Class / Patent application number | Description | Number of patent applications / Date published |
436528000 | Carrier is organic | 44 |
20080206893 | Biosensor and Method - Surface plasmon resonance (SPR) sensor biointerface with a rigid thiol linker layer and/or interaction layer ligand loading with reversible collapse and/or iron oxide nanoparticle sensor response amplification. | 08-28-2008 |
20080248594 | ORGANIC NON-SUGAR COMPOUNDS FOR PROTECTION OF BIOLOGICALLY ACTIVE MOLECULES AND CONJUGATE LABELS AND METHODS OF USE THEREOF - Provided are methods comprising the use of non-sugar organic compatible solutes for protection and preservation of the activity of biologically active molecules and conjugate labels. The methods are particularly adaptable for use in conjunction with immunoassays, such as for example, immunochromatographic test assays and may be incorporated into any test methodology wherein a dry test strip is used as a carrier for depositing, mobilizeable and/or immobilized biologically active molecules and/or conjugate labels. | 10-09-2008 |
20080261330 | Apparatus Components and Methods of Using Apparatus Components to Detect the Presence of an Analyte - Apparatus components including rigid supports suitable for use in an affinity column, affinity columns, and an affinity columns in fluid communication with an analytical column, such as in a high pressure liquid chromatography (HPLC) column, are disclosed. Methods of using the apparatus components to detect the presence of one or more analytes are also disclosed. | 10-23-2008 |
20080311679 | Biosensor Device - The invention relates to a biosensor device with an actuating element comprising a biorecognition element that is capable of binding target molecules from a sample of interest, wherein the actuating element comprises a polymer material, can be actuated by actuating means between a first and a second position. | 12-18-2008 |
20090017562 | RAMAN-ACTIVE REAGENTS - Raman Active Reagents (ERLs) are developed which use a nanoparticle substrate substantially covered with a mixed monolayer derived from a Raman active reporter molecule and an analyte binding molecule that both bind to the surface of the nanoparticle and thereby avoid the necessity for separate synthesis of a bifunctional linker molecule in making the ERL. | 01-15-2009 |
20090162946 | METHOD OF PREPARING A NANOPARTICLE FILM HAVING METAL IONS INCORPORATED - The present invention relates to a method of preparing a nanoparticle film having metal ions incorporated and to a film prepared by said method. The invention furthermore relates to uses of such a film. | 06-25-2009 |
20090286330 | Immunoassay using insoluble carrier particles and reagent therefor - The present invention provides a reagent for an immunoassay comprising insoluble carrier particles which can give the values to be determined with high accuracy and reliability, and can be stored for a long time; an immunoassay using the reagent; and a method for keeping the reagent stable. The present invention provides an immunoassay which comprises carrying out an antigen-antibody reaction using insoluble carrier particles in an aqueous medium comprising a buffer having its buffer capacity in a neutral or alkaline region (except for a carbonate-based buffer) and a carbonic acid compound releasing a bicarbonate ion; a reagent for an immunoassay comprising a buffer having its buffer capacity in a neutral or alkaline region (except for a carbonate-based buffer), a carbonic acid compound releasing bicarbonate ion, and insoluble carrier particles; and a method for keeping the reagent for an immunoassay comprising insoluble carrier particles stable, which comprises allowing insoluble carrier particles to co-exist in an aqueous medium comprising a buffer having its buffer capacity in a neutral or alkaline region (except for a carbonate-based buffer) and a carbonic acid compound releasing a bicarbonate ion. | 11-19-2009 |
20100029016 | Nano-Sized Optical Fluorescence Labels and Uses Thereof - A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a peptide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster and/or the generation of the dendrimer, and wherein said emission is used to provide information about a biological state. | 02-04-2010 |
20100093109 | PIEZO DISPENSING OF A DIAGNOSTIC LIQUID INTO MICROFLUIDIC DEVICES - Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device. | 04-15-2010 |
20100233827 | METHOD FOR PRODUCING MOLECULE IMMOBILIZING SUBSTRATE, AND MOLECULE IMMOBILIZING SUBSTRATE - There is disclosed a method for producing a molecule immobilizing substrate, comprising at least the steps of:
| 09-16-2010 |
20100240150 | MEASURING REAGENT AND TURBIDIMETRIC IMMUNOASSAY AND SAMPLE ANALYSIS TOOL USING THE SAME - A measuring reagent is provided that allows the amounts of insoluble carrier particles and monoclonal antibodies to be reduced, can improve measurement sensitivity with respect to an object to be measured in a low concentration range, allows the object to be measured in a wide concentration range, and is used for a turbidimetric immunoassay applicable to a sample analysis tool such as a test piece. The measuring reagent includes two types of insoluble carrier particle groups that are different in mean particle size from each other. The insoluble carrier particles contained in one insoluble carrier particle group support polyclonal antibodies and monoclonal antibodies, and the insoluble carrier particles contained in the other insoluble carrier particle group support at least one of the polyclonal antibodies and the monoclonal antibodies. Preferably, the former is an insoluble carrier particle group with a small mean particle size and the latter is an insoluble carrier particle group with a large mean particle size. | 09-23-2010 |
20100267170 | ROBUST, SELF-ASSEMBLED, BIOCOMPATIBLE FILMS - The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding. | 10-21-2010 |
20110045608 | Imatinib Immunoassay - Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids. | 02-24-2011 |
436529000 | Polysaccharide, carrier (e.g., dextran, etc.) | 11 |
20090035876 | Electrochemical Assay - A method of determining the presence or amount of analyte in a fluid sample, which comprises: contacting a fluid sample with a binding reagent that comprises a plurality of cleavable species and wherein said species, when cleaved, are detectable using electrochemical means; separating any binding reagent-analyte complex that forms from the unbound binding reagent; cleaving the cleavable species from the immobilized binding reagent-analyte complex; and detecting the cleaved species using electrochemical means. | 02-05-2009 |
20110033954 | BIOFUNCTIONALIZED QUANTUM DOTS FOR BIOLOGICAL IMAGING - Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a biofunctional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications. | 02-10-2011 |
20110129944 | WATER-SOLUBLE NANOCRYSTALS AND METHODS OF PREPARING THEM - Disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup IIb, subgroup VIIa, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule. Also disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup I1b, subgroup VI1a, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), and at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent is covalently linked to a water soluble host molecule. Also disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup I1b, subgroup VI1a, subgroup VI11a, subgroup 1b, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule. Finally, compositions and uses of such nanocrystals are disclosed. | 06-02-2011 |
20120196385 | ASSAY METHOD AND KIT FOR ASSAY EMPLOYING SENSOR CHIP FOR FLUORESCENT MEASURING APPARATUS UTILIZING SURFACE PLASMON-FIELD ENHANCED FLUORESCENCE SPECTROMETRY - An assay method with use of a sensor chip which includes a metal member, a self-assembled monolayer (SAM), and ligands on a support, and is configured to be used for a fluorescence measuring apparatus with utilization of a surface plasmon-field enhanced Fluorescence Spectrometry, including the steps of: forming a hydrophilic high molecule layer on the self-assembled monolayer in the sensor chip; immobilizing the ligands at least one of in the hydrophilic high molecule layer and on the surface of the hydrophilic high molecule layer; and bringing a moisturizer in contact with the hydrophilic high molecule layer. | 08-02-2012 |
436530000 | Cellulose or derivative | 7 |
20080305559 | Non-Competitive Immunoassays to Detect Small Molecules - The present invention provides noncompetitive immunoassays to detect small molecules. | 12-11-2008 |
20090087927 | IMMUNOCHROMATOGRAPHY METHOD USING FRAGMENTED ANTIBODY - An object of the present invention is to overcome the problem of nonspecific adsorption of a labeled antibody on the detection site and to provide an immunochromatography method by which the false positive signal can be suppressed, and wherein the detection sensitivity is high and the highly reliable measurement can be performed. The present invention provides an immunochromatography method, which comprises developing an analyte and a labeling substance modified with a first antibody against the analyte on a porous carrier in a state where the analyte and the labeling substance is mixed, and capturing the analyte and the labeling substance at the reaction site on the porous carrier having a second antibody against the analyte, so as to detect the analyte; wherein a fragmented antibody is used as the first antibody and/or the second antibody; an analyte is detected via amplification using an amplification solution which contains a compound containing silver and a reducing agent for silver ions; and the ratio of the non-specifically adsorbed labeling substance in the pre-amplification detection site and the non-detection site of the porous carrier is between 0.4 to 2.5 in a system where the density of the non-specifically adsorbed labeling substance is 10 | 04-02-2009 |
20090269858 | METHOD OF DETERMINING THE CONCENTRATION OF AN ANALYTE USING ANALYTE SENSOR MOLECULES COUPLED TO A POROUS MEMBRANE - The present invention relates to a method of determining the concentration of an analyte in a sample and/or the binding kinetics of an analyte to an analyte sensor molecule. For this purpose the invention relies on detecting the interaction between the analyte and the analyte sensor molecule with the latter being physically adsorbed to a solid, porous support which is in the form of a micro array. In a preferred embodiment, the method may be operated in repeated cycles. | 10-29-2009 |
20100112726 | RAPID IMMUNOCHROMATOGRAPHIC DETECTION BY AMPLIFICATION OF THE COLLOIDAL GOLD SIGNAL - The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in a sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device. | 05-06-2010 |
20110020954 | CELLULOSE DERIVATIVE FINE PARTICLE, DISPERSION LIQUID THEREOF, DISPERSION BODY THEREOF AND DIAGNOSTIC REAGENT - An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle. | 01-27-2011 |
20150031145 | ENHANCED FUNCTIONALITY AND DELIVERY OF A PROTEIN FROM A POROUS SUBSTRATE - Compositions, methods, articles of manufacture, and kits are provided for storage and delivery of proteins. | 01-29-2015 |
20150293082 | CELLULOSE DERIVATIVE FINE PARTICLE, DISPERSION LIQUID THEREOF, DISPERSION BODY THEREOF AND DIAGNOSTIC REAGENT - An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle. | 10-15-2015 |
436531000 | Carrier is synthetic resin | 20 |
20080206894 | Bioresponsive Hydrogels - The invention is a structure capable of detecting a target molecule, the invention including a functionalized polymer matrix having chemically reactive groups and at least one biomolecule attached to the chemically reactive groups to form a surface-modified bioresponsive polymer matrix. | 08-28-2008 |
20090029482 | FUNCTIONAL PARTICLE, AND METHOD FOR SEPARATION OF TARGET SUBSTANCE USING THE SAME - The particles of the present invention are high density particles which enable a preferential binding of a target substance thereto and inhibit a binding of “substances other than the target substance” thereto. The particles of the present invention are characterized in that a substance or functional group capable of binding to a target substance is immobilized on the surface of a particle body; the particles have a density of 3.5 g/cm | 01-29-2009 |
20090042318 | METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE - The present invention provides a solid phase carrier capable of adsorbing a highly hydrophobic target molecule, for example, a membrane associated protein, and a solid phase carrier optimized not only for a highly hydrophobic target molecule, but also for an optionally chosen target molecule. More specifically, the present invention provides a solid phase carrier having a ligand and a capping agent immobilized thereon, with the hydrophobic property of the surface thereof adjusted to enable the binding of the target molecule to the ligand, or to increase the amount of target molecule bound to the ligand; various methods using the solid phase carrier (for example, method of concentrating, isolating, or purifying a target molecule, a method of selectively adsorbing a particular target molecule to the solid phase carrier, or a method of analyzing the interaction between ligand and target molecule therefor); a production method for the solid phase carrier; and an improvement method for a solid phase carrier having a ligand and a capping agent immobilized thereon and the like. | 02-12-2009 |
20090075397 | Method for characterizing sugar-binding interactions of biomolecules - This invention provides a donor bead for use in an assay, wherein the bead (a) is coated with a layer of hydrogel having directly or indirectly bound thereto a polyacrylamide-supported sugar or a polyacrylamide-supported glycan, and (b) comprises a photosensitizer which, upon excitation by laser light of a suitable wavelength, converts ambient oxygen to singlet state oxygen. This invention also provides an acceptor bead for use in an assay, wherein the bead (a) is coated with a layer of hydrogel having directly or indirectly bound thereto a polyacrylamide-supported sugar or a polyacrylamide-supported glycan, and (b) comprises a chemiluminescer and a fluorophore, whereby when the bead is contacted with singlet state oxygen, the singlet state oxygen reacts with the chemiluminescer which in turn activates the fluorophore so as to cause the emission of light of a predetermined wavelength. This invention further provides related kits, detection methods and characterization methods. | 03-19-2009 |
20090137064 | LIGAND MOLECULE-IMMOBILIZED POLYMER, LIGAND MOLECULE-IMMOBILIZED PARTICLE, METHOD OF DETECTING TARGET SUBSTANCE, AND METHOD OF SEPARATING TARGET SUBSTANCE - A ligand molecule-immobilized polymer has a structure represented by the following general formula (1). | 05-28-2009 |
20090142856 | Use of unique fluorochromes in rapid test systems - The present invention includes an assay method for detecting an analyte in a sample. The assay includes a solid surface such as a nitrocellulose membrane. It also includes providing a sample is applied to the solid surface and detecting the presence or absence of the analyte using a fluorescent label from a lanthanide label. The invention also includes a device for detecting the fluorescence in or on an assay test strip. The device includes a housing, a solid surface and an ultraviolet radiation emitting LED. | 06-04-2009 |
20090203155 | LABELED PARTICLE OBTAINED BY IMMOBILIZING A FRAGMENTED ANTIBODY TO A LABELING SUBSTANCE - An object of the present invention is to provide a labeled particle having a high reactivity with an antigen and a suppressed non-specific adsorption, and an immunochromatographic method using the labeled particle. The present invention provides a labeled particle, wherein a fragmented antibody is immobilized to a labeling substance via a chemical bond. | 08-13-2009 |
20100151594 | COLLECTION OF MICRO SCALE DEVICES - A collection of one or more microfluidic devices which together carry a plurality of microchannel structures each of which comprises a reaction microcavity ( | 06-17-2010 |
20100233828 | Site Selectively Tagged and Templated Molecularly Imprinted Polymers for Sensor Applications - This invention provides molecularly imprinted polymers (MIPs) for the detection of analytes, methods for forming the MIPs and detecting the analyte using the MIPs. The MIP comprises templated sites which are formed using a mimic of the analyte such that a reporter compound can be selectively attached at the templated sites, thus providing a site selectively tagged and templated MIP. | 09-16-2010 |
20100304503 | PROCESS FOR PRODUCING POLYMER PARTICLES - A process for producing polymer particles having an antigen or an antibody introduced into the surface thereof, by carrying out miniemulsion polymerization using a monomer, a radical polymerization initiator, an emulsifier, and a hydrophobe in the presence of the antigen or antibody to thereby produce the polymer particles, is disclosed. According to the process, it is possible to provide a reagent for immunological analysis having an excellent detection sensitivity and capable of avoiding a nonspecific reaction which occurs in conventional methods. | 12-02-2010 |
20100330706 | PROBE IMMOBILIZATION AND SIGNAL AMPLIFICATION FOR POLYMER-BASED BIOSENSOR - The present invention provides methods of making polymer-based biosensors and the biosensors made by said methods, wherein the biosensors comprise conducting polymers and negatively charged nanoparticles comprising a capture moiety. The present invention also provides methods of detecting analytes in a solution by contacting the solution with said polymer-based biosensors. | 12-30-2010 |
20110151586 | POLYMER ENCAPSULATED PARTICLES AS SURFACE ENHANCED RAMAN SCATTERING PROBES - The present invention refers to a Raman active composite material comprising a metal particle; a coating layer of a Raman active molecule bound to the metal particle; and an encapsulating layer of an amphiphilic polymer bound to the metal particle. The present invention also refers to methods of manufacturing a Raman active composite material described herein and their uses. | 06-23-2011 |
20110195527 | METHODS AND DEVICES FOR ANALYTE DETECTION - Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials. | 08-11-2011 |
436532000 | Antigen or antibody attached to a carrier via bridging agent | 5 |
20080268551 | System and Method for Biological Assays - The present invention provides polymers and microfluidic devices comprising a covalently attached substrate binding element, and methods for producing and using the same. | 10-30-2008 |
20100159616 | Bio-Chip of Pattern-Arranged in Line, Method for Manufacturing the Same, and Method for Detecting an Analyte Bound in the Same - A bio-chip has a base plate, and a fluid resin layer positioned on the base plate and having a plurality of convexo-concave structures that are uniformly arranged in line. Side walls of the structures form reflecting films to form a Fabry-Perot interferometer structure. The bio-chip is used to detect an analyte provided to the bio-chip, so that it is possible to rapidly analyze the small amount of samples and to realize the detection sensitivity relatively higher than the conventional method. | 06-24-2010 |
436533000 | Carrier is water suspendible particles (e.g., latex, etc.) | 3 |
20100197042 | REAGENT AND METHOD FOR IMMUNOLOGICAL ANALYSIS - A reagent for immunological analysis, comprising a suspension of latex particles having an antigen or an antibody specific for a substance to be analyzed introduced into the surface of the latex particles, produced by polymerizing a monomer in the presence of the antigen or antibody to thereby synthesize the latex particles; and a method for immunological analysis, comprising the step of bringing, in a liquid, (1) a sample suspected of containing a substance to be analyzed, into contact with (2) latex particles having an antigen or an antibody specific for the substance introduced into the surface of the latex particles, produced by polymerizing a monomer in the presence of the antigen or antibody to thereby synthesize the latex particles; are disclosed. The reagent and the method have an excellent detection sensitivity, and can avoid a nonspecific reaction which occurs in conventional methods. | 08-05-2010 |
20100216257 | Method of Assaying Antigen and Reagent Therefor - A latex agglutination method by which the measurement range is extended and the sensitivity of the measurement in the low concentration range is increased, is disclosed. The method for measuring a test antigen by latex agglutination uses two types of large and small particles, having different average particle sizes. Each latex particle is sensitized with an antibody which undergoes antigen-antibody reaction with the test antigen. The purity of the antibody immobilized on the latex particles is within a specific range. The ratio of the amount of the antibody immobilized per one small latex particle to the amount of the antibody immobilized per one large latex particle; the average particle size of the large latex particles; the average particle size of the small latex particles; the concentration of the large sensitized latex particles in the antigen-antibody reaction system; and the concentration of the small sensitized latex particles in the reaction system are within a specific range. The large sensitized latex particles and the small sensitized latex particles are reacted with the test antigen in the state suspended in a buffer, and then the agglutination of the sensitized latex particles is optically measured. | 08-26-2010 |
20110104825 | METHOD FOR ENHANCING SENSITIVITY OR METHOD FOR AVOIDING INFLUENCE OF HEMOGLOBIN IN IMMUNOLOGICAL MEASUREMENT - To provide a technique for enhancing measurement sensitivity or a technique for avoiding a hemoglobin influence in an immunoassay method. | 05-05-2011 |
436534000 | Carrier is water suspendible particles | 2 |
20080268552 | CARBOXYLATED LATEX PARTICLES - The present invention relates to processes for preparing carboxylated latex particles based on the copolymerization of a monoalkenylaromatic monomer (A) and an aliphatic unsaturated carboxylic acid (B), where the copolymerization takes place at a pH in the range from pH >1.5 to pH <4.5. The pH is typically monitored during the copolymerization process and regulated by suitable compensatory titration. The invention likewise relates to the carboxylated latex particles obtainable by one of the processes according to the invention, and to the use of these particles in an immunological test method. | 10-30-2008 |
20090029483 | REAGENT FOR LATEX AGGREGATION REACTION AND METHOD FOR DETECTING TARGET SUBSTANCE - A reagent for latex aggregation reaction contains water-soluble polymer having a repeating unit presented by the following formula (1): | 01-29-2009 |