Class / Patent application number | Description | Number of patent applications / Date published |
548490000 | The five-membered hetero ring contains one double bond only (i.e., indolines) | 15 |
20090088577 | PRODUCTION OF MONATIN ENANTIOMERS - Methods for the preparation of the high intensity sweetener, monatin, 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)indole, its salts and internal condensation products thereof, including methods applicable to the large-scale production of monatin are described. | 04-02-2009 |
20090088578 | NUCLEAR MAGNETIC RESONANCE IMAGING OF SELECTIVE SMALL MOLECULE DRUGS AS CONTRAST AGENTS - Imaging agents for magnetic resonance imaging are disclosed. Also disclosed are methods of non-invasively generating a visible image of a target tissue. In some embodiments, the discloses methods include the steps of (a) providing a contrast enhancement agent comprising a small molecule that binds to a biomolecule present in the target tissue; (b) introducing the contrast enhancement agent into the target tissue; and (c) scanning the target tissue using magnetic resonance imaging, whereby a visible image of the target tissue is non-invasively generated. Further discloses are methods for monitoring a response to a therapy, methods for selecting a therapy for a subject, methods for delineating a boundary between a diseased cell and a non-diseased cell in a tissue, and methods for assessing the degree to which a target tissue has been removed from a subject. | 04-02-2009 |
20100105924 | PROCESSES OF PRODUCING GLUTAMIC ACID COMPOUNDS AND PRODUCTION INTERMEDIATES THEREFORE AND NOVEL INTERMEDIATE FOR THE PROCESSES - The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. | 04-29-2010 |
20110065929 | HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST - Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity. | 03-17-2011 |
20120197027 | Quinazoline Derivatives as Angiogenesis Inhibitors - The invention relates to the use of compounds of formula (I) and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. | 08-02-2012 |
20160168043 | METHOD FOR THE METHYLATION OF NITROGEN-CONTAINING ORGANIC COMPOUNDS | 06-16-2016 |
548491000 | Chalcogen or nitrogen attached indirectly to the five-membered hetero ring by acyclic nonionic bonding | 9 |
20080207919 | Novel Polymorphic Forms Of Fluvastatin Sodium And Process For Preparing The Same - Disclosed herein are novel polymorphic forms of Fluvastatin sodium, wherein said polymorphic forms are designated as J | 08-28-2008 |
20080207920 | PROCESS FOR PRODUCING AN OPTICALLY ACTIVE COMPOUND - The present invention provides a process for selectively producing an enantiomer at position 4 of an optically active compound in the cross aldol reaction of pyruvic acid and indole-3-pyruvic acid. The process comprises the step of reacting pyruvic acid with indole-3-pyruvic acid in the presence of an optically active α-amino acid containing a secondary amine and a metal ion. | 08-28-2008 |
20080262245 | Process for the Preparation of Amorphous Fluvastatin Sodium - The present invention relates to a novel process for the preparation of the HMG-CoA reductase inhibitor, fluvastatin, more specifically to a process for the preparation of amorphous form of fluvastatin sodium. | 10-23-2008 |
20100099891 | ESTIMATION OF PROTEIN-COMPOUND INTERACTION AND RATIONAL DESIGN OF COMPOUND LIBRARY BASED ON CHEMICAL GENOMIC INFORMATION - A data processing method for an estimation of compound-protein interaction using both chemical substance information, such as a chemical property of the compound, and biological information, such as sequence information of genes to rationally and efficiently screen compounds. First space representing space coordinates of a first chemical substance group and second space representing space coordinates of a second chemical substance group are defined, and the first chemical substance group is characterized by a first characteristic amount and the second chemical substance group is characterized by a second characteristic amount, and map transformation of the coordinates of the first space and the coordinates of the second space results in the solution so as to increase the correlation between the first space and the second space using a multivariable analysis technique or a machine learning method. | 04-22-2010 |
20120035373 | PROCESSES OF PRODUCING GLUTAMIC ACID COMPOUNDS AND PRODUCTION INTERMEDIATES THEREFORE AND NOVEL INTERMEDIATE FOR THE PROCESSES - The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products. | 02-09-2012 |
20120165548 | PROCESS FOR THE PREPARATION OF INDOLINE DERIVATIVES AND THEIR INTERMEDIATES THEREOF - Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent. | 06-28-2012 |
20140179932 | (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES - The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH | 06-26-2014 |
20150038727 | METHOD FOR PREPARING SILODOSIN - The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step, in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center, R | 02-05-2015 |
20160176818 | Method For Preparing Silodosin | 06-23-2016 |