Class / Patent application number | Description | Number of patent applications / Date published |
530356000 | Collagen | 69 |
20080293919 | Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Composite Materials - The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation. | 11-27-2008 |
20090023899 | DEFATTING COLLAGEN - Pig rind is one source of collagen for processing into products, such as sausage casings and films. However, it has a high fat content. The invention produces a defatted collagen paste from a collagen source by cutting the collagen into pieces, pressurising the collagen pieces to squeeze out fat and disintegrating the defatted pieces to form a fibrous paste. The paste can be used to produce a gel, which may be extruded to produce a collagen product. | 01-22-2009 |
20090030184 | Expression system for producing collagen - A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems and methods for the expression of the DNA molecule are also provided. | 01-29-2009 |
20090069540 | STRETCHABLE COLLAGEN MATERIAL AND MANUFACTURING METHOD AND USE THEREOF - The present invention provides a stretchable collagen material, particularly collagen derived from fishes, having excellent stretching property and mechanical strength, which can be widely used as a cell carrier and medical material, and to a method for manufacturing the same. By thermally treating a gel comprising collagen fiber cross-linked by using cross-linking agent, the collagen enhanced in both stretching property and mechanical strength can be produced. The stretchable collagen material is extremely useful as a cell carrier material and medical material. | 03-12-2009 |
20090149634 | POROUS BODY COMPRISING APATITE/COLLAGEN COMPOSITE FIBERS AND ITS PRODUCTION METHOD - A porous body comprising apatite/collagen composite fibers, which has a half-value period of strength of 0.8-1.6 hours, the half-value period of strength being the time until the strength of the porous body of 10 mm×10 mm×4 mm comprising apatite/collagen composite fibers is reduced to half, after the porous body degassed by pressure reduction to 3 kPa (absolute pressure) for 10 minutes in a phosphate buffer saline is given a 20-% strain at a speed of 10 mm/minute. | 06-11-2009 |
20090264625 | Method for recombinant microorganism expression and isolation of collagen-like polypeptides - A composition comprising a purified collagen-like polypeptide suitable as a peptizer, said polypeptide comprising [Gly-X-Y]n repeats, wherein Gly stands for glycine, X and Y represent any amino acid and n is an integer and selected such that the length of the [Gly-X-Y]n repeat is at least 2.5 kDa and wherein the amino acid sequence of said [Gly-X-Y]n repeats comprises more than 4 different amino acids and wherein said purified polypeptide is free of helix structure. | 10-22-2009 |
20090264626 | STABILIZATION OF THE COLLAGEN TRIPLE HELIX BY O-METHYLATION OF HYDROXYPROLINE RESIDUES - This invention relates to a collagen polypeptide comprising a tripeptide motif having the formula (ProYaaGly) | 10-22-2009 |
20090312524 | COMPOSITIONS AND METHODS COMPRISING COLLAGEN - In various embodiments, a collagen product is provided that is derived from an animal, the collagen product comprises precipitated collagen that is substantially pure. In various embodiments, the collagen is obtained from a marine animal and does not contain prions or viruses. In various embodiments, the collagen can be made or incorporated into collagen films, collagen membranes, cosmetic collagen masks, collagen sponges, gelatin, hemostasis sponges, lyophilized foams, collagen injections, artificial skins and dura, bones, cartilage, screws, shafts, stems, or tube guides. | 12-17-2009 |
20100036098 | BIOCOMPOSITES AND METHODS OF MAKING THE SAME - In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making. | 02-11-2010 |
20100063253 | Long-Lasting Collagen and Manufacturing Method thereof - In a long-lasting collagen and its manufacturing method, a pig skin is gone through processes of scraping extra tissues, removing fats, imbibition, digesting, centrifugal separation, salting-out, collecting lower-layer precipitate and freeze-drying to form a collagen, and the collagen is mixed with γ-PGA, and then a glutaraldehyde solution is added and mixed uniformly to perform a first crosslinking and form the long-lasting collagen, so as to overcome the shortcomings of a conventional collagen having a short storage time, a requirement of applying the collagen repeatedly, and a high concentration of remained glutaradldehyde which is biologically poisonous to human bodies. | 03-11-2010 |
20100210822 | MODIFIED RECOMBINANT HUMAN ENDOSTATIN AND USES THEREOF - Provided is a kind of modified recombinant human endostatin that has the structure of CH | 08-19-2010 |
20100280226 | Method for using nano carbon to refine collagen into nanoparticulate collagen - This invention relates to a method of using nano carbon to refine collagen into nanoparticulate collagen. As nano carbon particle are mixed into collagen, the pored structure of the nano carbon absorb and adhere to the collagen outer cell membrane and subsequently tears the collagen apart into nanoparticulates via ultrasound vibration, Thus it creates an advanced nanoparticulate collagen small enough to be practically and efficiently absorbed by the skin when applied directly. | 11-04-2010 |
20100311949 | ALIGNED COLLAGEN AND METHOD THEREFOR - Compositions and methods of preparing a graft construct comprising aligned collagen fibrils, wherein the construct is anisotropic, are described. The construct is prepared by application of an electrochemical field and a pH gradient to solutions containing collagen. In accordance with this method, collagen aligns at its isoelectric point to form anisotropic constructs. | 12-09-2010 |
20110003970 | MULTI BLOCK COPOLYMERS - A multi-block copolymer comprises at least one hydrophilic collagen-like block and at least one silk-like block. The silk-like block comprises an amino acid sequence ((GA) | 01-06-2011 |
20110021753 | Method for Preparing Porous Collagen Matrices - A method of preparing porous collagen matrices directly from connective tissues using an acidic solution substantially free of salt. | 01-27-2011 |
20110021754 | BIOPOLYMERIC MEMBRANES - This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric. | 01-27-2011 |
20110060129 | NONCOVALENT COLLAGEN CROSSLINKING AGENT - An object of the invention is to provide a collagen crosslinking agent superior in biocompatibility that is free from the damage by UV irradiation and also from the problems of toxicity caused by residual monomer or unreacted functional groups. | 03-10-2011 |
20110077382 | Collagen Peptide Having Immune-enhancing Activity from Cyanea Nozakii and Preparation Method and Uses Thereof - A collagen peptide with immune-enhancing activity from Cyanea nozakii, and a preparation method thereof are provided. The collagen peptide contains 80-90 wt % of proteins and 10-20 wt % of sugars, and has an average molecular weight of 1,000-3,000. Monosackcharides contained in the collagen peptide are mainly glucose, glycine accounts for 16% or above and the sum of praline and hydroxyproline accounts for 18% or above of amino acids contained therein. The collagen peptide is capable of being used for preparation of medicines, health products, and skincare cosmetics having immune-enhancing function. | 03-31-2011 |
20110137013 | NOVEL COLLAGEN-LIKE PROTEIN CLAC, PRECURSOR THEREOF AND GENES ENCODING THE SAME - A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same. | 06-09-2011 |
20110166325 | COLLAGEN FIBRILLAR CONSTRUCTION - Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering. | 07-07-2011 |
20110245466 | METHOD OF PRODUCTION OF POLYANIONIC DRUG-CARRIER CONJUGATES - The invention concerns the method of production of a polyanionic macromolecule which is a protein built, among others, form polar amino acids (such as lysine, arginine, aspartic acid, glutamic acid), characteristic in that, that as a result of the reaction between amine groups and the cyclic anhydride of dicarboxylic acid, the charge changes towards more negatively charged carrier. This reaction gives rise to better therapeutic properties of macromolecules modified in this way. | 10-06-2011 |
20110288274 | Designer collagens and use thereof - The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one ‘inserted’ biologically active sequence(s). | 11-24-2011 |
20110306754 | Aligned Polymers Including Bonded Substrates - The present disclosure relates to the present disclosure relates to a method of fabricating an aligned polymer containing a bonded substrate and related compositions. The method involved placing a polymer in solution which is capable of alignment wherein the polymer is also bound to a selected substrate. This may then be followed by placing the polymer solution in an electrochemical cell wherein the polymer solution is in contact with at least one electrode and applying an electric field/voltage to the polymer solution and generating a pH gradient wherein the polymer and bonded substrate positions at the isoelectric point of the polymer in solution. | 12-15-2011 |
20110306755 | HUMAN PLACENTAL COLLAGEN COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. | 12-15-2011 |
20120022233 | COLLAGEN IMPLANT - The invention relates to a highly pure collagen, its use as an implant and a method for its preparation, the method comprising subjecting a sample comprising collagen to at least one alkaline treatment step in an alkaline solution at a pH>12 and at least one cleaning step with at least one chaotropic agent. | 01-26-2012 |
20120059152 | PROTEIN SUBSTANCE HAVING TRIPLE HELIX STRUCTURE AND MANUFACTURING METHOD THEREFOR - As a result of dedicated research, the present inventors have successfully invented a collagen gene construct which can be easily purified and maintains a triple helix structure equivalent to that of naturally-occurring collagen while having a low molecular weight. Specifically, one-step purification by affinity purification is enabled because CR-D (a signal peptide) has a carbohydrate recognition domain. By substituting a portion of a human collagen structural gene of the present invention with the collagen-like structural gene portion of MBL, a low-molecular-weight collagen which maintains a triple helix structure and is thermally stable can be obtained with high purity and in large quantities. | 03-08-2012 |
20120065376 | METHODS OF PROCESSING RECOMBINANT PROCOLLAGEN - A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed. | 03-15-2012 |
20120172577 | METHODS OF PRODUCING PROTEINS HAVING TRIPLE-HELIX STRUCTURE - An objective of the present invention is to provide methods of producing human collagen molecules that are easy to isolate and purify and that have a structure substantially equivalent to that of a natural collagen molecule, wherein host cells that are transduced with a collagen gene synthesize large amounts of human collagen protein derived from a gene introduced into a high exogenous gene expression vector. Another objective of the present invention is to provide collagen molecules produced by the production methods. | 07-05-2012 |
20120245327 | TRANSFORMANT WHICH PRODUCES COLLAGEN WHEREIN BOTH LYSINE RESIDUE AND PROLINE RESIDUE ARE HYDROXYLATED - Disclosed is a transformant in which all of the foreign genes (1)-(3) described below are transfected into a microbial cell in order to obtain collagen that can be a high-performance versatile material which is commercially more valuable as a pharmaceutical product, industrial product, cosmetic product, food and the like. (1) A foreign gene comprising a nucleotide sequence encoding the amino acid sequence of lysyl hydroxylase (2) A foreign gene comprising a nucleotide sequence encoding the amino acid sequence of prolyl hydroxylase (3) A foreign gene comprising a nucleotide sequence encoding the amino acid sequence of collagen. | 09-27-2012 |
20120253014 | PREVENTIVE AGENT FOR ATOPIC DERMATITIS - An object of the present invention is to provide a preventive agent for atopic dermatitis and food products containing the agent. The present inventors conducted extensive studies and, as the result, found that atopic dermatitis can be prevented by orally ingesting collagen. The present invention provides a preventive agent for atopic dermatitis comprising collagen and food products containing the preventive agent for atopic dermatitis. | 10-04-2012 |
20120277409 | METAL-POLYSACCHARIDE CONJUGATES: COMPOSITIONS, SYNTHESIS AND METHODS FOR CANCER THERAPY - The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one liner covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by said linker. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a linker to a polysaccharide to obtain an intermediate and by conjugating said intermediate to a metal to form a polysaccharide conjugate. This conjugate has a higher relaxivity, so it is suitable to be used as a contrast medium for hybrid camera. | 11-01-2012 |
20130023648 | Controlled Cross-Linking Processing of Proteins - A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20X) can be added to the solution until the volume ratio of PBS buffer (20X) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure. | 01-24-2013 |
20130030153 | CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE - Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation. | 01-31-2013 |
20130035473 | COLLAGEN MIXTURE AND METHOD OF MAKING THE SAME - A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen. | 02-07-2013 |
20130035474 | COLLAGEN MIXTURE AND METHOD OF MAKING THE SAME - A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen. | 02-07-2013 |
20130079495 | COLLAGEN FIBRILLAR CONSTRUCTION - Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering. | 03-28-2013 |
20130079496 | COLLAGEN MIXTURE AND METHOD OF MAKING THE SAME - A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen. | 03-28-2013 |
20130090455 | TRANSFORMANT WHICH PRODUCES GLYCINE REPEAT SEQUENCE PROTEIN - Disclosed is a transformant in which polynucleotides comprising a nucleotide sequence encoding the amino acid sequence of all of the following proteins (1) to (3) are transfected into a microbial cell:
| 04-11-2013 |
20130116411 | METHODS OF MAKING HYALURONIC ACID/COLLAGEN COMPOSITIONS - Hyaluronic acid and collagen may be crosslinked in aqueous solution as described herein. The crosslinked macromolecular matrices obtained in this process may be used as a hydrogel for implants and fillers for human aesthetic and therapeutic products. | 05-09-2013 |
20130116412 | Production of Post-Translationally Hydroxylated Recombinant Proteins in Bacteria - Bacterial cells capable of producing recombinant proteins, such as post-translationally hydroxylated recombinant proteins, methods and kits for producing recombinant proteins, such as post-translationally hydroxylated recombinant proteins, and particular post-translationally hydroxylated recombinant collagen molecules produced by the methods and cells disclosed herein are provided by this invention. | 05-09-2013 |
20130123468 | METHOD FOR EXTRACTING UNDENATURED TYPE II COLLAGEN HAVING ACTIVE EPITOPE - A method for extracting water-soluble undenatured type II collagen having an active epitope comprises a first step for extracting animal-derived cartilage using an acidic solution at 50° C. or less, and a second step for adding pepsin to the acidic solution and performing extraction at 40° C. or less. This allows the epitope of undenatured type II collagen to be extracted in large quantities and with high efficiency without any loss of activity, and makes it possible to provide a food or beverage product obtained using the water-soluble undenatured type II collagen extracted by the extraction method. | 05-16-2013 |
20130137854 | COLLAGEN MIXTURE AND METHOD OF MAKING THE SAME - A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen. | 05-30-2013 |
20130165634 | EXPRESSION AND EXPORT OF ANGIOGENESIS INHIBITORS AS IMMUNOFUSINS - A fusion protein of the invention comprises an immunoglobulin Fc region and a first target protein linked to the immunoglobulin Fc region. The first target protein comprises a collagen XVIII fragment, preferably endostatin. The immunoglobulin Fc region preferably comprises a hinge region, a C | 06-27-2013 |
20130172531 | HUMAN PLACENTAL COLLAGEN COMPOSITIONS, AND METHODS OF MAKING AND USING THE SAME - The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal. | 07-04-2013 |
20130190479 | COLLAGEN POWDER AND/OR COLLAGEN-DERIVED POWDER, AND PRODUCTION METHOD FOR THE SAME - Disclosed is a collagen powder and/or a collagen derivative powder, which are obtained by dispersing in a hydrophilic organic solvent a crude collagen precipitate which comprises 12 to 50% by mass of a collagen precipitate and/or a collagen derivative precipitate having an average particle size of 1 to 1,000 μm, recovering solids and then drying the solids. By dispersing the crude collagen precipitate in the hydrophilic organic solvent, the resulting precipitates can be dehydrated, so that drying of the thus obtained solids can be done by air-drying. In addition, the resulting collagen powder and/or collagen derivative powder exhibit excellent solubility due to an increased specific surface area and also have excellent ease of handling with the average particle size being 8 to 1,000 μm. | 07-25-2013 |
20130190480 | ORIENTED COLLAGEN/APATITE MATERIAL AND METHOD FOR PRODUCING ORIENTED COLLAGEN/APATITE MATERIAL - It is an object of the present invention to provide an oriented collagen/apatite material wherein an orientation is controlled, and a method of the oriented collagen/apatite material wherein an orientation is controlled. A method of producing an orientated collagen/apatite material according to the present invention, is characterized in that the method comprises; preparing a collagen having an orientation, seeding an osteoblast or a mesenchymal stem cell to produce and fix an apatite having an orientation similar to or almost the same as a direction of an orientation of the collagen on a surface and/or inside of the collagen. Furthermore, in a preferred embodiment of above mentioned method of producing an orientated collagen/apatite material according to the present invention, is characterized in that the osteoblast is an osteoblast like cell or an osteoblast obtained from a living organism. | 07-25-2013 |
20130225793 | COMPOSITIONS COMPRISING FIBROUS POLYPEPTIDES AND POLYSACCHARIDES - Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed. | 08-29-2013 |
20130289243 | COLLAGEN PRODUCING PLANTS AND METHODS OF GENERATING AND USING SAME - A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant. | 10-31-2013 |
20130296533 | Sebum Secretion-Blocking Composition, and Food or Beverage Containing Same - An object is to provide a sebum secretion inhibiting composition and a food or drink product using the same. The present inventors have conducted extensive studies and consequently found that the sebum secretion is inhibited by orally ingesting a collagen peptide, which is hydrolyzed collagen, and provide an oral sebum secretion inhibiting composition comprising a collagen hydrolysate and a food or drink product containing the composition. | 11-07-2013 |
20130310539 | Glycation Cross-link Breakers to Increase Resistance to Enzymatic Degradation - The present invention relates to a method to treat a grafts, implant, scaffold, and constructs, including allografts, xenografts, autografts, and prosthetics comprising collagen, with an inhibitor of collagen cross-links and/or advanced glycation endproducts (AGE), in order to alleviate the mechanical weakness induced by the cross-links The invention also provides for kits for use in the operating theater during autograft, allograft or xenograft procedures, or for preparing allograft, xenografts or prosthetics that have not been already treated prior to packaging. The kit comprises a first agent or agents that inhibit collagen cross-links and/or advanced glycation endproducts, instructions for use, optionally a wash or rinse agent, and a device for containing the graft and first agent. | 11-21-2013 |
20130310540 | EXTRACT OF AQUATIC ANIMAL CARTILAGE - An object of the present invention is to obtain a useful extract from aquatic animal tissues. The present invention provides a fish cartilage water extract containing a proteoglycan having a molecular weight of not less than 2,500,000 (250×10 | 11-21-2013 |
20140011980 | METHODS FOR STERILIZING COMPOSITIONS AND RESULTING COMPOSITIONS - Method for sterilizing a hydrogel composition include subjecting the composition to pulsed light comprising broadband spectrum radiation, the pulsed light being at a dose effective to sterilize the composition without causing significant change in rheology of the composition. | 01-09-2014 |
20140031526 | High Molecular Ordered Fibrilar Structures, Method for Their Preparation and Uses Thereof - The present invention relates to methods for generation of high molecular ordered fibrilar structures. More particularly, the method of the invention utilizes CBD's (cellulose binding domain) ability to form dimers for directing ordered assembly of fibrous proteins such as silk proteins into super-molecular fibrilar structures. The invention further provides fibrilar structures such as fibers and articles comprising said fibrilar structures. | 01-30-2014 |
20140128573 | METHOD FOR PRODUCING COLLAGEN-LIKE POLYPEPTIDE - An object is to provide a method for producing an ever-larger molecular weight collagen-like polypeptide single strand. Another object is to provide a method for controlling a molecular weight of a product to be obtained in desired magnitude upon producing a collagen-like polypeptide single strand. A solution is a method for producing a polypeptide including a step for allowing a condensation reaction of peptide oligomers represented by any one of formulas (1) to (3) (SEQ ID No:1 to SEQ ID No:3), wherein the condensation reaction is carried out in an aqueous solvent containing a phosphate ion in the range of 0 M to less than 0.01 M in the presence of a condensing agent, or a condensing agent and a condensing auxiliary: | 05-08-2014 |
20140163205 | DESIGNER COLLAGENS AND USE THEREOF - The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure. | 06-12-2014 |
20140213764 | NANOCELLULOSE FOAM CONTAINING ACTIVE INGREDIENTS - Nanocellulose foams containing at least one active ingredient and methods of preparing such nanocellulose foams containing one or more active ingredients are provided herein. In some embodiments, a method for preparing nanocellulose foam containing active ingredients may include forming a liquid mixture of nanocellulose, wherein the nanocellulose is at least one of dispersed, suspended or gelled in the liquid mixture; drying the liquid mixture of nanocellulose to form a nanocellulose foam; and mixing at least one active ingredient into at least one of the liquid mixture of nanocellulose or the nanocellulose foam. In some embodiments, a nanocellulose structure may include a nanocellulose foam comprising at least one of a carboxylate group, a hydroxyl group, or a sulfate group bonded to an active ingredient. In some embodiments, the nanocellulose structures are enhanced or crosslinked with metal cations. | 07-31-2014 |
20140221614 | COLLAGEN MATRIX WITH LOCALLY CONTROLLED INTRAFIBRILLAR AND EXTRAFIBRILLAR MINERAL CONTENT AND METHODS OF PRODUCING - A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration. | 08-07-2014 |
20140221615 | POROUS SCAFFOLD MATERIAL, AND METHOD FOR PRODUCING SAME - Provided are a scaffold material that functions as a scaffold material for two weeks or more in vivo and causes substantially no foreign-body reaction, and a method for producing the scaffold material. Specifically, a porous scaffold material comprising collagen fibers is provided. | 08-07-2014 |
20140288271 | METHOD FOR PRODUCING A COLLAGEN MEMBRANE AND USES THEREOF - The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen-containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen-containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue. | 09-25-2014 |
20140303347 | Collagen Powder - There is a need to provide a collagen powder having desirable product characteristics, such as high fluid absorption capacity, while also having processing characteristics that allow commercial manufacturing and handling of the collagen powder. The present invention relates to a collagen powder, a method of manufacture thereof, and uses thereof. In particular, the present invention relates to a process for preparing a collagen powder, the process comprising the steps of providing a collagen source; adjusting the concentration of the collagen source; adjusting the pH of the collagen source; freezing the collagen source; dehydrating the frozen collagen; and degrading the dehydrated collagen to a powder. | 10-09-2014 |
20140316109 | ACTIVATED COLLAGEN SCAFFOLD MATERIALS AND THEIR SPECIAL FUSED ACTIVE RESTORATION FACTORS - Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:12 at N-terminus | 10-23-2014 |
20140329993 | FOAM-FORMED COLLAGEN STRAND - Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents. | 11-06-2014 |
20150011733 | COLLAGEN 7 AND RELATED METHODS - Disclosed are methods of making collagen 7, or functional fragments thereof, as well as collagen 7, and functional fragments thereof produced by such methods, nucleic acids encoding collagen 7, and functional fragments thereof, as well as vectors and host cells comprising such nucleic acids. | 01-08-2015 |
20150094452 | COMPOSITIONS COMPRISING FIBROUS POLYPEPTIDES AND POLYSACCHARIDES - Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed. | 04-02-2015 |
20150141619 | CROSS-LINKED COLLAGEN COMPRISING METALLIC ANTICANCER AGENTS - The disclosure describes collagen constructs comprising anticancer agents, preferably, platinum, and related methods. | 05-21-2015 |
20150299295 | Collagen Fibrillar Construction - Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering. | 10-22-2015 |
20160046663 | Controlled Cross-Linking Processing of Proteins - A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The intermediate protein structure can be cross-linked by providing for a specific ratio of chemical cross-linking agents to form the cross-linked protein structure. The solution can be prepared by adding a cross-linker of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) at a ratio of two-to-one of NHS to EDC to alcohol. PBS buffer (20×) can be added to the solution until the volume ratio of PBS buffer (20×) to alcohol is about one-to-one. About 16 percent by weight of protein can be dissolved in the solution. The solution can be electrospun to form an intermediate protein structure. After a period of time, the protein structure can be cross-linked to form the cross-linked protein structure. | 02-18-2016 |
20160046692 | PURIFICATION OF TRIPLE HELICAL PROTEINS - The present invention relates to a method for purifying triple-helical or collagen-like proteins recombinantly produced from a bacterial, yeast or plant host cell. | 02-18-2016 |
20160089474 | Collagen Sponge - Provided is a collagen sponge which has compressive strength (stress) equivalent to that of a tissue into which the collagen sponge is to be implanted, has no unevenness in structure and stress, and has a pore structure for allowing cells to infiltrate thereinto. The collagen sponge is obtained by subjecting a collagen dispersion, a collagen solution, or a mixture thereof having a collagen concentration of 50 mg/ml or more to freeze-drying and insolubilization treatment thereafter. The collagen sponge thus obtained has a stress of from 10 kPa to 30 kPa when loaded with 10% strain, has in its surface and inside a pore structure having a mean pore diameter ranging from 50 μm to 400 μm, and has a pore diameter standard deviation equal to or less than 80% of the mean pore diameter. | 03-31-2016 |