Class / Patent application number | Description | Number of patent applications / Date published |
530408000 | Sulfur containing reactant | 15 |
20080249287 | Refolding Transforming Growth Factor Beta Family Proteins - Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product. | 10-09-2008 |
20080249288 | Methods for Chemically Synthesizing Immunoglobulin Chimeric Proteins - The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule. | 10-09-2008 |
20090192300 | Side-Chain Extended Ligation - The invention is directed to methods and compositions for chemical ligation of a first component that includes a carboxythioester and a second component that includes an amino-functionalized compound bearing a branched side chain that includes a removable thiol auxiliary, to give a ligation product having an amide bond at the ligation site. The reactants of the invention are chemoselective and the thiol moiety is removable from the ligation product. Removal of the thiol can be exploited to generate a native side chain at the ligation site. The methods and compositions of the invention are particularly useful for ligation of peptides and polypeptides. The ligation system of the invention is applicable to a wide variety of molecules, and thus can be exploited to generate peptides, polypeptides and other amino acid containing polymers. | 07-30-2009 |
20100204459 | SYSTEMS AND METHODS FOR PRODUCING MULTI-COMPONENT COLLOIDAL STRUCTURES - A system for producing multi-component colloidal structures has a supply system; an assembly system that is in fluid connection with the supply system to receive a supply of colloidal structural components from the supply system; and an output system in fluid connection with the assembly system. The assembly system has an assembly chamber adapted to contain colloidal structural components during assembly of a multi-component colloidal structure and is structured and arranged to control positions and orientations of first and second c structural components in the assembly chamber to bring the first and second colloidal structural components together in predetermined relative positions and orientations for assembly into at least a portion of the multi-component colloidal structure. | 08-12-2010 |
20110034678 | METHODS OF RENATURATION OF RECOMBINANT PROTEINS - The present invention provides large-scale methods for renaturation of proteins comprising adding a solution of denatured, chemically modified or reduced proteins to a refolding buffer containing sulfate derived from H | 02-10-2011 |
20110092678 | SINGLE-LABELLING AGENTS BASED ON VINYL SULPHONE - The invention relates to labelling agents containing a compound with a labelled molecule and a vinyl sulphone group. The invention also relates to the compounds, the method for obtaining them and the uses thereof in the marking of biomolecules and, more specifically, proteins. | 04-21-2011 |
20110288280 | COELENTERAMIDE ANALOGS - There has been a need for coelenteramide analogs or the like that produce fluorescent proteins which exhibit different fluorescent characteristics from those of the existing fluorescent proteins. Disclosed is a compound represented by general formula (1) (wherein R | 11-24-2011 |
20130184444 | COMPACT NANOPARTICLES FOR BIOLOGICAL APPLICATIONS - A water soluble nanoparticle can include a ligand of formula (I). The ligand can provide zwitterionic character and can provide water solubility, small hydrodynamic diameter, chemical stability, and the capability to modify the nanoparticle with additional functional moieties such as a small molecule, nucleic acid, or protein. | 07-18-2013 |
20130211055 | DITHIOAMINE REDUCING AGENTS - Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins. | 08-15-2013 |
20140039167 | Polymer Derivatives Comprising an Acetal or Ketal Branching Point - The invention conjugates that can be prepared by contacting a polymer comprising an acetal or ketal branching point with a pharmacologically active agent under conditions suitable to form a covalent attachment between the polymer and the pharmacologically active agent. | 02-06-2014 |
20140046040 | Method For Selective Derivatization of Oligohistidine Sequence of Recombinant Proteins - Methods and compositions for the selective derivatization of a oligohistidine-tagged recombinant protein. A modifying compound comprised of an imidazole reactive group, a linker, and a ligating group is contacted with the recombinant protein, and a cooperative bond forms between the ligating group and the oligohistidine tag in the presence of a metal cation, and a covalent bond forms between the imidazole reactive group and an imidazole ring of the oligohistidine tag followed by the concomitant separation of the imidazole reactive group from the linker. Addition of a metal chelator results in the dissociation of the ligating group and the oligohistidine tag. | 02-13-2014 |
20140058070 | C-TERMINAL AMIDATION OF POLYPEPTIDES - There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C-terminal of the polypeptide. In the subsequent step, the auxiliary molecule is removed from the C-terminal of the polypeptide adduct under conditions suitable to produce an amidated polypeptide. | 02-27-2014 |
20150038686 | Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites - The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided. | 02-05-2015 |
20160039868 | PROCESS FOR ISOLATION AND STABILISATION OF KEY INTERMEDIATES FOR HIGH EFFICIENCY REFOLDING OF RECOMBINANT PROTEINS - A process for obtaining a refolded recombinant protein from an unfolded recombinant protein present in inclusion bodies isolated from wet cells harvested from a cell culture is provided. The process includes a) reducing the inclusion bodies by treating the inclusion bodies with a reducing buffer, to obtain reduced inclusion bodies; b) obtaining stable first intermediate state I | 02-11-2016 |
20160052878 | ORGANOCATALYSTS OF OXIDATIVE PROTEIN FOLDING - Catalysts of protein-disulfide isomerization of formula: | 02-25-2016 |