Class / Patent application number | Description | Number of patent applications / Date published |
548373100 | Two double bonds between ring members of the diazole ring (i.e., pyrazole) | 80 |
20110028734 | PROCESSES FOR PRODUCING N-ALKYLPYRAZOLE - Processes are provided for combining nonsubstituted hydrazine (N2H4), a strong acid, alcohol, and tetraalkoxypropane to produce N-alkylpyrazole. | 02-03-2011 |
20130237710 | Process for the synthesis of halogenated cyclic compounds - A process for the manufacture of a cyclic compound of formula (I) | 09-12-2013 |
548374100 | Having -C(=X)-, wherein X is chalcogen bonded directly to the diazole ring | 61 |
20080262242 | Process For the Production of Carboxanilides - The present invention relates to a novel process for the preparation of a compound of general formula (I): wherein R | 10-23-2008 |
20080312452 | Phenoxypyrazole Composition and Process for the Solvent Extraction of Metals - A metal extractant comprising Formula (1) wherein R | 12-18-2008 |
20080319203 | Method for Producing 5-Fluoro-1,3-Dialkyl-1H-Pyrazol-4-Carboxylic Acid Chlorides - The present invention relates to a novel process for preparing known 5-fluoro-1,3-dialkyl-1H-pyrazole-4-carbonyl chlorides which can be used as starting materials for active fungicidal ingredients. | 12-25-2008 |
20090054660 | METHOD FOR PRODUCING CARBOXAMIDES - The present invention relates to a novel process for preparing known fungicidally active 1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamides from the corresponding acid fluoride and aniline derivatives in the absence of an acid acceptor. | 02-26-2009 |
20090054661 | Method for Producing Carboxamides - The present invention relates to a novel process for preparing known fungicidally active 1,3-dimethyl-5-fluoro- | 02-26-2009 |
20090069572 | PROCESS FOR THE PREPARATION OF PYRAZOLES - The present invention relates to a process for the preparation of compounds of formula I | 03-12-2009 |
20090209769 | Alkyl-Analide Producing Method - The present invention relates to a process for preparing known fungicidally effective alkylanilides from acid chlorides and aminoacetophenone via hydroxyalkyl-substituted carboxanilides, alkenylanilides and benzoxazine derivatives. | 08-20-2009 |
20090306401 | Method For The Production of 5-Fluoro-1,3-Dialkyl-1H-Pyrazol-4-Carbonyl Fluorides - The present invention relates to a novel process for preparing known 5-fluoro-1,3-dialkyl-1H-pyrazole-4-carbonyl fluorides which can be used as starting materials for active fungicidal ingredients by a halex reaction. | 12-10-2009 |
20090326242 | PROCESS FOR PREPARING 3-DIHALOMETHYL-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES - The invention relates to a process for preparing 3-dihalomethylpyrazole-4-carboxylic acid derivatives of the formula (I) by reacting α-fluoroamines of the formula (III) in the presence of Lewis acids with acrylic acid derivatives of the formula (II) to give vinamidinium salts of the formula (IV) and the subsequent reaction thereof with hydrazines, and to the vinamidinium salts of the formula (IV) themselves. | 12-31-2009 |
20100016612 | FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME, AND FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE OBTAINED BY USING THE FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME - The present invention provides a fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same, and a fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same. | 01-21-2010 |
20100022782 | Process for Preparing Fluoromethyl-Substituted Heterocyclic Compounds - The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I) | 01-28-2010 |
20100041899 | METHOD FOR PRODUCING SUBSTITUTED PYRAZOLECARBOXYLIC ACID CHLORIDES - The present invention relates to a process for preparing substituted pyrazolyl chlorides by chlorinating aldehydes of the formula (II) under free-radical conditions. | 02-18-2010 |
20100069646 | Process for preparing difluoromethylpyrazolyl carboxylates - The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula I | 03-18-2010 |
20100174093 | PROCESS FOR THE PRODUCTION OF PYRAZOLES - A process for the production of a compound of formula (I), which comprises a) reacting a compound of formula (II), wherein R | 07-08-2010 |
20100174094 | Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides - The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) | 07-08-2010 |
20100184994 | Method for Producing Difluoromethyl-Substituted Pyrazole Compounds - The present invention relates to a process for preparing 3-difluoromethyl-substituted pyrazole compounds of the formula (I) | 07-22-2010 |
20100204483 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES - The present invention relates to a process for preparing hydrochloride-free 2-dihaloacyl-3-aminoacrylic esters by reacting acid fluorides with dialkylaminoacrylic acid derivatives. | 08-12-2010 |
20100240907 | PROCESSES FOR THE PREPARATION OF PYRAZOLES - The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal′ are independently selected from Cl and F, and R | 09-23-2010 |
20110004002 | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates - A process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates (VI) | 01-06-2011 |
20110009642 | Method for the Regioselective Synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic Acid Derivatives - The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process. | 01-13-2011 |
20110015406 | METHOD FOR PRODUCING FLUORINE-CONTAINING ACYLACETIC ACID DERIVATIVE, METHOD FOR PRODUCING FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID ESTER DERIVATIVE, AND METHOD FOR PRODUCING FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE - A halogenating agent is added to a mixture including a base, a fluoroalkylcarboxylic acid derivative and an acrylate derivative to produce a fluoroaclyacetic acid derivative represented by the following Formula (3): | 01-20-2011 |
20110028735 | Process for the Regioselective Preparation of 1-Alkyl-3-haloalkylpyrazole-4-carboxylic Acid Derivatives - The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives with hydrazines in the presence of carbonyl compounds. | 02-03-2011 |
20110105766 | Method for Producing Substituted Biphenyls - A process for preparing substituted biphenyls of the formula I | 05-05-2011 |
20110118474 | Process for preparing 1,3-disubstituted pyrazolecarboxylic esters - A process for preparing 1,3-disubstituted pyrazolecarboxylic esters of the formula (I) | 05-19-2011 |
20110172436 | Method for preparing 1,3,4-substituted pyrazol compounds - The invention provides an Ethernet bridge or router comprising a network fabric adapted to provide interconnectivity to a plurality of Ethernet ports, each of the Ethernet ports being adapted to receive and/or transmit Ethernet frames, and wherein the Ethernet bridge or router further comprises an encapsulator connected to receive Ethernet Protocol Data Units from the Ethernet ports, wherein the encapsulator is operable to generate a Fabric Protocol Data Unit from a received Ethernet Protocol Data Unit, the Fabric Protocol Data Unit comprising a header portion, and a payload portion which comprises the Ethernet Protocol Data Unit concerned, and wherein the encapsulator is operable to transform Ethernet destination address information from the Ethernet Protocol Data Unit into a routing definition for the network fabric, and to include this routing definition in the header portion of the Fabric Protocol Data Unit. Also provided is a method of data delivery across a network. | 07-14-2011 |
20110178310 | PROCESS FOR THE PREPARATION OF AMIDES - The invention relates to a process for the preparation of fungicidally active compounds such as tricyclic amine derivatives (I). The process involves coupling of a carboxylic 5 acid e.g. a compound of formula (II) with an aniline, e.g. a compound of formula (III) in the presence of a boronic acid catalystor an antimony catalyst (II)(III)(I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Het are defined in the specification. | 07-21-2011 |
20110257410 | METHODS FOR THE PREPARATION OF FUNGICIDES - The present invention relates to methods of preparing compounds of formula (I) comprising the step of reacting the corresponding amide with the corresponding substituted aryl in the presence of a catalyst, which catalyst comprises copper and a ligand, Y is CHCHR | 10-20-2011 |
20110263869 | METHODS FOR THE PREPARATION OF ARYL AMIDES - The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherein the catalyst comprises copper and a ligand; comprising providing the compound of formula III in liquid form prior to contacting the compound of formula III with the catalyst. | 10-27-2011 |
20110288305 | Process for the preparation of 5-Fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl Chlorides and Fluorides - The present invention relates to a novel process for the preparation of 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl halides and the intermediates occurring in this process, ethyl 5-chloro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate and ethyl 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate. | 11-24-2011 |
20110301356 | Method for Producing 2-aminobiphenylene - The present invention relates to a process for preparing 2-aminobiphenyls of the formula I | 12-08-2011 |
20120041211 | NOVEL PROCESS FOR PREPARING CARBOXY-CONTAINING PYRAZOLEAMIDO COMPOUNDS 597 - A process for preparing pharmaceutically acceptable compounds of formula (I) | 02-16-2012 |
20120136162 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide. | 05-31-2012 |
20120203009 | PROCESSES RELATING TO THE ALKYLATION OF PYRAZOLES - The present invention relates to processes for the preparation of a compound of formula (I) comprising reacting a compound of formula (IV) with a compound of formula III or (IIIA) in the presence of an acid; wherein R | 08-09-2012 |
20120215009 | Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds - Process for preparing aminale and their use for preparing 1,3-disubstituted pyrazole compounds. | 08-23-2012 |
20120289707 | PROCESS FOR THE PREPARATION OF AMIDES - The invention relates to a process for the preparation of fungicidally active compounds such as tricyclic amine derivatives (I). The process involves coupling of a carboxylic acid e.g. a compound of formula (II) with an aniline, e.g. a compound of formula (III) in the presence of a boronic acid catalyst or an antimony catalyst | 11-15-2012 |
20130023668 | PROCESSES FOR THE PREPARATION OF PYRAZOLES - The present invention relates to novel processes for the production of compounds of formula | 01-24-2013 |
20130035495 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of formula (I) which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species to (III), wherein X is chloro or bromo; reacting the halobenzyne with a fulvene (IV), to a compound of formula (V) wherein X is chloro or bromo; b) hydrogenating V in the presence of a suitable metal catalyst to a compound of formula (VI) wherein X is chloro or bromo; and either c1) reacting the compound of formula VI with NH3 in the presence of a catalyst comprising palladium and at least one ligand to the compound of formula (VII); and d) reacting the compound of formula VII in the presence of a base with a compound of formula (VIII), to the compound of formula I; or c2 reacting the compound of formula (VI) in the presence of a copper catalyst and a ligand with the compound of formula (VIIIa), to the compound of formula (I). | 02-07-2013 |
20130035496 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of the compound of formula (I), which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species in an inert atmosphere to a halobenzyne of formula (X), reacting the halobenzyne of formula X so formed with cyclopentadiene to (III), b) reacting III in the presence of an inert solvent with an oxidant to (IV), c) reacing IV in the presence of a Lewis acid and a hydride source to (V), d) reacting V in the presence of an oxidizing agent, a base and an inert solvent to (VI), e) converting VI in the presence of a phosphane and CCL | 02-07-2013 |
20130041160 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of a compound of formula (I), which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species to (III) reacting the halobenzyne of formula (III) so formed with (IV) wherein R | 02-14-2013 |
20130041161 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES - The invention relates to a process for the preparation of formula (I), which process comprises a) reacting the compound (II), with cyclopentadiene to (III); b) reacting this compound in the presence of an oxidant to the compound of formula (IV); c) hydrogenating this compound in the presence of a metal catalyst and an inert solvent under hydrogen atmosphere to the compound of formula (V); d) reacting this compound in the presence of a Brönsted acid followed by a reducing agent to the compound of formula (VI); e) reacting VI with a compound (VII), in the presence of a base to a compound of formula (VIII); f) converting the compound of formula VIII in the presence of an oxidising agent to the compound of formula (IX); and g) reacting the compound of formula IX in the presence of triphenylphosphane/carbon tetrachloride or triphenylphosphane/bromotrichloromethane to the compound of formula I. | 02-14-2013 |
20130123510 | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids - A process for the manufacture of an ester or the respective free acid of a 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acid of formula (I), wherein in such formula (I), Y is H, F or an alkyl group having from 1 to 12 carbon atoms which is optionally substituted by at least one halogen atom, an aralkyl group or an aryl group; R | 05-16-2013 |
20130197239 | Method for the Regioselective Synthesis of 1-Alkyl-3-Haloalkyl-Pyrazole-4-Carboxylic Acid Derivatives - The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process. | 08-01-2013 |
20130197240 | PROCESS FOR PREPARING AMINOADAMANTYL CARBAMATE DERIVATIVES - Disclosed is a process for producing an aminoadamantane carbamate derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. | 08-01-2013 |
20130225833 | Process for the preparation of pyrazole-4-carboxamides - A process for the manufacture of pyrazole-4-carboxamides, in particular, of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamides which are useful as pharmaceuticals and agrochemicals. The carboxamides are prepared from the corresponding pyrazole-4-carboxylic acid esters and appropriate amine in the presence of a base. The reaction is performed in a reaction medium which is essentially free of water; alternatively, the base is used in an amount equal to or greater than 0.25 equivalents per mole of amine. | 08-29-2013 |
20140081030 | O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES AND THEIR USE AS FUNGICIDES - The present invention relates to O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES derivatives of formula (I); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. | 03-20-2014 |
20140107347 | Method for Producing Pyrazole Compound - A method for producing a pyrazole compound of the general formula (5) includes reacting a 2-acyl-3-aminoacrylic acid ester of the general formula (1) with a hydrazine of the general formula (4) in the presence of a base | 04-17-2014 |
20140107348 | METHODS FOR THE PREPARATION OF ARYL AMIDES - The present invention relates to methods of initiating a reaction represented by scheme 1 | 04-17-2014 |
20140128617 | METHOD FOR PRODUCING PYRAZOLYLCARBOXANILIDES - The present invention relates to a simplified process for preparing pyrazolylcarboxanilides by reacting pyrazolylcarboxylic esters with anilines in the presence of a base and removing at least one reaction product. | 05-08-2014 |
20140148603 | Method for preparing a fluorinated organic compound - A method for preparing a fluorinated organic compound (II) from an organic compound (I) comprising at least one nucleofugal group Nu, and also a preparation of different specific organic compounds, in particular a fluoro-methylpyrazole compound. The method comprises: a reaction, in the presence of water, of the organic compound (I) and at least one salt providing at least one fluoride anion; and a replacement of at least one nucleofugal group Nu of the compound (I) with a fluorine atom, in order to obtain the fluorinated organic compound (II). | 05-29-2014 |
20140221669 | PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER - The present disclosure provides a novel and economically advantageous process for preparation of compounds of Formula I, such as alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester. The process includes acidification of the sodium enolate of alkyl difluoroacetoacetate by carbonic acid generated in situ by reacting carbon dioxide with water. The disclosure also includes promoting the ring closure reaction in which alkyl 2-alkomethylene-4,4-difluoro-3-oxobutyrate is reacted with methylhydrazine in two phase system with a weak base such as Na | 08-07-2014 |
20140364622 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE CARBOXAMIDE - The present invention relates to a process for the enantioselective preparation of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ((1S,4R)-9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide of formula Ib. | 12-11-2014 |
20150011779 | METHOD FOR PRODUCING 3,5-BIS(FLUOROALKYL)-PYRAZOL-4-CARBOXYLIC ACID DERIVATIVES AND 3,5-BIS(FLUOROALKYL)-PYRAZOLES - The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and 3,5-bis(fluoroalkyl)pyrazoles. | 01-08-2015 |
20150018562 | PROCESS FOR THE PREPARATION OF PHENYL SUBSTITUTED 3 - DIFLUOROMETHYL - 1 -METHYL - 1H - PYRAZOLE - 4 - CARBOXYLIC ACID N-METHOXY- [1 -METHYL- 2 PHENYLETHYL] AMIDES - The invention relates to a process for the preparation of a compound of formula (I), wherein R | 01-15-2015 |
20150126748 | PROCESS FOR PREPARING 1-ALKYL-3-FLUOROALKYL-1H-PYRAZOLE-4-CARBOXYLIC ACID CHLORIDES - The present invention relates to a novel method for preparing 1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides, a useful precursor for the preparation of fungicides, by means of reductive dehalogenation, starting from N-alkyl-3-haloalkyl-5-halopyrazolecarbaldehyde. | 05-07-2015 |
20150353501 | PROCESS FOR THE PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE AND ITS ANALOGS - The disclosure provides a process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs. The process includes a reaction workup method for Claisen condensation, wherein the enolate salt is acidified after removing remaining starting material and byproducts such as, ethanol and excessive ethyl acetate. The process also includes a method for completely drying alkyl difluoroacetoacetate and its analogs before use in the next step by reacting trialkyl orthoformate with the residual water. The process includes using Na | 12-10-2015 |
20150353502 | PROCESS FOR PREPARING 5-FLUORO-1-METHYL-3-DIFLUOROMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE - The present invention relates to a novel process for preparing 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbaldehyde, a useful intermediate in the manufacture of fungicides. | 12-10-2015 |
20160009655 | METHOD FOR PRODUCING CARBOXAMIDES | 01-14-2016 |
20160068491 | COMPOUNDS AS TYROSINE KINASE MODULATORS - The present invention provides a compound, that is | 03-10-2016 |
20160108001 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE - The present invention relates to a process for the enantioselective preparation of the compound of formula (Ib), which process comprises a) reducing the (E)- or (Z)-form of a compound of formula (II), with an enantioselective reagent to a compound of formula (IIIa), and b) acylating the compound of formula (IIIa) with the compound of formula (IV), or c) coupling the compound of formula (IV) with the compound of formula (II), to give a compound of formula (V) and d) reducing compound of formula (V) in the presence of hydrogen, a catalyst and a chiral ligand, to the compound of formula (Ib). | 04-21-2016 |
20160122304 | METHOD FOR THE PRODUCTION OF 3,5-BIS(FLUOROALKYL)PYRAZOLE DERIVATIVES - The present invention describes a novel method for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives. | 05-05-2016 |
20160185731 | METHOD FOR PRODUCING 3,5-BIS(FLUOROALKYL)-PYRAZOL-4-CARBOXYLIC ACID DERIVATIVES AND 3,5-BIS(FLUOROALKYL)-PYRAZOLES - The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and 3,5-bis(fluoroalkyl)pyrazoles. | 06-30-2016 |
548375100 | Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding | 4 |
20080234491 | PROCESS FOR PREPARATION OF CELECOXIB - There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purification of celecoxib using aromatic hydrocarbon solvents. | 09-25-2008 |
20090062552 | PROCESS FOR THE PREPARATION OF A CARBOXAMIDE DERIVATIVE - Process for the preparation of a carboxamide derivative of formula (I) or a salt thereof | 03-05-2009 |
20140364623 | PROCESS FOR PREPARING ACETANILIDES - The present invention relates to a novel process for preparing acetanilides of the formula (I) | 12-11-2014 |
20140371467 | GLUCAGON RECEPTOR MODULATORS - The present invention provides a compound of Formula (I) | 12-18-2014 |
548376100 | Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding | 3 |
20130289283 | FIPRONIL PRODUCTION PROCESS - An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid. | 10-31-2013 |
20150290172 | THERAPEUTIC AGENT FOR KERATOCONJUNCTIVE DISORDERS - The present invention addresses the problem of providing a novel therapeutic agent for keratoconjunctive disorders. As a means for solving the problem, a therapeutic agent for keratoconjunctive disorders which contains a RARγ agonist as an active ingredient is provided. The therapeutic agent exhibits an excellent ameliorating effect in a keratoconjunctive disorder model, and is therefore useful as a therapeutic agent for keratoconjunctive disorders such as corneal ulcer, corneal epithelial abrasion, keratitis, dry eye, conjunctivitis, chronic superficial keratitis, corneal erosion, persistent corneal disorders, superficial punctate keratopathy, corneal epithelial defects, conjunctival epithelial defects, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, filamentary keratoconjunctivitis, infectious keratitis, noninfectious keratitis, infectious conjunctivitis and noninfectious conjunctivitis. The therapeutic agent is also useful as a therapeutic agent for corneal scarring and conjunctival scarring both associated with keratoconjunctive disorders. | 10-15-2015 |
20150376135 | PROCESS FOR THE PREPARATION OF BIS-DIHALOALKYL PYRAZOLES - The present invention relates to a process for the preparation of bisdihaloalkyl pyrazoles of formula (V) starting from diketones and acylhalides reacted with a Lewis acid, and a subsequent reaction with a substituted hydrazine. | 12-31-2015 |
548377100 | Benzene ring bonded directly to the diazole ring | 10 |
20090054662 | Process for synthesizing a substituted pyrazole - The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus. | 02-26-2009 |
20090240061 | Method for forming a carbon-carbon or carbon-heteroatom bond - The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C—C or C—HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent. | 09-24-2009 |
20100121076 | METHOD FOR THE PREPARATION OF PHOSPHINE BUTADIENE LIGANDS, COMPLEXES THEREOF WITH COPPER AND USE THEREOF IN CATALYSIS - The present invention relates to a method for preparing phosphine butadiene-type ligands, and their use, particularly as catalytic metal ligands used in the reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds. | 05-13-2010 |
20100184995 | PROCESS FOR THE PRODUCTION OF A CRYSTALLINE GLUCAGON RECEPTOR ANTAGONIST COMPOUND - The present invention relates to a process for the production of crystalline particles of a glucagon receptor antagonist compound. The process includes the steps of generating microseeds and subjecting the microseeds to a crystallization process. The resulting crystalline particles have a mean particle size of less than about 100 mm. The present invention also provides for a pharmaceutical composition which includes the crystalline particles produced by the method described herein and a pharmaceutically acceptable carrier. | 07-22-2010 |
20100267964 | N-HETEROCYCLYLPHENYL-SUBSTITUTED CYCLIC KETOENOLS - The invention relates to novel intermediates for the preparation of N-heterocyclylphenyl-substituted cyclic ketoenols of the formula (I) | 10-21-2010 |
20110213159 | PROCESS FOR PREPARATION OF CELECOXIB CRYSTALLINE FORM - Celecoxib crystalline Form Ill substantially free of celecoxib crystalline Forms I and II and a process for its preparation. | 09-01-2011 |
20120029205 | Hydrated Sodium Salt Form of Celecoxib - Hydrated celecoxib sodium salt forms and processes to prepare hydrated celecoxib sodium salt forms are disclosed. The celecoxib sodium salt forms are particularly useful and suitable for pharmaceutical applications. | 02-02-2012 |
20120108823 | ANTI-FRANCISELLA AGENTS - A series of celecoxib derivatives defined by Formula I: | 05-03-2012 |
20130165667 | METHOD FOR THE PREPARATION OF PHOSPHINE BUTADIENE LIGANDS, COMPLEXES THEREOF WITH COPPER AND USE THEREOF IN CATALYSIS - A method for the creation of a carbon-carbon (C—C) bond or of a carbon-heteroatom (C-HE) bond includes reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) capable of replacing the leaving group, thus creating a C—C or C-HE bond, in which process the reaction is carried out in the presence of an effective amount of a catalytic system comprising at least one copper/butadienylphosphine complex. | 06-27-2013 |
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