Entries |
Document | Title | Date |
20090099159 | Method of Treating Diseases and Conditions Associated with an Altered Level of Amyloid Beta Peptides and New Enolcarboxamide Compounds - A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib | 04-16-2009 |
20100069374 | Tricyclic benzopyrane compound - This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof | 03-18-2010 |
20100234363 | HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 DATA-HYDROXYSTEROID DEHYDROGENASE - Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. | 09-16-2010 |
20110152253 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES - A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia. | 06-23-2011 |
20110319398 | INHIBITION OF YOPS TRANSLOCATION - The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of treating or preventing infections by administering compounds described herein to a subject in need thereof. | 12-29-2011 |
20130131051 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION - Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: | 05-23-2013 |
20140213581 | FUSED MULTI-CYCLIC SULFONE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 07-31-2014 |
20140315896 | BENZOPYRANOBENZOTHIAZINONES AND THEIR USE AS FUNGICIDES, ANTIBIOTICS AND ANTITUMOR AGENTS - This invention relates to the field of biologically active compounds and specifically to phaeofungins, of the general formula (I) or a pharmacologically acceptable salt, solvate, hydrate or a pharmacologically acceptable formulation thereof, pharmaceutical compositions comprising these compounds, methods for the production of the phaeofungins and their use as fungicide, antibiotic as well as antitumor agent. | 10-23-2014 |
20140336184 | METHOD TO ENHANCE COGNITION - The present invention concerns methods and compositions regarding suppression of double stranded RNA-activated protein kinase (PKR) to enhance cognition in an individual. In specific cases, an inhibitor of PKR is provided to the individual such that cognition is enhanced thereby, including by enhancing memory, for example. Kits are encompassed in certain embodiments. | 11-13-2014 |
20150296788 | PESTICIDALLY ACTIVE TRICYCLIC PYRIDYL DERIVATIVES - Compounds of formula (I), wherein the substituents are as defined in claim | 10-22-2015 |
20150307519 | SMALL MOLECULES FOR RESTORING FUNCTION TO P53 CANCER MUTANTS - Embodiments of the present provide methods of inducing p53 SRMMP-dependent cancer cell cytotoxicity. Such methods involve the steps of exposing a cancer cell that comprises a p53 SRMMP to an amount of a chemical compound sufficient to induce p53 SRMMP-dependent cancer cell cytotoxicity. In one embodiment, the present invention provides a method of treating cancer by determining the presence of a p53 mutation, and administering a therapeutically effective dosage of a composition comprising one or more promoting compounds. | 10-29-2015 |
20170233412 | INHIBITORS OF HIF PROLYL HYDROXYLASE | 08-17-2017 |