permitting the introduction of and retaining inflation media. At least one pull tab is provided on an end of the implant, to assist in positioning the implant. Kits and systems are also disclosed. | 02-19-2009 |
20090054994 | Methods and kits for prophylactically reinforcing degenerated spinal discs and facet joints near a surgically treated spinal section - A method is effective for prophylactically treating discs and facet joints near a spinal section that requires surgery. The method comprises the steps of performing a surgical procedure on a section of a spine, and reinforcing a disc or a facet joint adjacent to the surgically treated area with an effective amount of an injected, in situ curable biocompatible matrix or biocompatible polymeric compound. The procedure delays or prevents the development of permanent or irreversible degenerative changes in the treated disc and/or facet joint, thus offering the spinal surgery patient a higher probability of long-term success for arresting disc and facet joint degeneration and prevention of latent adjacent disc/facet joint problems. | 02-26-2009 |
20090054995 | Planar implant - A planar implant for replacement of biological tissues includes a layered structure including
| 02-26-2009 |
20090069902 | ARTIFICIAL CONTRACTILE TISSUE - Artificial contractile tissue including a structure (b,f) and several fibers (a,g) of variable length which are fixed at their ends to the structure (b,f). The fibers (a,g) are made of a contractile material which can be activated by an activator in such a way as to provide a tissue in a rest or in an activated position, the rest position being defined with non-rectilinear fibers (a,g) and the activated position being defined with fibers (a,g) of reduced length; the transition from the rest towards the activated position or vice-versa being defined by a fiber movement along a lateral direction which is perpendicular with respect to the fiber length. | 03-12-2009 |
20090069903 | Method For Improvement Of Differentiation Of Mesenchymal Stem Cells Using A Double-Structured Tissue Implant - A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. | 03-12-2009 |
20090069904 | BIOMATERIAL INCLUDING MICROPORES - A biomaterial including a designed pattern of micropores one at least one surface of the biomaterial is described. The micropores can be provided in a regular or irregular pattern, and can be either continuous or discontinuous. The biomaterial may be formed from a variety of materials, such as a biocompatible polymer or biocompatible tissue. The biomaterial including micropores on a surface may be used for a variety of medical applications such as tissue scaffolding, drug delivery, or tissue fixation. | 03-12-2009 |
20090099666 | Spongy implant - The invention relates to the use of a spongy material for the production of an implant ( | 04-16-2009 |
20090112332 | BONE GRAFT AND BONE GRAFT SUBSTITUTES WITH ANTIBIOTICS FOR SUSTAINED, LOCALIZED RELEASE OF ANTIBIOTICS FOR REDUCING POSTOPERATIVE SURGICAL WOUND INFECTION IN SPINAL AND OTHER BONE SURGERY - A bone graft or bone graft substitute material containing antibiotics is formed into crumbs, powder, putty, flexible sheets, or other form for localized delivery of drugs. The material is adapted to be placed inside a body for sustained, localized delivery of antibiotics. The antibiotics may be in a crystalline or non-crystalline form. | 04-30-2009 |
20090118838 | Materials Useful for Support and/or Replacement of Tissue and the Use Thereof for Making Prostheses - The invention relates to a material providing support and/or replacement of living tissues and the use thereof for manufacturing prostheses. The material according to the invention comprises microparticles of a biomaterial coated with polyelectrolyte multilayers containing one or more biologically active products. | 05-07-2009 |
20090138095 | Method for treating a cartilage defect, surgical instrumentation and surgical navigation system - The invention relates to a method for treating a cartilage defect by implanting a cartilage replacement implant through an arthroscopic access, comprising: determining at least one parameter for describing the arthroscopic access, providing a surgical instrumentation comprising at least two different applicator instruments for grasping the cartilage replacement implant, choosing one of the at least two applicator instruments of the instrumentation in dependence upon the at least one parameter determined for describing the arthroscopic access, and grasping and inserting the cartilage replacement implant into the patient's body with the chosen instrument through the arthroscopic access. | 05-28-2009 |
20090143867 | Implants and Methods for Repair, Replacement and Treatment of Disease - Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure. | 06-04-2009 |
20090157193 | Tendon and Ligament Repair Sheet and Methods of Use - Methods and device for treating or healing an injured tendon or ligament is disclosed. The device, a tendon and ligament repair sheet, has a porous layer and a denser layer, and optionally a therapeutic agent in the porous layer, the denser layer or both. The repair sheet is made from a resorbable or non-resorbable polymer. The repair sheet is securely attached to the injured tendon, ligament, muscle, or bone and has a suture pull out strength of at least 3N. If the injury involve severing of a ligament or tendon, one should place the severed ends in close proximity to each other and securely attach the repair sheet to both sides of the severed tendon or ligament at a distance from the injury so that the repair sheet remains securely attached to the tendon, ligament, muscle, or bone while the tissue is healing. | 06-18-2009 |
20090157194 | IMPLANT COMPOSITE MATERIAL - An implant composite material is provided which is for use in the treatment of articular cartilage disorders such as hip joint femur head necrosis and knee joint bone head necrosis, the reconstruction/fixing of a bio-derived or artificial ligament or tendon, the uniting/fixing of a bone, etc. Part of the implant composite material is replaced by bone tissues in an early stage to enable the material to stably bond with a living bone, while the other part retains a necessary strength over a necessary time period. Finally, the implant composite material is wholly replaced by the living bone and disappears. | 06-18-2009 |
20090187258 | Implant for Tissue Engineering - The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site. | 07-23-2009 |
20090204227 | Molecular enhancement of extracellular matrix and methods of use - A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect. | 08-13-2009 |
20090204228 | EXTRACELLULAR MATRIX COMPOSITE MATERIALS, AND MANUFACTURE AND USE THEREOF - Described are preferred extracellular matrix composites including a first extracellular matrix material having a second extracellular matrix material deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material. | 08-13-2009 |
20090216338 | SOFT TISSUE IMPLANTS AND METHODS FOR MAKING SAME - The present invention features soft tissue implants comprising major ( | 08-27-2009 |
20090240341 | TISSUE PROSTHESIS AND A METHOD OF, AND EQUIPMENT FOR, FORMING A TISSUE PROSTHESIS - A tissue prosthesis | 09-24-2009 |
20090240342 | PREFORMED SUPPORT DEVICE AND METHOD AND APPARATUS FOR MANUFACTURING THE SAME - A device for making a seamless, anatomically contoured, prosthetic device for supporting or maintaining the position of mammalian tissue, organ or structure or a replacement thereof, such as a breast implant, includes a support plate, an ironing plate or a clamping plate and a core plate, each of which is made from a thermally conductive material. The support plate and the ironing or clamping plates have openings formed through the thickness thereof. The core plate has a core extending outwardly from a lower surface thereof which is received through the openings in the ironing or clamping plate and the support plate. | 09-24-2009 |
20090240343 | INFLATABLE HERNIA PATCH - A patch for repairing an intra-abdominal defect is disclosed in one embodiment of the present invention as including a mesh layer providing a grid of material perforated by apertures through the mesh. This mesh is used to reinforce an area around an intra-abdominal defect. A containment layer is secured proximate an edge of the mesh layer. A filler is distributed across the apertures of the mesh to contain a fluid from passing through the mesh. The mesh layer, containment layer, and filler are connected to form a chamber to selectively expand upon receipt of a quantity of fluid between the containment layer and the filler. | 09-24-2009 |
20090270999 | PATCH FOR ENDOSCOPIC REPAIR OF HERNIAS - In some embodiments, a method of repairing a hernia may include one or more of the following steps: (a) introducing a patch prosthesis into a patient, (b) positioning the patch prosthesis over the hernia, (c) removing a wire frame from the patch prosthesis and the patient, (d) wrapping the patch prosthesis, (e) allowing the patch prosthesis to unwrap, (f) removing a removable stitch coupling the wire frame and a prosthetic fabric, and (g) securing the prosthetic fabric to the patient. | 10-29-2009 |
20090276056 | RESORBABLE CERAMICS WITH CONTROLLED STRENGTH LOSS RATES - Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled stregthloss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn | 11-05-2009 |
20090276057 | DOUBLE LAYER SURGICAL PROSTHESIS TO REPAIR SOFT TISSUE - A prosthesis for the treatment of hernias and/or laparoceles via an intraperitoneal route, having a mesh of filaments of non-resorbable and biocompatible polymer material having interstices permitting tissue growth and a sheet of polymer material having barrier properties and low adhesion to sensitive organs and tissues. The sheet is superimposed upon and joined to the mesh so as to form a stratified structure. In particular, the sheet is joined to mesh through a plurality of filaments located alongside each other at a spacing of not more than 5 mm. Each filament has a plurality of attachment sites to the mesh which are not more than 15 mm apart, and each length of filament between two successive attachment sites projects from the surface of the mesh facing sheet and is fused to the sheet. | 11-05-2009 |
20090287313 | TISSUE ADHESIVE SEALANT - A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1. | 11-19-2009 |
20090306790 | Elastase Treatment of Tissue Matrices - A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time. | 12-10-2009 |
20090312842 | Assembled Cartilage Repair Graft - Bifunctional and assembled implants are provided for osteochondral implantation. | 12-17-2009 |
20090312843 | Tissue Reconstruction Devices and Methods - The present invention provides an implantable prosthesis comprising a viscera separating barrier that defines a shell having a pocket with an opening that receives an insert. It is contemplated that the insert comprises at least one of an absorbable mesh, a non-absorbable mesh, or an absorbable and non-absorbable mesh combination inserted into the pocket through the opening. In preferred embodiments the viscera separating barrier is acellular collagen, and the absorbable mesh is selected from at least one of a polyglactin, a polyglycolic acid, a polyglactin and a polylactic acid, and the non-absorbable mesh comprises a polypropylene mesh. It is contemplated that the viscera separating barrier acts to reduce or even eliminate attachment of viscera to the prosthesis to encourage rapid cell penetration and revascularization; the non-absorbable mesh will provide immediate, reliable in-growth; and the absorbable mesh will give stability to the prosthesis. | 12-17-2009 |
20100016989 | METAL OXIDE SCAFFOLDS - The present invention relates to a metal oxide scaffold comprising titanium oxide. The scaffolds of the invention are useful for implantation into a subject for tissue regeneration and for providing a framework for cell growth and stabilization to the regenerating tissue. The invention also relates to methods for producing such metal oxide scaffolds and their uses. | 01-21-2010 |
20100023132 | SYSTEM AND METHOD FOR SCAFFOLDING ANASTOMOSES - Embodiments of the invention provide systems and methods for using a tissue scaffold to facilitate healing of an anastomosis. One embodiment provides a tissue scaffold for placement at an anastomotic site within a body lumen comprising a radially expandable scaffold structure having lateral and mid portions, at least one retention element coupled to each lateral portion and a barrier layer. The retention element engages a luminal wall when the scaffold structure is expanded to retain the structure and exert a compressive force on the anastomosis. The mid portion has a greater radial stiffness than the lateral portions such that when the structure is expanded, the lateral portions engage tissue prior to the mid portion. The barrier layer is configured to engage a luminal wall when the structure is expanded to provide a fluidic seal at the anastomosis. The barrier layer may also include releasable biological agents to promote anastomotic healing. | 01-28-2010 |
20100030340 | Plasticized Grafts and Methods of Making and Using Same - The invention provides a plasticized tissue or organ that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in natural tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the plasticized bone or soft tissue product can be placed directly into an implant site without significant preparation in the operating room. | 02-04-2010 |
20100057218 | METHODS OF ADMINISTERING A MATERIAL INTO A PATIENT FOR DERMAL ENHANCEMENT - The present invention is directed to methods of administering a material to a patient for dermal enhancement and/or as soft tissue fillers. The invention also relates to double-gloved methods of molding such a material after administration to a patient to achieve a desired orientation of the material in the patient. The invention also relates to the use of certain materials, including polylactic acid, hyaluronic acid, hydrogel, and/or collagen or other suitable materials for the preparation of a pharmaceutical composition for dermal enhancement and/or as soft tissue filler. The invention further relates to kits or packages that include a material for dermal enhancement and/or soft tissue filler and instructions as to how dermal enhancement or the filling of soft tissue is achieved. | 03-04-2010 |
20100063599 | DEVICE FOR SOFT TISSUE REPAIR OR REPLACEMENT - Disclosed are composite implantable tissue attachment devices comprising a mechanical reinforcing component and a cellular scaffold component. Disclosed devices include a wide, relatively flat portion for supporting long term repair of tissue. Disclosed devices can include a tapered portion at the end of the wide portions that can lead into a narrower elongated extension for aiding in placement of the device during a surgical procedure. The wide portion of the device can provide tensile strength along the longitudinal axis of the device as well as porosity. The wide devices can cover a larger surface area of a delivery site than standard suture. Disclosed materials can be utilized in, e.g., soft tissue repair such as tendon and ligament reconstruction and repair. | 03-11-2010 |
20100063600 | Materials and Methods for Soft Tissue Augmentation - The subject invention provides materials and methods for soft tissue augmentation. The materials and methods of the subject invention can, advantageously, be used to correct defects such as velopharyngeal insufficiency after cleft palate repair. Other uses include treatments for gastroesophageal acid-reflux, urinary incontinence, wrinkles and contour abnormalities. | 03-11-2010 |
20100082113 | TISSUE REPAIR IMPLANT - Described herein are tissue repair implants that include a first or lower layer of peritoneal membrane and a support member. The implants can further include an upper layer of peritoneal membrane, and the support member can reinforce the two layers of peritoneal membrane. For example, the support member can be located between the lower layer of peritoneal membrane and the upper layer of peritoneal membrane. The support member can be encapsulated between the two layers of peritoneal membrane to attach the two layers of peritoneal membrane to the support member. The support member can be made from a non-biological synthetic material mesh with a plurality of openings extending therethrough. Either of the layers of peritoneal membrane and/or the support member may be attached to a wall (e.g., an interior wall) of an abdominal tissue. Either of the layers of peritoneal membrane may be remodelled by in-growth of tissue. | 04-01-2010 |
20100114328 | RESORBABLE MEMBRANE IMPLANTING METHODS FOR REDUCING ADHESIONS - A resorbable thin membrane is applied over a treatment site before a treatment is applied over the resorbable thin membrane to the site. In a particular implementation, a resorbable thin membrane is adhesively applied over a treatment site of tissue before a treatment is conducted onto the tissue whereby the treatment is performed through the resorbable thin membrane. The treatment can be an incision that is made through both the resorbable membrane and into or through the tissue. | 05-06-2010 |
20100145473 | Gradient Template for Angiogensis During Large Organ Regeneration - This invention relates to highly porous scaffolding and methods of producing the same. Specifically, the scaffolding comprises a pore volume fraction of no less than 80% (v/v) of the total volume of the scaffold and interconnecting pores forming channels in the scaffold. | 06-10-2010 |
20100168869 | Tissue integration implant - The present invention relates to a tissue defect repair implant including a porous material, wherein the material is expandable or compressible. The implant may be a scaffold, and may also be formed of a material such as, for example, collagen or demineralized bone matrix. Another aspect of the invention may be a method for the repair of a tissue defect in a patient in need thereof, including implanting an implant between two adjacent tissues, wherein the implant may include a porous material which is expandable or compressible. The two tissues may be soft tissue and hard tissue, and alternatively, the two tissues may be soft tissue, and may further be the same or different soft tissues. | 07-01-2010 |
20100168870 | SYSTEM FOR PROVIDING FLUID FLOW TO NERVE TISSUES - An apparatus and system for providing reduced pressure to a defect in a nerve is disclosed. The apparatus comprises a nerve conduit having a generally tubular shape that has walls including a luminal wall surrounding the tissue site to contain fluids within a luminal space between the tissue site to contain fluids within a luminal space between the tissue site and the luminal wall. The apparatus further comprises a manifold having a porous body and a connector for receiving reduced pressure, wherein the manifold is positioned within the luminal space adjacent the tissue site to distribute the reduced pressure to the defect. Additionally, a method for providing reduced pressure to a defect in a nerve is disclosed that includes implanting the nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue. | 07-01-2010 |
20100168871 | ARTIFICIAL DURA BIOMEDICAL DEVICE AND BRAIN SURGERY METHOD UTILIZING THE SAME - An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura. | 07-01-2010 |
20100168872 | BIOMATERIAL SCAFFOLDS FOR CONTROLLED TISSUE GROWTH - This invention relates to biomaterials for directional tissue growth which comprise soluble fibres having a variable cross-sectional area which dissolve in a directional manner in situ, thereby controlling the direction and rate of formation of microchannels within the biomaterial and allowing vectored and timed channelling through the biomaterial. This may be useful, for example in directing the growth of blood vessels, nerves and other repair cells through the biomaterial in defined directions. | 07-01-2010 |
20100179667 | SCAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALS - A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold. | 07-15-2010 |
20100204803 | ARTIFICIAL CONTRACTILE STRUCTURE AND APPARATUS COMPRISING SUCH STRUCTURE - An artificial contractile structure generally devised to be used in the medical field to assist the functioning of an organ, includes a support ( | 08-12-2010 |
20100217403 | SWELLABLE HYALURONIC ACID PARTICLES - The present invention generally relates to particles comprising hyaluronic acid, wherein the particles are coated or encapsulated with a coating. The coating preferably comprises a polymer, protein, polysaccharide, or combination thereof that decreases the rate of degradation of the hyaluronic acid once the particles are placed in an aqueous environment, such as inside mammalian skin. The compositions of the present invention comprising such coated hyaluronic acid are useful for soft tissue augmentation, and are particularly useful as dermal fillers. | 08-26-2010 |
20100228359 | IMPLANT OF CROSS-LINKED SPIDER SILK THREADS - The present invention provides the use of spider silk threads for the production of tissue implants for medical use. A scaffolding matrix is provided for implantation, which matrix is comprised of spider silk thread and/or segments of spider silk threads which are cross-linked. The cross-linked spider silk thread segments essentially maintain a three-dimensional shape into which it is formed by pressing between moulds. The three-dimensional shape obtainable by moulding is sufficiently stable to be used as an implant or for colonizing by mammalian cells while essentially maintaining the three-dimensional shape. In a further embodiment, the scaffolding matrix of cross-linked spider silk segments is at least partially covered by cells autologous or heterologous to the implant recipient. The matrix colonized with cells is obtainable by in vitro cultivation of isolated cells in suspension with the scaffolding matrix. | 09-09-2010 |
20100249946 | TRANSCUTANEOUSLY ADJUSTABLE FLUID-FILLED IMPLANTS - Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having a self-sealing membrane operably attached to a wall of the implant. The self-sealing membrane provides access for filling the device, and includes a first layer comprising a fabric. The fabric has a first plurality of yarn strands positioned in a first direction, and a second plurality of yarn strands positioned in a second direction. The first and second plurality of yarn strands intersect to form a matrix pattern with cells defined by free spaces between yarn strands. The membrane also includes a first elastomeric material configured to fill the cells as well as form a coating over the first and second plurality of yarn strand, and a second layer comprising a second elastomeric material. The second elastomeric material has a lower durometer than the first elastomeric material. Kits and systems are also disclosed. | 09-30-2010 |
20100274362 | Cartilage particle tissue mixtures optionally combined with a cancellous construct - Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143. | 10-28-2010 |
20100280627 | DISSECTION AND RETRACTION DEVICE FOR VAGINAL SACRAL COLPOPEXY - In one embodiment the apparatus includes a first retractor, a second retractor, and a shaft. The shaft defines a central channel extending from a first end portion of the shaft to a second end portion of the shaft. The first retractor and the second retractor are configured to collectively form a lumen. The shaft is configured to be disposed within the lumen. In one embodiment method of disposing a graft within a body of a patient, includes making an incision in the body of the patient, inserting a medical device into the body of the patient through the incision, removing the shaft of the medical device from the body of the patient, and moving the first refractor within the body of the patient away from the second retractor. | 11-04-2010 |
20100286795 | Stable Cartilage Defect Repair Plug - An apparatus and method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone. | 11-11-2010 |
20100298953 | DEVICE AND METHOD FOR POSITIONING A SURGICAL PROSTHESIS - In one aspect, the present invention relates to a medical device for positioning a surgical prosthesis on a fascial defect of a tissue wall. In one embodiment, the medical device has a removable flexible member having a body portion having at least one magnetic section, and a magnet member positioned in relation to the at least one magnetic section such that a movement of the magnet member causes the flexible member to move accordingly. The surgical prosthesis is detachably attachable to the flexible member, and the flexible member is introducible into and removable from a body cavity. | 11-25-2010 |
20100312357 | DEVICE AND METHOD FOR DEPLOYING AND ATTACHING AN IMPLANT TO A BIOLOGICAL TISSUE - This present invention generally relates to devices and methods for repairing an aperture in a biological tissue. In certain embodiments, the invention provides a system for closing an aperture in a biological tissue including a handle, an elongate shaft connected to the handle, and a deployment scaffold connected to the shaft, in which the scaffold is configured to releasably retain a surgical implant and the scaffold is configured to deploy and attach the surgical implant to the biological tissue. | 12-09-2010 |
20100312358 | Implantable Repair Device - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries. | 12-09-2010 |
20100324697 | System and method for a piezoelectric scaffold for nerve growth and repair - Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure. | 12-23-2010 |
20110015759 | ADHERING COMPOSITION AND METHOD OF APPLYING THE SAME - A method of in-situ adhering including providing pre-gel including phenolic compound and water miscible polymers like carbohydrates, salts of anionic polysaccharide, spreading layer of pre-gel onto a surface, adding solid support, comprising cross linking agents capable of interacting with the polymer, to pre-gel, and allowing pre-gel to cure and adhere onto surface. | 01-20-2011 |
20110015760 | IMPLANTABLE PROSTHESIS - A prosthetic device including biologically compatible and preferably fully resorbable materials includes a tissue infiltratable portion and a second portion. The two portion may have different rates of resorption. The ingrowth portion may include a plurality of openings to encourage tissue ingrowth and vascularization. The second portion may be stronger than the ingrowth portion and provide a location for fixation of the device. The portion may be attached using resorbable adhesives, sutures or other constructs to render a fully resorbable prosthesis. | 01-20-2011 |
20110035024 | Self-Supporting Collagen Tunnel for Guided Tissue Regeneration and Method of Using Same - A biocompatible, self-supporting, curved, collagen membrane adapted to be secured by bone tacks or bone screws over exposed bone at a desired bone graft site in the alveolar ridge of a patient such that the membrane defines a space having a predetermined height and width over the exposed bone, in which the membrane maintains its structural integrity for at least 4 months after implantation at the bone graft site and then naturally breaks down and is resorbed by the patient's body, a method of making such a membrane, and a method of using such a membrane for vertical augmentation of the alveolar ridge of the patient. | 02-10-2011 |
20110035025 | OSTEOCHONDRAL IMPLANT PROCEDURE - A surgical procedure for preparing a damaged area of a human knee to receive at least one graft, according to which a moldable material is positioned over the damaged area and removed after it hardens. The mold is used as a template to determine the number and/or a dimension of the openings to be formed in the damaged area for receiving corresponding grafts. | 02-10-2011 |
20110054633 | Nanofilm Protective and Release Matrices - A modified atomic plasma deposition (APD) procedure is used to produce amorphous, nonconformal thin metal film coatings on a variety of substrates. The films are porous, mesh-like lattices with imperfections such as pinholes and pores, which are useful as scaffolds for cell attachment, controlled release of bioactive agents and protective coatings. | 03-03-2011 |
20110060420 | PTFE COMPOSITE MULTI-LAYER MATERIAL - A composite multi-layer material may generally comprise a d-PTFE material combined with an open structured material (either resorbable or non-resorbable) creating a composite multi-layer material. Attachment of the layers may be accomplished by stitching layers of material, exertion of hydraulic or other pressure, application of a biocompatible adhesive or heat, or some combination of the foregoing. Use of a d-PTFE, unexpanded material has multiple alternative uses, including without limitation, placement on the visceral side of a hernia that may minimize or even eliminate the incidence of abdominal adhesions. Alternatively, the material may be used to create tubing sufficient as a graft for treating abdominal aortic aneurysms. | 03-10-2011 |
20110082564 | Devices and Methods for Tissue Engineering - A tissue scaffold fabricated from bioinert fiber forms a rigid three-dimensional porous matrix having a bioinert composition. Porosity in the form of interconnected pore space is provided by the space between the bioinert fiber in the porous matrix. Strength of the porous matrix is provided by bioinert fiber fused and bonded into the rigid three-dimensional matrix having a specific pore size and pore size distribution. The tissue scaffold supports tissue in-growth to provide osteoconductivity as a tissue scaffold, used for the repair of damaged and/or diseased bone tissue. | 04-07-2011 |
20110082565 | NONWOVEN STRUCTURE AND METHOD OF FABRICATING THE SAME - A method for fabricating a nonwoven structure is disclosed. The method comprises: forming a nonwoven layer of polymer fibers on the collector liquid surface, transferring the layer to a solid surface, and repeating the formation and the transfer in a layerwise manner. The method is generally effected by spinning liquefied polymer, in particular by employing electrostatic or hydrostatic forces. The nonwoven structure formed comprises of plurality of nonwoven layers: the average thickness of the nonwoven structure is at least 0.5 mm and the structure has an overall porosity of at least 90%. The nonwoven structure an be used in forming a scaffold for tissue engineering, in particular a cell-scaffold composition, suitable for implanting in a patient, wherein at least one cell population is seeded on at least one of the plurality of layers. | 04-07-2011 |
20110087338 | Use of Epineural Sheath Grafts for Neural Regeneration and Protection - Described herein is conduit material that causes minimal inflammatory reaction, and serves as a structural guide for regenerating nerve tissue (e.g., axons). Thus, the invention is directed to methods of treating a nerve injury in an individual in need thereof. The methods employ an isolated, naturally occurring epineural sheath, and can be used, for example, to regenerate nerve tissue in an individual in need thereof. Also provided herein is a device for harvesting an epineural sheath. | 04-14-2011 |
20110093088 | SELF DEPLOYING IMPLANT IN NEEDLE - Described, in certain inventive embodiments, are unique devices and methods for introducing implants into soft tissue of a patient. One of these devices includes a tissue-penetrating member that is configured to pass in its entirety through a volume of patient tissue. The tissue-penetrating member has a leading end and a trailing end, and provides a receiving space for receipt of an implant body portion for carrying the implant body portion into the volume of patient tissue. The device also includes an implant that has an implant body portion removably received in the receiving space of the tissue-penetrating member. The implant body portion is configured for deployment from the receiving space in the volume of patient tissue so as to remain deployed there along a passageway traversed by the tissue-penetrating member. | 04-21-2011 |
20110098826 | Disc-Like Angle-Ply Structures for Intervertebral Disc Tissue Engineering and Replacement - Provided are implant scaffolds comprising angle-ply arrays of two or more layers of substantially aligned fiber, methods of making and using said scaffolds, and kits comprising such scaffolds. | 04-28-2011 |
20110112655 | DEVICE FOR REGENERATION OF ARTICULAR CARTILAGE AND OTHER TISSUE - An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure. | 05-12-2011 |
20110125287 | Reinforced Tissue Patch - A method of improving the mechanical properties of a tissue patch is provided. The method includes the steps of providing a tissue patch and placing at least one barbed suture along at least a portion of the tissue patch. The method may further include the step of placing one or more additional barbed sutures in a laterally spaced relation to the barbed suture. The barbed suture may be biodegradable or non-biodegradable. | 05-26-2011 |
20110125288 | Tissue Augmentation Material And Method - A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted. | 05-26-2011 |
20110125289 | Implantable Graft to Close a Fistula - An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided. | 05-26-2011 |
20110144767 | DEVICES AND METHODS FOR TREATING DEFECTS IN THE TISSUE OF A LIVING BEING - An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass. | 06-16-2011 |
20110166673 | QUILTED IMPLANTABLE GRAFT - Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members. | 07-07-2011 |
20110172785 | COMPLIANT COMPOSITES FOR APPLICATION OF DRUG-ELUTING COATINGS TO TISSUE SURFACES - A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further comprises a barrier layer for localized delivery of the bioactive agent. | 07-14-2011 |
20110172786 | Implantable Repair Device - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries. | 07-14-2011 |
20110178608 | Implantable Repair Device - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries. | 07-21-2011 |
20110184530 | High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair - This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes. | 07-28-2011 |
20110184531 | OPEN CELLED FOAMS, IMPLANTS INCLUDING THEM AND PROCESSES FOR MAKING SAME - Described herein are open celled foams including a matrix of interconnected spheres. Also described herein are methods of making open celled foams as well as making composite members with open celled foam coatings covering at least a portion of the composite member. The open celled foams described herein are silicone based materials and can be used to coat implants such as breast implants and function to encourage tissue ingrowth and reduce capsular formation. | 07-28-2011 |
20110196508 | CARTILAGE REPAIR MIXTURE CONTAINING ALLOGRAFT CHONDROCYTES - The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×10 | 08-11-2011 |
20110202142 | BIOLOGICALLY DERIVED COMPOSITE TISSUE ENGINEERING - The present application is directed to engineering of tissues, especially composite tissues such as a joint. Various aspects of the application provide tissue modules and methods of fabrication and use thereof. Some embodiments provide a tissue module that can be fabricated to be substantially similar in anatomic internal and external shape as a target tissue. Some embodiments provide a composite tissue module having a plurality of layers, each of which simulate a different tissue (e.g., bone and cartilage of a joint). | 08-18-2011 |
20110208320 | ABDOMINAL WALL TREATMENT DEVICES - Devices and methods for treating or repairing openings in an body wall are provided. The devices and methods can include acellular tissue matrices. The tissue matrices can be positioned within the abdominal opening and can be used to close the opening. | 08-25-2011 |
20110213470 | METHODS FOR USING A THREE-DIMENSIONAL STROMAL TISSUE TO PROMOTE ANGIOGENESIS - The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue. | 09-01-2011 |
20110218647 | MEDICAL IMPLANT - A cartilage plug ( | 09-08-2011 |
20110224801 | SEMI-PERMEABLE MEMBRANES FOR USE IN SURGICAL REPAIRS - A semi-permeable membrane can be used to promote the surgical repair of cartilage in a damaged or diseased joint, such as a knee, hip, or shoulder. In one method, the semi-permeable membrane is secured to the “articulating” surface (the exposed surface, as opposed to the “anchoring” surface which rests on a condyle) of a resorbable fibrous matrix that has been seeded, before implantation, with chondrocyte or similar cells that generate cartilage. A membrane used in this manner can help protect the cells as they grow, reproduce, and secrete new cartilage inside the resorbable matrix. In another method, the semi-permeable membrane is secured to a slightly damaged surface of a cartilage segment that is suffering from a condition known as chondromalacia, without using an underlying implanted matrix or other device. In a slightly different use, a semi-permeable membrane as disclosed herein can be used in conjunction with a cell-growing scaffold that is being used to generate tissue to repair or supplement an internal organ, such as a liver, spleen, pancreas, or possibly a heart | 09-15-2011 |
20110238186 | PREPARATION OF REGENERATIVE TISSUE SCAFFOLDS - Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response. | 09-29-2011 |
20110245929 | METHODS AND COMPOSITIONS FOR JOINT HEALING AND REPAIR - The invention in some aspects provides implantable articles comprising in vitro-prepared tissues for joint repair. Devices and methods for introducing implantable articles into a subject are also provided. In some aspects of the invention devices and systems for minimally invasive surgery are provided. In some aspects, methods are provided for regenerating a bone-tendon interface in a subject by implanting an in vitro-prepared tissue between a detached tendon or detached ligament and a bone in a subject. In other aspects, methods are provided for maintaining exogenous, viable fibroblasts between a detached tendon and a bone in a subject. In other aspects, methods are provided for delivering exogenous cytokines and/or growth factors to a damaged bone-tendon interface. | 10-06-2011 |
20110251699 | AUTO-SEALANT MATRIX FOR TISSUE REPAIR - Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids. | 10-13-2011 |
20110257761 | PROSTHETIC DEVICE HAVING REGIONS OF VARYING STRETCH AND METHOD OF MANUFACTURING THE SAME - A biocompatible surgical scaffold made from a multi-filament silk yarn for soft tissue reconstruction. The scaffold incorporates regions of varying stretch having different physical and mechanical properties that allow contouring to the required soft tissue shape to be replaced or repaired. The porous structure allows tissue in-growth, while the mesh degrades at a rate which allows for a smooth transfer of mechanical properties to the new tissue from the silk scaffold. | 10-20-2011 |
20110257762 | PROSTHETIC IMPLANT WITH A DELAYED BONDING EFFECT - The invention relates to a prosthetic system ( | 10-20-2011 |
20110257763 | Method for Bone-filling Cartilage Tissue for Inducing Regeneration of the Cartilage - It is intended to provide a medical material which enables a new method for cartilage tissue regeneration treatment based on an entirely new concept unlike a treatment method by transplantation of autologous cartilage tissue, a cartilage alternative or undifferentiated cells. The invention provides a bone filler for cartilage tissue regeneration comprising hydrogel having an interpenetrating network structure formed by two or more crosslinked network polymers or a semi-interpenetrating network structure formed by a crosslinked network polymer and a linear polymer. By filling the bone filler of the invention in a hole or a groove provided in subchondral bone just under damaged cartilage tissue, regeneration of the cartilage tissue or both the cartilage tissue and the subchondral bone can be promoted. | 10-20-2011 |
20110264235 | ELECTROSTATIC-ASSISTED FIBER SPINNING METHOD AND PRODUCTION OF HIGHLY ALIGNED AND PACKED HOLLOW FIBER ASSEMBLY AND MEMBRANE - The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/−10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications. | 10-27-2011 |
20110264236 | ENGINEERED CRANIOFACIAL CONSTRUCTS WITH COMPOSITE SCAFFOLD - The present invention provides for compositions and constructs for craniofacial reconstruction implants, and methods for making and using same. Specific embodiments provide for a biocompatible scaffold having an auricular shape and a permanent bendable framework within the scaffold, wherein the permanent bendable framework allows deformation and return to pre-deformation shape, and thus maintains the auricular shape of the scaffold. | 10-27-2011 |
20110270411 | NERVE GRAFT PREPARED BY ELECTROSTATIC SPINNING, THE PREPARING METHOD AND THE SPECIAL APPARATUS USED THEREFOR - The present invention discloses an artificial nerve graft prepared by electrostatic spinning, the preparing method and a special apparatus used therefor. Said artificial nerve graft is in the shape of a tube composed of nano-fiber that is prepared by electrostatic spinning of a polymer. The materials used in the present invention are bio-degradable materials and of desirable biocompatibility with human body. The product of the present invention is free of exogenous toxic substances or substances having side effects. Furthermore, the tube wall is of a 3-dimensional structure having micropores contained therein thereby providing a path for supplying nutritions required for the growth of nerve cells. Another advantage of the present invention is that necessary induction and space are provided for the growth of the nerve cells. | 11-03-2011 |
20110270412 | FABRICATION OF A VASCULAR SYSTEM USING SACRIFICIAL STRUCTURES - The first aspect of the present invention is directed to a method of producing a vascular network preform (VNP). This method involves forming a network of elongate fibers and at least one elongate structure from a sacrificial material. The diameter of the elongate structure is greater than that of the elongate fibers. The network of elongate fibers is placed in contact with at least one elongate structure either following or during forming the network of elongate fibers or forming the at least one elongate structure. A matrix is applied around the network of elongate fibers, in contact with the at least one elongate structure. The network of elongate fibers and elongate structure, within the matrix is sacrificed to form a preform. The resulting preform contains a vascular network of fine diameter tubes in contact with at least one elongate passage having a diameter greater than that of the fine diameter tubes. The resulting solid preform and methods of using it are also disclosed. | 11-03-2011 |
20110301717 | Supporting and Forming Transitional Material for Use in Supporting Prosthesis Devices, Implants and to Provide Structure in a Human Body - A transitional mesh and thread for use in the human body is dissolved. The transitional mesh being comprised of sections of non-absorbable mesh fabric with sections of absorbable mesh fabric, such that each non-absorbable section is attached to absorbable mesh fabric. The non-absorbable mesh sections can be overlaid with absorbable mesh which after it is absorbed leaves the non-absorbable mesh in an array without connection to each other. The thread to be used to create the mesh has non-absorbable fibers that can be discontinuous, loosely woven or embedded in an absorbable material. The fabric mesh itself can be loosely woven and coated with absorbable material. The patterns of non-absorbable mesh and space between non-absorbable mesh sections can be varied to provide various strengths and degrees of motion and movement. The mesh can also be coated with materials to reduce infection, provide tissue growth, reduce scar tissue or other medicinal purposes. | 12-08-2011 |
20110307077 | COMPOSITE ANISOTROPIC TISSUE REINFORCING IMPLANTS HAVING ALIGNMENT MARKERS AND METHODS OF MANUFACTURING SAME - A composite implant includes an anisotropic surgical mesh having more stretchability along a first axis and less stretchability along a second axis that traverses the first axis, and an alignment marker overlying a first major surface of the anisotropic mesh and extending along the first axis. The implant includes a first absorbable, anti-adhesion film overlying the alignment marker and the first major surface of the anisotropic mesh, and a second absorbable, anti-adhesion film overlying the second major surface of the biocompatible mesh. The alignment marker is disposed between the first and second absorbable films and the first and second absorbable films are laminated to the anisotropic mesh. | 12-15-2011 |
20110313541 | METHODS FOR GENERATING CARTILAGE TISSUE - A hyaline-like, single layer cartilage tissue construct includes chondrogenic cells dispersed within an endogenously produced extracellular matrix. The single layer cartilage tissue construct has a glycosaminoglycan content substantially equal to the glycosaminoglycan content of native cartilage tissue. A method for generating a single layer cartilage tissue construct includes isolating a population of chondrogenic cells and then expanding the population of chondrogenic cells. Next, the population of chondrogenic cells is seeded into a bioreactor having a volume defined by oppositely disposed gas permeable membranes. The population of chondrogenic cells is then cultured in a serum-free culture medium for a time sufficient to permit the population of chondrogenic cells to differentiate and form the single layer cartilage tissue construct. | 12-22-2011 |
20110313542 | ENGINEERED BIOLOGICAL NERVE GRAFT, FABRICATION AND APPLICATION THEREOF - An engineered three-dimensional structure includes living cells cohered with each other. The living cells suitably include Schwann cells and at least one other type of cell. The cells accompanying the Schwann cells can suitably be bone marrow stem cells or another type of cell having one or more anti-inflammatory properties. The structure is suitably a graft that facilitates restorative axon growth when the graft is implanted between the proximal and distal stubs of a severed nerve in a living organism. The graft can optionally include a plurality of acellular conduits extending between opposite axial ends of the graft. Bio-printing techniques can be used to assemble a three-dimensional construct that becomes through maturation an axon-guiding graft, by stacking a plurality of multicellular bodies, each of which includes a plurality of living cells cohered to one another to sufficiently to avoid collapsing when the multicellular bodies are stacked to form the structure. | 12-22-2011 |
20110313543 | POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES - A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo. | 12-22-2011 |
20110320009 | MATRIX FOR TISSUE REPAIR - Implants include a porous layer made from a composition including a compound wherein collagen is cross-linked to a glycosaminoglycan, the porous layer being optionally joined to a collagen film. | 12-29-2011 |
20120010725 | Tissue Implants for Implantation and Methods for Preparing the Same - A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof. | 01-12-2012 |
20120010726 | Adhesion-Resistant Surgical Access, Reinforcement and Closure Prosthetic - Described are devices and methods for reinforcing a layer of living tissue, which when affixed to a tissue layer prior to surgical incision, reinforces the tissue to be incised, provides a fibro-conductive matrix to promote healing in a preferred plane, and provides for a subsequent closure and fluidic seal. A partially or entirely absorbable growth matrix is disclosed, comprising two adhesion-resistant layers enclosing a cellular conductive medium for promoting fibrosis in a preferred plane. The cellular conductive portion is partially or entirely sequestered from surrounding tissue. The device is constructed in a physiologic range of tensile strengths and elasticity suitable for closure of the pericardium, peritoneum, or other typically thin membranes enclosing organs in the body, whose function is to prevent adhesions between tissue surfaces normally in motion. | 01-12-2012 |
20120010727 | AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN SPORT INJURY SURGERIES - Improved methods for sport injury surgeries are described. The improvement includes covering a damaged site of fascia with at least one of an amniotic fluid and a construct for use in surgical repair of the sport injury prior to wound closing. The construct contains an allograft comprising at least one layer of human amnion and chorion tissues and the construct has a size and shape suitable for covering the damaged site of fascia. The method improves fascial membrane repair, reduces complications and recovery time of sport injury surgeries. | 01-12-2012 |
20120010728 | METHOD FOR SHAPING TISSUE MATRICES - Methods for shaping tissue matrices are provided. The methods can be used to produce shaped tissue products that retain desired biologic properties without using chemical crosslinking agents. | 01-12-2012 |
20120016491 | LAMINATE SHEET ARTICLES FOR TISSUE REGENERATION - The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue. | 01-19-2012 |
20120029653 | DEVICES AND METHODS FOR TREATING DEFECTS IN THE TISSUE OF A LIVING BEING - An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. | 02-02-2012 |
20120029654 | ARTIFICIAL DURA MATER AND MANUFACTURING METHOD THEREOF - Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents. | 02-02-2012 |
20120029655 | IMPLANTABLE XENOGRAFT PREPARED FROM A NON-HUMAN TISSUE PORTION - An implantable xenograft intended for human recipients for correcting cardiovascular abnormalities. The xenografts are prepared from a non-human native tissue portion and are completely sterilized, acellular and exhibit a tensile strength generally higher than that of the native tissue. The uniqueness of the xenografts is that the outer surface of the tissue portion is impregnated with collagen nano-fibers. The implantable xenograft exhibits excellent storage stability, non-immunogenicity, non-thrombogenicity, non-cytotoxicity and non-calcifying properties. | 02-02-2012 |
20120035743 | AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN MINIMALLY INVASIVE SURGERIES - A construct for use in a minimally invasive surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for insertion into a small incision or a cannula employed in the minimally invasive surgery for access to the surgical site. The allograft has a shape appropriate for covering the surgical site. Methods of preparing the construct and using it in a minimally invasive surgery are also described. The products and methods improve the performance of the minimally invasive surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection. | 02-09-2012 |
20120035744 | AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN JOINT REPAIR - A construct for use in a surgical repair of a damaged or inflamed joint is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for enclosing a damaged or inflamed joint or for covering or replacing a damaged or inflamed joint sheath during the surgical repair. Methods of preparing the construct and using it in a surgical repair of a damaged or inflamed joint are also described. The products and methods improve the performance of the joint surgery, e.g., by reducing inflammation, inhibiting fibrosis, scarring, fibroblast proliferation and post-operative infection while also promoting more rapid healing of damaged or traumatized joints. | 02-09-2012 |
20120059487 | BIOMATERIALS WITH ENHANCED PROPERTIES AND DEVICES MADE THEREFROM - Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are useful in the fabrication of biomedical devices, particularly those subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required. These enhanced properties can be attributed to elevated levels of elastin, altered collagen types, and other biochemical changes which contribute to these enhanced properties. Examples of devices which would be improved by use of such tissue include heart valves, including percutaneous heart valves, and vascular grafts, patches and the like. Such enhanced materials can be sourced from specific populations of animals, such as neonatal calves, or in range-fed adult cattle, or can be fabricated or created from cell populations exhibiting such properties. In one embodiment, glutaraldehyde-fixed neonatal pericardial tissue is used to create leaflets in a percutaneous heart valve, and may be used without chemical fixation, with or without processes to remove residual cellular membranes, and utilized as a scaffold material for tissue engineering. | 03-08-2012 |
20120059488 | TRANSPLANTATION DEVICE - The present invention is intended to provide a transplantation device which can transplant a graft into a layered tissue easily and without damaging the graft or a tissue around the transplantation site. A transplantation device ( | 03-08-2012 |
20120065741 | GUIDED TISSUE REGENERATION MEMBRANE - A guided tissue regeneration membrane has a top surface, a bottom surface and a plurality of through holes formed through the top and bottom surfaces. Each of the plurality of through holes has a base opening on the top surface and a tip opening on the bottom surface. The diameter of the base opening is larger than that of the tip opening. The guided tissue regeneration membrane is placed between a hard tissue and a soft tissue of gums with the top surface thereof facing the hard tissue so as to hinder the soft tissue from rapidly growing. The tip openings are available for the soft tissue to supply nutrient to the hard tissue therethrough. The hard tissue can grow from the base openings, through the corresponding through holes and to the soft tissue to repair periodontal tissue. | 03-15-2012 |
20120071988 | TISSUES PATCHES AND RELATED DELIVERY SYSTEMS AND METHODS - Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A system for delivering a tissue implant includes a catheter having an expandable member at a distal end portion, a carrier placed around the expandable member, and the carrier configured to expand from a contracted state to an expanded state and to receive the tissue implant. The tissue implant contacts the lesion of the alimentary tract when the expandable member expands the carrier to the expandable state. | 03-22-2012 |
20120078378 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane. | 03-29-2012 |
20120078379 | CELLULAR CONTROL AND TISSUE REGENERATION SYSTEMS AND METHODS - A system for in-vivo and ex-vivo tissue regeneration and cellular control, manipulation and management includes a source of cell manipulating factors, which are administered to a therapy zone via active pressure-differential components including a pump and a controller, or pulse-waves generated passively. A plate comprising tissue or an inert, bio-compatible material is provided in the therapy zone in proximity to a fluid flow manifold and tissue scaffolding. A tissue regeneration and cellular control method includes the steps of providing a cell manipulation factor source, providing one or more factors to a therapy zone and forming a pressure wave with a mechanical component or an in-vivo pressure wave source, such as the circulatory or lymphatic system. | 03-29-2012 |
20120083900 | MULTI-LAYER TISSUE SYSTEMS AND METHODS - Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch. | 04-05-2012 |
20120089237 | COMPOSITE AND ITS USE - The present invention relates to a composite comprising a structural part, a porous part, and at least two interconnecting parts arranged at a distance from each other and extending from the structural part to the porous part, thus connecting them to each other. The implant is characterised in that each interconnecting part is in the form of a band having a length, a width and a height, the width and the height both being independently at most 20% of the length of the band, and in that at least one of the interconnecting parts is at least partially embedded into the structural and porous parts. | 04-12-2012 |
20120089238 | INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS - A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described. | 04-12-2012 |
20120109335 | METHOD AND APPARATUS FOR RESTORING ARTICULAR CARTILAGE - The present invention comprises the provision and use of new and improved arthroscopic instrumentation for (i) harvesting a tissue biopsy from a non-critical section of a joint, and (ii) sizing and seating an autologous graft at an implant site. | 05-03-2012 |
20120123557 | DOUBLE CROSS-LINKAGE PROCESS TO ENHANCE POST-IMPLANTATION BIOPROSTHETIC TISSUE DURABILITY - Bioprosthetic tissues and methods for making same, comprising fixing bioprosthetic implant tissue by treatment with 0.1 to 10 wt. % glutaraldehyde at elevated temperature, capping said fixed tissue by treatment with a diamine crosslinking agent, and treating said capped tissue with about 0.6 wt. % glutaraldehyde. | 05-17-2012 |
20120143349 | BARBED SCAFFOLDS - A scaffold for tissue reinforcement according to embodiments of the present invention includes a plurality of barbs configured to engage the tissue. Such scaffolds may include braids with barbed fibers in the axial positions, braids with flexible barb strips in the axial positions, weaves with barbed fiber in the warp positions, weaves with flexible barb strips in the weft positions, and cerclages or other structures with barbs on one surface to lock the scaffold upon itself. Such barbs may be configured to substantially prevent sliding in one or more directions, depending upon an orientation of the barbs. Flexible tack strips may be biocompatible and/or resorbable. | 06-07-2012 |
20120150317 | NERVE GRAFT - A nerve graft includes a carbon nanotube film structure, a protein layer, and a nerve network. The protein layer is located on a surface of the carbon nanotube film structure. The nerve network is positioned on a surface of the protein layer and far away from the carbon nanotube film structure. | 06-14-2012 |
20120165957 | BIODEGRADABLE SCAFFOLD FOR SOFT TISSUE REGENERATION AND USE THEREOF - The present invention relates to new reinforced biodegradable scaffolds for soft tissue regeneration, as well as methods for support and for augmentation and regeneration of living tissue, wherein a reinforced biodegradable scaffold is used for the treatment of indications, where increased strength and stability is required besides the need for regeneration of living tissue within a patient. The present invention further relates to the use of scaffolds together with cells or tissue explants for soft tissue regeneration, such as in the treatment of a medical prolapse, such as rectal or pelvic organ prolapse, or hernia. | 06-28-2012 |
20120179271 | Devices and Methods for Tissue Engineering - A tissue engineering scaffold of interconnected and bonded fiber having a property with a value that is spatially distributed in at least two regions is provided. The scaffold has at least two regions with properties, such as porosity, strength, elastic modulus, osteoconductivity, and bioactivity that can be controlled and modified through fabrication processes that alter the pore size, pore size distribution, composition, and bonding of fiber and other additives. The value of the property can be provided with a gradient between each of the adjacent spatially distributed regions. | 07-12-2012 |
20120191216 | VOLUMETRIC GRAFTS FOR TREATMENT OF FISTULAE AND RELATED METHODS AND SYSTEMS - Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa. | 07-26-2012 |
20120197414 | NERVE GRAFT - A nerve graft includes a carbon nanotube structure, a hydrophilic layer, and a nerve network. The hydrophilic layer having a polar surface is located on a surface of the carbon nanotube structure. The nerve network positioned on the polar surface of the hydrophilic layer includes a number of neurons connecting with each other. The nerve network has a polarity. The polar surface of the hydrophilic layer has a polarity attracted to the polarity of the nerve network. | 08-02-2012 |
20120209401 | METHODS AND APPARATUS FOR DELIVERING AND POSITIONING SHEET-LIKE MATERIALS - An implant delivery system for delivering a sheet-like implant is disclosed. The device includes an implant spreader assembly disposed proximate the distal end of a delivery shaft. The implant spreader assembly includes a first arm and a second arm. The arms are coupled to the delivery shaft such that the first arm and second arm are moveable between a closed position and an open position. When the first and second arms are in the closed position, the arms extend generally in the longitudinal direction. When pivoting to the open position the distal end of each arm travels in a generally transverse direction to spread a sheet-like implant. | 08-16-2012 |
20120209402 | Implant for Tissue Engineering - The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site. | 08-16-2012 |
20120209403 | VASCULARIZED TISSUE GRAFT - The present invention relates to improved methods for tissue engineering including tissue transplantation, augmentation and regeneration, and more particularly, a method for the generation of donor vascularized tissue suitable for use in tissue transplantation, augmentation and/or repair. The present invention enables the use of a support matrix in the generation of an anatomical construct comprising the donor vascular tissue. The support matrix may be devised such that it has dimensions of a size and shape adapted to simulate those of tissue to be transplanted, augmented and/or repaired. The methods and support matrix of the present invention may also find application as a means for delivering a desirable gene product to a subject. The method and support matrix of the present invention is conveniently made available in the form of a kit, for use in the field of tissue engineering. | 08-16-2012 |
20120215322 | ARTIFICIAL DURA BIOMEDICAL DEVICE AND BRAIN SURGERY METHOD UTILIZING THE SAME - An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura. | 08-23-2012 |
20120221118 | MATERIALS FOR SOFT AND HARD TISSUE REPAIR - Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention. | 08-30-2012 |
20120226363 | METHOD FOR MANUFACTURING A DEVICE FOR REGENERATING BIOLOGICAL TISSUES - A device for regenerating biological tissues, particularly for regenerating tissues of the peripheral nervous system, the respective manufacturing method and the instrument used in the method, the regeneration device comprising a hollow tubular structure based on biocompatible material and having a structural porosity in which the pores are oriented substantially radially with respect to its longitudinal axis so as to minimize the formation of scar tissue around the damaged site and allow the growth of the biological tissue inside the pores and inside the duct defined by the hollow tubular structure and facilitate the transport of nutrients. | 09-06-2012 |
20120239161 | AT LEAST PARTIALLY RESORBABLE RETICULATED ELASTOMERIC MATRIX ELEMENTS AND METHODS OF MAKING SAME - The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans. | 09-20-2012 |
20120245705 | METHODS AND DEVICES FOR CELLULAR TRANSPLANTATION - Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system configured for placement within the porous scaffold, and a seal configured to enclose a proximal opening in the porous scaffold. The device may further comprise a cell delivery device for delivering cells into the porous scaffold. The method of cell transplantation comprises a two step process. The device is incubated in the host body to form a vascularized collagen matrix around a plug positioned within the porous scaffold. The plug is then retracted from the porous scaffold, and cells are delivered into the vascularized space created within the porous scaffold. | 09-27-2012 |
20120245706 | MESH ENCLOSED TISSUE CONSTRUCTS - Described is a scaffold that is strong enough to resist forces that exist inside a body, while possessing biocompatible surfaces. The scaffold is formed of a layer of mesh (e.g., Stainless Steel or Nitinol) that is tightly enclosed by a multi-layer biological matrix. The biological matrix can include three layers, such a first layer (smooth muscle cells) formed directly on the metal mesh, a second layer (fibroblast/myofibroblast cells) formed on the first layer, and a third layer (endothelial cells) formed on the second layer. The scaffold can be formed to operate as a variety of tissues, such as a heart valve or a vascular graft. For example, the mesh and corresponding biological matrix can be formed as leaflets, such that the scaffold is operable as a tissue heart valve. | 09-27-2012 |
20120253472 | TISSUE REPAIR DEVICES OF RAPID THERAPEUTIC ABSORBENCY - Novel implantable tissue repair medical devices are disclosed. The devices have a central fabric member having anti-adhesion films on both opposed sides. The films have pores, and are arranged such that the pores on the opposed films are offset. The devices are useful in hernia repair procedures. | 10-04-2012 |
20120253473 | COMPOSITE MATRIX - The present invention relates to a composite matrix that includes a reinforcing textile portion having two surfaces coated over at least 90% of the respective surface areas thereof, by means of at least a first layer including at least one resorbable macro-molecule and having a collagen content of between 50 and 100 wt % relative to the total weight of the first layer; the invention also relates to a prosthesis including such a matrix and to a method for preparing said matrix. | 10-04-2012 |
20120259428 | Soft Tissue Implant and Method of Using Same - A soft tissue implant for correction of temporalis depressions or hollowing. The implant has a symmetric shape or external configuration, so that the device may be used as either a right or left temporalis implant. The implant may lie under or on top of the remaining temporalis muscle, or in the location formerly occupied by the temporalis muscle, to correct post-craniectomy temporal hollowing. The implant is manufactured from a medical grade, long term implantable silicone polymer material. The implant has a shell which forms the base of the device, with the base having an exterior surface and an interior surface with spaced projecting support structures. The implant is fully flexible or bendable. | 10-11-2012 |
20120271432 | METHODS AND DEVICES FOR DELIVERING AND AFFIXING TISSUE SCAFFOLDS - Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism. | 10-25-2012 |
20120283843 | SYNTHETIC SEROUS MEMBRANES AND METHODS FOR MAKING THE SAME - The present disclosure relates to casting-mold imprints and synthetic reproductions of serous membranes for tissue engineering and organogenesis. The imprints and synthetic membranes disclosed herein may be composed of distinct biocompatible polymers, which provide a mechanism for separation. Further disclosed herein are methods for making imprints and synthetic membranes that mimic natural scrous membranes. | 11-08-2012 |
20120296442 | SYSTEMS AND METHODS FOR INTRA-OPERATIVE PHYSIOLOGICAL FUNCTIONAL STIMULATION - Improved assemblies, systems, and methods provide safeguarding against tissue injury during surgical procedures and/or identify nerve damage occurring prior to surgery and/or verify range of motion or attributes of muscle contraction during reconstructive surgery. Embodiments of methods according to the present invention provide the ability to intra-operatively simulate post-operative physiologic function of a body part. Such methods may be used during various surgical procedures, including nerve transfer procedures. Included are one or more steps of confirming paralysis or a weakened condition of a body part, confirming responsivity or operability of transfer tissue to supplement the functionality of the paralyzed or weakened part, and intra-operatively simulating post-operative functionality of the transfer tissue to enhance and/or predict the outcome of the surgical procedure. | 11-22-2012 |
20120296443 | SERICIN EXTRACTED FABRICS - Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties. | 11-22-2012 |
20120310367 | ADIPOSE TISSUE MATRICES - The present disclosure provides tissue products produced from adipose tissues, as well as methods for producing such tissue products. The tissue products can include acellular extracellular matrices. In addition, the present disclosure provides systems and methods for using such products. | 12-06-2012 |
20130006383 | Randomly Oriented, FGF-2-Modified Nanofiber Device for Use in Spinal Cord Repair - The invention relates to a device composed of a plurality of strips of randomly oriented nanofibers, wherein said strips are arranged along their longitudinal axes. In addition, the surface of the device's nanofibers are covalently modified with fibroblast growth factor-2. A method for using the instant device for facilitating axonal regeneration in spinal cord injury is also provided. | 01-03-2013 |
20130006384 | CULTURE MEDIUM, GRAFT, AND MANUFACTURING METHOD THEREOF - A graft includes a carbon nanotube structure and a biological tissue. The carbon nanotube structure has a polar surface. The polar surface is formed by treating the carbon nanotube structure with polarization. The biological tissue is adhered on the polar surface. In addition, a method for manufacturing a graft is also provided. | 01-03-2013 |
20130024004 | METHOD AND SYSTEM FOR STERILIZING OR DISINFECTING BY THE APPLICATION OF BEAM TECHNOLOGY AND BIOLOGICAL MATERIALS TREATED THEREBY - A method of disinfecting a biological material provides disposing at least a portion of the biological material in the path of the gas cluster ion beam or in the path of the accelerated neutral beam so as to irradiate at least a portion of the biological material to disinfect the irradiated portion. | 01-24-2013 |
20130024005 | COMPOSITE IMPLANT - An implant includes a biocompatible framework material and a biologically-active material. The biologically-active material is embedded in the biocompatible framework material, and a portion of the biologically-active material is exposed to the outside of the implant. | 01-24-2013 |
20130030548 | Engineered Tissue Implants And Methods Of Use Thereof - A engineered tissue implant comprising a perfusion chamber formed with a biocompatible flexible tubular member having a wall defining an internal fluid flow passage and a porous scaffold within the fluid flow passage of the tubular member, the porous scaffold arranged such that, in a presence of a perfusion fluid, the perfusion fluid will flow through the porous scaffold and be inhibited from flow between the porous scaffold and the wall of the tubular member. The engineered tissue implant may be understood as a transplantable cell construct or as an implantable bioreactor for cell growth both in vitro and/or in vivo. A method to provide tissue for reconstruction may comprise forming the engineered tissue implant containing a scaffold, introducing and seeding cells to the scaffold, introducing a perfusion fluid to the scaffold which flows through the fluid flow passage and scaffold, proliferating the cells within the scaffold and forming blood vessels within the scaffold. This may be followed by transplanting the engineered tissue implant in vivo where nutrition and oxygen are provided to support the preloaded cells. | 01-31-2013 |
20130035767 | NEURAL GRAFT - A neural graft includes a biological substrate, a carbon nanotube structure and a neural network. The carbon nanotube structure is located on the biological substrate. The carbon nanotube structure includes a number of carbon nanotube wires crossed with each other to define a number of pores. The neural network includes a number of neural cell bodies and a number of neurites branched from the neural cell bodies. An effective diameter of each pore is larger than or equal to a diameter of the neural cell body, the neurites substantially extend along the carbon nanotube wires such that the neurites are patterned. | 02-07-2013 |
20130035768 | VARIABLE DENSITY TISSUE GRAFT COMPOSITION - Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient. | 02-07-2013 |
20130066438 | SYNTHETIC SCAFFOLDS AND ORGAN AND TISSUE TRANSPLANTATION - Articles, compositions, and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. Synthetic scaffolds for growing artificial tissue and organ transplants are also provided. | 03-14-2013 |
20130073054 | TISSUE SUPPORT STRUCTURE - An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second shape including a helix having a first ring and a second ring configured to exert a compressive force on a membrane interleaved between the first ring and the second ring and lying in a plane substantially perpendicular to an axis of the helix, the shape selectable based on an external stimulus. | 03-21-2013 |
20130079891 | TISSUE MODIFICATION - A tissue modification apparatus includes a first and a second guide, a first and a second set of mounts, and a first and a second actuator. The first guide defines a first axis, and the second guide defines a second axis intersecting the first axis. The mounts of the first set of mounts are movable relative to one another along the first axis, and the mounts of the second set of mounts are movable relative to one another along the second axis. The first actuator and the second actuator are each settable to a stress load, with the first actuator and the second actuator movable, respectively, along the first axis and the second axis to transmit each respective stress load to a piece of tissue mechanically coupled to the first and second set of mounts. | 03-28-2013 |
20130085579 | METHOD AND APPARATUS FOR A PROCESS CREATING AN INTERNAL TISSUE GRAFT FOR ANIMAL AND HUMAN RECONSTRUCTIVE PURPOSES - A method and apparatus is provided for creating an internal reconstruction tissue graft. Templates may be used to create a multitude of patterns in a variety of tissue reconstruction grafts. An apparatus may be used to create an internal tissue graft for reconstruction through either compression and/or removal of segments. An apparatus may be used, through either compression and or removal of segments of a preformed template made of synthetics and or metal that minors a template that can be used as an internal tissue graft for reconstruction. In a method, such as using software analysis and an apparatus, the physical properties of the tissue graft and its pre- and post-operative properties and appearance may be measured. | 04-04-2013 |
20130110254 | Woven Implantable Device | 05-02-2013 |
20130116799 | REINFORCED TISSUE GRAFT - A biocompatible tissue graft includes a first layer of a bioremodelable collageneous material, a second layer of biocompatible synthetic or natural remodelable or substantially remodelable material attached to the first layer; and at least one fiber that is stitched in a reinforcing pattern in the first layer and/or second layer to mitigate tearing and/or improve fixation retention of the graft, and substantially maintain the improved properties while one or more of the layers is remodeling. | 05-09-2013 |
20130123937 | METHOD OF PREPARATION OF BIOABSORBABLE POROUS REINFORCED TISSUE IMPLANTS AND IMPLANTS THEREOF - A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated. | 05-16-2013 |
20130123938 | STITCHABLE TISSUE TRANSPLANT CONSTRUCT FOR THE RECONSTRUCTION OF A HUMAN OR ANIMAL ORGAN - The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ. The tissue transplant construct ( | 05-16-2013 |
20130123939 | COMPOSITIONS AND METHODS FOR REPAIR OR REGENERATION OF SOFT TISSUE - Disclosed are bioscaffolds and methods for use in soft tissue repair. | 05-16-2013 |
20130131829 | CELL INDUCTION MATERIAL - The object of the present invention is to provide a cell induction material, which can be easily formed, has excellent moldability because sintering is unnecessary, and decreases a strain on a human body caused by the exposure of the ends of a titanium wire. A metal mesh made by stockinette stitching with titanium wire is formed into a predetermined shape, and a cell induction material obtained by pressing the formed metal mesh is used. Further, the cell induction material with substantially no ends of the titanium wire that can be sensed through the sense in the vicinity of the surface is used. | 05-23-2013 |
20130131830 | Textile-Templated Electrospun Anisotropic Scaffolds for Tissue Engineering and Regenerative Medicine - The present invention includes an anisotropic scaffold, which is prepared by electrospinning a solution of matrix material upon a textile template. The present invention further includes a method of preparing such scaffold. The anisotropic scaffold of the invention finds use in tissue engineering and regenerative medicine. | 05-23-2013 |
20130144400 | SCAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALS - A mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels within the scaffold to allow fluid flow into and within the scaffold. | 06-06-2013 |
20130144401 | APPARATUS INCLUDING MULTIPLE INVAGINATORS FOR RESTORING A GASTROESOPHAGEAL FLAP VALVE AND METHOD - A transoral gastroesophageal flap valve restoration assembly comprises a pair of tissue grippers. The device comprises an elongated member having a distal end arranged for being fed down an esophagus in communication with a stomach and a tissue shaper carried on the distal end of the longitudinal member. The tissue shaper comprises a first member adjacent the distal end of the elongated member and a second member. The first and second members are hingedly coupled to receive the stomach tissue to be shaped there between. The distal end of the elongated member has one of the tissue grippers that grips esophageal tissue oral of a Z line and the first member of the tissue shaper has the other tissue gripper that grips stomach tissue aboral of the Z line. A tissue fastener maintains the shaped stomach tissue. | 06-06-2013 |
20130158676 | FLOWABLE TISSUE PRODUCTS - The present disclosure provides tissue fillers. The tissue fillers can include a plurality of tissue particles formed from acellular tissue matrix fragments. The tissue fillers can be used to fill tissue sites, such as voids formed after tissue resection. | 06-20-2013 |
20130158677 | IMPLANTABLE REPAIR DEVICE - An implantable prosthesis for repairing or reinforcing a tissue or muscle wall defect including a first composite structure including at least one layer of a non-absorbable material, wherein the first composite structure has a central portion sized and shaped to cover at least a portion of the tissue or muscle wall defect, and has an outer periphery. The prosthesis further includes a second structure having a reinforced central region and an outer peripheral edge, a reinforcing element positioned between the first and second structures, and having an outer periphery and a stiffness greater than that of the first and second structures, and at least one pulling element coupled to the reinforced central region of the second structure. The second structure is coupled to the first structure substantially only at their respective peripheries. | 06-20-2013 |
20130173018 | METHOD FOR MANUFACTURING MULTILAYERED CELL SHEET, MULTILAYERED CELL SHEET HAVING VASCULAR NETWORK OBTAINED THEREBY, AND METHOD OF USE THEREOF - A method for manufacturing a multilayered cell sheet characterized in fabricating a vascular bed that constructs a vascular network extending to the surface from a channel for perfusing a medium, the channel being embedded in a gel; and layering a cell sheet onto the vascular bed to construct a vascular network in the cell sheet. This manufacturing method makes it possible to construct a vascular network in the cell sheet and to fabricate a thick multilayered cell sheet in a simple manner by layering cell sheets. Such a thick multilayered cell sheet is useful as an in-vivo tissue substitute in regenerative medicine involving a variety of tissues. | 07-04-2013 |
20130178949 | AIR IMPEDANCE ELECTROSPINNING FOR CONTROLLED POROSITY - Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering. | 07-11-2013 |
20130190893 | ELONGATED TISSUE MATRICES - Elongated and high aspect ratio tissue treatment products are provided. Methods of making and using the tissue treatment products are also provided. The tissue treatment products can be used as implants that conform to the site of implantation and resist migration away from their implantation site in viva | 07-25-2013 |
20130197662 | COLLAGEN GEL FOR BONDING POROUS COLLAGEN-BASED MATERIALS WITH NON-POROUS COLLAGEN-BASED MATERIALS - The invention discloses a process for fabricating a biomaterial, comprising: a) joining a porous collagen based-material with a non-porous collagen based-material by applying a controlled amount of a bonding layer of a gel comprising collagen to a bonding surface of the non-porous collagen based-material, and contacting a surface of the porous collagen based-material with the gel applied to the bonding surface to partially hydrate a section of the porous material at the interface between the materials; b) drying the gel to dry to bond the materials together; and c) cross-linking the collagens in the bonding layer. Also disclosed are biomaterials and implants produced using the fabrication process. | 08-01-2013 |
20130197663 | BIOMEDICAL PATCHES WITH ALIGNED FIBERS - A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes. | 08-01-2013 |
20130197664 | Electrospun Porous Media - Espun material may function as a filtration medium or be put to other uses. The espun material may comprise espun poly(tetrafluoroethylene) (espun PTFE). One or more layers of the espun material may be included. The properties of the espun material can be tailored. For example, a gradient fabric may include espun PTFE. The gradient fabric may include two or more layers of espun PTFE. | 08-01-2013 |
20130197665 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane. | 08-01-2013 |
20130197666 | METHODS AND DEVICES FOR PREPARING AND IMPLANTING TISSUE SCAFFOLDS - Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold. | 08-01-2013 |
20130197667 | Acellular Vascular Products - A product comprising a natural acellular xenogenic vascular tissue matrix having at least an 80% reduction in DNA content as compared to an untreated control vascular tissue matrix and being antigenically inert by being substantially free of epitopes capable of reacting with pre-formed human antibodies and also without having the ability to substantially activate complement. The invention also includes methods of preparing such products and uses of the products especially in bypass surgery. | 08-01-2013 |
20130197668 | STRUCTURE MODELED ON A BIOLOGICAL TISSUE AND METHOD FOR PRODUCING SAID STRUCTURE - The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there. | 08-01-2013 |
20130204392 | METHOD FOR PROMOTING STEM CELL CHONDROGENESIS - There is provided a method for promoting stem cell chondrogenesis, comprising the step of culturing a population of stem cells on a plurality of imprints disposed on a substrate, the imprints being configured to selectively promote chondrogenesis of the stem cells. | 08-08-2013 |
20130204393 | MULTI-LAYER TISSUE SYSTEMS AND METHODS - Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch. | 08-08-2013 |
20130204394 | THIN FILM TISSUE REPAIR MATRIX - A tissue repair matrix has an intricate pattern of loops, struts and bridges and is made of a super elastic alloy. The repair matrix includes hooks which improve the ingrowth when implanted and amorphic circles which provide rounded surfaces to the outer edges which made the repair matrix a-traumatic when implanted. When the repair matrix is cooled the molecular phase becomes martensitic which allows the tissue repair matrix to be compressed for easier insertion into a patient. When the tissue repair matrix is heated, the molecular phase changes to austenitic which causes the tissue repair matrix to expand to a size suitable for medical procedure. | 08-08-2013 |
20130211542 | SYNTHESIS OF NANOTOPOGRAPHIC BIOMIMETIC MEMBRANES FOR TISSUE CULTURE, ENGINEERING AND PROSTHETICS APPLICATIONS - The present invention provide methods for preparing nanostructured membranes. The methods include: providing a substrate with a charged silanized surface; forming a multilayered membrane containing at least two polyelectrolytes; inducing polyelectrolyte phase separation; crosslinking the multilayered membrane; and covalently linking the multilayered membrane to the silanized surface. Methods for fabricating membrane replicas are also disclosed, as well as devices such as cell- and tissue-culture substrates that contain the membranes and membrane replicas. Resulting materials exhibit topographic features and compliance of the extracellular matrix in vivo. | 08-15-2013 |
20130211543 | TISSUE SCAFFOLD WITH CONTROLLED DRUG RELEASE - A three-dimensional hybrid scaffold capable of supporting cell activities such as growth and differentiation, and capable of controlled release of active pharmaceutical ingredients, characterized in that the scaffold comprises a first and a second biocompatible material, said first material shaped as a framework forming one or more open networks of voids, said second material comprising an ion exchange material, said ion exchange material being loaded with one or more active pharmaceutical ingredients. | 08-15-2013 |
20130218293 | MEDICAL INSTRUMENT - A medical instrument includes a handpiece, a tank portion configured to house a fluid, a suction/discharge unit configured to change a volume or pressure of an inside of the tank portion to suction the fluid into the tank portion or discharge the fluid from the tank portion, and an operating unit providing a member different from the suction/discharge unit and configured to operate the suction/discharge unit. | 08-22-2013 |
20130218294 | Plasticized Bone and Soft Tissue Grafts and Methods of Making and Using Same - The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room. | 08-22-2013 |
20130226312 | METHOD FOR REDUCING REJECTION OF ALLOGENEIC CELL TRANSPLANT - The preset invention relates to a novel cell graft suitable for transplantation or cell therapy and the use thereof for treating diseases. In particular, the graft provided herein overcomes concomitant rejection when transplanted onto a patient, which is especially beneficial for the condition where allogeneic cells are used. Also provided is a process for preparing such grafts by culturing at least one cell type under hypoxic or anoxic conditions. | 08-29-2013 |
20130226313 | Bioactive Scaffold for Therapeutic and Adhesion Prevention Applications - A device for inhibiting adhesion of apposing human body tissue layers includes a scaffold having a designated mean pore size, relative density, and degradation half-life. The scaffold may be operably positioned between apposing tissue layers, such as proximate adhesiogenic layers at a wound site, so as to permit remesothelialization of the tissue without formation of fibrous adhesions. The scaffold device of the invention inhibits adhesion formation by promoting contractile cell migration away from the wound site for a predetermined period of time. The invention further relates to device and methods for promoting internal tissue regeneration, and for provision and/or dispensation of therapeutic and/or diagnostic agents in vivo. | 08-29-2013 |
20130238100 | AMNION AND CHORION CONSTRUCTS AND USES THEREOF IN ABDOMINAL SURGERY - A construct for use in an abdominal surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and has a size and shape appropriate for covering an incision or a surgical site resulting from the surgery. Methods of preparing the construct and using it in an abdominal surgery are also described. The products and methods improve the performance of the abdominal surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection. | 09-12-2013 |
20130245784 | METHOD FOR FORMING A TISSUE CONSTRUCT AND USE THEREOF - The present invention relates to a method for forming a tissue construct having a composite structure. The method includes providing a biodegradable substrate, wherein the substrate is adapted to allow deposition or growth of a plurality of cells; providing a vascularized layer comprising a plurality of blood vessels therein; and adhering the vascularized layer to the substrate. | 09-19-2013 |
20130274893 | METHOD FOR ENHANCING ULTRASOUND VISIBILITY OF HYPERECHOIC MATERIALS - A hydrogel plug is placed under stress during its curing stage, in one embodiment, by application of an externally applied force. The stress may also be induced during or after the dehydration process. The direction of the externally applied force increases the length, width, depth, or radial extent of the plug. The elastic limit of the plug is exceeded when the external force is applied so that the plug substantially retains its stressed size and shape when the externally applied force is removed. When the stretched or otherwise deformed dehydrated plug is hydrated, it substantially returns to the configuration it had prior to its dehydration and prior to the application of the externally applied force. | 10-17-2013 |
20130282140 | BI-PHASIC COMPRESSED POROUS REINFORCEMENT MATERIALS SUITABLE FOR IMPLANT - A high strength porous biphasic polymeric reinforcement material manufactured by a compression and/or sintering process is disclosed. The material results in a network of interconnected collapsed pores, which forces thin overlapping walls and passages to be created. The network provides permeable access for fluid migration throughout the material. The strength and/or permeability are advantageous for medical devices and implants. | 10-24-2013 |
20130297040 | IMPLANT HAVING A CORE AND A TUBE ENCASING THE CORE - The present invention relates to an implant comprising: —a core material comprising polydimethylsiloxane or at least one hydrogel polymer; —a tube encasing said core material comprising an ethylene vinyl acetate polymer or at least one hydrogel polymer; —a sealant for closure of the open ends of said tube comprising polydimethylsiloxane or a mono-, di-, or triacetoxy derivative thereof, or at least one hydrogel polymer; and —at least one active ingredient; wherein said at least one active ingredient is selected from the group comprising celecoxib, sulindac, tamoxifen, oestrogen, oestradiol, ethinyl oestradiol, mestranol, dienogest, norgestrel, levonorgestrel, desogestrel, norgestimate, ethynodiol diacetate, leuprorelin, buserelin, gonrelin, triptorelin, nafarelin, deslorelin, histrelin, and supprelin; and with the proviso that when the sealant is said at least one hydrogelpolymer, the core material comprises polydimethylsiloxane. Furthermore, the invention relates to an implant for use as a medicament. In particular, the invention relates to an implant for use in the treatment of endometriosis. | 11-07-2013 |
20130304233 | CONTINUOUS DIGITAL LIGHT PROCESSING ADDITIVE MANUFACTURING OF IMPLANTS - A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer. | 11-14-2013 |
20130317623 | LIGHTWEIGHT QUADRIAXIAL SURGICAL MESH - A method for making a lightweight surgical mesh, having the steps of applying a first set of filaments in a first wale direction and forming a first series of loops at each of a plurality of courses. Applying a second set of filaments in the first wale direction and forming a second series of loops at a first adjacent wale to the first wale direction and a third series of loops at a second adjacent wale opposite the first adjacent wale along the plurality of courses. Further, applying a third set of filaments in the first wale direction so that the second series of loops are formed at the second adjacent wale and the third series of loops are formed at first adjacent wale along the plurality of courses. Additionally, applying a fourth set of filaments that interlace repeatedly with the first set of filaments along the first wale direction. | 11-28-2013 |
20130317624 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane. | 11-28-2013 |
20130338791 | LAYERED FIRBROUS CONSTRUCT - The present invention relates to a layered fibrous construct for use as a scaffold for repairing or replacing cartilage or cartilage-like tissue, and a process for the production thereof. | 12-19-2013 |
20140005797 | THREE-DIMENSIONAL POROUS SCAFFOLD AND MANUFACTURING METHOD THEREOF | 01-02-2014 |
20140012395 | METHOD OF MENDING A GROINAL DEFECT - A method of mending a groinal defect such as an indirect inguinal hernia, a direct inguinal hernia, and/or a femoral hernia. A space between the external oblique aponeurosis and the internal oblique aponeurosis is dissected superiorly and laterally to create a site for receiving a lateral portion of a prosthetic repair patch. Dissection medially and inferiorly between the two aponeuroses leads to a transversalis fascia, which is explored downwardly and, at the pubic bone, dissected to reach the preperitoneal space of Retzius. A medial portion of a prosthetic repair patch may be positioned in the space of Retzius with a lateral portion of the prosthetic repair patch positioned in the dissected space between the two aponeuroses. So positioned, the prosthetic repair patch protects the myopectineal orifice that is susceptible to each of the indirect inguinal hernia, direct inguinal hernia, and femoral hernia. | 01-09-2014 |
20140018936 | INCREASING SURVIVAL OF FREE TISSUE GRAFTS AND FLAPS USING PHOSPHODIESTERASE TYPE 5 (PDE5) INHIBITORS - The present invention relates to methods of tissue grafting and microvascular free flap transfer that involve administering a phosphodiesterase type-5 inhibitor to the tissue graft or microvascular free flap to produce a treated graft or flap, and implanting the treated graft or flap into a recipient site of a host subject. | 01-16-2014 |
20140018937 | VARIABLE DENSITY TISSUE GRAFT COMPOSITION AND METHODS OF MAKING AND USING THE SAME - Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient. | 01-16-2014 |
20140052273 | FILLER FOR REMOVING WRINKLES - The present invention relates to a filler for removing wrinkles, which comprises: a thin and long tubular main body to be placed so as to penetrate through subcutaneous tissue; and through-holes for guiding tissue cells surrounding the main body into the main body, so as to form fibrous tissue, wherein the through-holes are formed so as to communicate with a hollow portion formed in said main body in the lengthwise direction from the outer surface of said main body. The filler for removing wrinkles according to the present invention is prevented from being deformed or moved by pressure on the skin or by an external force arising after being inserted into the subcutaneous tissue, and can be applied to various body parts having wrinkles, including deep wrinkles. Furthermore, the wrinkle-removing effects of the filler of the present invention may last (semi)permanently. | 02-20-2014 |
20140074253 | SCAFFOLDS COMPRISING NANOELECTRONIC COMPONENTS FOR CELLS, TISSUES, AND OTHER APPLICATIONS - The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like. | 03-13-2014 |
20140094930 | CENTRIFUGE - Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. | 04-03-2014 |
20140094931 | REINFORCED TISSUE GRAFT - A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch. | 04-03-2014 |
20140107803 | ENGINEERED TISSUE SCAFFOLDS AND SUPPORTS THEREFOR - According to some aspects, supports are provided for producing artificial tissue scaffolds. | 04-17-2014 |
20140107804 | SCAFFOLDS FOR ORGAN RECONSTRUCTION AND AUGMENTATION - Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels. | 04-17-2014 |
20140128991 | BIOERODIBLE NANO-FIBROUS AND NANO-POROUS CONDUCTIVE COMPOSITES - A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth. | 05-08-2014 |
20140135945 | POLYMER NANOFIBER SCAFFOLD FOR A HEPARIN / FIBRIN BASED GROWTH FACTOR DELIVERY SYSTEM - A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues. | 05-15-2014 |
20140148914 | SURGICAL GRAFTS, AND IMPLEMENTS FOR DELIVERING SAME - Described are graft devices useful for treating surgical defects, delivery implements for delivery of the graft devices, combinations thereof, and methods for the preparation and use thereof. In certain aspects a tonsillectomy graft can include convexly curved outer edges, where the graft is sized and configured such that these outer edges reside proximate and along tonsillar pillars bounding a surgical tonsillectomy defect. The graft can include one or more pull tethers laced to the graft and functional to draw these outer edges toward one another when tensioned. The graft can be combined with a delivery implement having a delivery head and attached handle, where the delivery head is sized for receipt onto the tonsillectomy defect to deliver the graft. Additional product features, as well as associated methods, are also described. | 05-29-2014 |
20140148915 | GENERATING CK19-POSITIVE CELLS WITH HAIR-LIKE STRUCTURES FROM WHARTONS JELLY - A method of differentiating cells into CK19-positive cells capable of producing hair follicle-like and hair structure-like can include: providing a tissue scaffold; seeding cells into the scaffold, the cells being capable of differentiation; incubating the scaffold having the cells in a cell growth media; and incubating the scaffold having the cells in an osteogenic differentiation medium sufficient for CK19-positive cells to be generated in the scaffold. The tissue scaffold can be a decellularized Whartons' jelly matrix. The cell growth media excludes osteogenic differentiation components: dexamethasone, β-glycerophosphate, 1α,25-hydroxyvitamin D3, and ascorbic acid 2-phosphate. The osteogenic differentiation medium includes the osteogenic differentiation components. The cells can be mesenchymal cells, such as WJMSCs. | 05-29-2014 |
20140163695 | ARTHROSCOPIC TISSUE SCAFFOLD DELIVERY DEVICE - A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube. | 06-12-2014 |
20140172119 | BIOCOMPATIBLE EXTREMELY FINE TANTALUM FIBER SCAFFOLDING FOR BONE AND SOFT TISSUE PROSTHESIS - A tissue implant member for implanting in living tissue is provided. The implant is formed of a fibrous structure of tantalum filament having a diameter less than 5 microns. | 06-19-2014 |
20140180436 | METHOD AND PROSTHESIS FOR PERCUTANEOUS HERNIA REPAIR - A method and prosthesis is provided for percutaneous repair of an anatomical defect, such as an inguinal hernia. The method involves percutaneously accessing the inguinal canal of a patient. Following hernia reduction, if required, the hernia defect may be accessed and repaired percutaneously from within the inguinal canal. An implantable prosthesis may be percutaneously delivered into the inguinal canal. The prosthesis may be advanced along the inguinal canal from the percutaneous entry location to the defect site, where it may be deployed over and/or within the defect. A biocompatible foam material may be percutaneously delivered into the inguinal canal to reduce and/or repair the hernia defect. The foam may fill and solidify in the canal to prevent abdominal viscera from reentering the canal. Ablative therapy may be performed within the inguinal canal to cause a fibrotic response resulting in scar tissue formation and/or tissue shrinkage that narrows the canal. | 06-26-2014 |
20140180437 | Plasticized Bone and Soft Tissue Grafts and Methods of Making and Using Same - The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room. | 06-26-2014 |
20140188250 | MODIFIABLE MEDICAL GRAFTS AND RELATED METHODS AND APPARATUSES - Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. Also described are methods for making and using these medical graft materials and devices. | 07-03-2014 |
20140207248 | HIERARCHICAL MULTISCALE FIBROUS SCAFFOLD VIA 3-D ELECTROSTATIC DEPOSITION PROTOTYPING AND CONVENTIONAL ELECTROSPINNING - A hierarchical multiscale fibrous scaffold comprises multiple patterned layers of microfibers with one or more layers of nanofibers interleaved therebetween. In a method for making such scaffolds, electrodeposition or near-field electrospinning is used to deposit patterned layers of microfibers in a stack. Conventional electrospinning is used to deposit nanofibers on the layers of microfibers. The method may be used to tune the mechanical properties of the scaffold, facilitated by microfibers, and the biological features of the scaffold, facilitated by nanofibers. Scaffolds produced by such a process may have highly biomimetic architectures, and allow rapid cellular infiltration and sustainable cell growth for multiple tissue types. | 07-24-2014 |
20140207249 | Tissue Repair Implant - Described herein are tissue repair implants comprising at least a first layer of peritoneal membrane. The first layer of peritoneal membrane can be located adjacent to a second layer of peritoneal membrane and can be in direct contact with the second layer of peritoneal membrane. Additional layers (e.g., a third or fourth layer) can be included. Where more than one layer is present, the layers can be affixed to one another. For example, a first layer of peritoneal membrane can be attached to the second layer of peritoneal membrane by an adhesive bond, suture, or staple. One or more of the peritoneal membranes can be non-crosslinked, partially crosslinked, or substantially fully crosslinked. Any of the layers of peritoneal membrane may be attached to a wall (e.g., an interior or exterior wall) of an abdominal tissue by an adhesive, suture, and/or staples. | 07-24-2014 |
20140207250 | Tissue Scaffold - A process of forming a tissue scaffold is described, the process comprising electrospinning polymer fibers from a spinneret onto a tissue scaffold template. In embodiments, the fibers are plasma-treated between the spinneret and the template. The scaffold may be constructed of alternating layers of aligned and randomly oriented fibers. The scaffold may be heat treated to control the mechanical properties of the scaffold, such as density, pore size and pore interconnectivity. | 07-24-2014 |
20140214176 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane. | 07-31-2014 |
20140222161 | THREE-DIMENSIONAL POLYMERIC MEDICAL IMPLANTS - The invention relates to a three-dimensional medical implant, comprising a first thin porous component, and a first load-bearing and volume-creating component, which is connected to the first thin porous component; wherein the load-bearing and volume-creating component comprises an organized structure. | 08-07-2014 |
20140222162 | CONNECTIVE TISSUE REPAIR TECHNOLOGY - An implantable prosthetic device for the repair of damaged cartilage including methods of implantation and repair. The prosthetic device is formed from a biocompatible pad having an open structure connected to a textile or non-woven sheet-like anchor. In one embodiment the anchor comprises legs that extend away from a perimeter region of the pad and spaced apart along their respective lengths such that an in unfolded orientation, the longitudinal edges of neighbouring legs are not in contact with one another and a spatial gap is provided between the anchoring legs. The anchor may also be provided in the form of strips to which anchorage sutures or other medical cords may be attached to fixate the device between connective tissue. | 08-07-2014 |
20140222163 | ARTIFICIAL DURA MATER AND MANUFACTURING METHOD THEREOF - Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents. | 08-07-2014 |
20140222164 | Reinforced Tissue Patch - A method of improving the mechanical properties of a tissue patch is provided. The method includes the steps of providing a tissue patch and placing at least one barbed suture along at least a portion of the tissue patch. The method may further include the step of placing one or more additional barbed sutures in a laterally spaced relation to the barbed suture. The barbed suture may be biodegradable or non-biodegradable. | 08-07-2014 |
20140236313 | MICROSTRUCTURED ADHESION SUBSTRATE FOR ANIMAL OR HUMAN CELLS - The present invention relates to an adhesion substrate for at least one animal or human cell on the surface of which is generated an adhesion pattern for at least one animal or human cell, said pattern including at least two areas adhering to said cell, which are spaced apart by an area not adhering to said cell on which a polymer not adhering to said cell is immobilized, characterized in that the polymer is selected so as to have a conformation which may be modified by varying a parameter of the environment in which the substrate is found, to a method for preparing such a substrate and to the cell analysis methods using such a substrate. | 08-21-2014 |
20140243995 | STACKED PLANAR SHEET TISSUE ENGINEERING SCAFFOLDS WITH 3D STRUCTURAL ORDER - A three-dimensional tissue engineering scaffold device and related methods are disclosed herein. The tissue engineering scaffold includes a plurality of polymers sheets. Each polymer sheet includes a plurality of micro-scale pores defined through the polymer sheet. The polymer sheets of the tissue engineering scaffold are aligned and stacked such that some of the pores of neighboring sheets are offset along at least one axis of the pores. The offset pores create features within the tissue engineering scaffold. In some implementations, the tissue engineering scaffold device is seeded with cells. In certain implementations, the tissue engineering scaffold is either implanted into a patient or used to grow functional tissue ex vivo. | 08-28-2014 |
20140257516 | Connective-Tissue-Based or Dermal-Tissue-Based Grafts/Implants - The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell. | 09-11-2014 |
20140277575 | Randomly Uniform Three Dimensional Tissue Scaffold of Absorbable and Non-Absorbable Materials - An implantable structure, method for making the structure and method for using the structure, where the structure includes a combination of non-absorbable and absorbable components, and the implantable structure has a randomly uniform array of materials. The resulting implantable structure provides improved tissue ingrowth and flexibility after implantation and after absorption of the absorbable materials. | 09-18-2014 |
20140277576 | Randomly Uniform Three Dimensional Tissue Scaffold of Absorbable and Non-Absorbable Materials - An implantable structure, method for making the structure and method for using the structure, where the structure includes a combination of non-absorbable and absorbable components, and the implantable structure has a randomly uniform array of materials. The resulting implantable structure provides improved tissue ingrowth and flexibility after implantation and after absorption of the absorbable materials. | 09-18-2014 |
20140277577 | PEPSINIZED COLLAGEN IMPLANTS AND BIOMEDICAL USES THEREOF - Disclosed are pepsinized collagen implants, such as membranes and sponges, and methods of making them, which entails solubilizing pepsinized collagen in a buffer containing a polyol, e.g., mannitol or sorbitol, wherein the buffer has a substantially neutral pH. Methods of using the pepsinized collagen implants for clinical applications are also disclosed. | 09-18-2014 |
20140277578 | Biodegradable Composite Scaffold for Repairing Defects in Load-Bearing Bones - A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising a core of biocompatible, biodegradable inorganic glass fibers; and a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core. | 09-18-2014 |
20140277579 | USES OF AMNION CONSTRUCTS IN MINIMALLY INVASIVE SURGERIES - A construct for use in a minimally invasive surgery is described. The construct contains an allograft having at least one layer of human amnion and chorion tissues, and is adapted for insertion into a small incision or a cannula employed in the minimally invasive surgery for access to the surgical site. The allograft has a shape appropriate for covering the surgical site. Methods of preparing the construct and using it in a minimally invasive surgery are also described. The products and methods improve the performance of the minimally invasive surgery, e.g., by reducing adhesions, scar formation while also reducing inflammation and risk of post-operative infection. | 09-18-2014 |
20140330391 | PLACENTAL TISSUE GRAFTS - A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion. | 11-06-2014 |
20140336780 | Extracellular Matrix (ECM) Structures for Tissue Regeneration - An extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having a a sheet member comprising small intestine submucosa (SIS), the SIS sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ECM structure having a cavity therein is formed, the ECM structure further including an ECM composition that is disposed in the ECM structure cavity, the ECM composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor. | 11-13-2014 |
20140343688 | LAMINATED TISSUE GRAFTS COMPOSED OF WHARTON'S JELLY AND METHODS OF MAKING AND USING THE SAME - Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes. | 11-20-2014 |
20140343689 | SYSTEM AND METHOD FOR PERCUTANEOUSLY ADMINISTERING REDUCED PRESSURE TREATMENT USING A FLOWABLE MANIFOLD - A reduced pressure delivery system for applying a reduced pressure to a tissue site includes a manifold delivery tube having a passageway and a distal end, the distal end configured to be percutaneously inserted and placed adjacent the tissue site. A flowable material is provided and is percutaneously deliverable through the manifold delivery tube to the tissue site. The flowable material is capable of filling a void adjacent the tissue site to create a manifold having a plurality of flow channels in fluid communication with the tissue site. A reduced pressure delivery tube is provided that is capable of fluid communication with the flow channels of the manifold. | 11-20-2014 |
20140343690 | TISSUE SCAFFOLD - A tissue scaffold includes a first film having a plurality of cell openings and a second film adjacent the first film and having a plurality of cell openings larger than the cell openings of the first film. The cell openings of the first film interconnect with the cell openings of the second film to define pathways extending through the first and second films. | 11-20-2014 |
20140379094 | FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 12-25-2014 |
20140379095 | TISSUE MODIFICATION - A tissue modification apparatus includes a first and a second guide, a first and a second set of mounts, and a first and a second actuator. The first guide defines a first axis, and the second guide defines a second axis intersecting the first axis. The mounts of the first set of mounts are movable relative to one another along the first axis, and the mounts of the second set of mounts are movable relative to one another along the second axis. The first actuator and the second actuator are each settable to a stress load, with the first actuator and the second actuator movable, respectively, along the first axis and the second axis to transmit each respective stress load to a piece of tissue mechanically coupled to the first and second set of mounts. | 12-25-2014 |
20150032223 | CELL SHEET TRANSPLANTATION DEVICE AND METHOD FOR USING THE SAME - A cell sheet transplantation device having a plane for transplanting a sheet of cultured cells, the device comprising, in the plane in the same direction, (1) a planar surface portion for capturing a cell sheet while maintaining a sheet-shaped form, and (2) suction holes for immobilizing a transplantation site by suction, the suction holes being positioned around the planar surface portion. By using the cell sheet transplantation device, a cultured cell sheet can be detached effectively, and the detached cultured cell sheet can be transplanted in an effective and simple manner. | 01-29-2015 |
20150032224 | IMPLANT - The present invention relates to an implant comprising at least two layers made of fibers and bioactive material arranged between said at least two layers, the bioactive material being selected from the group consisting of bioactive glass, hydroxyapatite, tricalciumphosphate and mixtures thereof. In the implant, at least one of the layers is at least mainly formed of a mesh, which is made of glass fibers having a diameter of 3-100 μm, and wherein the mesh size is selected such that the bioactive material is retained within the implant. In addition, the layers are embedded in a matrix made of a resin selected from the group consisting of polyesters, epoxies, acrylates and mixtures thereof, and the layers are attached to each other along the contour of the implant. | 01-29-2015 |
20150045909 | HIGHLY POROUS POLYVINYL HYDROGELS FOR CARTILAGE RESURFACING - A method of making a creep resistant, highly lubricious, tough hydrogel includes the steps of preparing a first solution including polyacrylamide-co-acrylic acid and another polymer, such as polyvinyl alcohol), and introducing a second solution a gellant into the first solution to form the hydrogel. The first solution can be heated to a first temperature above room temperature, and the combination of the first solution and the second solution can be cooled to a second temperature at or below room temperature. The hydrogel can be used for cartilage repair or in an interpositional device that requires mechanical integrity, high water content, and excellent lubricity in order to fully function under the high stress environment in the joint space and withstand high loads of human joints. | 02-12-2015 |
20150073565 | DEVICES, SYSTEMS, AND METHODS TO FIXATE TISSUE WITHIN THE REGIONS OF BODY, SUCH AS THE PHARYNGEAL CONDUIT - Devices, systems and methods develop static and/or kinetic and/or pressure forces to fixate or brace tissue in targeted pharyngeal structures and individual anatomic components within the pharyngeal conduit. | 03-12-2015 |
20150100134 | Extracellular Matrix Encasement Structures and Methods - A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue. | 04-09-2015 |
20150105863 | FIBER-REINFORCED HYDROGEL COMPOSITES AND METHODS OF FORMING FIBER-REINFORCED HYDROGEL COMPOSITES - A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 μm. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, (ii) thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method (iii) using the fiber-reinforced composite are also provided. | 04-16-2015 |
20150105864 | Biocompatible Implants and Methods of Making and Attaching the Same - The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided. | 04-16-2015 |
20150119994 | INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS - A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described. | 04-30-2015 |
20150127116 | DEHYDRATION DEVICE AND METHODS FOR DRYING BIOLOGICAL MATERIALS - This invention relates generally to a dehydration device and methods for drying biological materials to produce dried biological materials having enhanced structural properties. More specifically, the invention relates to a dehydration device and related methods for drying biological tissue to produce enhanced tissue grafts. | 05-07-2015 |
20150134076 | HYBRID ADJUNCT MATERIALS FOR USE IN SURGICAL STAPLING - Implantable materials for use with end effectors like surgical stapling devices, and methods associated with the operation of such end effectors, are provided. In one exemplary embodiment, a staple cartridge assembly includes a cartridge body and a hybrid adjunct material associated therewith. The hybrid adjunct material can include one or more biologic materials, such as a biologic tissue membrane, and one or more synthetic materials, such as a synthetic absorbable polymer. The synthetic absorbable polymer can be associated with the membrane such that the polymer provides structural integrity to the membrane so that the membrane can be securely coupled to the cartridge body. Both the membrane and the polymer can be configured to be securely attached to the tissue by staples of the cartridge body. Other implants, devices, and methods for surgical stapling are also provided. | 05-14-2015 |
20150134077 | SEALING MATERIALS FOR USE IN SURGICAL STAPLING - Implantable materials for use with end effectors like surgical stapling devices, and methods associated with the operation of such end effectors, are provided herein. In one exemplary embodiment, a tissue reinforcement material is releasably retained on a portion of a surgical stapler end effector for delivery to tissue upon deployment of staples. The tissue reinforcement material comprises a plurality of fibers having an arrangement configured to compress and seal around a fastener component inserted therethrough. Other implants, devices, and methods for surgical stapling are also provided. | 05-14-2015 |
20150142128 | TISSUE REGENERATION CONSTRUCT AND METHOD FOR PRODUCING TISSUE REGENERATION CONSTRUCT - Provided is a tissue regeneration construct having a good engraftment property and capable of promoting a stable and favorable regeneration to a target site, the tissue regeneration construct being a member to be applied to a target site for transplantation and regeneration to regenerate tissue, including a transplant body, and an engraftment layer arranged overlapping at least a part of an outer surface of the transplant body, wherein: the transplant body includes a support, cells for regenerating the tissue that are arranged at least either one of a space between the supports and a space formed by a pore inside the support, and a base material for retaining the cells; the base material of the engraftment layer is gelatinous; and the engraftment layer is a layer in which the support does not exist. | 05-21-2015 |
20150289945 | COMPUTER AIDED IMPLANTATION OF BODY IMPLANTS - Systems and methods are disclosed for cosmetic injection. The apparatus includes a processor; a 3D imaging system coupled to the processor; and an injector controlled by the processor to inject filler into a patient. | 10-15-2015 |
20150313704 | CARDIAC TISSUE CONSTRUCTS AND METHODS OF FABRICATION THEREOF - Methods and devices are provided for the formation of cardiac tissue constructs. In some embodiments, methods are provided for forming cardiac tissue constructs that including cardiomyocytes, non-myocytes, and extracellular matrix, and which exhibit properties associated with healthy cardiac tissue. In some embodiments, microfabrication platforms are provided to support the transmission of dynamic electromechanical forces, such that the cardiac microtissue constructs may be formed mimicking the basic microenvironment found in the heart. The microfabrication platform may include retaining features for stabilizing the position of the microtissue construct during its formation, and the microfabrication platform may include a ramped support configured to produce tissue constructs having a ring geometry. In some embodiments, the microfabrication platform may be configured to for the application of point electrical stimulation, and/or to amplify the transduction of force into a visible displacement. | 11-05-2015 |
20150328363 | USE OF SELF-ASSEMBLING POLYPEPTIDES AS TISSUE ADHESIVES - The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair. | 11-19-2015 |
20150342719 | ELECTROSTATIC-ASSISTED FIBER SPINNING METHOD AND PRODUCTION OF HIGHLY ALIGNED AND PACKED HOLLOW FIBER ASSEMBLY AND MEMBRANE - The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/−10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications. | 12-03-2015 |
20150351931 | Methods and Devices for Delivering and Affixing Tissue Scaffolds - Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism. | 12-10-2015 |
20150352255 | PREPARATION OF EXTRACELLULAR MATRIX-MODIFIED TISSUE ENGINEERED NERVE GRAFTS FOR PERIPHERAL NERVE INJURY REPAIR - A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft. | 12-10-2015 |
20150359621 | SYNTHETIC SCAFFOLDS - Aspects of the invention relate to a combination of techniques and/or materials that can be used to form a synthetic scaffold for solid and/or hollow organs or tissue. In some embodiments, methods are provided that involve assembling a synthetic scaffold using a first material for a first structural component and a second material for a second structural component, in which the first or second structural component is a perfusion pathway. In some embodiments, materials (e.g., synthetic materials) for the scaffold are printed, molded, cast, polymerized, or electrospun. In some embodiments, a scaffold may mimic a natural scaffold or several features of a natural scaffold. | 12-17-2015 |
20150359622 | Extracellular Matrix Constructs for Treating Damaged Biological Tissue - Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue. | 12-17-2015 |
20150359623 | METHOD FOR USE OF A DOUBLE-STRUCTURED TISSUE IMPLANT FOR TREATMENT OF TISSUE DEFECTS - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects. | 12-17-2015 |
20160000546 | DEVICES, METHODS, AND SYSTEMS RELATED TO EXPANDABLE IMPLANTS - Certain embodiments described herein relate to expandable, reversible implants. In an embodiment, the implants are controllable by way of at least one biochemical, chemical, or physical means. In an embodiment, the implants are programmable and/or pre-programmed for a particular level of expansion and/or contraction. In an embodiment, the implants are controlled remotely from a control source that is external to the subject's body. | 01-07-2016 |
20160000547 | DEVICES, METHODS, AND SYSTEMS RELATED TO EXPANDABLE IMPLANTS - Certain embodiments described herein relate to expandable, reversible implants. In an embodiment, the implants are controllable by way of at least one biochemical, chemical, or physical means. In an embodiment, the implants are programmable and/or pre-programmed for a particular level of expansion and/or contraction. In an embodiment, the implants are controlled remotely from a control source that is external to the subject's body. | 01-07-2016 |
20160000548 | DEVICES, METHODS, AND SYSTEMS RELATED TO EXPANDABLE IMPLANTS - Certain embodiments described herein relate to expandable, reversible implants. In an embodiment, the implants are controllable by way of at least one biochemical, chemical, or physical means. In an embodiment, the implants are programmable and/or pre-programmed for a particular level of expansion and/or contraction. In an embodiment, the implants are controlled remotely from a control source that is external to the subject's body. | 01-07-2016 |
20160000968 | PLACENTAL TISSUE GRAFTS AND IMPROVED METHODS OF PREPARING AND USING THE SAME - Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion which has been decellularized and at least one layer of chorion. Also described herein are methods for making and using the tissue grafts. | 01-07-2016 |
20160053134 | PEM LAYER-BY-LAYER SYSTEMS FOR COATING SUBSTRATES TO IMPROVE BIOACTIVITY AND BIOMOLECULE DELIVERY - The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates' surface. The invention is particularly suitable for coating substrates employed for medical applications, such as but not limited to medical implant devices for drug and/or biologics delivery in a patient. The substrate has a positive or negative charge. The polyelectrolyte multilayer coatings include at least a first polymer layer and a second polymer layer. The first polymer and second polymer have opposite charges. Each of the polymer layers is individually applied using a layer-by-layer such that an alternating charge multilayer coating is formed. | 02-25-2016 |
20160058534 | BIOCOMPATIBLE TISSUE GRAFT - Biocompatible tissue grafts are provided. The biocompatible tissue grafts comprise a bulk graft comprising a biocompatible material and having at least a first surface. The biocompatible tissue grafts also comprise a coating comprising a hydrogel and being immobilized on the bulk graft at the first surface. The biocompatible material comprises at least one of a biologic material or a biologic-synthetic composite material. The hydrogel comprises cross-linked hydroxyphenyl-substituted hyaluronan (HPS-HA), cross-linked hydroxyphenyl-substituted collagen (HPS-C), or both. The cross-linked HPS-HA, cross-linked HPS-C, or both have been formed by cross-linking of hydroxyphenyl groups of HPS-HA, HPS-C, or both to form dihydroxyphenyl bridges. Also disclosed are methods for repair of tissue damage in a subject in need thereof. The methods comprise surgically implanting the biocompatible tissue graft into a site of the tissue damage in the subject. | 03-03-2016 |
20160058542 | Chondroitin Sulfate Proteoglycan Containing Implants for Guided Nerve Regeneration and Methods of Manufacture Thereof - The invention relates to biocompatible implants with enhanced guided nerve axon regeneration and methods of manufacture thereof. | 03-03-2016 |
20160135940 | Elongated Tissue Matrices - Elongated and high aspect ratio tissue treatment products are provided. Methods of making and using the tissue treatment products are also provided. The tissue treatment products can be used as implants that conform to the site of implantation and resist migration away from their implantation site in vivo. | 05-19-2016 |
20160143738 | Biological Constructs for Treating Damaged Organs and Tissue - Biological constructs that can be engineered into a variety of shapes and employed to treat, augment and/or support damaged or diseased mammalian organs and/or tissue related thereto. The shapes include jackets and bands that are configured to encase a preselected region of a mammalian organ. | 05-26-2016 |
20160157982 | Vascular casted prostheses and methods of forming same for treating biological tissue - Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition. | 06-09-2016 |
20160157983 | Vascular casted prostheses and methods of forming same for treating biological tissue - Methods of treating biological tissue with bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition. | 06-09-2016 |
20160157984 | Vascular casted prostheses and methods of forming same for treating biological tissue - Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition. | 06-09-2016 |
20160184069 | HIGH-STRENGTH BIOLOGICAL SCAFFOLD MATERIAL AND PREPARATION METHOD THEREOF - A high-strength biological scaffold and preparation method thereof. The biological scaffold is comprised of a framework of boiled-off silk woven material, the form of the framework is determined by actual needs; the framework surface is coated with a layer of silk protein scaffold material, fibroin protein/gelatin biological scaffold material or fibroin protein/collagen biological scaffold material having a thickness of 100 micrometers to 5 centimeters. The high-strength biological scaffold material has high tear resistance strength and mechanical strength and good biocompatibility, has a porous structure suitable for tissue regeneration, and can be used for preparing anal fistula repair plugs. | 06-30-2016 |
20160200043 | 3-DIMENSIONAL BIOSCAFFOLDS | 07-14-2016 |
20170232154 | Materials For Soft And Hard Tissue Repair | 08-17-2017 |
20180021140 | HIGH SPEED 3D PRINTING SYSTEM FOR WOUND AND TISSUE REPLACEMENT | 01-25-2018 |