Entries |
Document | Title | Date |
20090042815 | Macrolide Synthesis Process and Solid-State Forms - This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms. | 02-12-2009 |
20090075918 | VETERINARIAN COMPOSITION COMPRISING AN ORGANIC SALT OF LEVAMISOLE IN COMBINATION WITH AT LEAST ONE AVERMECTINE AND/OR MILBEMYCINE - Veterinarian composition comprising an organic salt of levamisole in combination with at least one avermectine and/or milbemycine. A veterinarian formulation comprising of organics salts of levamisole, more specifically to the disophenolat salt of levamisole and the nitroxynil-salt of levamisole with avermectines and milbemycines and its use in treatment of helminthiasis in mammals, in particular in bovines, swines, caprines, equines, ovines, canines and felines. | 03-19-2009 |
20090093421 | ADMINISTRATION OF AVERMECTIN/MILBEMYCIN COMPOUNDS FOR THE TREATMENT OF OPHTHALMIC PATHOLOGIES - Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea. | 04-09-2009 |
20090318375 | Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same - This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same. | 12-24-2009 |
20100016248 | TABLET FORMULATION - The invention relates to a tablet formulated for administration to an animal to treat parasite infestation. The tablet includes at least one macrocyclic lactone compound with anthelmintic activity dissolved in at least one organic solvent and subsequently formulated into a tablet. The tablets produced have a high degree of stability when stored over time and also provide the animal with a dose of agent sufficient to be therapeutically effective. | 01-21-2010 |
20100130437 | TOPICAL ANTIBIOTIC COMPOSITION FOR THE PREVENTION OF LYME DISEASE - A topical pharmaceutical composition comprising an antibiotic is useful for the prevention of Lyme disease. | 05-27-2010 |
20100168043 | METHOD FOR THE PROTECTION OF TREES - The present invention provides a method for the prevention/treatment of hark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone. | 07-01-2010 |
20100197624 | ANTHELMINTIC COMBINATION - A method is provided for the treatment of parasitic infestations in mammals, comprising the step of simultaneously or sequentially administering to the mammal effective amounts of (a) 2-desoxoparaherquamide; and (b) abamectin. Also provided is an anthelmintic composition comprising 2-desoxoparaherquamide and abamectin. | 08-05-2010 |
20100210574 | AVERMECTIN B1 AND AVERMECTIN B1 MONOSACCHARIDE DERIVATIVES HAVING AN ALKOXYMETHYL SUBSTITUENT IN THE 4"-OR 4'-POSITION - What is described are a compound of the formula | 08-19-2010 |
20100234312 | AVERMECTIN DERIVATIVES - Novel avermectin derivatives of the formula (I) | 09-16-2010 |
20100249050 | EPOTHILONE GLYCOSIDE AND USE THEREOF - An epothilone glycoside having a formula of | 09-30-2010 |
20110003763 | AVERMECTIN/BENZOYL PEROXIDE COMPOSITIONS FOR TREATING AFFLICTIONS OF THE SKIN, E.G., ROSACEA - Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and benzoyl peroxide, are useful for treating afflictions of the skin, especially rosacea. | 01-06-2011 |
20110009350 | Oil-in-Water Formulation of Avermectins - Oil-in-water emulsion formulations (EW) of avermectins based on esters of fatty acids as solvent and the use of such formulations for the control of crop pests. | 01-13-2011 |
20110144045 | USE OF FUMAGILLIN AND THE DERIVATIVES THEREOF TO INCREASE THE BIOAVAILABILITY OF THE MACROCYCLIC LACTONES - A method for increasing the bioavailability of antiparasitic active ingredients, and therefore to potentiate the effects thereof, including combining antiparasitic active ingredients with an adjuvant, wherein, the antiparasitic active ingredients are capable of being recognized and binding to cellular transporters in order to be transported out of cells without being able to reach an intracellular therapeutic target, the transporters being present in the cells of the human or animal organism to which the antiparasitic active ingredients are administered, and, optionally, in the cells of parasites against which the antiparasitic active ingredients are administered, the adjuvant is a compound corresponding to fumagillin of the following formula (II): | 06-16-2011 |
20110144046 | ANTHELMINTIC COMPOSITIONS - An anthelmintic composition comprising two or more active agents, each agent being selected from a separate anthelmintically active family, the families being a macrocyclic lactone (ML), levamisole or its equivalent and a benzimidazole, in a suitable carrier, which includes at least one effective protective agent, which stabilises the chemical and physical activity of the ML, such as hydroxypropyl starch phosphate. | 06-16-2011 |
20110190231 | THIOAMIDE COMPOUNDS, METHOD OF MAKING AND METHOD OF USING THEREOF - The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): | 08-04-2011 |
20110201567 | Ivermectin Antagonizes Ethanol Inhibition in P2X4 Receptors - A method for reducing alcohol consumption in a subject includes a step of identifying a subject exhibiting at least one symptom of alcoholism and then administering a therapeutically effective amount of an Ivermectin analogue-containing composition to the subject. A method of screening Ivermectin analogues for reducing alcohol consumption is also provided. | 08-18-2011 |
20110230429 | AVERMECTIN B1 AND AVERMECTIN B1 MONOSACCHARIDE DERIVATIVES HAVING AN ALKOXYMETHYL SUBSTITUENT IN THE 4"-OR 4'-POSITION - What is described are a compound of the formula | 09-22-2011 |
20110245191 | PARASITICIDAL COMPOSITIONS COMPRISING MULTIPLE ACTIVE AGENTS, METHODS AND USES THEREOF - This invention relates to compositions for combating ectoparasites and endoparasites in animals, comprising at least one 1-arylpyrazole, at least one macrocyclic lactone, at least one insect growth regulator, and at least one anthelmintic compound in combination with a pharmaceutically acceptable carrier. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. | 10-06-2011 |
20110263520 | COMPOSITION FOR USE IN CONTROLLING HARMFUL ORGANISMS THAT CONTAINS 16-KETO ASPERGILLIMIDE - Disclosed is a composition for use in controlling harmful organisms, comprising as active ingredients at least one of 16-keto aspergillimide, its enantiomers, their mixture, or their acid addition salts and at least one of other harmful organism control agents. The present invention provides a composition for use in controlling harmful organisms that has excellent insecticidal activity or penetrative transferable insecticidal activity against a wide range of harmful organisms, particularly agricultural and horticultural insect pests. | 10-27-2011 |
20110275583 | Synergistic active compound combinations - Novel active compound combinations comprising compounds of the formula (I) and compounds of the formula (II) have very good insecticidal and acaricidal properties. | 11-10-2011 |
20110294751 | HIGH DOSAGE DORAMECTIN FORMULATION - Veterinary compositions which provide a high-dose of doramectin or a high-dose veterinary combination composition which comprises doramectin and one or more other antiparasitic agents is disclosed. The compositions provide both antiparasitic efficacy and a significantly reduced withhold time. | 12-01-2011 |
20120010161 | NOVEL AZAPEPTIDE OR AZAPEPTIDOMIMETIC COMPOUNDS INHIBITING BCRP AND/OR P-GP - The present invention relates to compounds of azapeptide or azapeptidomimetic type of formula (I): | 01-12-2012 |
20120015895 | Use Of RR/SR-Ractopamine - A method of promoting or improving the feed efficiency and the muscle-to-fat ratio in animals by administering to the animals a therapeutically effective amount of a mixture of RR-ractopamine and SR-ractopamine is disclosed. Manufacturing methods for making RR/SR-ractopamine are presented. | 01-19-2012 |
20120015896 | Anti-Penicillin Resistant Pneumococci Agent and Novel 16-Membered Macrolide Derivative - A novel compound that has antimicrobial activity against penicillin-resistant | 01-19-2012 |
20120035122 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS - This invention recites isoxazoline substituted azetidine derivatives of Formula (1) | 02-09-2012 |
20120035123 | COMBINATION OF COMPOUNDS FOR TREATING OR PREVENTING SKIN DISEASES - A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described. | 02-09-2012 |
20120058964 | PHARMACEUTICAL FORMULATION - Disclosed are novel formulations for the treatment of otic infections in an animal comprising a triazole anti-fungal compound, a quinolone antibiotic and a corticosteroid such as mometasone furoate monohydrate. | 03-08-2012 |
20120077764 | COMPOSITIONS AND METHOD FOR TREATING INFECTION IN CATTLE AND SWINE - Novel formulations containing a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol, and methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease. | 03-29-2012 |
20120077765 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS - This invention recites naphthyl isoxazoline oxime derivatives of Formula (1) | 03-29-2012 |
20120077766 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS - Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin. | 03-29-2012 |
20120083463 | Insecticidal and Fungicidal Active Compound Combinations - The present invention relates to active compound combinations consisting, firstly, of a known halogen-substituted derivative (component A) and, secondly, of further known pesticidally active compounds (component B), which active compound combinations are suitable for controlling animal and microbial pests. | 04-05-2012 |
20120122808 | MACROLIDE SYNTHESIS PROCESS AND SOLID-STATE FORMS - Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, among other uses, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms. | 05-17-2012 |
20120196821 | METHOD AND FORMULATION FOR THE CONTROL OF PARASITES - An aqueous micellar formulation for localised topical application to an animal for the concurrent control of internal and external parasites in and on the animal, the formulation comprising a water-miscible co-solvent, a fatty alcohol alkoxylate, a macrocyclic lactone and water. Also described is a method for the concurrent control of internal and external parasites in and on an animal, the method comprising administering to the animal by localised topical application an aqueous micellar formulation comprising a macrocyclic lactone. | 08-02-2012 |
20120208779 | MACROLIDE SYNTHESIS PROCESS AND SOLID-STATE FORMS - Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms. | 08-16-2012 |
20120232026 | SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS - The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) | 09-13-2012 |
20120238516 | GRANULATED ANTHELMINTIC PREPARATIONS AND DELIVERY SYSTEMS - The present invention relates to anthelmintic compositions comprising two or more anthelmintic active agents selected from one or more of the following groups; imidazothiazoles such as levamisole, benzimidazoles such as oxfendazole, or fenbendazole, macrocylic lactones such as ivermectin or avermectin, salicylanilides, and praziquantel. The composition being in the form of stable granules that are readily dispersible in water so as to provide a homogenous mixture of the anthelmintic agents suitable for administration. Methods of preparing the composition are also described. | 09-20-2012 |
20120238517 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES - The present invention relates to compounds of formula (I): Wherein A | 09-20-2012 |
20120245114 | METHOD FOR THE PROTECTION OF TREES - The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone. | 09-27-2012 |
20120277175 | PHARMACEUTICAL COMBINATIONS, PHARMACEUTICAL COMPOSITIONS, MEDICAMENT AND METHOD FOR THE TREATMENT OF ANIMALS - This invention relates to antihelminthic pharmaceutical combinations comprising iodinated aromatic compounds, such as disophenol or nitroxynil, with other pharmaceutical active ingredients targeting the treatment of animals. More specifically, this invention concerns pharmaceutical compositions comprising disophenol or nitroxynil with at least one other pharmaceutical antihelminthic active ingredient, selected from among benzimidazoles, thiabendazole, levamisole or tetramisole salts, avermectins or milbemycins and, even more preferably, levamisole salts selected from between levamisole chloride or phosphate. | 11-01-2012 |
20120316124 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES - The present invention relates to compounds formula (I), wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; and wherein A | 12-13-2012 |
20130023490 | TOPICAL FORMULATIONS COMPRISING 1-N-ARYLPYRAZOLE DERIVATIVES AND AMITRAZ - The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs. | 01-24-2013 |
20130035303 | COMPOSITIONS AND METHODS FOR CONTROL OF SAND FLIES AND OTHER BLOOD SUCKING INSECTS - The invention relates to a new rapid release oral formulation of fipronil or imidacloprid for the effective control of blood-sucking insect populations. Embodiments of the invention relate to their use by incorporation into a feed-through formulation that can be administered orally to host animals such as birds, goats, dogs, and cattle for the rapid effective control of blood sucking insects. The formulation is fast acting and the residue of the chemicals present in the feces serves as a larvacide, effectively controlling newly hatched larvae. | 02-07-2013 |
20130053336 | TREATMENT OF CHLAMYDIACEAE INFECTIONS BY MEANS OF BETA-LACTAMS - The invention relates to a method for treating infections of bacteria of the | 02-28-2013 |
20130065846 | PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF - This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. | 03-14-2013 |
20130065847 | ENDOPARASITICIDAL COMPOSITIONS - The invention relates to a synergistic composition for controlling endoparasites in and on animals, which comprises a combination of
| 03-14-2013 |
20130065848 | LEVOISOVALERYLSPIRAMYCIN I, II OR III, PREPARATIONS, PREPARTATION METHODS AND USES THEREOF - Disclosed are levoisovalerylspiramycin I, II or III, preparations, preparing methods and uses thereof. The preparations comprise levoisovalerylspiramycin I, II or III and pharmaceutically acceptable carrier and/or adjuvant, wherein the purity of levoisovalerylspiramycin I, II or III is above 90 wt %. The levoisovalerylspiramycin I, II or III has a good antibacterial activity, and the preparations include solution for injection, powder for injection or lyophilized powder for injection. | 03-14-2013 |
20130090295 | METHODS OF ACCELERATING MUSCLE GROWTH, DECREASING FAT DEPOSITS AND IMPROVING FEED EFFICIENCY IN LIVESTOCK ANIMALS - A method of promoting or improving the feed efficiency and the muscle to fat ratio in animals by administering to the animals a therapeutically effective amount of a pure or substantially pure RR-isomer of ractopamine is disclosed. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or decreasing body fat, or promoting or improving the growth of an animal or improving the feed efficiency of an animal. Feed preparation, compositions and pharmaceutical preparations including therapeutically effective amounts of a pure or substantially pure RR-isomer of ractopamine are disclosed. | 04-11-2013 |
20130090296 | INJECTABLE FORMULATION OF A MACROCYCLIC LACTONE AND LEVAMISOLE - The present invention relates to formulations for controlling parasites, comprising a combination of macrocyclic lactone compound and levamisole wherein the levamisole is in particulate form suspended in a non-aqueous solvent | 04-11-2013 |
20130096077 | Nematicidal Mixtures for Use in Sugar Cane - A method for the synergistic plant nematode control in sugar cane with a mixture of fipronil and abamectin comprising fipronil and abamectin in a ratio by weight of from 1:10 to 10:1, wherein the mixture is applied to sugar cane in furrow, a method for the synergistic plant nematode control in sugar cane with a mixture of fipronil and abamectin comprising fipronil and abamectin in a ratio by weight of from 1:10 to 10:1, wherein the mixture is applied to plant propagation materials of sugar cane, and a method which combines synergistic plant nematode control with (preferably synergistic) improvement of the plant health of sugar cane plants. | 04-18-2013 |
20130102552 | PESTICIDAL COMPOSITION AND ITS USE - A composition comprising a carboxamide compound represented by following formula (I), wherein R | 04-25-2013 |
20130109642 | ADMINISTRATION OF AVERMECTIN/MILBEMYCIN COMPOUNDS FOR THE TREATMENT OF OPHTHALMIC PATHOLOGIES | 05-02-2013 |
20130143829 | Topical Combination Formulations of Macrocyclic Lactones with Synthetic Pyrethroids - The present invention provides pyrethroid/macrocyclic lactone-containing topical formulations that are effective against animal pests, including ecto- and endoparasites. The formulations may be used for combating parasites in or on birds and mammals. The invention also provides for an improved method for eradicating, controlling and preventing parasite and/or pest infestation of birds and mammals. | 06-06-2013 |
20130150316 | LEVOCARRIMYCIN, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF - The present invention relates to levocarrimycin, its pharmaceutical compositions, preparation methods and application. Levocarrimycin is a mixture of isovalerylspiramycin III, II and I as main components and contains some isobutyrylspiramycin III and II, butyrylspiramycin III and II, propionylspiramycin III and II, as well as acetylspiramycin III and II, among which, the content of isovalerylspiramycin III is no less than 30 wt %, the total content of isovalerylspiramycin III, II and I is no less than 60 wt %, and the content of acylspiramycin is 80-98 wt %. Specific optical rotation of said levocarrimycin is [α] | 06-13-2013 |
20130172281 | COMPOSITIONS FOR TREATING HEARTWORM INFESTATION - The present invention further relates to ivermectin, most preferably formulated as an implant for administration of pet and domestic animals. These formulations provide long term protection against | 07-04-2013 |
20130172282 | METHOD OF TREATING HERPES VIRUS INFECTION USING MACROCYCLIC LACTONE COMPOUND - A method of treating herpes simplex virus infection or varicella zoster virus infection is disclosed. The method includes topically applying a composition containing an effective amount of one or more macrocyclic lactone compounds, including avermectin compounds or milbemycin compounds and a pharmaceutically acceptable carrier to the affected area of an individual suffering from herpes simplex virus infection or varicella zoster virus infection. | 07-04-2013 |
20130178432 | COMPOSITIONS FOR CONTROLLING HEARTWORM INFESTATION - The present invention relates to ivermectin formulations for administration to pet and domestic animals. These formulations provide long term protection against Dirofilaria parasites, without the risks for secondary adverse of conventional formulations. Preferred formulations are collars, collar strips, or medallions, attachments for collars, ear tags, bands which are affixed to limbs or parts of the body, adhesive strips and films, and peel-off films, or spot-on or pour-on forms which are administered at least twice a year up to around once a year. | 07-11-2013 |
20130178433 | METHOD OF TREATING HEMORRHOIDS USING MACROCYCLIC LACTONE COMPOUND - A method of treating hemorrhoids is disclosed. The method includes locally administering a composition including an effective amount of one or more macrocyclic lactone compounds, including avermectin compounds, milbemycin compounds, or mixture thereof and a pharmaceutically acceptable carrier to the affected anorectal region of an individual suffering from hemorrhoid. | 07-11-2013 |
20130178434 | METHOD OF TREATING OTITIS EXTERNA USING MACROCYCLIC LACTONE COMPOUND - A method of treating otitis externa is disclosed. The method includes topically applying an otic composition containing an effective amount of one or more macrocyclic lactone compounds, including avermectin compounds or milbemycin compounds and a pharmaceutically acceptable carrier into the external auditory canal and the auricle of an affected ear of an individual suffering from otitis externa. | 07-11-2013 |
20130190260 | ACTIVE AGENT COMBINATIONS - The novel active compound combinations of
| 07-25-2013 |
20130203692 | PARASITICIDAL ORAL VETERINARY COMPOSITIONS COMPRISING SYSTEMICALLY-ACTING ACTIVE AGENTS, METHODS AND USES THEREOF - This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. | 08-08-2013 |
20130231299 | METHODS FOR REDUCING NEMATODE DAMAGE - A method of reducing damage to plant propagation material and plant organs which grow at a later time by a representative of the class Nematoda, which method comprises (i) treating the propagation material with (A) a chelating agent, and optionally (B) a macrocyclic lactone compound or another pesticide, before the material is sown or planted, or (ii) applying (A) a chelating agent, and optionally (B) a macrocyclic lactone compound or another pesticide, to the locus of the material or the treated material defined in (i) before its planting, and/or at its planting and/or during its growth. | 09-05-2013 |
20130261069 | PESTICIDAL MIXTURES COMPRISING ISOXAZOLINE DERIVATIVES - The present invention provides pesticidal mixtures comprising a component A, a component B and a component C, wherein component A is a compound of formula (I) wherein one of Y | 10-03-2013 |
20130267476 | Pesticidal Active Mixtures Comprising Pyrazole Compounds - The present invention relates to pesticidal mixtures comprising as active compounds
| 10-10-2013 |
20130274215 | PHARMACEUTICAL COMPOSITIONS TO TREAT FIBROSIS - The present invention provides methods for the prevention, treatment and/or amelioration of fibrosis or fibrotic conditions. The present invention further provides small molecule inhibitors of Wnt- and TGF-p-mediated β-catenin signaling to prevent, treat and/or ameliorate fibrosis or fibrotic conditions. Kits comprising small molecule inhibitors of Wnt- and TGF-p-mediated β-catenin signaling and methods of identifying small molecule inhibitors of Wnt- and TGF-p-mediated β-catenin signaling are also provided. | 10-17-2013 |
20130281391 | PEST CONTROLLING COMPOSITION AND METHOD FOR CONTROLLING PEST - The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more macrolide compound(s) selected from Group (A) shows an excellent controlling activity on a pest. Group (A): a group consisting of abamectin, doramectin, emamectin, emamectin-benzoate, lepimectin, milbemectin, spinetoram and spinosad | 10-24-2013 |
20130281392 | PARASITICIDAL COMPOSITIONS COMPRISING BENZIMIDAZOLE DERIVATIVES, METHODS AND USES THEREOF - The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof. | 10-24-2013 |
20130288990 | CONTROLLING PESTS BY COMBINING INSECTICIDES AND TRANSGENIC PLANTS BY APPLYING DIRECTLY TO LEAVES AND ROOTS - The invention relates to a method for controlling pests using a combination of insecticides and transgenic plants and consequently improving the utilization of the production potential of transgenic plants which comprises treating the plant with active compound combinations comprising an active compound from the group of the anthranilamides and at least one further insecticide. | 10-31-2013 |
20130331348 | Process for Manufacturing Chewable Dosage Forms for Drug Delivery and Products Thereof - A palatable, edible soft chewable medication vehicle for delivery of a pharmaceutically acceptable active ingredient, such as a drug, to an animal or human subject. The edible soft chews contain only food grade or better inactive ingredients, and preferably do not contain ingredients of animal origin. Processes for manufacturing the edible soft chews do not require the use of heat or the addition of water during mixing of active and inactive ingredients, provide stable concentrations of the active ingredient, and produce chews of consistent weight and texture. | 12-12-2013 |
20140051653 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS - Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin. | 02-20-2014 |
20140080779 | MACROCYCLIC LACTONES AND USE THEREOF - The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling in particular the treatment of colorectal cancer. | 03-20-2014 |
20140100181 | TOPICAL PHARMACEUTICAL COMPOSITION CONTAINING A WATER-SENSITIVE ACTIVE PRINCIPLE - A topical pharmaceutical composition including, as a pharmaceutical active agent, a water-sensitive compound in a solubilised form in a physiologically acceptable medium is described. A method for preparing such a composition, and uses thereof in dermatology are also described. | 04-10-2014 |
20140107055 | METHOD FOR THE PROTECTION OF TREES - The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone. | 04-17-2014 |
20140107056 | INSECTICIDAL COMPOUNDS - The present invention provides compounds of formula (I): wherein A | 04-17-2014 |
20140107057 | PESTICIDAL MIXTURES INCLUDING ISOXAZOLINE DERIVATIVES - The present invention provides a combination product comprising a component A and a component B, wherein component A is a compound of formula (I) wherein A | 04-17-2014 |
20140171380 | Screening Assays Using Stem Cells and Stem Cell-Derived Neurons from Mouse Models of Alzheimer's Disease - Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid β-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens. | 06-19-2014 |
20140171381 | PESTICIDAL COMPOSITIONS - A method of controlling or preventing pathogenic damage or pest damage in a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time, which comprises applying on the plant, part of the plant, or surroundings thereof, a pesticidal combination comprising, for example, at least three active ingredient components optionally together with one or more customary formulation auxiliaries, wherein component (I) is one or more of an—azole fungicide, component (II) is one or more of a phenylamide fungicide, component (III) is one or more of a strobilurin fungicide and/or one or more of a phenylpyrrole fungicide, in any desired sequence or simultaneously. | 06-19-2014 |
20140221299 | ANTI-PARASITIC COMPOSITION COMPRISING A MACROCYCLIC LACTONE AND LEVAMISOLE AND METHOD OF TREATMENT OF PARASITIC INFESTATION - This invention relates to a veterinary antiparasitic solubilised composition including a macrocyclic lactone or a pharmaceutically equivalent salt thereof, and levamisole or a pharmaceutically equivalent salt thereof, characterised in that the pH of the composition is in the range of 2.0 to 5.0 and wherein the composition includes at least one surfactant and at least one antioxidant. | 08-07-2014 |
20140221300 | USE OF MACROLIDES IN PEST CONTROL - In an embodiment the present invention is drawn to a a method of controlling wood pests and molluscs with a macrolide compound, wherein a pesticidally active amount of a pesticide comprising, as pesticidally active compound, at least one macrolide, in free form or agrochemically utilizable salt form, as active ingredient and at least one auxiliary is applied to the pests or their environment. | 08-07-2014 |
20140249096 | COMBINATION OF COMPOUNDS FOR TREATING OR PREVENTING SKIN DISEASES - A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay, is described. | 09-04-2014 |
20140256662 | ADMINISTRATION OF AVERMECTIN/MILBEMYCIN COMPOUNDS FOR THE TREATMENT OF OPHTHALMIC PATHOLOGIES - Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea. | 09-11-2014 |
20140315842 | Avermectins and Milbemycins as Anti-Mycobacterial Agents - The present invention relates to methods of treating a mycobacterial infection. In particular, this invention relates to methods, uses and compounds for use in treating mycobacterial infections, including | 10-23-2014 |
20140336139 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS - Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin. | 11-13-2014 |
20140343004 | Compositions for Oral Administration to Animals, Processes for Obtaining the Same and the Uses Thereof - The present invention concerns a solid, palatable composition and its preparation process which, relative to the total weight of the composition, comprises:
| 11-20-2014 |
20140349954 | ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION - The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (I); a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal. | 11-27-2014 |
20140357587 | Use of Glutaryl Histamine for the Treatment of Respiratory Tract Diseases - The invention relates to a medicament for the treatment of respiratory tract diseases selected from the group including rhinosinusitis, sinusitis, tonsillitis, bronchiolitis, pneumonia, and acute respiratory distress syndrome, wherein the medicament comprises glutaryl histamine or a pharmaceutically acceptable salt thereof in an effective amount. The invention also relates to use of glutaryl histamine or a pharmaceutically acceptable salt thereof for manufacture a medicament for the treatment of a respiratory tract disease. The medicament provides potentiating the effectiveness of antibacterial therapy for the treatment of respiratory tract diseases. | 12-04-2014 |
20140364384 | MEDICATION ADHERENCE MONITORING SYSTEM - The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable. | 12-11-2014 |
20140371164 | Synergistic Combination Comprising Avermectins and a NSAID for Tumor Inhibition - The present invention includes a composition comprising an effective amount of an avermectin compound, and an effective amount of an imidazole antifungal compound, and/or an effective amount of non-steroidal anti-inflammatory drug (NSAID) or suitable pharmaceutically acceptable salts thereof, for use in the inhibition of tumor growth and treating urothelial, colorectal, prostate and/or breast cancers. Furthermore, the invention includes a method of inhibiting tumor growth and treating said cancers comprising administering to a subject in need thereof an effective amount of said composition. | 12-18-2014 |
20150011489 | TREATMENT OF INFLAMMATORY LESIONS OF ROSACEA WITH IVERMECTIN - Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts. | 01-08-2015 |
20150011490 | TREATMENT OF PAPULOPUSTULAR ROSACEA WITH IVERMECTIN - Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments. | 01-08-2015 |
20150011491 | TREATMENT OF PAPULOPUSTULAR ROSACEA WITH IVERMECTIN - Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments. | 01-08-2015 |
20150018293 | ANIMAL TREATMENTS - Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said composition dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal. | 01-15-2015 |
20150038440 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS - This invention recites dihydrofuran substituted azetidine derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in mammals and birds. The substituents A, R | 02-05-2015 |
20150045314 | PESTICIDAL COMPOSITION - Non-aqueous pesticidal macrolide compositions are provided which comprise (A) a major amount of at least one non-aqueous solvent selected from a glycol ether and a lactimide; (B) a minor amount of a mixture of (i) at least one pesticide selected from abamectin and emamectin benzoate, and (ii) optionally, at least one surfactant. In one embodiment, the at least one pesticide selected from abamectin and emamectin benzoate is present in the composition in an amount of at least 7% by weight. In another embodiment, the compositions of the invention are chemically stable. The compositions of the invention can be used directly as a concentrate for treating or reducing tree pest infestations by trunk injection or with dilution in water for control of pests in crops of useful plants. | 02-12-2015 |
20150045315 | METHOD OF TREATING HYPERESTHESIA, PARESTHESIA, DOLOR, AND PRURITUS CAUSED BY INSECT STINGS OR NOXIOUS WEEDS OR PLANTS USING AVERMECTIN COMPOUND - A method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by an insect or arthropod sting or bite, or a skin contact with a noxious weed or plant is disclosed. The method includes topically applying a dermatological composition containing an avermectin compound to an affected area immediately after said sting or bite, or said skin contact occurs. The method further includes moistening the affected area first prior to application of the dermatological composition. | 02-12-2015 |
20150057239 | SOLID ORAL PHARMACEUTICAL COMPOSITIONS FOR ISOXAZOLINE COMPOUNDS - A solid oral pharmaceutical composition for delivery of a pharmaceutically acceptable active ingredient to an animal where the composition comprises an isoxazoline compound, a solvent and an excipient, a process for the manufacture of such solid oral pharmaceutical composition and a method of controlling a parasite infection administering such solid oral pharmaceutical composition. | 02-26-2015 |
20150105340 | TOPICAL AVERMECTIN FORMULATIONS AND METHODS FOR ELIMINATION AND PROPHYLAXIS OF SUSCEPTIBLE AND TREATMENT RESISTANT STRAINS OF HEAD LICE - An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice ( | 04-16-2015 |
20150306027 | TOPICAL APPLICATION OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS/AFFLICTIONS - Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin. | 10-29-2015 |
20150306123 | USE OF IVERMECTIN AND DERIVATIVES THEREOF - The present invention relates to the new use of antiparasitic agents, such as ivermectin, abamectin/avermectin, doramectin and so on, and the design method of the derivatives for the new use. The said compounds including macrolide abamectin/avermectin, ivermectin, doramectin and the derivatives thereof, may be used in the manufacture of a medicament for use in treating metabolic related diseases in a mammal, such as hyperglycemia, insulin resistance, hypertriglyceridemia, hypercholesterolemia, diabetes, obesity, etc, and Famesoid X receptor mediated diseases, such as cholestasia, gallstone, non alcohol fatty liver disease, atherosclerosis, inflammation, cancer, etc. | 10-29-2015 |
20150366198 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF - The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof. | 12-24-2015 |
20150366205 | AGROCHEMICAL FORMULATION, METHOD MAKING, AND METHOD OF USING - Agrochemical formulations for treating plants, which formulations comprise, as cosolvent, polyethylene glycol (average molecular weights ranging from 200 to 400) or polypropylene glycol (average molecular weights ranging from 300 to 400) or mixtures, and, if appropriate, further additives, a process for preparing these formulations, their use for treating plants and/or their habitat and for increasing the efficacy and plant compatibility of these formulations, and for reducing volatile emission potential of these formulations. | 12-24-2015 |
20150376222 | MACROLIDES USEFUL AS ANTICANCER AGENTS - The present invention relates to a compound of the following formula (I) or to a salt, hydrate, or pharmaceutically acceptable solvate thereof, in which R is a monosaccharide or disaccharide residue. The hydroxyl functions of the monosaccharide or disaccharide residue are, independently, optionally substituted for a (C | 12-31-2015 |
20160008471 | TRANSDERMAL FORMULATIONS | 01-14-2016 |
20160016927 | DIHYDROBENZOFURAN DERIVATIVES AS INSECTICIDAL COMPOUNDS - Provided are compounds of formula (I) and methods of controlling insects, acarines, nematodes or molluscs, which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I). | 01-21-2016 |
20160051508 | USE OF A MACROCYCLIC LACTONE FOR TREATING A COMPLICATION FROM A PAPILLOMA VIRUS INFECTION - A compound is described that is selected from among macrocyclic lactones for treating and/or preventing a complication from a human papillomavirus infection. The complication to be treated and/or prevented can be selected from among malignant melanomas, skin carcinomas, in situ or invasive carcinomas, epidermoid carcinomas, Bowen's disease, head and neck cancers, upper aerodigestive tract cancers, laryngeal cancers, esophageal cancers, stomach cancers, oral papillomas, pharyngeal papillomas, laryngeal papillomas, esophageal papillomas, lung cancers, intravulval neoplasias, intravaginal neoplasias, intracervical neoplasias, cervical dysplasias, cervical carcinomas, penile cancer, intrapenile neoplasias, and in situ or invasive anal carcinomas. | 02-25-2016 |
20160051524 | STABLE VETERINARY COMBINATION FORMULATIONS OF MACROCYCLIC LACTONES AND IMIDAZOTHIAZOLES - The present invention is directed to stabilized compositions comprising at least one macrocyclic lactone, or derivative thereof, in combination with levamisole, and an amino sugar stabilizing agent, optionally an additional antiparasitic agent, and a method for treating or controlling a parasitic infection or infestation in an animal by administering said composition. | 02-25-2016 |
20160057996 | PESTICIDE FORMULATION COMPRISING A WATER SOLUBLE ACTIVE INGREDIENT AND A PENETRATION ENHANCER AND USE OF THE SAME - The present disclosure relates to an improved formulation comprising at least one water soluble active ingredient and at least one penetration enhancer. The present disclosure also relates to a use of an improved formulation comprising at least one water soluble active ingredient and at least one penetration enhancer for preventing, combating or controlling pests, particularly insect infestations, by tree injection. | 03-03-2016 |
20160095825 | ANIMAL TREATMENTS - Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said composition dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal. | 04-07-2016 |
20160143935 | TREATMENT OF INFLAMMATORY LESIONS OF ROSACEA WITH IVERMECTIN - Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts. | 05-26-2016 |
20160158263 | TREATMENT OF PAPULOPUSTULAR ROSACEA WITH IVERMECTIN - Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments. | 06-09-2016 |
20160175337 | TREATMENT OF PAPULOPUSTULAR ROSACEA WITH IVERMECTIN | 06-23-2016 |
20160184342 | TREATMENT OF INFLAMMATORY LESIONS OF ROSACEA WITH IVERMECTIN - Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts. | 06-30-2016 |
20160200757 | TYLOSIN A ANALOGS AND DERIVATIVES | 07-14-2016 |
20160250244 | COMPOSITIONS FOR TREATING HEARTWORM INFESTATION | 09-01-2016 |
20160374994 | PARASITICIDAL ORAL VETERINARY COMPOSITIONS COMPRISING SYSTEMICALLY-ACTING ACTIVE AGENTS, METHODS AND USES THEREOF - This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. | 12-29-2016 |
20170232024 | PHARMACEUTICAL COMPOSITIONS FOR DEMODEX RELATED BLEPHARITIS AND EYELID CRUSTING | 08-17-2017 |
20170232026 | PHARMACEUTICAL COMPOSITION IN IVERMECTIN EMULGEL FOR VETERINARY USE AS A PROMOTER SYSTEM AND BIO-ADHESIVE IN ANTIPARASITIC TREATMENT, AND METHOD FOR THE PRODUCTION THEREOF | 08-17-2017 |
20190142817 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | 05-16-2019 |