Class / Patent application number | Description | Number of patent applications / Date published |
435087000 | Nucleoside | 32 |
20090081735 | NOVEL PROCESS - Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine. | 03-26-2009 |
20100143978 | Process for Manufacture of Optically Active 2-(Acyloxymethyl)-1,3-Oxathiolanes - There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula I comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The invention may further provide for the esterification and racemization of the by-product of the enzymatic reaction. In this manner, 2(R)-(benzoyloxymethyl)-1,3-oxathiolane is prepared as a useful intermediate for manufacture of the anti-HIV drug Apricitabine. | 06-10-2010 |
20100159523 | Coryneform Bacteria Which Produce Chemical Compounds I - The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria. | 06-24-2010 |
20100255544 | CORYNEFORM BACTERIA WHICH PRODUCE CHEMICAL COMPOUNDS II - The invention relates to coryneform bacteria which, instead of the singular copy of an open reading frame (ORF), gene or allele naturally present at the particular desired site (locus), have at least two copies of the open reading frame (ORF), gene or allele in question, preferably in tandem arrangement, and optionally at least a third copy of the open reading frame (ORF), gene or allele in question at a further gene site, and processes for the preparation of chemical compounds by fermentation of these bacteria. | 10-07-2010 |
20110033898 | METHOD FOR PRODUCING 5'-GUANYLIC ACID - 5′-guanylic acid (GMP) is produced efficiently by allowing a microorganism to react with xanthylic acid (XMP), wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid and has been modified so that the nagD gene does not function normally and 5′-guanylic acid synthetase activity is enhanced. | 02-10-2011 |
20130137143 | SEMI-CONTINUOUS AND CONTINUOUS ENZYMATIC HYDROLYSIS PROCESS - The present invention relates to a semi-continuous or continuous process for the regioselective enzymatic hydrolysis of alcohol groups protected e.g. as esters or amino-acid esters or phosphate groups. The process of the present invention is useful for instance for the selective enzymatic hydrolysis of pyranosides or furanosides having more than one hydrolysable groups. | 05-30-2013 |
20150140610 | SULFILIMINE AND SULPHOXIDE METHODS FOR PRODUCING FESTINAVIR - A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on. | 05-21-2015 |
20160076070 | BIOCATALYTIC PRODUCTION OF NUCLEOSIDE ANALOGUES AS ACTIVE PHARMACEUTICAL INGREDIENTS - A biocatalytic process for producing active pharmaceutical ingredients (APIs) or intermediates thereof, wherein those APIs or their intermediates are nucleoside analogues (NAs) of formula I | 03-17-2016 |
435088000 | Having a fused ring containing a six-membered ring having two N-atoms in the same ring (e.g., purine nucleosides, etc.) | 24 |
20080241888 | Method for Producing Purine Nucleosides and Nucleotides by Fermentation Using Bacterium Belonging to the Genus Bacillus or Escherichia - Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5′-inosinic acid are provided which include using a bacterium belonging to the genus | 10-02-2008 |
20090104665 | PURINE-DERIVED SUBSTANCE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING A PURINE-DERIVED SUBSTANCE - A purine-derived substance is produced by culturing a bacterium belonging to the genus | 04-23-2009 |
20090186384 | Purine-Derived Substance-Producing Bacterium and a Method for Producing Purine-Derived Substance - A purine-derived substance is produced by culturing a | 07-23-2009 |
20090203080 | S-Adenosylmethionine Synthetase Mutants, the DNAs Encoding the Same and Uses of the Mutants - The invention discloses a series of | 08-13-2009 |
20090269812 | METHOD OF PRODUCING CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS - The invention provides a method of producing a chemical product through continuous fermentation which includes filtering a culture of a microorganism or cultured cells with a separation membrane to recover a product from a filtrate and simultaneously retaining a nonfiltered fluid in, or refluxing it to, the culture, and adding fermentation materials to the culture, wherein a porous membrane having an average pore size of 0.01 μm or more to less than 1 μm is used as the separation membrane and the filtration is conducted with a transmembrane pressure difference in the range of 0.1 to 20 kPa. According to this method, the fermentation productivity of the chemical product can be largely elevated at high stability and a low cost. | 10-29-2009 |
20090286284 | METHOD OF PURIFYING CYTIDINE DIPHOSPHATE CHOLINE - A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline. | 11-19-2009 |
20090298127 | METHOD FOR PRODUCING PURINE NUCLEOSIDES AND NUCLEOTIDES BY FERMENTATION USING A BACTERIUM BELONGING TO THE GENUS ESCHERICHIA OR BACILLUS - A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5′-purine nucleotide such as 5′-inosinic acid or 5′-guanylic acid, using a bacterium belonging to the either genus | 12-03-2009 |
20100047874 | PURINE-DERIVED SUBSTANCE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING A PURINE-DERIVED SUBSTANCE - A purine-derived substance is produced by culturing a bacterium belonging to the genus | 02-25-2010 |
20100081173 | Microorganism Producing Inosine and Method of Producing Inosine Using the Same - The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of | 04-01-2010 |
20100291632 | Method for the production of cladribine - A method for producing cladribine (2-chloro-2′-deoxyadenosine) comprising the steps of: | 11-18-2010 |
20110003342 | INOSINE PRODUCING MICROORGANISM BELONGING TO THE GENUS CORYNEBACTERIUM AND PROCESS OF PRODUCING INOSINE USING THE SAME - A microorganism of the genus | 01-06-2011 |
20110020875 | HYDROGENASE POLYPEPTIDE AND METHODS OF USE - Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H | 01-27-2011 |
20110223637 | METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL - The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO | 09-15-2011 |
20110229937 | CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE - Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from | 09-22-2011 |
20110318783 | Microorganism Producing Inosine and Method of Producing Inosine Using the Same - The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of | 12-29-2011 |
20120129222 | MUTANT FORMATE DEHYDROGENASE, GENE ENCODING THE SAME, AND METHOD FOR PRODUCING NADH - Durability of formate dehydrogenase is improved with the use of formate dehydrogenase exhibiting high specific activity that is unpredictable from conventional findings. A specific amino acid substitution is introduced into | 05-24-2012 |
20120264175 | THERMOSTABLE BIOCATALYST COMBINATION FOR NUCLEOSIDE SYNTHESIS - The present invention relates to a recombinant expression vector comprising: a) the sequence encoding a purine nucleoside phosphorylase (PNPase, E. C. 2.4.2.1), b) the sequence encoding a uridine phosphorylase (UPase, E. C. 2.4.2.3), c) or both; each of the sequences operably linked to one or more control sequences that direct the production of said phosphorylases in a suitable expression host; said sequences originating from the Archaea Thermoprotei class, characterized in that the PNPase is from | 10-18-2012 |
20130065279 | MICROORGANISMS FOR PRODUCING METHACRYLIC ACID AND METHACRYLATE ESTERS AND METHODS RELATED THERETO - The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. | 03-14-2013 |
20130095529 | Microorganism with Improved Production of 5'-Xanthosine Monophosphate and 5'-Guanine Monophosphate, and Production Method of 5'-Xanthosine Monophosphate and 5'-Guanine Monophosphate Using Same - The present invention relates to a microorganism with improved production of 5′-xanthosine monophosphate and 5′-guanine monophosphate, and more specifically, to a | 04-18-2013 |
20130273608 | METHOD OF PRODUCING COMPOUND ORIGINATING FROM POLYSACCHARIDE-BASED BIO-MASS - A method of producing a compound originating from a polysaccharide-based biomass includes at least one of a saccharification step that produces a sugar solution containing a monosaccharide and/or an oligosaccharide from a product obtainable by hydrolyzing the polysaccharide-based biomass; a fermentation step that ferments the sugar solution containing the monosaccharide and/or oligosaccharide originating from the polysaccharide-based biomass; and a treatment that removes a fermentation inhibitor with the use of a separation membrane having a glucose removal rate and an isopropyl alcohol removal rate which simultaneously satisfy the following relationships (I) and (II) when a 500 ppm aqueous glucose solution at pH 6.5 at 25° C. and a 500 ppm aqueous isopropyl alcohol solution at pH 6.5 at 25° C. are respectively permeated through the membrane at an operation pressure of 0.5 MPa, prior to the saccharification step and/or in the step prior to the fermentation step: | 10-17-2013 |
20140178937 | METHOD OF MANUFACTURING SUGAR SOLUTION - A method of producing a sugar liquid with a cellulose-containing biomass as a raw material includes (1) hydrolyzing a cellulose-containing biomass to produce an aqueous sugar solution, and (2) filtering the aqueous sugar solution obtain in (1) through an ultrafiltration membrane having a molecular weight cutoff of 600 to 2,000 to remove a fermentation inhibitor(s) into the permeate side and collect a sugar liquid from the feed side. | 06-26-2014 |
20140363847 | MICROORGANISM HAVING CARBON DIOXIDE FIXATION PATHWAY INTRODUCED THEREINTO - An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism. | 12-11-2014 |
20150050694 | METHOD OF STERILIZING SEPARATION MEMBRANE MODULE, METHOD OF PRODUCING CHEMICAL BY CONTINUOUS FERMENTATION, AND MEMBRANE SEPARATION-TYPE CONTINUOUS FERMENTATION APPARATUS - A method of sterilizing a separation membrane module using water vapor includes: a liquid supplying step of supplying a liquid having a boiling point of 80° C. or higher at atmospheric pressure to a secondary side of the separation membrane module such that a filling ratio of the liquid in a space surrounded by a filtration portion of a separation membrane is 70% or more, the filtration portion being used for filtration; a liquid sealing step of isolating the secondary side of the separation membrane module such that the filling ratio of the liquid supplied to the secondary side in the liquid supplying step is 70% or more; and a sterilization step of sterilizing the separation membrane module by supplying water vapor to a primary side of the separation membrane module while the secondary side of the separation membrane module is isolated. | 02-19-2015 |
20160002678 | YEAST HAVING IMPROVED PRODUCTIVITY AND METHOD OF PRODUCING PRODUCT - A recombinant yeast cell capable of consuming glucose at an increased rate, and a method of efficiently producing glycolysis-derived products using the recombinant yeast cell. | 01-07-2016 |