Entries |
Document | Title | Date |
20080203319 | Multicapillary Multilaser Detection System - A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of electromagnetic radiation sources; a mirror for receiving electromagnetic radiation from the electromagnetic radiation sources and for reflecting the electromagnetic radiation to the sample volumes; a scanner attached to the mirror; a parabolic reflector for collecting sample electromagnetic radiation from the sample volumes, the sample electromagnetic radiation being generated as a result of interaction of the reflected electromagnetic radiation with the sample volumes; a plurality of filters for filtering the sample electromagnetic radiation; and a plurality of detectors for detecting sample electromagnetic radiation from the sample volumes, each of the detectors being configured to receive sample electromagnetic radiation that has passed through a corresponding one of the plurality of filters and generate a signal upon receipt of sample electromagnetic radiation. | 08-28-2008 |
20080217557 | Method and Apparatus For Analyzing a Dynamic Sample - A method of analysing a sample of biological material including components ( | 09-11-2008 |
20080217558 | Luminescence Sensor Comprising at Least Two Wire Grids - The present invention proposes a sub-wavelength luminescence sensor, such as e.g. a luminescence biosensor or a luminescence chemical sensor, comprising at least two wire grids ( | 09-11-2008 |
20080224067 | Laser forensic detection method and apparatus - A method for detecting traces of material on a surface for forensic evidence gathering is disclosed. The surface is periodically illuminated with laser radiation. Pairs of images of the surface are recorded with one image in each pair recorded while the surface is illuminated and the other being recorded while the surface is not being illuminated. The images in each pair are subtracted and a video signal is generated from the subtracted images. The video signal can be displayed on a display device or recorded for later display and examination. | 09-18-2008 |
20080230716 | DNA BIOSENSOR AND METHODS FOR MAKING AND USING THE SAME - Disclosed herein are biosensors and methods for making and using the same. In one embodiment, the sensor for detecting an analyte comprises: a substrate, recognition elements specific for the analyte, an excitation source, a detector, a chamber located between the substrate and the excitation source and between the substrate and the detector, and an emission filter. The recognition elements are tethered to the substrate such that the recognition elements can be exposed to a sample. The excitation source is capable of emitting a first light having a first light peak intensity at a first wavelength, wherein the first light can excite a luminophore to emit a second light when the recognition elements interact with the analyte. The detector is capable of detecting the second light emitted by the luminophore. The emission filter is capable of filtering in a band gap that includes the first light peak intensity. | 09-25-2008 |
20080230717 | PHOTOACOUSTIC INDICATORS - A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point. | 09-25-2008 |
20080230718 | Feedback control system - An optical sensor feedback control device is provided comprising a luminescent sensing film, an optical processor adjacent the sensing film capable of sinusoidally photoexciting the luminescent sensing film and detecting the luminescent emission resulting therefrom, and a control means in communication with the optical processor for control of the magnitude of the photoexcitation, to receive information regarding the luminescent emission resulting therefrom, and generation of an electrical signal for determination of the magnitude and phase shift of the luminescence relative to the photoexcitation. The device of the present invention further has an optical processor positioning means in communication with the control means and the optical processor for adjusting the physical position of the optical processor and/or light source in relation to the sensing film based on data received from the control means. In addition, a method of feedback control of an optical sensor is provided. | 09-25-2008 |
20080265176 | COMPOSITION, METHOD OF AUTHENTICATING, METHODS OF MAKING AUTHENTICATABLE COMPOSITIONS, AUTHENTICATABLE ARTICLES MADE THERE FROM - A composition comprising compound of formula I, a process for preparing the composition comprising compound of formula I, methods of authentication for an article comprising compound of formula I or compound of formula II, authentication technology for polymer based articles comprising compound of formula I or formula II, methods of facilitating such authentication and method of making articles capable of authentication. | 10-30-2008 |
20080272312 | Hyperspectral fluorescence and absorption bioimaging - A system and method of hyperspectral chemical imaging (fluorescence or absorption based) to provide an automated approach for a more detailed analysis of disease status of a biological sample. When a biological sample is labeled with a fluorescent or light-absorbing contrast-enhancing agent, interactions between the contrast-enhancing agent and one or more constituents (or cellular components) of the biological sample may be manifested through spectral contents of a plurality of regions in a hyperspectral chemical image of the sample. Observations of such manifestations through analysis of corresponding spectral contents may greatly assist a user (e.g., a pathologist) in detecting and differentiating diseased portions of the stained sample. Hyperspectral chemical imaging may allow to identify multiple cellular components within a biological sample and to image their distribution within the sample, thereby assisting a pathologist to successfully and more accurately identify diseased portion(s) of the sample for further diagnosis and treatment. | 11-06-2008 |
20080272313 | Luminescence Sensor Operating in Reflection Mode - The present invention relates to a luminescence sensor ( | 11-06-2008 |
20080283771 | SYSTEM AND METHOD OF COMBINING ULTRASOUND IMAGE ACQUISITION WITH FLUOROSCOPIC IMAGE ACQUISITION - A system and method to image an imaged subject is provided. The system comprises an ultrasound imaging system including an imaging probe operable to move internally and acquire ultrasound image data of the imaged subject, a fluoroscopic imaging system operable to acquire fluoroscopic image data of the imaged subject during image acquisition by the ultrasound imaging system, and a controller in communication with the ultrasound imaging system and the fluoroscopic imaging system. A display can be illustrative of the ultrasound image data acquired with the imaging probe in combination with a fluoroscopic imaging data acquired by the fluoroscopic imaging system. | 11-20-2008 |
20080283772 | Methods and systems for analyzing fluorescent materials with reduced authofluorescence - Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions | 11-20-2008 |
20080283773 | Particle or Cell Analyzer and Method - A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles. | 11-20-2008 |
20080290294 | System for Synchronous Detection of Fluorescence in a Drop - A method for producing a modulated optical signal from a droplet of a liquid medium. The method positions a droplet of liquid on a hydrophobic surface, in the path of an optical beam, and modulates the shape of the droplet on this surface, by electrowetting, to modulate the signal obtained after passing the optical beam through the droplet. | 11-27-2008 |
20080302976 | Sensor with Improved Signal-to Noise Ratio and Improved Accuracy - The present invention provides a sensor and a method for detecting an optically variable molecule ( | 12-11-2008 |
20080308746 | Optical Fluorescence Tomography - The invention relates to an optical fluorescence tomography system of biological targets. For increasing the resolution an the penetration depth of the impact radiation, in order to result a better depth signal, the biological target is supplied with a fluorescence dye (Material), bleachable by impact radiation, wherein a controllable dynamic tissue-wise bleaching-effect of the fluorescence dye is generated, so that by time dependant measuring of the maximum fluorescence response signal can be correlated to the actual selective bleaching front in depth. | 12-18-2008 |
20080315119 | Method of Analysing a Sample and Apparatus Therefor - A method for performing photo-modification of a biological sample, the method comprising: (a) irradiating the sample; (b) detecting one or more signals based on the irradiated sample; (c) using one or more processor means to analyze the detected signals and determine one or more irradiation parameters, and, (d) returning to (a) conditioned on the irradiation parameters. Thus modifications may be determined and executed interactively as an experiment progresses, and therefore directed towards specific structures and/or events identified as of particular interest in the course of the experiment. | 12-25-2008 |
20090008573 | LIGHT EMITTING DIODE ILLUMINATION SYSTEM - In various embodiments of the invention, a unique construction for Light Emitting Diodes (LEDs) with prisms and dyes and other optical elements can be used to generate a variety of light sources with different emission spectra. In an embodiment of the invention, reflected light can be redirected outward. In another embodiment of the invention, a white LED based light uses a blue LED and associated optics elements, including a high index glass prism or rod, a layer of dyed florescent polymer and an extraction-enhancing optical element or lens, such that all of the light emitted from with the dye layer can be directed outward. | 01-08-2009 |
20090020710 | SEMICONDUCTOR NANOCRYSTALS FOR TIME DOMAIN OPTICAL IMAGING - A method of performing high repetition rate laser time domain imaging employs as fluoroprobes semiconductor nanocrystals having a fluorescence lifetime less than the laser pulse separation, typically less than 5 ns. The nanocrystals of the invention have a core/shell structure and may be surface treated to increase radiative decay. CdSe/Zns nanocrystals are particularly suitable. | 01-22-2009 |
20090026386 | SYSTEM AND METHOD EMPLOYING PHOTOKINETIC TECHNIQUES IN CELL BIOLOGY IMAGING APPLICATIONS - A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components. | 01-29-2009 |
20090032734 | Detection of microorganisms with a fluorescence-based device - A device and method for detecting by fluorescence microbial growth from sample substances are disclosed. For example, a method for the detection of visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising exciting said at least one fluorescing compound with ultraviolet energy emitted from a light-emitting diode comprising wavelengths below 400 nanometers, and detecting a visible-band fluorescence signal generated by said at least one excited fluorescing compound with at least one light detector sensitive to electromagnetic energy comprising wavelengths greater than or equal to 400 nanometers wavelength. For example, a device for detecting visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising at least one ultraviolet light-emitting diode generating electromagnetic radiation comprising wavelengths below 400 nanometers and capable of exciting the at least one fluorescing compound, at least one light detector sensitive to electromagnetic energy comprising wavelengths greater than or equal to 400 nanometers wavelength for the detection of visible-band fluorescence signals generated by the at least one fluorescing compound. | 02-05-2009 |
20090032735 | Sensing Device, Sensing Apparatus, and Sensing Method - There are provided a sensing device, a sensing apparatus, and a sensing method capable of realizing effective multi-photon absorption and local plasmon enhancement function. The sensing device can realize a high multi-photon excitation efficiency and selectivity by accurately controlling the material, shape, size, interval, and direction of metal particles arranged on a substrate. By employing the sensing device in various sensing apparatuses such as a fluorescent sensing apparatus, it is possible to realize sensing of detection object material with a high sensibility. | 02-05-2009 |
20090032736 | Biochip reader and fluorometric imaging apparatus - The present invention provides a biochip reader for reading the image information of samples using a photodetector device, by irradiating a corresponding beam of excitation light at each site of a biochip on which a plurality of the samples are arranged at equal pitches, the biochip reader comprising: a microlens substrate provided with a plurality of microlenses to transform excitation light to be irradiated at the biochip into a multibeam; and a zoom lens located between the microlens substrate and the biochip and capable of projecting the multibeam while adjusting the pitch between sites of the biochip to the pitch of the multibeam. The present invention further provides a fluorometric imaging apparatus for detecting the image of a specimen by irradiating excitation light at samples on the specimen arranged in a two-dimensional manner and measuring fluorescent light produced from a fluorescent substance attached to the specimen, the fluorometric imaging apparatus comprising: a two-dimensional photodetector device for detecting excitation light passing through the specimen or reflecting off the surface thereof; and movement means for repositioning the specimen according to images observed on the photoreceptor device. | 02-05-2009 |
20090065709 | Laser Scanner Device - Relates to a laser scanner device ( | 03-12-2009 |
20090065710 | TRACE EVIDENCE DETECTION USING MULTIPLE LASER LIGHT SOURCES - A method for detecting trace evidence materials on a surface comprises irradiating the surface with radiation from two or more lasers emitting radiation at different wavelengths selected to stimulate luminescence in the trace materials. The evidence is detected by observing the surface through an optical filter arranged to transmit the luminescence, while blocking transmission of the laser radiation wavelengths reflected or scattered from the surface. | 03-12-2009 |
20090078886 | METHOD AND APPARATUS FOR CHECKING DOCUMENTS OF VALUE - The invention relates to a method and an apparatus for recognizing forged documents of value, wherein the documents of value are illuminated with clocked excitation light of a light source. Within the bright phase of the excitation light a first luminescence intensity is detected, within the dark phase a second luminescence intensity. Because of the afterglow of the light pulses there is a residual fluorescence, which distorts the luminescence intensity in the dark phase. By linking the second luminescence intensity with the first luminescence intensity, e.g. by subtracting a scaled first luminescence intensity, a corrected second luminescence intensity is determined, which substantially corresponds to the phosphorescence signal of the document of value. | 03-26-2009 |
20090084981 | High-resolution tracking of industrial process materials using trace incorporation of luminescent markers - A method of marking an industrial process material including selectively incorporating a luminescent marker onto and/or into the industrial process material in a trace amount insufficient to be optically detectable in the presence of ambient light but sufficient to be non-destructively optically detectable in and/or on the industrial proce material in situ in the field or on-site. The trace amount of the luminescent marker is used to track, identify authenticate the industrial process material for at least one of material control, inventory control, stock control, logistics control, quality control and pollution control. | 04-02-2009 |
20090090873 | Method and system for detection of contrast injection in fluoroscopic image sequences - A method and system for detecting a spatial and temporal location of a contrast injection in a fluoroscopic image sequence is disclosed. Training volumes generated by stacking a sequence of 2D fluoroscopic images in time order are annotated with ground truth contrast injection points. A heart rate is globally estimated for each training volume, and local frequency and phase is estimated in a neighborhood of the ground truth contrast injection point for each training volume. Frequency and phase invariant features are extracted from each training volume based on the heart rate, local frequency and phase, and a detector is trained based on the training volumes and the features extracted for each training volume. The detector can be used to detect the spatial and temporal location of a contrast injection in a fluoroscopic image sequence. | 04-09-2009 |
20090095919 | SYSTEM AND METHOD FOR MONITORING CELLULAR ACTIVITY - A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser microscope is provided to excite a region of the specimen and cause fluorescence to be radiated from the region. The radiating fluorescence is processed by a spectral analyzer to separate the fluorescence into respective wavelength bands. The respective bands of fluorescence are then collected by an array of detectors, with each detector receiving a corresponding one of the wavelength bands. | 04-16-2009 |
20090101837 | MULTILAYER IDENTIFICATION MARKER COMPOSITIONS - Multi-layer identification markers, which comprise at least two layers that contain combinations of absorbers and fluorescence emitters, are described. The multi-layer identification markers may have application as security markers and security coatings. | 04-23-2009 |
20090101838 | Ionizing-radiation-responsive compositions, methods, and systems - A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses. | 04-23-2009 |
20090101839 | LASER SCANNER APPARATUS FOR FLUORESCENCE MEASUREMENTS - The invention relates to a laser scanner apparatus ( | 04-23-2009 |
20090134342 | High spatial resolution imaging of a structure of interest in a specimen - For the high spatial resolution imaging of a structure of interest in a specimen, a substance is selected from a group of substances which have a fluorescent first state and a nonfluorescent second state; which can be converted fractionally from their first state into their second state by light which excites them into fluorescence, and which return from their second state into their first state; the specimen's structure of interest is imaged onto a sensor array, a spatial resolution limit of the imaging being greater (i.e. worse) than an average spacing between closest neighboring molecules of the substance in the specimen; the specimen is exposed to light in a region which has dimensions larger than the spatial resolution limit, fractions of the substance alternately being excited by the light to emit fluorescent light and converted into their second state, and at least 10% of the molecules of the substance that are respectively in the first state lying at a distance from their closest neighboring molecules in the first state which is greater than the spatial resolution limit; and the fluorescent light, which is spontaneously emitted by the substance from the region, is registered in a plurality of images recorded by the sensor array during continued exposure of the specimen to the light. | 05-28-2009 |
20090146078 | SYSTEMS AND METHODS FOR EXTENDING THE USEFUL LIFE OF OPTICAL SENSORS - The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules. | 06-11-2009 |
20090159815 | FLUORESCENCE OBSERVATION OR FLUORESCENCE MEASURING SYSTEM AND METHOD - The fluorescence observation or fluorescence photometry system uses an optical base material having low autofluorescence and good adhesive property to cell. Said optical base material has the following optical characteristics: | 06-25-2009 |
20090173889 | Fluorescent photopolymerizable resins and uses thereof - There is provided fluorescent photopolymerizable resins for use in biological studies and image acquisition. In particular the photopolymerizable resins are useful in studying the properties of cells. The resins are also useful for the calibration of microscopic measurement systems. | 07-09-2009 |
20090184257 | APPARATUS AND METHOD FOR MEASURING AND/OR CONTROLLING ULTRAVIOLET-ACTIVATED MATERIALS IN A PAPER-MAKING PROCESS - A method includes illuminating a mixture of materials in a wet-end of a paper process, where the mixture includes an ultraviolet-activated material. The method also includes measuring light from the mixture and determining a property of the ultraviolet-activated material based on the measured light. The method may further include adjusting an operation in the wet-end of the paper process based on the determined property of the ultraviolet-activated material. The determined property could include a quantity of fluorescent material in recycled material used to form stock for a paper machine and/or a quantity of fluorescent material in stock provided to a headbox in the paper process. Adjusting the operation in the wet-end could include adjusting an amount of one or more materials used to form stock provided to the headbox, such as a fluorescent whitening agent, fixative, fluorescent fiber, fluorescent pigment, fluorescent particle, fluorescent highlight, fluorescent planchette, or fluorescent quencher. | 07-23-2009 |
20090189089 | VALVE CONTROL SYSTEM FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE - Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser. | 07-30-2009 |
20090194707 | MICROFLUIDIC IMMUNOASSAY DEVICE - An optical fiber for use in an immunoassay device having at least one microfluidic channel, the optical fiber being for transmitting excitation light to the microfluidic channel and for transmitting emitted fluorescence to a light detector. | 08-06-2009 |
20090206277 | Nanoparticles as agents for imaging finger prints - This invention relates to a novel analytical method for detecting prints, for example fingerprints, and to nanoparticles suitable for conducting such methods. | 08-20-2009 |
20090206278 | PHOTO-OPTICAL-ELECTRONIC GAS, PRESSURE AND TEMPERATURE SENSOR - A sensor according to the invention includes a surface having a sensing material that is responsive to a change in an environmental condition when illuminated. An illumination source is positioned to illuminate the surface. A receiver is positioned to receive light emanating from the surface; and a detector detects a change in light received at the receiver. | 08-20-2009 |
20090212235 | SCANNING FLUORESCENT READER WITH DIFFUSER SYSTEM - A fluorescence detection apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. The excitation light generator includes a diffuser to provide a more uniform light distribution. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module can interrogate different wells while in motion over the wells. | 08-27-2009 |
20090218514 | MULTI-SPOT INVESTIGATION APPARATUS - The invention relates to a method and an apparatus for the investigation of a sample material by multiple sample light spots ( | 09-03-2009 |
20090218515 | ELIMINATING FLUORESCENCE BACKGROUND NOISE - A method for measuring a fluorescent sample on a substrate. The method includes exciting the fluorescent sample with an exciting light source for the generation of a sample fluorescent optical signal and a substrate fluorescent optical signal substantially eliminated. The microfluidic substrate fluorescent optical signal is leaving the sample fluorescent optical signal. The sample fluorescence optical signal can then be processed. | 09-03-2009 |
20090218516 | Ratiometric Surface Plasmon Coupled Emission Detector - The present invention includes methods for ratiometric detection of analytes by surface plasmon coupled emission detection that includes disposing a target on the metal layer of a surface plasmon resonance detection system; coupling a first analyte to a first fluorescent dye and a second analyte to a second fluorescent dye; contacting the first and second analytes to the target on the surface plasmon resonance detection system; and measuring the intensity of a first and a second surface plasmon resonance enhanced fluorescence emission ring, wherein the first and second rings, respectively, quantitatively represents the amount of first and second analyte within 50 nanometers of the metal surface. | 09-03-2009 |
20090218517 | MULTIPLEX FLUORESCENCE DETECTION DEVICE HAVING REMOVABLE OPTICAL MODULES - Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules. Each of the removable optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. | 09-03-2009 |
20090224174 | Calibration device and laser scanning microscope with such a calibration device - A calibration device for managing a variety of performance tests and/or calibration tasks in a laser scanning microscope. The calibration device, which has focusing optics and a test structure arranged in the focal plane of the focusing optics, with structural elements detectable in reflected and/or transmitted light aligned to each other in a common mounting, can be switched into the microscope beam path in a laser scanning microscope, so that the pupil of the focusing optics coincides with the objective pupil of the laser scanning microscope or lies in a plane conjugated to it. | 09-10-2009 |
20090230322 | FLUORESCENCE BASED DETECTION OF SUBSTANCES - A method for the fluorescent detection of a substance, the method comprising providing particles comprising a metal or a metal oxide core, wherein one or more optionally fluorescently tagged antibodies or human specific peptide nucleic acid (PNA) oligomers for binding to a substance is/are bound, directly or indirectly, to the surface of the metal or metal oxide; contacting a substrate, which may or may not have the substance on its surface, with the particles for a time sufficient to allow the antibody/PNA oligomer to bind with the substance; removing those particles which have not bound to the substrate; if the antibodies or PNA oligomers are not fluorescently tagged, contacting the substrate with one or more fluorophores that selectively bind with the antibody and/or substance, then optionally washing the substrate to remove unbound fluorophores; and illuminating the substrate with appropriate radiation to show the fluorophores on the substrate. | 09-17-2009 |
20090230323 | Fluorometer with low heat-generating light source - This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a plurality of sample containers, such as capped PCR tubes in a standard titer tray. The fluorometer of the present invention further comprises an optical path between each LED and its correspondingly positioned container, and another optical path between each fluorescing sample within the positioned container and an optical signal sensing means. The instrument can be computer controlled. | 09-17-2009 |
20090230324 | Methods and Devices for Characterizing Particles in Clear and Turbid Media - The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection. | 09-17-2009 |
20090236542 | OPTICAL INSPECTION - This invention relates to methods of determining physical characteristics of and identifying and locating defects in substrates, such as semiconductor wafers, optical thin films, display screens and the like. The method involve use of PC scanners to image the substrate. In particular PC scanners used in transmission mode imaging allow information about the volume of the substrate to be determined. The method allows determination of characteristics such as layer thickness, curvature and optical constants through use of interferometery techniques and bifrefringence and strain through use of polarised imaging. The methods also relate to stimulating luminescence in the substrate, for example photoluminescence and electroluminescence and scanning the stimulated substrate for luminescence mapping. | 09-24-2009 |
20090236543 | Fluorescence Detection Using Lyman-alpha Line Illumination - A method and system is provided that takes advantage of the atmospheric transmission properties of the Hydrogen Lyman-α radiation line (121.6 nm wavelength) to illuminate a sample with high energy VUV photons at least partially in an atmospheric environment. Thus, according to the principles of the present invention, a sample is illuminated by radiation at the Hydrogen Lyman-α radiation line (121.6 nm wavelength), at least partially in an atmospheric environment, and luminescent radiation from the sample at longer wavelengths is detected. The high energy illuminating photons generate luminescent radiation from the sample at longer wavelengths, typically in the visible wavelength range, and this radiation can then be imaged, e.g. with a normal visible microscope. | 09-24-2009 |
20090242799 | METHOD FOR THE DETECTION OF BIOLOGIC PARTICLE CONTAMINATION - Methods for detecting particles in a fluid, including determining particle size and intrinsic fluorescence of a particle, and time correlating the particle detection data with image data in the vicinity of the detector or detector inlet to identify contamination sources in clean environments are described. | 10-01-2009 |
20090242800 | Electron-beam dimension measuring apparatus and electron-beam dimension measuring method - An electron-beam dimension measuring apparatus includes: electron-beam irradiating means for irradiating a surface of a sample with an electron beam; a stage on which the sample is placed; a photoelectron generating electrode disposed so as to face the sample; ultraviolet light irradiating means for emitting ultraviolet light; and control means for causing the ultraviolet light irradiating means to irradiate the sample and the photoelectron generating electrode with the ultraviolet light for a predetermined length of time, to cause the sample and the photoelectron generating electrode to emit photoelectrons, for applying a voltage to the photoelectron generating electrode, the voltage applied to supply energy corresponding to a difference between energy of photoelectrons emitted by the sample and energy of photoelectrons emitted by the photoelectron generating electrode, and thereby for controlling an electric potential of the surface of the sample to set the electric potential at 0 V. The control means measures the dimension of the sample after keeping the electric potential constant on the surface of the sample. | 10-01-2009 |
20090242801 | METHOD OF FLUORESCENCE-MICROSCOPICALLY IMAGING A STRUCTURE IN A SAMPLE WITH HIGH THREE-DIMENSIONAL SPATIAL RESOLUTION - For imaging a structure in a sample with three-dimensional spatial resolution, a fluorophore is selected which is transferable by means of an optical transfer signal out of a first into a second photochromic state having specific fluorescence properties, and which displays a return rate back into the first photochromic state. The structure is labeled with the fluorophore. Via a common objective, the sample with the labeled structure is subjected both to the optical transfer signal in a spatially limited transfer-volume, and to an optical excitation signal exciting a portion of the fluorophore being in its second photochromic state for fluorescence in a spatially limited excitation-volume, the transfer-volume and the excitation-volume having a common centre of maximum intensity of the transfer signal and of the excitation signal, and a decrease of intensity of the transfer signal with the distance to the common centre of maximum intensity being substantially stronger than any decrease of the effective return rate of the fluorophore. Fluorescence light emitted by the excited fluorophore is detected. The common centre of maximum intensity is shifted with regard to the sample; and the steps of subjecting and detecting are repeated. | 10-01-2009 |
20090242802 | FLOURESCENCE DETECTING METHOD AND FLUORESCENCE DETECTING APPARATUS - An excitation light beam of a wavelength that excites fluorescent labels and a reference light beam having a wavelength longer than the excitation light beam are irradiated through a dielectric block toward an interface between the dielectric block and a metal film, to cause a first electric field enhancing field and a second electric field enhancing field on the upper surface of the metal film, in fluorescence detection that utilizes surface plasmon. The intensity of scattered light of the second electric field enhancing field, which is substantially proportionate to the intensity of the second electric field enhancing field, is employed to normalize and correct the intensity of fluorescence emitted by fluorescent labels with respect to the intensity of the first electric field enhancing field, based on the relationship between the intensities of the first and second electric field enhancing fields. | 10-01-2009 |
20090250629 | Methods for Detecting Fluorescent Signals in a Biological Sample - Operational means for automatic microscopic detection and analysis of fluorescent signals from a treated biological sample. | 10-08-2009 |
20090250630 | PHOTODIODE FOR DETECTION WITHIN MOLECULAR DIAGNOSTICS - A photodiode ( | 10-08-2009 |
20090250631 | APPARATUS AND METHOD FOR FLUORESCENCE IMAGING AND TOMOGRAPHY USING SPATIALLY STRUCTURED ILLUMINATION - An imaging system is disclosed for imaging an object. More specifically, an improvement is disclosed in an imaging system enabling depth sectioned fluorescence imaging in a turbid medium, such as human or animal tissue, in such a manner as to substantially minimize the excitation radiation from reaching the detection beam path. The imaging system includes an arrangement of the excitation radiation source such that the optical axis of the source is inclined relative to the optical axis of the camera, the optical plane of the source and the optical plane of the object are subject to a Scheimpflug condition provided by projection optics, and the angle of inclination of the source is selected such that the excitation radiation incident upon the object is reflected in such a way that substantially minimizes excitation radiation from reaching the detection beam path. | 10-08-2009 |
20090250632 | Method and Arrangement for Collimated Microscopic Imaging - A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions. | 10-08-2009 |
20090256083 | Zirconium Dioxide Luminescence Oxygen Sensor - A method of measuring oxygen partial pressure in gases, such as hot engine exhaust gases, uses a calibrated luminescence sensor and comprises the steps of bringing nanocrystalline zirconinum dioxide ZrO | 10-15-2009 |
20090261269 | OPTICAL SIGNAL DETECTION METHOD, APPARATUS, SAMPLE CELL AND KIT - A sensor chip includes a dielectric plate and a sensor portion having a metal layer deposited on a predetermined area on the dielectric plate. A photo-reactable labeling-substance of an amount corresponding to the amount of a substance to be detected in a sample binds to the sensor portion by contacting the sample with the sensor portion. The amount of the substance to be detected is obtained by irradiating the predetermined area with excitation light and by detecting light output from the photo-reactable labeling-substance in an enhanced electric field that has been generated on the metal layer by irradiation with the excitation light. The photo-reactable labeling-substance includes a photo-reactable substance enclosed by a light transmissive material that transmits light output from the photo-reactable substance to prevent metal quenching that occurs when the photo-reactable substance is located close to the metal layer. | 10-22-2009 |
20090261270 | Monitoring Cleaning of Surfaces - A method for monitoring cleaning of a surface includes applying an amount of transparent indicator material to an area of a surface and measuring the amount of transparent indicator material remaining on the surface. The transparent indicator material may be fixed on the surface by drying and, when a fluorescent material, may be measured through exposure to ultraviolet radiation. | 10-22-2009 |
20090266999 | Apparatus and method for fluorescent imaging - An apparatus and method for fluorescent imaging. The apparatus includes a light-generating means for generating at least one modulated fluorescence excitation beam, a light retransmitting means for retransmitting the fluorescence excitation beam onto an area that is to be examined, a light-imaging means for imaging a fluorescent beam from the area to be examined onto a first image sensor, a control and evaluation means for controlling the light-generating means to power the first image sensor and for evaluating the data supplied by the first image sensor to generate a fluorescent image, where the fluorescent excitation beam may be continuously modulated, the first image sensor is a solid state detector that may be powered phase-sensitively, and the data supplied by the first image sensor contain pixel by pixel phase information on the fluorescent beam. | 10-29-2009 |
20090272913 | FLUORESCENT ORGANIC NANOPARTICLES - A nanoparticle having a surfactant shell with a hydrophilic outer surface and a hydrophobic inner surface and an organic chromophore and a polymer having aromatic groups within the surfactant shell. A method of making nanoparticles by: emulsifying an aqueous composition of a surfactant and an organic solution of a monomer and an organic chromophore to form micelles of the monomer and the chromophore inside a surfactant shell; and polymerizing the monomer. A method of: reacting a ω-bromoalkyl acid with acryloyl acid lithium salt, and reacting the product with sodium hydride to produce an acryloyloxyalkyl carboxylic acid sodium salt. The compound shown below. | 11-05-2009 |
20090272914 | COMPENSATOR FOR MULTIPLE SURFACE IMAGING - A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may, for instance, be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The captured and detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection (TIR) methods may benefit from the techniques of the present invention. In addition, the biological samples imaged may be present on the surfaces of the support structure in a random special pattern and need not be at known locations in order for the imaging to be performed. | 11-05-2009 |
20090283699 | FREQUENCY DOMAIN LUMINESCENCE INSTRUMENTATION - Instrumentation for measuring luminescence phase lag to quantitate an analyte concentration is corrected to eliminate or reduce extraneous phase lag noise. A calibration factor is determined in steps that are interspersed between quantitative measurements. An optical pathway is provided to accomplish the calibration by the provision of a second optical source that emits in the luminescence emission band of a luminescent material. The calibration factor may be subtracted from measurement of the quantification phase lag to correct for extraneous phase lag. | 11-19-2009 |
20090283700 | FLUORESCENCE DETECTING METHOD - A fluorescence detecting method utilizes surface plasmon enhancement. An electric field enhancing field is caused to be generated at a detecting portion that includes a metal film provided on a surface of a dielectric prism. Fluorescence emitted by fluorescent labels, which are attached to a detection target substance, due to the excitation effect of the electric field enhancing field is detected by a photodetector. During the detection, a plurality of fine metal particles are dispersed on the detecting portion. | 11-19-2009 |
20090289199 | Use of Fluorescent Nanoparticles to Measure Individual Layer Thicknesses or Composition in Multi-layer Films and to Calibrate Secondary Measurement Devices - Fluorescent nanoparticles such as quantum dots are incorporated into plastic, paper and other web layered products to achieve cross-direction and machine direction on-line analysis of the individual layers therein. Fluorescent nanoparticles markers are added in known proportions into product formulations. By detecting the fluorescence from the nanoparticles, the thickness and other physical characteristics of the web can be traced at various stages of production. In addition, by using different populations of fluorescent nanoparticles that emit radiation at different wavelengths, data from individual layers in a composite structure can be ascertained simultaneously with a single sensor. The technique is particularly suited for monitoring difficult-to-measure polymers in complex multilayer structures. | 11-26-2009 |
20090289200 | Fluorescent image obtainment method and apparatus, fluorescence endoscope, and excitation-light unit - A fluorescent image obtainment apparatus includes a light illumination means that illuminates a region to be observed with illumination-light and excitation-light at the same time, and an imaging means that captures an image composed of light reflected from the region illuminated with the illumination-light and an image composed of fluorescence output from the region illuminated with the excitation-light. Further, the apparatus includes an image processing means that produces an ordinary image based on the image of the reflection light and a fluorescent image based on the image of fluorescence, and a light amount control means that controls the light amount of the illumination-light so that a representative luminance value of the ordinary image becomes a predetermined luminance value and the light amount of the excitation-light so that the ratio of the light amount of the excitation-light to that of the illumination-light becomes a predetermined ratio. | 11-26-2009 |
20090289201 | COMBINED VISUAL/FLUORESCENCE ANALYTE DETECTION TEST - The sensitivity of visually read lateral flow immunoassay tests is enhanced by adding a small quantity of fluorescing dye or fluorescing latex bead conjugates to the initial conjugate material. When the visible spectrum test line is visibly present, the test result is observed and recorded. However, in the case where the result is indeterminate, a light of an appropriate spectrum, such as a UV, visible, or infrared spectrum, is cast on the test line to excite and fluoresce the fluorescing latex beads which are bound in the test line in true positive tests to enhance the visible color at the test line. | 11-26-2009 |
20090294691 | Method for Improving the Detection of Fluorescence Signals During a Resonance Energy Transfer - The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium. | 12-03-2009 |
20090294692 | PLASMONIC ASSISTED SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE - A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent. | 12-03-2009 |
20090294693 | APPARATUS AND METHOD FOR OPTICAL EXAMINATION OF DOCUMENTS - An apparatus for optical examination of documents. The apparatus includes a light source, a viewing unit having a window through which light emitted from the light source exits for examination of documents by an observer. A method for optical examination of a document. The method steps include: providing a light source; emitting light from the light source into a viewing unit; emitting light from the viewing unit through a window; applying fluid to a document to be viewed; and, bringing the document into contact with the window such that an observer can examine the document. | 12-03-2009 |
20090309044 | Luminescent Composition - The invention relates to a luminescent composition which is based on yttrium oxide sulfide and other oxide sulfides and to which at least one doping agent is added. The inventive composition has a characteristic emission spectrum and can optionally be used along with a reading system that is adjusted to the emission spectrum in order to mark substances or substance mixtures. | 12-17-2009 |
20090314957 | Branched Compounds And Their Use in Sensors - The invention provides sensors comprising one or more compounds of formulae (I) and (II): | 12-24-2009 |
20090321659 | METHOD FOR ON-SITE DRUG DETECTION IN ILLICIT DRUG SAMPLES - The invention is intended for illicit drug detection, preferably to Cocaine detection in street samples containing in addition to Cocaine also adulterants and/or diluents (also denominated as cutting agents) used for increasing the quantity of the product and/or for disguising the existence of Cocaine. The invention provides preparing of the liquid street sample, taking an aliquot of said sample, its analysis with help of SFS (Spectral Fluorescence Signatures) technology, fixing the result of analysis as a reference value, the subsequent acidification of the liquid sample, taking an aliquot of the acidified liquid sample and its analysis with help of SFS technology, fixing the result of analysis and comparing said result with the reference value. The result of comparison enables to differentiate between Cocaine Base and Cocaine hydrochloride in the street sample. | 12-31-2009 |
20090321660 | DISPERSIONS OF LUMINESCENT RARE-EARTH OXIDE PARTICLES, VARNISH COMPRISING THESE PARTICLES, THEIR METHODS OF PREPARATION AND METHOD FOR MARKING SUBSTRATES - Dispersion of particles of at least one oxide of at least one luminescent rare earth, disaggregated and stabilized in a hydrophobic liquid medium containing at least one surfactant, in which the said surfactant is a non-ionic surfactant having an HLB (hydrophilic-to-lipophilic balance) lower than 12. | 12-31-2009 |
20090321661 | DETECTING METHOD, DETECTION SAMPLE CELL, AND DETECTING KIT - A fluorescent substance having fluorescent pigment molecules, which are enveloped in a light transmitting material that transmits fluorescence generated by the fluorescent pigment molecules, is employed as fluorescent labels in a detecting method the detects the amount of a detection target substance based on the amount of light which is generated due to excitation of the fluorescent labels. The fluorescent substance is excited by evanescent waves which are generated due to leakage from an optical waveguide mode. | 12-31-2009 |
20090321662 | DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a sample binds to the sensor-portion when the sample is placed in contact with the sensor-portion. The sensor-portion is irradiated with excitation-light to generate an enhanced electric-field on the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance in the enhanced electric-field. A magnetic-particle is added to the fluorescent-label binding-substance, and the amount of the detection target substance is detected while the fluorescent-label binding-substance modified with the magnetic-particle is attracted to the vicinity of the sensor-portion by a magnetic-field application means arranged on an opposite-surface side of the dielectric-plate, opposite to the metal-layer-deposited surface thereof. | 12-31-2009 |
20100001208 | METHOD FOR QUANTITATIVE DETERMINATION OF THE SUITABILITY OF CRYSTALS FOR OPTICAL COMPONENTS EXPOSED TO HIGH ENERGY DENSITIES, CRYSTALS GRADED IN THIS WAY AND USES THEREOF - A method is described for quantitative determination of suitability of an optical material, especially alkali halide and alkaline earth halide single crystals, for optical components exposed to high energy densities, especially of pulsed laser light at wavelengths under 250 nm. In this procedure radiation-dependent transmission of the optical material is determined at ultraviolet wavelengths by fluorescence measurements for fluorescence induced by ultraviolet radiation at these ultraviolet wavelengths. This is accomplished by a method including determining an induced fluorescence maximum of a non-linear absorption process, measuring a slope (|dT/dH|) of a functional relationship representing the dependence of the radiation-dependent transmission on fluence (H) for the induced fluorescence and determining radiation-dependent transmissions from this slope for particular fluence values. | 01-07-2010 |
20100001209 | Halide-based scintillator nanomaterial - Scintillator material comprising nanoparticles (nanocrystals) comprising lead (Pb), iodine (I), and optionally one or both of oxygen (O) and hydrogen (H) wherein the nanoparticles exhibit room-temperature scintillation under gamma irradiation. The scintillator nanoparticles can comprise Pb | 01-07-2010 |
20100006772 | METHOD AND APPARATUS FOR HIGH-RESOLUTION OPTICAL SCANNING OF A SAMPLE - A method and an apparatus are suggested for high-resolution optical scanning, particularly in a laser scanning fluorescence microscope. A sample to be scanned comprises a first and a second substance that are switchable into a first and second energy state. In the scanning process, excitation, de-excitation and detection for the first substance is carried out at a different point in time than for the second substance. This achieves a high spatial resolution beyond the diffraction limit while at the same time a high level of information is provided with physically simple and economical means. | 01-14-2010 |
20100006773 | Method and apparatus for measuring the phase shift induced in a light signal by a sample - A first light source emits a light signal along a measurement optical path that includes a sample and a second light source emits a light signal along a dummy measurement optical path. A measurement circuit receives the light signals and provides outputs separated in time which are indicative of the phase of the respective light signals. A phase shift is induced in light in the measurement optical path by the sample. A reference circuit receives a signal indicative of the phase of the light signals emitted by the first and second light sources. Circuitry compares the phases of light output from the two circuits to provide output indicative of a first measured phase difference during operation of the first light source. Correction is applied to this measurement by taking a similar phase difference measurement during operation of the second light source and comparing the two phase differences. | 01-14-2010 |
20100006774 | DETECTION METHOD, DETECTION APPARATUS, AND SAMPLE CELL AND KIT FOR DETECTION - A sensor chip including a sensor portion that has at least a metal layer deposited on a surface of a dielectric plate is used. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a liquid sample binds onto the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent label in the fluorescent-label binding substance. An electrified fluorescent substance containing a plurality of fluorescent dye molecules enclosed by a material that transmits fluorescence output from the plurality of fluorescent dye molecules is used as the fluorescent label. The electrified fluorescent substance is attracted to the sensor portion by applying voltage to the liquid sample in a state in which the fluorescent-label binding substance has bound to the sensor portion. In this state, the amount of the detection target substance is detected. | 01-14-2010 |
20100012853 | METHOD FOR PRE-IDENTIFICATION OF SPECTRAL OVERLAPS WITHIN FLUORESCENT DYE AND DETECTOR COMBINATIONS USED IN FLOW CYTOMETRY - This invention relates to the field of flow cytometry. It provides methods for identifying important dye-detector spectral overlaps for use in designing flow cytometry experiments. It further provides methods for quantifying the impact of spectral overlaps on dye selection and detector selection, the methods including the steps of: a) obtaining spectra of a dye; b) obtaining a laser configuration and an optical filter configuration of a detector; c) obtaining a spectrum yield value; and d) ranking the spectrum yield value. | 01-21-2010 |
20100019169 | REMOTE LASER INTERROGATION OF THREAT CLOUDS AND SURFACES - This invention concerns the remote detection of threat clouds and evaluation of their components. Also included is the remote detection and evaluation of contamination on surfaces or in air streams. To enable this detection, fluorophores that are attached to POSS are used with two-photon LIF imaging that provides enhanced background-free imaging even in the presence of scattering particles such as dust, sand and water droplets. | 01-28-2010 |
20100019170 | THREE-DIMENSIONAL IMAGING USING A FLUORESCENT MEDIUM - The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth. | 01-28-2010 |
20100032584 | TIIME GATED FLUORESCENT FLOW CYTOMETER - An apparatus ( | 02-11-2010 |
20100044584 | CARBON NANOTUBE CONTAINING MATERIALS AND ARTICLES CONTAINING SUCH MATERIALS FOR ALTERING ELECTROMAGNETIC RADIATION - Disclosed herein is a material for altering electromagnetic radiation incident on the material. The material disclosed herein comprises carbon nanotubes having a length (L) that meets the following formula (1): | 02-25-2010 |
20100044585 | BIOSENSOR USING WIRE-GRIDS FOR INCREASING CAVITY ENERGY - The invention discloses a luminescence sensor ( | 02-25-2010 |
20100044586 | FAST THERMO-OPTICAL PARTICLE CHARACTERISATION - The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius). | 02-25-2010 |
20100051826 | Fluorescent Xanthenes and White Light Fluorophores - Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges. | 03-04-2010 |
20100059690 | FLUOROSCOPIC DEVICE AND FLUOROSCOPIC METHOD - A lesion can be made distinctive in an acquired fluorescence image so as to allow for accurate diagnosis. There is provided a fluoroscopic device ( | 03-11-2010 |
20100065756 | Nano-particle/quantum dot based optical diode - A particle based optical diode having at least two cavities or at least two regions of a single cavity, wherein the regions contain different types of particles. | 03-18-2010 |
20100072396 | CONCURRENT MONITORING OF A PLURALITY OF SAMPLES BY AN ARRAY OF BIOSENSING ELEMENTS - A system and method are presented for monitoring detectable responses from multiple biosensing elements while in contact with multiple samples located in an array. The system ( | 03-25-2010 |
20100072397 | SUB WAVELENGTH APERTURE - There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture. | 03-25-2010 |
20100078576 | Systems and Methods for Optical Imaging Using Early Arriving Photons - Optical imaging systems and methods use early photons in order to generate processed fluorescent light images of fluorescent material on or within a tissue. The early photons are generated in accordance with a pulsed light source and an early-photon light receiver. The processed fluorescent light images tend to have improved resolution and imaging accuracy compared with fluorescent light images generated with photons beyond the early photons portions. | 04-01-2010 |
20100084571 | RADIOISOTOPE POWERED LIGHT MODULATING COMMUNICATION DEVICES - The present disclosure relates to a light modulating communication device comprising a housing comprising at least one inner chamber, and an opening, at least one quantum dot positioned inside the at least one inner chamber, a high-energy emitting source positioned within the at least one inner chamber, a modulator positioned proximal to the opening of the housing, and optionally, at least one reflector positioned within the at least one inner chamber. The present disclosure also relates to a method comprising providing at least one quantum dot, contacting the at least one quantum dot with high-energy particles such that light is produced from the at least one quantum dot, and modulating the light produced from the at least one quantum dot. | 04-08-2010 |
20100090127 | TIME RESOLVED FLUORESCENT IMAGING SYSTEM - This invention provides a system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time. | 04-15-2010 |
20100096561 | METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION - A radiation detection system ( | 04-22-2010 |
20100096562 | WIREGRID WAVEGUIDE - There is provided a wave guide comprising: a wave guiding medium, having an index of refraction and provided between first and second wave propagating planar structures at least said first planar structure comprises a plurality of slitted-apertures defining a length axis of the first reflective structure; the slitted apertures constructed and arranged to reflect a R-polarized component of said radiation oriented parallel to said length axis; and wherein said first planar structure is arranged between said wave guiding medium and an adjacent medium having an index of refraction equal or larger than the wave guiding medium. In one aspect of the invention, a waveguide is proposed to limit an excitation region wherein luminophores are excited; substantially independent from the surrounding media of the waveguide. Preferentially, the waveguide is used in a luminescence sensor. | 04-22-2010 |
20100096563 | LUMINESCENCE SENSOR - The present invention provides a luminescence sensor ( | 04-22-2010 |
20100102249 | METHOD OF LUMINESCENT SOLID STATE DOSIMETRY OF MIXED RADIATIONS - A method of determining the doses of neutrons, gamma and X-ray photons, beta, alpha and other ionizing radiations using a method of image processing in spatial and frequency domain that produces parameters that are related to the radiation dose absorbed in a luminescent material. Portions of the luminescent material may be covered by different converters to allow for doses of different radiations to be discriminated. | 04-29-2010 |
20100102250 | PHOSPHOR BASED AUTHENTICATION SYSTEM - A phosphor (photo-luminescent) material based authentication system in which a blend (mixture) of at least two, preferably three or more, phosphor materials are used as a photo-luminescent security marking which is applied to or incorporated within an article/document to be authenticated. Preferably, the phosphor materials are each excitable by “eye safe” excitation radiation comprising visible light of wavelength 380 nm to 780 nm. Moreover, when excited the security marking preferably also emits visible light thereby minimizing any risk of damage to an operator's eye in the event of accidental exposure to the excitation radiation and/or light generated by the photo-luminescent marking. The authenticity of the article/document can be authenticated by verification of the composition of the phosphor by exciting the marking and comparing one or more selected parameters of light emitted by the security marking with corresponding parameters of the characteristic emission spectrum of the authentic phosphor blend. | 04-29-2010 |
20100108910 | PATHOGEN AND PARTICLE DETECTOR SYSTEM AND METHOD - The system includes an excitation source for providing a beam of electromagnetic radiation having a source wavelength. A first wavelength selective device is positioned to be impinged by the beam of electromagnetic radiation. The first wavelength selective device is constructed to transmit at least a portion of any radiation having the source wavelength and to reflect radiation of other wavelengths. A medium containing particles is positioned to be impinged by the beam of electromagnetic radiation. At least a portion of the beam of electromagnetic radiation becomes scattered within the medium, the scattered electromagnetic radiation including forward scattered electromagnetic radiation and backward scattered electromagnetic radiation. An optical detector is positioned to receive backward and/or forward scattered electromagnetic radiation. | 05-06-2010 |
20100117003 | METHOD FOR THE QUANTITATIVE DETERMINATION OF THE CONCENTRATION OF FLUOROPHORES OF A SUBSTANCE IN A SAMPLE AND APPARATUS FOR CARRYING OUT THE SAME - The invention concerns a method and an apparatus for the quantitative determination of the concentration of fluorophores of at least one substance in a sample. A constant portion of the reference light of a reference light wave length (λr) emitted by a reference light source ( | 05-13-2010 |
20100123088 | ENHANCED INSTRUMENTATION AND METHOD FOR OPTICAL MEASUREMENT OF SAMPLES - The present invention relates generally to the field of biochemical laboratory instrumentation for different applications of measuring properties of samples on e.g. microtitration plates and corresponding sample supports. The object of the invention is achieved by providing an optical measurement instrumentation wherein a sample ( | 05-20-2010 |
20100140501 | FLUORESCENCE NOTCH CODING AND AUTHENTICATION - Systems and methods for document and product authentication using a variety of absorption and emission signatures are disclosed. Emission signatures in the form of florescent or phosphorescent coatings, inks and substrates are used for authentication and protection of items such as documents, currency, and secondary packaging for tobacco, luxury goods and pharmaceuticals. Spectrally overlapping absorption and emission materials are combined to provide a unique spectral fingerprint detectable by a scanner. | 06-10-2010 |
20100140502 | OXYGEN SENSITIVE MATERIAL, SENSORS, SENSOR SYSTEMS WITH IMPROVED PHOTOSTABILITY - An oxygen sensitive polymeric material with enhanced photostability, comprising an oxygen sensitive indicator and photostabilizer incorporated into an oxygen permeable polymeric material is provided. The oxygen sensitive indicator can be, but is not limited to, [Ru(L1)(L2)(L3)] | 06-10-2010 |
20100140503 | APPARATUS AND METHOD FOR READING FLUORESCENCE - It is an objection of the present invention to provide a fluorescence reading apparatus in view of the influence of fluorescence derived from a fluorescence substance that is not involved with an interaction between a probe substance and a target substance. | 06-10-2010 |
20100140504 | FLUORESCENCE MEASUREMENT - Methods and apparatus for measuring fluorescence, are described. The method includes measuring at least one profile of at least a portion of a surface of a sample, the surface extending substantially transverse an axis, and illuminating the portion of the sample surface with radiation for stimulating fluorescence. The intensity of the radiation varies with position along the axis. Values indicative of the spatial intensity distribution of fluorescence emitted from said portion of the sample surface are measured. The measured values of fluorescence are modified to take account of the spatial variation in intensity of radiation incident upon the surface by utilising the measured profile. | 06-10-2010 |
20100140505 | CAPILLARY ELECTROPHORESIS FLUORESCENT DETECTION SYSTEM - The invention includes a high sensitivity and high throughput capillary electrophoresis multiwavelength florescence detection system. The fluorescent detection system is configured to illuminate a relatively large volume of a single capillary or a plurality of capillaries, with a pixelated detection system capable of imaging an area of each capillary that differentiates the capillary walls, the space between the capillaries, and the internal liquid volume within the capillary. Only the desired pixels or image area are used for processing and generating an output signal. | 06-10-2010 |
20100140506 | METHOD OF DETERMINING A MEASUREMENT VALUE ON THE BASIS OF SINGLE MOLECULE EVENTS - A method of determining a measurement value on the basis of a plurality of single molecule events of marker molecules in a sample comprises the steps of selecting the marker molecules from a group of marker molecules which are transferable between a measurable state in which a measurement signal necessary for determining the at least one measurement value is obtainable from the marker molecules and a non-measurable state, of providing the marker molecules in the sample at such an absolute concentration that the at least one measurement value is not determinable, if all marker molecules are in their measurable state, and adjusting a measurement concentration of the marker molecules in the measurable state by means of applying the physical signal to the sample at such an intensity that the at least one measurement value is determinable within a defined measurement area of the sample. | 06-10-2010 |
20100148091 | METHOD AND SYSTEM FOR RAPID PHASE LUMINESCENSE SPECTROSCOPY ANALYSIS - A system for use in analyzing a pharmaceutical composition having multiple constituents comprising a luminescence sensor, the sensor being adapted to direct a plurality of radiation pulses to the pharmaceutical composition and detect luminescence emitted from each composition constituent as a function of time, the sensor being further adapted to provide at least one luminescence signal corresponding to the detected luminescence of each constituent, and control means in communication with the sensor for controlling the sensor and analyzing the luminescence signal. | 06-17-2010 |
20100148092 | MICROARRAY READER BASED ON EVANESCENT WAVE DETECTION AND METHOD OF READING A MICROARRAY - A microarray reader ( | 06-17-2010 |
20100155622 | METHOD AND DEVICE FOR LOCALISING FLUOROPHORES OR ABSORBERS IN A SURROUNDING MEDIUM - The invention relates to a method of localising a fluorophore ( | 06-24-2010 |
20100163747 | VALUABLE DOCUMENT - The invention relates to a printed value document having at least one luminescent substance. | 07-01-2010 |
20100163748 | DUAL DETECTOR CAPILLARY WAVEGUIDE BIOSENSOR AND METHOD FOR USE THEREOF - A method for fluorescence detection that provides control of experimental and molecular factors and reliably predicts of concentration from fluorescence intensity measurements utilizing capillary-based flow sensors utilizing a dual detector approach to provide instantaneous normalization of the fluorescent intensity by the Rayleigh scattered intensity measured from the same sensing volume, insensitive to various experimental parameters for prediction of absolute concentrations of fluorescent solutes. | 07-01-2010 |
20100171043 | SINGLE ELEMENT SENSOR WITH MULTIPLE OUTPUTS - An analyte sensor is described. The sensor employs a single sensor element which provides a plurality of phase outputs in response to excitation by a modulated excitation source. The plurality of phase outputs may be analysed to provide information on the presence of one or more analytes. | 07-08-2010 |
20100176307 | STED-Fluorescent Light Microscopy with Two-Photon Excitation - A method of high spatial resolution imaging a structure in a sample comprises: marking the structure with molecules of a fluorescent dye; selecting a first wavelength for excitation light which excites the molecules of the fluorescent dye via a multi photon process for spontaneous emission of fluorescent light; focussing pulses of the excitation light into the sample to excite those molecules of the fluorescent dye present in a focal area of the focussed excitation light; selecting a second wavelength shorter than the first wavelength for de-excitation light which de-excites excited molecules of the fluorescent dye prior to their spontaneous emission; during a plurality of the pulses of the excitation light, continuously directing the de-excitation light onto the sample to de-excite excited molecules of the fluorescent dye, which are located outside an measurement area which is a fraction of the focal area; and recording the fluorescent light spontaneously emitted by the molecules of the fluorescent dye in the sample. | 07-15-2010 |
20100181496 | IN-SITU PLANT ANALYSIS APPARATUS, METHOD FOR TRACKING THE STATE OR EVOLUTION OF A CULTURE AND METHOD FOR MANAGING VEGETABLE PROCESSING - A device for analyzing plants, by luminous excitation and fluorescence measurement, can be used on site without preparation of the plants. The device evaluates the content of a compound in the skin or epidermis of a plant. The geometry of the device is characterized by a direction of the excitation light rays and a direction of the fluorescence light rays which are non-collinear with each other. The device includes several sets of emitters of different wavelengths, each including several emitters, and makes it possible to measure a plurality of excitation-fluorescence combinations. A method for evaluating and monitoring the development and maturity of a crop, as well as a method for monitoring and controlling plant treatment are also described. | 07-22-2010 |
20100181497 | OPTICAL MICROSCOPY WITH PHOTOTRANSFORMABLE OPTICAL LABELS - An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and excited phototransformable optical labels (“PTOLs”) in a sample onto the position sensitive-detector. A first light source provides activation radiation to the sample to activate a subset of the PTOLs that are distributed in the sample with a density greater than an inverse of the diffraction-limited resolution volume of the optical system. A second light source provides excitation radiation to the sample to excite a portion of the PTOLs in the subset of the PTOLs. A controller controls one both of the activation radiation and the excitation radiation provided to the sample such that a density of PTOLs in the portion of the PTOLs is less than the inverse of the diffraction-limited resolution volume. | 07-22-2010 |
20100187439 | Fluorescent Monitoring Of Microcapsule Oxidation - The present disclosure relates to microcapsules that include a shell material and a core material. The core material of the microcapsules contains an environmentally sensitive luminescent colorant which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics capable of changing upon exposure to a given environment, and a luminescent standard which exhibits characteristics of an emitted wavelength bandwidth, a peak intensity for emission and a time for luminescence decay, one or more of the characteristics do not change upon exposure to said given environment. | 07-29-2010 |
20100187440 | LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs. | 07-29-2010 |
20100187441 | TRANSILLUMINATOR ADAPTOR FOR CONVERSION OF ULTRAVIOLET RADIATION TO VISIBLE LIGHT - An adaptor is designed as an accessory to an ultraviolet transilluminator for the excitation of fluorescent molecules or labels in a planar array of biochemical samples such as a two-dimensional electrophoresis gel to enable the emissions resulting from the excitation to be detected and quantified. The adaptor is constructed to overlay the transilluminator and contains both a fluorescent dye that upon excitation by ultraviolet light emits light in the visible spectrum, and a conditioning substance that selects a portion of the wavelength band of the visible light produced by the fluorescent dye. The adaptor converts the ultraviolet light from the transilluminator to visible light while limiting the emissions reaching the detector to those that emanate from the sample. By the use of this adaptor, the transilluminator is adapted for use with samples labeled with dyes that are excitable by visible light and avoids exposure of the samples and the user to ultraviolet light. | 07-29-2010 |
20100193703 | FRET DETECTION METHOD AND DEVICE - When FRET (Fluorescence Resonance Energy Transfer) detection of a large number of samples is performed in a short time for a sample consisting of a donor molecule and an acceptor molecule, the donor molecule is irradiated at first with first laser light used for exciting a donor molecule subjected to intensity modulation at a frequency of f+Δf, the accepter molecule is irradiated with second laser light used for exciting an acceptor molecule subjected to intensity modulation at a frequency of f, and fluorescence emitted from the accepter molecule is received. From a fluorescence signal thus received, a first signal component of fluorescence emitted from the accepter molecule through FRET, and a second signal component of fluorescence emitted from an accepter molecule excited through irradiation with the second laser light are extracted. Phase lags of the first and second signal components thus extracted are then calculated and the presence of generation of FRET is judged based on these phase lags. | 08-05-2010 |
20100193704 | FLUORESCENCE EXCITATION AND DETECTION SYSTEM AND METHOD - An excitation and detection system is provided for separately detecting different wavelengths of emission light emitted from a sample. The system comprises an excitation assembly to excite a sample and a detection assembly to receive fluorescence emitted from the sample. The detection assembly includes a multi-band dichroic member and at least first and second detection cameras. The multi-band dichroic member has a transmission/reflection characteristic with at least two transmissive regions separated from each other along the wavelength spectrum and with at least one reflective region separated from the transmissive regions along the wavelength spectrum. The dichroic member transmits fluorescence that aligns with the at least two transmissive regions to the first detection camera. The dichroic member reflects fluorescence that aligns with the reflective region to the second detection camera. The dichroic member multiplexes the detection of fluorescent signals without the use of a filter wheel in the detection assembly. The components of the detection assembly remain stationary throughout imaging of multiple colors, for example therefore allowing the use of two detectors to record images of three or more colors without the need for filter wheels or other moving components. | 08-05-2010 |
20100193705 | APPARATUS AND METHOD FOR INTERLEAVING DETECTION OF FLUORESCENCE AND LUMINESCENCE - An apparatus is provided that is capable of interleaving detection of fluorescence and luminescence signals emitted from a plurality of samples. The apparatus is suitable for analysis of samples containing single cells or tissues up to and including living organisms. It contains an optical assembly or “sandwich” for producing a spectrally pure and spatially disperse light source for illuminating the sample. The invention also provides a plurality of optical sandwiches that can be variously geometrically arranged and their intensities programmed to create spatially uniform illumination over a large sample. The invention further provides an apparatus having at least one of the optical sandwich and a detector system capable of interleaving detection of fluorescent and luminescent signals when a suitable sample is illuminated by the light source of the optical sandwich. Methods for preparing samples and using the sandwiches, arrays and apparatus, are further provided by this invention. A method for interleaving detection of fluorescent and luminescent signals emitted from a plurality of samples is disclosed. | 08-05-2010 |
20100207036 | OPTICAL IMAGING DEVICE - The invention concerns an optical imaging device for a human or animal body, including: an optical sensing system, a drive system of at least one light collector from the optical sensing system, permitting modification of at least the position and/or direction, and a control system from the drive system, arranged so as to lead the light collector from the optical sensing system to at least one observation situation of at least one chosen region of the body to be examined, based on data concerning its topology. | 08-19-2010 |
20100213388 | METHOD AND DEVICE FOR DETECTING DEGRADATION IN THE QUALITY OF A BRAKE - A method and a device for detecting degradation in the quality of a brake fluid are disclosed. The brake fluid comprises a luminescent dye, wherein there is a change in luminescence emitted by the dye in response to a change in water content of the brake fluid. | 08-26-2010 |
20100213389 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR LOCALIZING PHOTONS AND A LIGHT SOURCE EMITTING THE PHOTONS - Localization methods and methods for localizing a light source using multivariate statistical analysis. In particular, a multi-variate distribution, such as a multi-variate normal distribution, may be used to localize photons originating from a light source and, in particular, may be used to analyze photon position maps acquired by Photon Event Distribution Sampling (PEDS). The multi-variate distribution assigned to each of the photons in the photon position map may be summed to predict a most probable location for the light source. | 08-26-2010 |
20100219353 | APPARATUS AND METHOD OF ACQUIRING IMAGES OF A SAMPLE OF BIOLOGICAL ORIGIN - A novel apparatus and a novel method of imaging a luminescence phenomenon of a sample of biological origin using an optical image formation device are provided. In the inventive method and apparatus, an illumination image acquired by illuminating the sample and a luminescence image acquired with the light emitted by a luminescence phenomenon of a cell in the sample without illuminating it are superposed to generate a superposition image. In the superposition image, an analysis region is determined. Thereby, even when the light detected in a luminescence observation is feeble, a luminescent cell and/or a luminescent site in a cell in a sample can be specified. | 09-02-2010 |
20100224796 | Imaging System Using Dynamic Speckle Illumination - A versatile, imaging system that uses dynamic speckle illumination (DSI) is disclosed. The DSI microscope includes at least one light source for producing light to illuminate a target object in an object plane; an image recording device for recording a sequence of images of the target object; imaging optics for transmitting signal light from the target object as the sequence of images from the target object to the image recording device; and a dynamic speckle generating system for illuminating the target object with dynamic speckle. | 09-09-2010 |
20100224797 | Method And Device For 3D Reconstruction Of The Distribution Of Fluorescent Elements - A device and method for processing fluorescence signals emitted after excitation by radiation coming from a radiation source, by at least one fluorophore with a lifetime τ in a surrounding medium, which signals are detected by detection means, and which method includes the calculation, on the basis of detected fluorescence signals, of values of a variable, independent of τ, of the position or the distribution of fluorophore in said medium. | 09-09-2010 |
20100230610 | INTEGRATED DEVICE HAVING AN ARRAY OF PHOTODETECTORS AND AN ARRAY OF SAMPLE SITES - An integrated device for detecting emissions from a sample ( | 09-16-2010 |
20100230611 | Lighting system, mehtod of lighting, optical detector, and method of optical detection - There is provided a lighting system having a high spatial resolution appropriate to a high-frequency component by evanescent waves in a negative refraction lens. The lighting system includes a light emitter thin film ( | 09-16-2010 |
20100230612 | Method of analysis of samples by determination of a function of specific brightness - A method for characterizing samples having units, by monitoring fluctuating intensities of radiation emitted, scattered and/or reflected by said units in at least one measurement volume, the monitoring being performed by at least one detection means, said method comprising the steps of:
| 09-16-2010 |
20100230613 | MICROFLUIDIC DEVICES AND METHODS - Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices. | 09-16-2010 |
20100230614 | System And Method For Time-Division Multiplexed Optical Sensing Of Biosensors - A measurement system for use with fluorescent chemosensors has multiple stimulus light sources each coupled to at least one sensor. Multiple sensors each receiving light from a different light source connect to each of one or more photodetectors. A processing device drives the light sources in a time-division multiplexed manner, and reads the photodetector at an appropriate time for each sensor. The processing device calibrates the sensor readings and provides them in a way that is identified to the associated sensor. | 09-16-2010 |
20100237255 | OPTICAL FIBER SENSOR - A sensor based on optical fiber technology is described. The sensor includes an elongate core for propagating light having an excitation wavelength; an interaction region that includes a fluorescent material for excitation by the propagated light to produce fluorescent light; and an interface region defining a boundary between the elongate core and the interaction region. The elongate core of the sensor is adapted to increase an intensity of the propagated light at the interface region to increase the amount of captured fluorescent light in the elongate core. | 09-23-2010 |
20100243916 | MODULAR OPTICAL DIAGNOSTIC PLATFORM FOR CHEMICAL AND BIOLOGICAL TARGET DIAGNOSIS AND DETECTION - A modular system for optical diagnosis of a sample includes a portable optical probe, a light source, a filter, and a gain detector. A first optical element releasably, optically couples the optical probe to the light source. A second optical element releasably, optically couples the optical probe to the filter and a third optical element releasably, optically couples the filter to the gain detector. The optical probe receives an optical signal from the light source via the first optical element and directs the optical signal onto the sample, thereby inducing fluorescence emission from the sample. The optical probe receives the fluorescence emission from the sample and transmits to the filter via the second optical element. The filter transmits the fluorescence emission to the gain detector via the third optical element. The optical head includes a beam splitter which reflects the fluorescence emission from the sample to the filter. | 09-30-2010 |
20100252749 | WIPER BLADE - The invention describes a wiper blade, in particular for windscreen wipers, which is at least partly provided with at least one coating, wherein the coating contains at least one indicator component for determining the layer thickness of the coating. The invention also describes a method for determining the layer thickness of a coasting of a wiper blade. | 10-07-2010 |
20100252750 | SYSTEMS AND METHODS FOR STIMULATED EMISSION IMAGING - A microscopy imaging system is disclosed that includes a light source system, focusing optics, an optical detector and a processor. The light source system is for providing an excitation beam at a center optical frequency ω | 10-07-2010 |
20100252751 | MICROELECTRONIC OPIACAL EVANESCENT FIELD SENSOR - There is provided a microelectronic sensor device ( | 10-07-2010 |
20100258740 | FLUORESCENCE DETECTION METHOD - A fluorescence detection method allows fluorescence intensity detection from a fluorescently-labeled biological sample with high accuracy in shorter time, even when a fluorescence intensity from a microchip itself acting as background. A fluorescence intensity from an equivalent microchip, which is equivalent to a microchip with the fluorescently-labeled biological sample, is detected for a period from the start of application of excitation light until the intensity sufficiently attenuates, and a temporal change of the intensity is stored. The light is applied to the microchip and the sample is fed before the fluorescence intensity from the microchip sufficiently attenuates to detect the fluorescence intensity for a period from the start of application of the light to a point after the sample is fed. Values of the temporal change are subtracted from the intensity detected from the microchip with the sample to detect an intensity of fluorescence emitted from the sample. | 10-14-2010 |
20100258741 | METHOD AND DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM - The invention relates to a method and a device ( | 10-14-2010 |
20100258742 | DYE COMPOSITION FOR LIQUID TRANSFER CONTROL - The present invention provides kits and methods for composition ratio control based on dyes that are designed to enable energy transfer between each other. In more detail, with the method of the present invention it is possible to verify the mixing ratio of a first component comprising a first dye with a second component comprising a second dye. | 10-14-2010 |
20100264331 | METHOD FOR ASSAYING NUCLEIC ACIDS BY FLUORESCENCE - The invention relates to a method for determining the amount of nucleic acid present in a sample, wherein:—a fluorophore is added to the sample,—fluorescence intensities emitted by the fluorophore at least two emission wavelengths in response to light stimulations at least two excitation wavelengths respectively are measured, and—the amount of nucleic acid present in the sample is deduced from the measured fluorescence intensities. | 10-21-2010 |
20100264332 | APPARATUS AND METHOD FOR DETECTION AND MEASUREMENT OF TARGET COMPOUNDS SUCH AS A FOOD TOXIN - A method for the detection or determination of a target comprising a plurality of target compounds, or derivatised target compounds, said method comprising: immobilising said target on a carrier, directing radiation at said target, said radiation being selected to cause said target to emit a relevant radiation, detecting said relevant radiation emitted by said target, and analysing said detected radiation to identify and/or quantify the plurality of target compounds in said target. | 10-21-2010 |
20100264333 | Gas Sensing Device - The present invention relates to a gas sensing device comprising a nanoparticle layer ( | 10-21-2010 |
20100264334 | EXCITATION-INTENSITY-DEPENDENT, COLOR-TUNABLE, DUAL EMITTING NANOCRYSTALS - An embodiment of the invention is a device for photo-stimulated color emission having at least one plurally doped semiconducting nanoparticle comprising at least one semiconducting material and a plurality of at least one dopant coupled with an irradiation source such that the plurally doped semiconducting nanoparticle emit electromagnetic radiation at two or more wavelengths where the intensities of the emissions depend on the intensity of the irradiation. In an embodiment of the invention, the plurally doped semiconducting nanoparticle can be a doped core/shell nanoparticle where the plurality of dopants can reside in exclusively the core, exclusively the shell, or in both the core and shell. | 10-21-2010 |
20100270479 | NON-IMAGING, WEAKLY FOCUSED FLUORESCENCE EMISSION APPARATUS AND METHOD - Apparatus and methods relating to non-imaging, multiphoton fluorescence and optical second harmonic generation (SHG) (and higher harmonic generation) emission and detection. A weakly focused excitation beam is used to generate fluorescence emission in a volume of between about 0.1 cm | 10-28-2010 |
20100276608 | High-Resolution Microscope Using Optical Amplification - Systems and methods that enhance the resolution of a microscope in all three spatial dimensions. A microscope system is provided that typically includes a first objective lens ( | 11-04-2010 |
20100282982 | DEVICE FOR MEASURING THE FLUORESCENCE OF A MEDIUM - A device for measuring the fluorescence of a medium having a radiation source, an emission-receiving element and an optical imaging element arranged on the sensor side of the optical imaging element, and a scattering-receiving element arranged on the sensor side of the optical imaging element and in which the radiation source, the imaging element and the emission-receiving element are aligned and configured relative to one another so that the medium present on the medium side of the imaging element can be illuminated by radiation from the radiation source, and the emission intensity of the medium radiation emitted by the medium based on fluorescence can be detected with the emission-receiving element. To provide a device for measuring the fluorescence of a medium which has an increased reliability in measuring the fluorescence, temperature compensation is performed relative to the temperature of the medium and/or at least one of the receiving elements. | 11-11-2010 |
20100288943 | DEGRADABLE TAGGANT AND METHOD OF MAKING AND USING THEREOF - The present invention is a low-cost, easily deployed, degradable taggant that can be dispersed over a wide area to serve as a witness to activity in the area and for queuing of other sensors. The taggant enables nearly real-time change detection within the treated area using one or more simple optical sensing techniques. | 11-18-2010 |
20100294951 | Sensitive gas-phase flourimeter at ambient pressure for nitrogen dioxide - An instrument detects an amount of a component of a sample gas by passing an excitation light through the sample gas at atmospheric pressure to produce fluorescence light from the component. The fluorescence light is discriminated using a sequence of multiple long pass interference filters to filter out the excitation light. The discriminated fluorescence light is then detected to produce a signal representative of the amount of the component in the sample gas. Preferably, the excitation light is continuously passed through the sample gas. In one embodiment, the gas flows through a cell having a parabolic reflector as an interior surface and a source of the excitation light at a focus of the parabolic reflector. In other embodiments, multiple components are detected in parallel using multiple sample cells and a fiber optic multiplexer to sequentially filter and detect the fluorescence light from each of the multiple sample cells. | 11-25-2010 |
20100301230 | METHOD AND APPARATUS FOR ULTRAVIOLET SCAN PLANNING - The invention provides method for locating one or more substantially circular-shaped tissue sample positioned on a solid support. The method involves the steps of transmitting light of a preselected wavelength onto a tissue sample, wherein the light induces the tissue sample to autofluoresce, identifying the center location of the tissue sample using the autofluoresced light, correlating the coordinates of the center location of the tissue sample on the solid support using an x, y-coordinate system, and mapping the coordinates of the tissue sample on the solid support to differentiate tissue sample containing regions from blank regions on the solid support. In a second aspect, the invention provides an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support. | 12-02-2010 |
20100301231 | APPARATUS, METHOD AND COMPUTER PROGRAM FOR FLUORESCENCE CORRELATION SPECTROSCOPY - There are provided an apparatus, a method and a computer program for fluorescence correlation spectroscopy (FCS), which can reduce the number of times of fluorescence measurements of control samples as few as possible for a measurement by FCS in detecting existence ratios of the respective components contained in a sample. In the inventive apparatus, method and computer program for detecting an existence ratio of each of components with a fluorescent label contained in a solution sample by FCS, using a value of a ratio of a translational diffusion time of each of the components based upon the knowledge that a ratio of a translational diffusion time of each of the components is conservative under different measurement conditions etc. | 12-02-2010 |
20100301232 | LASER SCANNER APPARATUS FOR FLUORESCENCE MEASUREMENTS - The invention relates to a laser scanner apparatus ( | 12-02-2010 |
20100314555 | OPTICAL MEASUREMENT APPARATUS, FLOW SITE METER AND OPTICAL MEASUREMENT METHOD - Disclosed herein is an optical measurement apparatus including at least: a flow channel through which samples flow; a first light radiation section; a first opto-electrical conversion section; a first analog-to-digital conversion section; a second light radiation section; a second light detection section; a second opto-electrical conversion section; an amplification section; and a second analog-to-digital conversion section. | 12-16-2010 |
20100314556 | 1,8-NAPHTHALIMIDE DERIVATIVES AS SCINTILLATION AGENTS, IN PARTICULAR FOR DISCRIMINATING BETWEEN FAST NEUTRONS AND GAMMA RAYS - The invention relates to the use of 1,8-naphthalimide derivatives and of their salts as scintillation agents and more specifically as agents for discriminating between fast neutrons and gamma rays. | 12-16-2010 |
20100314557 | FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - In a fluorescence detection device and a fluorescence detection method, forward-scattered light which is scattered from a measurement object irradiated with a laser beam is received and detection signals for informing the measurement object passing through the measurement point and for identifying a focus position of the forward-scattered light are produced. While, fluorescence emitted by the measurement object is received through a collecting lens and a light-reception signal of the fluorescence is outputted. The fluorescence intensity level is outputted based on the outputted light-reception signal and the produced detection signals. A focus position of the forward-scattered light is identified from the produced detection signals and the light reception-signal is corrected using a correction coefficient corresponding to the identified focus position. | 12-16-2010 |
20100320398 | FLUORESCENCE DETECTING METHOD AND FLUORESCENCE DETECTING DEVICE - Provided are a fluorescence detecting method and a fluorescence detecting device for calculating the fluorescence relaxation time constant more accurately than in the prior art when fluorescence emitted from an analyte is detected by applying laser beam. When the analyte passes the position irradiated with laser beam modulated in intensity by a modulation signal of a predetermined frequency, a first fluorescence signal of fluorescence received by a light-receiving means is collected. A second fluorescence signal of the fluorescence received by the light-receiving means is collected in a state in which the analyte is not in the position irradiated with the laser beam after the analyte has passed the position irradiated with the laser beam. Phase difference information of a fluorescence signal of the fluorescence emitted from the analyte with respect to the modulation signal of the laser beam is obtained by using the collected first fluorescence signal and second fluorescence signal, and the fluorescence relaxation time constant of the fluorescence emitted from the analyte is obtained from the obtained phase difference information of the fluorescence signal of the fluorescence emitted from the analyte. | 12-23-2010 |
20100327184 | FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - A fluorescence detection device includes a flow cell body including a flow channel through which a measurement object flows, a laser light source unit that irradiates, with a laser beam, the measurement object passing through a measurement point in the flow channel, a light-receiving unit that receives fluorescence emitted from the measurement object irradiated with the laser beam and outputs a light-reception signal, and a processing unit that outputs an output value of fluorescence intensity based on the light-reception signal outputted by the light-receiving unit. The flow cell body has a lens provided on a surface thereof so as to traverse an optical path of the laser beam. | 12-30-2010 |
20110006218 | NANODIAMOND COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - Provided are functionalized nanodiamonds. Also provided are methods for fabricating such functionalized nanodiamonds. Also provided are composites including nanodiamonds and polymers. Also provided are methods for fabricating such composites including nanodiamonds and polymers. Also provided are electrospun fibers including nanodiamonds and polymers. Also provided are methods for fabricating such electrospun fibers including nanodiamonds and polymers. | 01-13-2011 |
20110006219 | DATA ACQUISITION METHOD USING A LASER SCANNER - The invention relates to a data acquisition method using a laser scanner for the pixel-precise imaging of fluorescent samples which are on object carriers and have been treated with fluorescent dyes. Such a laser scanner comprises a sample table; at least one laser and a first optical system for providing at least one laser beam for exciting the fluorescent samples; a scanner head ( | 01-13-2011 |
20110006220 | FLUORESCENT-IMAGE ACQUISITION APPARATUS, FLUORESCENT-IMAGE ACQUISITION METHOD AND FLUORESCENT-IMAGE ACQUISITION PROGRAM - Disclosed herein is a fluorescent-image acquisition apparatus including an excitement-light source; an objective lens; an image pickup device; focal-point movement control means; and image-pickup control means. | 01-13-2011 |
20110006221 | METHOD FOR EVALUATING OIL-AND-FAT AMOUNT IN SEED AND METHOD FOR SCREENING FOR PLANT EXHIBITING VARIED LEVEL OF OIL-AND-FAT CONTENT - This invention is intended to evaluate the oil-and-fat amount in a seed and genetic changes thereof. A fusion protein of an oil body-specific protein, such as the oleosin-GFP fusion protein, and a fluorescent protein is expressed, and the oil-and-fat amount in a plant seed and changes thereof are evaluated based on the fluorescent intensity in a cotyledon of a fluorescent protein, such as GFP. | 01-13-2011 |
20110012027 | OPTICAL LUMINESCENCE OF FUNCTIONALIZED FULLERENES IN AN OXYGEN FREE ENVIRONMENT - Functionalized fullerenes, when excited at any of a broad range of wavelengths in an oxygen free environment, undergo luminescence. The oxygen sensitive luminescence of functionalized fullerenes is used for numerous applications including oxygen detection; irradiation induced healing of polymeric materials; and phosphors for optical location and display applications. The degradation of the functionalized fullerenes allows for the detection of oxygen by diminished luminescence when the fullerenes are exposed to an irradiation source, such as a laser beam, in the presence of oxygen. The luminescence from a portion of a surface of a material with functionalized fullerenes allows for the location of the surface containing a functionalized fullerene target in the absence of oxygen or to heat the object in the area irradiated that is exposed to oxygen. The localized heating can be used to repair defects to a material containing the functionalized fullerenes. Materials containing functionalized fullerenes can be used as phosphors in display applications. | 01-20-2011 |
20110024648 | LUMINESCENT COMPOUNDS - The subject of the invention is a compound chosen from compounds of formula Y | 02-03-2011 |
20110031410 | METHOD FOR MEASURING FLUORESCENT LIGHT AMOUNT OR LIGHT ABSORPTION AMOUNT AND DEVICE FOR MEASURING THE SAME - An amount of fluorescent light generated from the specimen is quantitatively measured as “a light-amount value per unit area traceable to the national standard” instead of in terms of a ratio (a ratio value) as in the past. A method for measuring a fluorescent light amount, whereby a specimen is irradiated with excitation light, and fluorescent light generated from the specimen is measured by a light-receiving element via a receiving optical system, said method comprising the steps of irradiating the specimen with excitation light having a light-amount value per specified unit area traceable to the national standard, and designated on the surface of the specimen beforehand, causing the light-receiving element to measure the fluorescent light generated from the specimen via the receiving optical system, and computing a fluorescent light-amount as measured by the light-receiving element via the receiving optical system on the basis of an excitation light-amount per the specified unit area, optical coefficients of the receiving optical system, and the acceptance coefficient of the light-receiving element, thereby working out a light amount value per the unit area traceable to the national standard. | 02-10-2011 |
20110031411 | Superresolution in devices with single wavelength illumination - In apparatus for superresolution microscopy or microlithography, wherein a spot in the specimen to be examined or in the microlithographic medium is raised to an excited state by a first pulse of light, and a second pulse of light reduces the excitation in the peripheral parts of the spot to increase the resolution of the instrument, a method whereby the wavelength of the second pulse in the specimen or medium is the same as the wavelength of the first pulse, thereby allowing the cost and complexity of the apparatus to be lowered. | 02-10-2011 |
20110031412 | METHOD OF LUMINESCENT SOLID STATE DOSIMETRY OF MIXED RADIATIONS - A method of determining the doses of neutrons, gamma and X-ray photons, beta, alpha and other ionizing radiations using a method of image processing in spatial and frequency domain that produces parameters that are related to the radiation dose absorbed in a luminescent material. Portions of the luminescent material may be covered by different converters to allow for doses of different radiations to be discriminated. | 02-10-2011 |
20110031413 | METHOD OF LUMINESCENT SOLID STATE DOSIMETRY OF MIXED RADIATIONS - A method of determining the doses of neutrons, gamma and X-ray photons, beta, alpha and other ionizing radiations using a method of image processing in spatial and frequency domain that produces parameters that are related to the radiation dose absorbed in a luminescent material. Portions of the luminescent material may be covered by different converters to allow for doses of different radiations to be discriminated. | 02-10-2011 |
20110031414 | DEVICE FOR MICROSCOPY HAVING SELECTIVE ILLUMINATION OF A PLANE - A microscopy device, particularly for use in an imaging fluorescence lifetime microscopy method is provided. The microscopy device comprises an illumination means for generating an illumination beam, an imaging detector for spatially resolved acquisition of an emission radiation emitted by an object to be examined, an illumination beam path between the illumination means and the object to be examined, and a detection beam path between the object to be examined and the detector. The illumination beam path comprises illumination optics which are designed to generate a light sheet of illumination radiation extending transverse to the axis of the illumination beam path, wherein the axis of the detection beam path is oriented substantially perpendicular to a section plane of the light sheet and of the object to be examined. The illumination means comprise a pulsed laser. | 02-10-2011 |
20110036994 | APPARATUS AND METHOD - An apparatus for investigating a molecule comprising a channel provided in a substrate, a metallic moiety capable of plasmon resonance which is associated with the channel in a position suitable for the electromagnetic field produced by the metallic moiety to interact with a molecule passing therethrough, means to induce a molecule to pass through the channel, means to induce surface plasmon resonance in the metallic moiety; and means to detect interaction between the electromagnetic field produced by the metallic moiety and a molecule passing through the channel. Methods of investigating molecules are also provided. | 02-17-2011 |
20110036995 | PATHOGEN DETECTION BY SIMULTANEOUS SIZE/FLUORESCENCE MEASUREMENT - A method and apparatus for detecting pathogens and particles in a fluid in which particle size and intrinsic fluorescence of a simple particle is determined, comprising a sample cell; a light source on one side of the sample cell for sending a focused beam of light through the sample, whereby portions of the beam of light are scattered at various angles by particles of various sizes present in the sample area; a particle size detector positioned in the light path for detecting a portion of forward scattered light; a pair of fluorescence detectors positioned off axis from the beam of light; and a pair of elliptical mirrors positioned such that an intersection of the incoming particle stream and the light beam are at one foci of each ellipsoid, and one of said pair of fluorescence detectors lies at the other foci. | 02-17-2011 |
20110036996 | APPARATUS AND METHOD FOR HIGH SPATIAL RESOLUTION IMAGING OF A STRUCTURE OF A SAMPLE - Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination. | 02-17-2011 |
20110042583 | OBSERVATION CHAMBER FOR STUDYING TEMPERATURE-DEPENDENT EVENTS AND METHOD THEREOF - Live-cell imaging chambers are used in a wide range of cell biology research. Recently, chambers capable of taking high-resolution and time-lapse images of live cells have been developed and become commercially available. However, since most of these chambers are designed to maintain a thermally stable environment for the cells under study, it is usually very difficult to use them to study temperature-dependent cellular events. The present invention provides a live-cell observation equipment for a non light-transmitting microscope to study temperature-dependent events and method thereof. | 02-24-2011 |
20110042584 | DEVICE FOR DETERMINING THE CONVERSION POWER - This invention relates to a device for determining the conversion power of conversion element, a method for performing these measurements and a method for producing pcLEDs with essentially the same color point applying said device and said method. The device comprises a light source ( | 02-24-2011 |
20110042585 | FIBER OPTICAL ASSEMBLY FOR FLUORESCENCE SPECTROMETRY - System and method for analyzing a sample for the presence of an analyte in a sample, the system comprising a sample holder for containing the sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed to the sample, and wherein the radiation induces a fluorescence signal; and at least one linear array comprising a proximal end disposed in proximity to the sample holder and an end port distal from the proximal end; a plurality of optical fibers extending from the proximal end to the end port and having a first end and a second end, wherein the first ends of the individual optical fibers are substantially coplanar and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal. | 02-24-2011 |
20110049389 | FLUORESCENT IMAGE OBTAINING DEVICE, FLUORESCENT IMAGE OBTAINING METHOD AND FLUORESCENT IMAGE OBTAINING PROGRAM - A fluorescent image obtaining device includes a light source that irradiates light such that a fluorescent material marked on a target in a biological sample lies in a non-excited state and a fluorescent material marked on a control with the target lies in an excited state, and an imaging unit that takes an image including the entire biological sample. | 03-03-2011 |
20110049390 | Method and Apparatus for Detection of Bioaerosols - A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol. | 03-03-2011 |
20110057118 | Method of Indirect Emission by Nano-materials - A method of indirect emission by nano-materials includes providing an infrared up-conversion phosphor 1 (weight ratio) and a long-wave ultraviolet phosphor 0.01-10 (weight ratio); treating both surfaces of the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; mixing the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; exciting the infrared up-conversion phosphor by a near-infrared laser with a wavelength of 980 mn to emit blue light as a secondary excitation lightsource; exciting the long-wave ultraviolet phosphor by the blue light to emit a visible light. Biological reactions can be conveniently detected by detecting the visible light. | 03-10-2011 |
20110057119 | Auto-synchronous fluorescence detection method and apparatus - An apparatus for time-gated fluorescence or luminescence detection includes gating means ( | 03-10-2011 |
20110068279 | ULTRA DARK FIELD MICROSCOPE - A fluorescence microscope includes a nearly monochromatic light source, a Brewster angle wedge, and an optical system for irradiating a sample with a light beam from the light source and directing fluorescence light from said sample onto the Brewster angle wedge. Collection optics are provided for focusing a hyper-spectral, wide angle and dark field image of the sample from the Brewster angle wedge onto recording optics. | 03-24-2011 |
20110068280 | DEVICE AND METHOD FOR SPATIAL RECONSTRUCTING OF FLUORESCENCE MAPPING - The invention concerns a method for locating at least one fluorophore or at least one absorber in a diffusing medium, using at least one excitation radiation and at least one fluorescence detector (Φ | 03-24-2011 |
20110084218 | METHOD AND DEVICE FOR PARTICLE ANALYSIS USING THERMOPHORESIS - The present invention pertains to a device and method to measure thermo-optical, preferably thermophoretic, characteristics of particles in a solution. The method comprises the steps of: (a) providing a sample probe comprising marked particles in a solution; (b) providing a temperature control system for creating a temperature gradient within said sample probe by contact heating, electrical heating and/or cooling; (c) detecting the marked particles at a first time; (d) creating a temperature gradient within the sample probe by means of the temperature control system; (e) detecting the marked particles in the sample probe at a, preferably predetermined, second time and/or at a predetermined location within the temperature gradient, and (f) characterizing the particles based on said two detections. | 04-14-2011 |
20110089341 | Fluorometers - In apparatus for the production and detection of fluorescence at a sample surface, the height of the apparatus above the sample surface is reduced, and loss of the emitted fluorescence due to reflection loss and light scattering is minimized. The apparatus comprises a three-dimensionally curved light reflecting surface ( | 04-21-2011 |
20110095203 | COLOR PROCESSING APPARATUS AND COLOR PROCESSING METHOD - A color processing apparatus according to the present invention is a color processing apparatus that calculates spectral reflectance including a fluorescent component in a sample under a target illuminant. The color processing apparatus includes first means for inputting, for each of a plurality of waveform types, spectral radiance including an excitation wavelength region and the amount of fluorescence in the sample corresponding to the spectral radiance; second means for determining, from spectral radiance of the target illuminant including the excitation wavelength region and the input spectral radiance and amount of fluorescence, the amount of fluorescence in the sample under the target illuminant; third means for inputting spectral reflectance excluding the fluorescent component in the sample; and fourth means for determining, by using the determined amount of fluorescence in the sample under the target illuminant and the input spectral reflectance excluding the fluorescent component in the sample, spectral reflectance including the fluorescent component in the sample under the target illuminant. | 04-28-2011 |
20110095204 | Method and apparatus for measuring the phase shift iduced in a light signal by a sample - A first light source emits a light signal along a measurement optical path that includes a sample and a second light source emits a light signal along a dummy measurement optical path. A measurement circuit receives the light signals and provides outputs separated in time which are indicative of the phase of the respective light signals. A phase shift is induced in light in the measurement optical path by the sample. A reference circuit receives a signal indicative of the phase of the light signals emitted by the first and second light sources. Circuitry compares the phases of light output from the two circuits to provide output indicative of a first measured phase difference during operation of the first light source. Correction is applied to this measurement by taking a similar phase difference measurement during operation of the second light source and comparing the two phase differences. | 04-28-2011 |
20110101240 | FLUORESCENT INK COMPOSITIONS COMPRISING FUNCTIONALIZED FLUORESCENT NANOCRYSTALS - A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder. Also provided are methods of providing an image or a security mark on a substrate for subsequent identification by applying a fluorescent ink composition onto the substrate. | 05-05-2011 |
20110101241 | Solid-State Photodetector Pixel and Photodetecting Method - A pixel is formed in a semiconductor substrate (S) with a plane surface for use in a photodetector. It comprises an active region for converting incident light (In) into charge carriers, photogates (PGL, PGM, PGR) for generating a lateral electric potential (Φ(x)) across the active region, and an integration gate (IG) for storing charge carriers generated in the active region and a dump site (Ddiff). The pixel further comprises separation-enhancing means (SL) for additionally enhancing charge separation in the active region and charge transport from the active region to the integration gate (IG). The separation-enhancing means (SL) are for instance a shield layer designed such that for a given lateral electric potential (Φ(x)), the incident light (In) does not impinge on the section from which the charge carriers would not be transported to the integration gate (IG). | 05-05-2011 |
20110101242 | METHODS, APPARATUS AND SYSTEMS EMPLOYING MULTIPLE ENERGY SOURCES FOR ANALYZING COMPOSITIONS - An apparatus for analyzing a composition includes an excitation source adapted to transmit incident energy, the excitation source comprising an array of energy emitting sources, and a plurality of photometric detectors adapted to receive radiation emitted from the composition when the incident radiation is transmitted thereto. | 05-05-2011 |
20110101243 | MICROARRAY CHARACTERIZATION SYSTEM AND METHOD - A system and method is described for detecting a plurality of analytes in a sample. The characterization system ( | 05-05-2011 |
20110108738 | DOPED LUMINESCENT MATERIALS AND PARTICLE DISCRIMINATION USING SAME - Doped luminescent materials are provided for converting excited triplet states to radiative hybrid states. The doped materials may be used to conduct pulse shape discrimination (PSD) using luminescence generated by harvested excited triplet states. The doped materials may also be used to detect particles using spectral shape discrimination (SSD). | 05-12-2011 |
20110108739 | METHOD FOR THE OPTICAL DETERMINING OF A MEASURED VARIABLE OF A MEDIUM - In a method for determining a measured variable of a measured medium, wherein the measured medium is brought in contact with an indicator or an indicator mixture, whose absorption spectrum has a first, and a second, wavelength range, which essentially do not overlap, | 05-12-2011 |
20110114854 | SLIDE TRANSFER MECHANISM FOR A LASER SCANNER DEVICE - A slide transfer mechanism for a laser scanner device ( | 05-19-2011 |
20110121202 | Optical Fiber Imaging System And Method For Generating Fluorescence Imaging - A nonlinear fluorescence imaging system and method for generating fluorescence imaging includes a pulsed laser source for generating laser pulses at a first wavelength and an optical pulse stretcher including one or more optical pulse stretcher fibers having a first dispersion parameter at the first wavelength. The system also includes a probe for interfacing with a sample to deliver the laser pulses and extract fluorescence signals excited in the sample. One or more optical delivery fibers are included for delivering the laser pulses and collecting nonlinear fluorescence signals. The optical delivery fiber has a second dispersion parameter at the first wavelength which is opposite a polarity of the first dispersion parameter. A detector detects images based on the collected fluorescence signals. | 05-26-2011 |
20110121203 | AUTHENTICATION APPARATUS FOR MOVING VALUE DOCUMENTS - An authentication apparatus used to authenticate a moving value document with uniform or non-uniform distribution of a pre-selected covert composition that includes an active ion that emits optical radiation at a pre-selected wavelength when excited by exciting incident light. The optical radiation is imaged onto at least one photodetector having first and second detector elements. The imaged intensities are captured at pre-determined times relating to the velocity of the value document. The ratio between the second detector element and the first detector element measured at the same image location or different image locations represents the characteristic decay time intensity data of the pre-selected wavelength emission. The authenticity of the value document is rejected when the pre-selected wavelength emission is not received by the at least one photodetector or when the output electronic signal ratio does not meet expected value. | 05-26-2011 |
20110121204 | TOTAL REFLECTION FLUORESCENCE OBSERVATION DEVICE - A technique and device for fluorescence observation with good operability, high sensitivity, acid high reliability. The device is used for fluorescence observation using evanescent light. The angle of incidence of the excitation light is adjusted so that the excitation light is always totally reflected from the surface of a substrate irrespective of the angle of the surface of the substrate. The method includes a step of shining the excitation light on the observation substrate while continuously varying the angle of the excitation light with respect to the observation substrate, a step of sensing the shone excitation light by means of optical sensors, and a step of setting the angle of total reflection according to the result of the sensing by the optical sensors. The direction in which the shone excitation light travels varies with the angle of incidence. That is, the excitation light travels as the transmitted light, the reflected light, or the surface propagating light. These lights are sensed by the corresponding optical sensors, and how the angle of incidence of the excitation light is with respect to the critical angle is determined. The angle of incidence of the excitation light is varied depending on the result of the determination, thereby realizing an optimum total reflection angle. | 05-26-2011 |
20110127445 | UPCONVERSION FLUORESCENT NANO-STRUCTURED MATERIAL AND USES THEREOF - Upconversion fluorescent nano-structured material(s) comprising at least one compound of formula (M | 06-02-2011 |
20110127446 | NANOSTRUCTURE SYSTEMS AND METHODS FOR SENSING AN ANALYTE - A method of detecting an analyte in an environment, includes immobilizing at least one photoactive composition on nanostructures, the photoactive composition exhibiting emission that is sensitive to the analyte; applying electromagnetic radiation to the immobilized photoactive moiety for a period of time; measuring at least one response; and using the measured response to determine the presence the analyte in the environment. The nanostructures can, for example, include carbon nanostructures. In a number of embodiments, the analyte is oxygen. | 06-02-2011 |
20110133100 | METHOD OF PUMPING QUANTUM DOTS - Strongly confined semiconductor quantum dots theoretically offer for broadband and continuous tunability of their emitting wavelength based upon simply varying the particle size. However, prior art consistently has demonstrated a lower particle size limit below which optical gain cannot be achieved, for example 2.3 nm for CdSe in toluene. As such the prior art points to combinations of alternative materials and host media as the route to achieving the goal of broadband emission sources using quantum dots. However, according to the invention optical gain can be achieved in quantum dots below these previous experimental limits by resonantly pumping the quantum dots to a specific excitonic state, i.e. electron position relative to the quantum dot, such that the multiexcitonic interferences are minimized. Using this approach optical gain in CdSe of R=2.1 nm and 1.5 nm has been demonstrated in the yellow/amber region of the visible spectrum. | 06-09-2011 |
20110133101 | MODULAR IMAGING SYSTEM, MODULES FOR THIS SYSTEM AND METHOD IMPLEMENTED USING THIS SYSTEM - An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber. | 06-09-2011 |
20110140003 | Test apparatus for an optical investigation system - A test apparatus for an optical investigation system, with an imaging device and a light source for optical investigation of an object in remitted light and/or fluorescent light includes a housing with a hollow space and an aperture for inserting a distal end of the imaging device into the hollow space, a reference surface with predetermined optical properties in the hollow space, at least either for remission of illuminating light directed onto the reference surface or for emission of fluorescent light, and a positioning device to hold the imaging device of the distal end of the imaging device at a predetermined position in relation to the reference surface. | 06-16-2011 |
20110140004 | GLASS ARTICLE WITH IDENTIFICATION MEANS AND METHOD FOR IDENTIFYING A GLASS ARTICLE - A glass article comprising identification means and a method for detecting the presence of the said identification means are disclosed. The glass article comprises at least one glass sheet which is covered by a layer comprising dispersed and invisible identification means. The identification means according to the invention allows identification of the presence of an intrinsic characteristic of said glass article which is invisible to the naked eye or difficult to detect. | 06-16-2011 |
20110147614 | REFRACTIVE INDEX MATCHED PHOSPHORS AND SUBSTRATES FOR SECURITY APPLICATIONS - Phosphor compositions are provided that can be incorporated into or onto plastic substrates as covert security features. The plastic substrates can be transparent and the phosphor compositions have a refractive index that effectively matches the refractive index of the plastic substrate to maintain the transparency. The phosphor compositions have absorption in the infrared, thus enabling excitation and detection of the compositions with an infrared emitting source. | 06-23-2011 |
20110147615 | Method and apparatus for microscopic imaging system with wide field of view and high collection efficiency - A microscopic imaging system using a laser excitation source, a scanner system, an optical relay system, a first focusing lens, a sample container and a detection system is used to examine tissue and other biological samples. The microscopic imaging system uses a relay optics and simplified compact object to produce a curved image plane in the sample and a method for transforming the curved image field into Cartesian coordinates is described. The system can incorporate a focus compensation system within the compact object to improve the imaging through the sample. The system can incorporate a sample chamber with integrated optics to improve the collection efficiency of the detection system in the microscopic imaging system. The system can incorporate a movable mirror with other fold mirrors to allow for multi-sided imaging of a sample. | 06-23-2011 |
20110147616 | COHERENT NONLINEAR MICROSCOPY SYSTEM AND METHOD WITH VARIATION OF THE FOCAL VOLUME IN ORDER TO PROBE THE NANOSTRUCTURE OF ORGANIZED MATERIALS - A method for the dimensional characterization of a structured material, in which method: an excitation laser beam suitable for coherent nonlinear microscopy is generated, this excitation laser beam being focused in a focal volume within the structured material; signals emitted by the structured material are detected; a plurality of emission patterns, each corresponding to one particular shape of the focal volume, is produced, the particular shapes being obtained for various non-Gaussian spatial profiles of the excitation laser beam wavefront; and on the basis of the emission patterns thus produced, dimensional characteristics of the structured material are deduced therefrom. | 06-23-2011 |
20110155926 | QUANTUM EFFICIENCY MEASUREMENT APPARATUS AND QUANTUM EFFICIENCY MEASUREMENT METHOD - A sample that is an object whose quantum efficiency is to be measured, and a standard object having a known reflectance characteristic are each attached to a sample window provided in a plane mirror. Based on respective spectrums measured by a spectrometer in respective cases where the sample is attached and the standard object is attached, the quantum efficiency of the sample is measured. The plane of an opening of an observation window is made substantially coincident with the exposed surface of the sample or standard object, so that direct incidence, on the observation window, of the fluorescence generated from the sample receiving an excitation light and the excitation light reflected from sample is prevented. | 06-30-2011 |
20110155927 | Non-Orthogonal Particle Detection Systems and Methods - Described herein is a particle detection system capable of spatially resolving the interaction of particles with a beam of electromagnetic radiation. Using a specific electromagnetic beam cross sectional shape and orientation, the detection sensitivity of a particle detection system can be improved. Also provided are methods for detecting and sizing particles in a manner that has low background signal and allows for spatially resolving the scattering or emission of electromagnetic radiation from particles. | 06-30-2011 |
20110168914 | MICROSCOPY SYSTEM, MICROSCOPY METHOD AND METHOD OF TREATING AN ANEURYSM - A microscopy system and method are provided allowing observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images. | 07-14-2011 |
20110168915 | Fluorescence Imaging Apparatus and Method for Detecting Fluorescent Image - In order to reduce light leak influencing the detection capability of a fluorescence imaging apparatus, an interference filter and an absorption filter on an emission-side filter section are arranged serially in the traveling direction of the fluorescence. The interference filter and the absorption filter that are in use for such an arrangement block the waveband light equivalent to the excitation light irradiated onto a sample while fully transmitting the waveband light equivalent to the fluorescence. | 07-14-2011 |
20110168916 | FLUORESCENCE DETECTION DEVICE USING INTENSITY-MODULATED LASER LIGHT AND FLUORESCENCE DETECTION METHOD - Fluorescence detection device employed in a flow site meter emits laser light intensity-modulated by a modulation signal and acquires the fluorescence signal of fluorescence emitted from a measurement object passing through a measurement point of the laser light. The device generates the reference signal, separately from the modulation signal, the reference signal having a frequency different from the frequency of the modulation signal and having a phase synchronized with a phase of the modulation. The device determines fluorescence relaxation time of the measurement object from the fluorescence signal using the reference signal. | 07-14-2011 |
20110168917 | FLUORESCENCE DETECTION DEVICE USING INTENSITY-MODULATED LASER LIGHT AND FLUORESCENCE DETECTION METHOD - A fluorescence detection device for a flow site meter emits laser light intensity-modulated in accordance with a modulation signal and acquires a fluorescent signal of fluorescence emitted from a measurement object that passes through a measurement point of the laser light. The fluorescence detection device generates, separately from the modulation signal, a reference signal having a frequency different from a frequency of the modulation signal and a phase in synchronization with a phase of the modulation signal. The fluorescence detection device determines a fluorescent relaxation time of the measurement object from the fluorescent signal by using the reference signal. | 07-14-2011 |
20110168918 | DETECTION SYSTEM AND METHOD - A detection system combines an excitation radiation source ( | 07-14-2011 |
20110174987 | Spectroscopic Device, and Method for Driving the Device - Provided is a spectroscopic device of a new constitution, which is suited for detecting precisely a fluorescent light emitted from an inspection object in a fluorometric analysis, such as a DNA. The spectroscopic device ( | 07-21-2011 |
20110174988 | METHOD AND APPARATUS FOR QUANTITATIVE EVALUATION OF WALL ZETA-POTENTIAL, AND METHOD AND APPARATUS FOR QUANTITATIVE VISUALIZATION OF SURFACE MODIFICATION PATTERN - A first and a second fluorescent dye are mixed into a solution, the first dye being positively ionized in the solution and the second dye being negatively ionized in the solution and having different fluorescence wavelength from the first dye. The solution is flown onto a measured surface, and the surface is excited with an evanescent wave to produce a fluorescence intensity distribution of two colors. A fluorescence intensity of the surface is measured using a two-dimensional imaging element, the element providing a fluorescence intensity of each color separated from the other colors, thereby calculating a ratio of the fluorescence intensities of the colors. Using an equation expressing a relationship between the ratio of fluorescence intensities and wall zeta potential, the ratio is converted to a two-dimensional distribution of wall zeta potentials. This achieves visualizing in real time and quantitatively evaluating the two-dimensional distribution of wall zeta potentials, and surface modifications. | 07-21-2011 |
20110180726 | SYSTEM AND METHOD FOR DIGITAL PARALLEL FREQUENCY FLUOROMETRY - A system and method is provided for improved fluorescence decay time measurement. A digital heterodyning technique is disclosed in which a photon detector is sampled at a rate slightly faster than a digitally pulsed excitation signal. A resulting cross correlation frequency is low enough to be read by inexpensive electronics such as by a field programmable gate array. Phase information in the signal provides correlation with corresponding photon detections. | 07-28-2011 |
20110180727 | APPARATUS AND A METHOD OF DETERMINING THE PRESENCE OF AN ALUMINA LAYER ON A SURFACE OF A COMPONENT - Provided is a method for determining the presence of an alumina layer on a surface of a component. The method includes illuminating a surface of a component with radiation; detecting radiation emitted at a particular wavelength; analyzing the detected radiation; to determine the thickness of the alumina at at least one point on the surface of the component; and comparing the determined thickness of the alumina at the at least one point on the surface of the component with a predetermined thickness of alumina at that point to decide if the thickness of alumina at the at least one point on the surface of the component is satisfactory. | 07-28-2011 |
20110186752 | METHOD AND DEVICE FOR DETERMINING THE RATIO BETWEEN THE CONTENTS OF CHLOROPHYLL AND OF A CHROMOPHORE COMPOUND IN A VEGETABLE TISSUE WITHOUT INDEPENDENTLY MEASURING SAID CONTENTS - A method and device for determining the ratio of the contents of chlorophyll and of a chromophorous compound that is non-fluorescent in the band of chlorophyll fluorescence in a plant tissue, without determining the contents. The method includes:
| 08-04-2011 |
20110186753 | METHOD AND APPARATUS FOR DETERMINING THE PRESENCE OF OPTICAL BRIGHTENERS IN WATER SAMPLES - An apparatus and method for making quantitative measurements of the amounts of optical brighteners in water samples using fluorescence measurements at multiple wavelengths. First and second emission wavelength raw measurements are corrected for sample absorption to provide absorption-corrected first emission wavelength and second emission wavelength fluorescence emission values. The absorption-corrected first emission wavelength value is compared to the absorption-corrected second emission wavelength value and to similarly-determined and similarly absorption-corrected emission wavelength values or a ratio thereof obtained from a comparison water sample in which optical brighteners are not present or are only minimally present, to provide a quantitative optical brightener measurement. The apparatus and method may be field-based or laboratory-based, and may operate on a flow-through basis or on discrete samples. | 08-04-2011 |
20110186754 | Device for the Optical Imaging of a Sample - In a device for the optical imaging of a sample, having at least one light source for excitation light in order to excite a fluorescent dye in a sample, which is held by a sample holder, for spontaneous emission of fluorescent light over a limited period of time in a spatial region having increased resolution, and for de-excitation light in order to de-excite the fluorescent dye again except for a residual zone that is reduced in size relative to the spatial region, wherein light from the sample having wavelengths other than those of the excitation light and of the de-excitation light is assignable to the spontaneous emission of fluorescent light from the residual zone of the spatial region (STED, GSD, etc.), the de-excitation light ( | 08-04-2011 |
20110192991 | MICROPARTICLE ANALYSIS DEVICE AND MICROPARTICLE ANALYSIS METHOD - Disclosed herein is a microparticle analysis device including: a light source configured to irradiate a microparticle with light; an acousto-optic modulator configured to diffract fluorescence generated from the microparticle due to the light irradiation; a slit configured to allow transmission of only diffracted light in a diffraction center wavelength region among diffracted light beams from the acousto-optic modulator; and a detector configured to detect the diffracted light in the diffraction center wavelength region transmitted through the slit. | 08-11-2011 |
20110192992 | SCANNER PHOTOMETER METHODS - A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are like-wise provided, operatively interposed before or after the objective lens as the case may be. | 08-11-2011 |
20110204257 | HAEMOZOIN DETECTION - A system for detecting haemozoin in a sample, said system including a light source for exciting the sample with an optical signal to generate a non-linear optical response, and a detector for detecting the generated non-linear optical response from the excited sample. A method for detecting haemozoin in a sample, the method including exciting the sample with an optical signal to generate a non-linear optical response from the sample, and detecting the emitted non-linear optical signal from the excited sample. | 08-25-2011 |
20110204258 | SPECTRAL IMAGING OF PHOTOLUMINESCENT MATERIALS - A near infrared imaging and detection system is configured to analyze shifts in photoluminescence of individual nanostructures such as single-walled carbon nanotubes or quantum dots upon binding an analyte. The system can be used to detect, localize, and quantify analytes down to the single-molecule level in a sample and within living cells and can be operated in a multiplex format. The system also can be configured to perform high-throughput chemical analysis of a large number of samples simultaneously. The invention has application in the highly sensitive diagnosis of disease, as well as the detection and quantitative analysis of drugs, molecular pathogens within a living organism, and environmental toxins. | 08-25-2011 |
20110204259 | METHOD AND SYSTEM FOR DETECTING FLUOROCHROMES IN A FLOW CYTOMETER - A method for detecting fluorochromes in a flow cytometer, including: receiving a sample including particles each tagged with at least one of a first fluorochrome and a second fluorochrome, in which the first and second fluorochromes having distinct spillover coefficients; detecting the particles, including detecting the first and second fluorochromes with a first detector and a second detector; forming a data set for detected particles based on the detection of the first and second fluorochromes; characterizing a detected spillover coefficient for each detected fluorochrome from the data set; and sorting the detected particles into predicted fluorochrome populations based on the detected spillover coefficients. A system for detecting fluorochromes in a flow cytometer, including a flow cell, a fixed gain detection system, and a processor that generates a detected spillover coefficient for each detected particle and sorts the detected particle into predicted fluorochrome populations based on the detected spillover coefficient. | 08-25-2011 |
20110210271 | Detector System For Unidentified Substances - Disclosed herein is a detection system for identifying an unidentified substance in a sample, comprising a light emitting source; a circuit board; a trigger, that activates a pulse of electrons from the circuit board to the light emitting source such that the light emitting source emits light; a detector for collecting light from the unidentified substance; and a central processing unit for analyzing the collected light to identify the unidentified substance. | 09-01-2011 |
20110210272 | Methods and Products for Analyzing Polymers - Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers. | 09-01-2011 |
20110215258 | Method and Arrangement for Collimated Microscopic Imaging - A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions. | 09-08-2011 |
20110226962 | METHOD AND APPARATUS FOR DETECTING FLUORESCENCE EMITTED BY PARTICLE-BOUND FLUOROPHORES CONFINED BY PARTICLE TRAPS - A method of detecting a fluorescence signal emitted by fluorophores bound to particles confined in a particle trap, includes an objective lens having a focal plane, which is normally the focal plane for incident collimated light. The particle trap is typically located in the focal plane, and a beam of excitation light is directed via the objective lens onto the confined particles in the trap. The excitation light is in the form of a divergent beam coming to focus at a plane displaced from the focal plane. The divergent beam has a spot diameter at the focal plane determined by the divergence of the beam. The fluorescent light emitted by the fluorophores is detected with a confocal detector. | 09-22-2011 |
20110226963 | METHOD AND APPARATUS FOR PERFORMING MULTIPOINT FCS - A method of performing fluorescence correlation spectroscopy with a fluorescence microscope includes selecting an illumination area of a sample, generating an illumination light beam and splitting the illumination light beam into at least three partial beams. The partial light beams are focused onto the selected illumination area using a microscope optical system of the fluorescence microscope so as to excite fluorescent dye particles in the illumination area to fluoresce. Fluorescent light emitted by the dye particles is detected and at least one diffusion coefficient representative of a diffusibility of the fluorescent dye particles is determined based on the detected fluorescent light. | 09-22-2011 |
20110226964 | PARTICLE OR CELL ANALYZER AND METHOD - A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles. | 09-22-2011 |
20110226965 | INCREASED RESOLUTION MICROSCOPY - Method for spatially high-resolution luminescence microscopy in which label molecules in a sample are activated to emit luminescence radiation comprising activating only a subset of the label molecules in the sample, wherein activated label molecules have a distance to the closest activated molecules that is greater or equal to a length which results from a predetermined optical resolution, detecting the luminescence radiation, generating a frame from the luminescence radiation, identifying the geometric locations of the label molecules with a spatial resolution increased above the predetermined optical resolution, repeating the steps and forming a combined image, and controlling the acquisition of the several frames by evaluating at least one of the frames or a group of the frames and modifying at least one variable for subsequent repetitions of the steps of generating frames for combining into an image. | 09-22-2011 |
20110233427 | MAGNETITE-SILVER HETERODIMER NANOPARTICLES AND THEIR PREPARATION AND USE FOR TWO-PHOTON FLUORESCENCE - A heterodimer particle is provided which comprises a first component particle comprising magnetite and a second component particle comprising silver. The second component particle may have a structure and a particle size selected to generate two-photon fluorescence emission. The heterodimer particle may be irradiated with light of a wavelength selected to induce two-photon fluorescence emission, which is then detected. Tetramethylammonium hydroxide may be bonded to the surface of the first component and glutathione may be bonded to the surface of the second component. The heterodimer particle may be formed by preparing a magnetite particle and growing a silver particle on the magnetite particle, in the presence of 1,2-dodecanediol as a reducing agent. | 09-29-2011 |
20110240885 | Broadband Solid-State Illuminator for Fluorimetry Device and System - An improved solid-state light source ( | 10-06-2011 |
20110266459 | MULTI-FUNCTIONING MATERIAL COMPOSITIONS, STRUCTURES INCORPORATING THE SAME AND METHODS FOR DETECTING AGEING IN LUMINESCENT MATERIAL COMPOSITIONS - A multi-functional material composition comprising a zirconia host and containing a luminescent lanthanide oxide additive, in particular dysprosia (D | 11-03-2011 |
20110266460 | Method and a Device for Detecting the Fluorescence of a Biochip - An imaging method and a device for detecting the fluorescence of a biochip by illuminating chromophores associated with probes ( | 11-03-2011 |
20110266461 | METHOD AND A DEVICE FOR MEASURING FLUORESCENCE LIFETIME - The invention refers to a method for measuring fluorescence lifetime. An excitation light radiation ( | 11-03-2011 |
20110266462 | FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - When a fluorescence relaxation time of a fluorochrome is determined using a measurement object obtained by attaching the fluorochrome to an analyte, a first laser beam is intensity-modulated by a modulation signal with a frequency of f | 11-03-2011 |
20110272597 | METHOD FOR GENERATING OPTICAL TOMOGRAPHIC INFORMATION, OPTICAL TOMOGRAPHIC INFORMATION GENERATING APPARATUS, AND STORAGE MEDIUM - Measurement data of intensities of fluorescence obtained by directing excitation light onto a subject is acquired. An initial value of an absorption coefficient of the phosphor is set on the basis of a concentration distribution of the phosphor, an intensity distribution of the fluorescence on the basis of an absorption coefficient and a diffusion coefficient (reduced scattering coefficient) of the subject, which are set beforehand, are calculated, and the measurement data is compared with the calculation result. If these are found not to be matched, an absorption coefficient of the phosphor at which the error will be a minimum is estimated by performing an inverse problem calculation using a mathematical model. The calculation of the intensity distribution of the fluorescence and evaluation of the error from the obtained concentration distribution are repeated using the absorption coefficient, and a concentration distribution for which the error is the minimum is acquired. | 11-10-2011 |
20110278470 | HIGH DYNAMIC RANGE SCANNING WITH REDUCED CHANNEL CROSS-TALK - A multi-channel scanning system adapted to implement a low channel cross-talk, extra-wide dynamic range scanning method by scanning the same location more than once, wherein at least one time, the power of the excitation light and detector gain are set to High for at least one of the channels and Low for at least one of the other channels and different settings are used in subsequent scans. The scans of the same channel taken with different High and Low settings are merged together to produce one wider dynamic range image. | 11-17-2011 |
20110278471 | FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - In order to remove autofluorescence emitted by a measurement object, fluorescence of the measurement object within a first wavelength band is first received. The first wavelength band is set so that the intensity of fluorescence emitted by the measurement object irradiated with intensity-modulated laser light is higher than that of autofluorescence emitted by the measurement object irradiated with the laser light. Then, the autofluorescence within a second wavelength band different from the first wavelength band is received. A generated fluorescent signal of the first fluorescence and a generated fluorescent signal of the autofluorescence are mixed with a modulation signal for modulating the laser light to produce first fluorescence data and autofluorescence data, respectively. The autofluorescence data is multiplied by a predetermined constant, and the thus obtained result is subtracted from the first fluorescence data to produce third fluorescence data. The third fluorescence data is used to calculate a fluorescence intensity. | 11-17-2011 |
20110278472 | OPTICAL DETECTION UTILIZING CARTRIDGE WITH TUNABLE FILTER ASSEMBLY - A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges is a wavelength-tunable cartridge in which different light sources, excitation filters, and/or emission filters may be selected. Tuning is further accomplished by tilting the excitation or emission filters at desired angles relative to a beam of exciting light or emitted light. | 11-17-2011 |
20110278473 | METHOD FOR MAKING SECURITY LASER PRINTING FILM - A laser markable security laser transfer film includes a carrier web formed from a laser light-transmissive material and a taggant-containing film disposed on the carrier web. The taggant-containing film is formulated from an energy sensitive taggant capable of withstanding temperatures of at least about | 11-17-2011 |
20110278474 | Axial Illumination for Capillary Electrophoresis - System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. | 11-17-2011 |
20110278475 | MULTIPLEX ILLUMINATION SYSTEM AND METHOD - Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection from such high density arrays. Systems and methods comprise substrates having an array of discrete signal sources having a pitch P | 11-17-2011 |
20110284767 | COMBINATION MICROSCOPY - A method for generating an image of a sample by a microscopy method including varying local resolution, wherein at least two of the following microscopy methods are combined: laser scanning microscopy, a microscopy method wherein the sample is excited to luminescence by structured line or wide area illumination, and a first microscopy image is generated from the images thus obtained, having increased local resolution greater than the optical resolution of the image, a further microscopy method according to the PAL principle, by which a second microscopy image is generated, indicating geometric locations of marker molecules emitting luminescent radiation at an increased local resolution relative to the optical resolution, and a further microscopy method, wherein the sample is marked using marking molecules suitable for the STED, ESA, or RESOLFT technique, and a third microscopy image is generated of STED, ESA, or RESOLFT, wherein the obtained images are superimposed. | 11-24-2011 |
20110284768 | FLUORESCENCE ANALYZING DEVICE AND FLUORESCENCE ANALYZING METHOD - The present invention has an object to provide a method for efficiently detecting an image with a smaller number of pixels. | 11-24-2011 |
20110284769 | TOTAL INTERNAL REFLECTION MICROSCOPE APPARATUS AND METHOD FOR ANALYZING FLUORESCENT SAMPLE - An object of the present invention relates to observation of single molecule fluorescence while temperature of a sample solution is controlled by a temperature controller and intrinsic fluorescence of the temperature controller is avoided, in a total internal reflection microscope. The present invention relates to provision of an opening at areas of the temperature controller through which incident light and reflected light pass, and configuration adopting a material with intrinsic fluorescence lower than that of the other parts, in a total internal reflection microscope including a prism and the temperature controller. The present invention enables intrinsic fluorescence of the temperature controller to be suppressed, which allows highly sensitive fluorescence observation while controlling sample solution temperature with high precision. For instance, this in turn allows the throughput of single molecule DNA sequencing using a total internal reflection microscope to be improved. | 11-24-2011 |
20110284770 | FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD - A fluorescence detecting device generates a modulation signal for modulating an intensity of laser light and modulates the laser light by using the modulation signal, when receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit. The fluorescence detecting device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light and calculates, from the fluorescent signal, the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detecting device controls the frequency of the modulation signal so that the value of the phase delay comes close to a preset value. The fluorescence detecting device calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object by using a phase delay obtained under the condition of frequency of the modulation signal at the time when the control is settled. | 11-24-2011 |
20110291027 | METHODS AND SYSTEMS FOR SIMULTANEOUS REAL-TIME MONITORING OF OPTICAL SIGNALS FROM MULTIPLE SOURCES - Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing. | 12-01-2011 |
20110297846 | ELECTRON INJECTION NANOSTRUCTURED SEMICONDUCTOR MATERIAL ANODE ELECTROLUMINESCENCE METHOD AND DEVICE - Embodiments of the invention include methods and devices for producing light by injecting electrons from field emission cathode across a gap into nanostructured semiconductor materials, electrons issue from a separate field emitter cathode and are accelerated by a voltage across a gap towards the surface of the nanostructured material that forms part of the anode. At the nanostructure material, the electrons undergo electron-hole (e-h) recombination resulting in electroluminescent (EL) emission. In a preferred embodiment lighting device, a vacuum enclosure houses a field emitter cathode. The vacuum enclosure also houses an anode that is separated by a gap from said cathode and disposed to receive electrons emitted from the cathode. The anode includes semiconductor light emitting nano structures that accept injection of electrons from the cathode and generate photons in response to the injection of electrons. External electrode contacts permit application of a voltage differential across the anode and cathode to stimulate electron emissions from the cathode and resultant photon emissions from the semiconductor light emitting nanostructures of the anode. Embodiments of the invention also include the usage of nanostructured semiconductor materials as phosphors for conventional planar LED and nanowire array light emitting diodes and CFL. For the use in conventional planar LEDs, the nanostructures may take the form of quantum dots, nanotubes, branched tree-like nanostructure, nanoflower, tetrapods, tripods, axial heterostructures nanowires hetero structures. | 12-08-2011 |
20110297847 | Fluorescence Microscopy Methods and Apparatus - Methods and apparatus are provided concerning the control of photobleaching of fluorescent labels during the study of samples by fluorescence microscopy. A method is described for operating fluorescence microscopy apparatus to analyse a sample ( | 12-08-2011 |
20110297848 | NON-INVASIVE METHODS AND APPARATUS FOR DETECTING INSECT-INDUCED DAMAGE IN A PLANT - Lesions caused by insects feeding on plants are associated with the generation of regions of blue-green fluorescence in such as the cotton boll carpel wall and in the lint region. The present disclosure now provides methods and devices to rapidly and non-invasively detect and measure the insect-related fluorescence and relate the fluorescence generated to the likelihood of insect damage in a crop. In particular, the methods are related to stink bug damage in the cotton plant, but are also suitable for the detection of insect-related damage of any plant. The methods of detecting insect-induced damage in a target plant tissue may comprise exposing a target plant or a fragment thereof, to an ultraviolet or violet light; and detecting an ultraviolet light-induced fluorescence from the target plant or the fragment thereof, thereby indicating the presence of insect-related plant damage. Further provided are devices configured for the identification of insect-induced damage in a plant or a fragment thereof, comprising: a source of an ultraviolet or violet light, at least one light detector; an electronic system for converting an output electrical signal to a measurement of the intensity of fluorescent light detected by the detector; and an output system to convert the measurement of the intensity of the fluorescent light to an indicator for indicating that a target plant or fragment thereof has insect-induced damage. | 12-08-2011 |
20110303856 | DETECTION METHOD BASED ON WHISPERING GALLERY MODES IN MICROSPHERES FLOATING IN A SOLUTION UNDER TEST - The detection method can include: exciting at least one fluorescent microsphere floating in said solution under test by exposing it to excitation light; measuring a fluorescence spectrum of said at least one fluorescent microsphere, said fluorescence spectrum comprising multiple whispering gallery modes; obtaining a set of predetermined fluorescence spectra corresponding to those of microspheres having varying external refractive index and varying radius, identifying a matching fluorescence spectrum of the set which more closely matches the measured fluorescence spectrum; comparing the matching fluorescence spectrum of the set to the measured fluorescence spectrum. | 12-15-2011 |
20110309265 | DIAMOND NANOWIRES - In a general aspect, a system includes a plurality of diamond nanowires disposed on the surface of a diamond substrate, at least some of the nanowires including a color center. The system also includes a light source configured to illuminate at least one of the plurality of nanowires with excitation light at a wavelength corresponding to an excitation wavelength of the color center included in the illuminated nanowire; and an optical receiver configured to receive a fluorescence emitted from the color center included in the illuminated nanowire in response to the excitation light. | 12-22-2011 |
20110309266 | FLUORESCENCE DETECTION METHOD, FLUORESCENCE DETECTING DEVICE AND PROGRAM - Disclosed herein is a fluorescence detection method. The fluorescence detection method includes the steps of: irradiating a measurement object with laser light modulated at a predetermined frequency; receiving fluorescence emitted by the measurement object and outputting two or more pulsed fluorescent signals; setting reference timing in units of period corresponding to the frequency; acquiring a generation time to output of each of the pulsed fluorescent signals based on the reference timing; generating a cumulative fluorescent signal indicating the relationship between a generation frequency of the pulsed fluorescent signal and the generation time; determining, by using a signal corresponding to modulation of the laser light as a reference signal, a phase difference between the reference signal and the cumulative fluorescent signal; and determining, by using the phase difference, a fluorescence relaxation time of the fluorescence emitted by the measurement object. | 12-22-2011 |
20110315894 | Apparatus For and Method of Measuring Bio-Chips Using Uniform Total Internal Reflection Illumination - Disclosed herein is an apparatus for and method of measuring bio-chips, which can implement an illumination method of a novel type that illuminates a bio sample (which may be also referred to as a “bio specimen”) through a side face of a substrate using a diffusion plate to form an evanescent field by the illumination light over the entire surface of a substrate so as to uniformly secure brightness of the illuminated light over a wide area of a substrate, thereby more efficiently measuring fluorescence information of a bio-chip over a wide field of view. | 12-29-2011 |
20110315895 | LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM | 12-29-2011 |
20110315896 | LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM | 12-29-2011 |
20120001090 | MINUTE PARTICLE ANALYZING DEVICE AND METHOD - A minute particle analyzing device includes: a light source; a first condenser lens for condensing light from the light source to a first end of a multimode optical fiber; a second condenser lens for condensing the light emerging from a second end of the multimode optical fiber to a minute particle; and a detector for detecting light generated from the minute particle by the application of the light from the light source. | 01-05-2012 |
20120001091 | LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM | 01-05-2012 |
20120001092 | LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM | 01-05-2012 |
20120001093 | LUMINESCENT GLASS ELEMENT, PRODUCING METHOD THEREOF AND LUMINESCING METHOD THEREOF - The present invention relates to a luminescent glass element comprising a luminescent glass substrate, which a metal layer is positioned on a surface thereof. The metal layer is provided with a metal microstructure. The luminescent glass substrate has composite oxides represented as the following formula: aM | 01-05-2012 |
20120007001 | FLUOROSCOPY SYSTEM, FLUOROSCOPY APPARATUS, AND FLUOROSCOPY METHOD - Observation is performed with a fluorescence image having high quantitativeness by satisfactorily eliminating dependencies on distance and angle that remain in an image subjected to division. Provided is a fluoroscopy system | 01-12-2012 |
20120012756 | Photoluminescence Spectroscopy - This invention relates to temperature-corrected photoluminescence spectroscopy which may be applied to semiconductors and, in particular, photovoltaic films. | 01-19-2012 |
20120012757 | Non-Orthogonal Particle Detection Systems and Methods - Described herein is a particle detection system capable of spatially resolving the interaction of particles with a beam of electromagnetic radiation. Using a specific electromagnetic beam cross sectional shape and orientation, the detection sensitivity of a particle detection system can be improved. Also provided are methods for detecting and sizing particles in a manner that has low background signal and allows for spatially resolving the scattering or emission of electromagnetic radiation from particles. | 01-19-2012 |
20120018651 | NANOSCALE IMAGING OF MOLECULAR POSITIONS AND ANISOTROPIES - A Polarization Fluorescence Photoactivation Localization Microscopy (P-FPALM) system and method are provided to simultaneously image the localizations and fluorescence anisotropics of large numbers of single molecules within a sample. The system modifies known FPALM systems by adding a polarizing beam splitter. The beam splitter polarizes emissions perpendicular and parallel to an axis in the sample to allow spatially separate imaging of fluorescence emitted from a sample. The system includes lenses and mirrors so that the separate, polarized beams are detected simultaneously. The present invention includes methods of using the system to image localizations and fluorescence anisotropics of single molecules, and methods of using data obtained with the system to predict 3-D orientation of the molecules. The system and method achieve substantially improved lateral resolution within even dense samples over known microscopic imaging techniques, and does not compromise speed or sensitivity. | 01-26-2012 |
20120025098 | FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - When receiving fluorescence emitted by a measurement object irradiated with laser light emitted from a laser light source unit, a fluorescence detection device generates a modulation signal for modulating the intensity of the laser light and modulates the laser light using the modulation signal. The fluorescence detection device obtains a fluorescent signal of the fluorescence emitted by the measurement object irradiated with the laser light, and calculates, from the fluorescent signal, a fluorescence intensity and the phase delay of the fluorescence with respect to the modulation signal. At the time, the fluorescence detection device controls the operation amounts of the signal level of a DC component of the modulation signal and the gain of amplification just after the output of the fluorescent signal so that the value of a fluorescence intensity signal falls within a preset range. After the operation amounts are settled, the fluorescence detection device calculates the fluorescence intensity and then calculates the fluorescence relaxation time of the fluorescence emitted by the measurement object using the phase delay. | 02-02-2012 |
20120025099 | SYSTEMS AND METHODS FOR SPECTRALLY ENCODED IMAGING - A method of forming an image of a target that comprises illuminating a target with light, maneuvering an optical unit having at least one diffractive element in front of the target through a plurality of positions, capturing, during the maneuvering, a plurality of spectrally encoded frames each from a portion of the light that is scattered from a different of a plurality of overlapping segments along a track traversing an image plane of the target, and combining the plurality of spectrally encoded frames to form a composite multispectral image of at least a portion of said target. | 02-02-2012 |
20120025100 | PHOTOLUMINESCENCE MEASUREMENT - A photoluminescence measurement system can include an optical source. | 02-02-2012 |
20120025101 | METHOD OF DECOMPOSING CONSTITUENTS OF A TEST SAMPLE AND ESTIMATING FLUORESCENCE LIFETIME - The present invention relates to a method of decomposition of a test sample into constituents thereof. The method proceeds by optically imaging the test sample to obtain a corresponding unknown time-domain resolved signal and decomposes the unknown time-domain resolved signal by comparing the unknown time-domain resolved signal with time-domain resolved reference signals. Furthermore, the method allows the determination of the presence or absence of constituents. Relative quantities may also be determined if sample material properties are known or taken into account. Lifetime decay of the constituents may also be estimated by handling effect of light diffusion in the test sample as time decay. | 02-02-2012 |
20120032093 | TAGGED SCALE INHIBITOR COMPOSITIONS AND METHODS OF INHIBITING SCALE - Scale inhibitor compositions and methods of inhibiting scale formation generally include a tagged scale inhibiting (co)polymer including at least one scale inhibiting moiety and an imidazole moiety. The imidazole moiety fluoresces at a wavelength of about 424 nm and can be used to detect the amount of scale inhibitor present. | 02-09-2012 |
20120032094 | PROCESSING A FLUORESCENCE IMAGE BY FACTORIZING INTO NON-NEGATIVE MATRICES - A method for locating at least one fluorescent tag in a scattering medium, wherein: a) at least one tag is introduced into the medium, b) a fluorescence image is performed by an infrared excitation of the medium along a first axis, the image including a fluorescence component due to the tag, and an auto-fluorescence component due to a medium part other than the tags, c) the image is processed by factorizing into two non-negative matrices, and d) an image of the distribution of the tag(s) is determined, without the auto-fluorescence component. | 02-09-2012 |
20120032095 | METHOD AND APPARATUS FOR DETECTING PHARMACEUTICALS IN A SAMPLE - A method and apparatus for measuring a vitamin K antagonizing anticoagulant present in a sample ( | 02-09-2012 |
20120037818 | SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIA FOR OBTAINING THREE-DIMENSIONAL INFORMATION FROM TWO-DIMENSIONAL FLUORESCENCE EMISSION DATA - Exemplary embodiments of a computer-accessible medium, method and system for providing information are provided. A first detection arrangement can be provided which can be configured to detect electro-magnetic radiations from a fluorescent particle(s) in a portion of a structure, and generate information associated with the portion of the structure. A second arrangement can be configured to generate a two-dimensional image and/or a three-dimensional image of the at least one portion of the structure as a function of the information. The electro-magnetic radiations can have different wavelengths. | 02-16-2012 |
20120043477 | Method for Detecting Drag Reducer Additives in Gasoline - A method for detecting polymer-based drag reducer additives in gasoline. One embodiment of the invention is a method for detecting the concentration of polymer-based drag reducer additives in gasoline, the method including the following: (a) placing a gasoline sample in a receptacle having at least two adjacent clear sides and irradiating one of the two clear sides of the receptacle with a pulsed laser beam, the pulsed laser beam having a wavelength in the ultra violet region shorter than 300 nm; (b) detecting laser-induced fluorescence wavelength resolved spectrum at 90° angle relative to the incident laser beam and through a slit defined in a diffraction screen, the diffraction screen being placed at a pre-defined first distance from the receptacle; (c) adjusting the position of the receptacle and slightly de-focusing the collimating lenses so that the low resolution fluorescence wavelength-resolved spectrum of the gasoline sample appears with a first peak at about 380 nm and a second peak at about 430 nm; (d) recording the laser-induced fluorescence wavelength-resolved spectra of the gasoline sample within a defined time-gate starting at the end of the temporal span of the laser pulse; and (e) comparing the percentage intensity of the first peak relative to the second peak for the laser-induced fluorescence spectrum near 380 nm of the gasoline sample to that of a gasoline sample free of any polymer-based drag reducer additives. In another embodiment of the method, the location of the diffraction-screen is at the pre-defined distance of between 0.5 mm to 2 mm from the side of the receptacle. In another embodiment of the method, the time-gate in step (d) is of 3 ns width and starting immediately after the end of the laser pulse. | 02-23-2012 |
20120043478 | Fluorescent Estimating Apparatus, Fluorescent Estimating Method, and Fluorescent Measuring Apparatus - This invention provides a technique for efficiently estimating spectral radiance factors of fluorescence of a sample. To this end, for a sample which contains a fluorescent substance, first spectral reflectance data and second spectral reflectance data are obtained by making two different variable-angle measurements using a general colorimeter under a white light source. Ratios n of the first spectral reflectance data to the second spectral reflectance data in a long-wavelength spectrum range outside a fluorescent spectrum range of the sample are calculated. Then, difference data between spectral reflectance data as results of multiplying the second spectral reflectance data by the ratios n, and the first spectral reflectance data are calculated. The difference data are divided by values obtained by subtracting 1 from the ratios n, thereby calculating spectral reflectances of fluorescence of the sample, that is, spectral radiance factors. | 02-23-2012 |
20120043479 | Normalization of Biomolecules - The present disclosure provides systems and methods for normalization of multiple samples, including DNA samples. The subject invention allows for decreased human error, decreased ergonomic concerns, and an increase in throughput. The subject invention provides systems and methods that allow for automated normalization of samples in multi-well plates. According to the present disclosure, a method for normalizing samples is provided. Some preferred methods comprise determining florescence data of one or more wells on a plate; electronically, using a processor, calculating dilution data for one or more of the wells on the plate based at least in part on the florescence data; and adding a liquid to the one or more wells on the plate based at least in part on the dilution data. | 02-23-2012 |
20120056103 | FLUORESCENCE INTENSITY COMPENSATION METHOD AND FLUORESCENCE INTENSITY COMPUTING APPARATUS - A fluorescence intensity compensation method includes emitting light onto microparticles multiply labeled with a plurality of fluorochromes having fluorescence wavelength ranges that overlap each other in order to excite the fluorochromes and receiving fluorescence generated by the excited fluorochromes using photodetectors having different reception wavelength ranges, and computing fluorescence intensities of the fluorochromes by compensating detection values of the photodetectors under a predetermined constraint condition imposed on the computed fluorescence intensities. | 03-08-2012 |
20120061586 | Method and detection system for detection of aflatoxin in corn with fluorescence spectra - A system and method for fluorescence spectral imaging of target material to detect the presence of a contaminant (such as aflatoxin in corn) is provided. An ultraviolet light source is coupled a light-excluding compartment. The fluorescence from the UV excited target passes through a filter (liquid crystal tunable, acoustic-optic tunable, a filter wheel, or other wavelength splitting device) and a lens, to a spectral imaging camera. Fluorescence spectral image data from the camera is analyzed by a computer and presented in human-readable form. Aflatoxin detection in contaminated corn kernels is based on peak fluorescence and peak fluorescence shift in the spectral range from 451 nm to 500 nm. Aflatoxin contamination level within the target material is quantified based on peak fluorescence and peak fluorescence shift and computed corn kernel pixel statistics. | 03-15-2012 |
20120061587 | DELAYED EMISSION DETECTION DEVICES AND METHODS - Embodiments of the present invention relate to a delayed emission detection device comprising a time-gated illumination source configured to provide excitation light to fluorophore during an excitation period and a light detector configured to receive emissions released from the fluorophore during a collection period after the excitation period. | 03-15-2012 |
20120061588 | FAECAL MARKERS - Described are methods for analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from an animal for the presence or absence of faecal matter. The methods comprise analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from the animal for the presence or absence of a detectable marker, the presence of the detectable marker being indicative of the presence of faecal matter and the absence of the detectable marker being indicative of the absence of faecal matter, wherein the animal carcass, meat obtained therefrom, or product produced by or obtained from the animal has been obtained from an animal fed a composition comprising a supplement of the detectable marker and/or a precursor thereof. Also described are compositions for feeding to an animal and for use in the methods. | 03-15-2012 |
20120061589 | METHOD AND APPARATUS FOR MEASURING FLUORESCENT MATERIAL IN A LIQUID - A method of measuring the amount of a fluorescent material in a liquid comprising the steps of exciting the fluorescent material and measuring the fluorescent response of the material over a range of wavelengths to determine a response spectrum, identifying the material from the response spectrum and determining the amount of material as a function of the amplitude of the fluorescent response and a calibration factor based upon the identification of the material. | 03-15-2012 |
20120061590 | SELECTIVE EXCITATION LIGHT FLUORESCENCE IMAGING METHODS AND APPARATUS - Imaging methods and apparatus may be applied to image tissues as well as other areas. A computer-controlled color-selectable light source is controlled to emit light having a desired spectral profile and to illuminate an area. An imaging detector images the illuminated area. The spectral profile may be selected to yield images in which contrast between features of interest and other features is enhanced. The images may be combined into a composite image. In some embodiments the spectral profile is based on a principal components analysis such that the images each correspond to one principal component. | 03-15-2012 |
20120080613 | Photolytically and Environmentally Stable Multilayer Structure for High Efficiency Electromagnetic Energy Conversion and Sustained Secondary Emission - A multilayer structure for sustained conversion of a primary electromagnetic radiation into another electromagnetic radiation characterized by a spectrum of a higher average wavelength is disclosed. Also disclosed are methods of creating and using the inventive multilayer structure. | 04-05-2012 |
20120080614 | PHOTOLYTICALLY AND ENVIRONMENTALLY STABLE MULTILAYER STRUCTURE FOR HIGH EFFICIENCY ELECTROMAGENTIC ENERGY CONVERSION AND SUSTAINED SECONDARY EMISSION - A multilayer structure for authentication that includes an energy conversion layer, at least one stability enhancement layer and at least one optical variable element is disclosed. Also disclosed are methods of creating and using the inventive multilayer structure for use-in authentication. | 04-05-2012 |
20120080615 | PHOTOLYTICALLY AND ENVIRONMENTALLY STABLE MULTILAYER STRUCTURE FOR HIGH EFFICIENCY ELECTROMAGENTIC ENERGY CONVERSION AND SUSTAINED SECONDARY EMISSION - A multilayer structure for use in authentication that includes an energy conversion, at least one stability enhancement layer and at least one blocking layer is disclosed. Also disclosed are methods of creating and using the inventive multilayer structure for use in authentication. | 04-05-2012 |
20120080616 | DEVICE AND METHOD FOR MULTI-PHOTON FLUORESCENCE MICROSCOPY FOR OBTAINING INFORMATION FROM BIOLOGICAL TISSUE - A device for multi-photon fluorescence microscopy for obtaining information from biological tissue is provided. The device comprising a laser unit for generating an excitation radiation, an optical unit which is formed to focus the excitation radiation for generating an optical signal at different locations in or on an object to be examined, and a detector module for detecting the optical signal from the region of the object. The optical unit for generating the optical signal at different locations in or on the object is movable in at least one direction relative to the object. | 04-05-2012 |
20120085930 | DETECTION METHOD - The present invention relates to a method for detecting the presence of a fungicide on a seed. In particular, the method according to the invention may be used to ensure that sufficient quantities of the fungicide or insecticide are present on the seed. In a particular embodiment the fungicide detected is thiabendazole. | 04-12-2012 |
20120085931 | FLUORESCING GEL FORMULATIONS AND THEIR APPLICATIONS - Fluorescing gel formulations are disclosed for monitoring cleaning of a surface. The fluorescing gel formulations are stable, fluoresce under UV light, and do not leave a mark after drying and removal. The compositions include an oppositely charged complexing agent which is used in combination with an anionic or cationic optical brightener. In some embodiments, the compositions include a cationic optical brightener with no complexing agent. | 04-12-2012 |
20120085932 | SYSTEMS AND METHODS FOR MULTISPECTRAL IMAGING | 04-12-2012 |
20120085933 | FLUORESCENCE DETECTION DEVICE AND FLUORESCENCE DETECTION METHOD - A fluorescence emitted by a measurement object at a measurement point is measured. When the fluorescence is measured, a measurement object is irradiated with laser light whose intensity is time-modulated by using a modulation signal at a predetermined frequency. Then, the fluorescence emitted by the measurement object is formed to a flux of the fluorescence having uniform distribution of light intensity, and a plurality of partial fluorescent signals are generated by receiving a plurality of divided portions of the flux of the fluorescence. At least some of the partial fluorescent signals are added altogether to generate a single fluorescent signal. Finally, a fluorescence relaxation time of the fluorescence emitted by the measurement object is calculated from the generated fluorescent signal by using the modulation signal. When fluorescence intensity of the fluorescence calculated from the fluorescent signal exceeds a predetermined threshold, the partial fluorescent signals to be added are limited in number. Thereby, an output power of the light-receiving unit can not be prevented from saturation. | 04-12-2012 |
20120091365 | ENHANCEMENT OF MOLECULAR EMISSION USING OPTICAL-ANTENNA STRUCTURES - The present disclosure relates to an apparatus, and methods of use, for enhancement of molecular emission by nano-antennas. Using the nano-antennas, the life-time is greatly shortened or the strength of broadly peaking spectral emission of fluorescent molecules is greatly enhanced by a generated electric field. The electric field generated is due to opposing charges located at two metallic end portions of the nano-antenna in response to receiving optical energy. | 04-19-2012 |
20120091366 | SYSTEM AND METHOD FOR THE MEASUREMENT OF MULTIPLE FLUORESCENCE EMISSIONS IN A FLOW CYTOMETRY SYSTEM - A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using Fourier Transform techniques. Systems and methods for the correction of inter-beam coincidence are also disclosed. | 04-19-2012 |
20120097865 | Luminescence Microscopy with Enhanced Resolution - The invention is directed to a resolution-enhanced luminescence microscopy method in which a sample is excited to the emission of luminescence radiation through irradiation by excitation radiation, and an image of the luminescing sample is acquired. A first partial volume of the sample is irradiated by a first laser radiation field of the excitation radiation, and a second partial volume of the sample is irradiated by a second laser radiation field of the excitation radiation. The first partial volume of the sample and the second partial volume of the sample overlap one another partially but not completely. Only the first laser radiation field is modulated with a first frequency, and luminescence radiation is detected from the first partial volume of the sample with modulation filtering so that luminescence radiation from the second partial volume of the sample is suppressed. | 04-26-2012 |
20120104280 | METHOD OF FLUORESCENT MEASUREMENT OF SAMPLES, AND DEVICES THEREFROM - The invention provides a method and device for fluorescent measurement of a sample. The method includes impinging an incident beam having an excitation wavelength and a focus diameter on the sample to yield a laser spot that defines sample volume. The laser spot is displaced relative to sample volume in three dimensional space defined by sample volume. The laser spot is translated across the sample volume in depth direction to detect one or more emitted fluorescence signals from the sample volume. A depth profile and a thickness of the sample carrier obtained from the one or more emitted fluorescence signals, are used for measuring normalized bulk fluorescence. Further, at least one microvolume of interest is obtained from the depth profile, and the incident beam is focused on the microvolume of interest to obtain at least one concentrated emitted fluorescence signal. | 05-03-2012 |
20120104281 | SYSTEM, METHOD, AND LUMINESCENT MARKER FOR IMPROVED DIFFUSE LUMINESCENT IMAGING OR TOMOGRAPHY IN SCATTERING MEDIA - A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously. | 05-03-2012 |
20120112095 | HIGH RESOLUTION MICROSCOPY USING AN OPTICALLY SWITCHABLE FLUOROPHORE - The invention relates to a method for high resolution visualization of a compound that can be switched by a switching signal from a state of low fluorescence to a state of higher fluorescence, and then revert to the state of low fluorescence. Said switching signal is directed to a spot in a region of a material containing said compound, and an optical signal adapted to lower the probability that said switching signal will successfully switch said compound to said state of higher fluorescence is directed to said spot and shaped to have a minimum in said spot, such that the probability that said switching signal successfully switches said compound is greatest at said minimum. Said spot containing both said switching signal and said optical signal is scanned over said region of said material while monitoring the fluorescence from said compound in said spot to create an image of said region. In some embodiments of the invention a plurality of spots are simultaneously scanned, to reduce the imaging time. | 05-10-2012 |
20120112096 | SYSTEM AND METHOD FOR DETERMINING THREE-DIMENSIONAL INFORMATION FROM PHOTOEMISSION INTENSITY DATA - A method and system for investigating properties of an object comprising: a transmitter, including a radiation source, the transmitter providing incident radiation having a plurality of predetermined polarization states; the incident radiation illuminating an object and thereby causing the object to emit photoemission; a receiver, receiving photoemission from the object when the object is illuminated by the incident radiation, the receiver including a detector, the detector providing photoemission intensity data; and signal processing circuitry, in electrical communication with the detector, the signal processing circuitry determining three-dimensional information relating to the object from the photoemission intensity data for each of the plurality of incident polarization states. | 05-10-2012 |
20120112097 | METHOD AND APPARATUS FOR QUANTITATIVE ANALYSIS OF THE EXTENT OF MEMBRANE FOULING BY USING FLUORESCENT PROTEIN STRUCTURES - Disclosed are a method and an apparatus for quantitative analysis of the extent of separation membrane fouling using a fluorescent protein structure, allowing easy quantitative analysis of the extent of separation membrane fouling and improving accuracy thereof. The disclosed method for quantitative analysis of the extent of separation membrane fouling using a fluorescent protein structure includes: preparing a solution containing a fluorescent protein structure; passing the solution containing the fluorescent protein structure through a separation membrane so as to adsorb the fluorescent protein structure onto the separation membrane; and quantitatively analyzing the fluorescent protein structure adsorbed onto the separation membrane by measuring fluorescence emitted by the fluorescent protein structure adsorbed to the separation membrane. | 05-10-2012 |
20120112098 | ENHANCING VISUAL ASSESSMENT OF SAMPLES - Methods and systems for imaging a biological sample are disclosed, and include: (a) staining the sample with a first stain that includes eosin and at least one additional stain; (b) directing excitation light to the sample to cause each of the stains to emit fluorescence; and (c) recording images of the fluorescence emitted from the stains in the sample, where the amount of eosin in the sample is sufficiently dilute to cause the sample to have an average optical density of less than 0.10 at green wavelengths. | 05-10-2012 |
20120119110 | APPARATUS, AND ASSOCIATED METHOD, FOR DETECTING CONTAMINATION OF AN OBJECT - An apparatus, and an associated method, for a portable electronic device, such as a wireless device, to determine luminescence of an object of interest. Ultraviolet A (UVA), or other appropriate, light energy is cause to be generated at a flicker rate. Images of the object of interest are recorded both when the UVA light energy is incident on the object of interest and in the absence of incidence of the UVA light energy on the object of interest. The images are compared, and a determination is made of the luminescence of the object of interest. | 05-17-2012 |
20120119111 | METHOD AND APPARATUS FOR READING OUT IMAGE INFORMATION STORED IN A STORAGE PHOSPHOR OF A STORAGE MEDIUM - A method for reading out image information stored in a storage phosphor of a storage medium includes moving a light beam over the storage medium. A luminescence signal is generated by the photostimulation of the storage phosphor. In first time intervals a respective output value is determined from the luminescence signal, and a respective pixel value of an image pixel of a digital image is determined from the output value. The output value is thereby determined by addition of a plurality of measurement values of the luminescence signal which are detected in second time intervals lying within the first time interval. A corresponding apparatus for carrying out the method is described as well. | 05-17-2012 |
20120126141 | SURFACE COATING FOR INSPECTION - A method of inspecting an article, comprising applying an organic liquid substance over at least a portion of the article to be inspected so as to form a surface layer thereon, wherein said surface layer is luminescent. The article is irradiated with the surface layer thereon; and, scanning the article to determine its shape. | 05-24-2012 |
20120126142 | FLUORESCENT ANALYSIS METHOD - Disclosed is a fluorescent analysis method whereby the throughput in DNA sequence analysis or the like can be improved. The method comprises irradiating a substrate, which carries biological molecules such as oligonucleotides immobilized thereon, with light for fluorescent measuring, collecting the generated fluorescence, dispersing the collected light, forming an image by focusing the light on a two-dimensional sensor, and then detecting the fluorescence with the two-dimensional sensor. In this method, since wavelengths are dispersed in different directions and then detected at the same time, the intensity of each dispersed wavelength and the position of the subject of spectroscopic imaging can be calculated even in the case where the wavelength dispersion distance is longer than the inter-lattice distance. | 05-24-2012 |
20120126143 | APPARATUS AND METHOD FOR OPERATING OPTICAL MICROCAVITY BY LIGHT EMITTING DIODE - An optical cavity mode apparatus comprising at least one microresonator; a light emitting diode for supplying light irradiation to the microresonator to stimulate the excitation level of the microresonator; and an optical detector to obtain spectra of the microresonator stimulated by the light emitting diode. | 05-24-2012 |
20120138820 | System and method for detecting and visualizing ignitable liquid residues using hyperspectral imaging - The present disclosure provides for a system and method for detecting, identifying and/or distinguishing between ignitable liquid residues on various types of substrates. A method may comprise generating a fluorescence data set representative of a substrate, which may comprise a fluorescence hyperspectral image. This fluorescence data set may be analyzed to determine the presence and/or identity of an ignitable liquid residue. Regions of a substrate comprising an ignitable liquid residue may further be interrogated using Raman techniques. This may comprise generating and analyzing a Raman data set representative of a region of interest of a substrate to thereby identify an ignitable liquid residue. A system may comprise an illumination source, a tunable filter, and a first detector configured to generate a fluorescence data set. The system may further comprise a second detector configured to generate a Raman data set representative of a region of interest of a substrate. | 06-07-2012 |
20120145924 | FLUORESCENCE EMISSIONS DETECTOR - A light source is gated ON and OFF in response to a pulsed signal. Photo emissions from the light source are coupled to a material under test. Resonant fluorescent emissions from the material are coupled to a photodiode. Current from the photodiode is coupled into an amplifier system comprising a first and second amplifier stages. The first amplifier stage is gated to a low gain when the light source is turned ON and the gain is increased when the light source goes from ON to OFF. The second amplifier stage has digitally programmable offset and gain settings in response to control signals. The output of the second amplifier stage is digitized by an analog to digital converter. A controller generates the pulse control signal and the control signals. | 06-14-2012 |
20120145925 | PHOTOFRAGMENTATION-LASER-INDUCED FLUORESCENCE FOR DETECTION OF NITRIC OXIDE-BEARING EXPLOSIVES - A method for identifying a presence of a nitro (NO)-bearing compound suspected of being included in a sample includes photodissociating a sample into one or more fragments that include a NO molecule, where the NO molecule has an electron in a first-vibrational excited state of an electronic ground state. Laser-induced fluorescence (LIF) is applied including directing UV light from a UV laser source at the sample to induce fluorescent light. An emission wavelength of 270 nm to 274 nm from fluorescent light received is used to identify a presence of the NO-bearing compound in the sample. | 06-14-2012 |
20120145926 | 3D IMAGING OF LIVE CELLS WITH ULTRAVIOLET RADIATION - A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell. | 06-14-2012 |
20120153187 | METHOD FOR LOCATING AN OPTICAL MARKER IN A DIFFUSING MEDIUM - A method is disclosed for locating at least one optical marker in a diffusing medium, said marker having at least one optical property different from the diffusing medium, method wherein:
| 06-21-2012 |
20120161035 | Method of classifying microorganisms using UV irradiation and excitation fluorescence - A method and device for detecting, differentiating from background and providing partial identification (i.e., classification) for biological particles found in aerosols or surface dust. The method is based on the phenomenon that luminescent excitation-emission (EEM) graphs of microorganisms obtained before and after perturbation by irradiation with ultraviolet light show characteristic patterns which differ according to the type of particle. For example, | 06-28-2012 |
20120168643 | LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs. | 07-05-2012 |
20120168644 | CONFOCAL IMAGING METHODS AND APPARATUS - The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis. | 07-05-2012 |
20120175528 | PARTICULATE COMPOSITIONS HAVING PLURAL RESPONSES TO EXCITATION RADIATION - A particulate composition comprises a plurality of particles wherein at least one of the particles comprises at least two different crystalline and/or glass phases, each phase comprising a host lattice and a dopant sensitive to electromagnetic radiation. The different phases simultaneously produce different responses on exposure to photons of the same energy, whereby the output from the particulate composition when exposed to said photons is the sum of the responses from the different phases. | 07-12-2012 |
20120181449 | SYSTEM AND METHOD FOR VERIFYING CORRECT ORDERING OF STACK OF COMPONENTS - A method of determining whether a stack of components in a device are in a desired order includes irradiating each of the components in the device with an energy beam. The radiation emissions from each of the irradiated components are detected with a radiation detector. The detected radiation emissions are analyzed using a central processing unit (CPU) to determine whether the components in the device are stacked in the desired order. | 07-19-2012 |
20120181450 | METHOD AND APPARATUS FOR DETECTING BIO MATERIAL USING PHOTOELECTRIC CONVERSION DEVICE, AND METHOD FOR MANUFACTURING PHOTOELECTRIC CONVERSION DEVICE - An apparatus for detecting a bio material includes: an conjugate of a bio material and a fluorescent material to be excited and emit light of a lower energy than an energy of incident light by virtue of the fluorescent material when the light is incident; and an optical filter for allowing the excitation-emitted light from the conjugate, among the incident light, to be transmitted therethrough. The apparatus further includes a photoelectric conversion device for converting the light transmitted through the optical filter into an electric signal. | 07-19-2012 |
20120181451 | Waveguide-based Sensor - A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region. | 07-19-2012 |
20120181452 | SEPARATION OF DOPING DENSITY AND MINORITY CARRIER LIFETIME IN PHOTOLUMINESCENCE MEASUREMENTS ON SEMICONDUCTOR MATERIALS - Methods are presented for separating the effects of background doping density and effective minority carrier lifetime on photoluminescence (PL) generated from semiconductor materials. In one embodiment the background doping density is measured by another technique, enabling PL measurements to be analysed in terms of effective minority carrier lifetime. In another embodiment the effective lifetime is measured by another technique, enabling PL measurements to be analysed in terms of background doping density. In yet another embodiment, the effect of background doping density is removed by calculating intensity ratios of two PL measurements obtained in different spectral regions, or generated by different excitation wavelengths. The methods are particularly useful for bulk samples such as bricks or ingots of silicon, where information can be obtained over a much wider range of bulk lifetime values than is possible with thin, surface-limited samples such as silicon wafers. The methods may find application in solar cell manufacturing for improving the manufacture of silicon ingots and bricks, or for providing a cutting guide for wafering. | 07-19-2012 |
20120193552 | FLUORESCENCE LIFETIME IMAGING - A method of measuring fluorescence from a location, the method comprising applying to the location a first fluorescence excitation signal having a first duty cycle, accumulating as a first result fluorescence that emanates from the location in response to the first excitation signal, applying to the location a second fluorescence excitation signal having a second duty cycle, accumulating as a second result fluorescence that emanates from the location in response to the second excitation signal, and comparing the first and second results to provide a comparison result for the location. The invention also relates to apparatus for performing the method. | 08-02-2012 |
20120205553 | PHOTOLUMINESCENT MARKINGS WITH FUNCTIONAL OVERLAYERS - A photoluminescent marking that includes a photoluminescent layer and at least one functional overlayer is disclosed. The photoluminescent layer comprises at least one type of photoluminescent material. The at least one functional overlayer is adapted to selectively filter wavelengths of radiation to enhance the daylight observability of a final emission signature of the marking or to prevent the observability with the naked eye of a printed message on the marking. Also methods of making and using the inventive photoluminescent marking are disclosed. | 08-16-2012 |
20120205554 | AIR-STABLE, BLUE LIGHT EMITTING CHEMICAL COMPOUNDS - We report the synthesis and characterization of four novel CCC—NHC pincer platinum(II) and palladium(II) complexes, which adopt a distorted square planar configuration. These complexes emit bright blue light in the solid state under UV irradiation with emissions that are stable in ambient atmosphere (O2 and H2O) for extended periods. We also report the synthesis and characterization of CCC—NHC pincer ligand nickel complexes, and solid state fluorescence spectra have been collected for two of the complexes reported. X-ray structural analysis of a representative compound exhibits a distorted square planar geometry. Finally, we report the synthesis and characterization of CCC—NHC pincer ligand complexes for abnormal carbens, triazole, and BIA. | 08-16-2012 |
20120211670 | Systems and Methods of Detecting Force and Stress Using Tetrapod Nanocrystal - Systems and methods of detecting force on the nanoscale are provided. The described invention includes methods for detecting force using a tetrapod nanocrystal by exposing the tetrapod nanocrystal to light, which produces a luminescent response by the tetrapod nanocrystal. The method continues with detecting a difference in the luminescent response by the tetrapod nanocrystal relative to a base luminescent response that indicates a force between a first and second medium or stresses or strains experienced within a material. Such systems and methods find use with biological systems to measure forces in biological events or interactions. | 08-23-2012 |
20120211671 | DEVICE AND METHOD FOR SPATIAL RECONSTRUCTING OF ABSORBERS MAPPING - The invention concerns a method for locating at least one absorber in a diffusing medium, using at least one excitation radiation and at least one detector (Φ | 08-23-2012 |
20120217416 | BANKNOTE VALIDATOR - The present invention relates to the technical field of devices for reading/authenticating banknotes. The invention also concerns handheld devices, particularly those which may be used by visually impaired persons, to identify different banknote denominations. The present invention is aimed at providing a banknote validator that avoids the drawbacks of the prior art. The validator according to the invention may as well be used for validating a security document including a marking (like luminescent ink or pattern printed on said document, luminescent security thread or strip, for example) operable to glow with a specific color luminescence under appropriate UV light illumination. The invention further describes a method for identifying a denomination of a banknote having a test zone including a marking operable to glow with a specific color luminescence according to the denomination under appropriate UV light illumination. | 08-30-2012 |
20120223251 | Analyte Detector and Method - Instrument and method for detecting pesticides and other analytes. A sample to be tested is mounted on a cassette and inserted into a housing which is substantially impervious to light, and light from a source within the housing is directed toward the sample to induce fluorescent emission from analyte on the sample. Fluorescent emissions from the sample are monitored with a detector within the housing to detect emissions having a spectral content characteristic of the analyte to be detected. Data from the detector is processed, and information based on the processed data is displayed. In some embodiments, the instrument is calibrated with data from a reference sample of known concentration or density. The detector measures the analyte in units of mass per unit area, and in some embodiments the mass per unit area is converted to units of concentration or density of the analyte in the sample. | 09-06-2012 |
20120228519 | System and Method for Fluorescence and Absorbance Analysis - A system or method for analyzing a sample include an input light source, a double subtractive monochromator positioned to receive light from the input light source and to sequentially illuminate the sample with each of a plurality of wavelengths, a multi-channel fluorescence detector positioned to receive and substantially simultaneously detect multiple wavelengths of light emitted by the sample for each of the plurality of excitation wavelengths, an absorption detector positioned to receive and detect light passing through the sample, and a computer in communication with the monochromator, the fluorescence detector, and the absorption detector, the computer controlling the monochromator to sequentially illuminate the sample with each of the plurality of wavelengths while measuring absorption and fluorescence of the sample based on signals received from the fluorescence and absorption detectors | 09-13-2012 |
20120235061 | LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs. | 09-20-2012 |
20120241646 | POLYMER-CONJUGATED QUANTUM DOTS AND METHODS OF MAKING THE SAME - The present application relates to polymer-conjugated quantum dots. The quantum dots can include, for example, an inorganic core conjugated to a polymer. The quantum dots may, in some embodiments, be water-soluble and exhibit superior photoluminescence. Also disclosed are methods of making and using the quantum dots. | 09-27-2012 |
20120241647 | MULTIPHOTON LUMINESCENCE IMAGING OF PROTEIN CRYSTALS - A method for detecting protein crystals comprises: illuminating a sample with a laser to produce multiphoton excitation; collecting an emission spectrum; and determining whether the sample comprises protein crystals. | 09-27-2012 |
20120248334 | Refractive Index Matching In Capillary Illumination - System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. | 10-04-2012 |
20120248335 | METHOD AND APPARATUS FOR INSPECTING SOLAR CELL - Disclosed herein are a method and an apparatus for inspecting solar cells. According to an exemplary embodiment of the present invention, a method for inspecting solar cells includes: (a) preparing solar cells; (b) obtaining a photoluminescence image(s) by irradiating light to the prepared solar cells; and (c) determining a conversion efficiency rating of each solar cell according to brightness of the obtained image. Further, an apparatus for inspecting solar cells includes a stage unit that transfers solar cells; a light source unit that irradiates light to a surface of the solar cell transferred through the stage unit; a camera unit that obtains a photoluminescence image according to the light irradiated from the light source unit; and an efficiency determination unit that determines a conversion efficiency rating of each solar cell based on brightness of an image obtained from the camera unit according to preset programs. | 10-04-2012 |
20120248336 | Apparatus and Method for Batch Non-Contact Material Characterization - An apparatus for performing non-contact material characterization includes a wafer carrier adapted to hold a plurality of substrates and a material characterization device, such as a device for performing photoluminescence spectroscopy. The apparatus is adapted to perform non-contact material characterization on at least a portion of the wafer carrier, including the substrates disposed thereon. | 10-04-2012 |
20120248337 | PHOSPHORESCENT ORGANIC COMPOUNDS - Compositions providing metal-independent phosphorescence due to a directed heavy atom effect are provided. Methods of providing a phosphorescent composition are also provided where a directed heavy atom effect is maintained to cause the composition to be phosphorescent. Manufacture of phosphorescent compositions using intermolecular and intramolecular directed heavy atom effects are disclosed. | 10-04-2012 |
20120256101 | SUPER-RESOLUTION MICROSCOPY SYSTEM USING SPECKLE ILLUMINATION AND ARRAY SIGNAL PROCESSING - A nano-scale resolution fluorescence microscopy system and a method of obtaining an image using the nano-scale resolution microscopy system, and more particularly, a method and a microscopy system, capable of observing fluorescence probes in high resolution by radiating an irregular diffused light to have an incoherent speckle pattern that has low correlation in an adjacent space are disclosed. According to embodiments of the present invention, a diffraction limit of a fluorescence microscope may be overcome, and a super high resolution image on a nanometer scale may be obtained. | 10-11-2012 |
20120256102 | Dye-conjugated dendrimers - The invention provides dendrimers, conjugates thereof, and methods of using dendrimer conjugates. In one embodiment, the invention provides novel polymeric dendrimers as a new class of fluorescent labels. The labels can include multiple fluorescent dye molecules conjugated to a single polymeric backbone or core, such as a dendrimer. The dendrimers can have regular or irregular branched polymeric network structures that allow for the chemical attachment of multiple dye molecules, multiple color dyes, and/or multiple functional groups, in a combinatorial fashion. The fluorescent dendritic nanoprobes (FDNs) thus provide a new class of fluorescent reporters for fluorescence microscopy and imaging. | 10-11-2012 |
20120261591 | DEVICE AND METHOD FOR DETERMINING THE CONCENTRATION OF FLUOROPHORES IN A SAMPLE | 10-18-2012 |
20120273695 | HIGH RESOLUTION FLUORESCENCE DETECTION SYSTEM - A compact image sensor for imaging radiation emitted by fluorescing objects exposed to excitation light is disclosed. The compact image sensor includes a light guide defining a longitudinal axis for channeling radiation emitted by the fluorescing object; a reflective surface defined on the light guide that is oriented at an angle with respect to the longitudinal axis of the light guide to reflect the excitation light away from a detector of the image sensor; and the detector positioned at an end of the light guide for imaging radiation emitted by the fluorescing object. Also disclosed is a fluorescence imaging system for imaging radiation emitted by a fluorescing object to be imaged by compact image sensor and a method of fluorescence imaging. | 11-01-2012 |
20120273696 | Compositions Having Multiple Responses to Excitation Radiation and Methods for Making Same - The present invention relates to a composition having a first response to a first electromagnetic radiation and, after intermediate exposure to a second electromagnetic radiation, a second response to the first electromagnetic radiation, different from the first response. In one aspect, the composition exhibits a regenerated first response to the first electromagnetic radiation after exposure to a third electromagnetic radiation. | 11-01-2012 |
20120280145 | OLIGOFLUORANTHENES AND METHODS AND APPARATUSES FOR DETECTING NITROAROMATICS USING THE SAME - The present application relates to compositions having at least one oligofluoranthene. The compositions may, for example, emit blue or green light when exposed to a blue or ultraviolet radiation. Methods of making the compositions are also disclosed, as well as methods and apparatuses for producing light and detecting nitroaromatics using the compositions. | 11-08-2012 |
20120280146 | METHOD AND SPECTROSCOPIC ANALYSIS APPLIANCE, ESPECIALLY FOR ANALYSING FOOD, WITH MULTI-CHANNEL TREATMENT OF SPECTRAL DATA - The invention relates to a method for the spectroscopic analysis of at least one sample, using a method for analysing spectroscopic data based on a multi-channel statistical model, said method comprising: the illumination of said or each sample to be analysed by a plurality of luminous excitation rays with respective wavelengths; the acquisition and the pre-treatment of frontal fluorescence spectra, each spectrum corresponding to a respective luminous excitation ray; for each sample, the calculation of a score vector by applying said multi-channel statistical model to the pre-treated spectra; and the determination of at least one parameter selected from a quality indicator of said or each sample and a parameter characterising a method that has been applied to said or each sample, from said score vector; the method being characterised in that the average spectral distance between the luminous excitation rays is at least 50 nm, over a spectral range of at least 100 nm. The invention also relates to an appliance for implementing such a method. | 11-08-2012 |
20120286171 | FLUORESCENCE MEASURING APPARATUS AND FLUORESCENCE MEASURING METHOD - Disclosed herein is a fluorescence measuring apparatus capable of determining whether accuracy of measuring fluorescence lifetime is deteriorated or not due to adjustment of the apparatus. The fluorescence measuring apparatus for measuring fluorescence emitted when an objects to be measured are irradiated with laser light includes: a laser light source that irradiates each of the objects to be measured with intensity-modulated laser light; a light-receiving unit that receives fluorescence emitted when each of the objects to be measured is irradiated with the laser light; a signal processing unit that determines a fluorescence lifetime using a signal of the fluorescence received by the light-receiving unit; and a determining unit that determines whether or not a fluorescence lifetime dispersion of the objects caused by amplification of the signal of the fluorescence performed by the light-receiving unit or by the signal processing unit is larger than a predetermined value. | 11-15-2012 |
20120292531 | Optical Sources - An optical source ( | 11-22-2012 |
20120292532 | DOSIMETRY SYSTEM BASED ON OPTICALLY STIMULATED LUMINESENCE - Methods for detecting exposure to ionizing radiation are provided. In particular, methods for detecting and measuring the exposure of keratin-rich materials to ionizing radiation using optically stimulated luminescence are provided. | 11-22-2012 |
20120298885 | FLUOROMETRIC ASSAY APPARATUS AND FLUOROMETRIC ASSAY METHOD - A fluorometric assay apparatus comprising an LED light source configured with at least two types of excitation LED that have different principle wavelengths from each other and are disposed in a two dimensional array on a substrate; an imaging lens for imaging a subject; a single excitation filter provided between the LED light source and a subject, the single excitation filter transmitting each of principle wavelength components of the LED light source; and a single detection long pass filter provided between the imaging lens and the subject. | 11-29-2012 |
20120305802 | Nanoparticles and Methods of Generating Coherent Emission Therefrom - Nanoparticles with a metal or metallic core and an outer shell comprising a matrix and a dopant. For example, a nanoparticle can have a gold core and outer shell comprising silica and an organic dye. Such nanoparticles can have use in, for example, optical communication applications, chemical and biosensing applications, and imaging applications. | 12-06-2012 |
20120305803 | METHOD AND DEVICE FOR SETTING A SUITABLE EVALUATION PARAMETER FOR A FLUORESCENCE MICROSCOPE - A method for setting an evaluation parameter for a fluorescence microscope includes exciting dye particles in a sample to fluoresce and detecting fluorescent light from the particles. A graphical representation of a distribution of the fluorescent light is determined and a signal is generated for use in displaying the graphical representation on a display unit. Each subregion of the graphical representation is associated with a comparison value that is representative of a light quantity in the subregion. A predefined threshold is used as an evaluation parameter and compared to the comparison values. The subregions having a comparison value that is greater than the threshold value are marked on the display unit with predefined markings. The threshold value is changed and the comparison values are compared to the changed threshold value. The marked regions are defined as events and a complete image of the sample is obtained based on the events. | 12-06-2012 |
20120313009 | Optical Detection System - An optical detection system includes a sample carrier receiving region that receives a sample carrier carrying a sample. The system further includes a source that emits an excitation signal having a wavelength within a predetermined wavelength range. The excitation signal illuminates the sample carrier. A first sub-portion of the excitation signal is absorbed by the sample, which emits characteristic radiation in response thereto. A second sub-portion of the excitation signal traverses the sample carrier. The system further includes a detector that detects the characteristic radiation. The system further includes an absorber that absorbs the excitation signal traversing the sample carrier without being absorbed by the sample or sample carrier. The absorber absorbs at least 95% of the excitation signal traversing the sample carrier. | 12-13-2012 |
20120313010 | System and Method for Automatically Determining Optimal Excitation and Emission Wavelengths of a Fluorophore - A system for performing spectrofluorometry of a fluorophore sample is provided. The system includes an input module that receives user input corresponding to spectrofluorometer settings. A control module transmits control signals for controlling the spectrofluorometer during respective wavelength scans of a fluorophore sample and a blank sample. The control signals provide for automatic execution of the wavelength scans over an excitation wavelength range and an emission wavelength range. A signal-to-background determination module automatically determines multiple signal-to-background ratios based on fluorescence measurements of the fluorophore sample and the blank sample received from the spectrofluorometer. A signal-to-background analysis module automatically determines the maximum signal-to-background ratio from the multiple signal-to-background ratios. | 12-13-2012 |
20120313011 | METHOD OF MEASURING LUMINESCENCE OF A MATERIAL - A method of measuring luminescence of a material is disclosed. The method includes applying a light source to excite an exposed material. The method also includes amplifying an emission signal of the material. The method further includes measuring a luminescent emission at a fixed time window of about 10 picoseconds to about 10 nanoseconds. The luminescence may be radio photoluminescence (RPL) or optically stimulated luminescence (OSL). | 12-13-2012 |
20120313012 | Photobleaching and Intermittency Localization Microscopy - A method of image analysis creates super-resolution images from images with high densities of fluorophores by processing a movie in which the fluorescent molecules or particles are photobleaching or blinking. The method looks for the individual photobleaching events that can be located with high resolution (nm to tens of nanometers scale). The positions of the photobleaching or blinking events are then drawn in a composite image that is at a much higher resolution than the original fluorescence movie. | 12-13-2012 |
20120319007 | LUMINESCENCE MICROSCOPY - A luminescence microscopy method includes a sample being used, which comprises a certain substance, wherein the certain substance can be converted repeatedly from a first state, in which it can be excited into emitting luminescence radiation, into a second state, in which it cannot be excited into emitting luminescence radiation. The substance present in the sample can be brought into the first state by irradiating switch radiation. The certain substance can be excited into emitting luminescence radiation by irradiating excitation radiation. The sample emitting luminescence radiation can be displayed. A high-resolution selection of sample regions extending perpendicularly to a sample surface is carried out by irradiating either the switch radiation or the excitation radiation as structured illumination of the sample. A high-resolution selection of the sample surface is carried out by irradiating the switch radiation and/or the excitation radiation as TIRF illumination of the sample. | 12-20-2012 |
20120319008 | Signal Noise Reduction for Imaging in Biological Analysis - A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings. | 12-20-2012 |
20120319009 | OPTICAL ANALYSIS DEVICE, OPTICAL ANALYSIS METHOD AND COMPUTER PROGRAM FOR OPTICAL ANALYSIS - The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, computes a characteristic value of the light intensity indicating the presence or absence of the light from a single light-emitting particle in every time section of a predetermined width in the light intensity data; and detects the light-emitting particle crossing the inside of the micro region individually using the characteristic value, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle. | 12-20-2012 |
20120326054 | In Situ Photoluminescence Characterization System and Method - A workpiece characterization system for measurement of photoluminescence and/or layer properties of a workpiece. The workpiece characterization system includes an excitation light impinging upon a surface of a workpiece whereby the workpiece emits photoluminescent light. The emitted photoluminescent light may be characterized and correlated for determination of workpiece parameters such as dopant concentrations and LED performance characteristics. Additionally, the workpiece characterization system may also include an illumination impinging upon a surface of said workpiece whereby the illumination source is encoded with layer information from said workpiece. One or both of the lights are selectively collected, and each collected light is angularly and spatially sampled. Layer properties and/or photoluminescence properties of said workpiece may be measured from the selectively collected, and angularly and spatially sampled lights. | 12-27-2012 |
20120326055 | SYSTEM AND METHOD FOR SUB-SURFACE FLUORESCENCE IMAGING - A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography. | 12-27-2012 |
20120326056 | GLASS SUBSTRATE LIGHT EMITTING ELEMENT AND METHODS FOR MANUFACTURING AND LUMINESCENCE THEREOF - A light emitting element ( | 12-27-2012 |
20130001436 | SUB-DIFFRACTION IMAGE RESOLUTION AND OTHER IMAGING TECHNIQUES - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like. | 01-03-2013 |
20130015367 | Wavefront Correction of Light Beam - An apparatus includes a transverse scanning optical system in the path of a first light beam traveling along a first optic axis; a wavefront correction system in the path of a second light beam traveling along a second optic axis, the wavefront correction system including a wavefront correction device having a spatial phase profile on its surface; a beam combiner that receives the first light beam and the second light beam and outputs an interference beam having a beat frequency equal to a difference frequency between the first light beam and second light beam; and a detection system placed relative to a random scattering medium, which is in the path of the interference beam. The detection system detects measurement light produced by the random scattering medium while the interference beam strikes the random scattering medium. | 01-17-2013 |
20130015368 | INSPECTION APPARATUS AND INSPECTION METHODAANM NAKANISHI; HidetoshiAACI Kyoto-shiAACO JPAAGP NAKANISHI; Hidetoshi Kyoto-shi JPAANM TONOUCHI; MasayoshiAACI Suita-shiAACO JPAAGP TONOUCHI; Masayoshi Suita-shi JPAANM KAWAYAMA; IwaoAACI Suita-shiAACO JPAAGP KAWAYAMA; Iwao Suita-shi JP - A technology of inspecting a photoexcited carrier generation area of a photo device in a non-contact manner is provided. An inspection apparatus inspects a photovoltaic cell panel in which the photo device is formed. The inspection apparatus includes an irradiation part that irradiates the photovoltaic cell panel with pulsed light from a light receiving surface side and a detecting part (detector) that detects electric field intensity of a terahertz wave pulse, which is generated according to the irradiation of the pulsed light. | 01-17-2013 |
20130015369 | METHODS AND APPARATUS FOR AUTHENTICATING ARTICLES WITH LUMINESCENT PHOSPHOR COMPOUNDS - Methods and apparatus for article authentication include an exciting radiation generator that exposes an area of the article to exciting radiation, and at least two radiation detectors that detect emitted radiation from the area in a first band and in a second band that does not overlap the first band. The first band corresponds with a first emission sub-band of an emitting ion, and the second band corresponds with a second emission sub-band of the same emitting ion. A processing system calculates a comparison value that represents a mathematical relationship (e.g., a ratio) between a first intensity of the emitted radiation in the first band with a second intensity of the emitted radiation in the second band, and determines whether the comparison value compares favorably with an authentication parameter. When the comparison value compares favorably with the authentication parameter, the article is identified as being authentic. | 01-17-2013 |
20130015370 | CONFOCAL FLUORESCENCE SLIDE SCANNER WITH PARALLEL DETECTION - An instrument and method for scanning a large specimen supported on a specimen holder has a plurality of illumination sources with each illumination, source being focused on a different focus spot of the specimen simultaneously. There are a plurality of spectrally resolved detectors to receive light reflected or emitted from the different focus spots simultaneously with each spectrally resolved detector receiving light from one illumination source only. | 01-17-2013 |
20130020503 | METAL ENHANCED FLUORESCENCE FROM METALLIC NANOBURGER STRUCTURES - The present invention provides for metallic nanostructures or nanoburgers comprising a dielectric layer positioned between metallic layers and their use in metal enhanced emissions systems to enhance emissions from fluorophores, including intrinsic and extrinsic; luminophores; bioluminescent species and/or chemiluminescent species. The multilayer nanoburgers exhibit several distinctive properties including significantly enhanced intensity of emissions, decreased lifetime and increased photostability by simply varying the thickness of the dielectric layer while maintaining a constant thickness of the two metallic layers on opposite sides of the dielectric layer. | 01-24-2013 |
20130020504 | METHOD AND DEVICE FOR IDENTIFYING A PHOTOLUMINESCENT MATERIAL - A method for identifying a photoluminescent material that, after excitation with excitation light, emits emission light having different wavelengths is disclosed. The method includes irradiating the photoluminescent material with the excitation light, detecting a temporal intensity curve of at least two emission light components having different wavelengths, which components are emitted from the photoluminescent material as a result of the excitation, calculating initial intensities of the emission light components at a common time, determining at least one intensity parameter by correlating the calculated initial intensities, determining at least one decay parameter value for each of the emission light components from a time progression of their intensity and identifying the photoluminescent material using the intensity parameter(s) and the decay parameter values. A device configured to identify the photoluminescent material includes an excitation light source, a receiving apparatus, an evaluation apparatus and a control apparatus that performs the photoluminescent material identifying method. | 01-24-2013 |
20130020505 | System And Method For Evaluating Material In Rotary Motion - Systems and methods evaluate material in rotary motion. Exposure duration is calculated based upon an intensity of radiation incident upon a sample area of the material and a desired radiation exposure for the material. Angular velocity for a rotational stage is calculated based upon the sample area, the calculated exposure duration, and an initial position of a linear stage. The initial position of the linear stage, the initial velocity of the linear stage, and the initial angular velocity of the rotational stage are set and a radiation generator is activated. The system then waits for time to read the next data sample based upon the calculated exposure duration and a fluorescence level of the material is determined. Angular velocity of the rotational stage and linear velocity of the linear stage are controlled based upon positional sensors to capture data from all areas of the material at the desired radiation exposure. | 01-24-2013 |
20130020506 | Fluorescence Meter - A fluorescence meter for analyzing a sample, comprising a main beam path and at least one optical module. The fluorescence meter is embodied so as to provide at least one electromagnetic beam for exciting the sample and receive at least one electromagnetic beam emitted by the sample, at least some sections of at least two of the electromagnetic beams being located on one plane while extending along the main beam path. | 01-24-2013 |
20130020507 | Methods for Detecting Defects in Inorganic-Coated Polymer Surfaces - Lipophilic fluorescent substances can be used to detect surface defects in materials having hydrophilic (e.g., inorganic) coatings. Use of the described methods makes surface defects appear fluorescent, while the remaining surfaces are not labeled. The disclosed methods are inexpensive, rapid, and easy alternatives to existing approaches. | 01-24-2013 |
20130026391 | INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, PROGRAM, AND METHOD OF CORRECTING INTENSITY OF FLUORESCENCE SPECTRUM - Provided is an information processing apparatus including an estimation unit that expresses a light intensity distribution, which is obtained by irradiating light to a measurement object of a measurement target having a plurality of substances with mutually different responsive characteristics to the light on a surface and/or an inside of the measurement object, as a linear combination of light intensity distributions, which are obtained by irradiating the light to reference measurement objects, each of which has a single substance, models the light intensity distribution obtained from each of the reference measurement objects so as to follow a predetermined probability distribution, and estimates a combination coefficient of the linear combination from the light intensity distribution obtained from the measurement object of the measurement target. | 01-31-2013 |
20130037728 | PARTICLE ANALYZER WITH SPATIAL MODULATION AND LONG LIFETIME BIOPROBES - An analyzer includes a flow cell having a flow channel through which a sample passes. A light source excites at least a first particle type in the sample in one or more excitation region(s), and a detector detects light emitted by the excited particle. A spatial filter defines detection regions, wherein light emitted by the particle is transmitted to the detector, and interspersed shielded regions, wherein such light is at least partially blocked from reaching the detector. The light emitted by the excited particle has a response time τ | 02-14-2013 |
20130037729 | Determining the Distribution of a Substance by Scanning with a Measuring Front - For determining the distribution of a substance, a measuring front is formed of a first and a second optical signal. Intensities of the first and second optical signals, over a depth of the measuring front which is smaller than the diffraction limit at the wavelengths of the first and second optical signals, increase so steeply that a portion of the substance in a measurement state in which a measurement signal is available from the substance increases from essentially zero due to transferring the substance by means of the first optical signal into the measurement state, and decreases to essentially zero again due to transferring the substance by means of the second optical signal back out of the measurement state. The measuring front is moved over a measurement region. The measurement signal is recorded for different positions of the measuring front in the measurement region and assigned to these positions. | 02-14-2013 |
20130043405 | In-Line Photoluminescence Imaging of Semiconductor Devices - Methods and systems are presented for acquiring photoluminescence images ( | 02-21-2013 |
20130043406 | LUMINESCENT COMPOUNDS - A crystalline phosphor of formula: | 02-21-2013 |
20130043407 | Zn5(BTA)6(TDA)2 - A ROBUST HIGHLY INTERPENETRATED METAL-ORGANIC FRAMEWORK CONSTRUCTED FROM PENTANUCLEAR CLUSTERS FOR SELECTIVE SORPTION OF GAS MOLECULES - Disclosed herein are highly interpenetrated robust metal-organic frameworks having the repeat unit Zn | 02-21-2013 |
20130048875 | OPTICAL ANALYSIS DEVICE, OPTICAL ANALYSIS METHOD AND COMPUTER PROGRAM FOR OPTICAL ANALYSIS - The inventive optical analysis technique uses an optical system capable of detecting light from a micro region in a solution, such as an optical system of a confocal microscope or a multiphoton microscope, to detect the light from the light-emitting particle to be observed while moving the position of the micro region in the sample solution (while scanning the inside of the sample solution with the micro region); generates time series light intensity data, and after smoothing the time series light intensity data; and detects in the smoothed time series light intensity data the light-emitting particle crossing the inside of the micro region individually, thereby enabling the counting of the light-emitting particle(s) or the acquisition of the information on the concentration or number density of the light-emitting particle. | 02-28-2013 |
20130062536 | Illumination Systems and Methods for Photoluminescence Imaging of Photovoltaic Cells and Wafers - Methods are presented for analysing semiconductor materials ( | 03-14-2013 |
20130062537 | COMBINATION OF LUMINESCENT SUBSTANCES - The invention relates to a luminescent composition comprising a component which can be excited by infrared (IR) radiation and a component which can be excited by ultraviolet (UV) radiation. The composition has a characteristic emission spectrum and may optionally be used together with a reading system adapted to the emission spectrum in order to mark substances or mixtures of substances. | 03-14-2013 |
20130068967 | Method for Generating a Microscope Image and Microscope - The invention relates to a method and a microscope for generating a microscopic image, wherein
| 03-21-2013 |
20130075626 | OPTICAL SYSTEM - An optical system includes a sample carrier receiving region configured to receive a carrier carrying a sample for processing, a source that emits an excitation signal having a wavelength within a first predetermined wavelength range, and a first set of optical components that direct the excitation signal along an excitation path to the sample carrier receiving region, wherein radiation having a wavelength within a second predetermined wavelength range is emitted from the sample carrier receiving region in response to receiving the excitation signal. The system further includes a detector configured to detect the emitted radiation and generates a signal indicative of a power of the detected radiation and a second set of optical components that directs the emitted radiation along a collection path to the detector and a power meter that measures a power of the radiation emitted from the sample carrier receiving region and generates a signal indicative thereof. | 03-28-2013 |
20130075627 | APPLYING EDGE-ON PHOTOLUMINESCENCE TO MEASURE BULK IMPURITIES OF SEMICONDUCTOR MATERIALS - Provided are photoluminescence spectroscopy systems and methods for identifying and quantifying impurities in a semiconductor sample. In some embodiments, the systems and methods comprise a defocused collimated laser beam illuminating a first sample surface, and collection by a collection lens of photoluminescence from a sample edge at the intersection of the first surface with a substantially orthogonal second surface, wherein the first sample surface is oriented from about 0° to 90° with respect to a position parallel to the collection lens. | 03-28-2013 |
20130082191 | STRESS-SENSITIVE MATERIAL AND METHODS FOR USING SAME - A stress-sensing material containing a matrix material and a photo-luminescent particle is disclosed, together with adhesives and coatings containing the stress-sensing material. Also disclosed are methods for preparing the stress-sensing material and measuring the stress on an article using the stress-sensing material. | 04-04-2013 |
20130087719 | LIGHT SOURCE DEVICE FOR TIME-DELAYED DETECTION OF FLUORESCENCE, AND IMAGE PICK-UP SYSTEM AND METHOD - The present invention discloses a light source device, image pick-up system and pick-up method for time-delayed detection of fluorescence, essentially applying a pulsed-excitation light source installed inside a light source device in conjunction with a shutter to pick up a photoluminescence image of an object located at a predetermined detection site, the light source device comprising: a pulsed-excitation light source for emitting light towards the predetermined detection site; and a controller for instructing the pulsed-excitation light source to emit light, the controller being connected in feedback signals to the shutter, thereby closing the shutter when the pulsed-excitation light source emits light and opening the shutter as soon as the light pulse terminates in order to effectively shield reflection light and diffusive reflection light to purely capture the photoluminescence data. | 04-11-2013 |
20130099135 | LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs. | 04-25-2013 |
20130099136 | FLUORESCENT NANOSCOPY DEVICE AND METHOD - A method for analysis of an object dyed with fluorescent coloring agents. Separately fluorescing visible molecules or nanoparticles are periodically formed in different object parts, the laser produces the oscillation thereof which is sufficient for recording the non-overlapping images of the molecules or nanoparticles and for decoloring already recorded fluorescent molecules, wherein tens of thousands of pictures of recorded individual molecule or nanoparticle images, in the form of stains having a diameter on the order of a fluorescent light wavelength multiplied by a microscope amplification, are processed by a computer for searching the coordinates of the stain centers and building the object image according to millions of calculated stain center co-ordinates corresponding to the co-ordinates of the individual fluorescent molecules or nanoparticles. Two-dimensional and three-dimensional images are provided for proteins, nucleic acids and lipids with different coloring agents. | 04-25-2013 |
20130105708 | Narrow band fluorophore exciter | 05-02-2013 |
20130105709 | Optical Cavity Mode Excitations in Magnetic Fluorescent Microparticles | 05-02-2013 |
20130112895 | Method for Characterising an Agri-Food Product and Device for Implementing Such a Method - The invention relates to a method for characterising one or more samples of an agri-food product, in particular intended for determining the naturality, freshness and authenticity of such a product and/or the conformity of same with a target product. The method of the invention is characterised in that it comprises: acquiring a plurality of natural fluorescence spectra of the sample; applying a multivariate or multi-path analysis method to said spectra, wherein said method provides a limited number F of variables representing said or each sample, in order to enable the representation thereof by a point (PE) in a space having F dimensions; calculating a distance (D) between said point representing said or each sample and a target (C | 05-09-2013 |
20130119272 | IMAGE OBTAINING APPARATUS, IMAGE OBTAINING METHOD, AND IMAGE OBTAINING PROGRAM - An image obtaining apparatus includes: a light source configured to irradiate a biological sample having a fluorescent label with an excitation light, the excitation light exciting the fluorescent label; an optical system including an objective lens, the objective lens being configured to magnify an imaging target of the biological sample; an image sensor configured to form an image of the imaging target magnified by the objective lens; a movement controller configured to move a focus position of the optical system in an extended range, the extended range being obtained by adding predetermined margins to both ends of the imaging target in a thickness range; and a light-exposure controller configured to expose the image sensor to light while moving the focus position of the optical system in the extended range. | 05-16-2013 |
20130119273 | Method and Apparatus for Illumination and Detection in RESOLFT Microscopy - A method for illumination and detection in RESOLFT microscopy using a pulsed or continuous light source for excitation light and switching light is characterized in that the excitation light ( | 05-16-2013 |
20130119274 | LUMINESCENT BORATES, MATERIALS AND ARTICLES INCORPORATING SUCH BORATES, AND METHODS AND APPARATUS FOR THEIR PRODUCTION AND USE IN ARTICLE AUTHENTICATION - Embodiments include luminescent materials and associated production methods. The material includes a crystal borate having a first substitutable element, neodymium substituted for the first substitutable element at a first substitution percentage of at least about 20 percent, and ytterbium substituted for the first substitutable element at a second substitution percentage. The material also may include chromium substituted for a second substitutable element. The material also may include a medium within which particles of the borate are incorporated. The medium, with the luminescent material particles, may form a security feature of an article. Embodiments of methods for identifying whether such a luminescent material is incorporated with an article include exposing a portion of the article to excitation in a chromium absorption band, and determining whether a detected emission produced by the article as a result of the excitation indicates an ytterbium emission after termination of the exposing step. | 05-16-2013 |
20130119275 | High Throughput Hot Testing Method And System For High-Brightness Light-Emitting Diodes - A method of performing a hot test of a wafer-level, packaged high-brightness phosphor converted light-emitting diode (pc-HBLED) includes selectively heating portions of the phosphor layer using a laser to provide a predetermined temperature gradient in the phosphor layer. The selective heating can directly heat the silicone in a silicone-based phosphor layer, or directly heat the active ion(s) of the phosphor in a Lumiramic™-based phosphor or even the active ion(s) of a silicone-based phosphor layer. A current is applied to the InGaN film to establish a predetermined temperature at the InGaN film junction, the film junction being adjacent to the phosphor layer. Photometric measurements are performed on the HBLED after the selective heating and during the applied electroluminescent current. This method quickly establishes the temperatures and temperature gradients in the HBLED consistent with those of an operating, product-level HBLED, thereby ensuring accurate binning of the HBLED. | 05-16-2013 |
20130119276 | Method for Measuring the Lifetime of an Excited State in a Sample - The present invention relates to a method for measuring the lifetime of an excited state in a sample, in particular a fluorescence lifetime, and to an apparatus for carrying out such a method. First, an excitation pulse is generated and a sample region is illuminated with the excitation pulse. Then, a first digital data sequence is generated which is representative of the power-time profile of the excitation pulse, and a first switching instant is determined from the first digital data sequence. Moreover, the detection light emanating from the sample region is detected by a detector, and a second digital data sequence is generated which is representative of the power-time profile of the detection light, and a second switching instant is determined from the second digital data sequence. Finally, the time difference between the first and second switching instants is calculated. | 05-16-2013 |
20130119277 | DYNAMIC SIGNAL EXTENSION IN OPTICAL DETECTION SYSTEMS - Systems and methods for measuring a target in a sample, the target being capable of generating an emitted light in response to an excitation light. In an example system, an excitation light source generates the excitation light along an excitation optical path. An attenuation filter arrangement selectively adds an attenuation filter to the excitation optical path. The attenuation filter attenuates the excitation light by a corresponding attenuation factor. The excitation light exits the attenuation filter arrangement along the excitation optical path to illuminate the sample. A light energy detector receives the emitted light generated in response to the excitation light, and outputs a measured signal level corresponding to an emitted light level. If the light energy detector indicates an overflow, signal measurement is repeated with attenuation filters of increasing attenuation factors until the measured signal level does not overflow. | 05-16-2013 |
20130126754 | METHOD FOR MEASURING BIOLOGICAL CONTAMINATION OF SEA WATER DESALINATION FACILITY AND SYSTEM THEREOF - The present invention relates to a method for measuring degree of biological contamination in a sea water desalination facility, and is characterized by comprising the following steps of: a) collecting any one selected from a group consisting of raw sea water flowing into the sea water desalination facility, pre-treated water prepared by pre-treating the raw sea water, product water (permeate) produced after the pre-treated water goes through a desalination process and brine; and b) measuring wavelength and strength of a natural phosphor, which is contained in the raw sea water, pre-treated water, product water (permeate) or brine, using a fluorescence spectrophotometer. | 05-23-2013 |
20130126755 | Method and device for simultaneous multi-channel and multi-method acquisition of synchronized parameters in cross-system fluorescence lifetime applications - A device for simultaneous multi-channel, multi-method acquisition of synchronized parameters in fluorescence lifetime applications is provided with a fluorescence macroscope, microscope or nanoscope, a pulsed laser source, a beam splitter, a TSCSPC detector, and a synchronized peripheral device. A sample is irradiated with a pulsed, high frequency, polarized or unpolarized ps or ns laser beam. The fluorescence radiation from the sample is guided onto a beam splitter to generate two partial beams that are deflected onto a list-mode detector operating by space- and time-correlated single photon counting. All physical parameters of each photon are acquiring by the list-mode detector simultaneously and saved in control electronics. Simultaneously, further parameters are acquired in synchronization by a peripheral device and saved. The saved parameters of the list-mode detector and of the peripheral device are combined to a multi-parameter, multi-method acquisition system in a | 05-23-2013 |
20130126756 | FLUORESCENCE IMAGING APPARATUS AND METHOD - A fluorescence emission imaging method and apparatus allows for high frame rate imaging in scattering medium as well as for fluorescence, phosphorescence, or luminescence lifetime imaging, time-resolved fluorescence, phosphorescence, or luminescence lifetime spectroscopy and imaging. A method involves providing an illumination beam, propagating the illumination beam to a light modulator array, modulating the illumination beam so as to generate an array of point sources, wherein each of the point sources is modulated at a frequency, imaging the modulated illumination beam on the object, and detecting a fluorescent, phosphorescent, or luminescent emission from the object. An optical imaging component in the form of a modulation mask has multiple bands. Each band has alternating transmissive and/or reflective and/or absorptive regions that are patterned such that light scanned over a band will be modulated at a band-related frequency. | 05-23-2013 |
20130126757 | Methods, Systems and Apparatuses for Testing and Calibrating Fluorescent Scanners - Disclosed are calibration apparatuses for fluorescent microscopy instruments and methods of making and using them. Specifically, disclosed are calibration apparatuses with a fluorescent layer, such as photoresist, deposited on a substrate, with an optional layer of a reflective material, such as chrome. Illumination of the fluorescent and/or reflective layers, and detection and analysis of the resulting emissions allows evaluation of the instrument with respect to both reflective and fluorescent channels. Selection of appropriate fluorescent materials for the one or more fluorescent layers allows the evaluation of an instrument with respect to different fluorophores, as would be used with an instrument capable of two color detection. Inclusion of a reflective layer further allows the evaluation and calibration of all optical channels of an instrument, including the reflective channel and two or more fluorescent channels, with a single calibration apparatus for imaging criteria such as uniformity, contrast and emission signal strength. | 05-23-2013 |
20130126758 | METHODS AND SYSTEMS FOR IMAGE DATA PROCESSING - Embodiments of the computer-implemented methods, storage mediums, and systems may be configured to determine locations of particles within a first image of the particles. The particles may have fluorescence-material associated therewith. The embodiments may include calculating a transform parameter, and the transform parameter may define an estimated movement in the locations of the particles between the first image of the particles and a second image of the particles. The embodiments may further including applying the transform parameter to the locations of the particles within the first image to determine movement locations of the particles within the second image. | 05-23-2013 |
20130126759 | OPTICAL MICROSCOPY WITH PHOTOTRANSFORMABLE OPTICAL LABELS - An apparatus includes a position-sensitive detector to detect intensities of radiation as a function of position on the detector, and an optical system, characterized by a diffraction-limited resolution volume, adapted for imaging light emitted from activated and excited phototransformable optical labels (“PTOLs”) in a sample onto the position sensitive-detector. A first light source provides activation radiation to the sample to activate a subset of the PTOLs that are distributed in the sample with a density greater than an inverse of the diffraction-limited resolution volume of the optical system. A second light source provides excitation radiation to the sample to excite a portion of the PTOLs in the subset of the PTOLs. A controller controls one both of the activation radiation and the excitation radiation provided to the sample such that a density of PTOLs in the portion of the PTOLs is less than the inverse of the diffraction-limited resolution volume. | 05-23-2013 |
20130146787 | METHOD FOR DETERMINING MATERIAL PARAMETERS OF A DOPED SEMICONDUCTOR SUBSTRATE BY MEASURING PHOTOLUMINESCENT RADIATION - Method for determining material parameters of a doped semiconductor substrate, including: applying electromagnetic excitation radiation in order to produce luminescent radiation in the semiconductor substrate, the temporal profile of the excitation radiation intensity is periodically modulated, so that the rate of generation of charge carrier pairs in the substrate has a maximum and minimum during an excitation period, and at least the relative temporal profile of the rate of generation G(t) is determined by time-dependent measurement of the excitation radiation intensity, time-resolved measuring luminescent radiation intensity emanating from a measuring region, at least the relative temporal profile of the intensity of the luminescent radiation Φ(t) is measured during an excitation period, determining a material parameter of the semiconductor substrate based on G(t) and Φ(t). The effective lifetime of the substrate is determined from the time difference between the maximum of G(t) and a corresponding maximum of Φ(t). | 06-13-2013 |
20130153788 | NON-CONTACT TOTAL EMISSION DETECTION METHOD AND SYSTEM FOR MULTI-PHOTON MICROSCOPY - A multi-photon microscope having an illumination source that transmits an illumination light into a housing having an objective lens arrangement for illuminating a sample disposed outside the housing and directing a first portion of emission light emitted from the sample to a detection system is disclosed. A light collection system is disposed proximate the objective lens arrangement for directing a second portion of emission light in a coaxial relationship with the first portion of emission light to the detection system such that substantially all of the emission light on, around and above the illumination region is detected. | 06-20-2013 |
20130153789 | LUMINESCENT MATERIALS, ARTICLES INCORPORATING LUMINESCENT MATERIALS, AND METHODS FOR PERFORMING ARTICLE AUTHENTICATION - Embodiments of luminescent materials and articles include first and second particles of first and second inorganic host lattices. The first particles are capable of producing first emissions having one or more first emission peaks at one or more first wavelengths. The first emissions have a first decay half-life that is long enough for the first emissions to be perceptible to the human eye for a first time period that begins when appropriate excitation of the luminescent material is discontinued. The second particles are capable of producing second emissions having one or more second emission peaks at one or more second wavelengths. The second emissions have a second decay half-life that is longer than the first decay half-life by a decay time difference that is sufficient for the second emissions to be perceptible to the human eye for a second time period that begins after the first time period. | 06-20-2013 |
20130161536 | MICROORGANISM DETECTING APPARATUS CALIBRATION METHOD AND MICROORGANISM DETECTING APPARATUS CALIBRATION KIT - A method for calibrating a microorganism detecting apparatus including drawing, into a microorganism detecting apparatus, polystyrene particles that, when exposed to light produce fluorescence of essentially the same intensity as the intensity of fluorescence produced by microorganisms; exposing the polystyrene particles to light from a light source of the microorganism detecting apparatus and detecting, using a fluorescence detector of the microorganism detecting apparatus, the fluorescence produced from the polystyrene particles; and calibrating the microorganism detecting apparatus based on the intensity of the detected fluorescence. | 06-27-2013 |
20130168572 | STIMULATED EMISSION AND ENHANCED DETECTION OF CHEMICALS AND CHEMICAL COMPOUNDS - A method and apparatus for remotely detecting, locating, and identifying chemicals and chemical compounds through optically opaque materials. Electromagnetic radiation in the Terahertz range emitted from an antenna array is modulated to excite target molecules. The apparatus then stops the excitation energy and the molecules emit an electromagnetic signature detectable by the device at standoff distances. | 07-04-2013 |
20130168573 | MEASURING DEVICE, MEASURING SYSTEM, MEASURING METHOD, CONTROL PROGRAM, AND RECORDING MEDIUM - A measuring device ( | 07-04-2013 |
20130168574 | Silicophosphate phosphors - The invention relates to compounds of the general formula I | 07-04-2013 |
20130175456 | PHOTOLYTICALLY AND ENVIRONMENTALLY STABLE MULTILAYER STRUCTURE FOR HIGH EFFICIENCY ELECTROMAGNETIC ENERGY CONVERSION AND SUSTAINED SECONDARY EMISSION - Disclosed is a method for converting a primary electromagnetic radiation to a longer output wavelength that includes providing an energy conversion layer having a first photoluminescent material and a second photoluminescent material, exposing the energy conversion layer to the primary electromagnetic radiation, and transferring at least a portion of absorbed energy from the first photoluminescent material to the second photoluminescent material by dipolar coupling, such that the second photoluminescent material subsequently emits the longer output wavelength. | 07-11-2013 |
20130175457 | SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS DEVICE AND SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS METHOD - In the present invention, a specimen is made to flow on a metal film on a prism, and excitation light (α) is emitted in a predetermined direction. By changing the position of a reflective member that reflects the excitation light (α), and adjusting the orientation of a reflective surface of the reflective member, the incident angle (θ) is changed while maintaining a state in which the excitation light (α) that enters the prism is reflected at a specific position on the metal film. The intensity of light to be generated on the metal film is measured, and the reflective member is positioned to match the position of the reflective member and the orientation of the reflective surface when a maximum amount of light is measured. | 07-11-2013 |
20130181143 | MICROSCOPY WITH ADAPTIVE OPTICS - A method of manipulating a focused light beam includes focusing a beam of excitation light with a lens to a focal spot within a sample, where a cross-section of the beam includes individual beamlets. Directions and/or relative phases of the individual beamlets of the excitation beam at a rear pupil of the lens are individually varied with a wavefront modulating element, and emission light emitted from the focal spot is detected while the directions or relative phases of individual beamlets are varied. The directions of individual beamlets are controlled to either maximize or minimize the emission light from the focal spot, and the relative phases of individual beamlets are controlled to increase the emission light from the focal spot. | 07-18-2013 |
20130181144 | ARTICLES INCORPORATING THERMOGRAPHIC PHOSPHORS, AND METHODS AND APPARATUS FOR AUTHENTICATING SUCH ARTICLES - Embodiments include methods and apparatus for identifying a thermographic phosphor (e.g., Er:YIG) incorporated on or within an article. The method and apparatus embodiments include an excitation energy generator selectively exposing the article to excitation energy in an absorption band of the thermographic phosphor. An emitted radiation detector detects first emission characteristics of first emitted radiation from the article within an emission band of the thermographic phosphor when the article has a first temperature, and detects second emission characteristics of second emitted radiation from the article within the emission band when the article has a second temperature that is different from the first temperature. A temperature adjustment element is configured to adjust the temperature of the article. Embodiments further include a processing system determining whether the first emission characteristics are sufficiently different from the second emission characteristics. | 07-18-2013 |
20130187061 | METHOD FOR NONDESTRUCTIVE TESTING OF WORKPIECE SURFACES - A method for nondestructive testing of workpiece surfaces by a fluorescent penetration test is disclosed. An embodiment of the method includes a) cleaning the area of the workpiece surface that is to be inspected; b) applying a fluorescent liquid penetrant to the area of the workpiece surface that is to be inspected, where the penetrant penetrates into possible recesses in the workpiece surface; c) removing the excess penetrant from the workpiece surface; d) applying a developer to the area of the workpiece surface that is to be inspected; e) bleaching the fluorescent penetrant by a beam of light in the layer formed by applying the developer to the workpiece surface; and 0 visual evaluation of the fluorescent penetrant remaining in the recesses present in the workpiece surface. | 07-25-2013 |
20130193346 | Method for Identifying an Object - The invention relates to a method for identifying an object, wherein said object has a security element, which contains one or more inorganic luminescent pigments, wherein the method comprises the steps of producing an emission spectrum of the luminescent pigment and comparing the obtained emission spectrum with the spectrum specified for the security element. The invention further relates to a security element, by means of which it is possible to determine the authenticity of a product in a simple manner. | 08-01-2013 |
20130193347 | METHOD AND DEVICE FOR DETERMINING CONTENT OF THE MIDDLE AND PROTEIN BOUND UREMIC TOXINS IN A BIOLOGICAL FLUID - This invention relates to a novel method and a device for determining middle and protein bound uremic toxins in the biological fluids. More specifically, the present invention relates to an optical method utilizing fluorescence, preferable fluorescence of the spent dialysate, and a specific model, including a unique set of optical spectral components at certain wavelengths, to determine, preferable on-line, the concentration of the middle and protein bound uremic toxins such as beta2-microglobulin (B2M), and indoxyl sulfate (IS). | 08-01-2013 |
20130200276 | SUBSTANCE DETECTION, INSPECTION AND CLASSIFICATION SYSTEM USING ENHANCED PHOTOEMISSION SPECTROSCOPY - A handheld or portable detection system with a high degree of specificity and accuracy, capable of use at small and substantial standoff distances (e.g., greater than 12 inches) is utilized to identify specific substances and mixtures thereof in order to provide information to officials for identification purposes and assists in determinations related to the legality, hazardous nature and/or disposition decision of such substance(s). The system uses a synchronous detector and visible light filter to enhance detection capabilities. | 08-08-2013 |
20130200277 | SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL - A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones. | 08-08-2013 |
20130214176 | Spatially Correlated Light Collection from Multiple Sample Streams Excited with a Line Focused Light Source - An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector. | 08-22-2013 |
20130214177 | METHOD OF CALIBRATING AND CORRECTING COLOR-BLEED FACTORS FOR COLOR SEPARATION IN DNA ANALYSIS - A method includes calibrating color bleed factors of optical detector channels of a sample processing apparatus through processing a color bleed calibration substance which includes a plurality of different size fragments replicated from different groups of DNA loci, wherein fragments in a same group are labeled with a same fluorescent dye, and fragments in different groups are labeled with different fluorescent dyes having different emission spectra, wherein the different size fragments are processed during different acquisition times. | 08-22-2013 |
20130214178 | SURFACE COATING FOR INSPECTION - A method of inspecting an article includes: applying an organic liquid substance over at least a portion of the article to be inspected so as to form a surface layer thereon, wherein said surface layer is luminescent; irradiating the article with the surface layer thereon; and scanning the article to determine its shape. | 08-22-2013 |
20130221237 | LAMINATED GLASS SHEET DEPTH PROFILE DETERMINATION - Depth-sensitive fluorescent spectroscopy can be executed by directing UV radiation through a face of a laminated glass sheet to induce distinct fluorescence in respective target layers of the laminated glass sheet. The respective target layers define glass compositions and relative indices of refraction that permit formation of an externally-viewable fluorescent intensity profile across the target layers of the laminated glass sheet. In an alternative embodiment, non-UV laser radiation is directed from a non-UV laser radiation source through a face of the laminated glass sheet to define a series of multi-photon focal points in the laminated glass sheet and induce fluorescence in respective ones of the plurality of target layers of the laminated glass sheet at a UV excitation frequency that exceeds the frequency of the radiation source. | 08-29-2013 |
20130221238 | Systems For And Methods Of Characterizing The Thickness Profile Of Laminated Glass Structures - Systems for and methods of characterizing the thickness profile of laminated glass structures are disclosed, wherein the laminated glass structure has at least one gradual transition region between adjacent glass layers. The method includes sequentially focusing laser light at different focuses along a line within the laminated glass structure. The sequentially formed focuses define corresponding micro-volumes from which fluorescent light emanates due to a multiphoton process. The variation in the intensity of the detected fluorescent light from each micro-volume as a function of distance into the laminated glass structure is used to determine the relative locations of the multiple layers and the at least one gradual transition region. | 08-29-2013 |
20130221239 | METHOD OF SHIELDING ULTRAVIOLET LIGHT AND INCREASING VISIBLE LIGHT, AND ULTRAVIOLET-LIGHT-SHIELDING AND VISIBLE-LIGHT-INCREASING MATERIAL WHICH ENABLES IMPLEMENTATION OF THE METHOD - Provided is a method of shielding ultraviolet light and increasing visible light, enabling shielding or removal of ultraviolet light, transmission of visible light, effective utilization of ultraviolet energy to obtain visible light, and not requiring use of rare metal thus being low in cost. The method has: a first excitation step of exciting a fluorescent material by external light of 200 nm to 330 nm: an internal light emission step in which the fluorescent material excited in the first excitation step emits internal light of 330 nm to 400 nm; a second excitation step of exciting the same or a different fluorescent material by external light of 330 nm to 400 nm and by the internal light of 330 nm to 400 nm; and a visible light emission step in which the fluorescent material excited in the second excitation step emits visible light of 400 nm or more. | 08-29-2013 |
20130221240 | FLUORESCENCE IMAGE PRODUCING METHOD, FLUORESCENCE IMAGE PRODUCING APPARATUS, AND FLUORESCENCE IMAGE PRODUCING PROGRAM - Method and apparatus for producing an image associated with a biological sample is provided. The biological sample is focused on the biological sample based on fluorescence of a first fluorescent material and the image is captured based on fluorescence of the second fluorescent material. A computer readable memory device storing instructions to cause a data processing unit is also provided. | 08-29-2013 |
20130228704 | WAVELENGTH-RESOLVING AND HIGH SPATIAL RESOLUTION FLUORESCENCE MICROSCOPY - A method for wavelength-resolving and high spatial resolution fluorescence microscopy in which fluorescence labels in a sample are repeatedly excited to emit fluorescence radiation and frames including images of isolated labels are produced with a microscope. The positions of the images of the isolated fluorescing labels are localized with a localization precision exceeding the optical resolution of the imaging beam path of the microscope. The imaging beam path of the microscope has a diffractive element which, during the imaging, diffracts the image of the sample comprising the isolated fluorescing labels into a first diffraction order so that each frame contains the first diffraction order images of the isolated fluorescing labels. A parameter of the first diffraction order images of the isolated fluorescing labels is evaluated and an indication of the wavelength of the isolated fluorescing labels is derived from this evaluated parameter. | 09-05-2013 |
20130228705 | OPTICAL ANALYSIS METHOD USING THE LIGHT INTENSITY OF A SINGLE LIGHT-EMITTING PARTICLE - There is provided a scanning molecule counting method using an optical measurement with a confocal microscope or a multiphoton microscope, enabling characterization of a light-emitting particle or identification of a light-emitting particle with emitted light intensity of a single light-emitting particle measured individually. In the inventive optical analysis technique, with reference to the ratio of the intensities of simultaneously generated signals of the lights of at least two light-emitting sites having mutually different emission wavelengths, possessed by a light-emitting particle contained in a sample solution, the intensities being measured with moving the position of the light detection region of an optical system by changing the optical path of the optical system, a single light-emitting particle corresponding to the signals is identified, and the kind, the size, etc. of the light-emitting particle is identified. | 09-05-2013 |
20130228706 | OPTICAL ANALYSIS DEVICE, OPTICAL ANALYSIS METHOD AND COMPUTER PROGRAM FOR OPTICAL ANALYSIS FOR OBSERVING POLARIZATION CHARACTERISTICS OF A SINGLE LIGHT-EMITTING PARTICLE - There is provided an optical analysis technique which observes a polarization characteristic of a light-emitting particle using the scanning molecule counting method using an optical measurement with a confocal microscope or a multiphoton microscope. In the inventive optical analysis technique, the light detection region is irradiated with excitation light consisting of predetermined polarized light component(s) and the intensity of at least one polarized light component of the light from the light detection region is detected with moving the position of the light detection region of the optical system in a sample solution; a signal of each light-emitting particle is detected individually in the intensity of at least one polarized light component; and based on the intensity of at least one polarized light component of the signal of the detected light-emitting particle, the polarization characteristic value of the light-emitting particle is computed. | 09-05-2013 |
20130234043 | METHOD AND SYSTEM FOR ITEM AUTHENTICATION AND CUSTOMIZATION - A method of illuminating an item is disclosed. The method includes applying adhesive to the item, interspersing a taggant in the adhesive, illuminating the item with an excitation signal, sensing luminescence emitted by the taggant in response to illumination by the excitation signal, and determining the authenticity of the item based on the sensed emitted luminescence. The item can include any item benefited by authentication, and can include a postage stamp. A method of customizing an item is disclosed. This can include the steps of preparing a substrate, applying a security feature to the substrate, printing non-customized information on the substrate, receiving image information, and printing the image information on the substrate. | 09-12-2013 |
20130234044 | MEASUREMENT METHOD FOR DETERMINING AN ORGAN FUNCTION - The invention relates to a method for acquiring data in order to determine organ function, in particular the liver or kidney function, comprising one or more polymethine fluorescent dyes having a fluorescence emission maximum, measured in ethanol, of less than or equal to 820 nm, and to the use of dyes as markers for acquiring data in order to determine the organ function. The invention further relates to a kit for determining an organ function with a marker dye, and to a device for acquiring data in the method. | 09-12-2013 |
20130234045 | CORRECTION METHOD OF FLUORESCENCE SENSOR AND FLUORESCENCE SENSOR - A correction method of a fluorescence sensor includes a first detection signal acquiring step for acquiring, at a first temperature, a first detection signal using a fluorescence sensor having a temperature detecting function and a temperature adjusting function, a second detection signal acquiring step for acquiring, at a second temperature, a second detection signal when an analyte amount is the same as an analyte amount in the first detection signal acquiring step, a correction coefficient calculating step for calculating, on the basis of the first detection signal and the second detection signal, a correction coefficient for correcting the fluorescent light detection signal, and a correcting step for correcting subsequent detection signals using the correction coefficient and a temperature detection signal. | 09-12-2013 |
20130234046 | METHODS AND SYSTEMS FOR ANALYZING AIRBORNE COMPOUNDS - In systems and methods for analyzing traces of airborne compounds, the air to be analyzed is circulated for a given length of time through a small-diameter analysis tube while lowering the temperature of the air at the entrance to the analysis tube. Condensation and deposits of compounds are formed on the inner walls of the analysis tube. A scraping liquid is circulated through the analysis tube to scrape off the deposits. The compounds in the deposits are concentrated at the front of this liquid. The front of the liquid is then analyzed to identify the compounds. | 09-12-2013 |
20130234047 | SYSTEM AND METHOD FOR CONTROLLED INTENSITY ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for controlled illumination in a bioanalysis or other system where excitation of fluorescent molecules is desirable. In an embodiment, an illumination system is described which can provide excitation light at a controlled intensity to provide quantitative results. In an embodiment, a solid state light engine is described which includes a plurality of color channels each providing light output suitable for exciting a fluorescent molecule, a light to frequency converter which receives a portion of the light output, a counter which maintains a count of a signal from the light to frequency converter, and a light intensity circuit, responsive to the counter, which adjusts the color channels to control the intensity of the light output. | 09-12-2013 |
20130234048 | Device and Method for Reading Out X-Ray Information Stored in a Fluorescent Storage Layer - The present invention relates to an apparatus and to a corresponding method for reading out X-ray information stored in a storage phosphor layer ( | 09-12-2013 |
20130256561 | PULSE AMPLITUDE MODULATED CHLOROPHYLL FLUOROMETER - Chlorophyll fluorometry may be used for detecting toxins in a sample because of changes in micro algae. A portable lab on a chip (“LOAC”) based chlorophyll fluorometer may be used for toxin detection and environmental monitoring. In particular, the system may include a microfluidic pulse amplitude modulated (“PAM”) chlorophyll fluorometer. The LOAC PAM chlorophyll fluorometer may analyze microalgae and cyanobacteria that grow naturally in source drinking water. | 10-03-2013 |
20130256562 | CONCENTRATION MEASUREMENT USING LUMINESCENCE - A method of measuring the concentration of a substance, using a sensor ( | 10-03-2013 |
20130256563 | HIGH-RESOLUTION FLUORESCENCE MICROSCOPY - A microscopy method for producing a high-resolution image of a 2-dimensional sample. The method includes exciting statistically blinking fluorophores in a sample by irradiating the sample with illumination radiation, repeatedly imaging the sample onto a spatially resolving detector in an image field that covers only a part of the sample to thereby obtain a frame sequence, generating an image from the frame sequence, the image having a spatial resolution increased beyond the optical resolution limit using a cumulant function, moving the position of the image field on the sample at least once and repeating the imaging and generating steps to obtain one image for each position of the image field, and combining the resultantly obtained images to form a complete image of the sample. | 10-03-2013 |
20130256564 | STED Microscopy With Pulsed Excitation, Continuous Stimulation, And Gated Registration Of Spontaneously Emitted Fluorescence Light - In a STED fluorescence light microscope pulses of excitation light ( | 10-03-2013 |
20130270456 | METHOD AND DEVICE FOR HUNTERS SAFETY ALONG TRAILS LEADING TO A HUNTING AREA IN THE DARK - The present invention relates to a method for hunter's safety to allow them to find | 10-17-2013 |
20130270457 | Matrix-Incorporated Fluorescent Silica for Anti-Counterfeiting - The present invention relates to a fluorescent dye-incorporated silica material. A fluorescent dye is covalently bonded to a silica matrix. The invention also provides for a method for verifying the authenticity of a product, wherein the fluorescent silica material is present in or on a product, and the material is tested for fluorescence or structure. | 10-17-2013 |
20130277575 | CHARACTERIZATION OF NEAR FIELD TRANSDUCERS - An approach for characterizing an optical near field transducer (NFT) involves providing excitation radiation to the NFT. The NFT emits photoluminescent radiation in response to the excitation radiation. The output radiation from the NFT is filtered so that a portion of the photoluminescent radiation emitted by the NFT passes through the filter and the excitation radiation is substantially blocked. A detector detects the portion of photoluminescent radiation and outputs an electrical signal in response to detection of the portion of photoluminescent radiation. | 10-24-2013 |
20130277576 | Fluorescence Emissions Detector - A light source is gated ON and OFF in response to a pulsed signal. Photo emissions from the light source are coupled to a material under test. Resonant fluorescent emissions from the material are coupled to a photodiode. Current from the photodiode is coupled into an amplifier system comprising a first and second amplifier stages. The first amplifier stage is gated to a low gain when the light source is turned ON and the gain is increased when the light source goes from ON to OFF. The second amplifier stage has digitally programmable offset and gain settings in response to control signals. The output of the second amplifier stage is digitized by an analog to digital converter. A controller generates the pulse control signal and the control signals. | 10-24-2013 |
20130284944 | INSULATOR AND USE THEREOF - An object of the present invention is to provide an insulator which can suppress quenching between fluorescent dyes and enhance fluorescence intensity. The present invention provides, in order to achieve this object, an insulator which contains a ring entity of nonplanar structure and suppresses reduction in fluorescence intensity of one or two or more fluorescent labels adjacent to the insulator. | 10-31-2013 |
20130284945 | METHOD AND APPARATUS THAT UTILISES FLUORESCENCE TO DETERMINE PLANT OR BOTANICAL ORIGIN CHARACTERISTICS OF HONEY - Methods and apparatus are described for the measurement of honey plant origin characteristics via fluorescence. | 10-31-2013 |
20130292582 | Methods and Systems for Controlling the Flow of Particles for Detection - A method of focusing particles is provided. The method includes transiting a fluid containing particles therein through a channel at a flow rate and adjusting the flow rate for a desired transit time through an interrogation zone through which a light from an excitation source passes. The method further includes optically exciting the particles with the excitation source, detecting an optical signal from the particles, and analyzing the optical signal. The particles may be droplets. Further, the particles may transit the interrogation zone in single file. A system of focusing particles is also provided. The system includes a channel having an inlet for accepting a fluid containing particles. The system further includes a flow adjuster configured to adjust the flow rate for a desired transit time through an interrogation zone, a light source configured to optically excite the particles, and a detector configured to detect optical signals from the particles. | 11-07-2013 |
20130299718 | Stack Gas Measurement Device and Method Thereof - A gas sampling device includes an analysis block defining a first portion of a chamber and a dilution block defining a second portion of the chamber. The sampling device includes an exhaust gas orifice at the first portion for withdrawing gas from the chamber in response to an applied suction, a sample gas orifice at the second portion to modify passage of a sample gas entering the chamber in response to the suction, and a dilution gas orifice at the second portion to modify passage of a dilution gas entering the chamber in response to the suction. | 11-14-2013 |
20130299719 | MOLECULAR NEAR-INFRARED TO VISIBLE LIGHT UPCONVERSION LUMINESCENCE - The present invention relates to a self-assembled helical metallic complex of formula (1): [M | 11-14-2013 |
20130313444 | METHOD AND APPARATUS FOR TESTING LUMINESCENT FILMS - A structure for testing a luminescent film includes a Lambertian light source, an integrating sphere having an input port, and a measuring device. The Lambertian light source includes a mixing chamber having an input port and an output port, and a light emitter coupled to the input port. During testing the luminescent film is positioned between the output port of the mixing chamber and the input port of the integrating sphere. The measuring device is optically coupled to the integrating sphere. | 11-28-2013 |
20130320237 | OIL DETECTION PROCESS - A process for detecting oil or lubricant contamination in a manufactured product, the process comprising adding a fluorescent taggant to oils or lubricants contained in processing machinery for the product, irradiating the product with radiation, such as infrared or ultraviolet radiation, and detecting radiation emitted from the irradiated product. | 12-05-2013 |
20130327957 | FLUORESCENCE FLOW CYTOMETRY - A flow cytometer including a laser, indexing structure, adjustment structure, and sensor structure. The cytometer is conventionally used with a removable microfluidic cassette, which is installed at a first position that is enforced by the indexing structure. The adjustment structure changes a relative position between an interrogation aperture of the cassette and the laser beam. Feedback from the sensor structure is used to optimize propagation of the laser through the interrogation aperture to reduce (and hopefully eliminate) autofluorescence caused by beam impingement onto the cassette. | 12-12-2013 |
20130327958 | SCANNER PHOTOMETER & METHODS - A scanning photometer and attendant methods are provided. The scanning photometer is generally characterized by first and second fluorophore excitation sources, an objective lens, and a common emission detector for the detection of first and second fluorophore emission originating from the excitation of the fluorophores via passage of excitation energy, via an optical path of the objective lens, from the excitation sources. Excitation energy and emission energy conditioning elements are likewise provided, operatively interposed before or after the objective lens as the case may be. | 12-12-2013 |
20130341528 | Matrix-Incorporated Fluorescent Silica with On/Off Functionality for Anti-Counterfeiting - A fluorescent material includes a silica matrix, and a fluorescent dye compound covalently bonded to the silica matrix. The fluorescent dye compound may have first and second absorption wavelengths and an emission wavelength. A method for producing a photoswitchable fluorescent material includes combining silane monomers and fluorescent silane dyes, and initiating a polymerization reaction between the silane monomers and the photoswitchable fluorescent silane dyes, thereby creating photoswitchable fluorescent dye compounds covalently bonded to a silica matrix. The authenticity of a product may be verified according to a method in which a fluorescent material is present in or on a product, and the material is tested for fluorescence at first and second absorption wavelengths, the presence of structural characteristics, or both. The fluorescent material may exhibit on/off functionality through the use of the fluorescent material at different absorption wavelengths. | 12-26-2013 |
20140001375 | SAMPLE ANALYSIS SYSTEM WITH SPOTLIGHT ILLUMINATION | 01-02-2014 |
20140014856 | Biosensor - Optical sensors comprising a fluidic channel through which fluid carrying magnetised beads may be passed, an optical source for illuminating fluid as is passes through the channel, a sensor for detecting fluorescence emitted by the beads when illuminated by the optical source, and magnet means arranged to temporarily capture and retain the magnetic beads at an assay point in the fluidic channel illuminated by the optical source and monitored by the sensor. Methods and further apparatus relating to the same. | 01-16-2014 |
20140021368 | Quantum Dot Luminescent Materials - A quantum dot dispersed glass article is disclosed herein and associated articles, products, and methods of making thereof. In an aspect, a glass material can incorporate one or more quantum dot dispersed therein, wherein the one or more quantum dot luminesces upon excitation from an excitation source. In another aspect, the quantum dot can take a variety of shapes and sizes. In another aspect, the quantum dot can be water soluble. In yet another aspect, the quantum dot can be dispersed within one or more glass cavities. | 01-23-2014 |
20140021369 | ARTICLES, METHODS OF VALIDATING THE SAME, AND VALIDATION SYSTEMS EMPLOYING DECAY CONSTANT MODULATION - Articles, methods of validating the articles, and validating systems are provided herein. In an embodiment, an article includes a substrate and a security feature on the substrate. The security feature includes a first region that has a first ink composition and a second region that has a second ink composition. The first ink composition includes a first luminescent phosphor and the second ink composition includes a second luminescent phosphor that is different from the first luminescent phosphor. The first luminescent phosphor and the second luminescent phosphor have indistinguishable excitation energy wavelengths, indistinguishable emission wavelengths, and distinguishable temporal decay properties. | 01-23-2014 |
20140021370 | MICROPARTICLE MEASUREMENT APPARATUS AND MICROPARTICLE ANALYSIS METHOD - There is provided a microparticle measurement apparatus including a first light source configured to irradiate excitation light on a droplet containing a microparticle, the droplet being discharged from an orifice, a second light source configured to irradiate illumination light on the droplet for acquiring an image of the droplet, a light receiving element configured to detect fluorescence generated from the microparticle due to the irradiation of the excitation light, and to acquire an image of the droplet, and a filter member configured to be arranged between the droplet and the light receiving element. The filter member includes a first area through which the fluorescence and the illumination light pass, and a second area that is provided around the first area and that has a wavelength selectivity which lets the fluorescence pass through but blocks the illumination light. | 01-23-2014 |
20140021371 | TWO-PHOTON 3-D FIONA OF INDIVIDUAL QUANTUM DOTS - Microscopy is performed by imaging individual quantum dots (QD) using two-photon (2P) microscopy of in an aqueous environment with widefield and point-scan excitations at nanometer accuracy. | 01-23-2014 |
20140034847 | PHOTOLUMINESCENT OXYGEN PROBE TACK - A photoluminescent oxygen probe comprising a tack with a layer of a pressure-sensitive adhesive and an oxygen-sensitive photoluminescent element on the underside of the head. The probe is effective for sensing oxygen concentration within an enclosed space by puncturing the container defining the enclosed space the with the probe's shank and adhering the underside of the probe's head to the container so as to sealingly surround the puncture, thereby placing the oxygen-sensitive photoluminescent dye on the underside of the probe's head into sensible communication with the enclosed space through the puncture hole. | 02-06-2014 |
20140042339 | MICROSCOPE WITH A VIEWING DIRECTION PERPENDICULAR TO THE ILLUMINATION DIRECTION - A microscope and imaging method in which a layer of the sample is illuminated by a thin strip of light and the sample is viewed perpendicular to the plane of the strip of light. The depth of the strip of light thus essentially determines the depth of focus of the system. To record the image, the object is displaced through the strip of light, which remains fixed in relation to the detector, and fluorescent and/or diffused light is captured by a planar detector. Objects that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images. | 02-13-2014 |
20140042340 | Method and Apparatus for Tracking a Particle, Particularly a Single Molecule, in a Sample - For the purpose of tracking a movement of a particle in a sample, the particle is driven by light to emit photons, and the photons emitted by the particle are detected. The light applied to the sample features a light intensity distribution with a spatially limited minimum. The particle is tracked with the minimum of the light intensity distribution by moving the light intensity distribution with respect to the sample such that a rate of photons emitted by the particle remains minimal, and by taking an actual position of the minimum of the light intensity distribution in the sample as an actual position of the particle in the sample. | 02-13-2014 |
20140048722 | CAPILLARY ELECTROPHORESIS FLUORESCENT DETECTION SYSTEM - The invention includes a high sensitivity and high throughput capillary electrophoresis multiwavelength florescence detection system. The fluorescent detection system is configured to illuminate a relatively large volume of a single capillary or a plurality of capillaries, with a pixelated detection system capable of imaging an area of each capillary that differentiates the capillary walls, the space between the capillaries, and the internal liquid volume within the capillary. Only the desired pixels or image area are used for processing and generating an output signal. | 02-20-2014 |
20140048723 | AUTHENTICATION WITH ACCESS CONTROL AND CALIBRATION - A method of enabling an authenticating device ( | 02-20-2014 |
20140061504 | LOW RARE EARTH MINERAL PHOTOLUMINESCENT COMPOSITIONS AND STRUCTURES FOR GENERATING LONG-PERSISTENT LUMINESCENCE - A low rare earth mineral photoluminescent structure for generating long-persistent luminescence that utilizes at least a phosphorescent layer comprising one or more phosphorescent materials having substantially low rare earth mineral content of less than about 2.0 weight percent, and one or more fluorescent layers is disclosed. Further disclosed are methods for fabricating and using the inventive low rare earth mineral photoluminescent structure. A low rare earth mineral photoluminescent composition for generating long-persistent luminescence that utilizes at least one or more phosphorescent materials having substantially low rare earth mineral content of less than about 2.0 weight percent and one or more fluorescent materials is also disclosed, as well as, the methods for fabricating and using the inventive low rare earth mineral photoluminescent composition. | 03-06-2014 |
20140061505 | SQUARYLIUM DYES - Squarylium dyes with improved design flexibility via functionalization thereof thereby yielding desirable photophysical, solubility, thermal stability, and/or light stability properties, for example. The resulting dyes are useful in optical filters and as fluorescent indicators, for example. | 03-06-2014 |
20140061506 | SURFACE PLASMON-FIELD ENHANCED FLUORESCENCE MEASUREMENT DEVICE AND FLUORESCENCE DETECTION METHOD USING THE SAME - A surface plasmon-field enhanced fluorescence measurement device may be provided to accurately detect a specific substance even in the case in which a well member is used and achieving a simpler structure and a lower manufacturing cost, and a fluorescence detection method using the surface plasmon-field enhanced fluorescence measurement device. | 03-06-2014 |
20140077100 | MICROORGANISM DETECTING APPARATUS CALIBRATION METHOD AND MICROORGANISM DETECTING APPARATUS CALIBRATION KIT - A method for calibrating a microorganism detecting apparatus includes drawing into the microorganism detecting apparatus polystyrene particles with a weight-average molecular weight of no less than 250,000 and no more than 850,000 that, when exposed to light, produce a fluorescence of an intensity that is substantially identical to an intensity of fluorescence produced by a microorganism. The polystyrene particles are exposed to light from a light source of the microorganism detecting apparatus. A fluorescence detector of the microorganism detecting apparatus detects the fluorescence produced by a polystyrene particle. The microorganism detecting apparatus is calibrated based on a detected intensity of the fluorescence. | 03-20-2014 |
20140084181 | IRREGULAR EXCITATION OF OPTICAL SENSORS - A material is excited with light whose intensity is modulated according to a modulation signal. The modulation signal includes multiple transitions between at least two intensity levels, with times of at least a first contiguous sequence of the transitions being selected according to an irregular pattern. A response of the material to the excitation is detected. | 03-27-2014 |
20140091233 | Axial Illumination for Capillary Electrophoresis - System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. | 04-03-2014 |
20140097357 | QUANTUM-YIELD MEASUREMENT DEVICE - A quantum-yield measurement device | 04-10-2014 |
20140097358 | Method and Apparatus for Imaging a Structure Marked with a Fluorescent Dye - In a method for imaging a structure ( | 04-10-2014 |
20140097359 | IN-LINE DECAY-TIME SCANNER - The disclosed scanner allows detecting decay time characteristics of light emitted by a luminescent marking on an item which is transported, even at high speed, on a distribution/production line. The detection zone of the scanner's light sensor has a shape elongated along a path of the moving item, and the responsivity of the light sensor, within the wavelength range of the emitted luminescence light, is uniform over the detection zone. The control unit of the scanner is further operable to adapt the drive current, or drive voltage, powering its excitation light source to accordingly adapt the intensity of the excitation light delivered to the marking so that its light sensor can reliably measure the corresponding luminescence light response, and thus accurately determine a corresponding decay time value. | 04-10-2014 |
20140103226 | USE OF LUMINESCENT NANOSYSTEMS FOR AUTHENTICATING SECURITY DOCUMENTS - The present invention relates to the use of nanosystems as non deactivable security markers comprising metal atomic quantum clusters (AQCs) of at least two different size distributions encapsulated in a cavity with an inner diameter less than or equal to approximately 10 nm. These nanosystems are luminescence, particularly fluorescence after external excitation. The invention also relates to security documents, articles or elements incorporating these markers as well as to a method and a system for detecting the same. | 04-17-2014 |
20140117254 | APPARATUS FOR SUBSTANCE DETECTION - A sensing apparatus for detecting light of first and second fluorescent wavelength bands has a light source to generate an excitation wavelength to a first collimator element. A dichroic multiplexer has a first coated surface oblique to the optical axis and treated to transmit the excitation wavelength and to reflect the second fluorescent wavelength band and a second coated surface treated to transmit the excitation wavelength and the second fluorescent wavelength band and to reflect the first fluorescent wavelength band. A focusing element focuses the excitation light toward a light guide and directs collimated light of the first and second fluorescent wavelength bands from the light guide to the dichroic multiplexer. A first detector element is in the path of reflected light of the first fluorescent wavelength band and a second detector element is in the path of reflected light of the second fluorescent wavelength band. | 05-01-2014 |
20140117255 | SURFACE PLASMON-FIELD ENHANCED FLUORESCENCE SPECTROSCOPIC MEASUREMENT METHOD AND SURFACE PLASMON-FIELD ENHANCED FLUORESCENCE SPECTROSCOPIC MEASUREMENT DEVICE - To provide a surface plasmon-field enhanced fluorescence spectroscopic measurement method and a surface plasmon-field enhanced fluorescence spectroscopic measurement device which are capable of accurately measuring a fluorescent signal regardless of the type of a light detection means even when the concentration of an analyte is high by adjusting the dynamic range of the SPFS device. A surface plasmon-field enhanced fluorescence stereoscopic measurement method wherein an analyte labeled with a fluorescent substance is excited by surface plasmon light generated by applying excitation light to a metallic thin film, and generated fluorescence is received by a light detection means to thereby detect the analyte. The dynamic range is expanded by adjusting the amount of the fluorescence received by the light detection means. | 05-01-2014 |
20140117256 | APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE - In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter | 05-01-2014 |
20140124682 | Method for Optical 3D Measurement of Teeth With Reduced Point Spread Function - A 3D measurement of teeth occurs while exciting fluorescence in the volume of the teeth. To this end, use is made of suitable radiation which, as a result of the fluorescence, is therefore strongly absorbed. As a result of this, the problem of translucence when measuring teeth is significantly reduced. | 05-08-2014 |
20140131592 | IMAGE OBTAINING UNIT AND IMAGE OBTAINING METHOD - An image obtaining apparatus and an image obtaining method are provided. The image obtaining apparatus including a light source configured to generate excitation light causing a fluorescent label of a biological sample to emit light; an image sensor; an optical system configured to cause the image sensor to form a fluorescent image of the partial area of the biological sample; a movement control unit; a generation unit configured to continuously expose the image sensor during the movement of the focal position of the optical system, and to generate a long-time exposed image of the partial area; and a calculation unit configured to analyze a frequency of the generated long-time exposed image, and to calculate positional information in the optical axis direction of the fluorescent label by using at least results of the analysis. | 05-15-2014 |
20140131593 | METHOD FOR DETECTING FLUORESCENT PARTICLES - A method for detecting a fluorescent particle comprises the preparation of a sample solution containing fluorescent particles and a substance that promotes transition of the fluorescent particles from a triplet excited state to a singlet ground state, and calculation of the number of molecules of fluorescent particles present in the prepared sample solution. Calculation of the number of molecules of the fluorescent particles comprises moving the location of a photodetection region of an optical system in the sample solution using the optical system of a confocal microscope or multi-photon microscope, individually detecting fluorescent particles by detecting a light signal from the fluorescent particles present in the photodetection region while moving the location of the photodetection region in the sample solution, and counting the number of fluorescent particles detected during movement of the location of the photodetection region by counting the number of individually detected fluorescent particles. | 05-15-2014 |
20140145093 | STIMULATED EMISSION DEPLETION (STED) MICROSCOPY SYSTEM - The invention discloses an optical microscopy system ( | 05-29-2014 |
20140145094 | CARBON NANOTUBES WITH FLUORESCENT SURFACTANT - A fluorescent material may include a medium, carbon nanotubes dispersed in the medium, and a fluorescent surfactant. The fluorescent surfactant may be adsorbed to a surface of some of the carbon nanotubes in a concentration sufficient to make the material fluoresce in the presence of radiation. The material may be applied to a material and tested for fluorescence, electrical conductivity, or carbon nanotube structure. | 05-29-2014 |
20140151577 | Fluorescence Method for Determining Occlusion in Enclosed Spaces - A method of sensing scale build up on piping exposed to wellbore fluids, which includes the steps of sensing the build up of scale on the wall an injector pipe using fluorescence detection, generating a signal representative of the relative scale build up on injector pipe wall, and communicating that signal to a remote location. | 06-05-2014 |
20140151578 | SYSTEM AND METHOD FOR DETECTING DAMAGE TO A WIND TURBINE BLADE - A system and method of detecting damage to a wind turbine blade uses one or more fluorescent optical fibres comprising a fluorescent material having an excitation wavelength that is selected such that the material fluoresces upon exposure to ambient radiation at the wind turbine blade, wherein the one or more optical fibres are operatively mounted within the wind turbine blade such that upon damage to the wind turbine blade at least a part of the optical fibre is exposed at the surface of the blade causing the optical fibre to fluoresce; a light detector for receiving a light signal from one or from both ends of the one or more optical fibres upon excitation of the fluorescent material and outputting a signal based on the light signal; and a controller coupled to the light detector to receive the signal. | 06-05-2014 |
20140158912 | ULTRA DARK FIELD MICROSCOPE - A fluorescence microscope includes a nearly monochromatic light source, a Brewster angle wedge, and an optical system for irradiating a sample with a light beam from the light source and directing fluorescence light from said sample onto the Brewster angle wedge. Collection optics are provided for focusing a hyper-spectral, wide angle and dark field image of the sample from the Brewster angle wedge onto recording optics. | 06-12-2014 |
20140158913 | MICROPARTICLE ANALYSIS APPARATUS AND MICROPARTICLE ANALYSIS METHOD - There is provided a microparticle analysis apparatus including a light irradiation unit, which includes a plurality of light sources that emit laser light beams having different wavelengths, and which is configured to irradiate, with the laser light, microparticles flowing through a channel, and a light source drive control unit configured to control light emission by each light source in the light irradiation unit. The light source drive control unit is configured to supply a first current to each light source, and to supply in a time-division manner a second current to each light source while the first current is being supplied. | 06-12-2014 |
20140166904 | Efficient Fluorescence Detection In Solid State Spin Systems - Efficient fluorescence detection is achieved by optically guiding fluorescence light generated by color centers within a sample to photodetectors outside the sample. A fluorescence detection system may use a sample containing one or more fluorescence color centers that emit fluorescent light when irradiated with excitation light from an optical source. The sample has an index of refraction greater than its surrounding medium. The sample may include one or more output faces and further include at least two opposing faces configured to internally reflect the fluorescent light emitted by the fluorescent color centers, and to optically guide the emitted fluorescent light to the one or more output faces. The fluorescence detection system may include one or more optical detector configured to receive fluorescent light emitted through the one or more output faces, and a microwave source configured to manipulate the electronic spin of the fluorescent color centers. | 06-19-2014 |
20140175305 | Methods for Detecting Defects in Inorganic-Coated Polymer Surfaces - Lipophilic fluorescent substances can be used to detect surface defects in materials having hydrophilic (e.g., inorganic) coatings. Use of the described methods makes surface defects appear fluorescent, while the remaining surfaces are not labeled. The disclosed methods are inexpensive, rapid, and easy alternatives to existing approaches. | 06-26-2014 |
20140191139 | CONJUGATES OF NANO-DIAMOND AND MAGNETIC OR METALLIC PARTICLES - Techniques for imaging a characteristic of a sample with a plurality of conjugates of diamond-metallic nanoparticles having a nitrogen vacancy center. The plurality of conjugates can be exposed to a sample and the nitrogen vacancy centers can be optically pumped. One or more microwave pulses can be applied to the nitrogen vacancy center, and a fluorescent response can be detected. | 07-10-2014 |
20140197335 | METHODS, SYSTEMS AND DEVICES FOR DETECTING INSECTS AND OTHER PESTS - We describe a method for detection of the presence of an invertebrate or an invertebrate component in a sample of substantially non invertebrate material, comprising impinging said sample with a source of electromagnetic radiation at a wavelength of at least 600 nm and detecting Raman scattering/fluorescence of said invertebrate or a component of said invertebrate at a wavenumber where the non-invertebrate components of said sample either do not fluoresce or fluoresce with sufficiently low intensity wherein the non invertebrate material is edible and/or living. | 07-17-2014 |
20140203190 | OPTICALLY ACTIVE EPOXY - An optically active composition is described. The composition may include a copolymer of two or more polyepoxides covalently linked by a fused arene. | 07-24-2014 |
20140203191 | Method of Observing Samples with a Fluorescent Microscope - The invention relates to a method of inspecting parts of a sample on a TEM grid with a fluorescence microscope, as arises when performing correlative microscopy, more specifically for samples on a holey carbon grid. A problem occurs when imaging vitrified ice with sample material when the ice is heated by the light used. The invention is based on the insight that the absorption in the carbon support film is responsible for the heating, as ice hardly absorbs light. By localizing the illumination of the fluorescent microscope to the parts of the sample that are above a hole in the carbon, heating of the ice is lowered. The localization can be achieved by, for example, passing the light through a LCD type Spatial Light Modulator. | 07-24-2014 |
20140203192 | SYSTEMS AND METHODS FOR DISTINGUISHING OPTICAL SIGNALS OF DIFFERENT MODULATION FREQUENCIES IN AN OPTICAL SIGNAL DETECTOR - Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal. | 07-24-2014 |
20140209816 | SUPER-RESOLVED OPTICAL IMAGING APPARATUS AND OPTICAL IMAGING METHOD USING THE SAME - A super-resolved optical imaging apparatus and a super-resolved optical imaging method using the apparatus are disclosed. The optical imaging apparatus can includes: a light source unit configured to supply an incident beam; a nano-pattern chip having a plurality of nanostructures; a light adjustment system configured to change an incidence property of the incident beam in at least one of a horizontal direction and a depth direction such that surface plasmon resonance occurs in a localized area of the plurality of nanostructures; and an image detection unit configured to extract fluorescence signals generated by the surface plasmon resonance from a specimen positioned in the localized area and convert the fluorescence signals into an image. | 07-31-2014 |
20140231674 | INK JET PRINTER COMPOSITION AND USE - An aqueous ink jet printer ink composition is designed for ink jet printing of fluorescent images. This composition contains fluorescent pigment particles that have (1) an excitation peak wavelength of at least 300 nm and less than 400 nm, and (2) an emission peak that is greater than 400 nm and up to and including 700 nm when exposed to fluorescent-exciting radiation. The non-polymeric fluorescent pigment particles have a median particle size that is greater than 10 nm and up to and including 500 nm, and the 95 | 08-21-2014 |
20140231675 | Evaluation Circuit for an Optoelectronic Detector and Method for Recording Fluorescence Events - An improved evaluation circuit which allows high sensitivity in an economical manner. For this purpose, a shift register having at least one data input, a clock input, a plurality of register stages and at least one data output is provided, wherein the output of the analog-to-digital converter is connected to the data input of the shift register. With a shift register, fluorescent light and scattered light can be temporally distinguished in an economical manner. | 08-21-2014 |
20140239194 | METHOD FOR INSPECTING CONTACT BETWEEN MATING GEARS - A method for inspecting contact between mating gears that includes applying a mixture to teeth of a first gear, teeth of a second gear, or the teeth of both the first and second gears. The mixture includes a lubricating oil and a fluorescing dye. The first gear is rotated to drive the second gear. While the second gear is being driven by the first gear, electromagnetic radiation, such as ultra-violet radiation, is applied to the teeth of at least one of the first and second gears to cause the teeth to fluoresce. The fluorescing teeth of the second gear are inspected to identify a tooth inspection zone that approximates a zone of contact between the teeth of the first and second gears. | 08-28-2014 |
20140264078 | Radiation Image Read-Out and Cropping System - A system comprising a read out device for reading a radiation image stored in a photostimulable phosphor screen and for generating a digital signal representation of a read out image wherein the read out device supports a single format and is coupled to a processing unit which is programmed for cropping a region of interest (ROI) in the read out image. | 09-18-2014 |
20140264079 | Luminescent, Ultraviolet Protected Automotive Interior Members - A component of a motor vehicle comprising a photoluminescent interior member formed of a plastic composition, wherein the plastic composition comprises at least one polymer and a plurality of additives comprising at least one photoluminescent material and at least a first ultraviolet protector, wherein the at least one photoluminescent material absorbs electromagnetic radiation in a first ultraviolet range of an electromagnetic spectrum, and thereafter emits electromagnetic radiation in a visible radiation range of the electromagnetic spectrum, and wherein the first ultraviolet protector is an ultraviolet absorber, wherein the ultraviolet absorber absorbs electromagnetic radiation in a second ultraviolet range of the electromagnetic spectrum and does not absorb electromagnetic radiation in the first ultraviolet range of the electromagnetic spectrum. | 09-18-2014 |
20140264080 | PHASE-CHANGE ENABLED FLOW FIELD VISUALIZATION - A system and method for visualization of fluid flow, includes a light emitting arrangement configured to emit a focused light, a fluid channel configured to hold a fluid including a carrier liquid and a stimuli responsive polymer, wherein the fluid flows though the fluid channel, and an image recording arrangement. The light emitting arrangement is positioned to emit the focused light into a selected area of the fluid channel to interact with the flowing stimuli responsive polymer within the selected area. This results in a phase change to a portion of the stimuli responsive polymer. The image recording arrangement is positioned to record an image the portion of the phase changed stimuli responsive polymer made visible by the phase change. | 09-18-2014 |
20140264081 | REDUCING INCREMENTAL MEASUREMENT SENSOR ERROR - For position sensors, e.g., a fiber-based system, that build a shape of an elongated member such as a catheter using a sequence of small orientation measurements, a small error in orientation at the proximal end of the sensor will cause large error in position at distal points on the fiber. Exemplary methods and systems are disclosed which may provide full or partial registration along the length of the sensor to reduce the influence of the measurement error. Additional examples are directed to applying selective filtering at a proximal end of the elongated member to provide a more stable base for distal measurements and thereby reducing the influence of measurement errors. | 09-18-2014 |
20140264082 | FLUORESCENCE FLOW CYTOMETRY DEVICE AND METHOD - A flow cytometer including a laser, indexing structure, adjustment structure, and sensor structure. The cytometer is conventionally used with a removable microfluidic cassette, which is installed at a first position that is enforced by the indexing structure. The adjustment structure changes a relative position between an interrogation aperture of the cassette and the laser beam. Feedback from the sensor structure is used to optimize propagation of the laser through the interrogation aperture to reduce (and hopefully eliminate) autofluorescence caused by beam impingement onto the cassette. | 09-18-2014 |
20140291549 | Test Method for an Escape Route Marking - A testing method for an escape path marking which has an installation position and is illuminated by a light source located in a defined position relative to the installation position, in order to charge the escape path marking for achieving afterglow, | 10-02-2014 |
20140291550 | FLOW CYTOMETER SYSTEMS AND ASSOCIATED METHODS - A flow cytometer system for algal cells includes a flow cell having an interrogation region, a long wavelength illuminator for illuminating algal cells entering the interrogation region, and a short wavelength illuminator for exciting fluorescence within the algal cells. The system also includes one or more photodetectors for measuring the fluorescence, and a data acquisition system that detects the illuminated algal cells in the interrogation region. The data acquisition system controls the illuminators to provide specific timing and intensity conditions for stimulating to fluorescence, and acquires data from the one or more photodetectors to provide information of the algal cells. The system analyzes data at high speeds to allow it to sort cells based on fluorescence and scattering data. | 10-02-2014 |
20140291551 | METHODS AND SYSTEMS FOR DETECTING AND QUANTIFYING PETROLEUM OIL BASED ON FLUORESCENCE - Described herein are systems and methods for detecting and determining the presence and grade of petroleum oil in a sample. The methods and systems use the fluorescence produced by one or more transition metals present in the oil to detect and determine the presence and grade of the oil in the sample. The fluorescence produced by the metals is also useful as marker for tracking presence oil in the soil. The methods and offset the problems of the existing exploration technologies described above mentioned. Additionally, the methods and systems can be useful in identifying other compounds related to petroleum oil, such as carbon, hydrogen, and other types of aromatic compounds. | 10-02-2014 |
20140299787 | METHOD AND APPARATUS FOR ALIGNING MEASURED SPECTRAL RADIANCE FACTORS AMONG DIFFERENT INSTRUMENTS - Aligning measurements of fluorescent spectral radiance factors taken by a first instrument with measurements of fluorescent spectral radiance factors taken by a second instrument, without knowledge of the matrix of bispectral luminescent radiance factor of any sample, includes obtaining a fluorescent spectral radiance factor of a reference sample, measured by the first instrument, obtaining the fluorescent spectral radiance factor of the reference sample, measured by the second instrument, obtaining a fluorescent spectral radiance factor of a test sample, measured by the first instrument, and estimating the fluorescent spectral radiance factor of the test sample that would be measured by the second instrument, based on the fluorescent spectral radiance factor of a reference sample, measured by the first instrument, on the fluorescent spectral radiance factor of the reference sample, measured by the second instrument, and on the fluorescent spectral radiance factor of the test sample, measured by the first instrument. | 10-09-2014 |
20140306125 | METHOD AND APPARATUS FOR DETERMINING A RELAXATION TIME DEPENDENT PARAMETER RELATED TO A SYSTEM - A method for determining at least one parameter related to a system is disclosed, wherein the at least one parameter depends on at least one relaxation time of the system. The system is excited by a first series of electromagnetic excitation pulses, exhibiting a first defined time gap between consecutive excitation pulses. The response of the system to the first series of excitation pulses is integrated uninterruptedly over time, thus generating a first response signal. Likewise, by uninterrupted integration over time of at least one second response of the system, a second response-signal is generated. The at least one parameter is determined taking into account the first response-signal and the at least one second response-signal. | 10-16-2014 |
20140312247 | FLUORESCENCE IMAGER ON A MOBILE DEVICE - Systems and methods for substantially simultaneously exciting a fluorescently labeled specimen and capturing fluorescent light emitted therefrom using a smartphone, tablet, or similar mobile computing device, are disclosed herein. The system includes a light-emitting diode (“LED”) light source coupled with the smartphone to excite the specimen and an imaging device coupled with the smartphone to capture fluorescent light emitted from the specimen. The system further includes a hood adapted to be coupled with the smartphone that has an excitation filter configured to produce a first wavelength of electromagnetic radiation to strike the specimen when light from the LED light source passes through it and an emission filter configured to receive the light emitted from the specimen and to produce a second wavelength of electromagnetic radiation to be captured by the imaging device. | 10-23-2014 |
20140312248 | ARTICLES CONTAINING NON-VISIBLE IDENTIFYING MARKS FORMED FROM NANOMATERIALS AND METHODS UTILIZING THE SAME - Identifying marks are often used for authentication and tracking purposes with various types of articles, but they can sometimes be subject to replication or removal by an outside entity, such as a person or group having malicious intent. Carbon nanotubes and other carbon nanomaterials can be used to form identifying marks that are not visible to the naked eye, thereby making the marks more difficult for an outside entity to tamper with. Various articles can include an identifying mark that is not visible to the naked eye, the identifying mark containing a nanomaterial that includes a plurality of carbon nanotubes with a registered distribution of chiralities. The registered distribution of chiralities can be further tailored to increase the level of security provided by the mark. | 10-23-2014 |
20140319377 | PULSED STIMULATED EMISSION LUMINESCENT PHOTOVOLTAIC SOLAR CONCENTRATOR - A solar concentrator comprising: a light-transmissive sheet including: a plurality of luminescent particles capable of becoming excited by absorbing light within at least a first spectrum of absorption frequencies and, once excited, capable of being stimulated to emit light having a spectrum within at least a first spectrum of emission frequencies; and a first light-guide; and a light source for generating a pulsed probe light having a spectrum, at least a portion of which is within at least the first spectrum of emission frequencies, for stimulating at least one of the excited luminescent particles having absorbed light within the first spectrum of absorption frequencies such that when the probe light traveling in a first direction of travel stimulates the excited luminescent, the excited luminescent particles emit emitted light having a spectrum within the first spectrum of emission frequencies in the first direction of travel of the probe light. | 10-30-2014 |
20140319378 | OPTICAL FLUORESCENCE-BASED CHEMICAL AND BIOCHEMICAL SENSORS AND METHODS FOR FABRICATING SUCH SENSORS - An optical fluorescence-based sensor comprising at least one sensing element is disclosed. In one aspect, the at least one sensing element comprises a waveguide comprising a waveguide core, a light source optically coupled to an input part of the waveguide core, and a photodetector optically coupled to an output part of the waveguide core, the waveguide core being made of a material comprising a mixture of an optical material and a fluorescent dye. | 10-30-2014 |
20140319379 | MAPPING VOLUMES OF INTEREST IN SELECTED PLANES IN LIQUID SAMPLES - A method and apparatus for three dimensional fluorescent analysis of a target in a liquid sample having fluorescent analyte as a target substance or fluorescent label on the target substance. A rotating carousel carries liquid samples beneath a beam having a beam spot at a horizontal plane of the sample. The carousel advances slowly a linear direction during rotation so that a pattern of overlapping spiral scans provide R-theta two-dimensional samples of the entire plane to identify locations of volumes of interest where fluorescence is measurably higher than background. These locations are probed in the depthwise direction to find locations of fluorescent analyte in three dimensions. Light from the analyte or fluorescent label is detected and processed to characterize the target by color, size or other morphology. | 10-30-2014 |
20140326898 | Axial Illumination for Capillary Electrophoresis - System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. | 11-06-2014 |
20140326899 | Particulate Compositions Having Plural Responses to Excitation Radiation - A particulate composition comprises a plurality of particles wherein at least one of the particles comprises at least two different crystalline and/or glass phases, each phase comprising a host lattice and a dopant sensitive to electromagnetic radiation. The different phases simultaneously produce different responses on exposure to photons of the same energy, whereby the output from the particulate composition when exposed to said photons is the sum of the responses from the different phases. | 11-06-2014 |
20140332697 | METHOD OF DETECTING THALASSEMIA BY OPTICAL ANALYSIS OF BLOOD COMPONENTS - The method of detecting thalassemia by optical analysis of blood components is a spectral detection method that is based on the fluorescence spectra of a set of biomolecules, including tyrosine, tryptophan, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide, which are all found in blood plasma, and porphyrin, which is found in red blood cells (RBCs). Measured ratios of intensity maxima between tryptophan and nicotinamide adenine dinucleotide, flavin adenine dinucleotide and nicotinamide adenine dinucleotide, tyrosine and tryptophan, and the normal form of porphyrin and the basic form of porphyrin may each be used, alone or in combination, to diagnose a patient as suffering from thalassemia. | 11-13-2014 |
20140339438 | DEVICES AND METHODS FOR SPECTROSCOPIC ANALYSIS - The present invention relates to devices and methods for spectrometric analysis of light-emitting samples. The device comprises a particle beam source, which generates a primary particle beam directed to the sample in such a way that the primary particle beam is incident on the sample and photons are released from the sample due to the interaction between primary particle beam and sample material. Moreover, the device comprises a plurality of light-pickup elements, which are suitable for capturing the photons released from the sample, wherein the light-pickup elements capture the photons emitted in the respectively assigned solid-angle range. Furthermore, the device comprises conduction elements, which are embodied to forward captured photons to an evaluation unit, and an analysis system, which comprises a plurality of evaluation units in such a way that photons captured by each light-pickup element are analyzed spectrally. | 11-20-2014 |
20140339439 | Method for High-Resolution 3D Localization Microscopy - A method for high-resolution 3D localization microscopy, in which sample is used which has a boundary surface on the imaging side. The sample is illuminated with excitation light in order to excite fluorescence markers to emit light. The sample is imaged to a still image along an imaging direction, by means of imaging optics. The still image contains images of the fluorescing fluorescence markers. The imaging optics has a focal plane and an optical resolution. The excitation and imaging steps are repeated multiple times so that multiple still images are obtained. The excitation steps create images of at least a subset of the fluorescing fluorescence markers isolated in each of the still images. A location is determined in each of the still images and this location has a precision which is greater than the optical resolution. A high-resolution composite image is generated from the locations determined in this manner. | 11-20-2014 |
20140346371 | FLUORESCING GEL FORMULATIONS AND THEIR APPLICATIONS - Fluorescing gel formulations are disclosed for monitoring cleaning of a surface. The fluorescing gel formulations are stable, fluoresce under UV light, and do not leave a mark after drying and removal. The compositions include an oppositely charged complexing agent which is used in combination with an anionic or cationic optical brightener. In some embodiments, the compositions include a cationic optical brightener with no complexing agent. | 11-27-2014 |
20140353523 | METHOD FOR INSPECTING POLYSILICON LAYER - A method for inspecting a polysilicon layer includes: radiating excitation light to the polysilicon layer; and detecting a photoluminescence signal generated by the excitation light, wherein average power of the excitation light has a range of 1 W/cm | 12-04-2014 |
20140353524 | SYSTEM AND METHOD FOR DENSE-STOCHASTIC-SAMPLING IMAGING - Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images. | 12-04-2014 |
20140367590 | HIGH RESOLUTION LIGHT MICROSCOPE - The present invention relates to an apparatus for the optical analysis of a sample, also referred to as microscope, which is configured for an optical analysis process having high resolution for the detection of fluorescent molecules. The apparatus and the process applied when using the apparatus are configured for excitation light generated by an excitation light source to be directed onto a sample and the light emitted by the probe is detected. The apparatus and the process are characterized in that the excitation light is synchronized with the detection. The apparatus is characterized in that it has a polarization device which is configured to modulate the polarization of the excitation light with a modulation signal, wherein the modulation signal has or consists of at least one frequency, in particular a pre-determined frequency or several pre-determined superimposed frequencies, or the modulation signal consists of a sequence of signals that has no repetition. | 12-18-2014 |
20140367591 | MULTICOLOUR EXCITATION MODULE FOR A MULTIPHOTON IMAGING SYSTEM AND ASSOCIATED METHOD AND SYSTEM - A module is provided for a multi-photon imaging system for simultaneously exciting chromophores of a specimen. A first femtosecond laser source emits a first pulsed excitation beam having a repetition rate 1/T and a wavelength λ | 12-18-2014 |
20140374622 | System and Method for High Resolution, Instantaneous Wide Dynamic Range, Multi-Colour Luminescence Detection of Biological Samples in a Microfluidic System - The invention provides a high resolution, wide dynamic range, multi-colour detection platform for microfluidic analysers/instruments and methods. The detection platform uses multiple high gain semiconductor optical sensors for the detection of luminescence from cellular or biological samples. The digitized outputs from these sensors are combined and weighted in a signal processing unit, using pre-determined algorithms for each colour, which optimise the resolution in each of these high gain semiconductor optical sensors while extending the dynamic range of the detection platform. | 12-25-2014 |
20140374623 | METHOD AND APPARATUS FOR MEASURING OPTICAL PROPERTIES OF PARTICLES OF A DISPERSION - A method for measuring optical properties of particles of a flowable dispersion using a measuring cuvette. As the dispersion flows through the flow chamber of the cuvette, two laser light beams, offset 90 degrees to one another, illuminate the inner chamber of the cuvette and excite fluorescence in a particle. Regardless of the orientation of the particle, the total fluorescing light of the particle provides an accurate measurement of the contents of the cell and balances out form factor errors. | 12-25-2014 |
20150008340 | FLUORESCENCE OBSERVATION METHOD AND FLUORESCENCE OBSERVATION APPARATUS - A fluorescence observation method of the present invention for detecting plural types of fluorescence emitted from two or more kinds of fluorescent molecules includes: subjecting each of the two or more kinds of fluorescent molecules to multi-photon excitation by exciting light having an exciting wavelength equal to or shorter than 700 nm in a visible region, to generate fluorescence upon making use of an absorption wavelength band in a deep ultraviolet region of each of the two or more kinds of fluorescent molecules; and simultaneously detecting plural types of fluorescence generated on a shorter-wavelength side or on both of the shorter-wavelength side and a longer-wavelength side of the exciting wavelength of the exciting light. | 01-08-2015 |
20150021496 | METHOD TO ASSIST GEL ANALYSIS AND PROCESSING AND APPARATUS FOR THE SAME - A method to assist gel analysis and processing and apparatus for the same is disclosed. The method employs a tracing/marking/measuring/analyzing and referencing template of transparent sheet material comprising of a pattern made of vertical and horizontal lines that form quadrilateral shapes upon intersection. The vertical and horizontal lines are clearly visible in white light and ultraviolet light. The template sheet(s) can be inserted in a square shaped template holding assembly ( | 01-22-2015 |
20150028226 | OPTICAL UNIT, FLUORESCENCE DETECTION DEVICE, AND FLUORESCENCE DETECTION METHOD - Even when the distance from an objective lens to a sample differs, the distribution of light from the sample can be detected accurately. | 01-29-2015 |
20150034840 | FLUORESCENCE LIGHT DETECTION DEVICE AND FLUORESCENCE LIGHT DETECTION METHOD - A fluorescence light detection device includes an excitation light fiber having an excitation light emitting end configured to emit excitation light; a fluorescence light fiber having a fluorescence light incident end on which fluorescence light is incident; an objective lens arranged between where the excitation light emitting end and the fluorescence light incident end are located, and a sample; and a reflective member arranged between where the excitation light emitting end and the fluorescence light incident end are located, and the objective lens, and having two reflective surfaces facing in opposite directions. The two reflective surfaces of the reflective member are positioned between an optical axis of the excitation light fiber and an optical axis of the fluorescence light fiber. | 02-05-2015 |
20150041682 | Systems and Methods for Monitoring Phenanthrene Equivalent Concentrations - The present application is directed to systems methods and methods for monitoring phenanthrene equivalent concentrations in an aqueous stream. One or more sources of electromagnetic radiation at different wavelengths may be directed into a sample of the aqueous stream and the resulting fluorescence at various wavelengths is detected. The detected fluorescence is then used to determine the phenanthrene equivalent concentration. | 02-12-2015 |
20150053868 | VISUAL DETECTION OF MERCURY IONS - Composite materials comprising a mesoflower structure, methods of preparing the composite material, and methods of detecting heavy metal ion using the composite material are described herein. In some embodiments, a silica-coated gold mesoflower with a layer of silver quantum clusters may be capable of detecting Hg | 02-26-2015 |
20150053869 | INSPECTION APPARATUS AND INSPECTION METHOD - An inspection apparatus is an apparatus for inspecting a solar cell panel. The inspection apparatus includes: an excitation light irradiation part for irradiating the solar cell panel with pulsed light for causing the solar cell panel to radiate an electromagnetic wave pulse; a detection part for detecting the electromagnetic wave pulse radiated from the solar cell panel in response to irradiation with the pulsed light; and a temperature changing part for changing a temperature of the solar cell panel at a part irradiated with the pulsed light. | 02-26-2015 |
20150053870 | MULTI-FOCI LASER SCANNING MICROSCOPE AND USE OF SAME FOR ANALYZING SAMPLES - A multi-foci laser scanning microscope generates a set of time-multiplexed beams that are simultaneously scanned over multiple scan areas of the sample to be observed. A photodetector array associated with the beams detect fluorescence signals from the sample. A processor processes output signals from the photodetector array based on the time-multiplexing of the beams to provide a much wider field of view and reduced crosstalk between neighboring scan areas for more accurate imaging. | 02-26-2015 |
20150053871 | SYSTEM AND METHOD FOR TIME-RESOLVED FLUORESCENCE IMAGING AND PULSE SHAPING - A time-resolved fluorescence imaging (TRFI) system that images a target medium without lifetime fitting. Instead of extracting the lifetime precisely, the system images the fluorophore distribution to allow for a simple and accurate method to obtain the fluorescence image without lifetime-extraction for time-resolved fluorescence imaging. An illumination source circuit for TRFI is also disclosed that shapes the excitation pulse. In one embodiment, the illumination source comprises an LED and stub line configured for generating a linear decay profile. | 02-26-2015 |
20150053872 | APPARATUS AND METHODS FOR ANALYSING FLUORESCENT PARTICLES - According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least a detector having at least 100,000 active detection elements to detect a fluorescence signal from the sample. | 02-26-2015 |
20150060698 | FLUORESCENCE MICROTITRE PLATE READER - A fluorescence microtitre plate reader comprises a plate reader body ( | 03-05-2015 |
20150060699 | AUTHENTICATION SYSTEMS EMPLOYING FLUORESCENT DIAMOND PARTICLES - Authentication systems for products employing populations containing particles of diamonds that have fluorescent emissions of various wavelengths, intensities and durations are described. By varying the populations of diamond particles in products to be labeled, multiple different identification systems can be obtained permitting authentication taggants for large numbers of different products. | 03-05-2015 |
20150069267 | CONFOCAL IMAGING METHODS AND APPARATUS - The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis. | 03-12-2015 |
20150069268 | DEVICE AND METHOD FOR MULTI-PHOTON FLUORESCENCE MICROSCOPY FOR OBTAINING INFORMATION FROM BIOLOGICAL TISSUE - A device for multi-photon fluorescence microscopy for obtaining information from biological tissue has a laser unit for generating an excitation radiation, an optical unit implemented for focusing the excitation radiation for generating an optical signal at various locations in or on an object to be investigated, and a detector module for capturing the optical signal from the region of the object. The optical unit is thereby displaceable at least in one direction relative to the object for generating the optical signal at various locations in or on the object. The invention further relates to a method for multi-photon fluorescence microscopy. In said manner, a device and a method for multi-photon fluorescence microscopy are provided for obtaining information from biological tissue, allowing recording of section images in an object with a large field of view, and thereby are simply constructed and reliable in operation. | 03-12-2015 |
20150076365 | Signal Noise Reduction for Imaging in Biological Analysis - A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings. | 03-19-2015 |
20150083933 | MULTI-WAVELENGTH LED CURING LAMP - A curing device may comprise a first array of LED's, each LED of the first array emitting radiation substantially centered at a first excitation wavelength onto a quantum dot layer, the quantum dot layer positioned above the first array of LED's and configured to partially absorb the first excitation wavelength radiation and down convert the absorbed first excitation wavelength radiation, and partially transmit the emitted first excitation wavelength radiation, wherein the down converted and the partially transmitted first excitation wavelength radiation are directed onto a radiation-curable workpiece. | 03-26-2015 |
20150090902 | Method for Analyzing Mushrooms - The invention discloses a method for rapidly quantitative and qualitative analyzing active ingredients of mushrooms. The method for analyzing mushrooms uses a 3-D fluorescence-detecting system to analyze a sample of mushrooms, with an excitation wavelength and an emission wavelength being 250 nm and 310 nm, respectively. | 04-02-2015 |
20150102234 | SYSTEMS AND METHOD FOR FLUORESCENCE IMAGING - An apparatus for producing an image of blotting membranes includes an enclosure, light source, optical system, photodetector, and beamsplitter. The enclosure supports a blotting substrate comprising a first probe characterized by an excitation wavelength and an emission wavelength and a second probe characterized by an excitation wavelength and an emission wavelength. The light source directs diverging light to illuminate an entirety of the active area. The optical system forms an image of the entire active area and comprises an optical filter, the optical filter having an optical characteristic highly transmissive of light at the emission wavelengths and highly reflective of light at the excitation wavelengths. The beamsplitter may comprise an optical characteristic that is highly transmissive of light at the first and second emission wavelengths and that is highly reflective of light at the first and second excitation wavelengths. | 04-16-2015 |
20150108369 | SINGLE PARTICLE DETECTION DEVICE, SINGLE PARTICLE DETECTION METHOD, AND COMPUTER PROGRAM FOR SINGLE PARTICLE DETECTION, USING OPTICAL ANALYSIS - There is provided a single particle detection technique based on the scanning molecule counting method which individually detects single particles using light measurement with a confocal or multiphoton microscope, where the existences of a non-light-emitting particle and a light-emitting particle can be detected while being discriminated from one another in a sample solution. The inventive technique of detecting a single particle detects light from a light detection region during moving the position of the light detection region of the microscope in a sample solution containing a non-light-emitting particle and a light-emitting particle to generate time series light intensity data; and detects in the time series light intensity data a light intensity increase relative to background light intensity as a signal indicating the existence of the light-emitting particle and a light intensity reduction relative to the background light intensity as a signal indicating the existence of the non-light-emitting particle. | 04-23-2015 |
20150115175 | APPARATUS AND METHOD FOR SYSTEM IDENTIFICATION - Methods and apparatus for system identification operate by computing phase and amplitude using linear filters. By digitally processing the linearly filtered signals or data, the phase and amplitude based on measurements of the input and output of a system, are determined. | 04-30-2015 |
20150115176 | LASER SCANNING MICROSCOPE SYSTEM AND METHOD OF SETTING LASER-LIGHT INTENSITY VALUE - A method of setting a laser-light intensity value includes: emitting laser light, the laser light being excitation light, a fluorescent-dyed biological sample being irradiated with the excitation light and emitting light; detecting fluorescence emitted by the biological sample, and outputting a signal corresponding to a brightness value; prestoring relation information, the relation information including the plurality of laser-light intensity values, and information on at least one possible correlation between a phototoxicity degree and the brightness value in relation to each of the laser-light intensity values, the phototoxicity to the biological sample resulting from the laser light; generating a fluorescence image having the brightness value based on the output signal; calculating a brightness value representative of a ROI area based on the generated fluorescence image; and referring to the relation information, and determining a laser-light intensity value satisfying tolerance of the phototoxicity based on the calculated representative brightness value. | 04-30-2015 |
20150115177 | COLD-WORKED METAL ARTICLES INCLUDING LUMINESCENT PHOSPHOR PARTICLES, METHODS OF FORMING THE SAME, AND METHODS OF AUTHENTICATING THE SAME - Cold-worked metal articles, methods of forming cold-worked metal articles, and methods of authenticating cold-worked metal articles are provided. In an embodiment, a cold-worked metal article includes a cold-worked metal-containing surface that defines pores. The cold-worked metal-containing surface includes luminescent phosphor particles disposed within the pores. The luminescent phosphor particles include a host crystal lattice material and at least one active ion that includes an absorbing ion and an emitting ion that is different from the absorbing ion. The luminescent phosphor particles are harder than the cold-worked metal-containing surface. | 04-30-2015 |
20150123013 | Method and Apparatus for Investigating a Sample with Regard to the Lifetime of an Excited State - The invention relates to a method for investigating a sample with regard to the lifetime of an excited state, in particular a fluorescence lifetime, and/or with regard to a property of a sample which is correlated with a lifetime of an excited state, in particular with a fluorescence lifetime, a sample region being illuminated with a sequence of excitation light pulses. The method is characterized in that the light quantity and/or number of photons of the detected light, in particular fluorescent light, proceeding from the sample region is measured temporally between the excitation light pulses exclusively within a detection time window in each case, at least two detection time windows having different temporal lengths. | 05-07-2015 |
20150123014 | Determining Information for Defects on Wafers - Systems and methods for determining information for defects on a wafer are provided. One system includes an illumination subsystem configured to direct light having one or more illumination wavelengths to a wafer. The one or more illumination wavelengths are selected to cause fluorescence from one or more materials on the wafer without causing fluorescence from one or more other materials on the wafer. The system also includes a detection subsystem configured to detect only the fluorescence from the one or more materials or to detect non-fluorescent light from the wafer without detecting the fluorescence from the one or more materials. In addition, the system includes a computer subsystem configured to determine information for defects on the wafer using output generated by the detection subsystem responsive to the detected fluorescence or the detected non-fluorescent light. | 05-07-2015 |
20150129780 | MULTILAYER STRUCTURE - A multilayer structure contains a first security element, in particular a watermark or pseudo-watermark. A diffusing structure having a diffusing region that at least partially covers the first security element. A first luminescent layer at least partially covers the first security element and is capable of emitting a visible light of a first color when subjected to a predefined excitation radiation. The first luminescent layer extends between the first security element and the diffusing structure or the diffusing structure extends between the first security element and the first luminescent layer. In one variation, the first security element is observable in light transmitted through the multilayer structure when the structure is subjected to a predefined excitation radiation and/or in white light, only from the face of the structure situated on the same side as the first security element. | 05-14-2015 |
20150306893 | USE OF LUMINESCENT NANOCOMPOUNDS FOR AUTHENTICATING SECURITY DOCUMENTS - The present invention relates to the use of nanocompounds as non deactivable security markers comprising a charge-transfer complex of at least two different size metal atomic quantum clusters (AQCs). These nanocompounds are luminescent, particularly fluorescent after external excitation. The invention also relates to security documents, articles or elements incorporating these markers as well as to a method and a system for detecting the same. | 10-29-2015 |
20150308954 | METHOD OF SPATIAL HIGH RESOLUTION IMAGING OF A STRUCTURE OF A SAMPLE, THE STRUCTURE COMPRISING A LUMINOPHORE - For spatial high resolution imaging of a structure of a sample, the structure comprising a luminophore, the sample, in a measurement area, is subjected to an intensity distribution of luminescence inhibiting light comprising a local minimum. Then, the sample, in the measurement area, is subjected to luminescence excitation light which excites the luminophore out of an electronic ground state into a luminescent state, and luminescence light emitted out of the measurement area is registered. This registered luminescence light is assigned to the position of the local minimum within the sample. The luminescence inhibiting light disturbs the electronic ground state of the luminophore such that the luminophore, in the disturbed electronic ground state, has an absorption cross-section for the luminescence excitation light which is reduced by at least 50% as compared to the undisturbed electronic ground state. | 10-29-2015 |
20150308955 | METHOD OF SPATIAL HIGH RESOLUTION IMAGING OF A STRUCTURE OF A SAMPLE, THE STRUCTURE COMPRISING A LUMINOPHORE - For spatial high resolution imaging of a structure of a sample comprising a luminophore, the sample is subjected to excitation inhibiting light transferring the luminophore out of an excitable electronic ground state into a protection state in which the luminophore is protected against electronic excitation by luminescence excitation light and luminescence de-excitation light. The excitation inhibiting light comprises a first local minimum. Next, the sample is subjected to the luminescence excitation light exciting the luminophore within the first local minimum into an excited luminescent state. Then, the sample is subjected to the luminescence de-excitation light returning the luminophore out of the excited luminescent state into the excitable electronic ground state. The luminescence de-excitation light comprises a second local minimum overlapping with the first local minimum. Luminescence light emitted out of the measurement area is measured and assigned to the position of the second local minimum within the sample. | 10-29-2015 |
20150314630 | Security and/or value document having a type II semiconductor contact system - The invention relates to a security and/or value document having a security feature, to an ink for making the security feature, to a method for making such a security and/or value document, and to a method for verifying such a security and/or value document. | 11-05-2015 |
20150316480 | THERMOPHORESIS MEASUREMENTS IN NANOLITERDROPLETS - The present invention relates generally to a system and a method for thermo-optical measurements in a droplet of aqueous solution comprising particles of interest, the method comprising the following steps: providing the droplet of aqueous solution with a volume of less than 200 nl, wherein the aqueous solution is a first liquid and at least a part of the particles of interest are fluorescent particles; embedding the droplet of aqueous solution at least partly in a second liquid; irradiating a laser light beam into the droplet to obtain a spatial temperature distribution in the droplet around the irradiated laser light beam; exciting fluorescently said fluorescent particles and detecting fluorescence at least at one position or at around one position in the droplet or detecting the fluorescence distribution of said fluorescently excited particles, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and determining a characteristic of the particles of interest from the detected fluorescence intensity or fluorescence intensity distribution. | 11-05-2015 |
20150323458 | NONCONTACT RAPID DEFECT DETECTION OF BARRIER FILMS - A method of detecting a defect in a barrier film. The method includes: coating the barrier film with a solution having a plurality of probes, where each of the probes has a nanoparticle; forcing a probe of the plurality of probes to penetrate the defect by applying a field to the barrier film, where the field induces an attractive power to the nanoparticles of the probes; applying an optical excitation (OE) to the barrier film; and identifying the defect in the barrier film based on an optical signal emitted, in response to the OE, by the probe forced to penetrate the defect. | 11-12-2015 |
20150328915 | Value Document, Method for Checking the Presence of Same and Value Document System - The invention relates to a value document having luminescent, particulate agglomerates which respectively include at least two different, luminescent, solid homogeneous phases emitting at a first and a second emission wavelength, respectively, wherein upon an evaluation of measurement values that are obtainable by a measurement of the first luminescence intensity at the first emission wavelength and of the second luminescence intensity at the second emission wavelength, said measurement being location-specific and carried out at different locations, a statistical correlation is present between the first luminescence intensities and the second luminescence intensities. | 11-19-2015 |
20150344450 | SYNTHESIS, STRUCTURE AND USE OF FUNCTIONALIZED NAPHTHALENES - Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted. | 12-03-2015 |
20150346096 | SPECTRUM MEASURING DEVICE, SPECTRUM MEASURING METHOD, AND SPECIMEN CONTAINER - A spectral measurement apparatus for irradiating a sample as a measurement object with excitation light and detecting light to be measured includes a light source generating the excitation light; an integrator having an input opening portion through which the excitation light is input, and an output opening portion from which the light to be measured is output; a housing portion arranged in the integrator and housing the sample; an incidence optical system making the excitation light incident to the sample; a photodetector detecting the light to be measured output from the output opening portion; and an analysis device calculating a quantum yield of the sample, based on a detection value detected by the photodetector, and the excitation light is applied to the sample so as to include the sample. | 12-03-2015 |
20150355091 | Determining the Quantity of a Taggant in a Liquid Sample - Device and methods for detecting/quantifying a fluorescent taggant in a liquid sample. Generally, the liquid samples are fuels having low concentrations (measured in ppb) of a fluorescent taggant. The detection/quantification generates a predicted concentration of the fluorescent tagging compound using a process selected from the group of a multivariate process, a background subtraction process, or a combination of both. The invention addresses the detection of an adulteration of gasoline and diesel fuels. | 12-10-2015 |
20150355095 | METHOD FOR EVALUATING OXIDE SEMICONDUCTOR THIN FILM, AND METHOD FOR QUALITY CONTROL OF OXIDE SEMICONDUCTOR THIN FILM - This method for evaluating an oxide semiconductor thin film includes evaluating the stress stability of an oxide semiconductor thin film on the basis of the light emission intensity of luminescent light excited when radiating an electron beam or excitation light at a sample at which the oxide semiconductor thin film is formed. The stress stability of the oxide semiconductor thin film is evaluated on the basis of the light emission intensity (L1) observed in the range of 1.6-1.9 eV of the luminescent light excited from the oxide semiconductor thin film. | 12-10-2015 |
20150362430 | Method and Device for Determining a Concentration - The invention relates to a method and a device ( | 12-17-2015 |
20150362713 | RAPID ADAPTIVE OPTICAL MICROSCOPY OVER LARGE MULTICELLULAR VOLUMES - Excitation light is focused to a focus within a sample and the focus is scanned within a volume in the sample with scanning optical elements. Signal light emitted from the focus is de-scanned, with the one or more scanning optical elements, onto a wavefront sensor as the focus is scanned within the volume. Based on the descanned signal light, an average aberration created by the volume of the sample of a wavefront of the excitation light is determined. A wavefront of the excitation light is corrected by an amount according to the determined average aberration while the focus is scanned within the volume, the signal light is imaged onto a photosensitive detector as the focus is scanned within the volume, and a wavefront of the imaged signal light is corrected by an amount according to the determined average aberration while the focus is scanned. These steps can be repeated for a plurality of different volumes in the sample, and an image of the sample can be generated based on the detected signal light from scanned foci within the different volumes. | 12-17-2015 |
20160003730 | FLOW CYTOMETRY SYSTEM AND METHOD - A flow cytometry system having a flow channel defined through the thickness of a substrate is disclosed. Fluid flowing through the flow channel is illuminated by a first plurality of surface waveguides that are arranged around the flow channel in a first plane, while a second plurality of surface waveguides arranged around the flow channel in a second plane receive light after it has interacted with the fluid. The illumination pattern provided to the fluid is controlled by controlling the phase of the light in the first plurality of surface waveguides. As a result, the fluid is illuminated with light that is uniform and has a low coefficient of variation, improving the ability to distinguish and quantify characteristics of the fluid, such as cell count, DNA content, and the like. | 01-07-2016 |
20160003740 | Interferometric focusing of guide-stars for direct wavefront sensing - Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor. | 01-07-2016 |
20160003741 | APPARATUS AND METHODS FOR FLUORESCENCE IMAGING USING RADIOFREQUENCY-MULTIPLEXED EXCITATION - Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques. | 01-07-2016 |
20160003742 | TIME-RESOLVED LASER-INDUCED FLUORESCENCE SPECTROSCOPY SYSTEMS AND USES THEREOF - The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. | 01-07-2016 |
20160010802 | DAMAGE INDICATOR FOR A COMPOSIT PRESSURE TANK | 01-14-2016 |
20160011111 | COMPACT SYSTEMS, COMPACT DEVICES, AND METHODS FOR SENSING LUMINESCENT ACTIVITY | 01-14-2016 |
20160011113 | Method for the Operation of a Laser Scanning Microscope | 01-14-2016 |
20160011115 | Optical Systems and Methods for Biological Analysis | 01-14-2016 |
20160018332 | MEASURING APPARATUS AND FLUORESCENCE MEASURING METHOD - A low-noise fluorescence image and a low-noise luminescence image are acquired even if a luminescent substance having a high luminescence level is used. Provided is a measuring apparatus including an illumination optical system that radiates excitation light coming from an excitation light source onto a specimen A, an image acquisition portion that acquires an image by measuring light generated at the specimen, and an image processing portion that, based on a first image, which is acquired by the image acquisition portion without radiating the excitation light, and a second image, which is acquired by the image acquisition portion while radiating the excitation light, generates a fluorescence image by removing a luminescence component from the second image. | 01-21-2016 |
20160033407 | FLUOROMETER WITH MULTIPLE DETECTION CHANNELS - An optical sensor may have multiple detection channels to detect different characteristics of a fluid. For example, an optical sensor used in industrial cleaning and sanitizing applications may have multiple detection channels to detect when a system is both clean and properly sanitized. In one example, an optical sensor includes an optical emitter that directs light into a fluid, a first optical detector that detects light transmitted through the fluid, a second optical detector that detects light scattered by the fluid, and a third optical detector that detects fluorescent emissions emitted by the fluid. The optical emitter and optical detectors can be positioned around an optical analysis area. The optical sensor may include filters that control the characteristics of light detected by each of the optical detectors. | 02-04-2016 |
20160033409 | FLUORESCENCE INTENSITY ANALYZING AND FLUORESCENCE IMAGE SYNTHESIZING SYSTEM - A fluorescence intensity analyzing and fluorescence image synthesizing system and method are disclosed. The first fluorescence intensity detection device successively detects the plurality of first fluorescence intensities according to the first timing and the second fluorescence intensity detection device successively detects the plurality of second fluorescence intensities according to the second timing, and then the picture processing device analyzes the first and second timings and synthesizes the first and second fluorescence intensity ranges into the synthesized picture according to the fluorescence intensities, whereby the image processing technology may be used to calculate the fluorescence target range and thus mark the fluorescence target range. | 02-04-2016 |
20160033416 | METHOD OF CHECKING FORSTERITE, APPARATUS THAT EVALUATES FORSTERITE, AND PRODUCTION LINE THAT MANUFACTURES STEEL SHEET - The location where forsterite is present is checked in a region from which light excited by an electron beam is emitted when a material containing forsterite is irradiated with an electron beam. The material is preferably a grain oriented electrical steel sheet having a forsterite layer. In addition, it is preferable that the accelerating voltage be 10 kV or more when an electron beam is radiated when the material is a grain oriented electrical steel sheet having a tension coating layer on the forsterite layer. | 02-04-2016 |
20160041098 | FLUORESCENCE VIEWING DEVICE AND FLUORESCENCE VIEWING METHOD - A fluorescence viewing device is configured to take a difference between one of an image of a first frame and an image of a second frame output from an imaging device and the other of the first frame image and the second frame image stored in an image storage means, whereby clear observed images can be obtained without influence of background light. In the fluorescence viewing device, an exposure time of a fluorescence image acquisition period and an exposure time of a background image acquisition period are different from each other. Since ON/OFF durations of excitation light also become asymmetric according to the asymmetry of the exposure times, the device can reduce user's feeling of strangeness due to blinking of the excitation light. | 02-11-2016 |
20160041099 | LIGHT SHEET FLUORESCENCE AND DIFFERENTIAL INTERFERENCE CONTRAST MICROSCOPE - One or more excitation optical beams are scanned or otherwise directed to a specimen volume to establish a light sheet. Fluorescence from a specimen portion in the light sheet is collected and used to form an image. An interference contrast image of the same or an adjacent specimen portion is obtained by directing an interference contrast optical beam to the specimen so as to be substantially perpendicular to the light sheet. A common imaging device can be used to capture both images, and the resulting image permits correlation of fluorescence image features with specimen structure. | 02-11-2016 |
20160047746 | HANDHELD FLUOROMETER - A fluorometer for measuring fluorescence of a sample includes an excitation source for emitting electromagnetic radiation along a first beam path to induce fluorescence in the sample. An excitation filter transmits electromagnetic radiation from the excitation source toward the sample. An excitation filter holder supports the excitation filter and defines an aperture for passage of electromagnetic radiation from the excitation source. The aperture is positioned asymmetrically relative to the first beam path such that the aperture allows an asymmetrical portion of the electromagnetic radiation in the first beam path to pass toward the sample and the excitation filter holder blocks passage of a corresponding asymmetrical portion of the electromagnetic radiation in the first beam path. The blocked passage of the corresponding asymmetrical portion of the electromagnetic radiation in the first beam path reduces the amount of electromagnetic radiation oriented directly from the emitter module to the detector module. | 02-18-2016 |
20160053167 | FLUORESCING MCHM BLEND FOR FACILITATING DETECTION IN THE EVENT OF A SPILL - A 4-Methylcyclohexanemethanol and fluorescent dye blend. The fluorescent dye selected from a group consisting of a naphthalimide dye, a perylene dye, and combinations thereof. In one embodiment, the mixture includes a polyol ester oil, a petroleum hydrocarbon and a naphthalimide dye. The fluorescent dye may further comprise a mineral oil, and a perylene dye. | 02-25-2016 |
20160053168 | LIGHT UP-CONVERSION LUMINESCENT SUBSTANCE - [Problem] To provide a novel light up-conversion organic luminescent substance having a high light up-conversion efficiency. | 02-25-2016 |
20160054225 | ULTRA DARK FIELD MICROSCOPE - A fluorescence microscope includes a nearly monochromatic light source, a Brewster angle wedge, and an optical system for irradiating a sample with a light beam from the light source and directing fluorescence light from said sample onto the Brewster angle wedge. Collection optics are provided for focusing a hyper-spectral, wide angle and dark field image of the sample from the Brewster angle wedge onto recording optics. | 02-25-2016 |
20160054226 | An image forming method of a fluorescent sample - A method of imaging a fluorescent sample includes the steps of: scanning fluorescent points of the sample using a scanner apparatus, thereby obtaining scanned fluorescent points; and imaging the scanned fluorescent points on a display, the scanning including the steps of predefining a scan field for the sample, which includes a set of scannable fluorescent points; and sequentially irradiating, at least one first subset of points of the set of points and at least one second subset of the set of points, which complements the first subset with respect to the set of points. The first and second subsets can be irradiated at different focal irradiation distances. | 02-25-2016 |
20160054553 | METHOD AND DEVICE TO ACHIEVE SPATIALLY CONFINED PHOTOINTERACTION AT THE FOCAL VOLUME OF A MICROSCOPE - The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume ( | 02-25-2016 |
20160069808 | FLUORESCENCE IMAGING AUTOFOCUS SYSTEMS AND METHODS - Quantitative fluorescence imaging systems and methods using angular illumination to obtain automatic focus information. Laser scanning (e.g., point or line scanning) with angular illumination in combination with an area imaging sensor, such as with a bi-telcentric scanner, is used to determine sample height (relative to a detection axis orthogonal to a platform holding the sample) and also correct for sample height in subsequent scans. | 03-10-2016 |
20160075162 | SECURITY ELEMENTS EXHIBITING A DYNAMIC VISUAL MOTION - The present invention is related to a security element comprising a pattern of at least three layers, wherein a first layer comprises a first material which is capable of interacting with a first electromagnetic radiation but does not interact with a second and third electromagnetic radiation, a second layer comprises a second material which is capable of interacting with said second electromagnetic radiation but does not interact with a first and third electromagnetic radiation, and a third layer comprising a third material which is capable of interacting with a third electromagnetic radiation but does not interact with a first and second electromagnetic radiation, wherein said pattern provides a visual motion effect when exposed to a sequential illumination with a light source capable of separately emitting at least said first, second and third electromagnetic radiation. The present invention is furthermore related to the security element, the use of the security element for the protection of a security document against fraud or illegal reproduction, to a method for manufacturing the security element or security document, and to a method for creating a visual motion effect by sequential illumination of the security element. | 03-17-2016 |
20160077004 | CONJUGATES OF NANO-DIAMOND AND MAGNETIC OR METALLIC PARTICLES - Techniques for imaging a characteristic of a sample with a plurality of conjugates of diamond-metallic nanoparticles having a nitrogen vacancy center. The plurality of conjugates can be exposed to a sample and the nitrogen vacancy centers can be optically pumped. One or more microwave pulses can be applied to the nitrogen vacancy center, and a fluorescent response can be detected. | 03-17-2016 |
20160084763 | SYSTEM AND METHOD FOR EFFICIENT DETECTION OF THE PHASE AND AMPLITUDE OF A PERIODIC MODULATION ASSOCIATED WITH SELF-INTERFERING FLUORESCENCE - Systems and methods according to exemplary embodiments of the present disclosure can be provided that can efficiently detect the amplitude and phase of a spectral modulation. Such exemplary scheme can be combined with self-interference fluorescence to facilitate a highly sensitive depth localization of self-interfering radiation generated within a sample. The exemplary system and method can facilitate a scan-free depth sensitivity within the focal depth range for microscopy, endoscopy and nanoscopy. | 03-24-2016 |
20160097719 | METHODS FOR MONITORING ENVIRONMENTAL BARRIER COATINGS - A method of monitoring a surface temperature of an environmental barrier coating (EBC) of a hot gas component includes directing an excitation beam having a first wavelength at a layer of a temperature indicator formed on the hot gas component. The method also includes measuring a fluorescent radiation emitted by the temperature indicator. The fluorescent radiation has a second wavelength and an intensity. In addition, the method includes determining a surface temperature of the EBC based on the intensity of the second wavelength of the fluorescent radiation. | 04-07-2016 |
20160097720 | Method Of Determining The Suitability Of A Fuel For Use In An Engine And A Composition For Use In Such A Method - A method for determining the suitability for use in an engine of a fuel e.g. a jet fuel that may contain particulate contaminants, such as organic and/or inorganic particulates, is disclosed. The method can be used to distinguish a known organic particulate contaminant from inorganic particulate contaminants in the fuel. A composition suitable for use in the method is also disclosed. | 04-07-2016 |
20160103059 | FLUORESCENCE FLOW CYTOMETRY DEVICE AND METHOD - A flow cytometer including a laser, indexing structure, adjustment structure, and sensor structure. The cytometer is conventionally used with a removable microfluidic cassette, which is installed at a first position that is enforced by the indexing structure. The adjustment structure changes a relative position between an interrogation aperture of the cassette and the laser beam. Feedback from the sensor structure is used to optimize propagation of the laser through the interrogation aperture to reduce (and hopefully eliminate) autofluorescence caused by beam impingement onto the cassette. | 04-14-2016 |
20160108293 | INKS, COATINGS AND ADHESIVES AS CARRIERS FOR TAGGANTS FOR TOBACCO PRODUCT AUTHENTICATION AND COMPONENT DETECTION - Organic, fluorescent taggants and compositions thereof which find use in the production, detection and authentication of tobacco products and components thereof. A process for authentication of a tobacco product is also disclosed, the process including the steps of marking the tobacco product with a taggant composition comprising an organic, fluorescent taggant and a carrier for the taggant; irradiating the tobacco product with invisible radiation; and detecting fluorescence from the taggant. Adhesive and ink compositions are also disclosed. | 04-21-2016 |
20160109423 | MEASURING DEVICE FOR MEASURING A SURFACE LAYER ON AN OBJECT TO BE MEASURED, PARTICULARLY ON A FOODSTUFF - The invention relates to a measuring device ( | 04-21-2016 |
20160123863 | METHOD FOR DETECTING PARTICLES - The present invention concerns a method of detecting particles which move along a trajectory and which produce or at least influence electromagnetic radiation, an electrical field or a magnetic field, wherein the electromagnetic radiation S, the electrical field or the magnetic field is detected, in which a structuring device is used, which either ensures that the particles along the trajectory produce or at least influence electromagnetic radiation, an electrical field or a magnetic field substantially only at non-periodic spatial spacings, or ensures that the electromagnetic radiation S, the electrical or the magnetic field is detected substantially only at non-periodic spatial spacings along the trajectory. To provide a method of detecting particles which move along a trajectory and which produce or at least influence electromagnetic radiation, an electrical field or a magnetic field, it is proposed according to the invention that the detected signal S is processed by means of a mismatched filter F | 05-05-2016 |
20160123884 | FLUORESCENCE DETECTION DEVICE, SYSTEM AND PROCESS - An optical fluorescence analysis system ( | 05-05-2016 |
20160123885 | Inspection Lamp Having Reduction of Speckle of Laser Light - An inspection lamp for detection of fluorescent materials, such as dyes often added to refrigerant fluids for the purpose of detecting leaks. Multiple aspects of reducing a distracting speckle effect are described. For example, at least two aspects are combined. One speckle reduction aspect uses a diffuser. A second speckle reduction aspect is achieved by a laser device such as a laser diode that simultaneously outputs a large number of individual wavelengths across a significant bandwidth. A third aspect of despeckling the laser light includes vibrating or rotating optical components. A fourth aspect of despeckling includes fluorescence and broadband radiation from the laser being more visible through suitable eyewear than the laser radiation. | 05-05-2016 |
20160125682 | AUTHENTICATION SYSTEMS, AUTHENTICATION DEVICES, AND METHODS FOR AUTHENTICATING A VALUE ARTICLE - Methods are provided for authenticating a value article that includes a luminescent material. An exciting light source, an optical filter, a photodetector, a signal manipulation circuit, and an amplifier are provided. The luminescent material is exposed to light produced by the exciting light source. Radiation including light from the exciting light source and emitted radiation from the luminescent material is filtered using the optical filter to produce filtered radiation. The filtered radiation is detected using the photodetector to produce a detected radiation signal. The detected radiation signal is electronically manipulated using the signal manipulation circuit to reduce an effect of light from the exciting light source on an authentication determination based upon the detected radiation signal. The detected radiation signal is amplified with the amplifier after electronic manipulation to produce an amplified electronic signal. The amplified electronic signal or data derived therefrom is converted to an authentication output. | 05-05-2016 |
20160131598 | DETECTION SYSTEM FOR DETECTING A SOLDERED JOINT - The invention relates to a detection system ( | 05-12-2016 |
20160139048 | PHOTON EMITTER CHARACTERIZATION USING PHOTOLUMINESCENCE QUENCHING IN NITROGEN VACANCY COLOR CENTERS - A crystal film with nitrogen vacancy centers is placed in close proximity to a photon emitter. Excitation illumination is produced to cause the nitrogen vacancy centers to produce photoluminescence. Illumination is produced by the photon emitter, which may be near field or far field and which quenches the photoluminescence intensity using an effect known as Stimulated Emission Depletion (STED). The quenching caused by the photon emitter is detected and analyzed to determine characteristics of the photon emitter. The analysis takes into account the characteristic dependence of the STED on the depletion light power, i.e. the photon source, and a spatial distribution of the light intensity. The analysis may be applied to spatially resolved measurements or an integral value of the photoluminescence quenching. The analysis may determine characteristics such as peak power, power scaling factor, and FWHM of the illumination profile of the photon emitter. | 05-19-2016 |
20160140790 | METHOD AND DEVICE FOR MARKING VALUE LABELS - A method is provided for detecting value labels that have been re-used, that have a surface containing a luminescent substance, and that have been applied to mailpieces that are to be transported. These mailpieces pass through a sorting system in which the presence of value labels that have a surface containing luminescent particles which are distributed essentially evenly is checked. The mailpiece having such a surface is conveyed to a marking device. Here, the substrate in the form of the surface of the value label containing luminescent particles which are distributed essentially evenly is irradiated with high-energy radiation. In this process, wherever the radiation strikes the substrate, the luminescence of the particles is destroyed to such an extent that they are no longer detected as being luminescent when they pass through the sorting system once again. | 05-19-2016 |
20160146734 | METHODS OF DECREASING SCALE IN AQUEOUS SYSTEMS - Water-soluble polymers may be added to an aqueous system to inhibit or decrease scale deposition within the aqueous system. In a non-limiting embodiment, the water-soluble polymer(s) may be or include polymaleates, polyacrylates, copolymers thereof, and combinations thereof. The treated aqueous system may include a decreased amount of scale deposition as compared to an otherwise identical aqueous system absent the water-soluble polymer(s). | 05-26-2016 |
20160153909 | INSPECTION METHOD | 06-02-2016 |
20160161408 | METHOD FOR DETERMINING A VARIABLE OF A SAMPLE - A method for determining a variable of a sample is provided. At least one sensor substance is brought into contact with the sample and excited to luminesce by means of an electromagnetic excitation signal. The sensor substance is such that a relaxation time of its luminescence behavior depends on the variable of the sample to be determined. The electromagnetic excitation signal has a defined time-dependence, it is, for example, a frequency-modulated signal or a pulse sequence, in which distances between pulses are varied over the duration of the excitation signal. The time dependence of the luminescence response of the sensor substance is detected and an output signal is generated therefrom by integrating over specified time-intervals. An instant of time, relative to the time-dependence of the excitation signal, is determined, at which a step occurs in the time-dependence of the output signal. The value of the variable is determined from said instant of time. A preceding calibration can be advantageously used for this purpose. | 06-09-2016 |
20160178524 | LASER SCANNING MICROSCOPE SYSTEM AND METHOD OF SETTING LASER-LIGHT INTENSITY VALUE | 06-23-2016 |
20160187259 | STIMULATED EMISSION-DEPLETION (STED) MICROSCOPY BASED ON TIME GATING OF EXCITATION BEAM AND SYNCHRONOUS DETECTION OF FLUORESCENCE EMISSION - Method of optical microscopy by scanning a sample containing an excitable species, the method comprising: | 06-30-2016 |
20160202185 | SUB-DIFFRACTION LIMIT IMAGE RESOLUTION IN THREE DIMENSIONS | 07-14-2016 |
20160202462 | SYSTEM AND METHOD OF EDGE-ILLUMINATION MICROSCOPY | 07-14-2016 |
20160202606 | CORE-SHELL NANOPARTICLES, METHODS OF MAKING SAME, AND USES OF SAME | 07-14-2016 |
20160251369 | Azatriangulenium Salts As Pet-Quenched Fluorescent Probes | 09-01-2016 |
20160252456 | SINGLE PARTICLE DETECTION DEVICE, SINGLE PARTICLE DETECTION METHOD, AND COMPUTER PROGRAM FOR SINGLE PARTICLE DETECTION, USING OPTICAL ANALYSIS | 09-01-2016 |
20160252458 | QUANTUM DOT LIGHT EMITTING DIODES FOR MULTIPLEX GAS SENSING | 09-01-2016 |
20160377543 | INTEGRATED DEVICE FOR TEMPORAL BINNING OF RECEIVED PHOTONS - An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced. | 12-29-2016 |
20160377544 | METHOD AND APPARATUS FOR DETERMINING A DENSITY OF FLUORESCENT MARKERS IN A SAMPLE - The invention provides a method of determining a measure of a density of markers in a sample, and an apparatus arranged for performing said method. In particular said method comprising the steps of: | 12-29-2016 |
20160377545 | FLUORESCENCE BIOPSY SPECIMEN IMAGER AND METHODS - An imaging device is described that uses multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen. | 12-29-2016 |
20160377546 | MULTI-FOCI MULTIPHOTON IMAGING SYSTEMS AND METHODS - Multi-foci multiphoton imaging systems and methods are provided herein which advantageously implement an excitation system that avoids aberrations and a restricted field of view while utilizing a non-descanned detection system with interlaced scanning that reduces crosstalk and provides for improved imaging of tissue. The non-descanned detection system can employ a high-efficiency fiber coupled detection. | 12-29-2016 |
20160377547 | TIME-RESOLVED LASER-INDUCED FLUORESCENCE SPECTROSCOPY SYSTEMS AND USES THEREOF - The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific tens used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. | 12-29-2016 |
20160377548 | System and Method for Defect Detection and Photoluminescence Measurement of a Sample - Defect detection and photoluminescence measurement of a sample directing a beam of oblique-illumination wavelength light onto a portion of the sample, directing a beam of normal-illumination wavelength light for causing one or more photoluminescing defects of the sample to emit photoluminescent light onto a portion of the sample, collecting defect scattered radiation or photoluminescence radiation from the sample, separating the radiation from the sample into a first portion of radiation in the visible spectrum, a second portion of radiation including the normal-illumination wavelength light, and at least a third portion of radiation including the oblique-illumination wavelength light, measuring one or more characteristics of the first portion, the second portion or the third portion of radiation; detecting one or more photoluminescence defects or one or more scattering defects based on the measured one or more characteristics of the first portion, the second portion or the third portion of radiation. | 12-29-2016 |
20160377740 | APPARATUS AND METHOD FOR READING OUT STORAGE PHOSPHOR PLATES - An apparatus for reading out x-ray information stored in a storage phosphor plate includes an input device having a slot through which a cassette is inserted into the input device, the cassette configured to accommodate a storage phosphor plate, therein, and a read-out device that irradiates the storage phosphor plate with stimulation light and detecting emission light stimulated by the phosphor plate. The input device receives cassettes having different cassette widths, and the input device includes one or more first elements that align and/or fix the cassettes having different cassette widths in the input device, and/or one or more second elements that close the slot of the input device in order to prevent ambient light from passing through the slot when cassettes having different cassette widths are inserted into the input device. | 12-29-2016 |
20170231500 | SENSOR AND DEVICE FOR LIFETIME IMAGING AND DETECTION APPLICATIONS | 08-17-2017 |
20170233577 | NEAR INFRARED ABSORBING FLUORESCENT COMPOSITIONS | 08-17-2017 |
20170234762 | LEAKAGE OIL DETECTOR SYSTEM AND METHOD | 08-17-2017 |
20180024064 | METHOD OF DETECTING FIBROUS TISSUE IN A BIOLOGICAL SPECIMEN USING CO-LOCALIZED IMAGES GENERATED BY SECOND HARMONIC GENERATION AND TWO PHOTON EMISSION | 01-25-2018 |
20180024065 | OPTICAL DETECTION OF FLUORESCENCE | 01-25-2018 |
20180024338 | MULTI-FOCAL STRUCTURED ILLUMINATION MICROSCOPY SYSTEMS AND METHODS | 01-25-2018 |
20180024342 | APPARATUS AND METHOD FOR CONTROLLING A PLURALITY OF OPTICAL TRAPS | 01-25-2018 |
20180024345 | ILLUMINATION UNIT FOR DIGITAL PATHOLOGY SCANNING | 01-25-2018 |
20190145882 | Parallel Flow Cytometer Using Radiofrequency Multiplexing | 05-16-2019 |
20190145895 | Scanning Analyzer for Single Molecule Detection and Methods of Use | 05-16-2019 |
20220136047 | HIGH PERFORMANCE FLUORESCENCE IMAGING MODULE FOR GENOMIC TESTING ASSAY - Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the sample plane to capture a series of images (e.g., of different fields-of-view), and improved imaging system duty cycle, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications. | 05-05-2022 |