Class / Patent application number | Description | Number of patent applications / Date published |
540470000 | The hetero ring contains plural nitrogens | 31 |
20100160626 | Process For The Preparation Of 3,7-Dihydroxy-1,5-Diazacyclooctanes - There is provided processes for the preparation of various compounds, including compounds of formulae I, IV and VII, | 06-24-2010 |
20150322079 | LOW CATALYST LOADING IN METATHESIS REACTIONS - The present invention relates to a method for producing metathesis products comprising contacting metathesis starting materials under metathesis conditions with a metathesis catalyst, wherein the metathesis catalyst is employed in an amount of from 0.0001 mol-% to 1 mol-% based on half of the sum of the reactive double bonds of the metathesis starting materials and wherein the ethylene or propylene generated in the course of the reaction is removed from the reaction mixture. | 11-12-2015 |
540471000 | Polycyclo ring system which contains the hetero ring as one of the cyclos | 10 |
20100041880 | Supramolecular Scaffolds and Methods of Making the Same - Tribenzo-1,4,7-triazacyclononane and derivatives thereof having a formula (I) are disclosed. Methods of making tribenzo-1,4,7-triazacyclononane and related compounds also are disclosed. | 02-18-2010 |
20110160450 | EXPLOSIVE - The invention relates to an explosive comprising 2,6,10-trinitro-s-heptazine and/or derivatives thereof as an active chemical compound. | 06-30-2011 |
20140213781 | CYCLIC TRIPEPTIDE MIMETICS AS PLASMIN INHIBITORS - The invention relates to peptide mimetics comprising the residues P4-P3-P2-P1, which were cyclized between the side chains of P3 and P2 amino acid and are, as inhibitors of the serine protease plasmin, suitable to be used to inhibit fibrinolysis and thus to reduce blood loss in hyperfibrinolytic conditions, for example during surgery. | 07-31-2014 |
540472000 | Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc., toxiferin) | 7 |
20080293932 | PHTHALOCYANINE RECORDING LAYER OF OPTICAL RECORDING MEDIA - A phthalocyanine compound of formula (I) is provided for use in a recording layer of an optical recording media. | 11-27-2008 |
20120123113 | DI-SUBSTITUTED PYRIDINUM POLYMERS AND SYNTHESIS THEREOF - A method of producing a di-substituted pyridinium polymer by microwave-assisted polymerisation of a 2, 3, or 4-substituted pyridine monomer of the formula NC | 05-17-2012 |
20120238748 | NOVEL COMPOUNDS HAVING PHENANTHROLINE STRUCTURE - The present invention provides a novel compound having a phenanthroline structure represented by formula (I) or a salt thereof: | 09-20-2012 |
20130066068 | PHOTO-RESPONSIVE LIQUID CRYSTALLINE COMPOUND AND ITS APPLICATIONS - The purpose of the present invention is to provide novel liquid crystalline compounds that are capable of inducing phase transition by a light stimulus and are useful in the display, optoelectronics, and photonics field. The present invention relates to the liquid crystalline compounds represented by general formula (1): | 03-14-2013 |
20140206861 | Antioxidant Small Molecules Aimed at Targeting Metal-Based Oxidative Stress in Neurodegenerative Disorders - Amine chelates capable of antioxidant capacity and amyloid disaggregation are shown which may be useful in targeting metal-based oxidative stress in neurodegenerative disorders. Pyclen, a backbone commonly investigated for contrast agent imaging, may be repurposed as an anti-oxidant chelator for disaggregating amyloid. The antioxidant capacity of pyclen was enhanced dramatically via conversion of the pyridine backbone to a pyridol with cellular studies showing superior antioxidant capacity while retaining chelation ability to protect amyloid from metal ions aggregation and also disaggregate amyloid aggregates. | 07-24-2014 |
20140206862 | Antioxidant Small Molecules Aimed at Targeting Metal-Based Oxidative Stress in Neurogenerative Disorders - Amine chelates capable of antioxidant capacity and amyloid disaggregation are shown which may be useful in targeting metal-based oxidative stress in neurodegenerative disorders. Pyclen, a backbone commonly investigated for contrast agent imaging, may be repurposed as an anti-oxidant chelator for disaggregating amyloid. The antioxidant capacity of pyclen is enhanced dramatically via conversion of the pyridine backbone to a pyridol with cellular studies showing superior antioxidant capacity while retaining chelation ability to protect amyloid from metal ions aggregation and also disaggregate amyloid aggregates. Another family of molecules based upon hybrid heterocyclic amine ligands is also presented. | 07-24-2014 |
20150291608 | NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF - Provided are a cross-bridged tetraaza macrocyclic compound of a novel structure that can be used, for example, as a contrast agent for diagnostic imaging or a radiopharmaceutical and a method for preparing the same. | 10-15-2015 |
540474000 | The hetero ring contains at least three nitrogens | 19 |
20080312430 | Method of Preparing or Synthesizing Polyazamacrocycle Derivatives - The present invention relates to novel processes for the synthesis of polyazamacrocycle derivatives. Furthermore, the present invention relates to novel polyazamacrocycle derivatives as well as novel intermediates for the synthesis of said polyazamacrocycle derivatives. | 12-18-2008 |
20080312431 | Responsive Luminescent Lanthanide Complexes - The invention provides a compound comprising a xanthone or thiaxanthone sensitising moiety, capable of coordinating to a lanthanide ion by the nitrogen atom of an integral pyridyl group or a related group able to bind a lanthanide ion. | 12-18-2008 |
20090036674 | Metal Complexes of Tetraazamacrocycle Derivatives - Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof. | 02-05-2009 |
20090216011 | Synthesis of cyclen derivatives - The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure giving DO3A-tri-t-butyl ester as a salt of excellent purity. | 08-27-2009 |
20100056776 | METHOD OF PREPARING MACROMOLECULAR CONTRAST AGENTS AND USES THEREOF - Disclosed are methods of preparing a macromolecular conjugated ligand and a metal complex thereof. The metal complex is targeted for use as a contrast agent, for example, in MRI. The method of preparing a macromolecular conjugated ligand comprises: (a) providing a compound of formula (I) | 03-04-2010 |
20100184972 | SYNTHESIS OF DEOXYBIOTINYL HEXAMETHYLENEDIAMINE-DOTA - A process for the synthesis of deoxybiotinyl hexamethylenediamine0-DOTA is herein described. Said process comprises reacting biotinyl hexamithylenediamine with tri-t-butyl DOTA in the presence of benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, as the condensing agent, and triethylamine, as a base. | 07-22-2010 |
20110028714 | FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF - A cell population expressing folate receptors is selectively targeted with a folate mimetic. The folate mimetic is conjugated to a diagnostic or therapeutic agent to enable selective delivery of the agent to the targeted cell population. | 02-03-2011 |
20120277421 | Metal Complexes of Tetraazamacrocycle Derivatives - Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof. | 11-01-2012 |
20120309962 | PROCESS FOR THE PREPARATION OF CALCOBUTROL - The invention concerns a process for the preparation of the calcium complex of 0-(2,3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclodecane-4,7-triacetic acid, also known as Calcobutrol, starting from the pure gadolinium complex (Gadobutrol). The invention furthermore concerns Calcobutrol with a hitherto unknown level of purity. | 12-06-2012 |
20130261297 | 1,2-BIS-(4,7-DIMETHYL-1,4,7-TRIAZACYCLONON-1-YL)-ETHANE AND INTERMEDIATE FOR THE SYNTHESIS OF SAME - The present invention provides improved processes for the synthesis of 1,4-ditosyl-1,4,7-triazacyclonone and protected analogues thereof, and to synthesise bis(triazacyclononane) ligands. | 10-03-2013 |
20130310555 | SYNTHESIS OF THERAPEUTIC AND DIAGNOSTIC DRUGS CENTERED ON REGIOSELECTIVE AND STEREOSELECTIVE RING OPENING OF AZIRIDINIUM IONS - Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds. | 11-21-2013 |
20140323719 | PROCESS FOR THE PURIFICATION OF POLYAMINOCARBOXYLATES - The present invention relates to an improved process for the purification of polyaminocarboxylates such as DOTA, DTPA, DO3A-butrol, BOPTA. | 10-30-2014 |
20140336373 | NOVEL COMPLEXING AGENTS AND CORRESPONDING LANTHANIDE COMPLEXES - The present invention concerns complexing agents of formula (I) in which a, b, c, chrom | 11-13-2014 |
20150094465 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 04-02-2015 |
20150307524 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules - The present application discloses compositions and methods of synthesis and use of | 10-29-2015 |
20160002121 | METHODS AND COMPOSITIONS FOR RADIOHALOGEN PROTEIN LABELING - Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [ | 01-07-2016 |
20160185737 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 06-30-2016 |
540475000 | Nitro bonded directly to ring nitrogen of the hetero ring (e.g., HMX, etc.) | 2 |
20120149896 | METHOD FOR SEPARATION OF HMX AND RDX - The present invention is directed to a method for effectively separating HMX and RDX from HMX/RDX-included explosives, respectively, without using a harmful organic solvent, the method capable of respectively separating HMX and RDX from HMX/RDX-included explosives by selectively dissolving RDX included in explosives by using a difference between solubility parameters of HMX and RDX with respect to compressed dimethylether. The present invention is further directed to an apparatus for respectively separating HMX and RDX from HMX/RDX-included explosives comprising a dimethylether supplying unit, an explosive particle dissolving unit, and an explosive particle collecting unit. | 06-14-2012 |
20150080567 | Method to Produce and Scale-Up Cocrystals and Salts Via Resonant Acoustic Mixing - A method to produce and manufacture cocrystals and salts is disclosed wherein crystalline solids and other components were combined in the desired proportions into a mixing chamber and mixed at high intensity to afford a cocrystalline product. No grinding media were required. The mixing system consists of a resonant acoustic vibratory system capable of supplying a large amount of energy to the mixture and is tunable to a desired resonance frequency and amplitude. The use of resonant acoustic mixing to assist cocrystallization is novel. This discovery enables the manufacture of cocrystals and salt forms, simplifying their manufacture and scale-up, and avoiding the use of grinding methods or grinding media. The present invention affords the manufacture of cocrystals and salts on kilogram to multi-ton scale and is adaptable to continuous manufacturing through the use of resonant mixing methods. | 03-19-2015 |