Class / Patent application number | Description | Number of patent applications / Date published |
435043000 | Preparing compound having a 1-thia-4-aza-bicyclo (3.2.0) heptane ring system (e.g., penicillin, etc.) | 33 |
20090075327 | Methods for improving secondary metabolite production in fungi - The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production. | 03-19-2009 |
20090208999 | Crystalline amoxicillin trihydrate powder - The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin trihydrate powder, said process comprising: crystallizing amoxicillin trihydrate from a solution containing dissolved amoxicillin; separating the crystals from said solution; and drying the separated crystals, resulting in crystalline powder having a bulk density higher than 0.45 g/ml. | 08-20-2009 |
20100009404 | PRODUCTION OF BETA-LACTAM ANTIBIOTICS - The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be prepared by contacting the amino acids hydroxyphenylglycine (Hpg) or phenylglycine (Pg), cystein (C) and valine (V) with a non-ribosomal peptide synthetase (NRPS) to effect formation of the tripeptide HpgCV or the tripeptide PgCV, the NRPS comprising a first module M1 specific for Hpg or Pg, a second module M2 specific for C and a third module M3 specific for V An IPNS is further provided having an improved activity in this conversion, as well as an NRPS catalysing the formation of the tripeptides. Also a host cell is provided capable of fermentatively producing β-lactam antibiotics with N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl side chains. | 01-14-2010 |
20110104748 | PROCESS FOR THE PREPARATION OF BETA-LACTAM COMPOUNDS - The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate. | 05-05-2011 |
20110189727 | METHOD FOR MODIFYING NON-STARCH CARBOHYDRATE MATERIAL USING PEROXIDASE ENZYME - A method for the modification of a material comprising a non-starch carbohydrate, which method comprises contacting said material comprising a non-starch carbohydrate with a polypeptide which has peroxidase activity and which is: a. a polypeptide comprising an amino acid sequence having at least 55% homology with an amino acid sequence set out in any one of: amino acids 21 to 513 of SEQ NO: 2; amino acids 20 to 510 of SEQ ID NO: 4; amino acids 1 to 493 of SEQ ID NO 6; or amino acids 1 to 491 of SEQ ID NO: 8 or b. a polypeptide encoded by a polynucleotide comprising the nucleotide sequence having at least 55% homology with a nucleotide sequence set out in any one of: nucleotides 61 to 1539 of SEQ ID NO: 1; nucleotides 58 to 1530 of SEQ ID NO: 3; nucleotides 1 to 1479 of SEQ ID NO: 5; or nucleotides 1 to 1473 of SEQ ID NO: 7. | 08-04-2011 |
20110256585 | MUTANT PENICILLIN G ACYLASES - The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acid positions A3, A77, A90, A144 A192, B24, B109, B148, B313, B460 and B488 according to the amino acid numbering of the | 10-20-2011 |
20120034648 | PENTOSE SUGAR FERMENTING CELL - The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product. | 02-09-2012 |
20120214196 | Polypeptides Having Glucoamylase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 08-23-2012 |
20120214197 | Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 08-23-2012 |
20120258489 | FUNGAL PROMOTERS FOR EXPRESSING A GENE IN A FUNGAL CELL - The present invention relates to isolated fungal promoter DNA sequences, to DNA constructs, vectors, and fungal host cells comprising these promoters in operative association with coding sequences encoding polypeptides. The present invention also relates to methods for expressing a gene and/or producing a polypeptide using the new promoters isolated. The present invention also relates to methods for altering the transcription level and/or regulation of an endogenous gene using the new promoter of the invention. | 10-11-2012 |
20120276585 | METHOD FOR PRODUCING FERMENTATION PRODUCTS FROM LIGNOCELLULOSE-CONTAINING MATERIAL - The present invention relates to a method for producing a hydrolysate of from lignocellulose-containing material, comprising pre-treatment with low temperature, hydrolysis and fermentation, wherein hydrolysis is performed by contacting the lignocellulose-containing material with an enzyme composition comprising at least 10% xylanase enzyme protein w/w%. | 11-01-2012 |
20130017571 | Pullulanase Variants and Uses Thereof - A truncated pullulanase variant of a parent pullulanase belonging to family GH57 comprising an X47 domain and the use thereof. | 01-17-2013 |
20130095522 | Processes For Producing Fermentation Products - The present invention relates to processes for producing fermentation products from starch-containing material, wherein liquefied mash is saccharified or pre-saccharified using a thermostable carbohydrate-source generating enzyme before fermentation or SSF. | 04-18-2013 |
20130157307 | Process of Producing A Fermentation Product - The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more deamidases are present in the fermentation medium. | 06-20-2013 |
20130273601 | PENTOSE AND GLUCOSE FERMENTING YEAST CELL - The present invention relates to a yeast cell comprising one or more exogenous genes of a pentose metabolic pathway non-native to the yeast cell wherein the yeast cell has a disruption of the hxk1, hxk2 glk1 and gal1 native in the yeast cell. The invention further relates to pentose and glucose fermenting yeast cell that is capable of simultaneous pentose and glucose consumption. | 10-17-2013 |
20140051119 | FUNGAL BETA-XYLOSIDASE VARIANTS - The present invention provides fungal xylanase and/or beta-xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase and/or beta-xylosidases, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. | 02-20-2014 |
20140106398 | VECTOR-HOST SYSTEM - The present invention relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell is a filamentous fungal cell. The invention also relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell comprises a recombinant polynucleotide construct comprising a polynucleotide encoding a biological compound of interest or a compound involved in the synthesis of a biological compound of interest. | 04-17-2014 |
20140134671 | EFFECTS OF ALTERATION OF EXPRESSION OF THE MtfA GENE AND ITS HOMOLOGS ON THE PRODUCTION OF FUNGAL SECONDARY METABOLITES - Many fungal secondary metabolites are of industrial interest, such as antibiotics, while others are undesirable compounds such as mycotoxins. Overexpression of mtfA enhances production of fungal compounds with applications in the medical field, and overexpression or impaired mtfA expression decreases the production of compounds that negatively affect health/agriculture/economy such as mycotoxins. | 05-15-2014 |
20140206035 | POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains. | 07-24-2014 |
20140315243 | PROCESSES FOR PRODUCING FERMENTATION PRODUCTS - The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase, a thermostable protease, and optionally a carbohydrate-source generating enzyme and/or pullulanase, are present and/or added during liquefaction. The invention also relates to compositions suitable for use in a process of the invention. | 10-23-2014 |
20150079627 | PROCESSES OF PRODUCING FERMENTATION PRODUCTS - The invention relates to processes of producing a fermentation product, comprising liquefying a starch containing material with an alpha-amylase; pre-saccharifying and/or saccharifying and fermenting using a fermentation organism in the presence of a carbohydrate source generating enzyme and a cellulolytic composition The invention also relates to methods of dewatering whole stillage. | 03-19-2015 |
20150079628 | STARCH PROCESS - The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said granular starch. | 03-19-2015 |
20150125902 | POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains. | 05-07-2015 |
20150125903 | FUNGAL XYLANASES AND XYLOSIDASES - The present invention provides fungal xylanase and/or xylosidase enzymes suitable for use in saccharification reactions. The present invention provides xylanase and xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase(s) and/or xylosidase(s), as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. In some embodiments, the xylanase and xylosidase enzyme(s) are | 05-07-2015 |
20150299681 | Polypeptides Having Glucoamylase Activity And Polynucleotides Encoding Same - The present invention relates to polypeptides having glucoamylase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 10-22-2015 |
20150307852 | METHOD FOR MANUFACTURING USEFUL SUBSTANCE IN WHICH HIGH-DENSITY CULTURED STRAIN OF FILAMENTOUS FUNGI IS USED - An object to be achieved by the present invention is to culture a filamentous fungus at a high density, thereby enabling mass production of a useful substance. The present invention provides a method of producing a substance, including the steps of: culturing a mutant filamentous fungus with no expression of α-1,3-glucan to allow the filamentous fungus to produce a substance; and collecting the resulting substance. | 10-29-2015 |
20160046916 | GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to glucoamylase variants having increased thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 02-18-2016 |
20160052846 | METHOD OF DEMULSIFYING AND PURIFYING ORGANIC PRODUCTS FROM AN EMULSION - This invention provides methods to demulsify organic products from emulsions, using demulsifying solvents which act as a combination of demulsifier and low volume extraction solvent. The methods can be applied to purify organic products such as fatty alcohols from emulsions including those generated from fermentation broths. | 02-25-2016 |
20160145592 | GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to glucoamylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 05-26-2016 |
20160177343 | Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same | 06-23-2016 |
20160201041 | ENZYME COMPOSITION AND USES THEREOF | 07-14-2016 |
435044000 | By desacylation of the substituent in 6-position | 1 |
20100143968 | PENICILLIN-G ACYLASES - The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes. | 06-10-2010 |
435045000 | By acylation of the substituent in 6-position | 1 |
20100190206 | PROCESS FOR THE PREPARATION OF IMMOBILIZED RECOMBINANT PENICILLIN ACYLASE CATALYST FROM ACHROMOBACTER SP. CCM 4824 EXPRESSED IN E. COLI BL 21 CCM 7394 AND ITS USE FOR THE SYNTHESIS OF BETA-LACTAM ANTIBIOTICS - The present invention discloses isolation of Penicillin Acylase (PA) from | 07-29-2010 |