Class / Patent application number | Description | Number of patent applications / Date published |
514212020 | Spiro | 55 |
20080287420 | CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF - The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer. | 11-20-2008 |
20080287421 | 3,3-SPIROINDOLINONE DERIVATIVES - There are provided compounds of the general formulas | 11-20-2008 |
20080306044 | SPIROBENZOAZEPANES AS VASOPRESSIN ANTAGONISTS - The present invention is directed to a compound of Formula (I) or a form thereof: | 12-11-2008 |
20090042859 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES - The use of a compound of formula I, wherein Y is a single bond, C═O, C═S or S(O) | 02-12-2009 |
20090048230 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS - The present invention relates to the use of a 2-cyanopyrimidine compound of the formula | 02-19-2009 |
20090048231 | SUBSTITUTED PROLINAMIDES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS - The present invention provides new substituted prolinamides of the general formula (I) in which D, L, E, G, J, M, R | 02-19-2009 |
20090105219 | Spirolactam Tricyclic CGRP Receptor Antagonists - Compounds of formula I: | 04-23-2009 |
20090105220 | PROCESS FOR THE PREPARATION OF NONPEPTIDE SUBSTITUTED SPIROBENZOAZEPINE DERIVATIVES - Novel spirobenzoazepine compounds, novel processes for the preparation of nonpeptide substituted spirobenzoazepine derivatives, and novel processes for the preparation of intermediates in the preparation of such derivatives. Novel intermediates in the preparation of nonpeptide substituted spirobenzoazepine derivatives. | 04-23-2009 |
20090118258 | COMBINATION THERAPY COMPRISING ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND VASOPRESSIN RECEPTOR ANTAGONISTS - The present invention relates to certain pharmaceutical compositions containing at least one vasopressin receptor antagonist and at least one angiotensin converting enzyme (ACE) inhibitor and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of vasopressin and/or angiotensin converting enzyme mediated disorders. | 05-07-2009 |
20090124597 | SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS - Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent diseases or conditions associated with the activity of steroid hormone nuclear receptors. | 05-14-2009 |
20090137554 | 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY - Disclosed are chemical entities including compounds of Formula I | 05-28-2009 |
20090176757 | Bicyclic Spirohydantoin CGRP Receptor Antagonists - Compounds of formula I: | 07-09-2009 |
20090197867 | ENANTIOMERICALLY ENRICHED IMIDAZOAZEPINONE COMPOUNDS - The present invention provides an enantiomerically pure compound of Formula I: | 08-06-2009 |
20090253682 | HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS - Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions. | 10-08-2009 |
20090264410 | THERAPEUTIC COMPOUNDS AND USES THEREOF - Compounds of formula (I) are described herein | 10-22-2009 |
20090275560 | ORGANIC COMPOUNDS - The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by | 11-05-2009 |
20090325929 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF - Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R | 12-31-2009 |
20100029614 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE - Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions. | 02-04-2010 |
20100093701 | COMBINATION THERAPY COMPRISING ANGIOTENSIN RECEPTOR BLOCKERS AND VASOPRESSIN RECEPTOR ANTAGONISTS - The present invention relates to certain pharmaceutical compositions containing at least one vasopressin receptor antagonist and at least one angiotensin receptor blocker (ARB) and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of vasopressin and/or angiotensin-mediated disorders. | 04-15-2010 |
20100113418 | HETEROCYCLIC COMPOUND - The present invention provides a compound having an ACC inhibitory action, which is useful for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy. The present invention provides a compound represented by the formula (I): | 05-06-2010 |
20100113419 | CGRP RECEPTOR ANTAGONISTS - The present invention is directed to compounds of Formula I: | 05-06-2010 |
20100190772 | Substituted Azepine Derivatives As Serotonin Receptor Modulators - The present invention generally relates to compounds and pharmaceutical compositions containing the compounds. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity). | 07-29-2010 |
20100292212 | NEW AZACYCLIC DERIVATIVES - The present invention relates to compounds of formula (I) | 11-18-2010 |
20100305098 | METHODS OF USE - A method of treating a disorder such as rheumatoid arthritis or multiple sclerosis in a subject is carried out by administering to the subject a composition comprising a modulator compound of Th1 differentiation or Th17 expansion. | 12-02-2010 |
20100311720 | Spiroindoline Modulators of Muscarinic Receptors - The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 12-09-2010 |
20100324022 | NOVEL COMPOUNDS - Compounds of formula (I), pharmaceutical compositions thereof, and methods for treatment using the same. | 12-23-2010 |
20100324023 | IMIDAZOBENZAZEPINE CGRP RECEPTOR ANTAGONISTS - Compounds of Formula I: I (where variables R | 12-23-2010 |
20110009384 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA - The present invention provides an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. | 01-13-2011 |
20110021500 | NOVEL COMPOUNDS - The present invention relates to new CGRP-antagonists of general formula I | 01-27-2011 |
20110034437 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-10-2011 |
20110053911 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) - The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. | 03-03-2011 |
20110105470 | Novel Lapachone Compounds And Methods of Use Thereof - The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as β-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione). | 05-05-2011 |
20110124630 | STEMONAMIDE SYNTHESIS INTERMEDIATE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF CANCER - An objective of the invention is to provide a compound effective for prevention and/or treatment of cancer. The invention relates to a compound according to by formula I, or a salt, solvate or physiologically functional derivative thereof, and a composition for prevention and/or treatment of cancer comprising the same as an active ingredient: | 05-26-2011 |
20110178064 | SPIRO CONDENSED BARBITURIC ACID DERIVATIVES FOR USE AS ANTIBACTERIAL - In one aspect, the present invention relates to compounds of Formula (I): to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to method for their preparation. | 07-21-2011 |
20110218186 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE - Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions. | 09-08-2011 |
20110237569 | SPIRO AZEPANE-OXAZOLIDINONES AS Kv1.3 POTASSIUM CHANNEL BLOCKERS - This invention concerns Spiro azepane-ox-azolidinones as voltage gated Kv1.3 potassium channel blockers, pharmaceutical compositions containing these compounds, methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in the treatment of diabetes, psoriasis, obesity, transplant rejection and inflammatory neuropathies, including T-cell mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. The compounds have formula (1): | 09-29-2011 |
20110275613 | ORGANIC COMPOUNDS - The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by | 11-10-2011 |
20110294785 | INFLUENZA A VIRUS INHIBITION - Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein. | 12-01-2011 |
20110306595 | SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE - The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved. | 12-15-2011 |
20120015934 | CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF - The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer. | 01-19-2012 |
20120065190 | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS - Compounds of formula I: | 03-15-2012 |
20120077802 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF - Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein. | 03-29-2012 |
20120083484 | CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF - The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer. | 04-05-2012 |
20120283243 | Spiroindoline Modulators of Muscarinic Receptors - The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases. | 11-08-2012 |
20130012495 | 5HT2C RECEPTOR MODULATORS - The present invention relates to novel compounds of Formula (I): | 01-10-2013 |
20140005174 | INDOLE DERIVATIVES USEFUL AS CCR2 ANTAGONISTS | 01-02-2014 |
20140066432 | Substituted Benzoazepines As Toll-Like Receptor Modulators - Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease. | 03-06-2014 |
20140128375 | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS - Compounds of formula I: | 05-08-2014 |
20140179682 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF - Compounds that modulate GluR5 activity and methods of using the same are disclosed. | 06-26-2014 |
20140371206 | BROMODOMAIN INHIBITORS AND USES THEREOF - The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders. | 12-18-2014 |
20150018339 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS - Compounds having the general formula II, III, or IV | 01-15-2015 |
20150038490 | SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE - The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved. | 02-05-2015 |
20150099738 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 04-09-2015 |
20150148333 | BENZO [B] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF - The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders. | 05-28-2015 |
20160251359 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | 09-01-2016 |