Class / Patent application number | Description | Number of patent applications / Date published |
424780190 | Heterocyclic monomer | 37 |
20080305070 | RELEASABLE POLYMERIC CONJUGATES BASED ON ALIPHATIC BIODEGRADABLE LINKERS - Activated polymeric bicine derivatives such as, | 12-11-2008 |
20100111894 | METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION - Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. The present invention also relates to compositions and formulations comprising MetAP-2 inhibitors for oral administration or administration via routes such as topical or ocular administration. The present invention also provides methods to treat conditions associated with or related to the over-expression or over-activity of MetAP-2 by administering the compositions and formulations comprising MetAP-2 inhibitors as disclosed herein. | 05-06-2010 |
20130344023 | POLYMER-ACTIVE AGENT CONJUGATES - A polymer includes at least one monomeric unit represented by Formula I, II, or III: where X is CH | 12-26-2013 |
20140341839 | BIOCIDAL COATING - The invention relates to a biocidal composition comprising a carboxyl functional polymer and biocidal quaternary ammonium ions. The polymer is a copolymer comprising maleic acid monomer units and/or anions thereof and vinyl ether comonomer units. The composition may be in the form of a film on a surface or in the form of a solution. | 11-20-2014 |
20150315389 | ANTIMICROBIAL SURFACE COATINGS - The subject invention discloses curable polymeric N-halamine precursors which are useful for forming an antimicrobial surface coating on an object or article of manufacture. The present invention more specifically reveals a cross-linkable, water soluble polymer which is particularly useful for coating substrates and which can be activated to provide such substrates with antimicrobial and/or odor reducing characteristics, said cross-linkable polymer being comprised of amine, amide, or imide group containing repeat units and epoxide or methylol group containing repeat units, wherein the ratio of amine, amide or imide group containing repeat units to epoxide or methylol group containing repeat units is at least 2:1. | 11-05-2015 |
424780200 | Maleic anhydride monomer copolymerized with hydrocarbon monomer | 4 |
20110300096 | Polymers With Structure-Defined Functions - An alternating copolymer comprising a backbone of residues of a maleic anhydride derivative and those of a compound containing vinylic unsaturation, which also comprises residues of an active compound containing a nucleophilic group, bound to the backbone by a residue of the nucleophilic group, including such a copolymer comprising residues of an active compound containing an alcohol, thiol or amine group. The chemical and biological properties of actives, such as protease inhibitors, neurotransmitter drugs, and other small molecule active drugs, are enhanced, and new applications enabled. Also, artefacts, including a solid medical implant device, dressing or scaffold or a fluid adhesive or medicinal composition comprising such a polymer, and a method of use of such a polymer, including a method for the treatment or prophylaxis of wounds. | 12-08-2011 |
424780210 | Ring-opened product thereof | 3 |
20130039880 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY - The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein. | 02-14-2013 |
20130129665 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY - The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein. | 05-23-2013 |
20140044669 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY - The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein. | 02-13-2014 |
424780220 | Nitrogen heterocycle | 28 |
20140079663 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND A METHOD FOR THE PROPHYLAXIS AND TREATMENT OF THE ADHESION PROCESS - The invention relates to inhibitory compounds of a p38 MAP kinase having a structure of type (I)-(VII) which can be used for the treatment or prophylaxis of adhesion. Pharmaceutical compositions are disclosed containing an effective amount of the substance SB203580 or one or more of the conjugated compounds of type (I)-(VII) or a combination thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient. Also disclosed is the use of the substance SB203580 as an agent having anti-adhesion activity. Also disclosed is a method for the prophylaxis and/or treatment of a disease or a condition in which there is a possibility of the formation and/or growth of adhesions, which makes it possible to dispense with the additional administration of a preparation in the post-operative period. | 03-20-2014 |
20140308234 | DRUG DELIVERY POLYMER AND USES THEREOF - Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject. | 10-16-2014 |
20150071871 | BIO-SYNTHETIC MATRIX AND USES THEREOF - A bio-synthetic matrix comprising a hydrogel which is formed by cross-linking a synthetic polymer and a bio-polymer is provided. The matrix is robust, biocompatible and non-cytotoxic and is capable of supporting cell in-growth in vivo. The matrix can be tailored to further comprise one or more bioactive agents. The matrix may also comprise cells encapsulated and dispersed therein, which are capable of proliferating upon deposition of the matrix in vivo. Methods of preparing the bio-synthetic matrix and the use of the matrix in vivo for tissue engineering or drug delivery applications are also provided. | 03-12-2015 |
424780230 | Six-membered ring | 11 |
20090324536 | ANTIMICROBIAL POLYMERS AND COATINGS - Biocidal compounds have been synthesized and tested. These biocidal compounds have broad-spectrum efficacy and their biocidal properties are easily renewable. Illustrative examples of these biocidal compounds include N-halamine monomers and polymers and silver sulfadiazine polymers. These compounds can be used to add biocidal function to various materials and articles. | 12-31-2009 |
20110177020 | ANTI-MICROBIAL POLYURETHANE DISPERSION, METHOD FOR THE MANUFACTURE THEREOF, APPLICATION METHOD AND ARTICLES PROVIDED WITH AN ANTI-MICROBIAL COATING - Described is a water-borne polyurethane dispersion comprising: a. a neutralized polyurethane polymer which is the reaction product of a poly-isocyanate, a polyol, a C | 07-21-2011 |
20110286957 | MULTIBLOCK COPOLYMERS - Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof. | 11-24-2011 |
20120195847 | POLYMER CONJUGATES OF BIPHALIN PEPTIDES - The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer. | 08-02-2012 |
20120276040 | ANTIMICROBIAL COMPOSITIONS AND METHODS OF MAKING SAME - This invention relates to a process of making a group of silylated poly(N-alkyl-4-vinylpyridinium) quaternized salts suitable for use as coating materials for the treatment of substrate surfaces to impart an antimicrobial effect. | 11-01-2012 |
20130011362 | TARGETING MONOMERS AND POLYMERS HAVING TARGETING BLOCKS - Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof. | 01-10-2013 |
20130017167 | HYDROPHOBIC BLOCK CONJUGATED THERAPEUTIC AGENTS - Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof. | 01-17-2013 |
20160053038 | HYDROPHILIZED BACTERICIDAL POLYMERS - A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and/or wound dressings. | 02-25-2016 |
20160096963 | Anti-microbial polyurethane dispersion, method for the manufacture thereof, application method and articles provided with an anti-microbial coating - An anti-microbial copolymer is disclosed. The anti-microbial copolymer comprises building blocks [BB1] and [BB2]: | 04-07-2016 |
20160108160 | Polymer/Copper Combination for Targeted Cancer Therapy - Polymer/copper combination that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer. | 04-21-2016 |
20160168347 | Composite Carrier for Immobilization of Proteins, Polypeptides or Oligopeptides, Preparation Methods and Application Thereof | 06-16-2016 |
424780240 | N-Vinyl-2-pyrrolidone | 14 |
20100015083 | Method of producing pvp/fullerene complex and aqueous solution thereof - An aromatic hydrocarbon solution of a fullerene or a fullerene mixture is mixed with an ethanol solution of polyvinylpyrrolidone (PVP), water is added to the mixed solution, the solvent is removed and then an aqueous solution of a complex of a fullerene or a fullerene mixture with polyvinylpyrrolidone (PVP) is obtained. Under a condition free from a halogen, a PVP/fullerene complex excellent in manifestation of fullerene properties, stability and safety and an aqueous solution thereof are obtained. | 01-21-2010 |
20110142789 | Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis - Compositions and methods for diagnosis and treatment of ALS are provided. | 06-16-2011 |
20110165114 | DRUG DELIVERY COMPOSITION - There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition. | 07-07-2011 |
20130064786 | siRNA HYDROGEL AND METHOD FOR MANUFACTURING THE SAME - The present invention relates to siRNA hydrogel and a method for manufacturing the same, and more particularly, to siRNA hydrogel for targeted gene silencing, which is nano-structured for targeted gene silencing, and a method for manufacturing the same. | 03-14-2013 |
20130149277 | PTEROSTILBENE AND PVP GRAPE JUICE EXTRACT COMBINATION FOR TREATMENT OF METABOLIC, VASCULAR, AND NEURODEGENERATIVE DISORDERS - A pharmaceutical composition is provided comprising a therapeutically effective amount of pterostilbene, a therapeutically effective amount of a polyphenolic-PVP extract of grape juice, and a pharmaceutically acceptable carrier. The embodiments of the pharmaceutical compositions can have lipid lowering properties, or alternatively can have properties that can treat oxidative stress, by decreasing inflammation or inflammatory processes contributing to neurodegenerative diseases. A method of lowering lipid levels in an individual is also provided, comprising administering to the individual in need of such treatment a pharmaceutical composition including a therapeutically effective amount of pterostilbene, a therapeutically effective amount of a polyphenolic-PVP extract of grape juice, and a pharmaceutically acceptable carrier, wherein lipid levels are decreased. | 06-13-2013 |
20130189219 | N-TERMINALLY CHEMICALLY MODIFIED PROTEIN COMPOSITIONS AND METHODS - Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon. | 07-25-2013 |
20170232110 | CONJUGATE FOR TREATING MALARIA | 08-17-2017 |
424780250 | Complexed with molecular halogen or compound containing only halogen atoms | 7 |
20090074707 | Shaped body and method for production of said body - Water-dispersible or water-soluble polymers, particularly those of the family of compounds comprising the poloxamers or the polyesters or amphiphilic agents (emulsifiers), and also lipophilic materials are dispersed by melting the components at suitable temperatures with admixture of pharmaceutically active substances by mechanical procedures, i.e. a lipophilic dispers phase is distributed in a hydrophilic continuous polymer phase to form a stable dispersion. By controlled cooling, curing, and storage followed by high-pressure molding at defined temperatures and operating pressures there are produced, in addition to other types of shaped bodies, dispersed polymeric fatty sticks distinguished by particularly good fracture strength, flexibility, and variable time-specific dimensional stability. | 03-19-2009 |
20110280824 | Furanone Copolymers - The present disclosure provides copolymers including a first monomer including at least one phospholipid possessing at least one vinyl group and a second monomer including a furanone possessing vinyl and/or acrylate groups. Compositions, medical devices, and coatings including such copolymers are also provided. | 11-17-2011 |
20130251666 | POVIDONE IODINE, A NOVEL ALTERNATIVE PRESERVATIVE FOR OPHTHALMIC COMPOSITIONS - The invention includes a preserved ophthalmic preparation comprising povidone-iodine (PVP-I) at a concentration sufficient to preserve the ophthalmic preparation, and at least one member selected from the group consisting of a steroidal anti-inflammatory compound, a non-steroidal anti-inflammatory compound, an antibacterial compound, an anti-allergy compound, and an anti-glaucoma compound. The invention also includes adding PVP-I to an ophthalmic composition in order to preserve the composition, wherein the PVP-I is added at a concentration sufficient to preserve the composition. | 09-26-2013 |
20140072525 | Antimicrobial preparation and methods for making and using the same - An antibiofilm complex formed of a polyvinylpyrrolidone (PVP) backbone, iodine anchored to the PVP backbone, Rifampin anchored to the PVP backbone, and a second antibiotic selected from the group consisting of Tobramycin and Gentamicin anchored to the PVP backbone. | 03-13-2014 |
20140219949 | PHARMACEUTICAL COMPOSITIONS COMPRISING IODINE AND STEROID AND USES THEREOF FOR SINUS DISEASES - The present invention provides pharmaceutical compositions comprising an iodine-containing compound and a steroid, useful for treating a clinical symptom in a patient's airway (e.g., nose, lung, and sinus), as well as methods for using the same. | 08-07-2014 |
20140255334 | BONE GRAFT MATERIALS CONTAINING CALCIUM PHOSPHATE AND POVIDONE-IODINE - Described herein are materials and methods for reducing the risk of infection at a surgical site performed to restore or repair bone in an animal. Bone graft materials for implantation into a mammal are contemplated containing an antimicrobial agent. In one embodiment the bone graft material comprises both calcium phosphate and povidone-iodine as the antimicrobial agent. In another embodiment the bone graft material further comprises collagen. The bone graft materials are designed so as to maintain the structural integrity and/or handling characteristics of the material upon implantation into a bony site. Various methods for manufacturing the bone graft materials described herein are also contemplated. | 09-11-2014 |
20150050234 | POLYMERIC COMPOSITE MATERIALS WITH ANTIMICROBIAL AND BIODEGRADABLE PROPERTIES AND USES THEREOF - A composite material for the production of a medical device having an antiseptic action includes a matrix of alginate in which the complex of iodopovidone is dispersed. The composite material is used particularly for the production of films, micro-capsules, and suture threads with iodine controlled release. | 02-19-2015 |