Entries |
Document | Title | Date |
20080203287 | MULTIPOLE DEVICES AND METHODS - The present invention provides, inter alia, a multipole ion guide for moving and guiding ions, particularly in a mass spectrometer. The multipole ion guide comprises multiple rods with a resistive coating, and radio frequency (RF) and direct current (DC) voltages applying to the resistive coating of each rod. Devices and systems comprising the multipole ion guide, as well as methods of use thereof, are also provided. | 08-28-2008 |
20080203288 | Multiple Ion Injection in Mass Spectrometry - This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions. | 08-28-2008 |
20080203289 | Use of Ionic Matrices For Maldi Mass Spectrometry Analysis of Tissue Sections - The invention concerns improved methods for studying peptides/proteins expression in a tissue section or for determining at least one compound, in particular a protein, expression map in a tissue section, using ionic MALDI matrices. | 08-28-2008 |
20080203290 | Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem - A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list. | 08-28-2008 |
20080203291 | Ion detection using a pillar chip - Methods and assemblies for ion detection in samples using a chip with elevated sample zones, also known as a “pillar chip.” Methods include analyzing such a sample by desorbing a sample from a chip, producing a described ion sample and detecting the same. The chip comprises a base having a surface and one or more structures protruding above the surface of the base. Each structure comprises a pillar and a sample zone, the latter containing a support material and the sample to be analyzed. Assemblies include a chip such as that described above and a conductive element that comprises an aperture of sufficient proportion to allow passage of a molecular ion and that is adapted to be at a different electrical potential than the base of the chip. | 08-28-2008 |
20080203292 | Mass spectrometer - An object of the present invention is to provide a mass spectrometer that uses a time-of-flight mass spectrometer for performing mass spectrometry on the basis of the difference in flight time based on mass of desired ions, and that is suitable for improving the sensitivity and analysis precision of the mass spectrometer. A gate electrode is located at a stage before an acceleration region that is located before an emitter for emitting ions. This gate electrode is capable of applying the voltage that is set on a mass-number region basis, and is also capable of separating desired ions to be measured on the basis of the mass number by switching the gate electrode at high speed. Therefore, it is possible to improve the resolution. | 08-28-2008 |
20080210855 | Method and Device for Determining the content of Lubricating Oil in an Exhaust Gas Mixture - The invention relates to a method for determining the lubrication oil content in an exhaust gas mixture comprising the steps of ionizing the exhaust gas mixture by means of an ion source ( | 09-04-2008 |
20080210856 | Fingerprinting of Complex Hydrocarbon Containing Mixtures - The invention provides a method of analysing a complex hydrocarbon-containing mixture, the method comprising the steps of: obtaining a liquid sample of the complex hydrocarbon-containing mixture; injecting the sample into a liquid carrier flowing to a mass spectrometer, wherein the mass spectrometer is set so as to ionise molecules in the sample without causing fragmentation thereof; recording a mass spectrum for ions obtained from the sample; and using the mass spectrum to obtain fingerprint of the mixture. {dot over (a)}In one embodiment, two or more mass spectra are recorded and are combined to obtain a fingerprint of the mixture. | 09-04-2008 |
20080210857 | Imaging mass spectrometer with mass tags - A method of analyzing biological material by exposing the biological material to a recognition element, that is coupled to a mass tag element, directing an ion beam of a mass spectrometer to the biological material, interrogating at least one region of interest area from the biological material and producing data, and distributing the data in plots. | 09-04-2008 |
20080210858 | High Stability Polyionic Liquid Salts - Polyionic liquid salts are provided comprising polycationic or polyanionic molecules. Further provided are solvents comprising one or more polyionic liquid salts, and the use of such polyionic liquid salts as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry (ESI-MS). | 09-04-2008 |
20080210859 | COAXIAL HYBRID RADIO FREQUENCY ION TRAP MASS ANALYZER - A coaxial hybrid ion trap that uses two substantially planar opposing plates to generate electrical focusing fields that simultaneously generate at least two different types or shapes of trapping regions, wherein a first trapping region is a quadrupole trapping region disposed coaxially with respect to the opposing plates, and wherein a second trapping region is a toroidal ion trap having a toroidal trapping region that is simultaneously created around the quadrupole trapping region. | 09-04-2008 |
20080217525 | Mass spectrometry and mass spectroscope - A magnetic field gradient is generated in a space, and a microparticle is flied downward in the space, thereby applying a magnetic force from the magnetic field gradient onto the microparticle. Then, a velocity and an acceleration of the microparticle due to the magnetic force are measured, thereby measuring a mass of the microparticle on the measured velocity and a magnetic susceptibility of the microparticle. | 09-11-2008 |
20080217526 | Metastable CID - Systems and methods of generating ions at atmospheric pressure are presented. These systems and methods include spatially dependent analysis of a sample using an effusive ionization source. Systems and methods of isolating samples at atmospheric pressure are presented. These systems and methods include using a barrier to prevent metastables or electrons from an effusive ion source from reaching a sample unless the sample is in an analysis position. Systems and methods of using metastables in collisionally induced dissociation are presented. | 09-11-2008 |
20080217527 | Chemical structure-insensitive method and apparatus for dissociating ions - In a method for exciting a precursor ion in an ion trap, the ion is trapped in a nonlinear trapping field that includes a quadrupolar field and a multipole field. The quadrupolar field is generated by applying a radio-frequency (RF) trapping voltage to the ion trap at a trapping amplitude and trapping frequency. A supplemental alternating-current (AC) voltage is applied to the ion trap at a supplemental amplitude and supplemental frequency. The supplemental amplitude is low enough to prevent ejection of the ion from the ion trap, and the supplemental frequency differs from the secular frequency of the ion by an offset amount. One or more operating parameters of the ion trap are adjusted, such that the ion absorbs energy from the supplemental field sufficient to undergo collision-induced dissociation (CID) without being in resonance with the supplemental field. | 09-11-2008 |
20080230687 | Automatic Analysis Device and Method for Monitoring Polymer Production by Means of Mass Spectroscopy - The invention relates to a method, which is used to monitor the composition of a polymer blend, melt and/or solution used to produce a polymer and to an automatic analysis device ( | 09-25-2008 |
20080230688 | Ion selector - The present invention provides an ion selector gate having a first deflection zone | 09-25-2008 |
20080230689 | CHEMICAL IDENTIFICATION OF PEROXIDE-BASED EXPLOSIVES - A method of detecting the presence of an analyte in an ion mobility spectrometer using an amide ionization reagent is provided. This method is particularly useful for the detection of peroxide-based explosives. | 09-25-2008 |
20080230690 | Method for analyzing minute amounts of Pd, Rh and Ru, and high-frequency plasma mass spectroscope used for same - The invention provides a method for analyzing minute amounts of Pd, Rh and Ru with high accuracy by a high-frequency plasma mass spectroscope. The method comprises (1) a step of pretreating a sample by an alkali fusion method using a sodium compound; and (2) a step of analyzing the pretreated sample using a high-frequency plasma mass spectroscope; wherein, in step (2), the distance between a sampling cone and a skimmer cone is adjusted such that the concentration of | 09-25-2008 |
20080237458 | AUTOMATED MASS SPECTRAL IDENTIFICATION - An automated or fully automated mass spectral system and a method of operating the system to identify a sample ion or compound. The system includes at least one computer addressable holder for at least one of standard and sample; at least one mass spectrometer configured to acquire one of continuum, profile, and raw mode mass spectral data; a computer system including a first software component to control introduction of at least one of the sample and the standard, data acquisition, and data analysis; a second software component for performing a mass spectral calibration involving at least m/z value, to report at least one of accurate mass, a list of possible elemental compositions, and a measurement statistic; and a third software component capable of acting on reported result or measurement statistic to change at least one of the introduction of at least one of the sample and the standard, data acquisition, data analysis, reported result, and measurement statistic. A computer readable medium having computer readable program code therein for use in the method or system. | 10-02-2008 |
20080251711 | Ultra High Mass Range Mass Spectrometer Systems - A mass spectrometer system includes an inlet system having an aerodynamic lens system for collimating charged particles into a beam, and an aerodynamic kinetic energy reducing device for receiving and slowing the charged particles to near zero kinetic energy. A detection system receives and identifies a mass of the charged particles. The aerodynamic kinetic energy reducing device can be a reverse jet or a pathway through a stagnant volume of gas. Such mass spectrometer systems can operate in a mass range from 1 to 10 | 10-16-2008 |
20080251712 | MEASUREMENT OF THE MOBILITY OF MASS-SELECTED IONS - The mobility of mass-selected ions in gases is measured at pressures of a few hectopascal by selecting the ions under investigation in a quadrupole filter according to their mass-to-charge ratio m/z, measuring their mobility in a drift region at a pressure of a few hundred Pascal under the influence of a DC electric field and then filtering the measured ions by means of a quadrupole field in order to eliminate, or detect changes in, the mass-to-charge ratio. Several embodiments for the drift region are disclosed, in which the ions are kept in the axis of the drift region by RF fields. As these drift regions can also be utilized for a collision-induced decomposition of the ions, the device can additionally be used as a so-called triple quadrupole mass spectrometer. | 10-16-2008 |
20080251713 | ION IMPLANTATION APPARATUS AND ION IMPLANTATION METHOD - An ion implantation apparatus according to the invention includes a park electrode as a deflecting apparatus arranged at a section of a beam line from an outlet of a mass analysis magnet apparatus to a front side of a mass analysis slit for deflecting an ion beam in a predetermined direction of being deviated from a beam trajectory line by an operation of an electric field. When the ion beam does not satisfy a desired condition, a park voltage is applied to the park electrode, thereby, the ion beam is brought into an evacuated state by being deflected from the beam trajectory line. As a result, the ion beam cannot pass through the mass analysis slit, and therefore, the ion beam which does not arrive at a wafer to prevent the ion beam which does not satisfy the condition from being irradiated to the wafer. | 10-16-2008 |
20080258052 | MASS SPECTROMETER INTERFACE - A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions. | 10-23-2008 |
20080272286 | Vacuum Housing System for MALDI-TOF Mass Spectrometry - The present invention is directed to ion source and vacuum housings for use in MALDI-TOF mass spectrometry which operates with any type of mass analyzer including linear, reflector, or tandem TOF-TOF instruments. By removing the requirement for the vacuum lock, the present invention allows operation of the ion source vacuum chamber at a pressure at least two orders of magnitude higher than conventional instruments. The present invention also requires only a single valve that isolates the ion source vacuum housing from the TOF analyzer vacuum housing. This is a significant improvement over vacuum locks in the art where the valve opening must be sufficiently large to allow the sample plate to pass through. | 11-06-2008 |
20080272287 | High Performance Low Cost MALDI MS-MS - The invention comprises apparatus and methods for rapidly and accurately determining mass-to-charge ratios of molecular ions produced by a pulsed ionization source, and for fragmenting all of the molecular ions produced and rapidly and accurately determining the intensities and mass-to-charge ratios of the fragments produced from each molecular ion. | 11-06-2008 |
20080277574 | Apparatus and Method For Positioning a Discharge Tube With Respect to an Orifice - Embodiments of the present invention facilitate servicing or changing a discharge tube or modifying the position of a discharge tube with respect to a orifice of a detector and/or a nebulizing gas conduit. The apparatus features a discharge tube housing that slidably receives a discharge tube. A union coupling the discharge tube to a source of fluid is slidably mounted to a mounting assembly holding the tube housing. | 11-13-2008 |
20080290267 | MCP unit, MCP detector and time of flight mass spectrometer - The present invention relates to an MCP unit or the like having a structure intended to achieve a desired time response characteristic, without depending on a limitation imposed by a channel diameter of MCP. The MCP unit comprises the MCP for releasing secondary electrons internally multiplied in response to incidence of charged particles, an anode arranged in a position where the secondary electrons reach, and an acceleration electrode arranged between the MCP and the anode. In particular, the acceleration electrode includes a plurality of openings which permit passing of the secondary electrons migrating from the MCP toward the anode. Further, the acceleration electrode is arranged such that the shortest distance B between the acceleration electrode and the anode is longer than the shortest distance A between the MCP and the acceleration electrode. Thus, an FWHM of a detected peak appearing in response to the incidence of the charged particles is remarkably shortened. | 11-27-2008 |
20080290268 | INFORMATION OBTAINING METHOD - An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass. | 11-27-2008 |
20080296485 | Method and Device for Mass Spectrometry Examination of Analytes - The invention relates to a method for the mass spectrometry examination of at least one analyte, wherein an analyte to be examined is photoionized and the mass of the ions produced is determined in a mass spectrometer. The analyte to be examined is ionized at normal atmospheric ambient pressure by means of laser light using multiphoton ionization, especially resonant multiphoton ionization. The invention also relates to a device which comprises an ionization chamber in which an analyte to be examined is ionized at normal atmospheric ambient pressure using resonant multiphoton ionization and is transferred into a mass spectrometer. Said device can be used as an interface between a device for the chromatographic or electrophoretic separation of analytes and a mass spectrometer. | 12-04-2008 |
20080296486 | METHOD FOR THE DETERMINATION OF THE POSITION OF UNSATURATION IN A COMPOUND - A mass spectrometric method for determining the position of unsaturation in a compound is disclosed. | 12-04-2008 |
20080302957 | IDENTIFYING IONS FROM MASS SPECTRAL DATA - A method for identify isotope patterns in mass spectral data, comprising obtaining a desired mass spectral peak shape function; obtaining mass spectral data composed of actual isotope patterns to be analyzed; calculating theoretical isotope pattern from known elemental composition of at least one basic ion whose isotope pattern is representative of the ions to be analyzed, by using mass spectral peak shape function; comparing quantitatively corresponding parts of the theoretical isotope pattern to that of the mass spectral data; calculating a numerical metric to measure similarity between the theoretical isotope pattern and actually measured isotope pattern; and utilizing the numerical metric as an indication for possible presence of ions whose isotope patterns resemble that of the basic ion. A computer for and a computer readable medium having computer readable code thereon for performing the methods. A mass spectrometer having an associated computer for performing the methods. | 12-11-2008 |
20080302958 | Mass Spectrometer - An ion trap mass analyser ( | 12-11-2008 |
20080308723 | METHOD OF NON-TARGETED COMPLEX SAMPLE ANALYSIS - A method for non-targeted complex sample analysis which involves the following steps. A first step involves providing a database containing identifying data of known molecules. A second step involves introducing a complex sample containing multiple unidentified molecules into a Fourier Transform Ion Cyclotron Mass Spectrometer to obtain data regarding the molecules in the complex sample with the identifying data of known molecules in order to arrive at an identification through comparison of the molecules in the sample. | 12-18-2008 |
20080315081 | Mass Spectrometry Precursor Ion Selection - The present invention is concerned with methods for the selection of precursor ions of a sample polypeptide for fragmentation in mass spectrometry, together with methods for determining at least one putative amino acid sequence for a sample polypeptide, apparatus and computer programs for same. | 12-25-2008 |
20090001262 | System and Method for Spectral Analysis - The system and method for spectral analysis uses a set of spectral data. The spectral data is arranged according to a second dimension, such as time, temperature, position, or other condition. The arranged spectral data is used in a signal separation process, such as an independent component analysis (ICA), which generates independent signals. The independent signals are then used for identifying or quantifying a target component. | 01-01-2009 |
20090008543 | MASS SPECTROSCOPY SYSTEM AND METHOD INCLUDING AN EXCITATION GATE - An ion extraction method and system includes: i) confining ions within an ion trap extending along a longitudinal axis; ii) exciting a subset of the ions to cause them to oscillate along at least one transverse coordinate; iii) after the transverse excitation, applying a first field and a second field in the region of the transverse excitation to move the excited ions towards one end of the ion trap and extract at least some of the excited ions at the end of the ion trap. | 01-08-2009 |
20090008544 | Methods for penning trap mass spectroscopy - A method of mass spectroscopy according to example embodiments may include injecting ions into a Penning trap and exciting the ions into cyclotron and/or magnetron motions. The cyclotron motions and magnetron motions may be converted to one another with external radio frequency signals. The ions may be ejected from the Penning trap onto a position sensitive charged particle detector to determine the phases and amplitudes of the motions. Ion cyclotron resonance frequencies may be determined based on the phases and amplitudes of the motions of the ejected ions. | 01-08-2009 |
20090014640 | Nebulizer with Nanometric Flow Rate of a Liquid Effluent and Nebulizing Installation Comprising Same - The invention concerns a nebuliser with nanometric flow rate of a liquid effluent in a nebulising gas comprising at least arranged substantially concentric, a capillary tube for intake of the liquid effluent and a nebulising needle including a central channel fed with liquid effluent through the capillary tube, a chamber for intake of the nebulising gas feeding a nozzle for expelling the nebulising gas, the nebulising needle passing through the intake chamber and the nozzle expelling the nebulising gas, the nebulising needle including a outlet for the liquid effluent whereof the aperture diameter is less than 20 ?m, the ratio of the diameter of the outlet of the nozzle expelling the nebulising gas and the outlet of the nebulising needle being more than 10 The inventive nanometric flow rate nebuliser and nebulising installation are applicable in mass spectrometry of trace elements contained in intracellular or microbiological medium for example. | 01-15-2009 |
20090014641 | Mass Spectrometer - A closed-loop ion guide ( | 01-15-2009 |
20090014642 | DATA ACQUISITION SYSTEM FOR A SPECTROMETER USING HORIZONTAL ACCUMULATION - A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for receiving, sampling, and processing ion detection signals received from the ion detector, and for supplying processed signals to the spectra processing module. The initial processing module includes a horizontal accumulation circuit that combines a fractional number of adjacent samples of the ion detection signals into bins. The number of adjacent samples to combine into bins may vary as a function of: (1) the time of arrival at the ion detector corresponding to that sample; (2) the mass corresponding to that sample; (3) the resolution corresponding to that sample; and/or (4) an operational mode of the spectrometer. The spectra processing module receives the processed signals and generates spectra. | 01-15-2009 |
20090020694 | ADIABATICALLY-TUNED LINEAR ION TRAP WITH FOURIER TRANSFORM MASS SPECTROMETRY WITH REDUCED PACKET COALESCENCE - A linear ion trap traps a plurality of charged particles in a charged particle trap including first and second electrode mirrors arranged along an axis at opposite ends of the particle trap, the electrode mirrors being capable, when voltage is applied thereto, of creating respective electric fields configured to reflect charged particles causing oscillation of the particles between the mirrors. The method includes: (a) introducing into the charged particle trap the plurality of charged particles, the particles having a spread in the oscillation time of the particles per oscillation; (b) applying voltage to the electrode mirrors during step (a) to induce a relatively weak self-bunching of the charged particles; and (c) after the plurality of charged particles has been introduced into the charged particle trap, waiting for a time period ΔT and then changing the voltage so as to induce a relatively stronger self-bunching among the charged particles. | 01-22-2009 |
20090026363 | PERFORMANCE ENHANCEMENT THROUGH USE OF HIGHER STABILITY REGIONS AND SIGNAL PROCESSING IN NON-IDEAL QUADRUPOLE MASS FILTERS - A quadrupole mass filter (QMF) is provided. The QMF includes a plurality of rectangular shaped electrodes aligned in a symmetric manner to generate a quadrupole field. An aperture region is positioned in a center region parallel to and adjacent to each of the rectangular shaped electrodes. An incoming ion stream enters the aperture region so as to be controlled by the quadrupole field. A plurality of voltage sources provide a r.f. and d.c. signal to the electrodes for generating the quadrupole field. An auxiliary voltage source applies an auxiliary drive signal to the r.f. and d.c. signal to create new stability boundaries within the standard Mathieu stability regions with high-resolution around operating conditions where there are approximately no higher-order resonances. | 01-29-2009 |
20090026364 | METHOD OF MEASURING TARGET OBJECT IN A SAMPLE USING MASS SPECTROMETRY - In-plane distribution of a target object contained in a sample is measured. The sample dispersedly placed on a substrate is treated to promote ionization of the target object. Then, the mass and flying amount of an ion containing the target object or a component thereof is determined by irradiating an ion beam to the sample and performing time-of-flight secondary ion mass spectrometry of the ion that flies from a portion in the sample where the ion beam is irradiated, and the in-plane distribution of the target object is determined from the mass and flying amount data obtained at plural portions by scanning the beam on the sample plane. The step of treating the sample to promote ionization of the target object includes contacting an aqueous solution of an acid that does not crystallize at ordinary temperature with the sample. A high spatial resolution two-dimensional image can be obtained. | 01-29-2009 |
20090032696 | METHOD AND APPARATUS FOR ION CYCLOTRON SPECTROMETRY - An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The spectrometer may also include means for producing a trapping electric field within the vacuum chamber that includes at least a first section that induces a first magnetron effect that increases a cyclotron frequency of an ion and at least a second section that induces a second magnetron effect that decreases the cyclotron frequency of an ion. The cyclotron frequency changes induced by the first and second magnetron effects substantially cancel one another so that an ion traversing the first and second sections will experience no net change in cyclotron frequency. | 02-05-2009 |
20090032697 | MASS ANALYZER AND MASS ANALYZING METHOD - There has been a problem that both detection sensitivity and throughput cannot be improved simultaneously by a conventional MS/MS analysis method. | 02-05-2009 |
20090032698 | MASS-ANALYSIS METHOD AND MASS-ANALYSIS APPARATUS - Among various ions introduced into an ion trap | 02-05-2009 |
20090032699 | ION MOBILITY SPECTROMETER AND METHOD FOR DETERMINING AN ANALYTE SUBSTANCE OR AN ANALYTE SUBSTANCE MIXTURE IN THE PRESENCE OF A DOPANT MIXTURE BY MEANS OF AN ION MOBILITY SPECTROMETER - The present invention pertains to a method for determining an analyte substance or analyte substance mixture of ammonia and/or N-methyl-2-pyrrolidone as a component of a gas in the presence of a dopant mixture by means of an ion mobility spectrometer and to a corresponding ion mobility spectrometer. | 02-05-2009 |
20090032700 | THREE-DIMENSIONAL RF ION TRAPS WITH HIGH ION CAPTURE EFFICIENCY - In a three-dimensional Paul RF ion trap at least one of the ring electrode and end cap electrodes is structured to produce a high capture efficiency for analyte ions introduced into the trap. The electrode structuring may be produced by an electrode surface profile having edges or protrusions, resulting in a scattering reflection of the introduced ions. Alternatively, at least one electrode may be formed by physically separate electrode components. In one embodiment, the trap can be switched between operating as a linear ion trap with good capture efficiency and operating as a three-dimensional ion trap with good ion reaction conditions. | 02-05-2009 |
20090032701 | DETECTION OF ANALYTES USING ION MOBILITY SPECTROMETRY - Methods and systems are provided for detecting analytes in a gas phase sample. An ion mobility spectrometer is provided for detecting analytes having an excess amount of dopant in its separation region. In an embodiment, the dopant is added directly to the separation region, such as with a drift gas or by diffusion, thereby providing excess dopant that dominates subsequent cluster formation and maintenance. Excess dopant in the separation region minimizes or reduces interfering signals associated with unwanted substances, such as water vapor, that are introduced to the IMS. In an aspect, the invention provides IMS systems and methods having increased sensitivity and reliability for analyte detection. | 02-05-2009 |
20090039245 | Mass Spectrometer - A Matrix Assisted Laser Desorption Ionisation ion source or ion imaging device is disclosed comprising a laser ( | 02-12-2009 |
20090039246 | METHOD FOR GENERATION AND USE OF ISOTOPIC PATTERNS IN MASS SPECTRAL DATA OF SIMPLE ORGANISMS - A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent. | 02-12-2009 |
20090039247 | METHOD FOR GENERATION AND USE OF STABLE ISOTOPE PATTERNS IN MASS SPECTRAL DATA - A composition adapted for mass spectral analysis is disclosed as are methods of its use in mass spectral analyses. A contemplated composition contains a mass spectrally-determinable amount of each of (i) at least one analyte to be assayed and (ii) a standard compound. Each of the molecules of the standard compound contains one or the other of a pair of two stable isotopes of the same element that differ in molecular weight by at least two atomic mass units. Those two isotopes are present in the molecules of the standard compound in a predetermined ratio that is other than the naturally occurring ratio of those isotopes. | 02-12-2009 |
20090045330 | Sample ionization at above-vacuum pressures - Sample material ionized in a sample receiving chamber is flowed into a sample conduit. Drying gas may also flow into the sample conduit and may be heated. The pressure and length of the sample conduit may be provided according to the product 50 or greater Torr-cm. The sample conduit may include a turn. The sample conduit may lead to an ion extraction chamber at which a sampling orifice may lead to a mass spectrometer. The diameter of the sample conduit may be larger than the diameter of the sampling orifice. An electrical field may be applied in the ion extraction chamber to slow incoming ions. A voltage jump may be applied to the sample conduit. | 02-19-2009 |
20090045331 | Solid-state flow generator and related systems, applications, and methods - The invention, in various embodiments, is directed to a method for analyzing a sample using a solid-state flow generator that provides a flow of effluent including the sample through an ion mobility based filter. | 02-19-2009 |
20090050798 | Method for Sequencing Peptides and Proteins Using Metastable-Activated Dissociation Mass Spectrometry - Methods for fragmentation of large molecular ions, including proteins, nucleic acids, dendromers, and nanomaterials, compatible with several mass spectrometric techniques. The methods involve providing a gas-phase ion and allowing the gas phase ion to undergo collisions with metastable states of noble gases or nitrogen gas. | 02-26-2009 |
20090057546 | MASS SPECTROMETER | 03-05-2009 |
20090057547 | MASS SPECTROMETER - A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Q | 03-05-2009 |
20090057548 | Electron multiplier having electron filtering - A system for detecting ions is disclosed. The system includes a detector having a plurality of dynodes arranged in an electron cascading configuration, and a power supply circuit electrically coupled to the plurality of dynodes. The plurality of dynodes include a first dynode and a second dynode. The power supply circuit is arranged to selectively adjust a potential difference between the first and second dynodes between a detection mode and a blanking mode. A method of detecting ions is also disclosed. | 03-05-2009 |
20090057549 | Method of Excising Sugar Chain from Glycoprotein, Method of Mass Spectrometry of Sugar Chain, and Method of Mass Spectrometry of Glycoprotein - The present invention provides a method of enzymatic reaction on a membrane by a sugar chain releasing enzyme, for an MALDI-TOF MS analysis of a glycoprotein that is solid-phased on a membrane is conducted directly on the membrane; a method of mass spectrometry of a sugar chain in which a sugar chain, for the MALDI-TOF MS analysis of a sugar chain excised from a glycoprotein that is solid-phased on a membrane is conducted directly on the membrane; and a method of mass spectrometry of a glycoprotein, for the MALDI-TOF MS analysis of a glycoprotein of a glycoprotein that is solid-phased on a membrane is conducted directly on the membrane. A method of excising a sugar chain to obtain excised sugar chains by excising the sugar chains by dispensing a sugar chain releasing enzyme solution on a glycoprotein that is solid-phased on a carrier, wherein the sugar chain releasing enzyme solution is a solution containing a sugar chain releasing enzyme in a reaction buffer solution containing a buffering agent consisting essentially of a volatile component. A method of mass spectrometry of a sugar chain and a method of mass spectrometry of a glycoprotein using the method of excising the sugar chain. | 03-05-2009 |
20090057550 | SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS - A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. | 03-05-2009 |
20090065688 | ANALYTICAL INSTRUMENT - The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique. | 03-12-2009 |
20090065689 | MASS ANALYSIS USING ALTERNATING FRAGMENTATION MODES - A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Transfer Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Transfer Dissociation fragmentation device. | 03-12-2009 |
20090065690 | MASS ANALYSIS WITH ALTERNATING BYPASS OF A FRAGMENTATION DEVICE - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer. | 03-12-2009 |
20090065691 | High throughput quadrupolar ion trap - A method and apparatus are provided for operating a linear ion trap. A linear ion trap configuration is provided that allows for increased versatility in functions compared to a conventional three-sectioned linear ion trap. In operation, the linear ion trap provides multiple segments, the segments spatially portioning an initial population of ions into at least a first and a second ion population. Each segment is effectively independent and ions corresponding to the first ion population are able to be manipulated independently from ions corresponding to ions corresponding to the second ion population; the ions having been generated by an ion source under the same conditions. The ions can then be expelled from the ion trap. | 03-12-2009 |
20090072132 | MASS SPECTROSCOPY SYSTEM AND MASS SPECTROSCOPY METHOD - An inexpensive mass spectrometer system is provided. This mass spectrometer is capable obtaining structural information of a substance at an improved efficiency, and the time required for the analysis and identification of the substance has been reduced. Identification precision has also been improved. More specifically, this invention provides a tandem mass spectrometer system in which the sample is ionized at the desired polarity, fragment ions obtained by dissociating the ion is analyzed in first or second mass spectrometer section, polarity of the second mass spectrometer is determined based on the result of the analysis, and the mass spectroscopy is carried out. A method for the mass spectroscopy is also provided. | 03-19-2009 |
20090072133 | MULTI-BEAM ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETER WITH BIPOLAR ION EXTRACTION AND ZWITTERION DETECTION - The present invention relates generally to instrumentation and methodology for the characterization of chemical samples in solutions or on a surface which is based on modified ionization methods with or without adjustable pH and controllable H-D exchange in solution, an improved ion mobility spectrometer (IMS), a multi-beam ion pre-selection of the initial flow, and coordinated mobility and mass ion separation and detection using a single or several independent time-of-flight mass spectrometers for different beams with methods for fragmenting ion mobility-separated ions and multi-channel data recording | 03-19-2009 |
20090072134 | Data Acquisition System for a Spectrometer Using Various Filters - A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The spectra processing module generates spectra from the processed signals and supplies the generated spectra to an external processor for post-processing. The spectra processing module may include one or more of: a cross-spectra filter for filtering data in each spectra as a function of data in at least one prior spectra; a shaping filter for removing skew and shoulders from the processed signals; a sharpening filter for sharpening the peaks of the processed signals to effectively deconvolve and separate overlapping peaks; an ion statistics filter; and a peak histogram filtering circuit. | 03-19-2009 |
20090078861 | Ion Mobility Spectrometry Method and Apparatus - The invention includes an ion mobility spectrometer having a liquid filled drift chamber. The chamber has an ionization region partitioned from and an ion separation region by a reversible ion-migration block. An electrical field within the chamber allows ions to migrate toward the electrode collector. Passage of ions from the ionization region is triggered by reversing the block allowing ions to migrate into the ion separation region. The invention includes a method of ion mobility analysis in liquid phase. Ions are mobilized to migrate through a drift liquid and are detected at an end of a drift chamber. The invention also includes a method of generating ions in a sample. A sample containing molecules in a first solvent is introduced into a second solvent through a charged capillary where the electrically charged sample is electro-disperses to ionize the molecules. | 03-26-2009 |
20090078862 | ION MOBILITY SPECTROMETRY ANALYZER FOR DETECTING PEROXIDES - The present invention provides IMS analyzers and methods for detecting, identifying, and characterizing (e.g., measuring the concentration of) peroxides in samples. Methods and systems of the present invention utilize sample inlet conditions and dopant strategies providing an enhancement in selectivity and sensitivity for the detection of peroxide compounds relative to conventional IMS analyzers. Dopants of the present invention include, but are not limited to, substituted aryl compounds or substituted cyclic dienes; wherein the substituted aryl compound or the substituted cyclic diene has at least one substituent selected from the group consisting of a hydroxyl group, a carbonyl group, an aldehyde group, an ester group, a carboxylic acid group and a carbonate ester group. The present IMS analyzers and methods are versatile and enable selective detection of a broad class of peroxides and derivatives thereof, including hydrogen peroxide, hydroperoxides, organic peroxides and derivatives thereof. | 03-26-2009 |
20090078863 | Determination Of Chemical Empirical Formulas Of Unknown Compounds Using Accurate Ion Mass Measurement Of All Isotopes - A method of determining an empirical formula of an analyte ion from a measured mass spectrum including a main peak and one or more isotope peaks. The method comprises comparing a relative isotopic intensity of the measured isotope peak to a calculated relative isotopic intensity of an isotopic ion of a proposed empirical formula and comparing a relative mass defect of the measured isotope peak to a calculated relative mass defect of the isotopic ion of the proposed empirical formula. The proposed empirical formula is identified as a potential candidate for the analyte ion based on these comparisons. | 03-26-2009 |
20090084948 | OVERCOMING SPACE CHARGE EFFECTS IN ION CYCLOTRON RESONANCE MASS SPECTROMETERS - In an ion cyclotron resonance mass spectrometer in which ions are trapped axially by applying electrical potentials to a pattern of electrode elements to produce an inhomogeneous alternating radio-frequency electric field with a repulsive effect, an additional electrostatic ion-attracting field is superimposed on the repulsive electric field. The voltage of the ion-attracting field is adjusted to compensate for a cyclotron frequency shift of the ions caused by the ion space charge. The voltage of the ion-attracting field can be adjusted so that the ion cyclotron frequency of all ions becomes independent of the number of ions inside the spectrometer. | 04-02-2009 |
20090084949 | EVALUATION OF SPECTRA IN OSCILLATION MASS SPECTROMETERS - The invention relates to mass spectrometers in which ion clouds are stored in two spatial directions by radial forces while oscillating largely harmonically at a mass-specific frequency in a third spatial direction perpendicular to the other two, in a potential minimum, the shape of which is as close to a parabola as possible. Analysis of the oscillation frequencies of these ion clouds, preferably by a Fourier analysis, leads via a frequency spectrum to a mass spectrum. The frequency spectrum is analyzed to identify false signals in the frequency spectrum as harmonics and eliminating them where necessary. | 04-02-2009 |
20090084950 | Apparatus for detecting chemical substances and method therefor - An apparatus for detecting chemical substances which is high in sensitivity and selectivity is provided. | 04-02-2009 |
20090090853 | HYBRID MASS SPECTROMETER WITH BRANCHED ION PATH AND SWITCH - A hybrid mass spectrometer has a branched ion path. A first ion path within the branched ion path operates as a triple quadrupole instrument having a mass selection device, collision cell, and first mass analyzer and provides information on a specific m/z ratio corresponding to ions of interest in a sample. A second ion path within the branched ion path includes a second mass analyzer in the form of an electrostatic trap or other ion trap device. A branched ion transfer device may provide the branched ion path and may include the collision cell. A controller actuates an ion path switch in the branched ion transfer device and diverts from the first ion path to the second ion path in response to a triggering event. Ions at or near the m/z ratio of interest are then analyzed in the trap to obtain more detailed information of a full spectrum. | 04-09-2009 |
20090090854 | Mass Spectrometer and Method of Using the Same - A mass spectrometer is provided which is mounted on a wall portion of a chamber and analyzes a gas to be analyzed existing in the chamber. The mass spectrometer includes: a measurement unit which is inserted into the chamber at the time of mounting the mass spectrometer to the chamber and measures each partial pressure of gaseous components in the gas to be analyzed with respect to mass-to-charge ratios; a control unit which is disposed outside of the wall portion at the time of mounting the mass spectrometer on the chamber and is used to manipulate the measurement unit; and a display unit which is disposed outside of the wall portion at the time of mounting the mass spectrometer on the chamber and displays the measurement result of the measurement unit. Here, the measurement unit, the control unit, and the display unit are disposed close to each other. | 04-09-2009 |
20090090855 | PREPARATION OF SAMPLES FOR LC-MS/MS USING MAGNETIC PARTICLES - The present invention provides a novel procedure of preparing samples for analysis by way of mass spectrometry, preferably LC-MS/MS. Accordingly, functionalized magnetic particles with a hydrophobic surface were used for extracting low molecular weight compounds from complex liquid biological samples such as plasma, serum, whole blood or hemolyzed blood. The method of the invention includes (a) contacting the sample with an amount of functionalized magnetic particles with a hydrophobic surface, (b) incubating the sample and the particles, thereby adsorbing the compound to the hydrophobic surface, (c) separating the particles by applying a magnetic field and removing the liquid, (d) optionally washing the particles, (e) eluting the compound from the particles. | 04-09-2009 |
20090090856 | Methods and systems for quantification of peptides and other analytes - Disclosed are LC-LC-MS/MS techniques for the analysis of endogenous peptides and other highly polar small molecules. The methods and systems of the present invention can be applied in all industries that utilize LC-MS/MS for the evaluation and quantification of biological analytes in complex matrixes. | 04-09-2009 |
20090090857 | Systems and Methods for Identifying Substances Contained in a Material - In one embodiment, a system and a method relate to generating a summed ion spectrum for a test sample, the summed ion spectrum identifying ion intensities at multiple different mass-to-charge ratios, and comparing the summed ion spectrum of the test sample with multiple reference summed ion spectra to identify a potential match. | 04-09-2009 |
20090090858 | SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY - In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled. | 04-09-2009 |
20090090859 | High density cast-in-place sample preparation card - A card or insert having a plurality of recesses for a sample preparation device, the card containing cast-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular card size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a plurality of recesses in an insert for a multi-well sample preparation device, thereby providing an effective platform for high throughput micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted in multiplicity, including selective bind/elute chromatography, operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. Manufacturing flexibility and high throughput is achieved. The card can be configured for direct analysis of bound sample without elution. | 04-09-2009 |
20090095897 | Sample target used in mass spectrometry, method for producing the same, and mass spectrometer using the sample target - In one embodiment of the present invention, a sample target that allows ionization of a substance whose molecular weight is so high as to exceed 10000 in mass spectrometry that ionizes a sample without using matrix, a method for producing the same and a mass spectrometer using the sample target. The sample target includes a sample support surface including a large number of fine pores on its face receiving irradiated laser light. Each of the fine pores has a diameter of 30 nm or more and 5 μm or less. The number indicative of pore depth/(pore cycle−pore diameter) of each of the fine pores is 2 or more and 50 or less. The face of the sample support surface is coated with metal or semiconductor. | 04-16-2009 |
20090095898 | Collision cell for mass spectrometer - A novel curved collision cell for a mass spectrometer is described. The collision cell includes a straight section having a length that is selected to cause a precursor ion entering the straight section to lose a desired amount of kinetic energy such that when the precursor ion enters the curved section of the collision cell the precursor ion will tend to neither escape nor contact the collision cell, and thereby tending to survive its passage within the curved portion. | 04-16-2009 |
20090095899 | ATMOSPHERIC PRESSURE ION SOURCE PERFORMANCE ENHANCEMENT - Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ion signal amplitude generated in Electrospray and detected by a mass spectrometer (MS) Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal New Electrolytes have been found that increase positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. It has also been found that running the ES membrane probe with specific Electrolytes in the second solution of the ES membrane probe have been found to enhance ESMS signal compared to using the same electrolytes directly in the sample solution being Electrosprayed The new electrolytes can be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency. | 04-16-2009 |
20090095900 | ATMOSPHERIC PRESSURE ION SOURCE PERFORMANCE ENHANCEMENT - Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications. Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as H+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ion signal amplitude generated in Electrospray and detected by a mass spectrometer (MS) Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. New Electrolytes have been found that increase positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. It has also been found that running the ES membrane probe with specific Electrolytes in the second solution of the ES membrane probe have been found to enhance ESMS signal compared to using the same electrolytes directly in the sample solution being Electrosprayed. The new electrolytes can be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency. | 04-16-2009 |
20090101810 | MULTIPLEX DATA ACQUISITION MODES FOR ION MOBILITY-MASS SPECTROMETRY - A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms. | 04-23-2009 |
20090101811 | METHOD OF AND APPARATUS FOR ANALYZING IONS ADSORBED ON SURFACE OF MASK - A method of analyzing ions adsorbed on a surface of a mask for pattern formation of a semiconductor device, and an apparatus using the same are disclosed. The ion analyzing method includes: filling a heating container within a main chamber with a predetermined amount of a solvent; immersing a mask in the solvent-filled heating container; raising an internal pressure of the chamber to a predetermined level by supplying gas into the chamber; separating ions from a surface of the mask by heating the solvent within the heating container at a predetermined temperature for a predetermined period; and analyzing the ions by collecting the solvent. | 04-23-2009 |
20090101812 | INTERFACE BETWEEN DIFFERENTIAL MOBILITY ANALYZER AND MASS SPECTROMETER - Various embodiments are described herein for an apparatus that can be used to interface a Differential Mobility Analyzer (DMA) with a Mass Spectrometer (MS). The apparatus includes first and second plates with first and second apertures respectively, and an interface region in between the first and second plates. During use, the first aperture receives mobility separated ions from the DMA, the interface region receives a gas flow to prevent gas outflow from the DMA toward the MS, and the first and second plates are configured to receive voltages to generate an electric field there between to guide the mobility separated ions from the first aperture to the second aperture, which then provides the mobility separated ions to the MS. | 04-23-2009 |
20090108193 | Method And Apparatus For Mass Spectrometric Analysis - A method and an apparatus for examining a sample by means of mass spectrometry. According to the method, the solution comprising the sample to be examined is vaporised in a vaporiser, the vaporised sample solution is sprayed, using a gas flow, into a corona discharge zone, where the examined sample is ionised according to the APCI method, using a corona discharge, to generate gas phase ions, and the ions are separated and directed to a detector. According to the present invention, a vaporiser is used, which is fabricated as a micromechanical structure which comprises the flow channels for the solution and for the carrier gas possibly used for feeding the solution, as well as the heater of the vaporiser, and which are all included in a monolithic structure. The solution is especially suitable for cases in which a very sensitive analysing technique is needed, or in which the available sample quantity is very small (less than 1 μL). | 04-30-2009 |
20090108194 | METHOD AND APPARATUS FOR SELECTIVE FILTERING OF IONS - An adjustable, low mass-to-charge (m/z) filter is disclosed employing electrospray ionization to block ions associated with unwanted low m/z species from entering the mass spectrometer and contributing their space charge to down-stream ion accumulation steps. The low-mass filter is made by using an adjustable potential energy barrier from the conductance limiting terminal electrode of an electrodynamic ion funnel, which prohibits species with higher ion mobilities from being transmitted. The filter provides a linear voltage adjustment of low-mass filtering from m/z values from about 50 to about 500. Mass filtering above m/z 500 can also be performed; however, higher m/z species are attenuated. The mass filter was evaluated with a liquid chromatography-mass spectrometry analysis of an albumin tryptic digest and resulted in the ability to block low-mass, “background” ions which account for 40-70% of the total ion current from the ESI source during peak elution. | 04-30-2009 |
20090108195 | APPARATUS AND METHOD FOR FORMING A GAS COMPOSITION GRADIENT BETWEEN FAIMS ELECTRODES - A method of separating ions includes providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a gas composition within a first portion of the FAIMS analyzer region to be different from a gas composition within a second portion of the FAIMS analyzer region. The establishment of a gas composition gradient within the FAIMS analyzer region enhances ion focusing and ion transport efficiency. | 04-30-2009 |
20090114808 | Mass spectrometer - A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output. | 05-07-2009 |
20090114809 | ISOTOPE RATIO MASS SPECTROMETER AND METHODS FOR DETERMINING ISOTOPE RATIOS - The present invention relates to a method for determining at least one ratio of different isotopes of at least one element in a sample. The method comprises ionizing the sample to produce ions of the different isotopes of the at least one element, the ions being selected from the group consisting of: multiply charged atomic positive ions, single charged positive ions for hydrogen and single charged positive ions for deuterium, separating the charged positive ions of the different isotopes of the at least one element according to their mass-to-charge ratios, and determining at least one ratio of the different isotopes of said at least one element separated in the previous step. The invention also relates to an apparatus for performing the above method. | 05-07-2009 |
20090114810 | MASS SPECTROMETER - An ion trap mass analyser ( | 05-07-2009 |
20090114811 | ION MOBILITY SPECTROMETER AND METHOD FOR OPERATION - A method for operating an ion mobility spectrometer comprises supplying an analyte substance into a reaction chamber of an ion mobility spectrometer having a closed internal gas circuit and at least one membrane inlet having an inner membrane chamber, changing at least one of flow resistances and gas paths in the closed internal gas circuit, and controlling at least one of a quantity and a concentration of analyte-containing gas flowing from the inner membrane chamber to the reaction chamber. | 05-07-2009 |
20090114812 | ION MOBILITY SPECTROMETER WITH SUBSTANCE COLLECTOR - A method for operating an ion mobility spectrometer that comprises a measuring tube, a substance collector and a membrane inlet, the measuring tube, the substance collector and the membrane inlet defining a closed internal gas circuit, comprising separating the closed internal gas circuit from an external sample gas flow through the membrane inlet, transferring circulating gas containing an analyte substance from the membrane inlet to the substance collector, the analyte substance accumulated in the substance collector, releasing the accumulated analyte substances, and transferring the released analyte substances to the measuring tube. | 05-07-2009 |
20090121123 | Mass Spectrometer - An ion guide or ion trap ( | 05-14-2009 |
20090121124 | Increasing Ionization Efficiency in Mass Spectroscopy - A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided. | 05-14-2009 |
20090121125 | Blind Extraction of Pure Component Mass Spectra from Overlapping Mass Spectrometric Peaks - A method of obtaining pure component mass spectra or pure peak elution profiles from mass spectra of a mixture of components involves estimating number of components in the mixture, filtering noise, and extracting individual component mass spectra or pure peak elution profiles using blind entropy minimization with direct optimization (e.g. downhill simplex minimization). The method may be applied to deconvolution of pure GC/MS spectra of overlapping or partially overlapping isotopologues or other compounds, separation of overlapping or partially overlapping compounds in proteomics or metabolomics mass spectrometry applications, peptide sequencing using high voltage fragmentation followed by deconvolution of the obtained mixture mass spectra, deconvolution of MALDI mass spectra in the separation of multiple components present in a single solution, and specific compound monitoring in security and/or environmentally sensitive areas. | 05-14-2009 |
20090121126 | HIGH RESOLUTION EXCITATION/ISOLATION OF IONS IN A LOW PRESSURE LINEAR ION TRAP - Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor. | 05-14-2009 |
20090121127 | SYSTEM AND METHOD FOR SPATIALLY-RESOLVED CHEMICAL ANALYSIS USING MICROPLASMA DESORPTION AND IONIZATION OF A SAMPLE - A method and system for desorbing and ionizing molecules from a sample for mass spectrometry using a microplasma device is disclosed. The system and method relies upon a microplasma device, or array of such devices, to partially ionize a gas to form a microplasma. The ionized gas can be a mixture of a noble gas, such as neon or argon, and hydrogen (H | 05-14-2009 |
20090121128 | Chemical Detection System and Method Using a Prediction Methodology - The exemplary embodiments provide a method, system, and device for identifying chemical species in a sample. According to one embodiment, the method, system, and device may include introducing a sample gas into a differential ion mobility device, ionizing at least a portion of the sample gas to generate at least one ion species, filtering the at least one ion species between a pair of filter electrodes, generating a detection signal in response to the at least one ion species depositing a charge on a collector electrode, and detecting a spectral peak associated with the at least one ion species. | 05-14-2009 |
20090127453 | METHOD FOR INTRODUCING IONS INTO AN ION TRAP AND AN ION STORAGE APPARATUS - A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture. | 05-21-2009 |
20090127454 | BIOMARKERS USEFUL FOR DIAGNOSING PROSTATE CANCER, AND METHODS THEREOF - The present invention describes a method for predicting a health-state indicative of the presence of prostate cancer. The method measures the intensities of specific small biochemicals, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to the intensities observed in a population of healthy individuals and/or to the intensities previously observed in a population of confirmed prostate cancer-positive individuals. The method enables a practitioner to determine the probability that a screened patient is positive for prostate cancer. | 05-21-2009 |
20090134321 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a mass selective ion trap ( | 05-28-2009 |
20090134322 | APPARATUS AND METHOD FOR OPERATING A DIFFERENTIAL MOBILITY ANALYZER WITH A MASS SPECTROMETER - An apparatus and method of analyzing ions is described in which a Differential Mobility Analyzer (DMA) is combined with an analysis device. The DMS can be operated in first and second modes of operation to produce a plurality of ions that are sampled and analyzed by the analysis device. In the first mode of operation the DMA is configured to enable ion mobility separation and the analysis device samples and analyzes ions having ion mobility in a certain range of ion mobility and in the second mode of operation the DMA is configured to disable ion mobility separation and the analysis device samples and analyzes ions without discrimination based on ion mobility. | 05-28-2009 |
20090134323 | MULTIDIMENSIONAL MASS SPECTROMETRY OF SERUM AND CELLULAR LIPIDS DIRECTLY FROM BIOLOGIC EXTRACTS - A method for determination of at least one of the lipid species in a biological sample comprising subjecting the sample to lipid extraction to obtain a lipid extract and subjecting the resulting lipid extract to multidimensional electrospray ionization mass spectrometry using either precursor ion or neutral loss scanning (or both) of all naturally occurring aliphatic chains, lipid fragments and precursor ions leading to observed fragments to generate a multidimensional matrix whose contour densities provides structural and quantitative information directly without chromatography. A method for determination of lipid content and/or lipid molecular species composition and quantity directly from lipid extracts of a biological sample comprising subjecting said lipid extract to electrospray ionization multidimensional mass spectrometry by comparisons to standards and algorithms described herein. | 05-28-2009 |
20090134324 | Partitions for Forming Separate Vacuum-Chambers - A mass spectrometry system comprises a panel movable between an open and closed position relative to a housing. At least part of ion-optics is mounted to the panel. The housing surrounds ion-optics and a partition forms a gas barrier separating vacuum-chambers within the housing when the panel is in the closed position. The gas barrier formed by the partition is broken when the panel moves to the open position. | 05-28-2009 |
20090140136 | Method Of Analyzing Protein - The primary structure or the modification state of a protein is analyzed in detail. First, an analyte protein is subjected to PMF analysis (S | 06-04-2009 |
20090140137 | IONIZATION METHOD AND APPARATUS USING ELECTROSPRAY - A biological sample can be subjected to measurement, description and ionization of ions is possible under atmospheric pressure without undergoing pretreatment. Imaging having a resolution on the nanometer order can be performed. An STM needle (probe) of an XYZ-axis-drive piezoelectric element is oscillated along the Z axis to contact the sample to a depth on the nanometer order and capture molecules at the needle tip. A pulsed high voltage is applied to the needle, achieving needle electrospray. The sample molecules are then desorbed and ionized, and mass spectrometry is carried out. The needle is swept in the XY directions, oscillation is repeated and an image obtained by molecular imaging of a nanometer area of the biological sample is measured. The probe may be brought into contact with a droplet produced at the tip of a capillary connected to the outlet port of a liquid chromatograph to capture a sample. | 06-04-2009 |
20090140138 | Linear FAIMS Power Supply - In various embodiments the present teachings provide high-voltage, asymmetric-waveform power supplies useful for, e.g., differential mobility spectrometry. In various embodiments, provided are high-voltage, asymmetric-waveform power supplies for high-field asymmetric waveform ion mass spectrometers having field values greater than about 5,000 volts cm | 06-04-2009 |
20090140139 | SYSTEMS AND METHODS FOR ANALYZING SUBSTANCES USING A MASS SPECTROMETER - Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selecting the emitted ions for a designated ion; fragmenting the designated ions; scanning for a plurality of designated ion fragments; determining a designated fragment chromatographic trace for each designated ion fragment; and generating a combined chromatographic trace corresponding to a non-linear combination of a plurality of designated fragment chromatographic traces. | 06-04-2009 |
20090152457 | Method for Analysis of a Solid Sample - Described is a method for analysis of a solid sample and, in particular, for analysis of the material composition and distribution in or on a solid surface. The surface to be analysed is covered with caesium, at least partially and/or in regions, and the surface is irradiated with an analysis beam which contains predominantly or exclusively polyatomic ions with at least 3 atoms per ion. The secondary ions which are produced are then analysed on caesium compound. | 06-18-2009 |
20090152458 | METHOD AND APPARATUS FOR ION FRAGMENTATION IN MASS SPECTROMETRY - A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase radical species separately from the analyte ions, and mixes the gas-phase analyte ions and the radical species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase radical species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the radical species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions. | 06-18-2009 |
20090159790 | METHOD AND SYSTEM FOR DESORBING AND IONIZING CHEMICAL COMPOUNDS FROM SURFACES - The invention relates to a method and system for ionizing analyte-containing sample lying on a surface of a substrate. The method comprises directing to the sample a heated flow of desorption gas in order to desorb analyte from the surface, and simultaneously directing to the sample light capable of ionizing the desorbed analyte in the presence of the desorption gas. The invention provides a method and system suitable for efficiently producing ions of neutral and nonpolar molecules on surfaces, for example for mass spectrometric purposes. | 06-25-2009 |
20090159791 | Charge control for ionic charge accumulation devices - A method for controlling charge flux into a charge accumulation device includes determining a charge accumulation time during which charges are to be accumulated in the charge accumulation device, measuring a charge flux of a first ion beam produced from an ion source, determining a target number of charges to be accumulated in the charge accumulation device during the charge accumulation time based on the measured charge flux and, based on the determined target number of charges, modulating a second ion beam produced from the ion source to cause the target number of charges from the second ion beam to be accumulated in the charge accumulation device during the charge accumulation time. An ion processing device is configured for controlling the charge flux. An ion beam modulator modulates the ion beam. | 06-25-2009 |
20090159792 | Oral Detection Test for Cannabinoid Use - A method for confirming the active intake of marijuana and its active component Δ | 06-25-2009 |
20090159793 | IDENTIFICATION OF BIOMARKERS IN BIOLOGICAL SAMPLES AND METHODS OF USING SAME - The present invention is directed to methods of identifying biomarkers in liquid biological samples obtained from cancer patients or patients exhibiting a disease state. Such methods may include the use of electrospray ionization-time of flight mass spectrometry (ESI-TOF MS). | 06-25-2009 |
20090166523 | USE OF CARBON NANOTUBES (CNTS) FOR ANALYSIS OF SAMPLES - The present invention relates to the use of carbon nanotubes as a substrate for chemical or biological analysis. The invention further relates to the use of this material in separation adherence and detection of chemical of biological samples. Carbon nanotubes are envisaged as surface material of a fixed substrate or in suspension and applications include but are not limited to processes which involve desorption-ionization of a sample, more specifically mass spectroscopy. | 07-02-2009 |
20090166525 | Mass Spectrometer - A method of chemical separation includes dispensing a sample from a sample pumping system, pumping a solvent from a solvent gradient pumping system to elute the dispensed sample through a separation column, identifying an analyte of interest in the eluting sample, and pumping a solvent from the sample pumping system for peak parking of the analyte in the separation column. | 07-02-2009 |
20090166526 | Method of and Equipment for Measuring Ionic Mobility - Method of and a device for measuring ion mobility, wherein ions in a medium are carried by means of an electric field and their mobility is measured. The measurement is facilitated by keeping the medium in a shear flow of the Couette type by rotating the essentially parallel electrodes with respect to each other. | 07-02-2009 |
20090166527 | MASS SPECTROMETER ARRANGEMENT WITH FRAGMENTATION CELL AND ION SELECTION DEVICE - A method of mass spectrometry having the steps of, in a first cycle: storing sample ions in a first ion storage device; ejecting the stored ions out of the first ion storage device into a separate ion selection device; selecting a subset of the ions in the ion selection device; ejecting the subset of ions selected within the ion selection device to a fragmentation device; directing ions from the fragmentation device back to the first ion storage device without passing them through the said ion selection device; receiving at least some of the ions ejected from the first ion storage device, or their derivatives, back into the first ion storage device; and storing the received ions in the first ion storage device. | 07-02-2009 |
20090166528 | METHOD OF ION ABUNDANCE AUGMENTATION IN A MASS SPECTROMETER - A method of improving the detection limits of a mass spectrometer by: generating sample ions from an ion source; storing the sample ions in a first ion storage device; ejecting the stored ions into an ion selection device; selecting and ejecting ions of a chosen mass to charge ratio out of the ion selection device; storing the ions ejected from the ion selection device in a second ion storage device without passing them back through the ion selection device; repeating the preceding steps so as to augment the ions of the said chosen mass to charge ratio stored in the second ion storage device; and transferring the augmented ions of the said chosen mass to charge ratio back to the first ion storage device for subsequent analysis. | 07-02-2009 |
20090166529 | METHOD FOR PREPARING SPECIMEN FOR MASS SPECTROMETRY - The present invention provides a specimen preparation method for mass spectrometry based on Matrix Assisted Laser Desorption Ionization (MALDI), wherein the method enables to form microcrystals (cocrystals) between matrices and biological molecules (protein and the like) on a biological tissue to generate ions thereof highly efficiently and to perform highly sensitive measurement. Microcrystals are formed on the specimen containing biological molecules, i.e. objects of the measurement, by spraying matrix solution beforehand. Furthermore, dispensation of matrix solution on the microcrystals allows crystals to grow by making preformed micro-matrix crystals as crystal nuclei. Therefore, much finer and more homogeneous crystals (cocrystals) are prepared to enable to perform highly sensitive mass spectrometry based on MALDI. The present invention is a specimen preparation method for mass spectrometry based on matrix assisted laser desorption ionization, wherein the method comprises steps forming microcrystals of matrices on the specimen by spraying matrix solution on the specimen and allowing the microcrystals to grow further by dispensing matrix solutions to the specimen. | 07-02-2009 |
20090166530 | ION MOBILITY SPECTROMETER AND METHOD THEREOF - An ion mobility spectrometer and method thereof are disclosed. The ion mobility spectrometer comprises an electrode and an ion source arranged adjacent to the electrode, wherein the ion mobility spectrometer further comprises: a single or a group of focusing guide electrodes arranged on the side of the ion source far away from the electrode and shaped as a funnel to output ions from the ion source; and a storage section arranged on the ion-outputting side of the focusing guide electrode for storing ions generated from the ion source. With the scheme of separating the ion source and the storage region, the present invention can facilitate exchange of different ion sources, so that a source can be replaced with another different source without any change in the subsequent configuration. The storage section can be made very thin in the direction of ion movement, its diameter can be very large, and the internal electric field is almost zero. Thus, it is possible to collect a huge amount of ions with a very small cluster thickness and a directional velocity of almost zero, leading to reduction in spread of ion mobility spectrum and increase in resolution. | 07-02-2009 |
20090173876 | Method of detecting and/or measuring hepcidin in a sample - Methods of isolating and/or analyzing hepcidin by mass spectrometry and methods of quantifying hepcidin are disclosed. | 07-09-2009 |
20090173877 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first ion trap or ion guide ( | 07-09-2009 |
20090173878 | Methods for Processing Tandem Mass Spectral Data for Protein Sequence Analysis - Various mass spectroscopy-based methods are provided to improve protein sequencing by detecting z-type product ions generated from the protein. A polypeptide is introduced to a mass spectrometer, and in particular c- and z-type product ions that are generated by selectively fragmenting the polypeptide. The z-type product ions are distinguished from the c-type product ions and the mass-to-charge ratio of at least a portion of the z-type product ions are determined. From the mass of the z-type product ions, a putative chemical composition is identified for at least a portion of the z-type product ions, c-type product ions, or both, which is used to determine polypeptide compositions. Further provided are various methods for reducing spectral noise, instrument calibration and database searching and verification. | 07-09-2009 |
20090173879 | GAS ANALYZING METHOD AND GAS ANALYZING APPARATUS - Ions obtained through EI process from a first gas are subjected to mass analysis to obtain ion intensities which are stored in a first file, and ions obtained through soft ionization process from a second gas having same concentration of components as that of the first gas are subjected to mass analysis to obtain ion intensities which stored in a second file, and molecular weights are determined based on parent ions from soft ionization measurement data. A mass spectrum corresponding to the determined molecular weight is read out based on an NIST database, and the ion intensity data stored in the first file and the read out NIST data are compared with each other, and component molecules of the first gas are determined based on the comparison results. Qualitative analysis of mixed gas can be conducted in real time with high accuracy by making effective use of the measurement data of both mass analysis based on EI process and mass analysis based on soft ionization process. | 07-09-2009 |
20090179146 | FLUIDICS DEVICE - The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample. | 07-16-2009 |
20090179147 | SYSTEMS, METHODS, AND COMPUTER-READABLE MEDIUM FOR DETERMINING COMPOSITION OF CHEMICAL CONSTITUENTS IN A COMPLEX MIXTURE - Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information. The library of information includes data generated by the separation tool and mass spectrometer, and also includes separation and mass spectrometry data for both identified and unidentified chemical entities. An indication of the chemical constituent of the sample is made available in human-accessible form. | 07-16-2009 |
20090179148 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - Performing an MS3 with a tandem mass spectrometer causes problems of increase in size of the device and of increase in cost. Likewise, a plural number of times MS/MS analyses are even more difficult. An electrode to create a harmonic potential is disposed in a collision cell, and fragment ions produced by the first-time collision induced dissociation are accumulated in the harmonic potential. Target ions of the subsequent stage are let out, by means of an axial resonance excitation, selectively from the accumulated ions. The ions are excited in the axial direction to have a potential exceeding the harmonic potential. Thereby, the second-time collision induced dissociation is performed by means of a potential difference provided at the subsequent stage. In addition, an operation to return the ions back to the harmonic potential enables a plural number of times MS/MS analyses to be performed. | 07-16-2009 |
20090179149 | MASS SPECTROMETER AND MASS SPECTROMETRIC ANALYSIS METHOD - An MS/MS spectrometric analysis method obtains throughput and mass resolving power of precursor ions. In a mass spectrometer, ions, which are introduced and accumulated in an ion trap unit, are resonance-extracted mass-selectively. A profile of precursor ions at the m/z axis of the ion trap and a profile at the mass analyzer portion, which performs mass analysis of the ions extracted from a collision induced dissociation portion, is obtained by performing a measurement when the injection energy to the collision induced dissociation portion is low, and when the injection energy to the collision induced dissociation portion is high. The profile at the m/z axis of the ion trap of the obtained two-dimensional spectrum is substituted with the profile at the m/z axis of the mass analyzer portion. In this way, the m/z of both the precursor ions and the fragment ions can be determined with high mass resolving power. | 07-16-2009 |
20090189064 | ULTRA COMPACT ION MOBILITY BASED ANALYZER APPARATUS, METHOD, AND SYSTEM - An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and, thereby, reduce analyzer size, cost, and power requirements. | 07-30-2009 |
20090189065 | Method of mass spectrometry and mass spectrometer - In a mass spectrometer introducing ions produced at an ion source, and including quadrupole rods which have an inlet and an outlet and to which a radio-frequency voltage is applied, the mass spectrometer, i.e., a mass spectrometry device implemented by a linear trap which exhibits high ejection efficiency, high mass resolution, and low ejection energy, executes the following steps: Trapping at least part of the ions by a trap potential generated on the central axis of a quadrupole field, oscillating part of the trapped ions in an intermediate direction between the mutually-adjacent quadrupole rods, ejecting the oscillated ions by an extraction field, and detecting the ejected ions or introducing the ejected ions into another detection process. | 07-30-2009 |
20090189066 | ION IMPLANTATION DEVICE CONTROL METHOD, CONTROL SYSTEM THEREOF, CONTROL PROGRAM THEREOF, AND ION IMPLANTATION DEVICE - A control method of an ion implantation device that radiates an ion beam emitted from an ion source via an optical element onto a material to be treated, includes the steps of: measuring the spatial distribution of the ion beam in the vicinity of the material to be treated; estimating the emittance, which is the spatial and angular distribution of the ion beam of the ion source, from the measured spatial distribution, by using an ion beam trajectory calculation method; calculating the operating conditions of the optical element so that the ion beam in the vicinity of the material to be treated has a desired spatial distribution, by using the estimated emittance and the trajectory calculation method; and operating the ion implantation device by using the calculated operating conditions of the optical element. | 07-30-2009 |
20090189067 | COMPONENTS FOR REDUCING BACKGROUND NOISE IN A MASS SPECTROMETER - Novel components reduce background noise caused by secondary ions generated by metastable entity bombardment in a mass spectrometric system. Layered structures for exit electrodes and deflector plates confine secondary ions in a local low-energy well, preventing them from entering the detector. | 07-30-2009 |
20090189068 | DETECTION OF SILICA SPECIES IN HOT PHOSPHORIC ACID - In one embodiment, a method of analyzing silica species in a phosphoric acid solution includes the acts of: processing a sample of the phosphoric acid solution through an anion exchange resin to provide a processed sample; and analyzing the processed sample to determine a concentration of at least one silica species in the phosphoric acid solution. | 07-30-2009 |
20090189069 | System and method for performing charge-monitoring mass spectrometry - A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 10 | 07-30-2009 |
20090189070 | ION MOBILITY SPECTROMETER INSTRUMENT AND METHOD OF OPERATING SAME - An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that applies switched electric fields at a specified switching rate to the drift tube segments to thereby produce at the ion outlet only ions having a predefined ion mobility or range of ion mobilities. | 07-30-2009 |
20090189071 | ION FRAGMENTATION IN MASS SPECTROMETRY - In a tandem mass spectrometer using a collision cell for ion fragmentation, the upper limit of the collision energy required for collision induced dissociation (CID) can be extended without reaching or going beyond the upper electrical discharge limit of the system components. The present teachings describe a method of lifting the potential energy of ions to a predetermined level sufficient for CID fragmentation while satisfying a discharge free condition. The present teaching also describes a method of lifting the potential energy of the fragment ions after CID fragmentation so that the product ions have sufficient energy for mass analysis. | 07-30-2009 |
20090194678 | METHODS AND DEVICES FOR THE MASS-SELECTIVE TRANSPORT OF IONS - A method for the mass-selective transport of ions, especially in a mass spectrometer, comprises the steps movement of the ions on a movement path on which a plurality of electrodes are arranged, and loading the electrodes with pulse-shaped acceleration voltages under the effect of which the ions experience a mass-dependent change of speed, wherein the electrodes are loaded with the pulse-shaped acceleration voltages such t at target ions with a pre-determined target mass are accelerated along the movement path. Furthermore, an ion conductor for mass-selective transport of ions, especially in a mass spectrometer, is described. | 08-06-2009 |
20090194679 | METHODS AND APPARATUS FOR REDUCING NOISE IN MASS SPECTROMETRY - The invention pertains to methods and apparatus for performing mass spectrometry with reduced noise. In some embodiments, an additional amount of a carrier gas is introduced into a mass spectrometer to reduce the noise. | 08-06-2009 |
20090194680 | Method and Apparatus for Normalizing Performance of an Electron Source - A method for operating a mass spectrometer includes determining a first performance characteristic while operating the mass spectrometer with a first electron emitter, storing first information relating to the first performance characteristic, determining a second performance characteristic while operating the mass spectrometer with a second electron emitter, storing second information relating to the second performance characteristic, and thereafter switching from operation using the first electron emitter to operation using the second electron emitter. The switching includes using the first and second information to normalize performance of the second electron emitter after the switching relative to performance of the first electron emitter before the switching. | 08-06-2009 |
20090194681 | Method and Apparatus for Response and Tune Locking of a Mass Spectrometer - A mass spectrometer and a technique for operating it involve setting an operating parameter that influences a rate of flow of electrons from an electron source into an ion volume so that ions produced from a material in the ion volume in response to electrons satisfy an ion production target, performing a plurality of analytical runs using the mass spectrometer with the electron source while monitoring an operational characteristic, and adjusting the operating parameter in response to the monitoring to compensate for a change over time in the operational characteristic in a manner so that the ion production target remains satisfied. | 08-06-2009 |
20090194682 | PEPTIDE IDENTIFICATION AND QUANTITATION BY MERGING MS/MS SPECTRA - The present invention is directed to methods of merging spectral data resulting from collision fragmentation processes, such as, for example, Pulsed Q Dissociation (PQD), high-energy collision-induced dissociation (HCD), electron transfer disassociation (ETD), collision-induced dissociation (CID), and photo-dissociation processes, such as, but not limited to, infrared multi-photon photo-dissociation (IRMPD), to provide the desired qualitative and quantitative information on a single peptide. By merging such ETD, CID, or IRMPD scans with corresponding HCD scans that are obtained on the same precursor, the quality of the resulting spectrum is increased so as to provide more confident identification of peptides and correspondingly the quantification is enhanced because the HCD method of the MS/MS spectrum produces higher abundances of detectable reporter ions. Such methods, as disclosed herein, are especially applicable for peptides which experience predominant neutral loss in the ion trap, e.g., phosphorylated. | 08-06-2009 |
20090194683 | METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION - In accordance with an aspect of an embodiment of the present invention, there is provided a method for fragmenting ions in an ion trap of a mass spectrometer. The method comprises a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; and, e) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. | 08-06-2009 |
20090194684 | METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION WITH PULSED PRESSURE - Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10-4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non-steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6×10-5 Torr to about 5×10-4 Torr for a first elevated-pressure duration; and f within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time. | 08-06-2009 |
20090194685 | HIGH-THROUGHPUT SCREENING OF METABOLIC DISORDERS USING A LASER DESORPTION ION SOURCE COUPLED TO A MASS ANALYZER - Methods and kits for high throughput screening and analysis of metabolic disorders using a laser desorption ion source coupled to a mass analyzer (for example, MALDI) are provided. The metabolic disorders can be amino acid, organic acid or fatty acid oxidation disorders. A panel of disorders can be analyzed at high speeds. The methods and kits are particularly useful for newborn screening (NBS) of metabolic disorders. | 08-06-2009 |
20090200458 | Adhering Matter Inspection Equipment and Method for Inspecting Adhering Matter - A technology for collecting a granular substance adhering to a baggage with high rate without touching the substance and inspecting whether a dangerous or specific sample material is adhered to the baggage. A method for simplifying or automating such an inspection is also provided. An adhering matter inspection equipment ( | 08-13-2009 |
20090200459 | ANALYTIC SPECTROMETERS WITH NON-RADIOACTIVE ELECTRON SOURCES - In an analytical spectrometer in which accelerated electrons are used to ionize analytes, a non-radioactive electron source uses a gas discharge to generate the electrons. The gas discharge is located in a substantially hermetic source chamber and the free electrons in the plasma of the gas discharge are accelerated in an electric acceleration region towards a partition wall which separates the source chamber from a reaction chamber. The partition wall is permeable to the accelerated electrons but impermeable to gas in the source chamber so that the electrons penetrate the partition wall into the reaction chamber and generate primary ions that chemically ionize the analytes. | 08-13-2009 |
20090200460 | ETHANE IMPLANTATION WITH A DILUTION GAS - To implant a carbon-containing species, a gas containing carbon is ionized in the ion chamber. The ionization of this gas will typically produce a number of ionized species. However, many of these resulting ionized species are not beneficial to the desired implant, as they contain only non-carbon atoms. These species must be eliminated before the implantation, leaving only carbon-based species. However, the current of the desired species may be low, thereby requiring extra energy or time to implant the desired dosage of carbon into a substrate. This can be improved through the use of a second gas. This second gas is used to dilute the primary carbon-containing gas to be ionized in the ion chamber. By incorporating this dilution gas, more of the resulting ionized species are beneficial to the carbon implantation. | 08-13-2009 |
20090206245 | Mass analysis method using fine metal particles - It is an object of the present invention to provide a novel mass spectrometry method which overcomes the conventional problems mentioned above, which can analyze at a high sensitivity and high accuracy a chemical reaction on a surface of a self-organized membrane bound to a metal, and which can be applied to analysis of structures of a sugar chain in future. According to the present invention, a method for performing mass spectrometry of sulfur atom-containing derivatives of an organic residue, characterized in that the method includes ionizing a metal-organic residue complex into the derivatives, wherein the complex has the organic residue bound through a sulfur atom to the metal is provided, thereby solving the above problems. | 08-20-2009 |
20090206246 | Detection Apparatus and Methods - Detection apparatus including an IMS detector ( | 08-20-2009 |
20090206247 | ADJUSTING THE DETECTOR AMPLIFICATION IN MASS SPECTROMETERS - The amplification of secondary-electron multipliers in mass spectrometers is automatically adjusted by generating mass spectra with single ion signals, determining the average value of the peak heights of these single ion signals, and setting the amplification so that the average peak height assumes a desired nominal value. The amplification may be set via the supply voltage of the secondary-electron multiplier and can be increased or decreased by a desired factor using the known characteristic of the secondary-electron multiplier. | 08-20-2009 |
20090212205 | METHOD OF IMPROVING SIGNAL-TO-NOISE FOR QUANTITATION BY MASS SPECTROMETRY - Selectivity of a measurement from a mass spectrometer is improved by selecting an extracted ion current window for the measurement after data acquisition. A plurality of mass spectra are acquired over a period of time. A first extracted ion current window is selected and from the plurality of mass spectra a first intensity as a function of time is calculated for an ion using the first extracted ion current window. A second extracted ion current window is selected and from the plurality of mass spectra a second intensity as a function of time is calculated for the ion using the second extracted ion current window. A first signal-to-noise ratio of the first intensity is compared with a second signal-to-noise ratio of the second intensity. If the second signal-to-noise ratio is greater than the first signal-to-noise ratio, the second intensity as a function of time is used for the measurement. | 08-27-2009 |
20090212206 | MASS SPECTROMETRIC METHOD AND MASS SPECTROMETER FOR ANALYZING A VAPORIZED SAMPLE - A mass spectrometric method for analyzing a vaporized sample, comprising the steps of: forcing sequentially generated charge-laden liquid drops to move towards a receiving unit of a mass spectrometer along a traveling path; establishing a concentration gradient for a target analyte so as to permit diffusion of the vaporized sample which contains at least one of the target analyte therein along a plurality of diffusing paths; and introducing the target-analyte containing vaporized sample through an inlet such that at least one of said diffusing paths intersects said traveling path so as to enable said at least one target analyte to be occluded in at least one of said charge-laden liquid drops to thereby form at least one corresponding ionized analyte for analysis by the mass spectrometer. | 08-27-2009 |
20090212207 | Chemical Detection System and Method Using a Capacitive Trans Impedance Amplifier - The exemplary embodiments provide a method, system, and device for identifying chemical species in a sample. According to one embodiment, the method, system, and device may include introducing a sample gas into a differential ion mobility device, ionizing at least a portion of the sample gas to generate at least one ion species, filtering the at least one ion species between a pair of filter electrodes, generating a detection signal in response to the at least one ion species depositing a charge on a collector electrode, and detecting a spectral peak associated with the at least one ion species. | 08-27-2009 |
20090212208 | Method and Apparatus for Time-of-Flight Mass Spectrometry - A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory. | 08-27-2009 |
20090218482 | METHOD AND DEVICE FOR THE MASS SPECTROMETRIC DETECTION OF COMPOUNDS - A method for mass-spectrometric detection of compounds in a gas flow includes: alternatingly forming first and a second beams by switching between electron pulses/pulse trains and photon pulses/pulse trains, the photon pulses/pulse trains being generated by an excimer lamp, and the switching between the electron pulses/pulse trains and the photon pulses/pulse trains occurring at a switching frequency above 50 Hz; disposing the gas flow in an ionization region crossed by the first and second beams so as to ionize volume units in the gas flow so as to form ions of the compounds; deflecting the ions in an effective region of an electric field to a mass-spectrometric device; and sensing the ions with a mass-spectrometric process of the mass-spectrometric device. | 09-03-2009 |
20090218483 | Analyzing Method and Analyzing Apparatus - An analysis apparatus includes a first process part for removing a film formed on a substrate by irradiating the film with ultraviolet light, a second process part for providing a solution onto a surface of the substrate for dissolving an object being analyzed on the substrate, and a third process part for analyzing the object being analyzed in the solution that is used in the second step. | 09-03-2009 |
20090218484 | CONCENTRATING MASS SPECTROMETER ION GUIDE, SPECTROMETER AND METHOD - An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the i | 09-03-2009 |
20090224148 | APPARATUS AND METHOD FOR PERFORMING MASS SPECTROSCOPY - Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily reveals data pair information for compounds present with smaller signals. | 09-10-2009 |
20090230299 | ION SOURCE, ION BEAM PROCESSING/OBSERVATION APPARATUS, CHARGED PARTICLE BEAM APPARATUS, AND METHOD FOR OBSERVING CROSS SECTION OF SAMPLE - An ion beam machining and observation method relevant to a technique of cross sectional observation of an electronic component, through which a sample is machined by using an ion beam and a charged particle beam processor capable of reducing the time it takes to fill up a processed hole with a high degree of flatness at the filled area. The observation device is capable of switching the kind of gas ion beam used for machining a sample with the kind of a gas ion beam used for observing the sample. To implement the switch between the kind of a gas ion beam used for sample machining and the kind of a gas ion beam used for sample observation, at least two gas introduction systems are used, each system having a gas cylinder a gas tube, a gas volume control valve, and a stop valve. | 09-17-2009 |
20090230300 | RAPID DETECTION OF VOLATILE ORGANIC COMPOUNDS FOR IDENTIFICATION OF BACTERIA IN A SAMPLE - In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence of the bacteria. | 09-17-2009 |
20090230301 | MASS SPECTROMETRY APPARATUS AND METHOD - Disclosed is a mass spectrometry apparatus and method capable of providing enhanced analysis sensitivity in a mass spectrometric analysis for a small amount of ions. A quadrupole rod-type ion guide is employed to temporarily accumulate ions to be introduced into an ion trap, and ions are introduced into the ion guide in an amount less than a saturated ion amount in the ion guide, and accumulated in an exit end of the ion guide. As compared with an octopole rod-type ion guide, the quadrupole rod-type ion guide has a higher ion-converging capability, and therefore can confine and hold a small amount of ions around an ion optical axis, although it is inferior in ion-accumulating capability. This makes it possible to efficiently introduce the ions into the ion trap through two openings of an electric field-correcting electrode and an entrance endcap electrode, so as to perform a high-sensitive analysis. | 09-17-2009 |
20090230302 | Electron Transfer Dissociation for Biopolymer Sequence Analysis - The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and proteins by mass spectrometry. In the case of peptides, the invention promotes fragmentation along the peptide backbone and makes it possible to deduce the amino acid sequence of the sample, including modified amino acid residues, through the use of an RF field device. | 09-17-2009 |
20090236513 | SYSTEMS AND METHODS FOR ANALYZING SUBSTANCES USING A MASS SPECTROMETER - Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment. | 09-24-2009 |
20090236514 | MEASUREMENT OF ION MOBILITY SPECTRA - The invention relates to measuring the mobility spectra of ions with ion mobility spectrometers (IMS). The invention provides an analog modulation of the ion current of an IMS ion source with a continuous modulation function, the instantaneous frequency of which temporally varies across a large frequency range, and a generation of the mobility spectrum from the measured ion current by a correlation analysis with the modulation pattern. The modulation can, for example, be produced by the gating grid, which is usually present. The analog modulation removes many of the difficulties which occur with square-wave modulation and leads to a surprisingly stable evaluation which is relatively insensitive to noisy signals and produces a high mobility resolution at very low noise. | 09-24-2009 |
20090236515 | Method for the Characterization of the Three-Dimensional Structure of Proteins Employing Mass Spectrometric Analysis and Computational Feedback Modeling - A method for characterizing the three-dimensional surface structure of molecules, particularly proteins and protein complexes, employing mass spectrometric analysis, an electrospray ionization (ES) source, a novel data interpretation process that utilizes comparisons of particular binding constants (K | 09-24-2009 |
20090242748 | Monopole Time-of-Flight Tandem Mass Spectrometer - A tandem mass spectrometer operable to determine properties of chemical and biochemical compounds (analytes) comprises an ion source, a monopole ion processing cell positioned to receive primary ions from the ion source and a mass analyzer positioned to receive secondary ions output from the monopole ion processing cell. The monopole ion processing cell comprises an elongate inner electrode and an elongate outer electrode radially offset from and partially surrounding the inner electrode. In one embodiment, the elongate inner and outer electrodes of monopole ion processing cell are segmented, and at least one of the outer electrode segments defines an axial slot through which the secondary ions are radially output to the mass analyzer. | 10-01-2009 |
20090242749 | MASS SPECTROMETER - An Electrospray ionisation ion source is disclosed comprising a capillary tube ( | 10-01-2009 |
20090242750 | PROTEIN PURIFICATION AND IDENTIFICATION - The present invention relates to a method for protein purification and identification. More closely the invention relates to a method for protein pre-fractionation and identification resulting in improved yield of identified proteins. The method for pre-fractionation of protein samples, includes the following steps: a) reducing disulphide bridges (S-S bridges) or protecting cysteines in the proteins in the sample; b) loading the sample onto an ion exchange column; c) eluting the sample; d) collecting each fraction from the column separately in air sealed containers devoid of chromatographic media; e) desalting each fraction on a single RPC (reversed phase chromatography) trap column; f) separating each fraction in a second dimension RPC step to obtain further separated proteins which are collected in fractions; and g) identifying the further separated proteins by MS. | 10-01-2009 |
20090242751 | Power Supply Regulation Using A Feedback Circuit Comprising An AC And DC Component - In various aspects, ion sources, mass spectrometer systems, and a power supply circuit coupled to a feedback circuit are provided. A power supply is provided that includes at least the power supply circuit and is operable to transfer charge to a load. The feedback circuit is responsive to a DC component of an output voltage supplied by the power supply in a first feedback loop and an AC component of the output voltage in a second feedback loop to produce a feedback signal representative of at least one of: a value of the output voltage before a charge transfer from a capacitor of the power supply to a load; the value of the output voltage during the charge transfer from the capacitor of the power supply to the load; or the value of the output voltage after the charge transfer from the capacitor of the power supply to the load. | 10-01-2009 |
20090242752 | SAMPLE HOLDING DEVICE AND MASS SPECTROSCOPE AND MASS SPECTROSCOPIC METHOD USING THE SAMPLE HOLDING DEVICE - A sample holding device used for a mass spectroscope includes a substrate on which a detection surface is formed, a measuring region formed on the detection surface of the substrate and having placed thereon at least an analyte, and a reference region formed in another region of the detection surface of the substrate except for the measuring region, the reference region having the same configuration as the measuring region except that the former does not have the analyte placed thereon. | 10-01-2009 |
20090250604 | Analysis Method for Biological Sample and Screening Method for Disease Marker - The present invention provides a method for obtaining structural information conveniently and rapidly by generating a negative ion without adding an acidic substance to matrix, thereby improving sensitivity of measurement by a mass spectrometer, and by generating structural specific ions with high reproducibility, and a method for screening disease marker and a method for analyzing a sample containing a biomolecule. A method for mass spectrometry of a sugar chain comprising the steps of: preparing a sample containing a sugar chain; labeling the sugar chain with a labeling compound, to obtain a labeled sugar chain; and subjecting the labeled sugar chain to measurement of negative ions by using a MALDI mass spectrometer, thereby conducting analysis of the sugar chain. A method for screening disease marker comprising the steps of: (1) labeling the biomolecule X derived from a subject affected by a particular disease; subjecting the labeled biomolecule X′ to measurement of negative ions by a MALDI mass spectrometer, (2) separately, labeling the biomolecule Y derived from a subject unaffected by the particular disease; subjecting the labeled biomolecule Y′ to measurement of negative ions by a MALDI mass spectrometer; and (3) comparing mass spectrum of the labeled biomolecule X′ obtained in (1) with mass spectrum of the labeled biomolecule Y′ obtained in (2) to find mass spectrum peaks which are mutually different, thereby ascertaining presence of structure involved in expression of the particular disease. | 10-08-2009 |
20090250605 | METHOD AND SYSTEM OF TANDEM MASS SPECTROMETRY WITHOUT PRIMARY MASS SELECTION FOR MULTICHARGED IONS - The invention proposes a method of tandem mass spectrometry for use in a mass spectrometer having a known characteristic function of the mass-to-charge ratio of the ions to be analysed, characterized in that it comprises the following steps: (a) providing a primary ions source to be analysed, (b) generating a primary mass spectrum of the primary ions, without dissociation, wherein said spectrum contains primary ion peaks of occurrence, (c) from the characteristic function values at the maxima of at least some of said primary mass peaks and from the charge values associated to said peaks, determining correlation laws that all possible multiplets of characteristic function values corresponding to multiplets of charged fragments resulting from the dissociation of parent primary ions of interest corresponding to said primary mass peaks have to meet, (d) concurrently dissociating primary ions of interest associated to primary mass peaks, in order to obtain multiplets of charged fragments from each of said parent primary ions, (e) generating characteristic function values for the dissociated fragments, (f) forming every potential multiplet of said characteristic function values, (g) identifying, from amongst said potential multiplets, the multiplets which meet a proximity criterion in relation to said correlation laws, in order to determine the real multiplets of charged fragments corresponding to the parent primary ions, (h) generating dissociation mass spectra corresponding respectively to the parent primary ions of interest, comprising the peaks associated to the real multiplets of identified fragments. | 10-08-2009 |
20090250606 | AEROSOL MASS SPECTROMETRY SYSTEMS AND METHODS - A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing light. Additional systems and methods are also disclosed. | 10-08-2009 |
20090250607 | METHOD AND APPARATUS TO INCREASE THROUGHPUT OF LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY - An apparatus according to the present invention includes a plurality of sample spraying devices, each of which connects to an LC column. The apparatus includes an electrical circuit that can turn a high voltage between 1 and 5 KV on and off on the time-scale of nanoseconds to milliseconds. The circuit is controlled by a computer program which applies the high voltage to each spray device in a Hadamard sequence. The spray devices are positioned aiming at the mass spectrometer inlet. The preferred configuration of arrangements for the spray devices are in a circle or an arc of a circle around the inlet of a mass spectrometer. | 10-08-2009 |
20090256068 | SOLUTION FRAGMENTATION SYSTEMS AND PROCESSES FOR PROTEOMICS ANALYSIS - A solution-phase digestion process is described. Intact proteins are digested to obtain parent peptides, which are separated and subsequently mass analyzed. Individual parent peptides are digested to obtain daughter peptides, which are also subsequently mass analyzed. Accurate mass data obtained from mass analysis of both parent and daughter peptides are correlated with separations data obtained during separation of the parent peptides to provide peptide identification. The process is expected to provide unique peptides by which to identify intact proteins in a sample without need for MS/MS gas-phase fragmentation. | 10-15-2009 |
20090256069 | APPARATUS FOR DESORPTION AND IONIZATION OF ANALYTES - This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix. | 10-15-2009 |
20090256070 | ION TRAP, MASS SPECTROMETER, AND ION MOBILITY ANALYZER - A compact, low-cost, and simple ion trap capable of operating at a low vacuum level is provided along with technology for utilizing that ion trap to perform mass spectroscopy and analyzing ion mobility without a drop in measurement accuracy. Ions are trapped in a one dimensional potential formed by a potential comprised of a direct current voltage and a potential comprised of an alternating current voltage. The trapped ions are made to collide with an electrode by changing at least the applied direct current voltage or alternating current voltage, and are detected as an electrical current value. | 10-15-2009 |
20090256071 | LASER AND ENVIRONMENTAL MONITORING METHOD - A laser and monitoring system is provided. In another aspect of the present invention, the system includes a laser, pulse shaper and detection device. A further aspect of the present invention employs a femtosecond laser and binary pulse shaping (BPS). Still another aspect of the present invention uses a laser beam pulse, a pulse shaper and a SHG crystal. In yet another aspect of the present invention, a multiphoton intrapulse interference phase scan (hereinafter “MIIPS”) method is used to characterize the spectral phase of femtosecond laser pulses and to correct them. A further aspect of the system of the present invention is employed to monitor environmental chemicals and biological agents, including toxins, explosives, and diseases. | 10-15-2009 |
20090261241 | SINGLE MOLECULE MASS SPECTROSCOPY ENABLED BY NANOELECTROMECHANICAL SYSTEMS (NEMS-MS) - The present invention relates to an apparatus for measuring a mass of a sample, using a nanoelectromechanical system (NEMS) arranged to receive the sample added onto a resonator of the NEMS and a microfluidic sample delivery and sample ionization system. The nanoelectromechanical system is located at an output of the ionization system. The nanoelectromechanical resonator system is highly sensitive and is capable of detecting masses in the single Dalton range. | 10-22-2009 |
20090266980 | MICROCHIP, METHOD FOR USING SUCH MICROCHIP AND MASS SPECTROMETRY SYSTEM - A microchip | 10-29-2009 |
20090266981 | INTERNAL STANDARD MATERIAL, RESIN COMPOSITION, AND MEASUREMENT METHOD - An internal standard material to be added to a specimen containing a material to be measured when measuring the content of the material to be measured by performing mass spectrometry on the specimen includes a hindered phenol compound. | 10-29-2009 |
20090266982 | MASS SPECTROMETRY SUBSTRATE AND MASS SPECTROMETRY METHOD - A mass spectrometry method that makes it possible to perform high-sensitivity detection of a desorbed/ionized object substance to be measured in mass spectrometry in which the object substance to be measured is desorbed and ionized. The method includes placing at least an ionizing agent having two or more functional groups represented by Formula (1) below in a molecule: | 10-29-2009 |
20090272891 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion guide. The ion guide comprises a hollow tubular conductor ( | 11-05-2009 |
20090272892 | Laser Ablation Electrospray Ionization (LAESI) for Atmospheric Pressure, In Vivo, and Imaging Mass Spectrometry - The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI). | 11-05-2009 |
20090272893 | Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry - Disclosed is an apparatus for performing mass spectrometry and a method of analyzing a sample through mass spectrometry. In particular, the disclosure relates to an apparatus capable of ambient mass spectrometry and mass spectral imaging and a method for the same. The apparatus couples laser ablation, flowing atmospheric-pressure afterglow ionization, and a mass spectrometer. | 11-05-2009 |
20090272894 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - A mass spectrometer includes an ionization chamber, a temperature control unit which controls the temperature in the ionization chamber to vaporize a sample in at least one of solid and liquid state in the ionization chamber, an introduction unit which introduces the sample into the ionization chamber, an ion supply unit which supplies ions to the ionization chamber to ionize, in the ionization chamber, the sample vaporized in the ionization chamber, and a mass analyzer which measures the mass of the molecules of the ionized sample. | 11-05-2009 |
20090278037 | ESTIMATION OF ION CYCLOTRON RESONANCE PARAMETERS IN FOURIER TRANSFORM MASS SPECTROMETRY - The present invention comprises a method and system for accurate estimation of the ion cyclotron resonance (ICR) parameters in Fourier-transform mass spectrometry (FTMS/FT-ICR MS). The parameters are essential to estimating the mass to charge ratio of an ion from FT-ICR MS data, the intended purpose of the instrument. Achieving greater accuracy in the parameters assists in greater accuracy of the mass to charge ratio of an ion, and obtaining an accurate estimation of the mass to charge ratio of an ion further aides in detecting mass with sub-ppm accuracy. Estimating mass in this manner enhances identification and characterization of large molecules. The inventive method and system thereby enhances the data obtained by conventional FTMS by accurately estimating ICR parameters. Ultimately, accurate estimates of the masses of molecules and detection and characterization of molecules from FT-ICR MS data are obtained. | 11-12-2009 |
20090278038 | Method and device for generating positively and/or negatively ionized gas analytes for gas analysis - A solution is supposed to be created with a method for generating positively and/or negatively ionized gas analytes for gas analysis in an ion mobility spectrometer or in a mass spectrometer, with which method the gas analyte can be ionized without the restrictions of previous ionization methods for gas analysis in an ion mobility spectrometer or in a mass spectrometer, forming positive and/or negative ions. | 11-12-2009 |
20090278039 | Detection Method for an Ion Migration Spectrum and an Ion Migration Spectrometer Using the Same Method - This invention discloses a detection method for an ion migration spectrum which comprises: acquiring an ion migration spectrum of pure carrier gas and an ion migration spectrum of carrier gas containing a test substance sample; and performing differential process on the ion migration spectrum of said pure carrier gas and the ion migration spectrum of the carrier gas containing the test substance sample to acquire a differential spectrum, wherein the value of a characteristic peak of said differential spectrum represents properties of said sample of substances, said method avoids interferences on the migration spectrum from interference sources of the apparatus itself, thereby improving detection sensitivity and accuracy of the ion migration spectrum; and migration spectrum shift caused by variations in the environmental conditions can be found and corrected through the differential process on the migration spectrum of the pure carrier gas, thereby achieving self-stableness and self-correction of the ion migration spectrometer. This invention further discloses an ion migration spectrum detector and an ion migration spectrometer using said method. | 11-12-2009 |
20090278040 | MULTI-DIMENSIONAL ION MOBILITY SPECTROMETRY METHODS AND APPARATUS - Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity. | 11-12-2009 |
20090283670 | Technique for Monitoring and Controlling A PLasma Process - A time-of-flight ion sensor for monitoring ion species in a plasma includes a housing. A drift tube is positioned in the housing. An extractor electrode is positioned in the housing at a first end of the drift tube so as to attract ions from the plasma. A plurality of electrodes is positioned at a first end of the drift tube proximate to the extractor electrode. The plurality of electrodes is biased so as to selectively attract ions to enter the drift tube and to drift towards a second end of the drift tube. An ion detector is positioned proximate to the second end of the drift tube. The ion detector detects arrival times associated with the at least the portion of the attracted ions. | 11-19-2009 |
20090283671 | Multi-channel electrospray emitter - Provided is a multi-channel electrospray emitter. The emitter includes a plurality of separate or distinct capillaries, each capillary being one channel and terminating in a nozzle, from which the analyte is sprayed. The multi-channel nanoelectrospray emitter may comprise a microstructured fibre. In one embodiment, the microstructured fibre may be a photonic crystal fibre. | 11-19-2009 |
20090283672 | FRAGMENTATION OF ANALYTE IONS BY COLLISIONS IN RF ION TRAPS - Analyte ions, particularly biopolymer ions, stored in an RF ion trap are ergodically fragmented by bombarding the analyte ions with collision ions, for example medium-mass, mono-atomic ions having a charge of opposite polarity to the charge of the analyte ions. Since the analyte ions are not fragmented by accelerating and/or exciting them to oscillations, as is the case with conventional collision-induced dissociation, the RF voltage of the ion trap can be set low enough that daughter ions with light charge-related masses that are produced by the fragmentation can also remain trapped in the ion trap. | 11-19-2009 |
20090283673 | METHODS AND SYSTEMS FOR ANALYSIS AND CORRECTION OF MASS SPECTROMETER DATA - A background component of reporter ion signals is determined by fitting a distribution function. A plurality of samples that include a protein labeled with a plurality of isobaric reporter ions is analyzed at a plurality of different times using a mass spectrometer, producing a plurality of mass spectra for the plurality of isobaric reporter ions. A cumulative distribution is calculated for an inverse coefficient of differential expression of the plurality of mass spectra using a processor. A Pearson Type IV distribution shifted by a constant value is fitted to the cumulative distribution and the constant value is solved for using the processor. A background component for each spectrum of the plurality of mass spectra is calculated from the constant value, a calculated coefficient of differential expression for each spectrum, and an average reporter ion signal value for each spectrum using the processor. | 11-19-2009 |
20090289182 | Biomarkers of ionizing radiation - The present invention provides novel radiation associated markers. The radiation associated markers may be one or more of albumin, LTGF-β, or any protein or peptide listed in any one of Tables 1, 2, 3, 4, 5, and 6 provided herein. The present invention also provides methods of assessing exposure to ionizing radiation by determining the presence of one or more radiation associated markers. The methods may optionally include quantifying one or more of the radiation associated markers. The methods may further include comparing the amount of one or more radiation associated markers in the sample determined to be present in the sample with either (i) the amount determined for temporally matched, normal samples or (ii) the amount determined for samples obtained from individuals or subjects that have not been exposed to an elevated level of ionizing radiation. The present invention further provides a method of predicting outcome in a subject after exposure to elevated levels of ionizing radiation. Further, the present invention provides a method of determining the amount of radiation therapy that has been delivered to a particular tissue. Also, the present invention provides kits for assessing the likelihood of significant damage, death, illness or medical complications post exposure to elevated levels of ionizing radiation by determining the presence or absence or by quantifying the amount of one or more radiation associated markers. | 11-26-2009 |
20090289183 | SAMPLE PROCESSING SYSTEM AND SAMPLE PROCESSING METHOD FOR TRACE DETECTOR - A sample processing system and a sample processing method for a trace detector are disclosed. The system comprises a sampling substrate for collecting a substance or substances from the surface of an object to be tested by contacting the sampling substrate with the surface of the object, and a trace detector. The trace detector includes a sample feeding device provided with a sample feeding part. The substance collected by the sampling substrate can be transferred to a surface of the sample feeding part so that the substance transferred to the surface of the sample feeding part can be detected. With the configuration of some embodiments of the present invention, a sampling substrate made of chemical fiber is used to collect a sample from the surface of an object to be tested by contacting the sampling substrate with the surface of the object to be tested. The sample collected by the sampling substrate is mechanically transferred to a metal film or mesh of the sample feeding device of the trace detector. Then, the metal film or mesh of the sample feeding device is heated to vaporize the sample and to release the sample vapor into the trace detector. Therefore, the efficiency of sample collection and desorption processes can be improved. In addition, the direct heating of a sampling substrate can be avoided so as to decrease the interference of the sampling substrate with trace detection. | 11-26-2009 |
20090289184 | METHOD FOR THE ANALYSIS OF TISSUE SECTIONS - The present invention relates to a method for the histologic classification of a tissue section. The method includes acquiring a mass spectrometric image and a light-optical image of the same tissue section (the optical image having a higher spatial resolution than the mass spectrometric image) and combining optical information on the structures of a subarea of the tissue section with mass spectrometric information on the subarea (the structures not being spatially resolved in the mass spectrometric image). | 11-26-2009 |
20090294642 | Mass Spectrometer - A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser ( | 12-03-2009 |
20090294643 | REAL-TIME CONTROL OF ION DETECTION WITH EXTENDED DYNAMIC RANGE - In a method controlling an ion detector, one or more ion input signals are received at the ion detector. A data point indicative of an intensity of at least one of the received ion input signals is acquired. Asynchronously with acquiring the data point, a drive voltage applied to the ion detector is regulated to operate the ion detector at a gain optimal for the intensity of at least one of the received ion input signals. An ion detector for implementing the method is also provided. | 12-03-2009 |
20090294644 | DYNAMIC MULTIPLEXED ANALYSIS METHOD USING ION MOBILITY SPECTROMETER - A method for multiplexed analysis using ion mobility spectrometer in which the effectiveness and efficiency of the multiplexed method is optimized by automatically adjusting rates of passage of analyte materials through an IMS drift tube during operation of the system. This automatic adjustment is performed by the IMS instrument itself after determining the appropriate levels of adjustment according to the method of the present invention. In one example, the adjustment of the rates of passage for these materials is determined by quantifying the total number of analyte molecules delivered to the ion trap in a preselected period of time, comparing this number to the charge capacity of the ion trap, selecting a gate opening sequence; and implementing the selected gate opening sequence to obtain a preselected rate of analytes within said IMS drift tube. | 12-03-2009 |
20090294645 | ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA - Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data. | 12-03-2009 |
20090294646 | Mass Spectrometer - An electron capture dissociation device to implement a combination of electron capture dissociation and collision dissociation and a mass spectrometer with the use thereof are provided. This device includes a linear ion trap provided with linear multipole electrodes applied with a radio frequency electric field and wall electrodes that are arranged on both ends in the axis direction of the linear multipole electrodes, have holes on the central axis thereof, and generate a wall electric field by being applied with a direct-current voltage, a cylindrical magnetic field-generating unit that generates a magnetic field parallel to the central axis of the linear multipole electrodes and surrounds the linear ion trap, and an electron source arranged opposite to the linear multipole electrodes with sandwiching one of the wall electrodes. The electron generation site of the electron source is placed in the inside of the magnetic field generated by the magnetic field-generating unit. | 12-03-2009 |
20090294647 | MEASURING THE MOBILITY OF MASS SELECTED IONS - In an ion mobility spectrometer (IMS) coupled to a mass spectrometer (MS), the ion current from a suitable ion source is modulated with an analog modulation having a smooth modulation function, whose instantaneous frequency varies with time over a wide frequency range. The modulated ion current is continuously fed through a mobility drift region into the mass spectrometer, where the temporally varying ion current profile of at least one ion species is measured. The mobility spectrum of the ion species is then generated by correlating its ion current time profile with the modulation function. | 12-03-2009 |
20090294648 | METHOD AND SYSTEM FOR PROVIDING A MODIFIER TO A CURTAIN GAS FOR A DIFFERENTIAL MOBILITY SPECTROMETER - A system including a differential mobility spectrometer is described as is a method of operating the system including the differential mobility spectrometer. The method and system involve a) providing ions to the differential mobility spectrometer; b) providing a drift gas to an inlet of the differential mobility spectrometer; c) adjusting a meter to define a selected volumetric flow rate for supplying a modifier liquid to the drift gas; and, d) supplying an actual volumetric flow rate of the modifier liquid to the drift gas, wherein the actual volumetric flow rate is within a percentage deviation from the selected volumetric flow rate | 12-03-2009 |
20090294649 | Method and Apparatus for Generation of Reagent Ions in a Mass Spectrometer - A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD). | 12-03-2009 |
20090294650 | Method And System For Vacuum Driven Differential Mobility Spectrometer/Mass Spectrometer Interface With Adjustable Resolution And Selectivity - A mass spectrometer system including a differential mobility spectrometer and a mass spectrometer at least partially sealed to, and in fluid communication, with, the differential mobility spectrometer, together with a related method, are provided. The mass spectrometer system can be operable to, and method can comprise, a) maintaining the differential mobility spectrometer at an internal operating pressure; b) providing ions to the differential mobility spectrometer; c) maintaining the mass spectrometer at a vacuum pressure lower than the internal operating pressure to draw a gas flow including the ions through the differential mobility spectrometer and into the vacuum chamber; and, d) modifying the gas flow between the differential mobility spectrometer and the mass spectrometer to change a gas flow rate through the differential mobility spectrometer. | 12-03-2009 |
20090294651 | EVALUATION OF FREQUENCY MASS SPECTRA - The invention relates to the evaluation of mass spectra from mass spectrometers in which ions are excited to mass-specific oscillating or orbiting motions, and the ion motion is recorded as a time signal. The invention provides methods to detect parameter drift that occurs during the recording of a time signal in such a “frequency mass spectrometer” by analyzing the instantaneous frequency or the phase spectrum of a frequency component, and provides a method to correct for influence of the frequency drift on the mass spectrum correspondingly. In one embodiment a Fourier transformation converts a measured time signal into a frequency spectrum and examines the phase spectrum of a frequency component to establish whether this phase spectrum deviates from the phase spectrum of a harmonic time signal. The phase spectrum of a harmonic time signal is either linear or constant. In another embodiment the time domain signal is processed using a Short Time Fourier Transformation function to determine an instantaneous frequency, which can be used to correct the parameter drift, yielding a corrected time signal. From the corrected time signal a mass spectrum with better mass resolution can be derived, as can be seen from corrected mass signal profile compared with uncorrected mass signal profile. | 12-03-2009 |
20090294652 | Electron Generation Apparatuses, Mass Spectrometry Instruments, Methods of Generating Electrons, and Mass Spectrometry Methods - Electron generation apparatuses are disclosed that can include a power source coupled to a first electrode, and a switch between the power source and the first electrode. Mass spectrometry instruments are disclosed that can include a power source coupled to a first electrode, and a switch between the power source and the first electrode. Methods of generating electrons are provided that can include generating different voltage differentials across a cell, with at least one of the voltage differentials generating electrons from gaseous material, and discharging at least some of the electrons from the cell. Mass spectrometry methods are also provided that can include providing sample proximate a glow discharge ionization source, and generating a pulse of electrons from the ionization source according to an ionization parameter to ionize at least a portion of the sample. | 12-03-2009 |
20090294653 | ION CONCENTRATION TRANSISTOR AND DUAL-MODE SENSORS - An ion concentration sensor produces a signal reflective of the ion concentration within a solution. The ion concentration sensor is based on an ion sensitive transistor having a solution input, a reference input, a diffusion input, and a diffusion output. The ion sensitive transistor is connected as a pass transistor, such that the diffusion output provides an electrical signal indicating an ion concentration in a solution contacting the solution input. | 12-03-2009 |
20090302207 | Spectroscopic determination of enantiomeric purity - A new method and strategy for the quantitative determination of enantiomeric purity that combines polarimetry, spectroscopy, and chemometric modeling. Spectral data is collected after a light beam is passed through a first polarimeter, a sample of a chiral compound, and a second polarimeter oriented at a 45 degree angle relative to the first polarimeter. The spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. | 12-10-2009 |
20090302208 | APPARATUS AND METHODS FOR LIQUID DROPLET DEPOSITION - A method of and an apparatus for generating droplets has a capillary tube mounted in a moveable member. The capillary tube is accelerated towards a plate, and then subject to rapid deceleration, e.g. by way of an impact, to promote separation of a droplet which is then deposited on the plate. The droplet can be entirely separated from the capillary tip before being deposited, or, for smaller droplets, the droplet merely extends from the capillary tip and is then drawn onto the plate by a wicking action. The plurality of capillary tubes can be mounted on the common support member to effect multiplexing of drops. | 12-10-2009 |
20090302209 | MASS SPECTROMETER - An ion guide or mass analyser ( | 12-10-2009 |
20090302210 | MASS SPECTROMETER - A mass spectrometer comprising a collision, fragmentation or reaction cell ( | 12-10-2009 |
20090302211 | METHOD AND DEVICE FOR DESORPTION IONIZATION BY LIQUID JET - The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method. | 12-10-2009 |
20090302212 | Electric field separator device and process - A process and device is provided for the separation of electronegative molecules from non electronegative molecules using electric fields. The molecules are ionized in a non thermal discharge plasma which produces negative and positive ions of the electronegative and non electronegative molecules. The ions are spatially separated by an average DC electric field. A means to filter is disposed in the path of the separated ions and it allows ions to pass through more easily than uncharged molecules. After the ions pass through the filter they are electrically neutralized back to uncharged molecules. | 12-10-2009 |
20090302213 | INTERACTIVE METHOD FOR IDENTIFYING IONS FROM MASS SPECTRAL DATA - A method for identifying ions that generated mass spectral data, comprises acquiring raw mass spectral data in profile mode containing at least one ion of interest; performing at least one of mass spectral calibration involving peak shape and a determination of actual peak shape function associated with the acquired raw mass spectral data; considering at least one possible elemental composition of the ion; calculating theoretical mass spectral data for said elemental composition using the actual peak shape function; performing a normalization between corresponding parts of the theoretical mass spectral data and that of the raw or calibrated mass spectral data; and displaying mass spectral congruence between at least two mass spectra where one spectrum is the normalized version of the other corresponding to said possible elemental composition. The unique display and method assist in readily identifying ions. A data storage medium having computer code thereon for causing a computer to performing the method; also in combination with a mass spectrometer. | 12-10-2009 |
20090302214 | ION IMPLANTING APPARATUS AND METHOD OF CORRECTING BEAM ORBIT - An extraction electrode of an ion source is dividedly configured by a first extraction electrode and a second extraction electrode. DC power supplies which form a potential difference between the electrodes, a camera which takes an image of the ion beam to output image data of the ion beam, and a rear-stage beam instrument which measures the beam current of the ion beam that has passed through the analysis slit are disposed. A step of adjusting an analysis electromagnet current so that the beam current measured by the rear-stage beam instrument is maximum, that of processing the image data from the camera to obtain the deviation angle of the ion beam entering the analysis slit from the design beam orbit, and that of, if the deviation angle is not within an allowable range, adjusting the potential difference between the electrodes so that the ion beam is bent to a direction where the deviation angle becomes small, by the potential difference are performed one or more times until the deviation angle is within the allowable range. | 12-10-2009 |
20090309016 | Method and apparatus for Detecting Explosives - An interface that couples SPME to IMS has been constructed and evaluated for the detection of the following detection taggants: 2-nitrotoluene (2-NT), 4-nitrotoluene (4-NT), and 2,3-dimethyl-2,3-dinitrobutane (DMNB). The interface was also evaluated for the following common explosives: smokeless powder (nitrocellulose, NC), 2,4-dinitrotoluene (2,4-DNT), 2,6-dinitrotoluene (2,6-DNT), 2,4,6-trinitrotoluene (2,4,6-TNT), hexahydro-1,3,5-trinitro-s-triazine (RDX), and pentaerythritol tetranitrate (PETN). The resultant SPME-IMS interface was found to extract volatile constituent chemicals and detection taggants in explosives from a headspace for subsequent detection in a simple, rapid, sensitive, and inexpensive manner. | 12-17-2009 |
20090309017 | MASS ANALYZING METHOD - When the analyzer provides the mass and composition formula of the product ion, which is probably produced in the process of a dissociation, through the input unit | 12-17-2009 |
20090309018 | MULTI-SOURCE PLASMA FOCUSED ION BEAM SYSTEM - The present invention provides a plasma ion beam system that includes multiple gas sources and that can be used for performing multiple operations using different ion species to create or alter submicron features of a work piece. The system preferably uses an inductively coupled, magnetically enhanced ion beam source, suitable in conjunction with probe-forming optics sources to produce ion beams of a wide variety of ions without substantial kinetic energy oscillations induced by the source, thereby permitting formation of a high resolution beam. | 12-17-2009 |
20090309019 | FAIMS Apparatus Comprising Source of Dry Gas - An ion mobility spectrometer has an inlet opening into an ionization region including a conventional ionization source. A series of several charged, circular electrode plates with aligned apertures extending therethrough provides a drift region on the opposite side of the ionization region from the inlet. A gas inlet connected to a source of clean, dry flushing gas opens between the ends of the drift region, with the gas flowing against the ion flow to one side to remove water molecules from the analyte. Gas flowing in the opposite direction is effective to help drive the dry analyte ions to an analysis region provided by two parallel asymmetric field plates. | 12-17-2009 |
20090309020 | Method and system for desorption atmospheric pressure chemical ionization - A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte. | 12-17-2009 |
20090314934 | MASS SPECTROMETER - A multi-turn Time of Plight mass analyser is disclosed comprising a first electric sector ( | 12-24-2009 |
20090321626 | LASER DESORPTION IONIZATION AND PEPTIDE SEQUENCING ON LASER INDUCED SILICON MICROCOLUMN ARRAYS - The present invention provides a method of producing a laser-patterned silicon surface, especially silicon wafers for use in laser desorption ionization (LDI-MS) (including MALDI-MS and SELDI-MS), devices containing the same, and methods of testing samples employing the same. The surface is prepared by subjecting a silicon substrate to multiple laser shots from a high-power picosecond or femtosecond laser while in a processing environment, e.g., underwater, and generates a remarkable homogenous microcolumn array capable of providing an improved substrate for LDI-MS. | 12-31-2009 |
20090321627 | METHOD AND SYSTEM FOR HIGH THROUGHPUT MASS ANALYSIS - The invention relates to a test method, especially for mass spectroscopy of biomolecules, including the following steps: one or several samples ( | 12-31-2009 |
20090321628 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T | 12-31-2009 |
20090321629 | MASS SPECTROMETRIC DETECTION OF MATERIAL TRANSFERRED TO A SURFACE - The present invention provides methods for using detection methods, including mass spectrometry methods such as SELDI-TOF-MS, to detect and analyze molecules directly transferred from a sample to a surface to form a molecular print of the sample. Methods and compositions of the invention can be used to produce spatially and non-spatially oriented molecular prints for detection using methods such as mass spectrometry. Methods and compositions of the invention encompass molecular printing of tissues, cells and gels onto surfaces. | 12-31-2009 |
20090321630 | POST-DECEL MAGNETIC ENERGY FILTER FOR ION IMPLANTATION SYSTEMS - A system and method for magnetically filtering an ion beam during an ion implantation into a workpiece is provided, wherein ions are emitted from an ion source and accelerated the ions away from the ion source to form an ion beam. The ion beam is mass analyzed by a mass analyzer, wherein ions are selected. The ion beam is then decelerated via a decelerator once the ion beam is mass-analyzed, and the ion beam is further magnetically filtered the ion beam downstream of the deceleration. The magnetic filtering is provided by a quadrapole magnetic energy filter, wherein a magnetic field is formed for intercepting the ions in the ion beam exiting the decelerator to selectively filter undesirable ions and fast neutrals. | 12-31-2009 |
20090321631 | LOW-INERTIA MULTI-AXIS MULTI-DIRECTIONAL MECHANICALLY SCANNED ION IMPLANTATION SYSTEM - An ion implantation system configured to produce an ion beam is provided, wherein an end station has a robotic architecture having at least four degrees of freedom. An end effector operatively coupled to the robotic architecture selectively grips and translates a workpiece through the ion beam. The robotic architecture has a plurality of motors operatively coupled to the end station, each having a rotational shaft. At least a portion of each rotational shaft generally resides within the end station, and each of the plurality of motors has a linkage assembly respectively associated therewith, wherein each linkage assembly respectively has a crank arm and a strut. The crank arm of each linkage assembly is fixedly coupled to the respective rotational shaft, and the strut of each linkage assembly is pivotally coupled to the respective crank arm at a first joint, and pivotally coupled to the end effector at a second joint. | 12-31-2009 |
20100001180 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined. | 01-07-2010 |
20100001181 | Interfacing Low-Flow Separation Techniques - A capillary column, and method for forming a capillary column, in which the capillary column comprises at least one porous segment at a terminus of the capillary column, wherein the at least one porous segment is formed by exposing the segment to one or more of a solution of acid, base, and a mechanical tool. | 01-07-2010 |
20100012830 | IONIZATION SOURCE APPARATUS AND METHOD FOR MASS SPECTROMETRY - The invention provides an ionization source for mass spectrometers named Universal Soft Ionization Source (USIS), wherein the ionization chamber combines various physical effects including InfraRed and UltraViolet normal or laser light, ultrasound, electrostatic potential and differential temperature to analyze polar, non-polar, low, medium or high molecular weight molecules, in order to ionize a variety of compounds. | 01-21-2010 |
20100012831 | Three-Dimensional Molecular Imaging By Infrared Laser Ablation Electrospray Ionization Mass Spectrometry - The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI). | 01-21-2010 |
20100012832 | METHOD OF SEPARATING PHOSPHORYLATED PEPTIDE OR PHOSPHORYLATED PROTEIN - According to the present invention, phosphorylated peptides and/or phosphorylated proteins are specifically separated. A sample containing a phosphorylated peptide and/or a phosphorylated protein is supplied to a separation unit filled with a metal oxide in the presence of an aliphatic hydroxycarboxylic acid. Upon separation of a phosphorylated peptide and/or a phosphorylated peptide with the use of a separation unit filled with a metal oxide, adsorption of carboxylic acid to an acidic peptide can be prevented in the presence of aliphatic hydroxycarboxylic acid. In addition, aliphatic hydroxycarboxylic acid does not inhibit adsorption of a phosphorylated peptide and a phosphoric acid group in the phosphorylated peptide to a metal oxide. | 01-21-2010 |
20100019140 | OPEN PROBE METHOD AND DEVICE FOR SAMPLE INTRODUCTION FOR MASS SPECTROMETRY ANALYSIS - An open probe method for sample introduction into a mass spectrometer is disclosed, comprising the steps of: loading a sample holder with sample compounds to be analyzed; heating a probe oven; introducing said sample compounds in said sample holder into said heated probe oven; flowing inert gas into said heated probe oven; vaporizing said sample in said heated probe oven by the combined effect of oven temperature and inert gas flow; entraining said vaporized sample in said inert gas; and, transferring said vaporized sample in inert gas into an ion source of a mass spectrometer; wherein said heated probe oven remains open to the ambient atmosphere during sample introduction and analysis; said inert gas is flowing in said heated probe oven in two directions of a transfer line to a mass spectrometer ion source and to the oven opening; said vaporized sample in inert gas is transferred through a heated transfer line directly into the ionization chamber of an ion source of a mass spectrometer. An apparatus for this method of sample introduction is also disclosed. The primary advantage of this method and apparatus is that the heated probe oven remains open to the ambient atmosphere during sample introduction and analysis thereby enabling faster sample analysis. | 01-28-2010 |
20100019141 | ENERGY CONTAMINATION MONITOR WITH NEUTRAL CURRENT DETECTION - This energy contamination monitor has an ionization apparatus configured to ionize the neutral particles in an ion beam. Neutral particles are ionized, separated based at least in part upon different transit times over a distance, and measured with the Faraday electrode based at least in part upon the different transit times. The energy contamination monitor can distinguish between fast and slow neutral particles. | 01-28-2010 |
20100019142 | YTTRIA-METAL THERMIONIC FILAMENTS - A thermionic electron source comprises a nonlinear metallic substrate, a coating of yttria deposited on the substrate, and a current source configured to drive current through the metallic substrate. | 01-28-2010 |
20100032558 | Mass Spectrometry Assay for Plasma-Renin - Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample. | 02-11-2010 |
20100032559 | VARIABLE ENERGY PHOTOIONIZATION DEVICE AND METHOD FOR MASS SPECTROMETRY - A mass spectrometer using a variable energy photoionization device for ionizing and/or cleaving molecules is disclosed. The device permits ionizing photon wavelengths to be selected from a range of wavelengths allowing the ionizing photon energies to be tuned so as to ionize molecules without excessive fragmentation or to cleave molecules in a controlled manner by breaking only certain molecular bonds. Selection of the wavelengths is afforded by the choice of a plasma-forming gas combined with windowlessly radiating the ionizing photons from a plasma chamber. A method of mass spectrometry featuring selected ionizing photon wavelengths is also disclosed. | 02-11-2010 |
20100032560 | SMOKE DETECTOR AND IONISATION APPARATUS - A smoke detector comprises a soft x-ray source ( | 02-11-2010 |
20100038529 | METHOD OF PREPARING SAMPLE FOR MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY AND MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY - It is intended to provide a method of preparing sample for matrix-assisted laser desorption/ionization mass spectrometry using a matrix capable of generating preferred crystals that cause effective ionization of a molecule to be measured. A method of preparing a sample for matrix-assisted laser desorption/ionization mass spectrometry comprising the steps of: preparing a solution of 2,5-dihydroxybenzoic acid of 40 mg/mL to saturated concentration as a matrix solution; and dispensing the matrix solution to a sample to be analyzed by using an inkjet mechanism, to crystallize the 2,5-dihydroxybenzoic acid. | 02-18-2010 |
20100044559 | METHOD AND APPARATUS FOR A DUAL GATE FOR A MASS SPECTROMETER - An ion gate apparatus for controlling the transmission of ion pulses between an origin and a destination in a mass spectrometer is disclosed, comprising: a first split gate having a length L | 02-25-2010 |
20100044560 | Method and Apparatus for Pyrolysis-Induced Cleavage in Peptides and Proteins - A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed. | 02-25-2010 |
20100044561 | APPARATUS COMPRISING AN ION MOBILITY SPECTROMETER - A mass spectrometer is disclosed comprising a first chamber ( | 02-25-2010 |
20100044562 | MASS-ANALYZING METHOD AND MASS SPECTROMETER - Based on the mass spectrum obtained by mass-analyzing a sample, the composition of the unknown substance is deduced, and after that, an MS/MS analysis is performed in which the unknown substance is set to be a precursor ion. Then, based on the peaks appearing on the MS/MS spectrum, the actually measured mass of each product ion is obtained (S | 02-25-2010 |
20100051799 | MULTI-CHANNEL DETECTION - A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has travelled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement. | 03-04-2010 |
20100051800 | Ion Mobility Spectrometers - An ion mobility spectrometer has a reaction region separated from a drift region by an electrostatic gate. A doping circuit supplies a dopant to the reaction region but the drift region is undoped. Two high field ion modifiers are located one after the other in the drift region. One ion modifier can be turned on to remove dopant adducts from the admitted ions, or both ion modifiers can be turned on so that the ions are also fragmented. In this way, several different responses can be produced to provide additional information about the nature of the analyte substance and distinguish it from interferents. | 03-04-2010 |
20100051801 | METHODS AND SYSTEMS FOR ANALYZING MEDICATION LEVELS IN A SAMPLE - Methods and systems for assessing patient compliance with opioid drug therapy are provided. A liquid chromatography tandem mass spectrometer (LC/MS/MS) can be used to simultaneously detect a set of measurements including an amount of at least ten opioids (and their metabolites) in a body fluids sample from a patient. The set of at least ten opioids can include at least oxymorphone and fentanyl. The amounts of opioids and their metabolites are analyzed. For example, the ratios of opioids and their respective metabolites can be used to determine which opioids a patient has been administered. A report of patient compliance is generated based on the set of measurements. | 03-04-2010 |
20100059671 | METHODS FOR DETECTING DEHYDROEPIANDROSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of DHEA in the sample. | 03-11-2010 |
20100059672 | Device and method for analyzing a sample - A device and method for analyzing a sample, in particular a sample which contains low-density materials, is provided. Ions of a predefined mass and/or a predefined elementary charge are selected from a plurality of ions. The selected ions are directed onto the sample for sample preparation. An electron beam is then directed onto the prepared sample and a spatial distribution of scattered electrons is measured. | 03-11-2010 |
20100065733 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator ( | 03-18-2010 |
20100065734 | PARTICLE SORTING APPARATUS AND METHOD - A particle sorting apparatus for sorting particles following a free flight trajectory including: a detector for detecting a characteristic of the particles before or after they enter the free flight trajectory; an ionization source that emits a stream of ions for selectively applying charge to particles following the free flight trajectory; a static electric field for deflecting particles that have been charged by the ionization source; and means for deflecting the stream of ions emitted from the ionization source between a first orientation in which the stream of ions does not intersect the free flight trajectory and a second orientation in which the stream of ions does intersect the free flight trajectory depending on whether a particle following the free flight trajectory is detected as having the characteristic or not. | 03-18-2010 |
20100065735 | DEVICE FOR MASS SPECTROMETRY, AND MASS SPECTROMETRY APPARATUS AND METHOD - In a device for mass spectrometry, an analyte contained in a sample is desorbed from a surface of the device by irradiating the sample in contact with the surface with measurement light. The device includes a micro-structure having a plurality of metal bodies on a surface of a substrate, and the plurality of metal bodies have sizes that can excite localized plasmons by irradiation with the measurement light. Further, the device includes an initiator fixed at least to a part of a surface of the micro-structure. | 03-18-2010 |
20100065736 | METHOD FOR QUANTIFICATION OF ANALYTES IN A TITANIUM, TIN OR SILICON TETRACHLORIDE SAMPLE - This disclosure relates to a method for detecting at least one analyte in a tetrachloride sample comprising titanium, tin or silicon tetrachloride; comprising,
| 03-18-2010 |
20100072358 | PORTABLE LOEB-EIBER MASS SPECTROMETER - A portable mass spectrometer including an ion source, an ion detector, and a Loeb-Eiber style high-pass ion separator comprising an array of wires. The array can have first and second sets of wires where the distance between adjacent wires is less than the diameter of each of the wires. An electrical generator can be configured to create an electrical current and supply the electrical current to the first set of wires while the second set of wires remains grounded. | 03-25-2010 |
20100072359 | PORTABLE LIGHT EMITTING SAMPLING PROBE - An apparatus for heating a surface to liberate at least one analyte for detection thereof includes a source of energy to irradiate the surface and a collector to collect at least one gas from the surface, the at least one gas being capable of including the a least one liberated analyte. The apparatus further includes a detector linked to the collector to detect the presence of the at least one liberated analyte wherein the detection is used to control the power of the energy source by utilizing feedback relating to at least one condition of the surface. | 03-25-2010 |
20100072360 | Mass Spectrometer - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell ( | 03-25-2010 |
20100078550 | Method and apparatus for embedded heater for desorption and ionization of analytes - A heated DESI spray device provides improved resolution or control of analyte desorption at a target locus on a sample. Heating controls spot size and enhances resolution in an imaging mode without impairing signal level. Additionally or alternatively the heated DESI spray may control desorption kinetics of a target analyte or otherwise control analyte discrimination in detection mode. One embodiment of the DESI spray is heated by heating nebulizing gas that accompanies the electrosprayed solvent. Another embodiment heats a separate gas stream that transports or directs desorbed material to the ion aperture of an analysis instrument. Heating may reduce size of primary droplets, alter the impact dynamics or the energy delivered by the spray to the surface, reduce size of secondary droplets and/or assure desolvation, improve species selectivity or otherwise affect sampling and enhance the ion signal level. | 04-01-2010 |
20100078551 | Method, System And Apparatus For Multiplexing Ions In MSn Mass Spectrometry Analysis - A method and apparatus for multiplexing ions in an MSn mass spectrometer is provided. Ion are filtered to produce a group of ions of interest, the group of ions below a space charge limit of the MSn mass spectrometer. At least a portion of the group of ions are fragmented to form a fragmented group of ions. At least a portion of the fragmented group are stored such that a plurality of portions of the fragmented group can be sequentially selected for mass spectrometry analysis. Each of the plurality of portions of the fragmented group are sequentially selected and re-fragmented prior to mass spectrometry analysis. Each of the plurality of portions of the fragmented group are analyzed, via mass spectrometry, once each of the plurality of portions of the fragmented group has been fragmented. | 04-01-2010 |
20100084545 | Methods for Detecting Vitamin C by Mass Spectrometry - Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample. | 04-08-2010 |
20100084546 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 04-08-2010 |
20100084547 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals ( | 04-08-2010 |
20100090099 | Method and apparatus of uniform gas-phase molecular matrix deposition for imaging mass spectrometry - Disclosed are apparatus and methods for depositing solvent-free molecules on surfaces of samples, with particular application to imaging mass spectrometry. A vacuum chamber is configured to have controllable matrix translation apparatus for controlling the position of one or more solvent-free matrices within the chamber. Sublimation apparatus is used to sublimate molecules from the solid phase matrices. One or more samples are placed separately from the solvent-free matrices within the chamber. Condensation apparatus individually cools the samples to deposit sublimated molecules on the samples. Controllable sample translation apparatus is used to control the position of the samples within the chamber. Rotatable sample holding apparatus may be used to hold and move the samples to allow deposition of molecules on multiple samples at substantially the same time. Rotatable matrix holding apparatus may also be used to hold and move a plurality of matrices to create a homogenous mixture of molecules that are deposited onto one or more samples. As surface characterization system may be used to monitor deposition of the molecules to determine their thickness and roughness. A computer may be configured to control the matrix translation apparatus, the sublimation apparatus, the condensation apparatus, and the sample translation apparatus to provide for automated deposition of solvent-free molecules on the samples. | 04-15-2010 |
20100090100 | Spectrometer Apparatus - An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude, of an ion peak detected at the far end of the drift region. | 04-15-2010 |
20100090101 | GOLD IMPLANTATION/DEPOSITION OF BIOLOGICAL SAMPLES FOR LASER DESORPTION TWO AND THREE DIMENSIONAL DEPTH PROFILING OF BIOLOGICAL TISSUES - The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer. | 04-15-2010 |
20100096542 | ATMOSPHERIC PRESSURE ION SOURCE FOR MASS SPECTROMETRY - A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control. | 04-22-2010 |
20100096543 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed wherein the time period between successive orthogonal acceleration pulses is less than the time of flight of ions having the maximum mass to charge ratio of interest. As a result, some ions are subject to wrap-around and will appear in a subsequent mass spectrum. Mass spectra obtained at two different sampling rates may be compared and mass peaks relating to ions which have and have not been subject to wrap-around may be identified. | 04-22-2010 |
20100096544 | Surface Sampling Probe for Field Portable Surface Sampling Mass Spectrometer - A portable detection device includes a surface sampling probe connected to a mass spectrometer, preferably mounted on a portable cart, and a transfer line for transporting samples from the probe to the mass spectrometer. The surface sampling probe is formed from a circular block or disk of metal such as copper and is provided with various holes in which cartridge heaters are located. The disk is preferably electroplated with nickel and then gold to allow for efficient heat transfer to the surface to be sampled. With this arrangement, in addition to other advantages, the presence of very low volatile or non-volatile materials may be determined. | 04-22-2010 |
20100096545 | Method of Processing and Storing Mass Spectrometry Data - A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data. | 04-22-2010 |
20100096546 | Solution Analysis Using Atmospheric Pressure Ionization Techniques - A chemical detection system is disclosed. The chemical detection system includes an atmospheric pressure ionization (API) source that produces an API stream, a sample delivery system that delivers a liquid sample in a continuous manner to the API stream, an ion detector capable of detecting a molecule of interest and a control device. Also disclosed is a method for detecting a chemical of interest in a liquid sample. | 04-22-2010 |
20100102218 | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG - Methods of quantifying a N | 04-29-2010 |
20100108875 | METHOD OF ANALYZING MINUTE QUANTITY OF CONTENT - A sample preparation for analyzing a minute quantity of a content included in a material is performed by short-time extraction treatment without long-time extraction treatment, and the minute quantity of the content in the material is rapidly analyzed. The method of analyzing a minute quantity of a content includes mounting on a sample table a sample piece of a material to be analyzed; dropping onto the sample table the solvent for extracting the content from the sample piece, and injecting the solvent into a gap between the sample table and the sample piece; maintaining at room temperature the solvent injected into the gap between the sample table and the sample piece, and, with the solvent maintained in the gap between the sample table and the sample piece, extracting the content from the sample piece; and analyzing the content extracted from the sample piece. | 05-06-2010 |
20100108876 | Mass Spectral Analysis Of Complex Samples Containing Large Molecules - The present invention provides, inter alia, methods of analyzing mass spectral data based on charge states of analyte ions. In some embodiments, the methods can be used for differential profiling of samples, such as comparing a sample comprising a given compound and a sample comprising metabolites of the same compound. The methods can also be used to identify and isolate biomarkers. Systems for performing the methods, as well as computer-readable media for performing the methods, are also described. | 05-06-2010 |
20100108877 | ION MOBILITY BASED SEPARATION METHODS AND APPARATUS - The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance. | 05-06-2010 |
20100116980 | Means for identifying a strain isolated from a clinical sample at the species and/or subspecies level - The invention relates to a method for identifying a strain isolated from a clinical sample, at the species and/or subspecies level, using MALDI-TOF-MS analysis comprising a step of classifying the germ in a group before performing the MALDI-TOF-MS analysis | 05-13-2010 |
20100116981 | METHOD AND SYSTEM FOR MASS SPECTROMETRY DATA ANALYSIS - In the process of identifying a protein by analyzing and processing mass spectrum data obtained for each micro area (pixel) created by subdividing a two-dimensional area on a sample, mass windows including a peak or peaks on the mass spectrum of each pixel are set (S | 05-13-2010 |
20100123073 | ELECTRON CAPTURE DISSOCIATION IN A MASS SPECTROMETER - A mass spectrometer, that may be a time of flight mass spectrometer, has a source of ions having desired characteristics. The mass spectrometer section includes a modulator and first and second apertures on opposite sides of the modulator, with the first aperture providing a connection to the source of ions. A cell is connected to the modulator of the time-of flight mass spectrometer section by the second aperture, whereby, in use, ions from the source of ions can pass through the first aperture, the modulator and the second aperture into the cell, for capture of electrons or collision with a gas, to generate daughter ions, and the daughter ions are passed back into the time-of-flight or other mass spectrometer section for analysis. | 05-20-2010 |
20100123074 | DETECTION METHOD OF AIRBORNE NOXIOUS SUBSTANCE - Provided is a method for detecting an airborne noxious substance using radio-frequency inductive coupled plasma-mass spectroscopy (ICP-MS). The method includes: supplying a gas to be detected to a radio-frequency inductive coupled plasma; supplying oxygen gas to the gas introduced to the plasma to generate the oxide ion of a noxious element; and detecting the mass of the oxide ion of the noxious element. The method requires no separate pretreatment for detecting an airborne noxious substance, uses the ambient air itself as an analyte, and allows detection of the existence and amount of a noxious substance with high accuracy in a rapid and simple manner. | 05-20-2010 |
20100123075 | ULTRAFAST LASER SYSTEM FOR BIOLOGICAL MASS SPECTROMETRY - One aspect of the system provides the use of a laser with a mass spectrometer. Another aspect of the present application employs a laser emitting a pulse of less than one picosecond duration into an ion-trap mass spectrometer. In yet another aspect of the present application, a femtosecond laser beam pulse is emitted upon an ionized specimen to remove at least one electron therefrom. | 05-20-2010 |
20100127163 | ION MOBILITY MEASUREMENTS FOR FORMATION FLUID CHARACTERIZATION - Methods and related apparatuses for chemically analyzing at least one sample of fluid, such that a gas flow of at least one fluid sample is directed into a mixing region of an ion mobility device, wherein the mixing region is in communication with at least one container having at least one other fluid. Further, creating an ion flow of gaseous ions, a mixture of gaseous ions or a gaseous neutral species from the at least one sample and the at least one other fluid. Further still, injecting the ion flow from the mixing region into at least one ion mobility assembly of the ion mobility device, the at least one ion mobility assembly comprising at least one mobility tube; and, detecting the ions from the ion flow exiting the ion mobility assembly. | 05-27-2010 |
20100127164 | Ion Mobility Spectrometer Comprising Two Drift Chambers - An ion mobility spectrometer has two drift chambers and a common, doped reaction region. Each drift chamber includes an ion modifier, such as one that fragments the doped ions by a high electrical field. One of the drift chambers is doped and the other is undoped. In this way, the dopant adducts are removed by the modification process but then recombine with dopant only in the doped chamber so that different outputs are produced by the two drift chambers. | 05-27-2010 |
20100127165 | MASS SPECTROMETY WITH SELECTIVE ION FILTRATION BY DIGITAL THRESHOLDING - The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process. | 05-27-2010 |
20100127166 | METHOD AND APPARATUS FOR CHEMICAL AND BIOLOGICAL SAMPLE SEPARATION - The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. The invention allows detecting and confirming samples using one or more ion mobility based spectrometers. | 05-27-2010 |
20100133429 | METHOD OF CONTROLLING MASS SPECTROMETER AND MASS SPECTROMETER - A method of controlling a mass spectrometer comprises the steps of: supplying a current to a cathode electrode of an ion source having the cathode electrode and an anode electrode, and ionizing a molecules of a gas to be measured; selecting ions generated in the ion source by mass-to-charge ratio; and detecting an ion current value of the selected ions. When a partial pressure of the gas to be measured is measured based on a detection result of the ion current value, a cathode current is supplied to the cathode electrode such that an emission current flowing between the cathode electrode and the anode electrode becomes constant. When a partial pressure of the gas to be measured is not measured, a constant current having a current value less than that of the cathode current is supplied to the cathode electrode. | 06-03-2010 |
20100133430 | MS METHODS TO EVALUATE GLYCANS - The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans. | 06-03-2010 |
20100140465 | Apparatus and Method for Filtration to Enhance the Detection of Peaks - Filters and methods for enhancing the identification of peaks in mass spectroscopy data are disclosed. In particular, the invention encompasses methods using hole array filters for the purpose of purifying biological fluids to be used in generating mass spectra data. The methods of the present invention may be used for enhancing relevant peaks in mass spectra data for use in identifying and diagnosing diseases or for predicting responses to particular disease treatments. | 06-10-2010 |
20100140466 | RADICAL ANIONS FOR ELECTRON TRANSFER DISSOCIATION - Radical anions for use in the fragmentation of positively charged biopolymer ions by means of electron transfer are produced from substances previously unknown for use as ETD production substances. The inventive substances produce radical anions that lead to electron transfer dissociations with a high yield of fragment ions. The substances have high volatility that allows them to be kept in unheated containers outside the vacuum system and transported into the vacuum system to an in vacuum electron attachment ion source via unheated lines and low molecular weights that allow the measurement of even very light fragment ions. In one embodiment, a suitable substance is 1-3-5-7-cyclooctatetraene. | 06-10-2010 |
20100140467 | ANALYSIS OF AMINO ACIDS IN BODY FLUID BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY - This disclosure provides methods for quantifying individual amino acids in various bodily fluids obtained from a human patient. Also provided are reference ranges for normal amino acid levels in the various bodily fluids (e.g., blood plasma, urine, cerebrospinal fluid, and saliva) and for various age groups (e.g., neonates, infants, children, and adults). | 06-10-2010 |
20100140468 | APPARATUS FOR HOLDING SOLIDS FOR USE WITH SURFACE IONIZATION TECHNOLOGY - The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection. | 06-10-2010 |
20100148052 | ANALYTICAL CARRIER AND APPLICATION THEREOF - A carrier that is intended for retaining a subject of analysis and contains an electrically conductive material having a nonmetallic matrix. This analytical carrier containing an electrically conductive material is useful in situations where operations of the carrier, such as applying voltage thereto, are necessary to feed, retain or analyze the subject of analysis. The analytical carrier according to the present invention can be used as, for example, an alternate or a part of a metal sample plate for MALDI-TOFMS or other mass spectrometric analyses. | 06-17-2010 |
20100148053 | Flat Plate FAIMS with Lateral Ion Focusing - A high field asymmetric waveform ion mobility spectrometer (FAIMS) includes at least two focusing electrodes that are separated one from the other by a gap, which decreases in width along a direction of ion flow. Within the gap is disposed an electrode assembly including a first electrode and a second electrode, approximately flat surfaces of the first and second electrodes facing one another so as to define a space of approximately uniform thicknesses therebetween. During use electrical signals are applied via an electrical contact on at least one of the first electrode and the second electrode, and on each one of the at least two focusing electrodes. The electrical signals are for establishing electrode electric field conditions within the space between the first electrode and the second, for selectively transmitting ions therethrough and for directing the selectively transmitted ions in a direction away from one of the at least two focusing electrodes and toward a central portion of the space. | 06-17-2010 |
20100148054 | MASS SPECTROMETRY ASSAY FOR THIOPURINE-S-METHYL TRANSFERASE ACTIVITY AND PRODUCTS GENERATED THEREBY - Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample. | 06-17-2010 |
20100148055 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample. | 06-17-2010 |
20100148056 | Mass Spectrometer - A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap ( | 06-17-2010 |
20100148057 | Device And Method For Analyzing A Sample - Embodiments of the invention relate to a device for analysing a sample surface Comprising an outlet and a frame. The outlet is for forming a jet of gas, the jet forming a sampling region for receiving one or more sample surfaces, and the frame holding the outlet and being adapted to receive a detector means. The detector means has an inlet. In use, the jet produces desorbed sample from sample surfaces received in the sample area. At least a portion of the desorbed sample is ionized to produce one or more sample ions. The frame holds the outlet with respect to the sample ions and produce a signal indicative of the composition of the sample ions. | 06-17-2010 |
20100148058 | METHOD AND APPARATUS FOR CHEMICAL AND BIOLOGICAL SAMPLE SEPARATION - The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement. | 06-17-2010 |
20100148059 | High sensitivity mass spectrometer interface for multiple ion sources - An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway. | 06-17-2010 |
20100155590 | LABELED TRANSITION METAL COMPLEXES - The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities. In addition, the present invention also relates to a set of at least two of said transition metal complexes of different molecular mass, to transition metal complexes comprising different stable isotopes, to chemical or biological entities obtained by a method of the invention and to a kit of parts supporting the use and/or methods of the invention. | 06-24-2010 |
20100155591 | Second ion mass spectrometry method and imaging method - The provision of a new method for analyzing organic molecules such as protein and endocrine disrupting chemicals with excellent sensitivity. A secondary ion mass spectrometry method using a heavy ion beam as a primary ion beam enables the detection of, for example, an organism-related material at the sub-amol level with high sensitivity. As a result, favorable imaging of an organism-related sample can be performed. | 06-24-2010 |
20100155592 | VITAMIN B2 DETECTION BY MASS SPECTROMETRY - Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques. | 06-24-2010 |
20100155593 | TIME-OF-FLIGHT SEGMENTED FARADAY - This measurement device is used to determine energy for charged particles. The measurement device includes two segments and a plate that define two thresholds or gaps. The current as a charged particle passes through these thresholds or gaps is measured. The measurement device then calculates the energy of the charged particles. Energy contamination also may be determined. | 06-24-2010 |
20100155594 | MASS SPECTROMETRY ASSAY FOR ESTROGENIC COMPOUNDS - Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17α-estradiol (E2a), 17β-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17α-dihydroequilin (EQa), 17β-dihydroequilin (EQb), Equilenin (EN), 17α-dihydroequilenin (ENa), 17β-dihydroequilenin (ENb), and Δ8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 06-24-2010 |
20100163720 | MEANS AND METHOD FOR DIAGNOSING DIABETES - The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes. Finally, the present invention pertains to a method for identifying diabetes-related metabolites. | 07-01-2010 |
20100163721 | SERUM PROTEOMICS SYSTEM AND ASSOCIATED METHODS - Methods for proteomic analysis are provided. For example, in one aspect a method for identifying and sequencing a peptide may include fractionating a biological sample containing a peptide of interest to at least partially isolate the peptide, obtaining mass spectra of the peptide, and accelerating the peptide into a collision chamber at a plurality of discrete collision energies for a discrete period of time to form a plurality of peptide fragments for each of the plurality of discrete collision energies. The method may further include obtaining a plurality of fragmentation mass spectra from the plurality of peptide fragments for each of the plurality of discrete collision energies, summing the plurality of fragmentation mass spectra from each of the plurality of discrete collision energies to form a plurality of discrete collision energy mass spectra, one discrete collision energy mass spectra from each discrete collision energy, summing the plurality of discrete collision energy mass spectra to form a final mass spectrum for the peptide fragments, and identifying a sequence of amino acids corresponding to the peptide from the final mass spectrum. | 07-01-2010 |
20100163722 | MASS SPECTROMETRY AND MASS SPECTROMETER USED FOR THE SAME - The present invention maintains a stable emission amount from an emitter. In an embodiment of the present invention, a solid sample or a liquid sample is heated to gasify an object to be measured contained in the solid sample or the liquid sample, thereby forming a neutral gaseous molecule, and a metal ion emitted from an emitter having an oxidized surface is attached to the neutral gaseous molecule to ionize the neutral gaseous molecule, which is subjected to mass spectrometry. The solid sample or the liquid sample is a sample that emits a reducing gas by heating. The heating for gasifying the object to be measured is performed at a temperature lower than the vaporization temperature of the solid sample or the liquid sample and not less than the vaporization temperature of the object to be measured, and an oxidizing gas is provided to the emitter. | 07-01-2010 |
20100163723 | MASS SPECTROMETER SYSTEM AND MASS SPECTROMETRY METHOD - A mass spectrometer system comprises a chamber having an ion emitting unit to emit metal ions in the chamber with a communicating hole; a neutral molecule introduction unit; another gas introduction unit; a controller controlling a temperature of a region where metal ions attach to the neutral molecules; and a mass analyzer for the neutral molecules with the metal ions, wherein plotting an attachment energy of the metal ions attached to the neutral molecules in the chamber along an abscissa and the temperature of the region where the metal ions attach to the neutral molecules along an ordinate, the controller adjusts the temperature of the region so as to fall within a range obtained by excluding a range corresponding to the temperature of the region from 150 to 200° C. from a range surrounded by the temperatures of the region [° C.]=150×attachment energy [eV], 100×attachment energy [eV]−50, and 20° C., and attachment energies [eV]=2.1 and 0.5. | 07-01-2010 |
20100171032 | SELF CALIBRATION APPROACH FOR MASS SPECTROMETRY - Methods for analyzing mass spectral data, include acquiring profile mode mass spectral data containing at least on ion of interest whose elemental composition is determined; obtaining a correct peak shape function based on the actually measured peak shape of at least one of the isotypes of the same ion of interest; generating at least one possible elemental composition for the ion of interest; calculating a theoretical isotope cluster by applying correct peak shape function to the theoretical isotope distribution; comparing quantiatively the corresponding parts of the theoretical isotope cluster to that from acquired profile mode mass spectral data to obtain at least one of elemental composition determination, classification, or quantitation for the ion. A computer for and a computer readable medium having computer readable code thereon for performing the methods. A mass spectrometer having an associated computer for performing the methods. | 07-08-2010 |
20100171033 | ION SOURCE VESSEL AND METHODS - An ion source and method for providing ionized particles to a molecular/atomic analyser, such as a mass spectrometer, are disclosed. The ion source includes a vessel defining a channel; a gas inlet extending from the gas source into the channel, for introducing a gas flow into the channel; a sample inlet extending into the channel for introducing sample within the channel; and an ionizer to ionize the sample in the channel. The vessel is sufficiently sealed to allow the channel to be pressurized, at a pressure in excess of 100 Torr. At least one gas source maintains the pressure of the channel at a pressure in excess of 100 Torr and the pressure exterior to the channel at a pressure in excess of 0.1 Torr and provides a gas flow that sweeps across the ionizer to guide and entrain ions from the ionizer to the outlet. | 07-08-2010 |
20100171034 | METHOD OF MANUFACTURING AN ANALYTICAL SAMPLE AND METHOD OF ANALYZING AN ANALYTICAL SAMPLE - A method of manufacturing an analytical sample by a secondary ion mass spectrometry method is provided, which comprises a step of forming a separation layer over a substrate, a step of forming one of a thin film and a thin-film stack body to be analyzed over the separation layer, a step of forming an opening portion in one of the thin film and the thin-film stack body, a step of attaching a supporting body to one of a surface of the thin film and a surface of a top layer of the thin-film stack body, and a step of separating one of the thin film and the thin-film stack body from the substrate. | 07-08-2010 |
20100176287 | DEVICE FOR SEPARATION AND MALDI ANALYSIS OF AN ANALYTE IN A SAMPLE - The present invention relates to a device for separating at least one analyte in a liquid sample and further analyzing said analyte by laser desorption/ionization (LDI) mass spectrometry. The invention is further concerned with the use of devices for separating at least one analyte in a liquid sample and subsequent determination of the presence and/or amount of said at least one analyte by LDI mass spectrometry. The invention is also concerned with a method for separating at least one analyte in a liquid sample and subsequent determination of the presence and/or amount of said at least one analyte by LDI mass spectrometry. | 07-15-2010 |
20100176288 | METHOD AND APPARATUS USEFUL FOR IMAGING - The present invention provides a method of generating ions from a sample, the method comprising the steps of (1) designating a plurality of sample target sites, and (2) for each of said plurality of sample target sites, generating ions from a plurality of locations associated with the sample target site, wherein said plurality of locations are selected automatically with reference to the said sample target site. Each of the plurality of sample target sites is associated with a discrete sample region, wherein the sample is part of a MALDI ion source and the plurality of discrete sample regions comprise regions of matrix, suitably formed by chemical inkjet printing. The plurality of locations can be at least 5 and preferably at least 10 locations, each of which can be selected randomly or in accordance with a predetermined pattern. Ions generated from the plurality of locations associated with each of the sample target sites are assigned only a single set of sample position coordinates, which coordinates correspond to those of the sample target site. This averaging technique leads to improved data reliability. | 07-15-2010 |
20100176289 | EXCITATION OF IONS IN ICR MASS SPECTROMETERS - In an ion cyclotron resonance mass spectrometer ions are excited into cyclotron orbits by an alternating current excitation signal having a nonlinear function of the excitation frequency vs. time in a “chirp.” Such an excitation signal produces transients which have no pronounced beats, even if mixtures of many ion species, all having the same mass differences, are present. The dynamic measuring range for the image currents can thus be better utilized. In particular, sum spectra of specified quality can be generated from a significantly smaller number of individual transients, and thus in a significantly shorter measuring time. | 07-15-2010 |
20100176290 | IONIZER FOR VAPOR ANALYSIS DECOUPLING THE IONIZATION REGION FROM THE ANALYZER - A method and apparatus are described to increase the efficiency with which a sample vapor is ionized prior to being introduced into an analyzer. Excellent contact between the vapor and the charging agent is achieved in the ionization chamber by separating it from the analyzer by means of a perforated impaction plate. As a result, some desired fraction of the gas going into the analyzer or coming out of the analyzer can be controlled independently from the flow of sample through the ionization chamber. Furthermore, penetration into said ionization chamber of said desired fraction of the gas going into or out of the analyzer is minimized by controlling the dimensions of said perforated impaction plate. Ions formed in the ionization chamber are driven partly by electric fields through said hole in said perforated impaction plate into the inlet to the analyzer. As a result, most of the gas sampled into the analyzer carries ionized vapors, even when the sample flow of vapor is very small, and even when the analyzer uses counterflow gas. | 07-15-2010 |
20100181473 | METHOD AND APPARATUS FOR THE ANALYSIS OF SAMPLES - The present invention relates to an apparatus and method for the analysis of ions in a mass spectrometer comprising; a means to remove material from the sample at a defined specific point, a means to change either discretely or continuously the said defined point of material removal, at least one ionisation means, at least one ion accelerator, at least one energy selective means, a time focus means, a pulse bunching means and a detection means. Said invention allows the mass of an to be analysed with respect to multiple positions on a sample of a material providing a method and apparatus that allows the effective three dimensional mapping of the sample in terms of its constituent parts, their corresponding distribution in those three dimensions in relation to each other and other points of interest on the said sample and also to retain important chemical information by permitting the analysis of whole and intact molecules present on the surface of or within the material sample. | 07-22-2010 |
20100181474 | Angled Dual-Polarity Mass Spectrometer - An angled dual-polarity mass spectrometer includes a dual-polarity ion generator, a first mass analyzer, and a second mass analyzer. The dual-polarity ion generator includes an ion source to generate positive ions and negative ions from a sample, and electrodes to generate electric fields for guiding the negative ions into a beam of negative ions and guiding the positive ions into a beam of positive ions. The first mass analyzer can analyze the negative ions, and the second mass analyzer can analyze the positive ions. The central axes of the first and the second mass analyzers are at an angle between 0 to 179 degrees. | 07-22-2010 |
20100187414 | Apparatus And Method For Identifying Peaks In Liquid Chromatography/Mass Spectrometry Data And For Forming Spectra And Chromatograms - Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to-charge ratios falling within a specified mass-to-charge ratio window. | 07-29-2010 |
20100193678 | APPARATUS AND METHODS FOR ANALYZING IONS - An apparatus ( | 08-05-2010 |
20100193679 | GUIDING CHARGED DROPLETS AND IONS IN AN ELECTROSPRAY ION SOURCE - Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter. | 08-05-2010 |
20100193680 | Mass Spectrometry - This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser. | 08-05-2010 |
20100200745 | ION GATE METHOD AND APPARATUS - The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described. | 08-12-2010 |
20100200746 | INTELLIGENTLY CONTROLLED SPECTROMETER METHODS AND APPARATUS - The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. | 08-12-2010 |
20100207020 | HIGH MASS RESOLUTION WITH ICR MEASURING CELLS - The compensation potentials on the compensation electrodes of an ICR measuring cell are sequentially adjusted so that an ICR measurement with the longest possible usable image current transient is produced. Then, subsequent ICR measurements are made using the ICR cell with the optimally adjusted compensation potentials. Depending on the kind of ion mixture involved, measurements with image current transients from 10 to more than 20 seconds long can be performed, from which mass spectra with a maximum mass resolution without peak coalescence can be obtained. | 08-19-2010 |
20100207021 | NANOPHOTONIC PRODUCTION, MODULATION AND SWITCHING OF IONS BY SILICON MICROCOLUMN ARRAYS - The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of laser light polarization and the angle of incidence. By providing photonic ion sources, this enables enhanced control of ion production on a micro/nano scale and direct integration with miniaturized analytical devices. | 08-19-2010 |
20100207022 | PLATFORM FOR FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY WITH ION PROPULSION MODES EMPLOYING GAS FLOW AND ELECTRIC FIELD - A differential ion mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) platform is disclosed that utilizes both gas flow and electric field, consecutively or simultaneously, to move ions through the analytical gap. The consecutive combination of flow and field enables rapid and flexible switching of the FAIMS stage “on” (for ion separation) and “off” (for high non-selective transmission) with no hardware modifications. This capability is needed for effective use of multidimensional instrument systems that couple FAIMS to mass spectrometry and/or conventional ion mobility spectrometry. The joint application of flow and field allows controlling the discrimination against high-mobility ions, maximizing it to remove the chemical noise or minimizing it to make the analyses of complex samples more predictable and uniform. | 08-19-2010 |
20100207023 | APPARATUS AND METHOD OF PHOTO FRAGMENTATION - A method of photo-fragmentation is provided generating a beam of ions from a sample with an ion source, filtering the beam of ions in a filtering region to select desired ions, and photo-fragmenting the desired ions in a photo-fragmentation region having a higher pressure than the filtering region to generate fragment ions predominantly by prompt fragmentation. An apparatus for photo-fragmentation is provided having an ion source configured to generate a beam of ions from a sample, a filtering region for selecting desired ions, a photo-fragmentation region having a higher pressure than the filtering region to generate predominantly prompt fragmentation of the selected desired ions, an inlet for providing gas to the photo-fragmentation region to maintain a pressure in the photo-fragmentation region that is higher than the pressure in the filtering region, and a photon source emitting a beam of light for photo-fragmenting the selected ions in the photo-fragmentation region. | 08-19-2010 |
20100213365 | SCREENING SYSTEM AND METHOD FOR OPERATING THE SAME - A method of operating a screening system includes applying an electromagnetic field to a subject in a region at least partially enclosed by electromagnetic shielding, and measuring an output from a sensor. The output is representative of an interaction of the electromagnetic field and the subject. A trace vapor is collected from the subject within the region, and the trace vapor is identified. Based on the measured sensor output and the identified trace vapor, whether a target material is associated with the subject is determined. | 08-26-2010 |
20100213366 | COUPLING BETWEEN AXISYMMETRIC DIFFERENTIAL MOBILITY ANALYZERS AND MASS SPECTROMETERS OR OTHER ANALYZERS AND DETECTORS - Prior work on differential mobility analysis (DMA) combined with mass spectrometry (MS) has shown how to couple the output of a planar DMA with the atmospheric pressure inlet of an atmospheric pressure ionization mass spectrometer (APCI-MS). However, because the ion inlet to APCI-MS instruments is a round orifice, while conventional DMA geometries make use of elongated slits, the coupling of both has attained less resolving power or tolerated a smaller sample flow rate than a DMA alone. The present invention overcomes these limitations with an axial DMA of cylindrical symmetry using more than two electrodes. The configuration is related to that previously proposed by Labowsky and Fernández de la. Mora (2004, 2006), where ions with a critical electrical mobility are brought into the symmetry axis of the DMA. Ions with this critical mobility are now optimally transmitted into the MS, with much higher resolution than possible in planar DMAs. In a preferred embodiment of this DMA facilitating DMA-MS coupling, one DMA electrode intersecting the symmetry axis is relatively planar. | 08-26-2010 |
20100213367 | Soft ablative desorption method and system - Methods and systems are provided for the soft desorption of analyte from a sample, in which an optical beam absorbed within an irradiate zone of the sample causes vibrational excitations of a component within the sample. The optical beam, providing sufficient energy to superheat the component, is provided for a time interval that is less than the time duration required for the loss of energy out of the irradiated zone due to thermal diffusion and acoustic expansion. The superheated component thus drives ablation within the irradiated zone, resulting in the soft desorption of analyte without ionization and fragmentation. The ejected ablation plume may be directed towards the inlet of a mass analysis device for detection of the desorbed analyte, which is preferably ionized by a linear resonant photo-ionization step. | 08-26-2010 |
20100213368 | Precise and thorough background subtraction - A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples. | 08-26-2010 |
20100219335 | Liquid Chromatography-Mass Spectrometry Analysis of Samples Using Ionic Eluent Comprising a Volatile Ionic Salt - The use of an ionic eluent in ion exchange chromatography for analysing a sample comprising an analyte, wherein the ionic eluent comprises a volatile ionic salt, in particular an ammonium salt, is described. Such eluents are shown to be compatible with mass spectrometry (MS), providing clean mass spectra of the analyte. Furthermore, eluates from ion exchange chromatography may be advantageously analysed with MS without additional on-line or off-line devices for desalting or suppressing salts in the eluent. Important information concerning the chemical structure and composition of a sample may therefore be obtained with ion chromatography-MS by utilising the invention. The invention also provides a method of analysing a sample (e.g. a vaccine) comprising an analyte (e.g. a saccharide) by ion chromotography-MS by employing an ionic eluent, wherein the ionic eluent comprises a volatile ionic salt. An apparatus for analysing a sample comprising an analyte is also disclosed. | 09-02-2010 |
20100219336 | IONIZATION PROBE ASSEMBLIES - The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose. | 09-02-2010 |
20100219337 | Method Of Mass Spectrometry And Mass Spectrometer - A mass spectrometer introducing ions produced at an ion source, and including quadrupole rods which have an inlet and an outlet and to which a radio-frequency voltage is applied, the mass spectrometer, i.e., a mass spectrometry device implemented by a linear trap which exhibits high ejection efficiency, high mass resolution, and low ejection energy, executes the following steps: Trapping at least part of the ions by a trap potential generated on the central axis of a quadrupole field, oscillating part of the trapped ions in an intermediate direction between the mutually-adjacent quadrupole rods, ejecting the oscillated ions by an extraction field, and detecting the ejected ions or introducing the ejected ions into another detection process. | 09-02-2010 |
20100219338 | MASS SPECTROMETRY ASSAY FOR PLASMA-RENIN - Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1 generated in the sample, which in turn is related to renin activity in the sample. | 09-02-2010 |
20100224774 | Electrode for influencing ion motion in mass spectrometers - An electrode for influencing ion motion in mass spectrometers, having a dielectric substrate and a conducting layer on portions of the substrate, wherein peripheral borders, edges or convex shapes of the conducting layer adjoin free regions of the substrate. According to the invention, a dielectric layer is provided on transitions from the conducting layer to the adjoining free regions of the substrate such that at least some of the peripheral borders, edges or convex shapes of the conducting layer are covered. | 09-09-2010 |
20100224775 | LASER SYSTEM FOR MALDI MASS SPECTROMETRY - Mass spectrometry with lasers generates ions from analyte molecules by matrix assisted laser desorption for a variety of different mass spectrometric analysis procedures. The mass spectrometers with laser systems supply laser light pulses having at least two different pulse durations, and mass spectrometric measuring techniques use the laser light pulses of different durations. The duration of the laser light pulses allows the characteristics of the ionization of the analyte molecules, particularly the occurrence of the ISD (in-source decay) and PSD (post-source decay) types of fragmentation, whose fragment ion spectra supply different kinds of information, to be adapted to the analytic procedure. | 09-09-2010 |
20100224776 | ION MOBILITY SPECTROMETER APPARATUS AND METHODS - An ion mobility spectrometer includes a protective housing. A drift tube having at least one inlet and at least one outlet confines a drift gas. An ion gate is positioned in the drift tube. The ion gate defines a reaction region and a drift region in the drift tube. An ion detector is positioned in the drift tube downstream of the ion gate at an end of the drift region. A helical resistive wire coil is positioned around the drift tube. A power supply generates an electric field in the helical resistive wire coil that rapidly controls the temperature of the drift gas. | 09-09-2010 |
20100230586 | METHOD AND APPARATUS FOR PROVIDING A SAMPLE FOR A SUBSEQUENT ANALYSIS - The invention relates to a method and an apparatus for providing a sample for a subsequent analysis of the sample, particularly for analyzing biomolecules, comprising the following steps: generating a free micro liquid jet in an environment having a predetermined pressure, wherein the micro liquid jet contains a carrier liquid and the sample to be analyzed, and dispersing the micro liquid jet into droplets containing the sample, wherein the environment surrounding the micro liquid jet is a gaseous environment in which the pressure is above vacuum conditions. | 09-16-2010 |
20100230587 | ELECTROSPRAY IONIZATION MASS SPECTROMETRY METHODOLOGY - A method of enhanced speciation of both positive and negatives species in an analyte is disclosed. The method can include producing a first analyte solution comprising an analyte composition and an effective amount of silver triflate, and analyzing the first analyte solution with an electrospray ionization mass spectrometer. The method can also include producing a second analyte solution comprising a portion of the analyte composition and an effective amount of a compound of formula I, and analyzing the second analyte solution with an electrospray ionization mass spectrometer. The compound of formula I is [NX | 09-16-2010 |
20100237232 | Apparatus & method for ion beam implantation using scanning and spot beams with improved high dose beam quality - An ion implantation apparatus with multiple operating modes is disclosed. The ion implantation apparatus has an ion source and an ion extraction means for forming a converging beam on AMU-non-dispersive plane therefrom. The ion implantation apparatus includes magnetic scanner prior to a magnetic analyzer for scanning the beam on the non-dispersive plane, the magnetic analyzer for selecting ions with specific mass-to-charge ratio to pass through a mass slit to project onto a substrate. A rectangular quadruple magnet is provided to collimate the scanned ion beam and fine corrections of the beam incident angles onto a target. A deceleration or acceleration system incorporating energy filtering is at downstream of the beam collimator. A two-dimensional mechanical scanning system for scanning the target is disclosed, in which a beam diagnostic means is built in. | 09-23-2010 |
20100237233 | ION OPTICS DRAIN FOR ION MOBILITY - A sample analysis system incorporates an ion removal mechanism for removing residual ions from the sample analysis system. The ion removal mechanism can be included in an ion optics assembly, which connects an ion mobility filter to a mass analyzer. A sample to be analyzed by the sample analysis system may be entered into an ion mobility filter. The ion mobility filter filters the ions of the sample and passes the filtered group of ions to the ion optics assembly. The ion optics assembly transports the filtered group of ions to a mass analyzer where some or all of the ions in the group are detected. The ion removal mechanism then removes all or substantially all residual ions from the ion optics that were left over from the first filtered group before a second filtered group is passed through. | 09-23-2010 |
20100237234 | LIQUID METAL ION SOURCE, SECONDARY IION MASS SPECTROMETER,SECONDARY ION MASS SPECTROMETRIC ANALYSIS METHOD AND USE THEREOF - A mass spectrometric method according to the Gentle SIMS (G-SIMS) method uses a liquid metal ion source which contains, on the one hand, a first metal with an atomic weight ≧190 U and, on the other hand, another metal with an atomic weight ≦90 U. One of the two types of ions are filtered out alternately from the primary ion beam and directed onto the target as a mass-pure primary ion beam. | 09-23-2010 |
20100237235 | DEVICES AND METHODS FOR COUPLING MASS SPECTROMETRY DEVICES WITH CHROMATOGRAPHY SYSTEMS - One embodiment of the invention provides a method of preparing an eluted sample containing salts or buffers from a liquid chromatography device for analysis by a mass spectrometry device. The method includes: continuously providing a non-polar solvent to the mass spectrometry device; receiving the eluted sample from the liquid chromatography device; flowing the eluted sample over a solid phase extraction column; flowing the non-polar solvent over the solid phase extraction column; and presenting non-polar solvent and the eluted sample to the mass spectrometry device. | 09-23-2010 |
20100243881 | HEATED TIME OF FLIGHT SOURCE - A lens assembly for use in mass spectrometry and a method for reducing contaminant build up on ion optic components in a lens assembly for use in a mass spectrometer are disclosed herein. In various embodiments of applicant's teachings, the lens assembly comprises a plurality of ion optic components assembled to form an ion lens and a heater. The plurality of ion optic components has a generally similar expansion coefficient. The heater is operatively coupled to the ion optic components. The heater heats the ion optic components to reduce the accumulation of debris on the ion optic components. In various embodiments, the method includes receiving, in a lens assembly, ions from an ion source. The lens assembly includes a plurality of ion optic components assembled to form an ion lens, the plurality of ion optic components having a generally similar expansion coefficient. The method also comprises heating the ion optic components to a first temperature. | 09-30-2010 |
20100243882 | HEATED OPTICAL COMPONENTS - Applicant's teachings relate to apparatuses and methods of cleaning laser optical components, particularly in, for example, but not limited to, high throughput matrix-assisted laser desorption ionization (MALDI) applications. In accordance with various embodiments of applicant's teachings, the optical component is heated. | 09-30-2010 |
20100243883 | METHOD AND APPARATUS TO PRODUCE STEADY BEAMS OF MOBILITY SELECTED IONS VIA TIME-DEPENDENT ELECTRIC FIELDS - A method is described to select ions based on their electrical mobility. Ions are subjected to at least one full cycle of a time-dependent electric field. Ions are separated in space, and a continuous flow of filtered ions with a narrow range of selected mobility ions is produced at the outlet of the device, as in Differential Mobility Analyzers (DMAs). Yet, no high fluid velocity field is required, avoiding limitations associated in DMAs to flow unsteadiness, compressibility and turbulent transition. Instead, separation relies on the use of time-dependent ion trajectories generated by the time-dependent electric fields. Unlike FAIMS, full separation according to the mobility takes place within one or a few characteristic times for field variation, rather than via many tiny separation steps over many periods of field variation producing separation according to the mobility non-linearities in the mobility. Unlike conventional pulsating ion mobility spectrometry, a steady ion flow is produced with high duty cycle. Different embodiments of the apparatus using the method of the present invention are also described comprising different geometrical configurations and different time-dependent electric profiles, each of them having specific advantages. In a first configuration proposed, a rotary electric field is combined with an axial steady field achieving high resolution and a continuous output throughout all the selected and undesired ions. In a second two-dimensional configuration, an oscillating field is combined with a perpendicular steady field. Much higher sample flow rates can be achieved, though the undesired ions will periodically be transferred. Configurations using more than one stage allow minimizing the undesired pulsed signal of non selected ions. In all those configurations, the trajectories of ions are time dependent and the selected ions are subjected to at least one full cycle of the variable electric field. Separation is based on synchronizing the period of the field with the flight time of an ion from an inlet to an outlet for a particular electrical mobility. | 09-30-2010 |
20100243884 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - A mass spectrometer includes an ionization chamber ( | 09-30-2010 |
20100252727 | EXHAUST SILENCER - The present invention is a method to determine the TAN and TAN as a function of boiling point for a hydrocarbon feedstream using an electrospray ionization mass spectrometer (ESI-MS). The steps of the method include determining the signal as a function of mass from the ESI-MS while minimizing the formation of oligomers and fragmentation of the molecular species in the feedstream and then determining the TAN from the signals. The TAN is also determined as a function of boiling point. | 10-07-2010 |
20100252728 | Mass Spectrometer Using An Accelerating Traveling Wave - A mass spectrogram employs a set of controllable electrodes to produce a time varying axially inhomogenous electric field and enhance separation of charged particles by exposing the charged particles to different electric field strengths based on their spatial positions. The fields may be tailored to provide a traveling wave that expands portions of a spectrographic plot of the particles and/or to provide focusing or other effects. | 10-07-2010 |
20100252729 | METHOD AND APPARATUS FOR DETECTING POSITIVELY CHARGED AND NEGATIVELY CHARGED IONIZED PARTICLES - An ion detector includes collision surfaces for converting both positively and negatively charged ions into emitted secondary electrons. Secondary electrons may be detected using an electron detector, than may, for example include an electron multiplier. Conveniently, secondary electrons (or electrons emitted by the multiplier) may be detected using an electron pulse counter. | 10-07-2010 |
20100264304 | Method for detecting volatile species of high molecular weight - Vapors of relatively heavy species having molecular weights in excess of 290 amu have not been previously detected in the gas phase at ambient temperature. A method to detect them is taught here based on the use of a mass spectrometer with an atmospheric pressure source. Ions produced in detectable quantities from such heavy vapors are claimed as a new state of matter. | 10-21-2010 |
20100264305 | Total Carbon Mass Determination by Accelerator Mass Spectrometry (AMS) Using 13C Isotope Dilution - There is disclosed a method for direct quantitation of total carbon and | 10-21-2010 |
20100264306 | PNEUMATIC ION BEAM FOCUSING IN HIGH-FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY (FAIMS) - A FAIMS device for separating ions has a pair of electrodes for providing a compensation voltage and an asymmetric waveform that are separated and insulated where at least one porous spacer reside in the proximity of the analyzer region of the FAIMS cell. The porous spacers allow a focusing gas to flow into the analyzer region to provide pneumatic focusing of the ions traversing the analyzer region to improve the ion transmission. | 10-21-2010 |
20100270465 | Method and apparatus for thermalization of ions - A method of pulsing gas in a quadrupole ion trap to reduce excess internal energy of ions formed externally to the trap at high-vacuum conditions by laser desoprtion is disclosed. With pulsed gas introduction, pressures greater than those under which traps are normally operated can be achieved over a few milliseconds. Under these elevated pressure transients, the process of translational cooling is accelerated and ions undergo thermalized collisions before dissociation occurs. Minimization of uncontrolled fragmentation (thermalization) and enhanced sensitivity are observed at pressures exceeding a threshold of about 1 mTorr. | 10-28-2010 |
20100270466 | Process for analyzing low molecular weight organic compound having at most 20 carbon atoms in a water/oil repellent compositon - Provided is a process whereby a low molecular weight organic compound having at most 20 carbon atoms present in a trace amount in a water/oil repellent composition can be analyzed accurately. | 10-28-2010 |
20100276582 | MOLECULAR ION ACCELERATOR - A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte. | 11-04-2010 |
20100276583 | Multi-Resolution Scan - A multi-resolution mass spectrometer system and intra-scanning method is introduced to enhance the measured peak resolution at different regions of a given mass spectrum while not significantly increasing the total duration of the scan. Such an arrangement enables extra resolution where necessary, such as, for example, when incorporating a slower scan rate only over a predetermined narrow low mass marker region of a given mass spectrum. Once past the marker region, the scan rate can be increased to provide the appropriate resolution for peptide identification. | 11-04-2010 |
20100276584 | Method and Apparatus for an Ion Transfer Tube and Mass Spectrometer System Using Same - A method for analyzing a sample comprising the steps of: generating ions from the sample within an ionization chamber at substantially atmospheric pressure; entraining the ions in a background gas; transferring the background gas and entrained ions to an evacuated chamber of a mass spectrometer system using an ion transfer tube having an inlet end and an outlet end, wherein a portion of the ion transfer tube adjacent to the outlet end comprises an inner diameter that is greater than an inner diameter of an adjoining portion of the ion transfer tube; and analyzing the ions using a mass analyzer of the mass spectrometer system. | 11-04-2010 |
20100276585 | METHOD FOR DETERMINING THE CONCENTRATION OF A MOLECULE - The present invention relates to a method for determining the concentration of a first molecule having a chemical structure, which contains a first peptide sequence comprising: (a) obtaining a sample containing the first molecule, (b) providing a reference sample which contains a second molecule having a certain concentration and chemical structure, which contains a second peptide sequence, wherein the chemical structure of the second molecule only differs from the structure of the first molecule in one or more permutations in the first peptide sequence, (c) combining the reference sample and the sample containing the first molecule, (d) identifying at least one fragment peak in a mass spectrum (MS) of the first molecule and the second molecule, wherein the mass difference of the fragment peaks is only caused by the permutation of the at least two different amino acids, and (e) determining the concentration of the first molecule relative to the certain concentration of the second molecule by comparing of the identified peaks. | 11-04-2010 |
20100282960 | COMBINED IMAGING AND TRACE-DETECTION INSPECTION SYSTEM AND METHOD - Systems and methods for imaging and chemically identifying contraband are described. In one aspect, a method is provided for locating and identifying contraband on a subject. The method includes scanning the subject using a plurality of imaging sensors to collect radiometric data, collecting chemical data from chemical vapors and particles located on and/or near the subject using a trace-detection sensor, and fusing the collected radiometric data and the collected chemical data to generate at least one of a location of the contraband and a probability of a chemical composition of the contraband. | 11-11-2010 |
20100282961 | Differential mobility spectrometer pre-filter assembly for a mass spectrometer - A pre-filter assembly including a differential mobility spectrometer (DMS) that is configured to be in-line with a mass spectrometer (MS) such that the MS continuously receives carrier flow from the DMS when the DMS filtering fields are removed. | 11-11-2010 |
20100282962 | INTRODUCTION OF ADDITIVES FOR AN IONIZATION INTERFACE AT ATMOSPHERIC PRESSURE AT THE INPUT TO A SPECTROMETER - This invention relates introduction of at least one additive for the analysis of at least one substance of interest using a mass spectrometer or an ion mobility spectrometer. The substance to be analyzed is injected through an API interface. The additive is introduced by adding spray gas. | 11-11-2010 |
20100282963 | Prolonged Ion Resonance Collision Induced Dissociation in a Quadrupole Ion Trap - A technique is disclosed for conducting collision induced dissociation (CID) in a quadrupole ion trap (QIT) having higher order field components. In order to compensate for the shift in the frequency of motion with amplitude of the excited ions arising from the influence of higher-order field components, the amplitude of the RF voltages applied to the QIT is monotonically varied during the excitation period to prolong the condition of resonance, resulting in higher average kinetic energies of the excited ions. Thus, higher fragmentation efficiencies may be obtained, or a targeted level of fragmentation may be achieved in less time relative to conventional CID. | 11-11-2010 |
20100282964 | METHODS AND APPARATUSES TO ALIGN ENERGY BEAM TO ATOM PROBE SPECIMEN - A method for aligning an energy beam to an object in an atom probe is disclosed. The method comprises monitoring at least one parameter indicative of an interaction between the energy beam and the object. A signal is generated in response to the interaction of the energy beam and the object. The signal is then used to effectuate control of the alignment of the energy beam to the object. | 11-11-2010 |
20100282965 | MASS ANALYSIS METHOD AND MASS ANALYSIS SYSTEM - A measurement is performed in a no-passing mode, in which ions having different masses are prevented from making a complete turn through a loop orbit, to obtain a time-of-flight spectrum without the passing of ions having different masses (S | 11-11-2010 |
20100282966 | METHOD AND SYSTEM FOR VACUUM DRIVEN MASS SPECTROMETER INTERFACE WITH ADJUSTABLE RESOLUTION AND SELECTIVITY - A mass spectrometer system and a method of operating same are provided. The system comprises a) an ion conduit for receiving ions; b) a boundary member defining a curtain gas chamber containing the ion conduit; c) a curtain gas supply for providing a curtain gas directed by the boundary member to an inlet of the ion conduit to provide a gas flow into the ion conduit, and a curtain gas outflow out of a curtain gas chamber inlet; d) a mass spectrometer at least partially sealed to, and in fluid communication with, the ion conduit for receiving the ions from the ion conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the ion conduit and into the vacuum chamber; and, e) a gas outlet for drawing a gas outflow from the gas flow located between the ion conduit and the mass spectrometer to increase the gas flow rate through the ion conduit. | 11-11-2010 |
20100288917 | System and method for analyzing contents of sample based on quality of mass spectra - A method of performing tandem mass spectrometry (MS/MS) for identifying contents of a sample includes performing a mass spectrometry (MS) scan of the sample to obtain an MS/MS mass spectrum; identifying a first precursor ion species in the MS mass spectrum; performing an initial MS/MS scan of the first precursor ion species to obtain an initial MS/MS mass spectrum; and determining whether the initial MS/MS mass spectrum has a quality acceptable for peptide sequencing. When the first MS/MS mass spectrum has an unacceptable quality, the method further includes performing a subsequent MS/MS scan of the first precursor ion species to obtain a corresponding subsequent MS/MS mass spectrum of the first precursor ion species, and determining whether the subsequent MS/MS mass spectrum has a quality acceptable for peptide sequencing. | 11-18-2010 |
20100288918 | System and method for performing tandem mass spectrometry analysis - A system for performing tandem mass spectrometry (MS/MS) analysis of a sample includes a mass spectrometer and a processor. The mass spectrometer is configured to perform a mass spectrometry (MS) scan of an ionized sample to provide a mass of an observed peak corresponding to a precursor ion. The processor is configured to perform operations including determining whether the mass of the observed peak matches a mass of at least one of multiple expected peptides on a dynamic watch list, where the expected peptides correspond to a protein in the sample, and calculating a score of an accuracy of the determination when the mass of the observed peak is determined to match the mass of at least one of the plurality of expected peptides. The precursor ion is excluded from an MS/MS scan when the accuracy score indicates that the determination is accurate. | 11-18-2010 |
20100288919 | Radio Frequency lens for introducing ions into a quadrupole mass analyzer - An improved ion optical lens designed to increase the amount of ion current delivered into a multi-pole ion detector or transfer device, such as quadrupole mass analyzer, an ion guide, collision cell, etc. A device and method is disclosed that utilizes a tubular entrance lens to introduce ions into or sample ions at a field-free or near field-free region disposed at the junction of two sets of multi-pole assemblies operating with radio frequency potentials shifted 180 degrees out of phase with respect to each other. The method is useful for increasing the transport of ions into as they enter into or exit out of a multi-pole mass analyzer, such as a quadrupole mass analyzer, an ion guide, collision cell, etc. | 11-18-2010 |
20100288920 | METHOD AND APPARATUS FOR ION FRAGMENTATION IN MASS SPECTROMETRY - A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions. | 11-18-2010 |
20100294923 | MASS SPECTROMETER - A collision or fragmentation cell ( | 11-25-2010 |
20100294924 | ION SPECTRUM ANALYSING APPARATUS AND METHOD - An ion spectrum analysing apparatus ( | 11-25-2010 |
20100294925 | SAMPLING OF CONFINED SPACES - In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container. | 11-25-2010 |
20100294926 | MASS SPECTROMETRY APPARATUS AND METHOD USING THE APPARATUS - A mass-spectrometry apparatus includes a substrate for mass spectrometry used in surface-assisted laser desorption/ionization mass spectrometry, a light irradiation means that irradiates sample S in contact with a surface of the substrate with measurement light L | 11-25-2010 |
20100301199 | Ultrasound ionization mass spectrometer - Methods and systems for ultrasound ionization mass spectrometry are provided. Analytes in a sample are ionized by subjecting them to ultrasound, facilitating their analysis by mass spectrometry. With these methods and systems, soft ionization of large analytes, including biological macromolecules and nanoparticles, can be achieved. Ionization efficiency can be improved by addition of chemicals such as, for example, organic solvents or acids to the sample. | 12-02-2010 |
20100301200 | Mass Spectrometer - An ion source, a mass spectrometer and a method of enhancing the performance of an ion source for use with a mass spectrometer. The ion source has a housing incorporating an ion source enclosure defining a chamber and an outer cover remote from the chamber. A fluid flow passageway is provided between the ion source enclosure and the outer cover. The method of the invention comprising supplying to the ion source housing a regulated flow of fluid through the fluid passageways so as to maintain the ion source enclosure within a predetermined temperature range of substantially between 60° c. and 80° c. and preferably at 70° c. | 12-02-2010 |
20100301201 | Mass Spectrometer And Method Of Mass Spectrometry - The invention relates to a method of derivina improved data from a mass spectrometer. The method includes operating the mass spectrometer in a mode enabling quantitation; assigning a threshold value for the total ion current (TIC) above which at least MS and/or MSMS data is desired; and triggering the mass spectrometer out of the mode enabling quantitation into at least an MS and/or MSMS mode when said TIC rises above the threshold but triggering only at such time at or after a confirmed TIC maxima has been reached. | 12-02-2010 |
20100301202 | Tandem TOF Mass Spectrometer With High Resolution Precursor Selection And Multiplexed MS-MS - A tandem TOF mass spectrometer includes a first TOF mass analyzer that generates an ion beam comprising a plurality of ions and that selects a group of precursor ions from the plurality of ions. A pulsed ion accelerator accelerates and refocuses the selected group of precursor ions. An ion fragmentation chamber is positioned to receive the selected group of precursor ions that is refocused by the pulsed ion accelerator. At least some of the selected group of precursor ions is fragmented in the ion fragmentation chamber. A second TOF mass analyzer receives the selected group of precursor ions and ion fragments thereof from the ion fragmentation chamber and separates the ion fragments and then detects a fragment ion mass spectrum. | 12-02-2010 |
20100301203 | METHOD OF DIAGNOSTIC HEPARIC DISEASE BY SUGAR CHAIN ANALYSIS - It is intended to provide a novel diagnosis method for a hepatic disease, in particular, HCC. A serum sugar chain usable as a novel biomarker is provided by analyzing the relationship between the quantitative expression profiles of sugar chains in the serum and individual disease conditions and thus finding a sugar chain showing a change with the progression of a hepatic disease. | 12-02-2010 |
20100308216 | FAIMS Ion Mobility Spectrometer With Multiple Doping - A FAIMS ion mobility spectrometer is arranged so that the analyte is subject to different ion chemistries at different locations along the spectrometer. Different dopants, or different concentrations of dopants or water vapor are admitted at various locations, such as at the inlet, between the inlet and the ionizer between the ionizer and the gate, between the gate and the FAIMS parallel plates, through an opening in one of the plates, or between the end of the plates and the detector. | 12-09-2010 |
20100308217 | Method and system for internal chemical ionization with water in ion mass spectrometry - Method and system that allows the use of water as reactant gas for internal chemical ionization in mass spectrometry. The system provides a stable water vapor pressure in the ion trap by condensation-free water vapor flow between water reservoir and ion trap. The system can be implemented by modification of any type of ion-trap mass spectrometer designed for internal chemical ionization. | 12-09-2010 |
20100314537 | METHOD AND APPARATUS FOR ACTIVATION OF CATION TRANSMISSION MODE ION/ION REACTIONS - A method and apparatus for radial activation of transmission-mode electron transfer ion/ion reactions using a dipolar AC field applied transverse to a transit direction is disclosed. Increases in fragment ion yields and structural information from electron transfer dissociation (ETD) were observed. The method may be used for transmission mode ETD for relatively low charge states of peptides and proteins. | 12-16-2010 |
20100320372 | MOLECULE MASS DETECTION VIA FIELD EMISSION OF ELECTRONS FROM MEMBRANES - An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semiconductor membrane having an external surface that is contacted by one or more molecules, and an internal surface having a thin metallic layer or other type of electron emitting layer. The kinetic energy of molecules contacting the semiconductor membrane is transferred through the membrane and induces the emission of electrons from the emitting layer. An electron detector, which optionally includes means for electron amplification, is positioned to detect the emitted electrons. | 12-23-2010 |
20100320373 | MASS SPECTROMETRIC QUANTITATIVE DETECTION OF METHYL MALONIC ACID AND SUCCINIC ACID USING HILIC ON A ZWITTERIONIC STATIONARY PHASE - The invention provides a method for qualitatively and quantitatively detecting methyl malonic acid in a clinical sample that also may contain succinic acid and homocysteine, said method involving a liquid chromatography separation step followed by a mass spectroscopy detection step, said method comprising the steps of:
| 12-23-2010 |
20100320374 | DEVICES AND METHODS FOR PERFORMING MASS ANALYSIS - Embodiments of the present invention feature devices and methods for performing mass analysis. One embodiment of the device comprises an inlet housing for mounting on the first wall between the area of low pressure and the area of high pressure. The inlet housing has passages and restrictions which can be adjusted with respect to a sample plume or changed by substituting alternative inlet housings. | 12-23-2010 |
20100320375 | MEASUREMENT OF ION MOBILITY SPECTRA WITH ANALOG MODULATION - A method is provided for measuring mobility spectrum of ions in an ion mobility spectrometer having an ion source, a modulator, an ion drift region and an ion detector disposed at the end of the ion drift region. The method includes the steps of modulating an ion current from the ion source, and measuring the mobility spectrum, where a predistortion of the continuous modulation function substantially compensates for a distortion created by the modulator. The ion current is modulated with the modulator by varying an instantaneous frequency of a continuous modulation function across a frequency range. The mobility spectrum is measured by correlating the ion current measured at the detector and the modulation function. | 12-23-2010 |
20100327155 | Micro-plasma Illumination Device and Method - An illumination method and device has a micro-wave powered plasma source contained by a windowless plasma containment structure. When incorporated as a photo-ionization device in an ion mobility spectrometer (IMS), the resolution of the spectrometer may be improved by operation at higher pressures and through selective ionization of elements and compounds. A gas flows into a discharge gap of a micro-wave ring resonator, but is restricted from flowing away by the windowless containment structure. When microwave power is supplied, the discharge gap is energized and a plasma initiated and sustained. Photons emitted by the plasma photo-ionize a sample gas. As the containment structure is windowless, the wavelength of the emitted radiation depends on the plasma-forming gas, not on the transmission characteristics of a window material. The range of substances in the sample that are ionized may be influenced by selecting the plasma-forming gas. | 12-30-2010 |
20100327156 | Self-Aligning Floating Ion-Optics Components - A mass spectrometry system includes an ion-optics and a housing for the ion-optics. A panel is movable between an open and closed position relative to the housing. A first section of the ion-optics is within the housing, while a second section of the ion-optics is mounted to the panel. The ion-optics is surrounded by the housing and the panel when the panel is in the closed position. An alignment mechanism aligns the first and second sections of the ion-optics into a pre-determined alignment upon closing the panel. | 12-30-2010 |
20100327157 | Mass Spectrometer - A mass spectrometer is disclosed comprising a time of flight mass analyser ( | 12-30-2010 |
20100327158 | Vibrating Probe - A measuring system comprising: a MIMS probe | 12-30-2010 |
20110001041 | METHOD AND APPARATUS ALLOWING QUANTITATIVE INVESTIGATIONS OF ORGANIC AND INORGANIC SAMPLE BY DECOUPLING THE SPUTTERING PROCESS FROM THE ANALYSIS PROCESS - A method and an analytical instrument are for quantitative investigations of organic and inorganic samples using the Secondary Ion Mass Spectromy (SIMS) technique. The sputtering process is decoupled from the analysis process. | 01-06-2011 |
20110001042 | ASSESSING TREATMENT COMPLIANCE - This document provides methods and materials related to determining whether or not a mammal is receiving a steroid treatment. For example, methods and materials involved in assessing a biological sample (e.g., a urine sample) from a mammal for the presence or absence of a steroid or a steroid metabolite to determine whether or not the mammal is complying with a steroid treatment (e.g., a corticosteroid treatment for an allergic disease or asthma) are provided. | 01-06-2011 |
20110001043 | DETECTOR DEVICE FOR HIGH MASS ION DETECTION, A METHOD FOR ANALYZING IONS OF HIGH MASS AND A DEVICE FOR SELECTION BETWEEN ION DETECTORS - Described here is a detector for measuring heavy mass ions with high sensitivity and low saturation for time-of-flight mass spectrometry and a detector housing for selecting between multiple detectors. It relates to sensitive measuring methods of large masses in the range of about ten thousand to a few million atomic mass units. Specifically it relates to a conversion dynode in a specifically insolated geometry followed by a discrete dynode secondary electron multiplier specifically modified to decrease electron saturation and electronic ringing. Conversion dynode detectors have been used before for time-of-flight mass spectrometry and compared to direct detection with electron multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions. Using a conversion dynode specifically insolated to a common ground plane has the added capabilities of allowing an increased voltage to be applied to the conversion dynode while maintaining a minimum distance between the conversion dynode and the front of the electron multiplier. This creates faster ion flight time for the secondary ions produced within the detector allowing for higher time resolution and sensitivity from the detector. Also, by adding capacitance as charge buffers to the last few electrodes of a discrete dynode electron multiplier used as a secondary electron multiplier, saturation can be greatly reduced or avoided, which is often a major problem when measuring samples with ions covering a broad mass range. The detector housing described allows multiple detectors to be selected without breaking the vacuum. By keeping all moving mechanical parts inside the vacuum, a more simple, robust and cost effective design can be realized which provides a platform for measuring ions using different detector designs. | 01-06-2011 |
20110001044 | INTEGRATED ION SEPARATION SPECTROMETER - An apparatus including an ion injector having an inlet and an outlet and a micro-corona ionizer positioned between the inlet and the outlet of the ion injector. A drift and separation channel having a first end and a second end is positioned with the first end coupled to outlet of the ion injector, and an ion detector is coupled to the second end of the ion separation and drift channel. Other embodiments are disclosed and claimed. | 01-06-2011 |
20110006197 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 01-13-2011 |
20110006198 | ATMOSPHERIC PRESSURE ION SOURCE PERFORMANCE ENHANCEMENT - Electrospray ionization sources interfaced to mass spectrometers have become widely used tools in analytical applications Processes occurring in Electrospray (ES) ionization generally include the addition or removal of a charged species such as II+ or other cation to effect ionization of a sample species. Electrospray includes ionization processes that occur in the liquid and gas phase and in both phases ionization processes require a source or sink for such charged species. Electrolyte species, that aid in oxidation or reduction reactions occurring in Electrospray ionization, are added to sample solutions in many analytical applications to increase the ES ion signal amplitude detected by a mass spectrometer (MS). Electrolyte species that may be required to enhance an upstream sample preparation or separation process may be less compatible with the downstream ES processes and cause reduction in MS signal. A new set of Electrolytes has been found that increases positive and negative polarity analyte ion signal measured in ESMS analysis when compared with analyte ESMS signal achieved using more conventional electrolytes. The new electrolyte species increase ES MS signal when added directly to a sample solution or when added to a second solution flow in an Electrospray membrane probe. The new electrolytes can also be added to a reagent ion source configured in a combination Atmospheric pressure ion source to improve ionization efficiency. | 01-13-2011 |
20110006199 | METHOD FOR MEASURING GASES AND CORRESPONDING ION MOBILITY SPECTROMETER - The invention relates to a method and device for measuring gaseous substances, in which the method comprises the stages:
| 01-13-2011 |
20110012016 | SPECTROPHOTOMETRIC IDENTIFICATION OF MICROBE SUBSPECIES - A dual-stage method is provided for identifying a microbe by, for example, its species or its subspecies. The method includes measuring a mass spectrum of the microbe using a mass spectrometer, calculating indicators for similarities between reference mass spectra in a library and the measured mass spectrum, selecting a group of reference mass spectra similar to the measured mass spectrum, determining a distinguishing weight for each mass signal of the reference mass spectra in the group, where the distinguishing weights emphasize differences between the reference mass spectra in the group, and calculating indicators for similarities between the reference mass spectra in the group and the measured mass spectrum as a function of the distinguishing weights. | 01-20-2011 |
20110017907 | Multireflection Time-Of-Flight Mass Spectrometer - The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof. | 01-27-2011 |
20110024614 | SIFT-MS INSTRUMENT - A method of improving signal intensity of precursor ions constrained in a carrier gas in the flow tube of a SIFT-MS instrument, and an apparatus to carry out the method. The method applies an electrical potential to the flow tube to lower the diffusive loss of ions within the flow tube. The lowered diffusive loss of ions increases the sensitivity of the technique. | 02-03-2011 |
20110024615 | CELL INJECTOR FOR FLOW CYTOMETER HAVING MASS SPECTROMETER DETECTOR AND METHOD FOR USING SAME - A flow cytometer instrument and method for use thereof is described. The cell injector can receive particles from a sample slurry of particles associated with a biological material, and the cell injector can select particles from the sample slurry for injection into a mass spectrometer detector for the analysis of the individual particle. The spectrometer can have a plasma torch having a center tube being connected to the cell injector to receive the particles, a radio frequency power source and a load coil coupled to the plasma torch to generate and maintain a plasma in the plasma torch for ionizing the received particles, and a mass detector disposed downstream of the plasma torch for receiving ionized particles from the plasma torch and operative for detecting the particles in the sample slurry. | 02-03-2011 |
20110024616 | Gas Electron Multiplier Detector - A mass spectrometer is disclosed comprising a Gas Electron Multiplier ion detector. The ion detector comprises three gas electron multiplier stages GEM | 02-03-2011 |
20110024617 | SWITCHED FERROELECTRIC PLASMA IONIZER - A novel ion source for ambient mass spectrometry (switched ferroelectric plasma ionizer or “SwiFerr”), which utilizes the ambient pressure plasma resulting from a sample of barium titanate [001] whose polarization is switched by an audio frequency electric field. High yields of both anions and cations are produced by the source and detected using an ion trap mass spectrometer. Protonated amines and deprotonated volatile acid species, respectively, are detected in the observed mass spectra. Aerodynamic sampling is employed to analyze powders of drug tablets of loperamide and ibuprofen. A peak corresponding to the active pharmaceutical ingredient for each drug is observed in the mass spectra. Pyridine is detected at concentrations in the low part-per-million range in air. The low power consumption of the source is consistent with incorporation into field portable instrumentation for detection of hazardous materials and trace substances in a variety of different applications. | 02-03-2011 |
20110031389 | System and Method for Trapping and Measuring a Charged Particle in a Liquid - A system and method for trapping a charged particle is disclosed. A time-varying periodic multipole electric potential is generated in a trapping volume. A charged particle under the influence of the multipole electric field is confined to the trapping volume. A three electrode configuration giving rise to a 3D Paul trap and a four planar electrode configuration giving rise to a 2D Paul trap are disclosed. | 02-10-2011 |
20110031390 | METHOD OF MANUFACTURING AN ANALYTICAL SAMPLE AND METHOD OF ANALYZING AN ANALYTICAL SAMPLE - A method of manufacturing an analytical sample by a secondary ion mass spectrometry method is provided, which comprises a step of forming a separation layer over a substrate, a step of forming one of a thin film and a thin-film stack body to be analyzed over the separation layer, a step of forming an opening portion in one of the thin film and the thin-film stack body, a step of attaching a supporting body to one of a surface of the thin film and a surface of a top layer of the thin-film stack body, and a step of separating one of the thin film and the thin-film stack body from the substrate. | 02-10-2011 |
20110031391 | METHOD FOR GENERATION AND USE OF ISOTOPIC PATTERNS IN MASS SPECTRAL DATA OF SIMPLE ORGANISMS - A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent. | 02-10-2011 |
20110036973 | ION PUMP - The invention provides an ion pump to be used for selectively transferring ionised molecules across a barrier from a first volume to a second volume. The pump comprises an ion gate or filter separating the two volumes, the filter comprising at least one ion channel extending between the first and second spaces, the channel defined by a plurality of conductive layers separated along the length of the channel by at least one non-conductive layer; the device further comprising control means for applying an electric potential to the conductive layers such that the conductive layers act as electrodes. Other aspects of the invention relate to methods for selectively transferring ions. | 02-17-2011 |
20110036974 | GUIDING SPRAY DROPLETS INTO AN INLET CAPILLARY OF A MASS SPECTROMETER - Charged droplets are guided along a defined path from a droplet source to a droplet sink. A focusing pseudopotential distribution generated by audio frequencies on electrodes of a guiding device guide the charged droplets from the droplet source to the droplet sink with low loss. The droplets can be driven along the droplet guide by a gas flow, an axial electric field or a combination of both. For example, charged droplets from a spray capillary of an electrospray ion source at atmospheric pressure may be introduced into the inlet capillary leading to the vacuum system of ion analyzers, a procedure similar to that used up to now in nanoelectrospraying, but with substantially higher flow rates. In the guiding device, the droplets can be manipulated in different ways, for example evaporated down to a desired size. The introduction of small droplets into gas-aspirating capillaries is of interest because it is possible to keep the droplets on axis by Bernoulli focusing and to guide them in large quantities and with low loss through the capillary. The ability to guide the droplets makes it also possible to install a segmented inlet capillary with intermediate pumping, which allows pumping capacity to be saved. Advantageously, the sensitivity of ion analyzers such as mass spectrometers or ion mobility spectrometers by at least one order of magnitude. | 02-17-2011 |
20110036975 | IMIDAZOLIUM-BASED LIQUID SALTS AND METHODS OF USE THEREOF - Imidazolium-based dicationic liquid salts and methods of using such imidazolium-based dicationic liquid salts in techniques such as ESI-MS are provided. | 02-17-2011 |
20110036976 | Atmospheric Pressure Ionization Mass Spectrometer - The present invention aims at suppressing noises when a mass analysis is performed by introducing a sample solution into an atmospheric pressure ion source by a pressurized liquid feeding method. As a dilution solvent of the sample solution contained in a sample container, a mixed liquid is used in which the mixture ratio of an organic solvent such as methanol is decreased to 20% and the ratio of water is 80%. Since nitrogen, which is a gas for the pressurization, is soluble in an organic solvent, decreasing the ratio of the organic solvent lowers the saturated dissolution amount and suppresses unstable emergence of the gas in the process of the mass analysis. Consequently, even after the elapse of a considerable length of time from the start of liquid feeding, spike-like noises do not appear in the ion intensity, which stabilizes the ion intensity. | 02-17-2011 |
20110042559 | SUBSTANCE IDENTIFICATION USING A SERIES OF ION MOBILITY SPECTRA - A method for identifying an analyte includes introducing a transient cloud with an increasing and a decreasing analyte concentration into an ion mobility spectrometer, determining a series of analyte spectra, and identifying the analyte using mobility values and process kinetics from a formation of different types of analyte ions which is visible in a signal profile of the series of analyte spectra. | 02-24-2011 |
20110042560 | LOW TEMPERATURE PLASMA PROBE AND METHODS OF USE THEREOF - The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow. | 02-24-2011 |
20110042561 | METHODS AND APPARATUS FOR ENHANCED ION BASED SAMPLE DETECTION USING SELECTIVE PRE-SEPARATION AND AMPLIFICATON - The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification. | 02-24-2011 |
20110049346 | METHODS AND APPARATUS FOR FILLING AN ION DETECTOR CELL - In a mass spectrometer, a dual stage axial extraction field is applied to transport ions from an accumulator with a shutter and an ion guide to a detector cell. Ions of the same mass may be transported to the detector cell or a point axially preceding the detector cell at the same time by selecting the relative strengths of a first axial electric field applied to the accumulator and a second axial electric field applied to the shutter and further by selecting relative axial lengths of the accumulator, shutter, and an ion guide. A dual stage decelerating field may also be applied to slow ion down prior to and after entering the detector cell. | 03-03-2011 |
20110049347 | ELECTRON CAPTURE DISSOCIATION APPARATUS AND RELATED METHODS - An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along the central axis. The electron emitter is disposed outside the interior space. The electron control device is configured for focusing an electron beam from the electron emitter toward the central axis, along a radial electron beam direction between two of the ion guide electrodes, and for decelerating the electron beam in a DC decelerating field of adjustable voltage potential directed along the electron beam direction. | 03-03-2011 |
20110049348 | MULTIPLE INLET ATMOSPHERIC PRESSURE IONIZATION APPARATUS AND RELATED METHODS - An atmospheric pressure ionization apparatus with a plurality of sprayers configured for producing separate gas streams comprising charged material, an interface structure, and a capillary. The interface structure includes a plurality of entrance orifices aligned on-axis or off-axis with respective sprayers, a plurality of desolvating passages extending from the entrance orifices to respective passage outlets, and a common passage communicating with the passage outlets. The desolvating passages form a plurality of input flow paths running from the entrance orifices and merging into the common passage. The capillary communicates with the common passage and extends therefrom to a capillary outlet positioned outside the interface structure, wherein the capillary forms a single output flow path running from the merged input flow paths to the capillary outlet. Desolvated ions from the first and second passages may be flowed together through the capillary as a mixture, or may be flowed sequentially. | 03-03-2011 |
20110049349 | PRECISION PEAK MATCHING IN LIQUID CHROMATOGRAPHY-MASS SPECTROSCOPY - A method that identifies common peaks among unidentified peaks in the data from different LC-MS or LC-MS/MS runs is provided. The method employs an algorithm, herein referred to as “Precision Peak Matching (PPM).” The different runs can be from different laboratories, instruments, and biological samples that result in a significant variability in the data. PPM allows estimation and control of precision, defined as the fraction of truly identical peptide pairs among all pairs retrieved, in the matching process. PPM finds the maximal number of peptide pairs at a prescribed precision, thereby allowing quantitative control over the trade off between the number of true pairs missed, and false pairs found. PPM finds common peptides from a database of LC-MS runs of heterogeneous origins, and at the specified precision. PPM fills a much-needed role in proteomics by extracting useful information from disparate LC-MS databases in a statistically rigorous and interpretable manner. | 03-03-2011 |
20110049350 | Tandem TOF Mass Spectrometer With Pulsed Accelerator To Reduce Velocity Spread - A tandem TOF mass spectrometer includes a pulsed ion source that generates a pulse of precursor ions from a sample to be analyzed. A first pulsed ion accelerator accelerates and refocuses a predetermined group of precursor ions. A first timed ion passes the predetermined group of precursor ions and rejects substantially all other ions. An ion fragmentation chamber fragments at least some of the precursor ions in the predetermined group. A second timed ion selector selects a predetermined range of masses centered on each precursor in the predetermined group and rejects substantially all other ions. A second pulsed ion accelerator accelerates and refocuses the selected precursor ions and fragments thereof. An ion mirror generates a reflected ion beam. An ion detector detects precursor ions and fragments, wherein a flight time from the second pulsed ion accelerator to the ion detector is dependent on a mass-to-charge ratio of the selected precursor ions and fragments thereof and nearly independent of an initial velocity distribution of ions in the pulse of ions. | 03-03-2011 |
20110049351 | Methods for Acquisition and Deductive Analysis of Mixed Fragment Peptide Mass Spectra - A method for acquiring and analyzing polypeptide mass spectra comprising: creating first and second sets of fragmented ions using first and second fragmentation techniques; obtaining mass spectra of the first and second sets of fragmented ions; searching a database of fragments of a first fragment pair type and of a second fragment pair type to respectively provide a set of M ranked and a set of N ranked best matching polypeptide sequences; subtracting synthetic spectra corresponding to each of the M and N ranked sequences from the mass spectra to provide first and second sets of modified mass spectra; searching the database of fragments of the second fragment pair type and of the first fragment pair type to provide third and fourth sets of polypeptide sequences providing best matches to the first and second sets of modified spectra, respectively; and creating a cumulative ranking of the third and fourth sets. | 03-03-2011 |
20110049352 | ION SOURCE - This invention relates to a desorpton/ionization source operated under ambient conditions for direct analysis of solid or liquid samples on a surface. The source comprises of a laser desorption system and a UV/electrospray combined ionization system. The source is suitable for simultaneously ionizing samples with different polarity in a complex mixture. At the same time, the compact design of the source with multiple channels can maintain the level of local concentration of the analyte ions inside the source for higher efficiency of sample ionization and introduction. | 03-03-2011 |
20110049353 | Mass Spectrometer - A mass spectrometer is disclosed wherein a signal output from an ion detector is digitised using an Analogue to Digital Converter. A background or baseline level is dynamically subtracted from the digitised signal whilst the time of flight data is still being acquired. A threshold is also applied dynamically to the digitised signal in order to reduce electronic noise. | 03-03-2011 |
20110049354 | METHOD AND DEVICE FOR DETECTING AT LEAST ONE TARGET SUBSTANCE - Method for detecting at least one target substance, including converting molecules of at least one of the target substances to a gaseous state and a spectrometric detection of the molecules. The object is to significantly increase the resolving capacity of the method in its detection limit and in its selectivity. This is achieved in that the conversion includes soluble mixing, formation of aerosol and evaporation of at least one of the target substances with a solvent, the molecules being integrated into a gas phase, and the spectrometric detection includes an ionisation of the molecules in the gas phase to form ions. | 03-03-2011 |
20110049355 | FAST TIME-OF-FLIGHT MASS SPECTROMETER WITH IMPROVED DATA ACQUISITION SYSTEM - Time-of-flight mass spectrometer instruments are disclosed for monitoring fast processes with large dynamic range using a multi-threshold TDC data acquisition method or a threshold ADC data acquisition method. Embodiments using a combination of both methods are also disclosed. | 03-03-2011 |
20110057095 | METHOD, SYSTEM AND APPARATUS FOR FILTERING IONS IN A MASS SPECTROMETER - A method and mass spectrometer for filtering ions are provided. The mass spectrometer generally comprises an ion guide, a quadrupole mass filter, a collision cell and a time of flight (ToF) detector, and is enabled to transmit an ion beam through to the ToF detector. The mass spectrometer is operated in MS mode, such that ions in the ion beam remain substantially unfragmented, the quadrupole mass filter operating at a pressure substantially lower than in either of the ion guide and the collision cell. The quadrupole mass filter is operated in a bandpass mode such that ions outside of a range of interest are filtered from the ion beam, leaving ions inside the range of interest in the ion beam. The ions inside the range of interest are analyzed at the ToF detector. | 03-10-2011 |
20110057096 | METHOD AND APPARATUS TO ACCURATELY DISCRIMINATE GAS PHASE IONS WITH SEVERAL FILTERING DEVICES IN TANDEM - A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list. | 03-10-2011 |
20110062320 | Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry - The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra. | 03-17-2011 |
20110062321 | MULTI-PHOTON IONIZATION SPECTROMETER - A method of assaying a solid or liquid material, the method comprising: illuminating a sample of the material with pulses of light at a plurality of different wavelengths at which atoms and/or molecules in the material are ionized in multiphoton ionization (MPI) process; generating a value responsive to charge produced in the ionization process for each wavelength to provide an MPI spectrum for the material; and processing the MPI spectrum to assay an atom or molecule in the material. | 03-17-2011 |
20110062322 | HIGH-RESOLUTION ION MOBILITY SPECTROMETRY - A supersonic gas jet having gas molecules with substantially equal velocities is formed by directing the gas through a Laval nozzle into an evacuated chamber. A field barrier having a substantially constant height across a cross-section of the supersonic gas jet is formed by respectively applying potentials U | 03-17-2011 |
20110062323 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 03-17-2011 |
20110068262 | SYSTEMS AND METHODS FOR DETERMINING RECYCLED THERMOPLASTIC CONTENT - A system and method of identifying a reference standard library for thermoplastic content includes preparing a plurality of samples of each one of a plurality of known ratios of virgin thermoplastic/recycled thermoplastic, analyzing each of the plurality of samples of each one of the plurality of known ratios of virgin thermoplastic/recycled thermoplastic with at least one of a group of analyses consisting of: a differential scanning calorimetry analysis; a physical thickness analysis; an ultraviolet-visible spectroscopy analysis; an attenuated total reflectance Fourier transform infrared spectroscopy analysis; a mechanical analysis; or a plasma atomic emission spectroscopic analysis. The method is also comprised of selecting a contaminant, identifying a first plurality of indicators output from the at least one of the group of analyses, identifying a second plurality of indicators from the first plurality of indicators, the second plurality of indicators being independent of the selected contaminant and optimizing the second plurality of indicators to identify a third plurality of indicators, the third plurality of indicators being quantitatively different of the selected contaminant wherein each one of the third plurality of indicators has at least one corresponding value for each one of the plurality of known ratios of virgin thermoplastic/recycled thermoplastic. Systems and methods for determining content of recycled thermoplastic in a thermoplastic sample are also disclosed. | 03-24-2011 |
20110068263 | System for Preventing Backflow in an Ion Source - A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance. | 03-24-2011 |
20110073754 | HIGH PRECISION ELECTRIC GATE FOR TIME-OF-FLIGHT ION MASS SPECTROMETERS - A time-of-flight mass spectrometer having a chamber with electrodes to generate an electric field in the chamber and electric gating for allowing ions with a predetermined mass and velocity into the electric field. The design uses a row of very thin parallel aligned wires that are pulsed in sequence so the ion can pass through the gap of two parallel plates, which are biased to prevent passage of the ion. This design by itself can provide a high mass resolution capability and a very precise start pulse for an ion mass spectrometer. Furthermore, the ion will only pass through the chamber if it is within a wire diameter of the first wire when it is pulsed and has the right speed so it is near all other wires when they are pulsed. | 03-31-2011 |
20110073755 | Selective molecular excitation method and isotope separation method using the same, isotope analysis method, selective molecular excitation apparatus and isotope separation apparatus - Molecules of a specific species can be selectively excited among molecules of a plurality of species that show only a slight difference of mass. Energy levels can be displayed on a graph where the horizontal axis indicates excitation energy. Assume an instance where an electromagnetic wave showing a comb-shaped spectrum having a plurality of narrow bands as indicated by P | 03-31-2011 |
20110084203 | METHOD AND APPARATUS FOR PYROLYSIS-INDUCED CLEAVAGE IN PEPTIDES AND PROTEINS - A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed. | 04-14-2011 |
20110084204 | METHOD FOR GENERATION AND USE OF ISOTOPIC PATTERNS IN MASS SPECTRAL DATA OF SIMPLE ORGANISMS - A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent. | 04-14-2011 |
20110084205 | Collision Cell - A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. | 04-14-2011 |
20110089318 | APPARATUS SYSTEM AND METHOD FOR MASS ANALYSIS OF A SAMPLE - A mass spectrometer comprised of a mass analyzer, ion source and detector has the capability of analyzing samples in both positive and negative ionization modes. The mass spectrometer used in conjunction with a liquid chromatograph, fluid splitters and a plurality fluid pathways so that a large volume of analyses may be performed quickly and with high precision and accuracy. The apparatus is also capable of analyzing complex mixtures such as coeluting samples. | 04-21-2011 |
20110089319 | NANO-ELECTROSPRAY IONIZATION TECHNIQUE AND DEVICE - Nano-electrospray ionization techniques include the introduction of a separation solvent containing a sample to a column-integrated needle having a column filled with a resin for liquid chromatography. The separated sample components are sprayed from the tip of the column-integrated needle toward a sample introduction orifice of a mass spectrometer. An organic solvent is simultaneously introduced to a solvent-supplying needle. The organic solvent is supplied from the tip of the solvent-supplying needle to the tip of the column-integrated needle. | 04-21-2011 |
20110095175 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes ( | 04-28-2011 |
20110095176 | Mass Spectrometer - A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound. | 04-28-2011 |
20110095177 | Detection Apparatus for Detecting Charged Particles, Methods for Detecting Charged Particles and Mass Spectrometer - Embodiments of the invention provide a detection apparatus for detecting charged particles having a secondary particle generator for generating secondary charged particles in response to receiving incoming charged particles, a charged particle detector for receiving and detecting secondary charged particles generated by the secondary particle generator, a photon generator for generating photons in response to receiving secondary charged particles generated by the secondary particle generator, and a photon detector for detecting the photons generated by the photon generator. | 04-28-2011 |
20110095178 | Detection Apparatus for Detecting Charged Particles, Methods for Detecting Charged Particles and Mass Spectrometer - Embodiments of the invention provide a detection apparatus for detecting charged particles having a charged particle detector for receiving and detecting either incoming charged particles or secondary charged particles generated from the incoming charged particles, a photon generator for generating photons in response to receiving at least some of the same incoming charged particles or secondary charged particles generated from the incoming charged particles as are received and detected by the charged particle detector, and a photon detector for detecting photons generated by the photon generator. | 04-28-2011 |
20110095179 | Disease Diagnosis Method, Marker Screening Method and Marker Using TOF-SIMS - The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/s) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks. | 04-28-2011 |
20110101213 | METHOD AND SYSTEM FOR INCREASING BEAM CURRENT ABOVE A MAXIMUM ENERGY FOR A CHARGE STATE - Methods and a system of an ion implantation system are disclosed that are capable of increasing beam current above a maximum kinetic energy of a first charge state from an ion source without changing the charge state at the ion source. Positive ions having a first positive charge state are selected into an accelerator. The positive ions of the first positive charge state are accelerated in acceleration stages and stripped to convert them to positive ions of a second charge state. A second kinetic energy level higher than the maximum kinetic energy level of the first charge state can be obtained. | 05-05-2011 |
20110101214 | COUPLING DIFFERENTIAL MOBILITY BASED AMBIENT PRESSURE ION PREFILTERING AND ION FOCUSING AT LOW FLOW RATES FOR A PORTABLE MASS SPECTROMETER - A sample analysis apparatus and system including an ion inlet, an ion detector and an ion focusing assembly for converging a plurality of ion streams from the ion inlet into at least one focused ion stream. | 05-05-2011 |
20110101215 | QUANTITATIVE ANALYSIS METHOD USING MASS SPECTROMETER - In quantitation without using the isotope labeling technique, there is no means to detect the presence/absence and the time region of the occurrence of quantitative analysis-inhibitory factors in data for the analysis, and the reliability of the data for the analysis cannot be evaluated. Also, the error of the data due to the occurrence of the quantitative analysis-inhibitory factors cannot be evaluated. In order to solve the problems, first, an internal standard to be detected simultaneously with a component for the analysis is mixed in a mobile phase or an eluate of a liquid chromatograph; under the condition where no quantitative analysis-inhibitory factors occur, a blank sample is analyzed to acquire a mass chromatogram of ions originated from the internal standard; and the result is stored in a data storage unit. Then, a sample for the analysis is mixed to acquire data for the analysis of the sample; and the intensity of ions originated from the internal standard is compared with that of the blank sample in the analysis real time in a data analysis unit. At this time, if an inconsistency exceeding a predetermined threshold is detected, the occurrence of the quantitative analysis-inhibitory factors can be detected. Further, based on the inconsistency, the error range of the data can be given to a data set and the like. | 05-05-2011 |
20110101216 | SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY - The invention provides for efficient collection of analyte ions and neutral molecules from surfaces for their subsequent analysis with spectrometry. In an embodiment of the invention, a ‘multiple desorption ionization source’ includes a tube which can contain ions for subsequent sampling within a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment, electrostatic fields are used to direct ions a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, either narrow inside diameter capillary tubes or wide diameter tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the invention, a dopant is introduced into a tube to analyze the sample. In an embodiment of the invention, a plurality of ionization sources is used to analyze the sample. | 05-05-2011 |
20110101217 | Mass Spectrometric Method for Matrix-Free Laser Desorption/Ionization of Self-Assembled Monolayers - Disclosed is a method for carrying out matrix-free mass spectrometry, which includes subjecting an analyte sample containing a self-assembled monolayer on the surface of a substrate to laser desorption/ionization. The method for carrying out matrix-free mass spectrometry involves simple pretreatment of an analyte sample with a cationic solution without using any solid matrix to cause effective laser desorption/ionization of the analyte sample, and minimizes a biochemical and physiological change in the sample that may occur during the pretreatment of the sample. In addition, the method is applicable to quantitative analysis because it provides high reproducibility of the results by virtue of the uniform treatment with the cationic solution over the whole areas of the sample. Further, the method enables two-dimensional mapping analysis. | 05-05-2011 |
20110101218 | Mass Spectrometer - A method of switching between two modes of power supply to a mass analyser is provided. In a first mode of operation, operated for a first predefined time duration, a first power supply, coupled to the mass analyser, generates a first non | 05-05-2011 |
20110108722 | Novel Biomarkers Of Biliary Tract Cancer - A method of detecting an abnormal amount of a biomarker associated with biliary tract cancer in a subject can comprise: a) quantitating an amount of a fragment of prothrombin having an m/z value of about 4204 m/z in a biological sample from the subject; and b) comparing the quantitated value obtained in (a) with a threshold value. | 05-12-2011 |
20110108723 | System and Method for Generating Sprays Using Electrical Fields - A device for generating sprays of charged droplets, and resulting nanoparticles, the device comprising a first needle connected to an electrical potential line to generate a first spray of charged particles from the first needle, and a second needle spaced apart from and facing the first needle, and connected to an electrical line configured to ground the second needle or to apply a voltage to the second needle that is the same polarity as the voltage applied to the first needle. The device also comprising an electric field modifier connected to the first needle, and configured to modify an electrical field to generate a second spray of charged particles from the second needle. | 05-12-2011 |
20110108724 | Apparatus, System and Method for Purifying Nucleic Acids - A chemical sample collection and detection system is disclosed. The chemical sample collection and detection system includes a sample collection device and a detection device. The sample collection device includes a housing having two opposite sides and at least one openings on each side to allow a fluid sample passing through the housing; and a sorbent material placed between the two opposite sides of the housing or a sorbent coated screen. The sorbent material adsorbs chemical vapors, and traps particles and aerosols in the fluid sample when the fluid sample passes the housing through the openings. The detection device includes an atmospheric pressure ionization source and an ion detector. The atmospheric pressure ionization source desorbs and ionizes the chemicals trapped/sorbed on the sorbent material and the ion detector analyzes the ions for the presence of the sorbed chemical. | 05-12-2011 |
20110108725 | NON-DESTRUCTIVE, HIGH ORDER HARMONIC ION MOTION IMAGE CURRENT DETECTION - The invention herein generally relates to non-destructive, high order harmonic ion motion image current detection. In certain embodiments, ion motion corresponding to high order harmonic frequencies, instead of the secular frequencies, is detected using image current detection with a constant excitation applied to the waveform signal. | 05-12-2011 |
20110108726 | IONIZATION ANALYSIS METHOD AND APPARATUS - It is arranged so that ions can be analyzed accurately and with high sensitivity. A first electrode | 05-12-2011 |
20110114833 | System and Method for Diversion of a Liquid Chromatography Eluant - In accordance with an embodiment of the invention, there is provided a method for reducing or eliminating matrix interfering components in a biopharmaceutical product in a liquid chromatography-mass spectrometry system. The method comprises diverting to waste the entire flow of an eluant emerging from liquid chromatography of a sample, for a time period to remove contaminants that cause matrix interference to a degree sufficient to allow a desired accuracy in detection of an extractable; and, after the time period, directing the entire flow of the eluant to a mass spectrometer to detect the presence of the extractable. | 05-19-2011 |
20110114834 | High Throughput Apparatus and Method for Multiple Sample Analysis - A high throughput apparatus for multiple sample analysis is disclosed. The high throughput apparatus for multiple sample analysis may include: a laser light source; a lens array configured to focus laser irradiated by the laser light source into a plurality of focused laser beams; and a focusing unit disposed between the lens array and a sample, the focusing unit configured to focus ions produced from the sample by the plurality of focused laser beams into a plurality of ion beams. A high throughput method for multiple sample analysis may include: producing a plurality of focused laser beams by focusing laser; ionizing a sample by irradiating the plurality of focused laser beams to the sample; and producing a plurality of ion beams by focusing ions, wherein the ions are produced from the sample by the plurality of focused laser beams. | 05-19-2011 |
20110114835 | Method Of Charge Reduction Of Electron Transfer Dissociation Product Ions - A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell | 05-19-2011 |
20110114836 | Method for Identifying the Elution Time of an Analyte - A method for determining a time of elution of a peptide of interest from a liquid chromatography column includes a step of obtaining chromatographic data for each of a plurality of candidate fragment ions of the peptide of interest. A time along a common chromatographic time is scale determined corresponding to maximum overlay of the ion signals measured for each of the plurality of candidate fragment ions. Finally, the determined time is assigned as the time of elution of the peptide of interest from the liquid chromatography column. In particular, the chromatographic data is acquired during selective reaction monitoring of an eluate from the liquid chromatography column containing the peptide of interest. The chromatographic data includes ion signals measured along the common chromatographic time scale for each of the plurality of candidate fragment ions. | 05-19-2011 |
20110121165 | Multi-element screening of trace elements - The present invention is concerned with methods and devices for sample collection and simultaneous detection and/or quantitation my mass spectrometry of multiple trace elements and/or metals in fluid samples. | 05-26-2011 |
20110121166 | USE OF CYANOCINNAMIC ACID DERIVATIVES AS MATRICS IN MALDI MASS SPECTROMETRY - The present invention relates to the use of cyanocinnamic acid derivatives as a matrix in the MALDI mass spectrometry of an analyte. | 05-26-2011 |
20110121167 | Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment. | 05-26-2011 |
20110121168 | Monitoring treatment of head and neck cancer patients with drugs EGFR pathway using mass spectrometry of patient samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment. | 05-26-2011 |
20110121169 | Monitoring treatment of colorectal cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment. | 05-26-2011 |
20110121170 | APPARATUS AND METHOD FOR PARALLEL FLOW ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY - Analyte ions entrained in a carrier gas are analyzed by parallel flow ion mobility spectrometry prior to analysis by a mass analyzer. An extended ion funnel is located in the vacuum system of the mass analyzer and has an ion focusing section and an ion mobility analyzing section. The carrier gas together with entrained ions is introduced into the ion focusing section where the ions are focused to the axis of the funnel by applied RF voltages. In the ion mobility section, the action of an RF quadrupolar field, the movement of the carrier gas and axial DC field, separates the ions on the basis of their mobilities. The mobility separated ions are released into the mass analyzer where the ions may be further separated on the basis of mass. | 05-26-2011 |
20110121171 | ION MOBILITY SPECTROMETER INSTRUMENT AND METHOD OF OPERATION - An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path. Techniques are disclosed for operating the ion mobility spectrometer to produce highly resolved ion mobility spectra. | 05-26-2011 |
20110121172 | MS/MS Data Processing - A method of identifying precursor ion species from their fragments comprises obtaining mass spectra of a plurality of precursor ion species and their fragments to high mass accuracy. The fragment mass spectrum, obtained from fragmentation of multiple precursor ion species, is then scanned it identify pairs of fragments whose combined mass matches the mass of one of the precursor ion species. Once pairs of fragment ion shave been matched to precursor ions, the composite fragment ion spectrum is broken down into portions, one per fragment pair. Analysis continues until no further pairs are identified. A simplified fragment ion spectrum is then reconstructed for each precursor sample ion by stitching together the broken down sections of the composite fragment spectrum. The resultant reconstructed, simplified fragment spectra are sent to a search engine which returns a score-sorted list of likely candidates for each synthetic fragment ion spectrum. | 05-26-2011 |
20110121173 | ION SOURCE MEANS FOR DESORPTION/IONISATION OF ANALYTE SUBSTANCES AND METHOD OF DESORBING/IONISING OF ANALYTE SUBSTANCES - The invention relates to an ion source means comprising at least one holding means for holding at least one sample to expose the sample to a mass spectrometer device, wherein the holding means comprises a structured sample support means for supporting the sample and/or a structured sample or sample comprising a structured surface, respectively. | 05-26-2011 |
20110127416 | Mass Spectrometer - A mass spectrometer is disclosed comprising a sampling cone ( | 06-02-2011 |
20110127417 | SYSTEM AND METHOD FOR COLLISIONAL ACTIVATION OF CHARGED PARTICLES - A collision cell is disclosed that provides ion activation in various selective modes. Ion activation is performed inside selected segments of a segmented quadrupole that provides maximum optimum capture and collection of fragmentation products. The invention provides collisional cooling of precursor ions as well as product fragments and further allows effective transmission of ions through a high pressure interface into a coupled mass analysis instrument. | 06-02-2011 |
20110127418 | MASS SELECTOR - A mass spectrometer and method for performing high resolution mass spectrometry are provided, the mass spectrometer comprising an electrostatic trap and mass analyzer. The electrostatic trap comprises entrance and exit ends, entrance and exit end ion mirrors, a central field-free region, and a longitudinal axis. The mass analyzer receives ions from the exit end. Ions are admitted into the electrostatic trap via the entrance end, trapping ions in the electrostatic trap, the ions oscillating between the entrance and exit end ion mirrors along the axis. The electrostatic trap waits for the ions to separate into bunches different m/z values via the oscillating, and then excites a given bunch of ions of a given m/z value along the axis until at least a portion of the given bunch overcomes a barrier field at the exit end ion mirror, exiting the electrostatic trap for analysis, leaving behind remaining ions. | 06-02-2011 |
20110127419 | METHOD FOR HIGH EFFICIENCY TANDEM MASS SPECTROMETRY - A system and method for performing MS/MS of everything are provided. Ionisable materials separated in order of molecular weight in a plurality of mass ranges are received at a mass spectrometer system in a given order in time, each mass range comprising a respective center mass value and a respective width. The ionisable materials are ionised in the given order that each of the plurality of mass ranges are received, to form respective precursor ions in a respective given mass range. The respective precursor ions are filtered via a mass filter module, a mass scan range of the mass filter module synchronized with the given order in which each of the plurality of mass ranges are received. The respective precursor ions are fragmented, via a fragmentation module, to form respective product ions. The respective product ions are analyzed in a mass spectrometer module to produce product ion spectra. | 06-02-2011 |
20110127420 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - A mass spectrometer and a mass spectrometry method adapted for mass spectrometry of a hardly volatile minuscule organic foreign matter of several μm often causing a device defect are disclosed. A sample gasified by a sample heating probe is introduced into an ion source, and the sample thus ionized is detected by being separated in accordance with the mass-to-charge ratio. In this mass spectrometry technique, the sample heating probe is covered with a cylindrical gas guide mechanism, and the gasified sample is led efficiently to the ion source by the gas guide mechanism, thereby making possible the contribution by the sample components which otherwise might be dispersed and wasted in the prior art. As a result, the mass spectrometry with higher sensitivity and S/N than in the prior art is realized. | 06-02-2011 |
20110133068 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 06-09-2011 |
20110133069 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydrorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 06-09-2011 |
20110133070 | DETECTION APPARATUS - A detection system comprises a housing having a sample inlet and a gas outlet, and a preconcentrator. The preconcentrator can include a microelectromechanical system (MEMS) configured to accumulate or release a dopant at selected times, and can be located inside or outside the housing. The detection system can include an ion mobility spectrometer, a mass spectrometer, or a combination thereof. A method of analyzing a substance comprises supplying a sample gas or vapor comprising the substance, accumulating a dopant in a first preconcentrator, releasing the dopant at selected times from the preconcentrator to an area containing the sample, ionizing the substance to generate detectable species, separating the detectable species, and determining the detectable species by a detection unit. The system and method allow the rapid introduction and removal of dopant to facilitate fast and accurate identification of the sample. | 06-09-2011 |
20110133071 | ION INDUCED IMPACT IONIZATION DETECTOR AND USES THEREOF - Disclosed are systems, devices and methodologies relating to an ion induced impact ionization detector and uses thereof. In certain implementations, the detector can include a dielectric layer having one or more wells. An anode layer defining apertures to accommodate the openings of the wells can be disposed on one side of the dielectric layer, and a cathode such as a solid resistive cathode can be disposed on the other side so as to provide an electric field in each of the wells. Various design parameters such as well dimensions and operating parameters such as pressure and high voltage are disclosed. In certain implementations, such an ion detector can be coupled to a low pressure gas volume to detect ionization products such as positive ions. Such a system can be configured to provide single ion counting capability. Various example applications where the ion detector can be implemented are also disclosed. | 06-09-2011 |
20110133072 | ION MOBILITY SPECTOMETER AND DETECTING METHOD USING THE SAME - An ion mobility spectrometer comprises an electrode and two storage electrodes disposed at the two opposite sides of the electrode respectively. Ions from an intermediate part between the two storage electrodes are stored and the stored ions are released from the storage electrodes by changing electric potentials of the two storage electrodes. The present invention further discloses a detecting method using an ion mobility spectrometer. | 06-09-2011 |
20110133073 | Method and Apparatus for Time-of-Flight Mass Spectrometry - A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory. | 06-09-2011 |
20110133074 | ANALYTICAL METHOD AND ANALYTICAL SYSTEM - Analytical method and analytical system are presented, wherein properties of the carrier gas conveying fine particles and gas components generated by laser ablation can be prevented from inhibiting the optimization of analysis conditions, and plural kinds of elements can be stably measured with high sensitivity and good accuracy without losing operability, speed, and convenience when fine particles generated by laser ablation are plasma-analyzed. A sample α is converted into fine particles by a laser ablation device in the atmosphere of a first gas. The fine particles are conveyed from the laser ablation device to a gas replacement device by using the first gas as a carrier gas. The first gas of at least part of the carrier gas conveying the fine particles is replaced with a second gas by means of the gas replacement device. The fine particles are conveyed from the gas replacement device to the plasma analyzer by the carrier gas that has been subjected to the gas replacement. Constituent elements of the fine particles are analyzed by the plasma analyzer. | 06-09-2011 |
20110139975 | TRACE DETECTOR AND ANALYTICAL METHOD FOR TRACE DETECTOR - A trace detector is disclosed. The trace detector comprises: a desorption chamber defining a desorption region, and the desorption chamber has a housing. The housing has a sample feeding port for introducing a substance to be detected into the desorption chamber and a gas discharge port for discharging gas entraining the sample from the desorption chamber. A controller is used for controlling the trace detector in such a manner that the sample feeding port and the gas discharge port are in fluid communication with the desorption chamber during pre-concentration process of the trace detector, thereby continuously feeding and collecting the sample. With the above manner, data collecting, processing and analyzing processes may be performed by the trace detector throughout the sample feeding process and the gas pre-concentrating process. The trace detector has an excellent detecting period of time whether the substance to be detected in the gas is in a high concentration state or a low concentration state, and the trace detector can perform continuous sampling for a long time, thereby improving a ratio of the amount of trapped substance to the amount of the substance entrained in the gas to be detected and the amount of the cumulated trapped substance, decreasing the probability of failing to detect the substance, and increasing detection sensitivity. In addition, the detection efficiency of the detector is increased during the gas pre-concentration process. | 06-16-2011 |
20110139976 | Method for operating three-dimensional RF ion traps with high ion capture efficiency - In a three-dimensional Paul RF ion trap the ring electrode and end cap electrodes are formed from pairs of pole rods. This multipole rod system is then operated as a linear ion trap with a constant field distribution along the multipole rod system. While the system is operating as a linear ion trap, analyte ions are introduced and stored within the linear ion trap. After the ions have been stored, a single-phase RF voltage is supplied to all rods of a middle segment thus forming a three-dimensional ion trap, thereby collecting the ions in a spherical cloud within this middle segment. The collected analyte ions can then be reacted in the three-dimensional ion trap and the product ions resulting from the reactions can be ejected for mass analysis. | 06-16-2011 |
20110139977 | MATRIX-ASSISTED LASER DESORPTION WITH HIGH IONIZATION YIELD - Analyte ions are generated in an ion source by matrix-assisted laser desorption (MALDI) in which laser light pulses have significantly less than one nanosecond duration, focal diameters of less than twenty micrometers and energy densities such that only about one picogram of sample is desorbed per pulse of laser light and per laser spot. An unexpectedly high degree of ionization of analyte molecules is produced for selected matrix substances. Many laser spots can be generated side-by-side from a single laser light pulse for use with MALDI time-of-flight mass spectrometers. Applying pulses with a repetition rate of around 50 kilohertz and moving the sample or guiding the laser light beam so each laser light pulse impinges on a cool sample spot allows the ion source to be used with spectrometers that require a constant ion current. | 06-16-2011 |
20110147575 | ION FUNNEL FOR MASS SPECTROMETRY - An interface for use in a mass spectrometer is disclosed. The interface comprises a first ion funnel comprising a first inlet and a first outlet, and a first axis between the first inlet and the first outlet. The interface further comprises a second ion funnel in tandem with the first ion funnel, the second ion funnel comprising a second inlet and a second outlet, and a second axis between the second inlet and the second outlet. The first axis and the second axis are offset relative to one another. A mass spectrometer comprising the interface and a method are disclosed. | 06-23-2011 |
20110147576 | Apparatus and Methods for Pneumatically-Assisted Electrospray Emitter Array - An electrospray ion source comprises a source of analyte-bearing liquid; a source of sheath gas; a plurality of liquid conduits, each configured so as to receive a portion of the analyte-bearing liquid; at least one electrode associated with the plurality of liquid conduits for producing electrospray emission of charged droplets from an outlet of each of the liquid conduits; a power supply electrically coupled to the at least one electrode for maintaining the at least one electrodes at an electrical potential; and either one or a plurality of sheath gas conduits, each sheath gas conduit comprising an inlet configured to receive sheath gas and an outlet configured to emit a sheath gas flow that circumferentially surrounds, in at least two dimensions, a portion of the emitted charged droplets. | 06-23-2011 |
20110147577 | Method and Apparatus for Multiple Electrospray Emitters in Mass Spectrometry - An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode provides a uniformity of emission of charged particles from the plurality of emitter tips. | 06-23-2011 |
20110147578 | TIME-OF-FLIGHT SPECTROMETRY AND SPECTROSCOPY OF SURFACES - Described is an analytical method and apparatus for counting and measuring the flight time of secondary electrons, secondary ions and neutrals, scattered ions and/or neutrals and for correlating coincidences between these while maintaining a continuous un-pulsed, micro-focused, primary particle beam for impinging a surface for purposes of microprobe imaging and microanalysis. | 06-23-2011 |
20110147579 | PARTICULATE MONITORING - A method for monitoring a quantity of a particle in a sample of air may include heating a particle to form a vapor; detecting the particle; measuring a change in quantity of the particle; and indicating the change in quantity. | 06-23-2011 |
20110147580 | ROTATOR SAMPLE INTRODUCTION INTERFACE - In one embodiment, the present invention relates generally to a rotator sample introduction interface. In one embodiment, the rotary interface for collecting an analyte includes a valve body, a rotor coupled to the valve body and a stator coupled to the rotor. In one embodiment, the rotor is channel-free and the stator includes a first channel and a second channel, wherein the first channel comprises an inlet for receiving a liquid and an outlet for expelling the liquid, wherein a carrier gas is provided via an inlet of the second channel and an outlet of the second channel is coupled to an analyzer. | 06-23-2011 |
20110147581 | APPARATUSES AND METHODS FOR PORTABLE MASS SPECTROMETRY - Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 10 | 06-23-2011 |
20110147582 | Multiple Ion Injection in Mass Spectrometry - This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions. | 06-23-2011 |
20110147583 | METHODS FOR DETECTING DEHYDROEPIANDROSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of DHEA in the sample. | 06-23-2011 |
20110155901 | Merged Ion Beam Tandem TOF-TOF Mass Spectrometer - A tandem time-of-flight mass spectrometer includes a first pulsed ion source that produces ions with a first mass and charge that directs the ions into a first stage of a tandem TOF mass spectrometer. In addition, a second pulsed ion source produces ions with a second mass and an opposite charge directs the ions into the first stage of the tandem TOF mass spectrometer. A field-free reaction region is positioned in the ion flight path so that ions from first and second pulsed ion source arrive at the entrance of the field-free reaction region substantially simultaneously in at least one of time and space. At least some of the ions from the first and second pulsed ion source are fragmented by ion-ion collision between positive and negative ions. A second stage of the tandem mass spectrometer separates fragment ions produced in the reaction region according to their mass-to-charge ratio. | 06-30-2011 |
20110155902 | METHODS AND SYSTEMS FOR PROVIDING A SUBSTANTIALLY QUADRUPOLE FIELD WITH A HIGHER ORDER COMPONENT - A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A2 and an octopole harmonic of amplitude A4, wherein A4 is greater than 0.01% of A2, A4 is less than 5% of A2, and, for any other higher order harmonic with amplitude An present in the field, n being any integer greater than 2 except 4, A4 is greater than ten times An. | 06-30-2011 |
20110155903 | SIMULTANEOUS INORGANIC MASS SPECTROMETER AND METHOD OF INORGANIC MASS SPECTROMETRY - An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an ICP mass spectrometer with an ICP ion source), an ion transfer region, an ion optics to separate ions out of a plasma beam, a Mattauch Herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before the entrance slit, and a solid state multi channel detector substantially separated from ground potential and separated from the potential of the magnet is introduced. | 06-30-2011 |
20110163226 | MEANS AND METHODS FOR ASSESSING LIVER TOXICITY - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol, myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (d18:1, C24:1), Ceramide (d18:2, C24:0), Sphingomyelin (d18:1, C16:0), 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, Coenzyme Q9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides. | 07-07-2011 |
20110163227 | Ion Trap for Cooling Ions - A method of changing the kinetic energy of ions is provided, comprising: trapping ions in a trapping region of an ion trap; and directing a beam of gas through the trapping region, so as to change the kinetic energy of the trapped ions thereby. Also provided is a method of separating ions, the method comprising: causing ions to enter a trapping region of an ion trap along a first axis of the trapping region; directing a beam of gas along the first axis and applying an electric potential in the direction of the first axis so as to cause separation of the ions based on their ion mobility. An ion trap and a mass spectrometer for performing the methods are also provided. | 07-07-2011 |
20110163228 | QUANTIFICATION METHOD OF FUNCTIONAL GROUPS OF ORGANIC LAYER - A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c). | 07-07-2011 |
20110168880 | TIME-OF-FLIGHT MASS SPECTROMETER WITH CURVED ION MIRRORS - A mass spectrometer includes: an accelerator for receiving ions travelling in a drift direction and accelerating the ions in an acceleration direction orthogonal to the drift direction; a detector downstream of the accelerator with respect to the drift direction; and an ion mirror assembly intermediate the accelerator and the detector. The ion mirror assembly includes at least a first ion mirror and a second ion mirror spaced apart from each other in the acceleration direction. The accelerator, detector, and ion mirror assembly provide a folded ion path between the accelerator and the detector for separating the ions according to their mass-to-charge ratio so that a flight time of the ions is substantially independent of ion energy. The first and second ion mirrors each apply an electrostatic potential to the ions that is curved in both the drift direction and a lateral direction orthogonal to both the drift and acceleration directions. | 07-14-2011 |
20110168881 | PLASMA-BASED DIRECT SAMPLING OF MOLECULES FOR MASS SPECTROMETRIC ANALYSIS - A plasma-based dielectric barrier discharge (DBD) ion source is configured for flowing afterglow sampling and ionization of analytes. A method of direct sampling for mass spectrometric analysis includes providing an afterglow from a dielectric barrier discharge (DBD) plasma device, directing the afterglow with a flow of heated plasma support gas to a sample positioned externally to the DBD device, ionizing at least a portion of the sample with the afterglow and heated gas, and, analyzing ionized species from the sample in a mass spectrometer. A system for mass spectrometric analysis of a sample includes a mass spectrometer having an entrance aperture, and, a dielectric barrier discharge (DBD) ion source having a heated plasma support gas for directing DBD afterglow to a sample positioned between the DBD ion source and the entrance aperture of the mass spectrometer. | 07-14-2011 |
20110174964 | CONTINUOUS FLOW MOBILITY CLASSIFIER INTERFACE WITH MASS SPECTROMETER - A continuous flow mobility classifier provide the ability to perform two-dimensional separation in mass spectrometry. An ionization system is used to ionize a sample. A differential mobility analyzer (DMA) (e.g., a nano-radial DMA) is coupled to the ionization system and to a mass spectrometer. The nano-RDMA is configured to separate the ionized sample by mobility for subsequent mass analysis by the mass spectrometer. | 07-21-2011 |
20110180699 | DEVICE AND METHOD USING MICROPLASMA ARRAY FOR IONIZING SAMPLES FOR MASS SPECTROMETRY - A device includes a first substrate having a principal surface having a plurality of sample sites having a corresponding sample; a second substrate having a principal surface facing and spaced apart from the principal surface of the first substrate, the second substrate having a plurality of ultraviolet emission sites corresponding to the sample sites of the first substrate, each of the ultraviolet emission sites being spaced apart from and facing a corresponding one of the sample sites of the first substrate, each of the ultraviolet emission sites being configured to emit ultraviolet light to a corresponding one of the sample sites on the first substrate, and to ionize at least a portion of a sample provided at each sample site; and an ion extraction device configured to extract ions from a gap between the first substrate and the structure. | 07-28-2011 |
20110180700 | WIND AND TEMPERATURE SPECTROMETER WITH CROSSED SMALL-DEFLECTION ENERGY ANALYZER - A wind and temperature spectrometer (WTS) may detect the angular and energy distributions of neutral atoms/molecules and ions in two mutually perpendicular planes. The measured energy distribution at a known angle near the peak may be used to infer the full wind vector W. A WTS having a single ion source may be used in conjunction with a crossed small-deflection energy analyzer (SDEA). The crossed SDEA may combine the angular and energy distributions in the two mutually perpendicular planes into a single spectrometer with a single optical axis. A WTS having a single ion source may use less energy and occupy less space than a WTS with two ion sources. | 07-28-2011 |
20110180701 | NANOPARTICLE ELECTROSTATIC TRAP - A method of trapping a charged particle. The method includes providing a planar substrate having a conductive surface thereon, the conductive surface having at least one non-conductive region. The method also includes applying a solution to the conductive surface, the solution comprising at least one charged particle. The method further includes applying a voltage of a threshold level to the conductive surface. The method also includes, in response to the voltage, generating an electrostatic field in the solution adjacent to a boundary between the conductive surface and the non-conductive region. The method also includes setting the threshold level of voltage to result in a strength of the electrostatic field sufficient to prevent the particle from crossing the electrostatic field. | 07-28-2011 |
20110180702 | CENTRAL LENS FOR CYLINDRICAL GEOMETRY TIME-OF-FLIGHT MASS SPECTROMETER - A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite to each other, parallel to each other, and axially offset from each other. The electrode structures are configured to generate, in response to an applied voltage, a cylindrically-symmetric, annular electric field comprising an annular radially focusing central lens region surrounding an axis of symmetry, and an annular mirror region surrounding the annular radially focusing central lens region. | 07-28-2011 |
20110180703 | METHOD FOR THE DIAGNOSIS OF NON-ALCOHOLIC STEATOHEPATITIS BASED ON A METABOLOMIC PROFILE - The invention relates to methods for the diagnosis of non-alcoholic steatosis (NASH). The method relies on the determination of certain metabolic markers in a biological sample of the patient which are up- or down-regulated in the NASH patients vs. patients with a simple fatty liver (steatosis). | 07-28-2011 |
20110180704 | Mass Spectrometer - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 07-28-2011 |
20110186724 | Dual Ion Trapping for Ion/Ion Reactions In A Linear RF Multipole Trap With An Additional DC Gradient - A novel method and mass spectrometer apparatus is introduced to enable the simultaneous isolation of cations and anions (i.e., precursor and reagent ions) in a linear multipole ion trap via the application of an additional axial DC gradient in combination with coupled RF potential(s). Thus, the combination of the RF and DC voltages in such an arrangement forms a pseudopotential designed to provide for minima for the trapped positively and negatively charged particles that result in the overlap of the ion clouds so as to provide for beneficial ion/ion reactions. | 08-04-2011 |
20110186725 | METHOD FOR SEQUENCING PEPTIDES AND PROTEINS USING METASTABLE-ACTIVATED DISSOCIATION MASS SPECTROMETRY - Methods for fragmentation of large molecular ions, including proteins, nucleic acids, dendromers, and nanomaterials, compatible with several mass spectrometric techniques. The methods involve providing a gas-phase ion and allowing the gas phase ion to undergo collisions with metastable states of noble gases or nitrogen gas. | 08-04-2011 |
20110186726 | SAMPLE CONTROL FOR IMPROVED SENSITIVITY AND CLEAR DOWN TIMES FOR A MEMBRANE BASED IMS - An analytical instrument that includes a chemical substance analyzer. The chemical substance analyzer includes a desorber, a swab receptacle forming a chemical substance entrainment area proximate the desorber, a conduit in fluid communication with the entrainment area, and a membrane, wherein the membrane extends across a cross-section of the conduit, wherein the membrane is positioned to have a desorber side in gas communication with the desorber and an analysis side opposite the desorber side. A the first volumetric flow rate is less than a specified amount per a cross-sectional conduit area. | 08-04-2011 |
20110186727 | METHOD AND SYSTEM FOR OPERATING A TIME OF FLIGHT MASS SPECTROMETER DETECTION SYSTEM - Dual TDC-ADC detection systems for time of flight mass spectrometry are disclosed herein. Detection systems based upon TDC generally provide higher timing resolution as opposed to detection systems based upon ADC. However, ADC generally provides increased dynamic range over TDC. By combining TDC and ADC into a tandem detector, and adjusting performance parameters of the respective converter types, the dynamic range of the dual TDC-ADC detection can be extended beyond what either detector type could have achieved individually. Composite time of flight mass spectra can be generated by aggregating individual mass spectra acquired from multiple time-of-flight extractions, and selecting the number of time-of-flight extractions to ensure overlap between the ADC and TDC dynamic ranges in the dual TDC-ADC detector system. | 08-04-2011 |
20110186728 | ION MANIPULATION CELL WITH TAILORED POTENTIAL PROFILES - An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell. | 08-04-2011 |
20110186729 | QUASI-PLANAR MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER - A multi-reflecting time-of-flight (MR-TOF) mass spectrometer, which includes two quasi-planar electrostatic ion mirrors extended along drift direction (Z) and is formed of parallel electrodes, separated by a field-free region. The MR-TOF includes a pulsed ion source to release ion packets at a small angle to X-direction which is orthogonal to the drift direction Z. Ion packets are reflected between ion mirrors and drift along the drift direction. The mirrors are arranged to provide time-of-flight focusing ion packets on the receiver. The MR-TOF mirrors provide spatial focusing in the Y-direction orthogonal to both drift direction Z and ion injection direction X. In a preferred embodiment, at least one mirror has a feature providing periodic spatial focusing of ion packets in the drift Z-direction. | 08-04-2011 |
20110192968 | Multi-Needle Multi-Parallel Nanospray Ionization Source for Mass Spectrometry - An electrospray ion source for a mass spectrometer includes an electrode comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; a conduit for delivering an analyte-bearing liquid to the electrode; and a voltage source, wherein, in operation of the electrospray ion source, the analyte-bearing liquid is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source. | 08-11-2011 |
20110192969 | METHOD AND APPARATUS FOR ION MANIPULATION USING MESH IN A RADIO FREQUENCY FIELD - Ion manipulation systems include ion repulsion by an RF field penetrating through a mesh. Another comprises trapping ions in a symmetric RF field around a mesh. The system uses macroscopic parts, or readily available fine meshes, or miniaturized devices made by MEMS, or flexible PCB methods. One application is ion transfer from gaseous ion sources with focusing at intermediate and elevated gas pressures. Another application is the formation of pulsed ion packets for TOF MS within trap array. Such trapping is preferably accompanied by pulsed switching of RF field and by gas pulses, preferably formed by pulsed vapor desorption. Ion guidance, ion flow manipulation, trapping, preparation of pulsed ion packets, confining ions during fragmentation or exposure to ion to particle reactions and for mass separation are disclosed. Ion chromatography employs an ion passage within a gas flow and through a set of multiple traps with a mass dependent well depth. | 08-11-2011 |
20110192970 | METHOD AND APPARATUS FOR MASS SPECTROMETRY - For the achievement of data transfer time reduction, removal of noise data, and analytical efficiency improvement in an ADC data processing function of a time-of-flight mass spectrometer, the mass spectrometer comprises a data acquisition circuit including: an ND converter; a signal intensity addition memory that stores data of ion signals such as a time range and the number of measurements and performs an addition process; a voltage value frequency addition memory that performs an addition process of frequencies of voltage values of the predetermined time range and the number of measurements and stores addition results; a threshold level computation circuit that computes a predetermined threshold level from the results in the memory; a compression memory that extracts only data exceeding the threshold level from the data in the signal intensity addition memory; and a counter that controls a measurement time for data acquisition and the operation of each circuit. | 08-11-2011 |
20110192971 | Mass-Analyzing Method - A variety of ions generated in an ion source are made to fly while bypassing a loop orbit and mass analyzed to create a mass spectrum. Among the peaks appearing on the mass spectrum, peaks complying with predetermined conditions are extracted to determine a plurality of mass ranges to be measured (S | 08-11-2011 |
20110198490 | PULSED FLOW ION MOBILITY SPECTROMETER - An ion mobility spectrometer is described which makes use of a pulsed flow pump to draw gas through an ion filter in pulsed operation. A gas counterflow may also be provided, in some embodiments this may also be a pulsed counterflow. | 08-18-2011 |
20110198491 | MASS SPECTRAL ANALYSIS OF COMPLEX SAMPLES CONTAINING LARGE MOLECULES - The present invention provides, inter alia, methods of analyzing mass spectral data based on charge states of analyte ions. In some embodiments, the methods can be used for differential profiling of samples, such as comparing a sample comprising a given compound and a sample comprising metabolites of the same compound. The methods can also be used to identify and isolate biomarkers. Systems for performing the methods, as well as computer-readable media for performing the methods, are also described. | 08-18-2011 |
20110198492 | Detection and Quantitation of Pain Medications in Oral Fluid Specimens - A method for the detection and quantitation of pain medication in oral fluid specimens is provided. First, a Solid Phase Extraction (“SPE”) process is used to isolate cocaine and its metabolite, amphetamines and/or butalbital from human oral fluid samples. Alternatively, Liquid-Liquid Extraction (“LLE”) is used to isolate methadone and its metabolite, fentanyl and norfentanyl, buprenorphine and norbuprenorphine, propoxyphene and norpropoxyphene, carisoprodol, meprobamate, a series of benzodiazepines, tramadol and its metabolites, the analgesic opioids, and tetrahydrocannabinol (“THC”) and its carboxylated metabolite (“THC-C”). Finally, following isolation of these drugs and their metabolites, they are separated respectively using a high performance liquid chromatographic column and a novel combination chromatographic solvents and gradients. All analytes are detected and quantified using a tandem mass spectrometry (“MS/MS”) precursor to produce ion transitions. | 08-18-2011 |
20110198493 | ION MOBILITY SPECTROMETER WITH ONE OR MORE INTEGRAL ION ACTIVATION REGIONS - An ion mobility spectrometer comprises a drift tube defining a drift tube inlet configured to receive ions and a drift tube outlet. The drift tube is configured to separate ions in time as a function of ion mobility. The drift tube defines a first ion activation region between the drift tube inlet and the drift tube outlet. The first ion activation region is configured to selectively induce structural changes in at least some of the ions. | 08-18-2011 |
20110198494 | MASS DISCRIMINATOR - An analysis device for mass discrimination is disclosed. The analysis device comprises: a sample chamber for holding a gaseous sample; an analysis chamber arranged to receive sample gas from the sample chamber; a mass discriminator arranged to discriminate in the analysis chamber between ion species generated from the sample gas; and a wall separating the sample chamber from the analysis chamber, the wall comprising a rupture zone controllable to rupture and thereby release sample gas from the sample chamber into the analysis chamber. In one embodiment the rupture zone is adapted to rupture on application of an electric current or mechanical force. The wall may be micromachined. A method of mass discrimination is also disclosed. | 08-18-2011 |
20110198495 | IONIZATION METHOD AND APPARATUS USING A PROBE, AND ANALYTICAL METHOD AND APPARATUS - The tip of an electrically conductive probe | 08-18-2011 |
20110204218 | Method of Processing Ions - A method for obtaining fragment ions having product ion spectrum with a mixture of high, medium and lower energy product ions. The method includes (a) providing a selected RF field to an ion optical element upstream of an ion containment field; (b) transmitting ions through the ion optical element and into the ion containment field such that the selected RF field determines, at least in part, a selected kinetic energy profile of the ions within the ion containment field, wherein the selected kinetic energy profile is selected to fragment the ions to concurrently provide a plurality of groups of product ions; and (c) detecting each group of product ions in the plurality of groups of product ions. | 08-25-2011 |
20110204219 | SYSTEM AND METHODS FOR DETERMINING MOLECULES USING MASS SPECTROMETRY AND RELATED TECHNIQUES - The present invention generally relates to mass spectrometry and related techniques, and in some cases, to determining single species using mass spectrometry. In certain instances, polymers such as DNA or RNA can also be sequenced. Certain embodiments of the invention relate to passing a polymer, such as DNA, RNA, a protein, a polypeptide, a polysaccharide, etc., through a pore and cleaving the polymer in sequence. For instance, the polymer may be cleaved using a laser or an electric field. In some embodiments, a property of at least one subunit of a polymer is determined using mass spectrometry. In some embodiments, a single ion (which may be a subunit of a polymer, or an ion based on another species) can be isolated in a mass spectrometer and a signal generated from the single ion. | 08-25-2011 |
20110204220 | Method and Apparatus for Identification of Biological Material - Biological material is detected in a sample using a MALDI-MS technique (Matrix Assisted Laser Desorption and Ionization-Mass Spectroscopy). A liquid comprising the sample and a MALDI matrix material is prepared and used to form a continuous stream of the liquid. The stream is separated into successive parts to form drops, which are launched into flight, or the stream is launched into flight and then separated into drops. Drop forming techniques may be used that are known from ink jet printers. Material from the drops is ionized while in flight. Mass spectra from the ionized material of respective drops are measured. Preferably, before the drops are formed the liquid is diluted to a level where the majority of drops at most one micro-organism is present per drop. | 08-25-2011 |
20110204221 | MASS SPECTROMETER AND METHOD OF MASS SPECTROMETRY - When a high-speed analyzer such as a quadrupole mass filter is united with an analyzer which requires a reaction time of 10 msec, such as an ion dissociation chamber of the ion trap type, a problem arises that an ion loss occurs due to a difference in analysis speed between the analyzers. A high-throughput analysis is intended to be achieved by eliminating this loss. A pre ion trap ( | 08-25-2011 |
20110204222 | METHOD OF CHARACTERIZING PHYTOCHEMICALS FROM TRIGONELLA FOENUM GRACEUM - The present invention relates to identification and characterization of Phytochemicals and metabolites from | 08-25-2011 |
20110210240 | Enhanced Resolution Mass Spectrometer and Mass Spectrometry Method - A mass spectrum is generated by a process in which, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak is selected. One or more synthesized samples are synthesized from the subset of the original samples. The one or more synthesized samples provide a temporal resolution greater than the temporal resolution of the original samples. The one or more synthesized samples are summed with respective temporally-aligned accumulated samples to produce the mass spectrum. The accumulated samples are obtained from mass scan signals generated during respective previously-performed mass scan operations. | 09-01-2011 |
20110210241 | Gas Delivery System For Mass Spectrometer Reaction And Collision Cells - A gas delivery system for a cell-based mass spectrometer includes a mass flow controller having an input coupled to a gas source. A three-way valve includes an input coupled to an output of the mass flow controller, a first output coupled to a vacuum system, and a second output normally coupled to a reaction or collision cell. A cell is positioned inside a vacuum chamber of the mass spectrometer where the second output of the three-way valve is coupled to an inlet of the cell and the mass flow controller provides a gas to the cell that increases a pressure inside the cell relative to the pressure in the vacuum chamber. | 09-01-2011 |
20110210242 | Ion Source with Device for Oxidising a Sample - An ion source is disclosed wherein a sample is introduced into the sample chamber ( | 09-01-2011 |
20110210243 | Metastable CID - Systems and methods of generating ions at atmospheric pressure are presented. These systems and methods include spatially dependent analysis of a sample using an effusive ionization source. Systems and methods of isolating samples at atmospheric pressure are presented. These systems and methods include using a barrier to prevent metastables or electrons from an effusive ion source from reaching a sample unless the sample is in an analysis position. Systems and methods of using metastables in collisionally induced dissociation are presented. | 09-01-2011 |
20110215235 | Quadrupole Mass Spectrometer With Enhanced Sensitivity And Mass Resolving Power - A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector. The linearity of the detected quadrupole ion current in combination with it reproducible spatial-temporal structure enables the deconvolution of the contributions of signals from individual ion species in complex mixtures where both sensitivity and mass resolving power are essential. | 09-08-2011 |
20110215236 | Electron Cooling System and Method for Increasing the Phase Space Intensity and Overall Intensity of Ion Beams in Multiple Overlap Regions - An electron cooling system and method for increasing the phase space intensity and overall intensity of ion beams in multiple overlap regions, including a vacuum chamber to allow a single electron beam to be merged and separated with multiple ion beams, an electron supply device including a cathode to generate the electron beam, an electron collector device including a collection plate to collect the electron beam, multiple magnetic field generation devices to guide the electrons on their desired trajectories, and multiple electrodes to set the velocity of the electron beam independently in each overlap region. By overlapping the electron and ion beams, thermal energy is transferred from the ion beams to the electron beam, which allows an increase in the phase space density and overall density of the ion beams. Advantageously, the electron cooling system uses multiple magnetic field generation devices to guide the electrons into and out of multiple, separate, ion beam overlap regions, allowing the single electron beam to cool an ion beam in more than one overlap region. Advantageously, the electron cooling system uses electrodes to control the mean electron beam velocity in each overlap region, allowing for mitigation of electron beam emittance growth caused by scattering that occurs exterior to the overlap regions. Advantageously, the electrodes used to control the mean electron beam velocity in each overlap region allow for a single electron beam to achieve different velocities to match different desired ion beam velocities in the multiple overlap regions. | 09-08-2011 |
20110215237 | Mass Analysis Using Alternating Fragmentation Modes - A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Capture Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Capture Dissociation fragmentation device. | 09-08-2011 |
20110215238 | Mass-Analyzing Method and Mass Spectrometer - In a time-of-flight spectrum obtained when the overtaking of ions of different kinds has occurred, mass-to-charge ratios M | 09-08-2011 |
20110220784 | FOCUSED ANALYTE SPRAY EMISSION APPARATUS AND PROCESS FOR MASS SPECTROMETRIC ANALYSIS - An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization of the analyte. | 09-15-2011 |
20110220785 | METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay. | 09-15-2011 |
20110226941 | Techniques For Performing Retention-Time Matching Of Precursor And Product Ions And For Constructing Precursor And Product Ion Spectra - Techniques are described for matching a precursor ion with one or more related product ions, including providing a plurality of input data sets obtained from a plurality of injections, each of the plurality of input data sets including a same precursor ion and one or more product ions, normalizing the plurality of input data sets in accordance with a single retention time for the precursor ion, for each of the plurality of input data sets, determining which product ions are within a predetermined retention time window with respect to the single retention time for the precursor ion, and if a product ion is within the predetermined retention time window in at least one of the plurality of input data sets, determining that the product ion is related to the precursor ion having the single retention time | 09-22-2011 |
20110226942 | COMPOSITIONS, KITS, AND METHODS FOR CALIBRATION IN MASS SPECTROMETRY - The invention provides compositions, kits, and methods for calibrating a mass spectrometer using two or more recombinant proteins and one or more energy-absorbing molecules. The recombinant proteins of the invention display high purities, making them suitable for use in mass spectrometry. | 09-22-2011 |
20110226943 | SATURATION CORRECTION FOR ION SIGNALS IN TIME-OF-FLIGHT MASS SPECTROMETERS - A method for increasing a dynamic measurement range of a mass spectrometer, includes replacing measured values in saturation with correction values, and summing the correction values to provide a sum spectrum. | 09-22-2011 |
20110226944 | VITAMIN D METABOLITE DETERMINATION UTILIZING MASS SPECTROMETRY FOLLOWING DERIVATIZATION - The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry. | 09-22-2011 |
20110226945 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 09-22-2011 |
20110226946 | DETERMINATION OF TESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d | 09-22-2011 |
20110233395 | VITAMIN D DEFICIENCIES - Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided. | 09-29-2011 |
20110233396 | Mass Spectrometer - A mass analyser | 09-29-2011 |
20110240839 | SAMPLE CHAMBER FOR LASER ABLATION INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY - An improved sample chamber for laser assisted spectroscopy integrates valve mechanisms into the sample drawer, permitting the sample chamber to automatically bypass, purge and resume flow as the sample drawer is opened and closed to insert samples for processing. Integrating valve mechanisms into the sample drawer in this manner eliminates the need for external valves to be operated to bypass, purge and resume flow, thereby increasing system throughput and reducing system complexity. | 10-06-2011 |
20110240840 | MASS SPECTROMETRIC DETERMINATION OF COOKSON-DERIVATIZED, NON-METABOLIZED VITAMIN D - The invention relates to the detection of vitamin D. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D by mass spectrometry. | 10-06-2011 |
20110240841 | Methods and Apparatus for Producing a Mass Spectrum - The invention provides a method of producing a mass spectrum, comprising:
| 10-06-2011 |
20110240842 | Methods and Systems for the Quantitative Analysis of Biomarkers - Disclosed are methods and systems using liquid chromatography/tandem mass spectrometry (LC-MS/MS and 2D-LC-MS/MS) for the analysis of endogenous biomarkers, including steroid hormones, such as estrone and estradiol, thyroid hormones, such as free thyroxine, and metabolites, such as 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, in biological samples. | 10-06-2011 |
20110240843 | METHODS FOR DETECTING CATECHOLAMINES BY MASS SPECTROMETRY - Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample. | 10-06-2011 |
20110240844 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 10-06-2011 |
20110240845 | MASS ANALYZER - A mass spectrometric analyzer and an analysis method based on the detection of ion image current are provided. The method in one embodiment includes using electrostatic reflectors or electrostatic deflectors to enable pulsed ions to move periodically for multiple times in the analyzer, forming time focusing in a portion of the ion flight region thereof, and forming an confined ion beam in space; enabling the ion beam to pass through multiple tubular image current detectors arranged in series along an axial direction of the ion beam periodically, using a low-noise electronic amplification device to detect image currents picked up by the multiple tubular detectors differentially, and using a data conversion method, such as a least square regression, to acquire a mass spectrum. | 10-06-2011 |
20110240846 | SEMICONDUCTOR DEVICE, METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE, APPARATUS FOR MANUFACTURING SEMICONDUCTOR DEVICE, AND METHOD FOR EVALUATING SEMICONDUCTOR DEVICE - The present teachings provide a method for manufacturing a semiconductor device including a semiconductor substrate and a lower surface electrode in which an aluminum containing layer, a titanium layer, a nickel layer, and a nickel oxidation-prevention layer are laminated in order from a semiconductor substrate side, wherein the titanium layer of the lower electrode is formed by sputtering in an atmosphere of a partial pressure of oxygen being equal to or less than 5×10 | 10-06-2011 |
20110248157 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - Objects of the present invention is to provide a quadrupole mass filter that can be fabricated at low cost and has a high transmission efficiency even under a high pressure (0.5 mTorr or more), and to provide a mass spectrometer or mass spectrometry method that reduces crosstalk in a wide mass range. Now, in a mass spectrometer, an ion separating unit is configured to include quadrupole rod electrodes that form a quadrupole radio-frequency electric field, electrodes that form a quadrupole electrostatic field, and a power supply that allows the voltage of the electrodes to form a quadrupole electrostatic field to change. In a collision cell configured to perform collision induced dissociation, harmonic potentials in a plurality of stages are produced to resonance excite ions in the axial direction, so that the ions obtain kinetic energy to move in the direction of the detector. This energy allows a time period to shorten for which ions stay in the collision cell. | 10-13-2011 |
20110248158 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 10-13-2011 |
20110253888 | INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER - A mass analysis system including a sample inlet arranged to introduce a sample and an ion source coupled to the sample inlet and arranged to ionize a portion of the sample into ions. The system also includes a sampler element having a sample orifice arranged to receive the sample ions into a first vacuum chamber. The system includes a skimmer element having a skimmer orifice arranged to receive the sample ions from the first vacuum chamber into a second vacuum chamber where the skimmer orifice is of a first size. The system further includes a third cone element having a third cone orifice of a second size arranged to receive the sample ions from the second vacuum chamber into a third vacuum chamber where the third cone is configured to allow a continuum flow of ions through the third cone orifice. The third chamber includes an ion optics assembly and mass analyzer. | 10-20-2011 |
20110253889 | ANALYZER, IONIZATION APPARATUS AND ANALYZING METHOD - An analyzer performs dielectric barrier discharge and ionization of a sample by a reaction between the sample and excited molecules or ions generated by the dielectric barrier discharge at a pressure lower than an atmospheric pressure. | 10-20-2011 |
20110260047 | SILABORANE IMPLANTATION PROCESSES - Methods for implanting an silaborane molecule or a selected ionized lower mass byproduct into a workpiece generally includes vaporizing and ionizing silaborane molecule in an ion source to create a plasma and produce silaborane molecules and its ionized lower mass byproducts. The ionized silaborane molecules and lower mass byproducts within the plasma are then extracted to form an ion beam. The ion beam is mass analyzed with a mass analyzer magnet to permit selected ionized silaborane molecules or selected ionized lower mass byproducts to pass therethrough and implant into a workpiece. | 10-27-2011 |
20110260048 | Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member - An ion transfer tube having an ion inlet and an ion outlet comprises: a first tube member comprising an electrically resistive material and having a first end comprising the ion inlet and a second end; a first electrode electrically coupled to the first tube member; a second tube member having a first end in leak-tight contact with the second end of the first tube member and a second end comprising the ion outlet; a second electrode electrically coupled to either the first tube member or the second tube member; and a heater thermally coupled to at least one of the tube members, wherein, in operation, an electrical potential difference applied between the electrodes produces an electric field within the first tube member that urges charged particles through the first tube member into the second tube member and the heater supplies heat to the charged particles within the ion transfer tube. | 10-27-2011 |
20110260049 | Method And Apparatus For Identifying Proteins In Mixtures - Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed and a target peptide is selected from produced peptides. The masses of the Y- and B-ion fragments of the target peptide are determined. These masses are used to search previously obtained low- and high-energy AMRTs obtained from LC/MS analysis of the complex sample for masses on the list. Any mass observed in the data within a detection threshold are considered a hit. If enough hits accumulate in a given retention time, the target peptide is identified as being in the sample. The list of peptides identified in the complex sample can be used to identify the proteins present in the sample, track the chromatographic retention times of peptides between samples, and quantitate the peptides and proteins present in complex samples. | 10-27-2011 |
20110260050 | DIFFERENTIAL MOBILITY SPECTROMETER AND OPERATING METHOD THEREFOR - A method of operating a differential mobility spectrometer includes an ionization chamber, a filter channel and a detection region. In the ionization chamber, analyte ions are produced from a sample, the so-obtained ions are then subjected in the filter channel to a time-varying electric field. The time-varying electric field has a longitudinal field component drawing the analyte ions from the ionization chamber through the filter channel into the detection region and a transversal field component, which is the superposition of an asymmetrically oscillating transversal field causing the analyte ions to move to and fro in transversal direction and a compensation field for selecting a species of analyte ions by substantially canceling the average transversal velocity of the selected species. Analyte ions of the selected species having passed through the filter channel are collected in the detection region and a detection signal responsive to the number of analyte ions collected is generated as a function of the compensating field. The longitudinal field component oscillates in longitudinal direction in such a way that it imparts to the analyte ions on average a non-zero longitudinal velocity in direction of the detection region while it causes them, on a shorter time scale, to move to and fro in longitudinal direction in the filter channel. | 10-27-2011 |
20110260051 | METHOD FOR DETECTING TRACER COMPOUNDS FOR HYDROCARBON PRODUCTION - The invention concerns a method for surveying a subsurface formation containing hydrocarbons, comprising:
| 10-27-2011 |
20110260052 | BENEFIT COMPOSITIONS COMPRISING POLYGLYCEROL ESTERS - The instant disclosure relates to compositions comprising selected polyglycerol esters and a treatment and/or care agent. The disclosed compositions may be useful in fabric care compositions, for example, detergents, fabric softening compositions and the like. Methods of making and using compositions comprising polyglycerol esters and a treatment and/or care agent are also disclosed. | 10-27-2011 |
20110260053 | ION SELECTION APPARATUS AND METHOD - An ion mobility spectrometer or other ion apparatus has two or three grid electrodes | 10-27-2011 |
20110266429 | SURFACE ENHANCED RAMAN SPECTROSCOPY DETECTION WITH ION SEPARATION PRE-FILTER - Detecting and identifying ions using surface enhanced Raman spectroscopy (SERS) and an ion separation pre-filter, such as an ion spectrometer, are provided. The combination of an ion separator as a pre-filter for SERS provides a highly sensitive detector with very low false alarm rates. Target ions from an ionized sample are identified and separated by the ion separator. The target ions are steered and deposited onto a SERS substrate for Raman spectroscopic analysis with an optical probe. The Raman spectrum is compared with reference spectra and the composition of the sample is identified. The ion current from the target ions can also be measured, preferably concurrently with the Raman spectrum measurement. Types of ion separators include a differential ion mobility spectrometer, an ion mobility spectrometer, or a mass spectrometer. | 11-03-2011 |
20110266430 | GAS INLET FOR A PROCESS MASS SPECTROMETER - An inlet for a process mass spectrometer, the inlet comprising, a capillary in fluid communication with a sample gas feed; a transfer line in fluid communication to the capillary; a first orifice configured to generate a change in pressure, the orifice comprising at least two measuring ports; a pressure sensor operatively connected to at least one of the two measuring ports; and a second transfer line in fluid communication with the first orifice, the second transfer line also in fluid communication with an external disposal point. | 11-03-2011 |
20110266431 | Tandem TOF Mass Spectrometer With High Resolution Precursor Selection And Multiplexed MS-MS And MS-MS Operation - A tandem time-of-flight mass spectrometer includes a first TOF mass analyzer that generates an ion beam comprising a plurality of precursor ions and that selects a group of precursor ions from the plurality of precursor ions. A first pulsed ion accelerator accelerates the selected group of precursor ions. A first ion fragmentation chamber fragments at least some of the selected group of precursor ions. A second pulsed ion accelerator accelerates the selected group of precursor ions and fragments thereof. A second ion fragmentation chamber further fragments at least some of the selected group of precursor ion fragments. A second TOF mass analyzer separates the fragments and detects a fragment ion mass spectrum. | 11-03-2011 |
20110266432 | Input Port for Mass Spectrometers that is Adapted for use with Ion Sources that Operate at Atmospheric Pressure - A mass spectrometer and method for operating the same. The mass spectrometer includes a vacuum chamber and an input port that receives ions to be analyzed in the mass spectrometer. The chamber is adapted to operate at a pressure less than a first pressure, and includes a wall that separates the chamber from an environment outside the chamber at atmospheric pressure. The input port provides a pressure drop between the outside environment at a second pressure and the chamber. The input port includes a plurality of channels, each channel having first and second electrodes arranged on opposing surfaces of that channel and having first and second ends. The first end of each channel is at a pressure equal to the first pressure and the second end is at a pressure less than the second pressure. | 11-03-2011 |
20110266433 | Apparatus And Methods For Gas Chromatography - Mass Spectrometry - The invention provides improved apparatus for, and methods of, ionizing analyte molecules in a flow of gas, typically at or around atmospheric pressure. The invention may be used to facilitate mass spectrometric analysis of analytes comprised in the effluent form a gas chromatograph. Ionization may be effected by atmospheric pressure chemical ionization or by atmospheric pressure photo ionization. | 11-03-2011 |
20110266434 | Stacked-Electrode Peptide-Fragmentation Device - A chemical processing apparatus includes a fragmentation device that includes a linear set of stacked electrodes and a voltage control module that forms DC potential wells of opposite polarity for mutual confinement of opposite polarity ions. A method of protein analysis includes confining positive peptide ions and negatively charged reagent anions in, respectively, first and second DC potential wells in a fragmentation device, mixing the ions, in the fragmentation device, and analyzing ion fragments formed in the mixture. | 11-03-2011 |
20110266435 | Ion Guide Array - An ion guide array is disclosed comprising a first ion guide section ( | 11-03-2011 |
20110272571 | LASER-INDUCED ACOUSTIC DESORPTION / ATMOSPHERIC PRESSURE CHEMICAL IONIZATION OF COMPOUNDS - The present disclosure provides a novel system and method for evaporating and ionizing compounds comprising an LIAD source and an ionization source that operates at atmospheric pressure. This system is readily adaptable for use with most commercially available mass spectrometers. Ionization sources include Atmospheric Pressure Chemical Ionization sources (APCI) and Atmospheric Pressure Photo Ionization (APPI) sources. The ionization sources are positioned such that the analyte desorbing from the surface of the LIAD is fed into the ion stream produced by the ionization source and ionized analyte and ionized fragments of the analyte are fed into the sample inlet of a mass spectrometer. These systems allow for the mass spectrometric analysis of non-polar compounds that lack readily ionizable functional groups, such as saturated and unsaturated hydrocarbons and compounds with medium to low polarity, as well as hydrocarbon mixtures, such as petroleum. | 11-10-2011 |
20110272572 | Three-Dimensional Molecular Imaging By Infrared Laser Ablation Electrospray Ionization Mass Spectrometry - The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI). | 11-10-2011 |
20110272573 | ACQUISITION TECHNIQUE FOR MALDI TIME-OF-FLIGHT MASS SPECTRA - The invention relates to acquisition techniques for time-of-flight mass spectra with ionization of the analyte substances by matrix assisted laser desorption. Generally speaking, these acquisition techniques involve adding together a large number of individual time-of-flight spectra, each with restricted dynamic measuring range, to form a sum spectrum. The invention provides a method that improves, in particular, the reproducibility, the concentration accuracy and therefore the ability to quantify the mass spectra. Particular embodiments also increase the dynamic range of measurement. For this purpose, multiple series of mass spectra are acquired, whereby the energy density in the laser spot is increased in discrete steps. As a result, many ion signals saturate the detector and can therefore no longer be evaluated. However, it is possible to employ a technique in which the ion beam is increasingly defocused, or, secondly, to replace parts of the spectrum that are subject to saturation by intensity extrapolations from mass spectra acquired with lower energy density. In the first case, hundreds or thousands of individual mass spectra must be added together in order to increase the dynamic measuring range. In the second case, the finally acquired mass spectrum, with its replacements, forms a mass spectrum with a high dynamic measuring range, improved reproducibility and better concentration accuracy. The gradient of the increasing intensities of the ion signals, as a function of the energy density, supplies additional information about the proton affinity of the analyte ions. The concentration accuracy is enhanced because the increase in the number of proton donors in the ionization plasma leads to an increase in the ionization of those analyte substances that have a lower proton affinity. | 11-10-2011 |
20110278446 | Method of Detecting Filter Extractables in Biopharmaceutical Products By Liquid Chromatography-Mass Spectrometry. - The invention uses liquid chromatography-mass spectrometry to verify the presence or absence of the extractables introduced into a biopharmaceutical product during manufacture, filtration or storage at above a certain concentration. The method disclosed herein can be used to detect the presence of extractables in the actual biopharmaceutical product rather than a surrogate solvent system. Detection of the extractables in the actual drug product provides an accurate description of the leachables profile likely to be introduced to the human or animal patient. In one embodiment, the extractable are introduced by filtration of the bio-pharmaceutical product. | 11-17-2011 |
20110278447 | PHOTOEMISSION INDUCED ELECTRON IONIZATION - A monitor that can detect at least one molecule. The monitor includes a housing with a passage that can receive a sample, and a photocathode that is located within the housing. The monitor also includes a first ultraviolet light source that can direct ultraviolet light onto the photocathode to create electrons that ionize molecules within the sample, and a detector that is coupled to the housing to detect at least one ionized molecule. The monitor enables electron ionization (EI) of a sample for chemical analysis without the disadvantages of current methods that use a hot filament or other thermal cathode devices. | 11-17-2011 |
20110278448 | Devices, Systems, and Methods for Dispersive Energy Imaging - Devices, systems, and methods for dispersive energy imaging are disclosed. The full three-dimensional velocity distribution function of a flowing particle stream may be measured and properties of the particle stream characterized. In some devices, an aperture system controls the entry of a stream of particles into the sensor where an electrostatic deflector separates the stream of particles into different species, and a detector system senses the separated species. | 11-17-2011 |
20110278449 | METHOD FOR IDENTIFYING IN PARTICULAR UNKNOWN SUBSTANCES BY MASS SPECTROMETRY - In order to use the mass spectrometrical analysis at the same time to determine the structure and/or families and/or the chemical properties of a substance, free of subjective evaluation, in the shortest amount of time, in an automatable fashion and with high accuracy, without requiring identical fragmentation patterns and/or defined comparison or identification rules, according to the invention a fragmentation graph is formed from one or more mass spectrometrical fragmentation spectra of to the substance, the data of the graph being compared to reference data preferably stored in an electronic database. The invention is used in particular in biological, pharmaceutical and chemical applications for determining the structure and/or the family and/or the chemical properties of unknown substances. | 11-17-2011 |
20110284733 | MASS SPECTROMETER AND METHODS FOR DETECTING LARGE BIOMOLECULES - A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP. | 11-24-2011 |
20110284734 | Ion Mobility Spectrometer - An ion mobility spectrometer ( | 11-24-2011 |
20110284735 | SYSTEM AND METHOD FOR EXTRACTING A SAMPLE FROM A SURFACE - A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface. | 11-24-2011 |
20110284736 | Data Acquisition System for a Spectrometer Using an Ion Statistics Filter and/or a Peak Histogram Filtering Circuit - A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The spectra processing module generates spectra from the processed signals and supplies the generated spectra to an external processor for post-processing. The spectra processing module may include an ion statistics filter and/or a peak histogram filtering circuit. | 11-24-2011 |
20110284737 | ION TRAP - An ion trap comprises substantially elongate electrodes | 11-24-2011 |
20110290993 | Process for rapidly finding the accurate masses of subfragments comprising an unknown compound from the accurate-mass mass spectral data of the unknown compound obtained on a mass spectrometer - The invention is a process for finding the accurate masses of subfragments comprising an unknown compound from the accurate-mass mass spectral data of the unknown compound obtained on a mass spectrometer. This process generates these accurate masses of subfragments using mass differences of fragment ions and a listing of plausible masses. In this way, the accurate masses of subfragments, useful for generating modular structures, can be obtained very rapidly. | 12-01-2011 |
20110290994 | Methods And Apparatus For Performing Gas And Liquid Mass Spectrometry - Embodiments of the present invention feature devices and methods for performing gas chromatography and liquid chromatography with mass spectrometry. The device and method feature a removable housing which housing contains the gas samples when the mass spectrometry receives gas samples. The device fits an atmospheric pressure ionization housing and upon removal, the atmospheric pressure ionization housing receives liquid samples. | 12-01-2011 |
20110290995 | APPARATUS AND METHOD FOR TRAPPING CHARGED PARTICLES AND PERFORMING CONTROLLED INTERACTIONS BETWEEN THEM - An apparatus and a method for trapping charged particles and performing controlled interactions between them are provided. The apparatus includes a substrate and RF electrodes and dedicated DC electrodes arranged on the substrate and configured to generate a trapping potential for trapping the charged particles above the substrate. The RF and dedicated DC electrodes include at least one RF trapping electrode configured to be driven with an RF voltage for contributing to the trapping potential, an array of two or more trapping site DC electrodes configured to be biased with a DC voltage for contributing to the trapping potential, and a first individually drivable RF control electrode arranged between a first pair out of the two or more trapping site DC electrodes. The first RF control electrode is configured to be individually driven by an adjustable RF voltage such that the trapping potential above and between the first pair of trapping site DC electrodes forms separate charged particle traps adapted for trapping charged particles therein if the adjustable RF voltage takes a first value, and forms a charged particle interaction trap adapted for performing controlled interactions between charged particles if the adjustable RF voltage takes a second value. | 12-01-2011 |
20110290996 | Device and Method for Diluting a Sample - The present invention provides a pump device | 12-01-2011 |
20110290997 | METHOD FOR MARKING LIQUID HYDROCARBONS AND OTHER FUELS AND OILS - A method for marking a petroleum hydrocarbon, biodiesel fuel or ethanol fuel by adding to the petroleum hydrocarbon, biodiesel fuel or ethanol fuel at least one compound having formula (I) | 12-01-2011 |
20110290998 | TUNED SYNTHETIC DENDRIMER CALIBRANTS FOR MASS SPECTROMETRY - Provided are monodisperse synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures. The latter characteristic enables parallel preparation of higher molecular weight compounds displaying useful distributions of discrete molecular weights, thereby providing multi-point mass spectrometry calibration standards. Methods of making and using said calibrants are also provided. | 12-01-2011 |
20110290999 | MONOLITHIC COLUMN CHROMATOGRAPHY - Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of other substances by applying the mixture to the column, reversing the flow through the column to elute the analyte, which is applied to an analytical column provided in-line with the preparative column. In other aspects, a single monolithic column is used to perform both the preparative chromatography and analytical chromatography steps in succession. In another aspect, a chromatography system is provided to perform preparative and analytical chromatography using a single monolithic column. | 12-01-2011 |
20110291000 | Ion Mobility Spectrometer Comprising Two Drift Chambers - An ion mobility spectrometer has two drift chambers and a common, doped reaction region. Each drift chamber includes an ion modifier, such as one that fragments the doped ions by a high electrical field. One of the drift chambers is doped and the other is undoped. In this way, the dopant adducts are removed by the modification process but then recombine with dopant only in the doped chamber so that different outputs are produced by the two drift chambers. | 12-01-2011 |
20110297820 | PSEUDACYCLIN AND METHOD OF INDICATION OF A FUNGUS PSEUDALLESCHERIA BOYDII - Pseudacyclin and method of indication of a fungus | 12-08-2011 |
20110297821 | ION MOBILITY SPECTROMETER DETECTION METHOD USING DOPANTS - Disclosed is an ion mobility spectrometer (IMS) detection method using dopants. The ion mobility spectrometer comprises a sample feeding device, a drift tube and a gas passage system communicated therewith. The gas passage system comprises a pump, a filtering device, a gas inlet and a gas outlet provided on the drift tube for providing clean gas used as the drift gas and the sample carrier gas. The detection method comprises: providing a sampling substrate for sample collection; combining the dopants with the sampling substrate; collecting the sample using the sampling substrate combined with the dopants; and introducing the sampling substrate that has collected the sample into the sample feeding port of the ion mobility spectrometer for detection. With this method, it is unnecessary to provide an independent dopant gas passage, thereby simplifying the structure of the instrument and meanwhile, making it easier and more accurate to control the amount of the dopants required for detection. | 12-08-2011 |
20110297822 | METHODS AND INTERFACES FOR SINGLE AND MULTIDIMENSIONAL SEPARATIONS FOR CHARACTERIZATION AND/OR IDENTIFICATION OF MOLECULES BY MASS SPECTROMETRY - The present invention relates a use of the electrocapture-based separation technology combined with mass spectrometrical fragmentation methods, e.g. sequence of polypeptides by collision-induce dissociation mass spectrometry, for the identification and/or characterization molecules of interest. It also relates the combination of the electrocapture-base separation technology with other liquid separation methods, as e.g. liquid chromatography, in order to achieve multi-dimensional separations prior mass spectrometrical analysis. In addition, it relates physical interfaces between electrocapture-based separations and different types mass spectrometers for on-line or off-line analysis, as well as the coupling of electrocapture-based separations, liquid chromatography and different types of mass spectrometrometers. | 12-08-2011 |
20110297823 | MASS SPECTROMETRY DATA ACQUISITION MODE FOR OBTAINING MORE RELIABLE PROTEIN QUANTITATION - Described herein are methods and systems which enable a unique platform for analyte quantitation. The methods and systems relate to determining the amount of interference in a precursor ion isolation window resulting from an impurity. Once the level of impurity is determined, several methods can be employed to reduce the amount of interference in a subsequent MS/MS spectrum. The methods and systems described herein enable increased quantitation accuracy while maintaining high levels of throughput. | 12-08-2011 |
20110297824 | SYSTEMS AND METHODS INVOLVING DATA PATTERNS SUCH AS SPECTRAL BIOMARKERS - The present invention is generally related to the separation, fractionation, and/or characterization of molecules and/or biomolecules in one or more mixtures. After fractionation, different phases of a partitioning system can be analyzed via an analytical technique such as spectral analysis, chromatography, or the like, to produce a spectrum or other symbolic representation of the species after fractionation, and the spectra of the various fractions/phases compared to define a comparative spectrum as a marker or otherwise providing information about the sample, including such information that is independent of the original level of abundance of the molecules in the mixture. Comparative spectra of various samples can be compared to each other and/or to controls or reference spectra and/or comparative spectra to determine a variety of information. In some embodiments, the methods can be used for discovering and/or identifying patterns in a mixture of species and/or corresponding patterns of species in a second mixture, where each mixture of species originates from biological systems with different physiological conditions as markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening. | 12-08-2011 |
20110303837 | Compact Aerosol Time-Of-Flight Mass Spectrometer - Among other things, methods, systems, apparatus for performing on-the-fly apportionment are described. In particular, a mass spectrometry apparatus includes an ionization laser to produce a deionization laser beam. The apparatus also includes a particle beam path that receives aerosol particles and intersects the ionization laser beam at a location where aerosol particles are desorbed and ionized by the laser beam. The apparatus also includes an ion extractor located at or near the ionization location to separate positive ions and negative ions desorbed from the aerosol particles and to direct the positive ions along a first direction of an ion path and the negative ions along a second, opposite direction of the ion path. The apparatus also includes a first reflectron located at a first side of the ion extractor, on the ion path, to reflect the positive ions along a first reflection path that deviates from the ion path. | 12-15-2011 |
20110303838 | Method Of Avoiding Space Charge Saturation Effects In An Ion Trap - A mass spectrometer is provided comprising a first ion trap ( | 12-15-2011 |
20110303839 | AP-ECD METHODS AND APPARATUS FOR MASS SPECTROMETRIC ANALYSIS OF PEPTIDES AND PROTEINS - An in-source atmospheric pressure electron capture dissociation (AP-ECD) method and apparatus for mass spectrometric analysis of peptides and proteins. An electrified sprayer generates a multiply-charged peptide/protein ions from a sample solution, a source of electrons for negative reagents, and a flow of gas for guiding positively charged ions from the electrified sprayer to a downstream reaction region within the guide. The reaction region being at or near atmospheric pressure and substantially free of the electric field from the electrified sprayer. In another embodiment, the method uses electron transfer dissociation (ETD), in the event that anions are substituted for electrons as the negative reagents. Fragment ions exiting the reaction region are subsequently passed into a mass analyzer of a mass spectrometer for mass analysis of the ions. | 12-15-2011 |
20110309243 | Atmospheric Pressure Ion Source for Mass Spectrometry - An apparatus for generating ions includes an Electrospray ionization source configured to provide a spray of charged droplets from a sample solution during operation of the apparatus; an atmospheric pressure chemical ionization (APCI) source including a corona discharge needle configured to produce a corona discharge that further ionizes the spray during operation of the apparatus; and a gas delivery system configured to deliver a gas flow to the corona discharge needle during operation of the apparatus, wherein the gas flow comprises a reagent ion gas which facilitates ionization of the spray by the corona discharge. | 12-22-2011 |
20110315866 | Forward and Reverse Scanning for a Beam Instrument - A quadrupole mass spectrometer alternates between increasing mass and decreasing mass scans for the purpose of decreasing inter-scan delays. By alternating increasing and decreasing mass scans, the next scan starts where the last scan ended reducing the settling time required. Backsteps may be eliminated by scanning the RF and DC non-linearly. | 12-29-2011 |
20110315867 | SPATIAL SEGREGATION OF PLASMA COMPONENTS - A closed plasma channel (“CPC”) superconductor which, in a first embodiment, is comprised of an elongated, close-ended vacuum conduit comprising a cylindrical wall having a longitudinal axis and defining a transmission space for containing an ionized gas of vapor plasma (hereinafter “plasma components”), the plasma components being substantially separated into regionalized channels parallel to the longitudinal axis in response to a static magnetic field produced within the transmission space. Each channel is established along the entire length of the transmission space. At least one channel is established comprised primarily of free-electrons which provide a path of least resistance for the transmission of energy therethrough. Ionization is established and maintained by the photoelectric effect of a light source of suitable wavelength to produce the most conductive electrical transmission medium. Various embodiments of the subject method and apparatus are described including a hybrid system for the transmission of alternating current or, alternatively, multi-pole EM fields through the cylindrical wall and direct current or charged particles through the stratified channels. | 12-29-2011 |
20110315868 | MASS SPECTROMETRIC SYSTEM - A mass spectrometric device of the present invention includes a quadrupole filter ( | 12-29-2011 |
20110315869 | MASS SPECTROMETER - An object of the present invention is to provide means for solving troubles. Examples of the troubles include sensitivity degradation and resolution degradation of a mass spectrometer, which are caused by an axis deviation of a component, particularly at least one orifice located between an ion source and a detector, to decrease the number of ions reaching the detector, and a variation in performance caused by exchange of components such as the orifice. | 12-29-2011 |
20110315870 | SYSTEMS AND METHODS FOR ANALYZING SUBSTANCES USING A MASS SPECTROMETER - Systems and methods for analyzing compounds in a sample. In one embodiment, the present technology is directed towards a method of analyzing a sample, comprising: emitting ions from the sample; selectively filtering the emitted ions for at least one designated trigger ion; fragmenting the designated trigger ions; scanning for a designated trigger ion fragment; and upon detecting the designated trigger ion fragment, scanning for at least one confirmatory ion fragment. | 12-29-2011 |
20110315871 | METHOD OF FORMING MASS IMAGE - An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. | 12-29-2011 |
20120001065 | EVALUATING RENAL FUNCTION - This document relates to methods and materials involved in evaluating renal function in a subject. For example, methods and materials for evaluating renal clearance using mass spectrometry techniques are provided. | 01-05-2012 |
20120006983 | METHOD OF SURFACE IONIZATION WITH SOLVENT SPRAY AND EXCITED-STATE NEUTRALS - A method of producing analyte, analyte fragment, and/or analyte adduct ions for mass analysis comprises the steps of spraying a solvent at a surface bearing the analyte, directing desorbed analyte evolved from the surface into a region containing species which will ionize the analyte on collision, the ionizing region not including the surface bearing the analyte, and directing the ions formed in the ionizing region to the entrance to a mass analyzer. | 01-12-2012 |
20120018628 | MATRIX FOR REAL-TIME AEROSOL MASS SPECTROMETRY OF ATMOSPHERIC AEROSOLS AND REAL-TIME AEROSOL MALDI MS METHOD - Matrix for real-time aerosol mass spectrometry of atmospheric aerosols and real-time aerosol MALDI MS method Abstract The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass spectrometry method, in particular an aerosol MALDI mass spectrometry method, to the use of a specific compound as a MALDI matrix material, and to the use of a MALDI matrix composition in a gas phase coating method. The matrix material of the invention comprises a 2-mercapto-4,5-dialkylthiazole according to formula (I), wherein X is chosen from S, O or N, and wherein R | 01-26-2012 |
20120018629 | MECHANICAL HOLDER FOR SURFACE ANALYSIS - A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein. | 01-26-2012 |
20120018630 | Nonoparticulate Assisted Nanoscale Molecular Imaging by Mass Spectrometery - Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source. | 01-26-2012 |
20120018631 | ION-MOBILITY ANALYSER - An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes | 01-26-2012 |
20120025067 | MASS SPECTROMETRIC DETERMINATION OF NON-DERIVATIZED, NON-METABOLIZED VITAMIN D - The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry. | 02-02-2012 |
20120025068 | Mass Spectrometry - Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) apparatus and method comprising a laser and a multimode optical fiber to deliver a laser beam to a MADLI ion source. A vibration coupling is provided at a region along the length of optical fiber to impart an oscillatory vibrational motion at the optical fibre to move the irradiation intensity maxima at the sample to increase the effective irradiation surface area. The present apparatus and method provide increased imaging sensitivity and a corresponding reduction in data acquisition times. | 02-02-2012 |
20120025069 | Laser Ablation Electrospray Ionization (LAESI) for Atmospheric Pressure, In Vivo, and Imaging Mass Spectrometry - The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI) | 02-02-2012 |
20120032071 | MULTI-MODAL PARTICLE DETECTOR - Systems, methods and computer program products for the multi-modal detection of particles are described herein. An embodiment of the present invention is a particle detector that includes a first chamber wherein analyte particles are subjected to a first particle detection mechanism, and a second chamber coupled to the first chamber, wherein the analyte particles are subjected to a second particle detection mechanism, and wherein the detection characteristics of second particle detection mechanism are orthogonal to detection characteristics of the first particle detection mechanism. According to another embodiment, the present invention is a particle detection method including the steps of detecting presence of at least one predetermined particle type in an analyte particle sample using a first particle detection mechanism, and confirming the presence of the predetermined particle type in the analyte particle sample using a second particle detection mechanism, wherein detection characteristics of the second particle detection mechanism are orthogonal to detection characteristics of the first detection mechanism. | 02-09-2012 |
20120032072 | Method and Apparatus for Automatic Estimation of Detector Gain in a Mass Spectrometer - A method and apparatus involve: performing a plurality of analytical scans during normal operation of a mass spectrometer having a detection section, wherein data is generated during the analytical scans in a manner that includes use of the detection section; and automatically evaluating the data from the analytical scans to monitor whether an actual gain of the detection section changes over time. | 02-09-2012 |
20120032073 | RAPID GAS-PHASE ISOTOPIC LABELING FOR ENHANCED DETECTION OF PROTEIN CONFORMATIONS - A mass spectrometer (MS) that is adapted to allow rapid gas-phase hydrogen/deuterium exchange (HDX) labeling of ions in one or more traveling wave ion guides (TWIGs) with or without ion mobility separation. The addition of isotopic labeling by gas-phase HDX offers a sensitive alternative dimension for conformational detection, which enables high resolution detection of gaseous conformations based on shape and surface reactivity. Gas-phase, isotopic HDX labeling or “curtain” labeling, can be performed by infusing a reactive, isotopic labeling gas, e.g., ND | 02-09-2012 |
20120037795 | METHOD AND APPARATUSES FOR QUALITY EVALUATION AND LEAK TESTING - It is suggested to use mass spectroscopy in in-line testing of closed containers. | 02-16-2012 |
20120037796 | METHOD AND APPARATUS FOR LEAK TESTING CONTAINERS - Closed containers which are filled with a consumer product are tested on leakiness by means of mass spectrometry ( | 02-16-2012 |
20120037797 | DESORPTION AND IONIZATION METHOD AND DEVICE - The present invention involves a method and a device for sequentially desorbing and ionizing mixed analytes on a solid surface with a gradual temperature scan, and continuously collecting data for multiple times in the gradual desorption and ionization process. By gradually increase the temperature of at least one part of the sample, the analytes with different thermal desorption capabilities are sequentially desorbed from surfaces of the solid sample, thereby providing a sample pre-separation scheme, so as to reduce difficulties to subsequent mass spectrum detection. Meanwhile, since mass spectrum data of the analytes with different boiling points is collected for multiple times during a temperature scan, the analytes with a low boiling point can be detected first at lower temperature in order to avoid rapid exhaustion at higher temperature, thereby improving the detection efficiency of the analytes with low boiling points. | 02-16-2012 |
20120037798 | PARTICLE-LOADED MEMBRANE FOR SOLID-PHASE-EXTRACTION AND METHOD FOR PERFORMING SALDI-MS ANALYSIS OF AN ANALYTE - A membrane comprising graphitized carbon black (GCB) with dual function for solid-phase extraction and surface-assisted laser desorption mass spectrometry (SPE/SALDI-MS) analysis is disclosed. Devices extraction comprising such membrane and methods utilising such membranes are also disclosed. | 02-16-2012 |
20120043460 | Ion Transfer Tube Having Single or Multiple Elongate Bore Segments and Mass Spectrometer System - An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section. | 02-23-2012 |
20120043461 | KINGDON MASS SPECTROMETER WITH CYLINDRICAL ELECTRODES - The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments. Appropriate voltages at the sheath electrode segments generate a potential distribution between the two concentric cylindrical surfaces which forms a parabolic potential well in the axial direction for orbiting ions. The ion clouds oscillating harmonically in the axial direction in this potential well induce image currents in suitable electrodes, from which the oscillation frequencies can be determined by Fourier analyses. | 02-23-2012 |
20120056084 | Apparatus Comprising an Ion Mobility Spectrometer - A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber. | 03-08-2012 |
20120056085 | ION ANALYSIS APPARATUS AND METHOD OF USE - The present invention is concerned with an ion analysis apparatus for conducting differential ion mobility analysis and mass analysis. In embodiments, the apparatus comprises a differential ion mobility device in a vacuum enclosure of a mass spectrometer, located prior to the mass analyser, wherein the pumping system of the apparatus is configure to provide an operating pressure of 0.005 kPa to 40 kPa for the differential ion mobility device, and wherein the apparatus includes a digital asymmetric waveform generator that provides a waveform of frequency of 50 kHz to 25 MHz. Examples demonstrate excellent resolving power and ion transmission. The ion mobility device can be a multipole, for example a 12-pole and radial ion focusing can be achieved by applying a quadrupole field to the device in addition to a dipole field. | 03-08-2012 |
20120061561 | APPARATUS AND METHOD FOR ELEMENTAL ANALYSIS OF PARTICLES BY MASS SPECTROMETRY - An apparatus for elemental analysis of particles such as single cells or single beads by mass spectrometry is described. The apparatus includes means for particle introduction; means to vaporize, atomize and ionize elements associated with a particle; means to separate the ions according to their mass-to-charge ratio; means to detect the separated ions, means to digitize the output of the means to detect the ions; means to transfer and/or to process and/or record the data output of the means to digitize, having means to detect the presence of a particle in a mass spectrometer; and means to synchronize one of the means for ion detection, data digitization, transfer, processing and recording with the means to detect the presence of a particle. Methods and computer readable code implementing aspects of the apparatus, and for reducing the rates of data generation, digitization, transfer, processing and recording are also described. | 03-15-2012 |
20120061562 | METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydrorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay. | 03-15-2012 |
20120061563 | ION MOBILITY SPECTROMETER - This invention refers to an ion mobility spectrometer in a fluid subjected to an electric field and an acoustic wave for the selective detection, classification and quantitative determination of the concentration of charged particles, based on their electrical mobility. The functioning of this device is based on the application of an electric field in a classification region occupied by a fluid. The electric field provokes drift of the charged particles through the classification region. The drifting particles suffer a lateral perturbation in their trajectory due to an oscillatory movement of the fluid in which they are immersed when this is subjected to an acoustic wave. Both the spectrometer and the method of discrimination and detection of the current of charged particles is the object of this invention. | 03-15-2012 |
20120068061 | CHEMICAL DETECTION SYSTEM AND METHOD - The exemplary embodiments provide a method, system, and device for identifying chemical species in a sample. According to one embodiment, the method, system, and device may include introducing a sample gas into a differential ion mobility device, ionizing at least a portion of the sample gas to generate at least one ion species, filtering the at least one ion species between a pair of filter electrodes, generating a detection signal in response to the at least one ion species depositing a charge on a collector electrode, and detecting a spectral peak associated with the at least one ion species. | 03-22-2012 |
20120068062 | Method and Apparatus for Tandem Time-of-Flight Mass Spectrometry - Tandem time-of-flight mass spectrometry method and apparatus permits an ion gate to be time set optimally at all times if the instrumental conditions are modified. Delayed extraction conditions for the mass-to-charge ratios of plural reference substances and optimum values of the time for which the ion gate is opened are measured and stored in a data table. Delayed extraction conditions and opening time of the ion gate which optimize the mass resolution at the mass-to-charge ratio of the desired precursor ions are found based on values stored in the table. | 03-22-2012 |
20120068063 | Direct Atmospheric Pressure Sample Analyzing System - A system, method and apparatus for injecting reactive species and ions from an ambient plasma ionization source into an atmospheric pressure ion mobility spectrometer. | 03-22-2012 |
20120074306 | SPATIALLY RESOLVED THERMAL DESORPTION/IONIZATION COUPLED WITH MASS SPECTROMETRY - A system and method for sub-micron analysis of a chemical composition of a specimen are described. The method includes providing a specimen for evaluation and a thermal desorption probe, thermally desorbing an analyte from a target site of said specimen using the thermally active tip to form a gaseous analyte, ionizing the gaseous analyte to form an ionized analyte, and analyzing a chemical composition of the ionized analyte. The thermally desorbing step can include heating said thermally active tip to above 200° C., and positioning the target site and the thermally active tip such that the heating step forms the gaseous analyte. The thermal desorption probe can include a thermally active tip extending from a cantilever body and an apex of the thermally active tip can have a radius of 250 nm or less; | 03-29-2012 |
20120074307 | METHOD AND DEVICE FOR CARRYING OUT A QUANTITATIVE SPATIALLY-RESOLVED LOCAL AND DISTRIBUITION ANALYSIS OF CHEMICAL ELEMENTS AND IN SITU CHARACTERIZATION OF THE ABLATED SURFACE REGIONS - A laser ablation chamber, which is suitable for use in a conventional laser-assisted micro dissection unit (LMD), in combination with the LMD allows for both quantitative spatially resolved nanolocal analysis and distribution analysis of element concentrations of a sample, and a microscopic detection of the surface topography of the same sample, in the nanometer range. Optionally, further examinations may follow, without having to remove the sample from a microscope slide bearing the sample. For the examination, a region of the sample to be analyzed is selected with the aid of a microscope of a LMD. For this purpose, the sample is located on the lower face of a cover slip (microscope slide), which also forms part of a laser ablation chamber mounted beneath the microscope slide and inside the LMD. A portion of the sample is ablated and analyzed. Optionally, the existing LMD instrumentation may be used to deliberately cut out certain regions of the tissue in which metals were detected for further analytics and to collect these regions in sample containers, which are mounted beneath the microscope slide after the laser ablation. | 03-29-2012 |
20120074308 | IMMUNOSUPPRESSANT MONITORING BY MALDI MASS SPECTROMETRY - The invention relates to therapeutic drug monitoring (TDM) by mass spectrometry, particularly to the monitoring of immunosuppressant levels in blood of patients with transplanted organs. A liquid phase extraction procedure reproducibly extracts the therapeutic drug molecules from whole blood and mass spectrometric analysis on MALDI instruments, with a matrix substance for highest sensitivity and special sample deposition procedure for a reproducible ionization of the therapeutic drug molecules. Suitable internal standard substances added to the blood in exact amounts ensure a correct absolute quantification. The method is particularly suitable for immunosuppressants belonging to the class of macrocyclic lactones (sirolimus, tacrolimus, everolimus) and cyclic polypeptides (cyclosporin A), and even works as a multiplex method for all four immunosuppressants simultaneously. | 03-29-2012 |
20120074309 | INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY APPARATUS AND MEASURED DATA PROCESSING METHOD IN THE INDUCTIVELY COUPLED PLASMA MASS SPECTROSCOPY APPARATUS - The present invention performs measurement for determining a P/A coefficient and/or determination of the P/A coefficient after measurement of a standard density sample for density calibration in an ICP-MS. Specifically, after measuring signal intensity of each mass number in the standard density sample, the P/A coefficient is determined from the signal intensity for a mass number having the signal intensity within a P/A coefficient calibration range, while for a mass number having the signal intensity above the calibration range, a voltage applied to an ion lens of the ICP-MS is changed so that the signal intensity becomes within the calibration range, to thereby adjust an ion transmission ratio of the ion lens, and then the P/A coefficient is determined from the signal intensity determined within the calibration range. | 03-29-2012 |
20120074310 | Monitoring treatment of colorectal cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment. | 03-29-2012 |
20120074311 | Monitoring treatment of Head and Neck cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer patient, head and neck squamous cell carcinoma or colorectal cancer patient has likely developed a non-responsiveness to treatment with a drug targeting an epidermal growth factor receptor pathway. As the methods of this disclosure require only simple blood samples, the methods enable a fast and non-intrusive way of measuring when drugs targeting the EGFR pathway cease to be effective in certain patients. This discovery represents the first known example of true personalized selection of these types of cancer patients for treatment using these classes of drugs not only initially, but during the course of treatment. | 03-29-2012 |
20120074312 | METHOD FOR QUANTIFYING RED PHOSPHOROUS IN RESIN - The invention offers a method of quantitatively analyzing red phosphorus in a resin by the pyrolysis GCMS, the method having a further improved quantification accuracy. The method has the following steps: determining the retention time A of red phosphorus by performing pyrolysis GCMS measurement under a predetermined separating condition; determining the peak strength ratio B of the specimen to be measured by performing pyrolysis GCMS measurement to confirm that a peak of a mass spectrum is detected at the same retention time as the retention time A and by dividing the measured value of the peak area by the quantity of the specimen; confirming that when the height of the peak at an m/z of 124 in the mass spectrum is taken as 10, the height of the peak at an m/z of 62 lies in the 1.82-2.06 range and the height of the peak at an m/z of 93 lies in the 1.03-1.15 range; determining the relationship between the peak strength ratio C and the red-phosphorus content using multiple reference specimens under the same separating condition; and determining the quantity of the red phosphorus in the specimen to be measured by comparing the peak strength ratio B with the foregoing relationship. | 03-29-2012 |
20120080589 | SYSTEM AND METHOD FOR LASER ASSISTED SAMPLE TRANSFER TO SOLUTION FOR CHEMICAL ANALYSIS - A system and method for laser desorption of an analyte from a specimen and capturing of the analyte in a suspended solvent to form a testing solution are described. The method can include providing a specimen supported by a desorption region of a specimen stage and desorbing an analyte from a target site of the specimen with a laser beam centered at a radiation wavelength (λ). The desorption region is transparent to the radiation wavelength (λ) and the sampling probe and a laser source emitting the laser beam are on opposite sides of a primary surface of the specimen stage. The system can also be arranged where the laser source and the sampling probe are on the same side of a primary surface of the specimen stage. The testing solution can then be analyzed using an analytical instrument or undergo further processing. | 04-05-2012 |
20120080590 | METHODS OF DETERMINING PLANT ZYGOSITY USING MASS SPECTROMETRY - The present invention relates to methods and systems for identifying seeds that are homozygous for an allele of interest and/or for identifying seeds that are likely to produce plants possessing a desired trait. Methods of producing plants that are homozygous for an allele of interest and/or that possess a desired trait are also provided. | 04-05-2012 |
20120080591 | Method for Sequencing RNA by In-source Decay Using Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometer - An analytic method is provided for obtaining much sequence information by causing in-source decay of modified RNA and non-modified RNA and generating many fragment ions. Particularly, a method for analysis wherein a matrix that efficiently causes decomposition by in-source decay of RNA of 20 bases or longer is used in an apparatus that has a laser of a wavelength commonly used in MALDI-TOF MS. A specimen containing RNA is subjected to matrix assisted laser desorption ionization time of flight mass spectrometry that uses 2,4-dihydroxyacetophenone as a matrix to obtain fragment ions derived from the RNA. The difference in mass between the peaks of ions in the fragment ions is used to analyze the sequence of the RNA. | 04-05-2012 |
20120080592 | METHOD AND SYSTEM FOR SURFACE SAMPLING - A system and sampling probe adaptable to an ultrasonic surgical instrument applies irrigation fluid and ultrasonic or vibrational energy to a target, and aspirates material desorbed from the target into a pick-up conduit. A suction source at the distal end of the conduit may aspirate the material released from the target with the irrigation fluid, thus efficiently sampling a broad range of materials from an arbitrary target to produce an analyzable effluent analyte stream which may be ionized and provided to the inlet of an ion-type analysis instrument, or may be fed directly to an instrument such as a flow cytometer, IR or fluorescence spectrophotometer, or other analyzer. Carrier gas may be provided to more effectively transport the desorbed material, and the probe may be incorporated into a robotic device to automatically carry out surface imaging or to effect sampling in hazardous environments. | 04-05-2012 |
20120080593 | Cyclone Separator Type Mass Analyzing System - Provided is a small-sized mass analysis system capable of analyzing an analysis target system being under atmospheric pressure. The mass analysis system ( | 04-05-2012 |
20120085900 | NANOMANIPULATION COUPLED NANOSPRAY MASS SPECTROMETRY (NMS) - A coupled nanomanipulation and nanospray mass spectrometry (NMS) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a NMS. The bio-workstation primarily comprises of a nanomanipulator stage with a plurality of nano-positioners attached to a cabinet with a piezo voltage source and a pressure injector. The present invention further describes a fingerprint lift method that when coupled with the system disclosed herein can be used for retrieval and analysis of trace amounts of drug and explosive residues. The system described herein has been used in the areas of trace and document analysis within the forensic field, trace fiber analysis, and electrostatic lifts for illicit drugs, as well as document and painting analysis. | 04-12-2012 |
20120085901 | Time Of Flight Acquisition System - A Time of Flight Acquisition system is disclosed wherein a digitiser ( | 04-12-2012 |
20120085902 | METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay. | 04-12-2012 |
20120085903 | MASS SPECTOMETRY USING LASERSPRAY IONIZATION - Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over | 04-12-2012 |
20120085904 | MASS SPECTROMETER AND METHOD FOR ISOTOPE ANALYSIS - A mass spectrometer for analyzing isotopic signatures, with at least one magnetic analyzer and optionally with an electric analyzer as well, with a first arrangement of ion detectors and/or ion passages and, arranged downstream thereof in the direction of the ion beam, a second arrangement of ion detectors, with at least one deflector in the region of the two arrangements of ion detectors or between these arrangements. Additionally, a multi-collector arrangement, special uses and a method for analyzing isotopes in a sample. The mass spectrometer according to the invention has a control for the at least one deflector such that ion beams of different isotopes can be routed to at least one ion detector in the second arrangement. | 04-12-2012 |
20120091330 | METHOD TO PERFORM BEAM-TYPE COLLISION-ACTIVATED DISSOCIATION IN THE PRE-EXISTING ION INJECTION PATHWAY OF A MASS SPECTROMETER - Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. Following injection and selection of a particular ion type or population, that population can be fragmented using the pre-existing ion injection pathway or inlet of a mass spectrometer. This is achieved by transmitting the ions back along the ion injection pathway. As the ions pass into the higher pressure regions located in or near the atmospheric pressure inlet, the ions are fragmented and then trapped. Following fragmentation and trapping, the ions can either be re-injected into the primary ion selection device or sent on to a secondary mass analyzer. | 04-19-2012 |
20120091331 | MULTIMODE CELLS AND METHODS OF USING THEM - A mass spectrometer is provided that is configurable for operation in both a Kinetic Energy Discrimination (KED) mode and a dynamic reaction cell (DRC) mode. To operate in the KED mode, a collision cell can be filled with a quantity of the inert gas, and an energy barrier can be formed between the collision cell and a downstream mass analyzer. To operate instead in the mode, the collision cell can be filled with a quantity of gas that is reactive with the interferer ions. | 04-19-2012 |
20120091332 | Charged Particle Analysers and Methods of Separating Charged Particles - A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyser; and separating the charged particles according to their flight time. An analyser for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam. An array of arcuate focusing lenses may be used which are located at substantially the same z coordinate, the arcuate focusing lenses in the array being spaced apart in the arcuate direction and the array extending at least partially around the z axis, thereby constraining the arcuate divergence of the beam a plurality of times as it flies through the analyser. | 04-19-2012 |
20120091333 | DIAGNOSTIC METHOD - The present invention relates to methods to identify one or more conditions in a subject. In particular, it relates to methods of identifying a condition such as cancer, which changes a lipid profile in a keratin-containing component of a subject, the changes to the lipid profile being determined by techniques such as chromatography and mass spectrometry. | 04-19-2012 |
20120104243 | Silver and Silver Nanoparticle MALDI Matrix Utilizing Online Soft Landing Ion Mobillity - Silver nanoparticles as a sample matrix for Matrix Assisted Laser Desorption Ionization (MALDI) along with a novel method for nanoparticle development is described herein. The silver nanoparticles were generated from silver ions on the surface of a MALDI plate utilizing a Soft Landing Ion Mobility (SLIM) instrument. Upon interaction with the surface the incident silver ions were labile and aggregated into the nanoparticle structures in a time dependent fashion. Post landing analyses were completed by Time of Flight mass spectrometry (TOF), and of particular interest in the spectra were the elimination of low mass interference peaks that generally plague organic based matrices. The approach of the present invention significantly decreases sample preparation time and may lead to a preparation free MALDI source by soft landing a matrix directly on the sample surface. | 05-03-2012 |
20120104244 | PETROLEUM OIL ANALYSIS USING LIQUID NITROGEN COLD STAGE - LASER ABLATION- ICP MASS SPECTROMETRY - A novel application of a cold-stage coupled to a laser ablation-ICP-MS system is disclosed herein. The novel system of the present invention offers significant advantages over other systems employed for cooling samples prior to LA-ICP-MS analysis. The system discloses herein has multiple applications, including detection of one or more metal contaminants in an oil sample. | 05-03-2012 |
20120112051 | Atmospheric Pressure Charge-Exchange Analyte Ionization - A non-radioactive atmospheric pressure method for ionization of analytes comprises creating an electrical discharge in a carrier gas thus creating metastable neutral excited-state species. The carrier gas is directed at the analytes and the analytes under conditions to suppress protonated water and water clusters. | 05-10-2012 |
20120112052 | DETECTION OF VITAMINS A AND E BY TANDEM MASS SPECTROMETRY - Methods are described for measuring the amount of one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample. | 05-10-2012 |
20120112053 | SALIVA ASSAY TECHNIQUE FOR HEAVY METAL - A method for determining heavy metal loading in a subject includes collecting a saliva sample from the subject containing a concentration of a heavy metal. The saliva sample is subjected to inductively coupled plasma mass spectrometry to yield a heavy metal loading measurement for the subject. The saliva sample is readily collected on a substrate absorbing a preselected amount of saliva such as filter paper. As the amount of saliva necessary to saturate a given volume of substrate is known, the volume of saliva within a substrate is also known. The resulting heavy metal loading measurement is readily correlated with a blood level for the heavy metal in the subject. | 05-10-2012 |
20120112054 | HIGH RESOLUTION EXCITATION/ISOLATION OF IONS IN A LOW PRESSURE LINEAR ION TRAP - Methods for improved separation of ions from an ion trap employing a combination of low pressure and low amplitude ion excitation, including methods for removing, from an ion trap ion population, ions having a m/z value neighboring that of an ion of interest, mass spectrometry methods providing improved resolution of ion detection, and programmable apparatus programmed with instructions therefor. | 05-10-2012 |
20120112055 | Mass Spectrometer - A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound. | 05-10-2012 |
20120112056 | Electrostatic Ion Trap - An ion trap includes an electrode structure, including a first and a second opposed mirror electrodes and a central lens therebetween, that produces an electrostatic potential in which ions are confined to trajectories at natural oscillation frequencies, the confining potential being anharmonic. The ion trap also includes an AC excitation source having an excitation frequency f that excites confined ions at a frequency of about twice the natural oscillation frequency of the ions, the AC excitation frequency source preferably being connected to the central lens. In one embodiment, the ion trap includes a scan control that mass selectively reduces a frequency difference between the AC excitation frequency and about twice the natural oscillation frequency of the ions. | 05-10-2012 |
20120112057 | MEMBRANE FOR HOLDING SAMPLES FOR USE WITH SURFACE IONIZATION TECHNOLOGY - The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection. | 05-10-2012 |
20120112058 | SURFACE COATING FOR LASER DESORPTION IONIZATION MASS SPECTROMETRY OF MOLECULES - The present invention refers to a process for laser desorption ionization mass spectrometry using a polymer of aniline or an aniline derivative, or phenyl acrylate or a phenyl acrylate derivative. The polymer is a UV absorbing polymer onto which polymer a sample probe can be deposited. With the use of a UV laser beam, the sample molecules can be desorbed and ionized. The addition of a UV absorbing matrix material may not be necessary any more. | 05-10-2012 |
20120112059 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - An object is to measure both cations and anions with high duty cycle. In a mass spectrometer comprising an ion source ( | 05-10-2012 |
20120119078 | Ion Population Control Device For A Mass Spectrometer - A mass spectrometer is disclosed wherein an ion beam attenuator is arranged upstream of an ion trap mass analyser. An ion tunnel ion trap comprising an upstream ion accumulation section and a downstream ion accumulation section is arranged upstream of the ion beam attenuator. Ions are released from the ion tunnel ion trap and the intensity of the ion beam which is transmitted to the ion trap analyser is controlled by the ion beam attenuator. The fill time during which ions are admitted into the ion trap mass analyser remains substantially constant and is substantially independent of the intensity of the ion beam. | 05-17-2012 |
20120119079 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-17-2012 |
20120119080 | PREDICTION OF PHENOTYPES AND TRAITS BASED ON THE METABOLOME - The invention provides methods for characterizing metabolic profiles, phenotypic profiles and trait profiles in plants or groups of plants. Additionally, methods for establishing an unbiased model between a phenotypic profile and a metabolic profile, or between a trait profile and metabolic profile, are also provided by the invention. Further, methods for using such unbiased models to accurately predict the development of a phenotype of interest or a trait of interest in an independent, immature plant are also provided. In one embodiment, immature plants are selected for use based on their predicted development of a phenotype or trait of interest. | 05-17-2012 |
20120119081 | INSECT-BASED MODEL FOR PHARMACO-KINETIC STUDIES - There is provided a new methodology for initial assessment of compound PK. The invention is generally particular useful for efficient screening of and assessment of PK profiles of newly synthesized compounds in the early phase of drug discovery. | 05-17-2012 |
20120126107 | Enhanced Sensitivity for Analysis of Carbonyl Containing Compounds Using Mass Spectrometry - The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for detection of a carbonyl group-containing compound by mass spectrometry can comprise derivatizing the carbonyl group-containing compound with an O-substituted hydroxylamine thereby producing an oxime, resulting in enhanced sensitivity of detection by mass spectrometry, as compared to the underivatized carbonyl group-containing compound. | 05-24-2012 |
20120126108 | Dual Source Mass Spectrometry System - A dual source mass spectrometer system ( | 05-24-2012 |
20120126109 | MULTI-DIMENSIONAL ION MOBILITY SPECTROMETRY METHODS AND APPARATUS - Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity. | 05-24-2012 |
20120126110 | Method of Processing Mass Spectral Data - A method of processing mass spectral data is disclosed comprising digitizing a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time T | 05-24-2012 |
20120126111 | METHOD OF EVALUATING CANCER RISK IN HUMAN - Disclosed is a method of providing a risk evaluation and diagnosis of human cancer, by examining the presence, in the volatile fraction of a human saliva sample, of a combination of particulate biochemical volatile organic compounds, which is indicative of an increased risk of developing cancer. | 05-24-2012 |
20120132795 | DIFFERENTIAL MOBILITY SPECTROMETER WITH SPATIAL ION DETECTOR AND METHODS RELATED THERETO - Differential mobility spectrometer with spatial ion detector and methods related thereto are disclosed. The use of one or more spatial detector within differential mobility spectrometry can provide for the identification and separation of ions with similar mobility and mass. | 05-31-2012 |
20120132796 | ELECTROSPRAY IONIZATION MASS SPECTROMETRY METHODOLOGY - A method of enhanced speciation of both positive and negatives species in an analyte is disclosed. The method can include producing a first analyte solution comprising an analyte composition and an effective amount of silver triflate, and analyzing the first analyte solution with an electrospray ionization mass spectrometer. The method can also include producing a second analyte solution comprising a portion of the analyte composition and an effective amount of a compound of formula I, and analyzing the second analyte solution with an electrospray ionization mass spectrometer. The compound of formula I is [NX | 05-31-2012 |
20120132797 | MEANS AND METHODS FOR DIAGNOSING THYROID DISORDERS - The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses. | 05-31-2012 |
20120138783 | ION MOBILITY SPECTROMETER AND METHOD FOR IMPROVING THE DETECTION SENSITIVITY THEREOF - The present invention relates to a method of improving detection sensitivity of an ion mobility spectrometer, comprising: inserting a sample into a sample receiving device of the ion mobility spectrometer; triggering an operation of spectra acquisition through an optocoupler; when the number of the acquired spectra reaches the level required to contain enough information for accurate detection of explosives with relatively high vapor pressure, adding a dopant instantly to the ionization region by controlling the ON/OFF-state of an electromagnetic valve; when the number of the acquired spectra reaches the level required to contain enough information for accurate detection of explosives with relatively low vapor pressure, stopping the acquisition operation, and turning off the electromagnetic valve so as to stop adding the dopant to the ionization region; analyzing all of the acquired spectra to obtain the detection result. The addition time of the dopant is controlled such that the dopant can take effect on the detection of some explosives with relatively low vapor pressure while the explosives which can be detected with higher sensitivity when no dopant is added can be analyzed in the case that the dopant concentration is very low, thereby achieving the optimal detection performance of the apparatus by taking account of its response to various explosives. | 06-07-2012 |
20120138784 | Method for in Vivo Measurement of Reverse Cholesterol Transport - Methods and compositions for the in vivo measurement of reverse cholesterol transport are provided. | 06-07-2012 |
20120138785 | Charged Particle Analysers And Methods Of Separating Charged Particles - Methods and analysers useful for time of flight mass spectrometry are provided. A method of separating charged particles comprises the steps of: providing an analyser comprising two opposing mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner and defining therebetween an analyser volume, the mirrors creating an electrical field within the analyser volume comprising opposing electrical fields along z, the strength along z of the electrical field being a minimum at a plane z=0; causing a beam of charged particles to fly through the analyser, orbiting around the z axis within the analyser volume, reflecting from one mirror to the other at least once thereby defining a maximum turning point within a mirror; the strength along z of the electrical field at the maximum turning point being X and the absolute strength along z of the electrical field being less than |X|/2 for not more than ⅔ of the distance along z between the plane z=0 and the maximum turning point in each mirror; separating the charged particles according to their flight times; and ejecting at least some of the charged particles having a plurality of m/z from the analyser or detecting the at least some of charged particles having a plurality of m/z, the ejecting or detecting being performed after the particles have undergone the same number of orbits around the axis z. | 06-07-2012 |
20120138786 | METHOD OF DETECTING PNEUMOCANDIN COMPOUNDS - The present invention concerns a method of detecting the antifungal cyclic hexapeptides Pneumocandin B | 06-07-2012 |
20120145889 | Reflector Time-of-Flight Mass Spectrometry with Simultaneous Space and Velocity Focusing - A time-of-flight mass spectrometer includes an ion source that generates ions. A two-field ion accelerator accelerates the ions through an ion flight path. A pulsed ion accelerator focuses the ions to a first focal plane where the ion flight time is substantially independent to first order of an initial velocity of the ions prior to acceleration. An ion reflector focuses ions to a second focal plane where the ion flight time is substantially independent to first order of an initial velocity of the ions prior to acceleration. An ion detector positioned at the second focal plane detects the ions. The two-field ion accelerator and the ion reflector cause the ion flight time to the ion detector for the ion of predetermined mass-to-charge ratio to be substantially independent to first order of both the initial position and the initial velocity of the ions prior to acceleration. | 06-14-2012 |
20120145890 | Methods And Systems For Mass Spectrometry - The present invention relates generally to mass spectrometry. The present invention relates more particularly to methods and systems for use in mass spectrometric identification of a variety of analytes, including high molecular weight species such as proteins. One embodiment of the invention is a method for analyzing an analyte. The method includes nebulizing a suspension of the analyte in a solvent with a surface acoustic wave transducer; and performing mass spectrometry on the nebulized suspension. The surface acoustic wave transducer can be used, for example, to transfer non-volatile peptides and proteins (as well as other analyztes, such as oligonucleotides and polymers) to the gas phase at atmospheric pressure. Nebulization using surface acoustic waves can be conducted in a discontinuous or pulsed mode, similar to that used in MALDI, or in a continuous mode, as in ESI. | 06-14-2012 |
20120145891 | Using Plasma Proteomic Pattern For Diagnosis, Classification, Prediction Of Response To Therapy And Clinical Behavior, Stratification Of Therapy, And Monitoring Disease In Hematologic Malignancies - The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies. | 06-14-2012 |
20120145892 | AUXILIARY FREQUENCY PARAMETRIC EXCITATION OF QUADRUPOLE MASS SPECTROMETERS - The apparatus introduces a second adjustable resonant point in a QMS at a frequency that is close to a multiple of the fundamental frequency by adjusting driving point impedance characteristics of the QMS. The apparatus measures the first and second resonant point of the QMS to account for changes in the operational characteristics of the QMS. | 06-14-2012 |
20120153138 | METHODS FOR DETECTING SUBSTANCES IN BIOLOGICAL SAMPLES - Methods for simultaneously detecting multiple drug classes in a biological sample are described herein. In one embodiment, the biological sample is taken from an animal, such as a human. Suitable classes of drugs include drugs prone to abuse and prescription medications. In one embodiment, the biological sample is enzymatically hydrolyzed to liberate free drug in the sample. Once the biological sample has been prepared, the sample is extracted using solid-phase extraction (SPE). Following solid phase extraction (SPE), the resulting eluate containing the compounds to be detected is diluted and injected into a liquid chromatograph coupled to a triple quadrupole mass spectrometer. Multiple classes of drugs can be analyzed simultaneously in less than about 13 minutes, preferably less than about 11 minutes, more preferably less than about 10 minutes, more preferably less than about 9 minutes, most preferably less than about 8 minutes. | 06-21-2012 |
20120153139 | GENERATION OF MODEL-OF-COMPOSITION OF PETROLEUM BY HIGH RESOLUTION MASS SPECTROMETRY AND ASSOCIATED ANALYTICS - A method to determine the model-of-composition of a vacuum resid wherein the resid is separated into eight fractions, saturates, aromatics, sulfides and polars by a combination of soft ionization methods. | 06-21-2012 |
20120153140 | Apparatus and Methods for Ion Mobility Spectrometry - There is provided of an on mobility spectrometer for separating ions according to their on mobility comprising, in various aspects: a drift tube having therein a drift space and in the drift space at least two on separation paths of different lengths: a straight drift tube having therein a helical ion separation path; a helical on separation path surrounding an axially extending inner electrode assembly; and a drift tube for separating ions according to their ion mobility wherein a rotating arcuate electric field is applied in operation to separate ions having an ion mobility such that their rotational velocity in the drift tube is matched to the rotational velocity of the rotating arcuate electric field. Various methods for separating ions according to their on mobility are also provided. | 06-21-2012 |
20120153141 | Ion Transfer Tube for a Mass Spectrometer System - An ion transfer tube for a mass spectrometer comprises a core member and a first jacket tube member at least partially enclosing the core member and providing one or more channels therethrough. A method of forming an ion transfer tube, comprises: providing a first jacket tube member having a length and an internal bore, the internal bore passing along the length and defining an interior surface of circular cross section; removing at least one portion of the first jacket tube member adjacent to the interior surface so as to form at least one groove, channel, slot, recess or embayment of or in the interior surface; and providing a core member within the bore of the jacket tube member such that remnant portions of the interior surface of circular cross section mate against portions of an exterior surface of the core member. | 06-21-2012 |
20120153142 | NANOPHOTONIC PRODUCTION, MODULATION AND SWITCHING OF IONS BY SILICON MICROCOLUMN ARRAYS - The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of laser light polarization and the angle of incidence. By providing photonic ion sources, this enables enhanced control of ion production on a micro/nano scale and direct integration with miniaturized analytical devices. | 06-21-2012 |
20120153143 | ELECTROSPRAY AND NANOSPRAY IONIZATION OF DISCRETE SAMPLES IN DROPLET FORMAT - Droplets or plugs within multiphase microfluidic systems have rapidly gained interest as a way to manipulate samples and chemical reactions on the femtoliter to microliter scale. Chemical analysis of the plugs remains a challenge. It has been discovered that nanoliter plugs of sample separated by air or oil can be analyzed by electrospray ionization mass spectrometry when pumped directly into a fused silica nanospray emitter nozzle. Using leu-enkephalin in methanol and 1% acetic acid in water (50:50 v:v) as a model sample, we found carry-over between plugs was <0.1% and relative standard deviation of signal for a series of plugs was 3%. Detection limits were 1 nM. Sample analysis rates of 0.8 Hz were achieved by pumping 13 nL samples separated by 3 mm long air gaps in a 75 μm inner diameter tube. Analysis rates were limited by the scan time of the ion trap mass spectrometer. The system provides a robust, rapid, and information-rich method for chemical analysis of sample in segmented flow systems. | 06-21-2012 |
20120160997 | Non-radioactive ion sources with ion flow control - An ion-based analyzer including a non-radioactive ion source, an ion generation chamber for generating ions, a sample ionization chamber and a controller for employing ion flow control, an ion-based filter, and a detector for analyzing a sample. | 06-28-2012 |
20120168616 | SAMPLE FEEDING DEVICE FOR ION MOBILITY SPECTROMETER, METHOD OF USING THE SAME AND ION MOBILITY SPECTROMETER - The present invention discloses a sample feeding device for an ion mobility spectrometer, which is adapted to guide a sample to be detected into an inlet of a drift tube of the ion mobility spectrometer. The sample feeding device comprises a solid sample feeding component; a sample inlet component; a attachment component, wherein the solid sample feeding component has an internal cavity defined therein, one end of the solid sample feeding component is communicated with the sample inlet component through the internal cavity, while the other end is communicated with the inlet of the ion drift tube through the attachment component; and a gaseous sample feeding component, comprising a body and an external attachment component, the body has a gas channel therein, and the external attachment component includes an inlet hole which is communicated with the gas channel, wherein when the external attachment component is fitted with the sample inlet component, the body is inserted into the internal cavity, so that a channel of the solid sample feeding component is closed, and only the gas channel of the gaseous sample feeding component is communicated with the inlet of the drift tube of the ion mobility spectrometer. | 07-05-2012 |
20120168617 | SAMPLING DEVICE FOR ION MIGRATION SPECTROMETER AND METHOD FOR USING THE SAME, AND ION MIGRATION SPECTROMETER - The present invention discloses a sampling device for an ion migration spectrometer (IMS), comprising: an inner sleeve part, inside of which an inner cavity is defined, one end of the inner sleeve part is connected with an inlet of an migration pipe via an inner-layer channel, and the other end of the inner sleeve part is configured with an inner end cap having an inner opening; and an outer sleeve part, which is configured as an eccentric sleeve that is coaxial with the inner sleeve part and able to rotate with respect to the inner sleeve part, so as to form a sleeve cavity between the inner sleeve part and the outer sleeve part, wherein one end of the outer sleeve part is configured with at least one connecting opening that is selectively connected with the inner-layer channel, and the other end of the outer sleeve part is configured with an outer end cap, on which a first outer opening selectively connected with the inner opening and a second outer opening selectively connected with the sleeve cavity are configured, wherein the outer end cap is configured to be able to rotate between a first location and a second location with respect to the inner end cap, so as to selectively introduce a sample to be detected into the inner-layer channel via one of the inner cavity and the sleeve cavity. Moreover, the present invention further relates to a method for solid and gas sampling by using the above sampling device. | 07-05-2012 |
20120168618 | Tandem Time-Of-Flight Mass Spectrometry With Simultaneous Space And Velocity Focusing - A tandem TOF mass spectrometer includes a first TOF mass analyzer that generates an ion beam comprising a plurality of ions and that selects a group of precursor ions from the plurality of ions. A pulsed ion accelerator accelerates and refocuses the selected group of precursor ions. An ion fragmentation chamber is positioned to receive the selected group of precursor ions that is refocused by the pulsed ion accelerator. At least some of the selected group of precursor ions is fragmented in the ion fragmentation chamber. A second TOF mass analyzer receives the selected group of precursor ions and ion fragments thereof from the ion fragmentation chamber and separates the ion fragments and then detects a fragment ion mass spectrum. | 07-05-2012 |
20120168619 | METHODS AND SYSTEMS FOR PROVIDING A SUBSTANTIALLY QUADRUPOLE FIELD WITH A HIGHER ORDER COMPONENT - A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A | 07-05-2012 |
20120175515 | SAMPLE SUBSTRATE FOR LASER DESORPTION IONIZATION-MASS SPECTROMETRY, AND METHOD AND DEVICE BOTH USING THE SAME FOR LASER DESORPTION IONIZATION-MASS SPECTROMETRY - An object of the present invention is to provide a sample substrate for laser desorption ionization mass spectrometry for LDI-MS which substrate enables mass spectrometric analysis of a sample correctly at high sensitivity without generating interference peaks upon irradiation of the sample to laser light and uniform application of the sample onto a base. Another object of the invention is to provide a mass spectrometer (device) employing the sample substrate. | 07-12-2012 |
20120175516 | VAPOUR GENERATORS - A vapour generator system ( | 07-12-2012 |
20120175517 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 07-12-2012 |
20120181421 | INFORMATION ACQUISITION METHOD - Provided is a method that achieves both of soft ionization and high ionization efficiency of a substance to be analyzed at each measurement site without impairing a two-dimensional distribution state of the substance to be analyzed in desorption ionization mass spectrometry of a substance to be measured. By applying, to a substance to be analyzed, an ionization assisting reagent including an organic acid including a functional group represented by —(CF | 07-19-2012 |
20120187287 | Substrate compositions and methods of use thereof - The subject matter provided herein relates to substrates for desorbing and ionizing analytes, and kits and methods of use thereof. The substrate provided herein comprises a porous semiconductor, a fluorous initiator, and a photoactive compound containing a fluorous group. | 07-26-2012 |
20120187288 | SAMPLE HOLDER FOR MALDI MASS SPECTROMETRIC ANALYSIS, AND MASS SPECTROMETRIC ANALYSIS METHOD - Used is a sample holder for MALDI mass spectrometry, which has a CuO secondary particle as a laser-beam-absorbing matrix and in which the secondary particle comprises an aggregate of CuO primary particles having an average particle diameter of 100 nm or smaller and has an uneven surface arising from the shape formed by the primary particles constituting the outermost surface of the secondary particle. As the CuO secondary particle, usable is one derived from a CuO powder produced by baking basic copper carbonate in air at 200 to 300° C., and the basic copper carbonate is produced in a process of mixing an aqueous ammonium hydrogencarbonate solution and an aqueous copper nitrate solution. The CuO secondary particle has an average particle diameter of, for example, from 0.3 to 10 μm. | 07-26-2012 |
20120187289 | METHOD FOR THE DIAGNOSIS OF NON-ALCOHOLIC STEATOHEPATITIS BASED ON A METABOLOMIC PROFILE - The invention relates to methods for the diagnosis of non-alcoholic steatosis (NASH). The method relies on the determination of certain metabolic markers in a biological sample of the patient which are up- or down-regulated in the NASH patients vs. patients with a simple fatty liver (steatosis). | 07-26-2012 |
20120193524 | MASS SPECTROMETER AND MASS ANALYZER COMPRISING PULSER - A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite one another, parallel to one another, and axially offset from one another. One of the pair of planar electrodes comprises an opening. The mass analyzer comprises an ion mirror disposed between the pair of planar electrodes. A mass spectrometer and a mass spectrometry method are also described. | 08-02-2012 |
20120193525 | Predictive test for selection of metastatic breast cancer patients for hormonal and combination therapy - A mass-spectral method is disclosed for determining whether a breast cancer patient is likely to benefit from administration of a combination treatment in the form of a targeted anti-cancer drug in addition to an endocrine therapy drug. The method obtains a mass spectrum from a blood-based sample from the patient. The spectrum is subject to one or more predefined pre-processing steps. Values of selected features in the spectrum at one or more predefined m/z ranges are obtained. The values are used in a classification algorithm using a training set comprising class-labeled spectra a class label for the sample is obtained. If the class label is “Poor”, the patient is identified as being likely to benefit from the combination treatment. In a variation, the “Poor” class label predicts whether the patient is unlikely to benefit from endocrine therapy drugs alone, regardless of the patient's HER2 status. | 08-02-2012 |
20120193526 | Ion Interface Device Having Multiple Confinement Cells and Methods of Use Thereof - A device and associated methods of operations are disclosed for interfacing on ion trap to a mass analyzer, such as a TOF mass analyzer. The device includes a plurality of sequentially arranged confinement cells having fixed locations. A group of ions, e.g., ions within a relatively narrow window of mass-to-charge ratio, is received by the device from the ion trap, undergoes fragmentation, and is transported through the device from a first to final confinement cell by a series of transfers between adjacent cells. The ion group is confined in each cell for a prescribed cooling period. By providing a suitable aggregate ion confinement time and by enabling concurrent transport and cooling of successively ejected ion groups, the ions are cooled sufficiently to enable the acquisition of mass spectra at high resolution, without having to substantially delay the ejection of a subsequent group of ions from the ion trap until cooling of the previous group is completed. | 08-02-2012 |
20120193527 | Novel Renal Disease Marker Substance in Human - An object of the present invention is to provide a method for accurately determining even a renal disease that could not have been detected by various conventional renal disease test methods with a reduced burden on a subject (a donor of a test sample). Another object of the present invention is to provide a method capable of determining an early stage renal disease, focusing on a renal disease marker substance with a small blind GFR area. Further, another object of the present invention is to provide a novel method for screening for a prophylactic/therapeutic agent for a renal disease capable of efficiently screening for a novel prophylactic/therapeutic agent for a renal disease that focused on a new, previously unnoticed renal disease marker substance. In order to achieve these objects, the present invention employs the step of detecting or quantifying one or two or more renal disease marker substances present in a test blood sample. | 08-02-2012 |
20120193528 | QUANTITATIVE DETERMINATION OF RISEDRONATE IN URINE BY SPE-LC-MS-MS - The present invention is directed to a SPE-LC-MS-MS method for quantitatively determining risedronate in a urine sample. | 08-02-2012 |
20120193529 | ION CYCLOTRON RESONANCE MEASURING CELLS WITH HARMONIC TRAPPING POTENTIAL - The invention relates to devices and methods for the acquisition of mass spectra with very high mass resolution in ion cyclotron resonance mass spectrometers and methods to produce the devices. The invention presents cylindrical ICR measuring cells with special electrode geometries to generate harmonic trapping potentials for orbiting ions up to the walls of the cell. Only a single DC trapping voltage has to be applied to create the harmonic trapping potential distribution. The sheath of the cylindrical cell is divided by longitudinal gaps into a multitude of sheath electrodes, which either have to carry layers with resistance profiles able to generate parabolic voltage profiles along the sheath electrodes, or which form sheath electrodes of varying width by parabolic gaps, able to create complicated potential distributions which are harmonic on average for orbiting ions. Orbiting ions of a given mass m/z can oscillate harmonically in axial direction with exactly the same oscillation frequency, independent of the radius of their orbit and of their axial oscillation amplitude. Ideally, the cylinders are closed by endcaps with rotationally hyperbolic form, divided into partial electrodes like in infinity cells. The ions can then be excited to their cyclotron motions by dipolar excitation fields also uniformly filling the ICR cell up to the endcaps. The ion clouds orbiting on their cyclotron trajectory are kept together for much longer periods than was possible hitherto, even if they orbit near the sheath electrodes. The image currents thus give rise to minute-long transients, from which mass spectra with ultrahigh mass resolution can be obtained. | 08-02-2012 |
20120199732 | METHODS AND APPARATUS FOR MASS SPECTROMETRY UTILIZING AN AC ELECTROSPRAY DEVICE - An alternating current electrospray mass spectrometry device includes an electrospray device having at least one emitter providing a passageway for transmission of an analyte sample. At least one conductive element is in electrical communication with the at least one emitter. A power source generates an alternating current electric field to form a liquid cone at a tip of the emitter and ionizes the analyte sample present in the liquid cone. The frequency of the electric field entrains low mobility ions in the liquid cone. The AC electric field causes the emitter to discharge the liquid cone as a liquid aerosol drop, and a mass spectrometry device analyzes the ionized analyte sample to determine the composition of the contained analyte sample. | 08-09-2012 |
20120199733 | METHOD FOR THE DIAGNOSIS OF PATHOLOGICAL CONDITIONS IN ANIMALS - Provided is a method for diagnosing a disease or pathological condition in an animal. An ion mobility spectrometry measurement (IMS) or a differential mobility spectrometry (DMS) is carried out on a body sample from the animal to determine an amount of ions formed by at least two biogenic amines contained in the sample. A ratio is calculated of the amounts of ions formed by the different biogenic amines in the sample, wherein the ratio is indicative of the presence or absence of the disease or pathological condition. Also provided is a device for collecting a body sample from an animal and a method for obtaining a body sample from an animal. | 08-09-2012 |
20120199734 | Mass Spectrometer - An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyser. | 08-09-2012 |
20120205531 | Quantitation Precision for Isobarically Labeled Peptides Using Charge State Targeted Dissociation - The instrument initially assesses the purity of a given candidate parent. If the candidate parent is contaminated with an isobaric signal(s), it promptly focuses on the alternative charge state(s) for the same neutral mass. Specifically for every peptide mass there are almost universally several charge states (usually 1-4 for tryptic peptides) present in the ESI spectrum. An optional step may be used for more complex situations where alternative (lower) charge states are not evident in the spectrum. In this case, proton transfer is performed on a higher charge state. Next, if the reduced ion parent is isobarically pure, a higher energy collisionally activated dissociation is performed on the reduced ion parent. Alternatively, a dedicated targeted isolation can be performed for low abundant precursors at calculated m/z if they fall below LOD of the analyzer full scan. | 08-16-2012 |
20120205532 | Techniques For Sample Analysis - Techniques are described for performing sample analysis. Liquid chromatographic separation of a sample is performed and an eluent is generated. Mass spectrometry on said eluent is performed to detect a compound where the compound may occur in trace amounts. The compound may have a concentration, for example, of approximately less than one part per trillion. | 08-16-2012 |
20120205533 | METHODS AND SYSTEMS FOR THE QUANTITATIVE CHEMICAL SPECIATION OF HEAVY METALS AND OTHER TOXIC POLLUTANTS - This invention relates to systems and methods for measuring quantitatively multiple species or heavy metals, including mercury, and other toxic pollutants. More specifically, the systems and methods of the invention allows for determination of the analytes even at very low concentration, through concentration on a collection interface, desorption and analysis by mass spectrometry. The invention also provides for a portable device or kit for modifying an existing mass spectrometer. | 08-16-2012 |
20120205534 | METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY - A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer. | 08-16-2012 |
20120205535 | METHOD FOR DETECTING MOLECULES THROUGH MASS SPECTROMETRY - A method for detecting at least one target molecule in a sample by mass spectrometry, comprising ionizing the molecules of the sample and then conducting the following steps (i) and (ii) n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyser, and (ii) the ion thus selected is fragmented in a fragmentation cell; trapping at least two different sampled ions, when n is zero, or when n is other than zero, in a mass analyser, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule; ejecting the trapped ions from the mass analyser; and detecting the ejected ions ejected by means of a detection device. The method is characterized in that the characteristic ions are ejected simultaneously and detected simultaneously. | 08-16-2012 |
20120217387 | ION SLICER WITH ACCELLERATION AND DECELLERATION OPTICS - Described herein is an ion slicer that: a) accelerates an ion beam towards a first electrode comprising an ion entrance slit, where the first electrode blocks a portion of ions with high displacement from the axis of the ion beam, thereby slicing the ion beam; and then b) decelerates the ion beam after it is sliced. | 08-30-2012 |
20120223222 | ISOLATION OF IONS IN OVERLOADED RF ION TRAPS - In an RF quadrupole ion trap having electrodes to which RF voltages are applied, ions having m/z ratios outside of a predefined narrow range of charge-related masses m/z are removed from the trap by applying a DC voltage pulse to at least one of the trap electrodes to remove from the trap the ions with high values of charge-related masses. The DC voltage pulse is preferably applied in combination with a variation of the RF voltage amplitudes to simultaneously remove from the trap ions of low charge-related masses. The DC and RF voltage amplitudes are changed in such a manner that any excitation of ions having charge-related masses within the predefined range by frequency mixtures is avoided. | 09-06-2012 |
20120223223 | MASS SPECTROMETER METHOD AND MASS SPECTROMETER - A variation in an ionization efficiency and the amount of sample which is introduced into an ion trap is corrected and quantified. Ions of an internal standard and ions of a sample are trapped in the ion trap at the same time, and a concentration of the sample is quantified according to an intensity of the ions of the internal standard which are mass-selectively ejected, and an intensity of fragment ions of the sample. | 09-06-2012 |
20120223224 | METHOD FOR SIMULTANEOUS CALIBRATION OF MASS SPECTRA AND IDENTIFICATION OF PEPTIDES IN PROTEOMIC ANALYSIS - The invention relates to a mass spectrometry calibration system that may be performed in real-time using the information contained within a sample without the addition of specific calibrants. When applied to a sample, such as a proteomic sample, the calibration system may identify the exact masses of peptides in the sample. The system involves the use of mathematical algorithms that iteratively estimate the error in the measurement and update the calibration parameters accordingly; thereby resulting in peptide mass identification. | 09-06-2012 |
20120228487 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 09-13-2012 |
20120228488 | PROCESSING OF ION CURRENT MEASUREMENTS IN TIME-OF-FLIGHT MASS SPECTROMETERS - Methods and instruments are provided for processing individual spectra of a time-of-flight mass spectrometer to form a sum spectrum. According to an aspect of the invention, a peak position on a flight time scale and a total intensity are determined for each peak in the individual spectrum. Intensity entries of the sum spectrum are selected, the flight times of which are positioned on both sides of the peak position. The total intensity is added to the selected intensity entries, where more of the total intensity is added to the intensity entries that are closer to the peak position than is added to the intensity entries that are further away from the peak position. | 09-13-2012 |
20120228489 | ASSESSING THE CONTAMINATION IN A MASS-SPECTROMETRIC MALDI ION SOURCE - The invention relates to a method by which the operator of a mass spectrometer with a MALDI ion source, particularly one which operates with delayed extraction of the ions, is provided with a technique for determining the degree of contamination, in particular to determine when the ion source must be cleaned. The method comprises the acquisition of at least one mass spectrum of ions which are generated in the ion source, the recording of at least one characteristic value for each of at least two mass signals in the mass spectrum, and the determination of an indicator number, derived from the characteristic values of at least two mass signals, which shows how urgently the ion source must be cleaned. The invention also relates to a mass spectrometer with a MALDI ion source which can be characterized accordingly. | 09-13-2012 |
20120228490 | APPARATUS AND METHOD FOR ION MOBILITY SPECTROMETRY AND SAMPLE INTRODUCTION - The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. | 09-13-2012 |
20120228491 | HIGH PERFORMANCE ION MOBILITY SPECTROMETER APPARATUS AND METHODS - An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation. | 09-13-2012 |
20120235031 | INTERFACE FOR THE RAPID ANALYSIS OF LIQUID SAMPLES BY ACCELERATOR MASS SPECTROMETRY - An interface for the analysis of liquid sample having carbon content by an accelerator mass spectrometer including a wire, defects on the wire, a system for moving the wire, a droplet maker for producing droplets of the liquid sample and placing the droplets of the liquid sample on the wire in the defects, a system that converts the carbon content of the droplets of the liquid sample to carbon dioxide gas in a helium stream, and a gas-accepting ion source connected to the accelerator mass spectrometer that receives the carbon dioxide gas of the sample in a helium stream and introduces the carbon dioxide gas of the sample into the accelerator mass spectrometer. | 09-20-2012 |
20120235032 | Ionization Method, Ion Producing Device and Uses of the Same in Ion Mobility Spectrometry - A method for ionizing, using pulses of ionization radiation, an analyte to be examined by way of ion mobility spectrometry using a pulse sequence is modulated with a known time-variable impression pattern is provided. An ionization device for carrying out the method and an ion mobility spectrometry method and an ion mobility spectrometry device that use the ionization method and/or the ionization device are also provided. | 09-20-2012 |
20120235033 | DIFFERENTIAL MOBILITY ANALYZER - The object of this invention is a differential mobility analyzer (DMA). Differential mobility analyzers allow classifying charged particles by their electrical mobility. The sample to analyze requires the use of a charging stage, which, in the state of the art, takes place outside of a classification region, so that the sample, once charged, is injected into the classification region of the differential mobility analyzer. Instead, the present invention charges the sample to analyze inside the classification region, to eliminate the time elapsing between the generation of the charged particles and their arrival to the classification region, resulting in a reduction in the time available for the ions to recombine. The invention improves the results obtained as recombination of the charged particles makes the results unreliable. | 09-20-2012 |
20120241601 | METHODS AND APPARATUS FOR DETECTING AIRBORNE MOLECULAR CONTAMINANTS - Methods and apparatuses for the removal, analysis and/or detection of harmful airborne molecular contaminants (AMCs). In one embodiment, an ionizing radiation source is utilized to remove the harmful AMCs from a flow stream via radiolytic particle generation and subsequent capture by filtration. The captured particles may be released, for example, by re-gasification for analysis at much higher concentrations. In another embodiment, the ionizing radiation source is utilized with a particle detector to sense when harmful AMCs are present. In one embodiment, a solid optical medium is exposed to a monitored environment so that the AMCs are in contact with a surface of the solid optical medium. A focused light beam is arranged to emerge from a solid optical medium at an energy density sufficient to cause the AMCs to form deposits on the exposed surface of the solid optical medium, which can be detected using an interferometric technique. | 09-27-2012 |
20120241602 | Method of Screening a Sample for the Presence of One or More Known Compounds of Interest and a Mass Spectrometer Performing this Method - A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation. A determination is made whether a candidate parent ion of interest is present in a non-fragmentation data set and whether one or more corresponding fragment ions of interest are present in a fragmentation data set. A further determination is made to check if the candidate parent ion of interest and the one or more corresponding fragment ions of interest have substantially similar elution or retention times and/or ion mobility drift times. | 09-27-2012 |
20120241603 | MULTIPLEXED TANDEM MASS SPECTROMETRY METHOD - The invention concerns a method for multiplexed tandem mass spectrometry of a sample to be analysed containing at least two precursors, wherein at least two simplified multiplexed MS-MS spectra are obtained each from at least two selected precursors of the sample, the method comprising: (d) for each selected precursor generating an individual MS-MS spectrum from the simplified multiplexed MS-MS spectrum by selecting fragment ions of the simplified multiplexed MS-MS spectrum, the fragment ions are potential fragment ions obtained from the precursor; (e) submitting each individual MS-MS spectrum of step (d) to a real and a decoy database searches using a scoring process without score threshold condition or low score threshold condition for identifying candidate precursors and their fragment ions; (f) producing real individual MS-MS spectra from identified candidate precursors resulting from the real database search of step (e); and producing decoy individual MS-MS spectra from identified candidate precursors resulting from the decoy database search of step (e); (g) submitting the real and decoy individual MS-MS spectra to a further scoring process with a score threshold condition for determining a score for each real and decoy individual MS-MS spectra. | 09-27-2012 |
20120248301 | UV-LED IONIZATION SOURCE AND PROCESS FOR LOW ENERGY PHOTOEMISSION IONIZATION - A UV-LED photoemission ionization source and process are disclosed that provide ionization of analytes including volatile molecular species and organic residues for detection with various ion analyzers. The UV-LED source produces low-energy UV light (200 nm to 400 nm) that yields photoemission electrons from various conducting surfaces. These photoemission electrons provide direct and indirect ionization of analytes including trace organic residues without need of high electric fields. | 10-04-2012 |
20120248302 | DRIVE UNIT FOR A SYNCHRONOUS ION SHIELD MASS SEPARATOR - A drive unit for a synchronous ion shield mass separator having a reference oscillator ( | 10-04-2012 |
20120248303 | IONIZATION METHOD AND APPARATUS USING ELECTROSPRAY, AND ANALYZING METHOD AND APPARATUS - It is arranged so that living tissue that has not been pretreated can be adopted as a sample of interest. A sample is introduced into at least a tip portion of a hollow insulated sample holder | 10-04-2012 |
20120256082 | PHASE SHIFT RF ION TRAP DEVICE - A novel ion trap made of at least two ion guides sets separated by a gap and each guide consists of three or more rods-like multipole carrying radio frequency (RF) voltages with delayed phases. The injected ions are axially or orthogonally, contained by pulsed DC and/or RF voltages. When the ions translational energy is damped due to collisions with a low-pressurized inert gas, the 3-D RF field in the gap, which is created by the special rod and electricity arrangement, can trap the ions and compact them in a dense ion cloud. Because the ions are trapped in the small gap, new ions can be injected and the trapping cycle can be repeated many times before the ion ejection. The ions are ejected from the gap orthogonally or axially. This ion trap is useful for mass spectrometry and beam physics, specifically for high efficient ion accumulation and focusing the ions in a small space. | 10-11-2012 |
20120256083 | High Duty Cycle Ion Storage/Ion Mobility Separation Mass Spectrometer - A novel high ion storage/ ion mobility separation mass spectrometer that provides for a high duty cycle of operation is presented herein. In particular, the example embodiments, as disclosed herein, provides for a high ion storage/ion mobility instrument that beneficially includes a two-dimensional (2D) plurality of adjacently arranged ion confinement channels to provide a high storage bank of a desired mass range of ions. Such ions, via ion mobility transport, are separated into smaller fractions of an overall mass window into desired confinement regions of the disclosed 2D confinement channels and thereafter transferred out in a manner so as to enable the aforementioned novel high-duty cycle of sequential operation. | 10-11-2012 |
20120261564 | METHOD AND APPARATUS FOR COUPLING FAST SEPARATIONS AND SLOW DETECTION SYSTEMS - An apparatus and method for analyzing a sample containing multiple analytes that combines a separation device that separates the individual analytes by virtue of some physical and/or chemical characteristic other than the mass to charge ratio (m/z) interfaced with a mass spectrometer that detects the m/z of individual analytes. Separation is performed on the shorter timescale than signal detection with the mass spectrometer. A preferred embodiment utilizes an ion mobility spectrometer interfaced with an Orbitrap mass spectrometer. | 10-18-2012 |
20120261565 | WIDE APERATURE WIEN EXB MASS FILTER - An ExB Wien mass filter provides an independently-adjustable electric field combined with the dipole electric field required for mass separation. The independently adjustable electric field can be used provide a larger optical aperture, to correct astigmatism and to deflect the beam in direction parallel and/or perpendicular to the magnetic field. | 10-18-2012 |
20120261566 | ABERRATION-CORRECTED WIEN EXB MASS FILTER WITH REMOVAL OF NEUTRALS FROM THE BEAM - A mass filter for an ion beam system includes at least two stages and reduces chromatic aberration. One embodiment includes two symmetrical mass filter stages, the combination of which reduces or eliminates chromatic aberration, and entrance and exit fringing field errors. Embodiments can also prevent neutral particles from reaching the sample surface and avoid crossovers in the beam path. In one embodiment, the filter can pass a single species of ion from a source that produces multiple species. In other embodiments, the filter can pass a single ion species with a range of energies and focus the multi-energetic ions at the same point on the substrate surface. | 10-18-2012 |
20120261567 | METAL OXIDE LASER IONIZATION-MASS SPECTROMETRY - Disclosed herein are metal oxides, metal oxide surfaces, and methods of using metal oxides and metal oxide surfaces for matrix-free analysis, identification, and characterization of small molecular mass compounds. The disclosed compounds and methods may be used with laser desorption/ionization-mass spectrometry. The disclosed surfaces may aid in producing mass/charge spectra having low or no interference found with traditional matrices. In some aspects, the method may be used to produce molecular ions. The disclosed compounds, surfaces, and methods may be used to analyze complex mixtures including fuels, vegetable shortening, lipid extracts from a variety of organic sources such as animals, plants, bacteria, algae, viruses, etc | 10-18-2012 |
20120261568 | PRECURSOR SELECTION USING AN ARTIFICIAL INTELLIGENCE ALGORITHM INCREASES PROTEOMIC SAMPLE COVERAGE AND REPRODUCIBILITY - Described herein are mass spectrometry systems and methods which utilize a dynamic a new data acquisition/instrument control methodology. These systems and methods employ novel artificial intelligence algorithms to greatly increase quantitative and/or identification accuracy during data acquisition. In an embodiment, the algorithms can adapt the instrument methods and systems during data acquisition to direct data acquisition resources to increase quantitative or identification accuracy of target analytes, such as proteins, peptides, and peptide fragments. | 10-18-2012 |
20120261569 | METHOD AND DEVICE FOR DETERMINING LEAKAGE - In order to determine leakage on a device, which contains gas that can be condensed, an adsorbent is used through which ambient gas of the object is conducted. The adsorbed gas is desorbed by means of actuating an excitation device and fed to a gas sensor containing a mass spectrometer. In this way, minute amounts of leaking gas can be determined by means of accumulation. The method is in particular suited for use in the serial production of refrigeration machines. | 10-18-2012 |
20120267521 | SYSTEM AND METHOD TO ELIMINATE RADIO FREQUENCY COUPLING BETWEEN COMPONENTS IN MASS SPECTROMETERS - A radio frequency component for use in a mass spectrometer is described. The radio frequency component includes a plurality of electrodes. The plurality of electrodes is configured around a central axis to create an ion channel within the plurality of electrodes. In addition, each of the plurality of electrodes is paired with an opposing electrode across the central axis. And, at least one electrode pair has an electrode extension on each electrode. The electrode extension is configured to overlap at least a portion of a proximate electrode of a second radio frequency component. | 10-25-2012 |
20120267522 | METHOD AND APPARATUS FOR IDENTIFYING PROTEINS IN MIXTURES - Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed and a target peptide is selected from produced peptides. The masses of the Y- and B-ion fragments of the target peptide are determined. These masses are used to search previously obtained low- and high-energy AMRTs obtained from LC/MS analysis of the complex sample for masses on the list. Any mass observed in the data within a detection threshold are considered a hit. If enough hits accumulate in a given retention time, the target peptide is identified as being in the sample. The list of peptides identified in the complex sample can be used to identify the proteins present in the sample, track the chromatographic retention times of peptides between samples, and quantitate the peptides and proteins present in complex samples. | 10-25-2012 |
20120273669 | Chemical analysis using hyphenated low and high field ion mobility - Using combined orthogonal techniques, such as low (IMS) and high (FAIMS) field mobility techniques, offers several advantages to ion detection and analysis techniques including low cost, no vacuum required, and the generation of 2-D spectra for enhanced detection and identification. Two analytical devices may be operated in different modes, which results in overall flexibility by adapting the hyphenated instrument to the application's requirements. With the IMS-FAIMS hardware level flexibility, the instruments may be configured and optimized to exploit different trade-offs suitable for a variety of detection scenarios of for different lists of target compounds. | 11-01-2012 |
20120273670 | Spectrum Acquisition Modes For Ion Mobility Spectrometers Using Trapped Ions - In an ion mobility spectrometer in which a gas flows through a gas-tight tube with a radially quadrupolar RF field therein and blows ions against a DC electric field barrier, a mobility scan with a mobility scale that is linear in time is obtained by holding the height of the DC electric field barrier constant while changing the pressure and temperature conditions of the flowing gas. Alternatively, the mobility scan is performed by holding the pressure and temperature conditions of the flowing gas constant and reducing the height of the DC electric field barrier non-linearly with respect to time. | 11-01-2012 |
20120273671 | METHOD AND KIT FOR DETERMINING METABOLITES ON DRIED BLOOD SPOT SAMPLES - A method for individuating with high sensitivity and specificity ADA metabolites from dried blood spot. The method described herein can be used to extract Adenosine and Deoxyadenosine from a sample under conditions that permit concurrently extracting other metabolites, such as amino acids, free carnitine, or acylcarnitines. For example, harsh extraction conditions (such as extreme acidity and high temperature) can be avoided. The method can be used, along with other neonatal screenings, on blood samples and preferably on dried blood spots (Guthrie cards) and more preferably on Guthrie cards obtained in the II-IV day of life. The method is reliable and reproducible, easy to perform and gives a definitive response within a short time (1-2 days). One or more kit for use in the method. | 11-01-2012 |
20120273672 | Spectrometer Apparatus - An ion mobility spectrometer has several electrodes spaced along its ion source region. Voltages are applied to the electrodes to produce a voltage gradient along the length of the ion source region. By varying the voltage gradient, the residence time of ions in the ion source region can be selectively varied. Typically, the spectrometer is arranged to reduce the residence time in response to a decrease in the amplitude, of an ion peak detected at the far end of the drift region. | 11-01-2012 |
20120280118 | METHOD FOR OPERATING A TIME-OF-FLIGHT MASS SPECTROMETER WITH ORTHOGONAL ION PULSING - Methods are provided for acquiring sum spectra in a time-of-flight mass spectrometer with orthogonal pulsed acceleration, where each of the sum spectra is obtained from a plurality of summed individual spectra. The mass spectrometer has an ion storage device that collects the ions temporarily before they are transferred to an ion pulser, which pulses out the ions orthogonally. Acquisition conditions such as, for example, delay times between opening the ion storage device and the pulsed ejection in the ion pulser are varied for the individual spectra, which are added together to form the sum spectrum of ions with light masses and high masses. | 11-08-2012 |
20120280119 | SAMPLING OF CONFINED SPACES - In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container. | 11-08-2012 |
20120280120 | METHOD AND SYSTEM FOR VACUUM DRIVEN MASS SPECTROMETER INTERFACE WITH ADJUSTABLE RESOLUTION AND SELECTIVITY - A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit. | 11-08-2012 |
20120286150 | METHOD AND APPARATUS FOR TRANSMITTING IONS IN A MASS SPECTROMETER MAINTAINED IN A SUB-ATMOSPHERIC PRESSURE REGIME - A method and apparatus for transmitting ions in a mass spectrometer from an ion source to a mass analyzer extracts analyte ions from the ion source in such a manner that the number of extracted analyte ions is maximized. The ions are then transmitted through an ion guide to the mass analyzer. The ion guide is filled with an interaction gas and its operating parameters are adjusted so that, as the ions pass through the ion guide, the analyte ion energy distribution width is narrowed and the analyte ions are collimated within the ion guide to improve the resolution and sensitivity of the mass analyzer. | 11-15-2012 |
20120286151 | Devices and Methods for Analyzing Surfaces - Embodiments of the present invention are directed to devices and methods for performing an analysis of a sample having a sample surface. The device and method feature a frame element affixed to a sample holder, jet element and a charged particle analyzer having an ion receiving orifice. The jet element directs a jet of gas towards the sample surface held by said sample holder focused on less than 2.0 mm | 11-15-2012 |
20120286152 | ION SOURCE WITH SURFACE COATING - A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal. | 11-15-2012 |
20120286153 | METHOD OF CONTROLLING ION IMPLANTATION APPARATUS - Provided is a method of controlling an ion implantation apparatus | 11-15-2012 |
20120286154 | METHOD AND DEVICE FOR REPETITIVE CHEMICAL ANALYSIS OF A GAS FLOW - The present invention relates to a method for repetitive chemical analysis of a gas flow, wherein said gas flow consists of a carrier gas and gaseous chemical compounds, comprising the following method steps: feeding said gas flow to a gas chromatographic separation column by means of a feeding device; collecting at least a part of said gaseous chemical compounds for a defined time period by means of a thermally based collecting device which is coupled to said gas chromatographic separation column and/or said feeding device; releasing said collected gaseous chemical compounds in a temporally focused manner by means of said thermally based collecting device; separating said released gaseous chemical compounds by means of said gas chromatographic separation column; and analyzing said separated gaseous chemical compounds by means of an analyzer. The present invention further relates to a device for performing such a method. | 11-15-2012 |
20120286155 | High Sensitivity Mass Spectrometry Systems - A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte. | 11-15-2012 |
20120286156 | SELECTIVE ION MOBILITY SPECTROMETER - Ions with a predetermined ion mobility range are produced by filtering ions entrained in a stream of moving gas with two ion mobility low pass filters located consecutively in the gas stream. Each filter is formed by applying a DC electric field to the gas stream which causes the ions to move in a direction opposite to the gas flow. Ions are collected between the two filters and transferred to a detector or analyzing device. In one embodiment, the maximum field strength of the electric field barrier in the first ion mobility low pass filter is continued as a plateau of essentially constant field strength up to the electric field barrier in the second ion mobility low pass filter, which has a maximum field strength higher that the maximum field strength of the electric field barrier in the first ion mobility low pass filter. | 11-15-2012 |
20120286157 | Means and Methods for Diagnosing Heart Failure in a Subject - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 11-15-2012 |
20120292496 | FLOW THROUGH METALLIC NANOHOLE ARRAYS - The present invention presents a device and methods of use thereof in combined electrohydrodynamic concentration and plasmonic detection of a charged species of interest using a flow-through nanohole array. The device comprises microchannels, which are linked to a substrate with arrays of through nanoholes, wherein the substrate comprises two layers, wherein one of the layers is made of insulator material and one of the layers is made of metal, whereby induction of an electric field across the nanohole array results in the species of interest concentrating inside the nanoholes and in the vicinity of the nanohole arrays. The induction of an electric field is achieved by means of an external electric field source, which is applied to the fluid containing the species of interest, resulting in electroosmotic (EO) flow. An additional pressure driven fluid flow in the microchannels, co-directional to the EO flow is applied by external means. The resulting fluid flow from the combination of the EO and pressure driven flow results in a total bulk fluid flow hereafter referred to as bulk flow (BF). The local electric field strength across the insulator layer of the nanoholes is high and the charged species in the fluid may exhibit a high electrophoretic (EP) velocity, opposing the BF. The local field strength in the metallic portion of the nanoholes is null, due to the conducting nature of the metal, and the charged species in the fluid exhibits a null EP velocity in this region. The BF and the EP velocity of the charged species may be balanced which may result in the concentration of the charged species inside the nanoholes and at both sides of the nanohole array. An incident light over one side of the nanohole array may result in the formation of surface plasmons (SP) at the interface of the metal and the surrounding liquid containing the concentrated species. The signal from the SP may be detected by optical means, including surface plasmon resonance (SPR) imaging and SPR spectroscopy. | 11-22-2012 |
20120292497 | Method and Structure for Controlling Magnetic Field Distributions in an ExB Wien Filter - An ExB Wien mass filter providing a method and structure for mechanically adjusting the magnetic field distributions at the mass filter entrance and exit end caps. The reluctance of the flux return path may be modified by configuring pluralities of magnetic shims within slots at the outer diameters of the entrance and exit end caps, and also by configuring pluralities of magnetic plug shims within circular flux dams surrounding the entrance and exit apertures. Advantages of purely mechanical adjustment for the magnetic fields of the present invention, compared with prior art electromagnet adjustment methods include greater reliability, simplicity, lower cost, and lack of power dissipation. The invention may employ either permanent magnets or electromagnets for generation of the mass-separation magnetic field. | 11-22-2012 |
20120292498 | TANDEM MASS SPECTRUM ANALYSIS DEVICE AND MASS SPECTRUM ANALYSIS METHOD - A tandem mass spectrometer is provided in the present invention. The mass spectrometer includes an ion source, a quadrupole mass filter located at downstream side of the ion source, a linear ion trap disposed at downstream side of the mass filter and an ion detector placed on the side of the ion trap, all of which are placed in a vacuum environment. The instrument can obtain MS meeting the standard spectral library search criteria by the quadrupole mass filter cooperating with linear ion trap, realize any multi-stage MS under two modes of axial collision and resonance excitation, and predict and optimize the inflow amount and types of samples under the ion trap analysis mode by the quadrupole. A tandem MS analysis method is also provided, which can repeatedly provide precursor ion selection, ion acceleration, achieve high-energy collision dissociation, low product ion mass discrimination effect. | 11-22-2012 |
20120298853 | ORTHOGONAL ION INJECTION APPARATUS AND PROCESS - An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions. | 11-29-2012 |
20120298854 | Mass Analysis Variable Exit Aperture - A method and apparatus is provided for reducing unwanted isotopes of an ion implantation species from an ion beamline. The apparatus herein disclosed is a mass analysis variable exit aperture that selectively reduces the size of an exit aperture as seen by an ion beam. In one embodiment, the variable mass analysis exit aperture is located within a mass analyzer at a position upstream of a resolving aperture and effectively limits the size of an exit aperture so as to allow passage of desired implantation isotope(s) while blocking the passage of unwanted implantation isotopes. In one particular embodiment, the mass analysis variable exit aperture has a mechanical drive mechanism that enables a blocking structure to be moved into the path of an ion beam in a graduated fashion as guided by a control unit that operates based upon one or more characteristics of the ion beam. | 11-29-2012 |
20120298855 | Apparatus and Method for Time-of-Flight Mass Spectrometry - A flight-of-time mass spectrometer and method of flight-of-time mass spectrometry. The spectrometer includes a storage portion, a parameter adjusting portion, a parameter setting portion, and a flight time measuring portion. The parameter adjusting portion calculates values of an adjustment parameter correlated with any specified m/z value based on an adjustment table. The parameter setting portion sets the delayed extraction parameters of the ion source based on the values of the adjustment parameters calculated by the parameter adjusting portion. | 11-29-2012 |
20120298856 | MULTI-DOPANT PERMEATION TUBE - Aspects and embodiments of the present invention are directed to spectrometry systems and for apparatus and methods for delivering dopants to same. In one example, there is provided a dopant delivery device configured to supply dopants to a spectrometry system comprising a tube including a first chamber and a second chamber, a first dopant source included in the first chamber, and a second dopant source included in the second chamber. | 11-29-2012 |
20120298857 | Three-Dimensional Molecular Imaging By Infrared Laser Ablation Electrospray Ionization Mass Spectrometry - The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI). | 11-29-2012 |
20120298858 | METHODS OF ANALYZING COMPOSITION OF AEROSOL PARTICLES - An aerosol particle analyzer includes a laser ablation chamber, a gas-filled conduit, and a mass spectrometer. The laser ablation chamber can be operated at a low pressure, which can be from 0.1 mTorr to 30 mTorr. The ablated ions are transferred into a gas-filled conduit. The gas-filled conduit reduces the electrical charge and the speed of ablated ions as they collide and mix with buffer gases in the gas-filled conduit. Preferably, the gas filled-conduit includes an electromagnetic multipole structure that collimates the nascent ions into a beam, which is guided into the mass spectrometer. Because the gas-filled conduit allows storage of vast quantities of the ions from the ablated particles, the ions from a single ablated particle can be analyzed multiple times and by a variety of techniques to supply statistically meaningful analysis of composition and isotope ratios. | 11-29-2012 |
20120298859 | METHOD AND APPARATUS FOR REDUCING NOISE IN MASS SIGNAL - A more effective noise reduction method is provided. In the method, when mass spectrum information having a spatial distribution is processed, the whole data is taken as three-dimensional data (positional information is stored in an xy plane, and spectral information is stored along a z-axis direction), and three-dimensional wavelet noise reduction is performed by applying preferable basis functions to a spectral direction and a peak distribution direction (in-plane direction). | 11-29-2012 |
20120305758 | ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT AND SELECTION OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. | 12-06-2012 |
20120305759 | ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION AND TRAPPING OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can act as linear ion traps or Paul ion traps. | 12-06-2012 |
20120305760 | Membrane Detector for Time-of-Flight Mass Spectrometry - The invention provides methods, and related devices and device components, for detecting, sensing and analyzing analytes in samples. In some aspects, the invention provides methods, and related devices and device components, useful in combination with a mass analyzer for the mass spectrometric analysis of analytes derived from biomolecules in biological samples including biological fluids cell extracts, and cell lysates. Methods of some aspects of the invention utilize a thin membrane-based detector as a transducer for converting the kinetic energies of analytes into a field emission signal via excitation of mechanical vibrations in an electromechanically biased membrane by generation of a thermal gradient. | 12-06-2012 |
20120305761 | METHOD AND APPARATUS FOR CHEMICAL AND BIOLOGICAL SAMPLE SEPARATION - The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. Additional energy is used to enhance the mobility based separation; in particular, the energy level can be tuned. | 12-06-2012 |
20120312978 | Mass Spectrometry for Gas Analysis in Which both a Charged Particle Source and a Charged Particle Analyzer are Offset from an Axis of a Deflector Lens, Resulting in Reduced Baseline Signal Offsets - Apparatus, methods and systems are provided to inhibit a sightline from a charged particle source to an analyzer and for changing a baseline offset of an output spectrum of an analyzer. A supply of charged particles is directed through a hollow body of a deflector lens that is positioned relative to a charged particle source and an analyzer. A flow path along a preferred flow path through a deflector lens permits passage of the ions from the source to the detector while inhibiting a sightline from the detector to the source in a direction parallel to the central longitudinal axis of the deflector lens. | 12-13-2012 |
20120312979 | ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF - The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member. | 12-13-2012 |
20120312980 | Direct Sample Analysis Ion Source - A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and/or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement. | 12-13-2012 |
20120312981 | APPARATUS THAT SUPPLIES CONTENT - A search server ( | 12-13-2012 |
20120312982 | MASS SPECTROMETERS AND METHODS OF ION SEPARATION AND DETECTION - A mass spectrometer operating according to the iso-tach principle in which a mass filter accelerates ions to nominally equal velocities irrespective of their mass-to-charge ratios. The mass spectrometer is provided with an improved detector based on an electrostatic lens arrangement made of a concave lens followed in the beam path by a convex lens. These lenses deflect ions away from the beam axis by a distance from the beam axis that is inversely proportional to their mass-to-charge ratios. The mass-to-charge ratio of the ions can then be determined by a suitable detector array, such as a multi-channel plate placed in the beam path. This provides a compact and sensitive instrument. | 12-13-2012 |
20120312983 | NANO-ELECTROSPRAY IONIZATION TECHNIQUE AND DEVICE - Nano-electrospray ionization techniques include the introduction of a separation solvent containing a sample to a column-integrated needle having a column filled with a resin for liquid chromatography. The separated sample components are sprayed from the tip of the column-integrated needle toward a sample introduction orifice of a mass spectrometer. An organic solvent is simultaneously introduced to a solvent-supplying needle. The organic solvent is supplied from the tip of the solvent-supplying needle to the tip of the column-integrated needle. | 12-13-2012 |
20120318969 | METHOD FOR THE DIFFERENTIATION OF ALTERNATIVE SOURCES OF NAPHTHENIC ACIDS - A method for determining naphthenic acids derived from different sources, in particular oil sands process water by identifying particular tricyclic and pentacyclic diamondoid acids in a sample and measuring the concentration of the acids to provide a distinctive profile for a given source. | 12-20-2012 |
20120318970 | ION SELECTION OPTIMIZATION FOR MASS SPECTROMETRY - Systems and methods for mass spectrometry are presented. In one embodiment, a method for selecting a target ion and a plurality of qualifier ions for calibration of an analyte in an MS test is presented. For example, the method may include: (a) obtaining a reference spectrum for the analyte; (b) identifying an extraction time window for the reference spectrum; (c) extracting a matrix spectrum over the extraction time window; (d) measuring a noise value in a plurality of matrix ions; (e) calculating a signal-to-noise value for a plurality of analyte ions by dividing the abundance of the analyte ion by the noise value at a corresponding matrix ion; (f) assigning the target ion as the analyte ion having the highest signal-to-noise value; and (g) assigning a qualifier ion as the analyte ion with the next highest signal-to-noise value. | 12-20-2012 |
20120318971 | ANALYSIS OF TOTAL HOMOCYSTEINE AND METHYLMALONIC ACID IN PLASMA BY LC-MS/MS FROM A PLASMA SEPARATOR DEVICE (PSD) - The present invention provides a method of diagnosing multiple disorders and distinguishing there between using a plasma sample obtained from a plasma separator device and analyzing the plasma sample using an LC-MS/MS to detect at least two analyte levels in the plasma sample to diagnose one or more disorders. | 12-20-2012 |
20120318972 | MASS SPECTROMETRY APPARATUS AND METHODS - A mass spectrometer having a mass filter which applies a transient voltage profile to accelerate ion packets. The voltage profile is chosen to have a functional form which imparts each ion species with a kinetic energy which is larger the larger the mass-to- charge ratio and a velocity which is smaller the larger the mass-to-charge ratio. The ions are detected in an ion detector which discriminates between different ion species based on their kinetic energy and taking account of the functional form of the voltage profile. Suitable voltage profiles include periodic functions such as sinusoids, triangles and sawtooths, which allow the amplification of drive pulses in the mass filter to be carried out with narrow band amplification stages, which are simple and inexpensive to construct. | 12-20-2012 |
20120326019 | Method Of Mass Spectrometry - This invention comprises a method of imaging of a substrate in which a sample of interest is first ionized at multiple known positions whereafter a mass spectrum of the ionized sample at each of the multiple known positions is produced using a Mass Spectrometer. An overall spectrum for the whole sample is then created, and a number of peaks within the overall spectrum is selected. A scan distribution for at least some of the selected peaks is created, and the scan distributions are compared to identify correlations between different analytes within the sample. | 12-27-2012 |
20120326020 | Ion mobility spectrometer device with embedded faims - A tandem instrument using a variable frequency pulsed ionization source and two separation techniques, low (IMS) and high (FAIMS) field mobility is provided. The analytical stage features a field driven FAIMS cell embedded on-axis within the IMS drift tube. The FAIMS cell includes two parallel grids of approximately the same diameter as the IMS rings and can be placed anywhere along the drift tube and biased according to their location in the voltage divider ladder to create the same IMS field. The spacing between the grids constitutes the analytical gap where ions are subject, in addition to the drift field, to the asymmetric dispersive field of the FAIMS. The oscillatory motion performed during the high and low voltages of the asymmetric waveform separates the ions according to the difference in their mobilities. | 12-27-2012 |
20120326021 | Mass Spectrometry Device and Method Using Ion-Molecule Reaction Ionization - A mass spectrometer that performs ion-molecule reaction ionization and accurately performs qualitative/quantitative analysis on a sample containing multi-components for a short time is achieved without an increase in the size of the device. A plurality of ion sources ( | 12-27-2012 |
20120326022 | MASS SPECTROMETER AND MASS ANALYZING METHOD - A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput | 12-27-2012 |
20120326023 | ION MOBILITY SPECTROMETER to MASS SPECTROMETER INTERFACE - A method and apparatus are described herein for the interface of an ion mobility spectrometer (IMS) to a mass spectrometer (MS) that utilizes collisional focusing, through internal modification. Commercial standalone IMS instrumentation cannot be combined in tandem with a commercially available MS that utilizes collisional focusing due to the physics of the differentially pumped interface of the MS being an unsuitable environment for an IMS measurement. The invention provides for transfer of the ion beam from the IMS to the MS without distortion of the chemical species or temporal profile due to large scale collisions in the differentially pumped interface, by increasing the electric field strength between the orifice and skimmer, and decreasing the pressure in the differentially pumped interface, thereby reducing the number of background gas collisions encountered by the ion beam during transit from the IMS to the MS. | 12-27-2012 |
20120326024 | Detection Method for an Ion Migration Spectrum and an Ion Migration Spectrometer Using the Same Method - A detection apparatus and method for an ion migration spectrum include acquiring an ion migration spectrum of pure carrier gas and an ion migration spectrum of carrier gas containing a test substance sample and performing differential process on the ion migration spectrum of the pure carrier gas and the ion migration spectrum of the carrier gas containing the test substance sample to acquire a differential spectrum. The value of a characteristic peak of the differential spectrum represents properties of the sample of substances. The method avoids interferences on the migration spectrum from interference sources of the apparatus itself, thereby improving detection sensitivity and accuracy of the ion migration spectrum, and migration spectrum shift caused by variations in the environmental conditions can be found and corrected through the differential process on the migration spectrum of the pure carrier gas, thereby achieving self-stableness and self-correction of the ion migration spectrometer. | 12-27-2012 |
20120326025 | DIAGNOSING PROSTATE CANCER RELAPSE - The invention discloses the use of at least one substance selected from the group consisting of Phosphatidylcholine with diacyl residue sum C24:0 (PC aa C24:0); Phosphatidylcholine with diacyl residue sum C40:3 (PC ae C40:3); Phosphatidylcholine with diacyl residue sum C40:4 (PC ae C40:4); Lysophosphatidylcholine with acyl residue sum C26:0 (lysoPC a C26:0); Lysophosphatidylcholine with acyl residue sum C6:0 (lysoPC a C6:0); 13(S)-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE); 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12S-HETE); 15(S)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15S-HETE); Leukotriene B4 (LTB4); Prostaglandin E2 (PGE2); Prostaglandin D2 (PGD2); 7α-Hydroxycholesterol (7aOHC); 7-Ketocholesterol (7KC); 5β,6β-Epoxycholesterol (5b,6b,EPC); 5g302,6g302-Epoxycholesterol (5a,6a,EPC); and 4β-Hydroxycholesterol (4BOHC); for prognosticating relapse of a prostate cancer (PCa) in a sample of a body fluid or a tissue sample of a PCa patient. | 12-27-2012 |
20130001414 | SYSTEM AND METHOD FOR PRODUCING A MASS ANALYZED ION BEAM FOR HIGH THROUGHPUT OPERATION - A system for producing a mass analyzed ion beam for implanting into a workpiece, includes an extraction plate having a set of apertures having a longitudinal axis of the aperture. The set of apertures are configured to extract ions from an ion source to form a plurality of beamlets. The system also includes an analyzing magnet region configured to provide a magnetic field to deflect ions in the beamlets in a first direction that is generally perpendicular to the longitudinal axis of the apertures. The system further includes a mass analysis plate having a set of apertures configured to transmit first ion species having a first mass/charge ratio and to block second ion species having a second mass/charge ratio and a workpiece holder configured to move with respect to the mass analysis plate along the first direction. | 01-03-2013 |
20130009051 | ABRIDGED ION TRAP - TIME OF FLIGHT MASS SPECTROMETER - An improved trap-TOF mass spectrometer has a set of electrodes arranged to produce both a quadrupolar RF confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the RF field and then, at a selected time, the RF confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a TOF MS analysis. The apparatus of the present invention may be used alone or in conjunction with other analyzers to produce mass spectra from analyte ions. | 01-10-2013 |
20130009052 | MASS SPECTROMETRY SYSTEMS - Described herein are methods that may be used related to mass spectrometry, such as mass spectrometry analysis, mass spectrometry calibration, identification of proteins/peptides by mass spectrometry and/or mass spectrometry data collection strategies. In one embodiment, the subject matter discloses a phase-modeling analysis method for identification of proteins or peptides by mass spectrometry. | 01-10-2013 |
20130009053 | PRACTICAL ION MOBILITY SPECTROMETER APPARATUS AND METHODS FOR CHEMICAL AND/OR BIOLOGICAL DETECTION - This invention describes an ion mobility spectrometer and operational methods for chemical analysis. The ion mobility spectrometer allows for continuous operation and rapid temperature control to reach designed operational conditions, as well as analysis under a temperature gradient. | 01-10-2013 |
20130009054 | DEVICE AND METHOD FOR DIRECT MEASUREMENT OF ISOTOPES OF EXPIRED GASES - The invention provides a device including a chamber wherein the chamber including a rigid enclosure; a rigid lid for the enclosure; a gasket between the lid and the enclosure to allow for an airtight seal between the enclosure and the gasket upon closure of a latch connecting the enclosure and the lid; a port for airtight attachment of a syringe, and a port for airtight insertion of a gas sensor. The device can further include a gas sensor and one or more syringes for attachment to the device by a three-way stopcocks. The device is appropriately sized for use with the subject of interest. The invention also provides methods for use of the device. | 01-10-2013 |
20130015342 | Fixed Connection Assembly For an RF Drive Circuit in a Mass SpectrometerAANM Steiner; UrsAACI BranfordAAST CTAACO USAAGP Steiner; Urs Branford CT USAANM Jones; Lawrence B.AACI San JoseAAST CAAACO USAAGP Jones; Lawrence B. San Jose CA US - In one embodiment, a mass spectrometer includes an RF drive circuit for generating RF signals, a quadrupole mass filter, and a fixed connection assembly for delivering RF signals from the RF drive circuit to the quadrupole mass filter, the fixed connection assembly representing the entire delivery path of RF signals from the RF drive circuit to the quadrupole mass filter. By avoiding flexible components such as a freestanding wires or flexible circuit boards, the need for retuning when parts are removed or disturbed for testing or servicing is reduced, and a modular instrument in which components and connections are standardized and therefore interchangeable is realized. | 01-17-2013 |
20130015343 | Radio Frequency Voltage Temperature StabilizationAANM Steiner; UrsAACI BranfordAAST CTAACO USAAGP Steiner; Urs Branford CT USAANM Jones; Lawrence B.AACI San JoseAAST CAAACO USAAGP Jones; Lawrence B. San Jose CA US - A temperature-regulated radio frequency management system for use in a mass spectrometer is described. The temperature-regulated radio frequency management system having one or more radio frequency components disposed in a vacuum environment. The temperature-regulated radio frequency management system including a radio frequency detection circuit configured to provide feedback indicative of a radio frequency signal in one or more of the radio frequency components. In addition, the temperature-regulated radio frequency management system includes a temperature regulation circuit disposed in the vacuum environment and configured to reduce temperature-induced variations in the detection circuit. | 01-17-2013 |
20130015344 | BACKGROUND NOISE CORRECTION IN QUADRUPOLE MASS SPECTROMETERS - In a quadrupole mass spectrometer, which measures ion currents of a single mass with substantially constant RF and DC voltages during a measuring period and measures ions of different masses by varying the RF and DC voltages, a statistical evaluation is performed during data acquisition by a determination of the distribution of the measured and digitized noise values around an average noise level in the mass spectrometer output signal. The determined noise levels are subtracted from the signal output values separately for each measurement period. | 01-17-2013 |
20130015345 | Plume Collimation for Laser Ablation Electrospray Ionization Mass Spectrometry - In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described. | 01-17-2013 |
20130015346 | Detection and Quanitation of Pain Medications in Oral Fluid Specimens - A method for the detection and quantitation of pain medication in oral fluid specimens is provided. First, a Solid Phase Extraction (“SPE”) process is used to isolate cocaine and its metabolite, amphetamines and/or butalbital from human oral fluid samples. Alternatively, Liquid-Liquid Extraction (“LLE”) is used to isolate methadone and its metabolite, fentanyl and norfentanyl, buprenorphine and norbuprenorphine, propoxyphene and norpropoxyphene, carisoprodol, meprobamate, a series of benzodiazepines, tramadol and its metabolites, the analgesic opioids, and tetrahydrocannabinol (“THC”) and its carboxylated metabolite (“THC-C”). Finally, following isolation of these drugs and their metabolites, they are separated respectively using a high performance liquid chromatographic column and a novel combination chromatographic solvents and gradients. All analytes are detected and quantified using a tandem mass spectrometry (“MS/MS”) precursor to produce ion transitions. | 01-17-2013 |
20130020481 | Collision Cell - A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. | 01-24-2013 |
20130020482 | METHOD FOR ENHANCEMENT OF MASS RESOLUTION OVER A LIMITED MASS RANGE FOR TIME-OF-FLIGHT SPECTROMETRY - Novel methods and instrumentation for mass spectrometry are described. Zoom-time of flight mass spectrometry (Zoom-TOF) allows increased mass resolution over a pre-determined specific range of masses. Methods for retrofitting traditional time-of-flight (TOF) and distance of flight (DOF) mass spectrometers are described, as well as novel instruments capable of performing Zoom-TOF analyses. | 01-24-2013 |
20130026357 | INTEGRATED ION MOBILITY SPECTROMETER - An ion mobility spectrometer includes a plurality of substrates defining a measurement region for receiving a singular laminar gas flow without any carrier or sheath gas. The measurement region includes an ionization region that is continuous with a detection region. An ionizing electrode, which may include a plurality of asymmetric electrodes, produces ions in the gas sample within the ionization region. The ionizing electrode may apply a time varying voltage to the gas sample to generate a time dependent ion production. A field generating electrode generates an electric field to deflect the ions in the gas sample, and a detection electrode array detects the deflected ions within the detection region. A controller is configured to determine ion species based on the detection of ions by the detection electrode array. The detection electrode array may include a plurality of detection electrodes, and the controller may be configured to differentiate ion species based on which ions are detected by which one of the detection electrodes | 01-31-2013 |
20130026358 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 01-31-2013 |
20130032709 | STEP-SCAN ION TRAP MASS SPECTROMETRY FOR HIGH SPEED PROTEOMICS - An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position. | 02-07-2013 |
20130037706 | Devices and methods for cryo lift-out with in situ probe - Cryogenic manipulation of a material sample with an in situ probe is enabled with a novel cooled probe design. A material sample mounted on a cryo-stage in a vacuum chamber is cooled to a cryogenic temperature. In addition, a nano-manipulator probe inside the sample chamber is also cooled to cryogenic temperature. A specific sample site is milled in the chamber using a focused ion beam and attached to the cooled probe by vapor deposition. After releasing the sample, the sample site is attached to a destination surface such as a transmission electron microscope (TEM) grid and the probe is then detached from the sample using the focused ion beam. | 02-14-2013 |
20130037707 | MEASUREMENT OF ISOTOPE RATIOS IN COMPLEX MATRICES - The present techniques are directed to a method for microprobe analyses of isotope ratios in inhomogeneous matrices. The method includes selecting matrix standards that have matrices that resemble a target matrix. A bulk isotope analysis is run on each of the matrix standards to determine a bulk isotope ratio value. A microprobe analysis is run on each of the matrix standards to determine a microprobe isotope ratio values for each of the plurality of matrix standards. Spurious values are eliminated from the microprobe isotope ratio values. The microprobe isotope ratio values are averaged for each of the matrix standards to create an average microprobe isotope ratio value associated with each of the matrix standards. The bulk isotope ratio value for each of matrix standards is plotted against the average microprobe isotope ratio value associated with each of the matrix standards to create a matrix corrected calibration curve. | 02-14-2013 |
20130037708 | POLYACRYLIC ACID (SALT), POLYACRYLIC ACID (SALT)-BASED WATER-ABSORBING RESIN, AND PROCESS FOR PRODUCING SAME - Disclosed are a polyacrylate (salt) and a polyacrylate (salt) water-absorbent resin containing a tracer which can be verified back to the manufacturing process of the water-absorbent resin when dealing with various problems with the water-absorbent resin which can occur from the manufacturing process of the water-resistant resin, during the use thereof by a consumer, up until the disposal thereof. The disclosed polyacrylate (salt) and the polyacrylate (salt) water-absorbent resin have a carbon stable isotope ratio (δ | 02-14-2013 |
20130037709 | Method for Clinically Monitoring Niacin and Niacin Metabolites in Serum or Plasma - The present invention provides methods for determining the amount of nicotinic acid and its active metabolites in a biological sample using mass spectrometry. The methods involve specific sample collection processes necessary to stabilize and facilitate simultaneous analysis of nicotinic acid and active metabolites. Once in the laboratory, sample preparation is followed by solid phase extraction, liquid chromatographic separation of relevant moieties with detection by MS/MS whereby specific ion transitions are monitored. This invention has several clinical utilities, particularly those related to monitoring patients on antihyperlipidemic drug therapy. | 02-14-2013 |
20130043382 | MULTIPOLE ION GUIDE OPERATING AT ELEVATED PRESSURES - A device and method for transporting ions along a longitudinal direction in an elevated gas pressure region. The device includes a multipole ion guide having a set of rods positioned along the longitudinal direction on an inscribed diameter equal to or less than 3.5 mm, a voltage source which provides alternating voltages to at least a subset of the rods to create a trapping field in a transverse direction, and a conductance limit having an opening d and placed at the exit of the multipole ion guide. At the end of this configuration near the opening of the conductance limit, a converging continuum gas flow through the conductance limit is provided that transfers the ions collimating near a center of the ion guide into a low gas pressure region. The method injects ions into the elevated gas pressure region of the ion guide, and transports the ions in the converging continuum gas flow into the low gas pressure region. | 02-21-2013 |
20130043383 | Methods of Determining Polydispersity and/or Molecular Weight Distribution of a Polyethylene Glycol Sample - Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis. | 02-21-2013 |
20130043384 | POLYACRYLIC ACID (SALT), POLYACRYLIC ACID (SALT)-BASED WATER-ABSORBING RESIN, AND PROCESS FOR PRODUCING SAME - A polyacrylic acid (salt), or a polyacrylic acid (salt)-based water-absorbing resin, contains a tracer for detecting various troubles in the water-absorbing resin during the period from the production of the water-absorbing resin to the use and discard thereof by a consumer. The polyacrylic acid (salt)-based water-absorbing resin has a stable carbon isotope ratio, as determined by accelerator mass spectrometry, of less than −20% and a radioactive carbon content of 1.0×10 | 02-21-2013 |
20130043385 | Apparatus and Method for a Multi-Stage Ion Transfer Tube Assembly for Use with Mass Spectrometry - An apparatus and method for introducing ions into a vacuum chamber of a mass spectrometer includes producing ions in an ionization chamber of an ion source. The ions are sampled into an intermediate pressure chamber via a first ion transfer tube. In particular, the pressure within the intermediate pressure chamber is maintained at a value that exceeds a maximum pressure for being sampled into the vacuum chamber of the mass spectrometer. Some of the ions are sampled from the intermediate pressure chamber via at least a second ion transfer tube, the at least a second ion transfer tube having an outlet end that is in communication with a low-pressure chamber. In particular, the pressure within the low-pressure chamber is maintained at a value that is less than a maximum pressure for being sampled into the vacuum chamber of the mass spectrometer. Some of the ions are sampled from the low-pressure chamber into the vacuum chamber of the mass spectrometer. | 02-21-2013 |
20130048851 | MASS SPECTROMETER AND MASS ANALYZING METHOD - A mass spectrometer for efficiently ionizing a sample with less carry-over. The ratio of the amount of sample gas to that of a whole headspace gas is increased by decreasing the pressure inside of a sample vessel in which the sample is sealed thereby efficiently ionizing the sample. | 02-28-2013 |
20130048852 | Electrostatic Mass Spectrometer with Encoded Frequent Pulses - A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E-trap sensitivity. | 02-28-2013 |
20130056627 | Open Trap Mass Spectrometer - An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets. Using reproducible distribution of relative intensity within multiplets, the signal can be unscrambled for relatively sparse spectra, such as spectra past fragmentation cell of tandem mass spectrometer, past ion mobility and differential ion mobility separators. Various embodiments are provided for particular pulsed ion sources and pulsed converters such as orthogonal accelerators, ion guides, and ion traps. The method and apparatus enhance the duty cycle of pulsed converters, improve space charge tolerance of the open trap analyzer and extends the dynamic range of time-of-flight detectors. | 03-07-2013 |
20130056628 | LASER SPOT CONTROL IN MALDI MASS SPECTROMETERS - Mass spectrometers ionize samples by matrix-assisted laser desorption (MALDI). The samples are located on a moveable support plate, and irradiated by a pulsed laser. A fast positional control of laser spots is provided via a system of rotatable mirrors to relieve strain on a support plate motion drive. If the spot position is finely adjusted by the mirror system and follows the movement of the sample support plate, the intermittent movement of the sample support can be replaced with a continuous uniform motion. The fast positional control allows more uniform ablation of a sample area. Galvo mirrors with low inertia may be used between the beam generation and a Kepler telescope in the housing of the laser. The positional control can also provide a fully automatic adjustment of MALDI time-of-flight mass spectrometers, at least if the ion-optical elements are equipped with movement devices. | 03-07-2013 |
20130056629 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. | 03-07-2013 |
20130056630 | DETECTION AND MONITORING OF NONALCOHOLIC FATTY LIVER DISEASE - A method of assessing the severity of nonalcoholic fatty liver disease nonalcoholic steatohepatitis, and/or liver fibrosis in a subject includes obtaining a bodily sample from a subject and determining a level of the at least one oxidized fatty acid product in the sample. An increased level of at least one oxidized fatty acid product in the subject compared to a control is indicative of an increase in severity of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and/or liver fibrosis. | 03-07-2013 |
20130056631 | TECHNIQUES FOR AUTOMATED PARAMETER ADJUSTMENT USING ION SIGNAL INTENSITY FEEDBACK - Described are techniques for tuning parameters of a system. For one or more values of a distance, mass spectral analysis of a liquid analyte stream is performed. A corresponding ion signal intensity of a selected ion is obtained. The distance is measured from a first end of a first tube to a second end of a second tube which surrounds said first tube. Using a computing device, a current value of the distance is automatically adjusted in accordance with corresponding ion signal intensities obtained for the selected ion. Using a computing device, a desired value for the distance is automatically determined using the corresponding ion signal intensities. The desired value results in an ion signal intensity for the selected ion which is any of more than a threshold intensity and a maximum of ion signal intensities obtained by performing mass spectral analysis using different values for the distance. | 03-07-2013 |
20130062515 | IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS - In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. | 03-14-2013 |
20130062516 | DIGANOSIS OF A RENAL DISEASE BY OXYGEN AND HYDROGEN ISOTOPES IN A BIOLOGICAL SAMPLE - The invention provides a method for diagnosing likelihood of a renal disease in a subject suspected of the renal disease, comprising: measuring a value of delta O-18 (δ | 03-14-2013 |
20130062517 | ACCELERATED HIGH RESOLUTION DIFFERENTIAL ION MOBILITY SEPARATIONS USING HYDROGEN CARRIER GAS - A new carder gas medium for differential or field asymmetric waveform on mobility spectrometry (FAIMS) is disclosed. Separations in this medium generally follow those in He/N | 03-14-2013 |
20130062518 | Mass Spectrometry Detector System and Method of Detection - Methods and analyzers useful for time of flight mass spectrometry are provided. A method of determining properties of ions within a time of flight or electrostatic trap mass analyzer comprises the steps of: injecting ions into the mass analyzer; causing the ions to follow a portion of a main flight path within the mass analyzer, the main flight path comprising multiple changes of direction; applying a beam deflection to deflect at least some of the ions from the main flight path so that they impinge upon a detection surface located within the mass analyzer, the detection surface comprising part of an active field-sustaining electrode of the mass analyzer; measuring a quantity representative of the charge arriving at the detection surface caused by the impinging ions; determining, from the deflection applied, properties of a trajectory upon which the ions were travelling immediately prior to deflection, and/or determining, from the quantity measured, a value representative of the number of the ions that impinged upon the detector surface; and wherein the analyzer utilises an analyzer field, the detection surface sustains the analyzer field in its vicinity, and the analyzer field in the vicinity of the detection surface is substantially non-zero. | 03-14-2013 |
20130068942 | Ion Trap Mass Spectrometer - Electrostatic trap mass spectrometers are disclosed that may comprise at least two parallel sets of electrodes separated by a field-free space, wherein said at least two parallel electrode sets extend along a curved Z-direction locally orthogonal to said X-Y plane such that each of said two electrode sets define a volume with a two-dimensional electrostatic field in an X-Y plane and define either planar or torroidal field regions; means for adjusting the torroidal field regions to provide both (i) stable trapping of ions passing between said fields within said X-Y plane and (ii) isochronous repetitive ion oscillations within said X-Y plane such that the stable ion motion does not require any orbital or side motion; and an ion bounding means in the curved Z-direction configured to compensate time-of-flight distortions at Z-edges of the trap. | 03-21-2013 |
20130068943 | General Mass Spectrometry Assay Using Continuously Eluting Co-Fractionating Reporters of Mass Spectrometry Detection Efficiency - The invention provides general methods for quantifying any conceivable compound including small organic molecules and biological molecules in mass spectrometric measurements. The methods include the use of chemical or biological reporters such as artificial polypeptides containing proteolytic cleavage sites, which provide proteolytic reporter peptides for standardization of mass spectrometric detection efficiency. In addition to mass spectrometry standardization between different samples, the artificial polypeptides also standardize sample preparation amongst different samples undergoing mass spectrometric analysis when using electrophoresis separation prior to mass spectrometric analysis. Methods of the present invention also include methods for designing artificial polypeptides with peak to peak continuous liquid chromatography elution profiles spanning the complete or partial analyte elution profile for organic and biological molecules. Also included are the artificial polypeptides predigested with protease, which is compatible for use in experiments with native PAGE, in-solution proteolytic digestion of polypeptides, and small organic molecules undergoing fractionation separation followed by mass spectrometric evaluation. | 03-21-2013 |
20130068944 | Control Of Ions - A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means. | 03-21-2013 |
20130068945 | METHOD FOR DETERMINING STAGE OF CHRONIC KIDNEY DISEASE, DEVICE THEREFOR AND METHOD FOR OPERATING THE SAME - This invention provides a method or device for determining the stage of chronic kidney disease. | 03-21-2013 |
20130075601 | WIND ION NEUTRAL COMPOSITION APPARATUS - Embodiments of the present invention pertain to an apparatus that provides four simultaneous ion and neutral measurements as a function of altitude with variable sensitivity for neutral atmospheric species. The variable sensitivity makes it possible to extend the measurements over the altitude range of 100 to more than 700 kilometers. The four instruments included in the apparatus are a neutral wind-temperature spectrometer, an ion-drift ion-temperature spectrometer, a neutral mass spectrometer, and an ion mass spectrometer. The neutral wind-temperature spectrometer and ion-drift ion-temperature spectrometer are configured to separate O and N | 03-28-2013 |
20130087700 | DIRECT IMPACT IONIZATION (DII) MASS SPECTROMETRY - Disclosed is a mass spectrometer for analyzing a sample that has or is suspected of having microorganisms. The disclosed mass spectrometer has been uniquely configured to include a sample platform which functions as a counter electrode or discharge electrode and a surface to provide the sample to be analyzed. The mass spectrometer also includes an ion source positioned adjacent to the sample platform for ionizing and volatizing molecules within the sample, wherein the sample platform and the ion source are positioned such that during operation of the mass spectrometer an electrical discharge takes place between the ion source and the sample platform. Also disclosed are methods for generating a mass spectrum profile/fingerprint of a sample. The methods include positioning a sample platform having a sample adjacent to an ion source. | 04-11-2013 |
20130087701 | SYSTEMS AND METHODS FOR REDUCING NOISE FROM MASS SPECTRA - A plurality of scans of a sample are performed, producing a plurality of mass spectra. Neighboring mass spectra of the plurality of mass spectra are combined into a collection of mass spectra based on sample location, time, or mass. A background noise estimate is calculated for the collection of mass spectra. The collection of mass spectra is filtered using the background noise estimate, producing a filtered collection of one or more mass spectra. Quantitative or qualitative analysis is performed using the filtered collection of one or more mass spectra. The background noise estimate is calculated by dividing the collection of mass spectra into two or more windows, for example. For each window of the two or more windows, all spectra within each window are combined, producing a combined spectrum for each of the two or more windows. For each combined spectrum, a background noise is estimated. | 04-11-2013 |
20130099110 | Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto - An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order. | 04-25-2013 |
20130099111 | TOF Mass Analyser With Improved Resolving Power - A time of flight analyser that comprises a pulsed ion source; a non-linear ion mirror having a turn-around point; and a detector. The pulsed ion source is configured to produce an ion pulse travelling along an ion flight axis, the ion pulse comprising an ion group consisting of ions of a single m/z value, the ion group having a lateral spread. The non-linear ion mirror is configured to reflect the ion group, at the turn-around point, along the ion flight axis towards the detector, the passage of the ion group through the non-linear ion mirror causing a spatial spread of the ion group. The time of flight mass analyser has at least one lens positioned between the ion source and the ion mirror, wherein the or each lens is configured to reduce said lateral spread so as to provide a local minimum of lateral spread within the ion mirror. | 04-25-2013 |
20130099112 | MASS SPECTROMETER WITH MALDI LASER SYSTEM - The invention relates to a mass spectrometer comprising a laser system for mass-spectrometric analyses with ionization of analyte molecules in a sample by matrix-assisted laser desorption. A mass spectrometer with a pulsed UV laser system produces a spatially distributed spot pattern with peaks of uniform energy density on the sample, increasing thereby the degree of ionization for analyte ions as compared to conventional spot patterns. The spot pattern with peaks of uniform energy density can be produced by homogeneous illumination of a pattern generator, for example a lens array. The homogeneous illumination can be generated by a low-cost beam-shaping element, which does not act on the UV beam but on the original infrared beam, in conjunction with changes to the beam cross-section and beam profile brought about by the nonlinear conversion crystals. This beam shaping not only produces a beam profile which illuminates the pattern generator homogeneously with low losses, but at the same time increases the efficiency of the frequency multiplication and the lifetime of the conversion crystals so that cost savings are achieved because less laser energy is required and the lifetime is increased. | 04-25-2013 |
20130099113 | IN-SITU CONDITIONING IN MASS SPECTROMETER SYSTEMS - In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream. | 04-25-2013 |
20130105681 | Ion Interface Device Having Multiple Confinement Cells And Methods Of Use Thereof | 05-02-2013 |
20130105682 | TECHNIQUES FOR EFFICIENT FRAGMENTATION OF PEPTIDES | 05-02-2013 |
20130105683 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE | 05-02-2013 |
20130105684 | ANALYTE MASS SPECTROMETRY QUANTITATION USING A UNIVERSAL REPORTER | 05-02-2013 |
20130112862 | SYSTEM AND METHOD FOR DILUTION OF A SAMPLE FOR INTRODUCTION TO A QUANTITATIVE ANALYSIS APPARATUS - A system for insitu dilution of a sample followed by volume reduction prior to introduction to a quantitative analysis apparatus. The system includes a first inlet for introducing the sample to the system, a second inlet for flow of a diluent introduced into the system separate of the sample, a mixing chamber in fluid connection with the first and second inlets for receiving and mixing the sample and the diluent in a common flow path to provide a solution, and a separator to accomplish volume reduction and for separating a portion of the solution for introduction into the analysis apparatus from a remainder of the solution. | 05-09-2013 |
20130112863 | GENERATION OF HARMONICS IN OSCILLATION MASS SPECTROMETERS - The invention relates to measuring cells and measuring methods in oscillation mass spectrometers in which clouds of the same species of ion oscillate harmonically in a potential well in a longitudinal direction, decoupled from their motion transverse to this direction. A frequency analysis of the longitudinal oscillations of these ion clouds, which is carried out by a Fourier analysis of the induced image currents between two detection electrodes, leads to frequency spectra of the ions and hence to mass spectra. The position of the ion trajectories relative to the detection electrodes and the design of the measuring cells in the oscillation mass spectrometers is used to generate large proportions of harmonics in the image currents, and evaluate the frequency signals of the harmonics. The frequency signals of these harmonics have a higher resolution in the frequency spectrum (and hence in the mass spectrum), and allow resolution of the signals from ionic species of very similar mass which are not resolved in the fundamental oscillation. The accuracy of the mass determination increases proportionally | 05-09-2013 |
20130112864 | CONTROLLER AND CONTROL METHOD FOR IMPROVING SIGNAL PERFORMANCE OF ION CYCLOTRON RESONANCE MASS SPECTROMETER - Provided are a controller and a control method for improving signal performance of an ion cyclotron resonance mass spectrometer. The controller and control method apply electric signals for causing ions injected into an ion trap of the ion cyclotron resonance mass spectrometer to be injected to the center of the trap as close as possible to trap electrodes, and adjust biased ion motion by appropriately adjusting signals of trap electrodes for causing the injected ions to make ion motion, thereby improving the fidelity of ion signals. The control method for improving signal performance of an ion cyclotron resonance mass spectrometer includes an ion position adjustment process and an ion signal detection process. | 05-09-2013 |
20130112865 | Method of Avoiding Space Charge Saturation Effects In An Ion Trap - A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects. | 05-09-2013 |
20130112866 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-09-2013 |
20130112867 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-09-2013 |
20130112868 | ION DETECTION ARRANGEMENT - A mass spectrometer is disclosed having a mass analyser with a mass-to-charge dispersive element for separating ions according to their mass-to-charge ratios along a dispersive plane and an ion deflector to deflect ions leaving the mass analyser in the dispersive plane. A shielding arrangement, located between the dispersive element and the ion deflector is arranged to define the portion of the beam to be deflected by the ion deflector. The deflected beam is steered onto a beam defining aperture, located at the focal plane of the mass analyser is detected by at least one ion detector, located downstream from the beam defining aperture. | 05-09-2013 |
20130119247 | Mass Spectrometer - A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. | 05-16-2013 |
20130119248 | METHODS AND APPARATUSES FOR PRODUCING MASS SPECTRUM DATA - The present invention is concerned with methods and apparatuses for generating mass spectrum data using a mass spectrometer by subtracting noise mass spectrum data representative of noise in the mass spectrometer from signal mass spectrum data representative of the mass/charge ratio of ions in a sample material. This produces a modified signal mass spectrum data representative of the mass/charge ratio of ions in the sample material. The method includes acquiring and subtracting noise mass spectrum data representative of noise in the mass spectrometer or alternatively subtracting noise mass spectrum data from a previously acquired or pre-stored noise spectrum data. Embodiments demonstrate reduced noise and in particular reduced systematic noise compared with the originally acquired signal mass spectrum data. | 05-16-2013 |
20130119249 | METHOD AND A MASS SPECTROMETER AND USES THEREOF FOR DETECTING IONS OR SUBSEQUENTLY-IONISED NEUTRAL PARTICLES FROM SAMPLES - A method is used in a time-of-flight mass spectrometer for analysis of a first pulsed ion beam, the ions of which are disposed along the pulse direction, separated with respect to their ion masses. The ions of at least one individual predetermined ion mass or of at least one predetermined range of ion masses can be decoupled from the first pulsed ion beam, as at least one decoupled ion beam, and the first ion beam and the at least one decoupled ion beam are analyzed. | 05-16-2013 |
20130126719 | Gas chromatography-mass spectrometry method and gas chromatography-mass spectrometry apparatus therefor having a capture and release device - A GC-MS method is provided with installing a sample injector; installing a heart-cutting unit; installing a first capillary column; connecting a switching valve to the heart-cutting unit; installing a capture and release device to the heart-cutting unit; connecting the capture and release device to the switching valve; connecting the switching valve to an MS; rotating the switching valve to either connect the first and second interconnecting columns, or connect the second capillary column and the second interconnecting column; injecting the sample gas into the first capillary column; by setting a time slot and carrier gas pressure of the heart-cutting unit, while causing fractions of simple compounds to be cut out and travel to the MS, causing fractions of complex compounds to be cut out; after the simple compounds finished in MS, causing complex compounds to be released from the capture and release device; and sending the compounds. | 05-23-2013 |
20130126720 | Method of switching ports of a switching valve of a gas chromatography-mass spectrometry apparatus - A method of operating a switching valve of a GC-MS apparatus is provided with installing a sample injector; connecting a first capillary column downstream of the sample injector; installing a heart-cutting unit downstream of the first capillary column; installing a first interconnecting column and a second capillary column to the heart-cutting unit respectively; connecting a switching valve to the heart-cutting unit via a first interconnecting column and a second capillary column respectively wherein the switching valve includes a plurality of ports; connecting the switching valve to an MS via a second interconnecting column; and switching ports to create different sample loops for passing compounds from the heart-cutting unit to the MS or passing compounds from the heart-cutting unit to the discharge column to be purged. | 05-23-2013 |
20130126721 | Measurement Of 25-Hydroxyvitamin D3 And C3 EP1-25-Hydroxyvitamin D3 - The invention describes a method of quantification of an analyte selected from the group consisting of 25-hydroxyvitamin D3 and C3-epi-25-hydroxyvitamin D3 in a specimen containing the analyte; comprising the steps of subjecting the specimen to UPLC reverse-phase separation; and; detecting the protonated precursor pseudo-molecular ion of the analyte using a mass spectrometry technique to determine the amount of the analyte. | 05-23-2013 |
20130126722 | Means and Methods for Metabolic Differentiation of Non-Alcoholic Steatohepatitis From Liver Disease - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing a liver disease in a subject and a method of differentiating between NASH and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 05-23-2013 |
20130126723 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 05-23-2013 |
20130126724 | Electrostatic Trap - An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 n radians over an ion detection period T | 05-23-2013 |
20130126725 | Analyses of Analytes by Mass Spectrometry with Values in at Least 3 Dimensions - A method for analysis of analytes in a sample and to the use of such a method and a method for monitoring progress, or treatment of a disease such as fat-related disease. These analysis methods include the steps of providing the sample, measuring of values of analytes in the sample, calculating of values based on the measured values, identifying and optionally visualizing analytes can particularly be used for monitoring quantitative changes of analytes and for monitoring progress or treatment of a disease such as a fat-related disease. | 05-23-2013 |
20130134305 | POST-IONIZATION OF NEUTRALS FOR ION MOBILITY oTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES - The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments. | 05-30-2013 |
20130140449 | METHODS FOR DETECTING REVERSE TRIIODOTHYRONINE BY MASS SPECTROMETRY - Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample. | 06-06-2013 |
20130140450 | Inductively-Coupled Plasma Ion Source for Use with a Focused Ion Beam Column with Selectable Ions - An inductively coupled plasma source having multiple gases in the plasma chamber provides multiple ion species to a focusing column. A mass filter allows for selection of a specific ion species and rapid changing from one species to another. | 06-06-2013 |
20130140451 | GENE DETECTING METHODS WITHOUT USING PCR - Gene detecting methods without using PCR are disclosed. The methods comprise forming sandwich complexes by target genes with nano-probes and capture probes, wherein nano-probes are modified with recognition molecules and magnetic microparticles modified with capture molecules; then separating the sandwich complexes; releasing the nano-probes; and detecting molecular ion peaks of encoding molecules on the surface of nano-probes by mass spectrometric detection directly, characterized in that the proportions of recognition molecules and encoding molecules on the nano-probes are 300-2000:1. | 06-06-2013 |
20130140452 | MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 06-06-2013 |
20130140453 | MASS SPECTROMETER WITH SOFT IONIZING GLOW DISCHARGE AND CONDITIONER - An ion source ( | 06-06-2013 |
20130146759 | SYSTEMS AND METHODS FOR SAMPLE ANALYSIS - The invention generally relates to improved sensitivity and flexibility for mass spectrometers with limited pumping capacity, particularly mass spectrometers that are coupled with a Discontinuous Atmospheric Pressure Interface (DAPI). | 06-13-2013 |
20130153759 | METHODS FOR EVALUATING FUEL COMPOSITIONS - Methods for evaluating a fuel are provided. In one embodiment, a method of evaluating a fuel includes providing a testing specimen of the fuel. Also, the method includes analyzing the testing specimen and identifying a compound in the testing specimen. The method also provides for determining the fuel is biologically-sourced based on the identified trace compound. | 06-20-2013 |
20130153760 | METHOD FOR ANALYZING STRUCTURE OF SUBSTANCE - A method for analyzing a structure of a substance of interest uses triple-quadrupole mass spectrometry (TQ-MS), and allows for acquisition of MS | 06-20-2013 |
20130153761 | Systems and Methods for Using Variable Mass Selection Window Widths in Tandem Mass Spectrometry - Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample. | 06-20-2013 |
20130153762 | METHOD AND APPARATUS FOR IONIZING GASES USING UV RADIATION AND ELECTRONS AND IDENTIFYING SAID GASES - The invention relates to a method for ionizing and identifying gases, wherein the gases to be identified are ionized in a reaction chamber and the product ions are measured, wherein the measurement of the product ions takes place via electrical fields acting on the product ions and the detection is performed with a detector for ions. It is provided that ionization takes place via UV radiation, and that simultaneously or sequentially ionization by electrons takes place. The invention further relates to a device for ionizing and identifying gases, which includes an ion source chamber having an ion source and an ion mobility spectrometer. For this purpose, a partition between the ion source chamber and the ion mobility spectrometer has a UV-transparent window and a window permeable for electrons, wherein UV radiation and electron radiation can be generated in the ion source chamber with the ion source. | 06-20-2013 |
20130161506 | DATA ACQUISITION MODES FOR ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY - Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement a combination of drift-type ion mobility (IM) separation and time-of-flight mass spectrometry (TOF MS). Both separation techniques are carried out in tandem while applying mass filtering with a wide window of ion isolation. One mode of operation entails utilizing a mass filter to limit ion packets to ions in a selected m/z range that remains constant over the entire course of data acquisition. Another mode entails utilizing the mass filter to limit ion packets to an m/z range that varies over the course of data acquisition. | 06-27-2013 |
20130161507 | MASS SPECTROMETER AND MASS SPECTROMETRY - A mass spectrometer featured in including an ion source including a first electrode, a second electrode, and a dielectric unit having a sample introducing unit and a sample discharging unit and provided between the first electrode and the second electrode, a power source of ionizing a sample by a discharge generated between the first electrode and the second electrode by applying an alternating current voltage to either one of the first electrode and the second electrode, a mass spectrometry unit of analyzing an ion discharged from the sample discharging unit, and a light irradiating unit of irradiating an area of generating the discharge with light. | 06-27-2013 |
20130161508 | METHOD OF MASS-SPECTROMETRY AND A DEVICE FOR ITS REALIZATION - The present invention relates to the analytical electronics used to identify compositions and structures of substances, in particular, to the analyzers comprising at least one mass-spectrometer (MS) and may be applied in such fields as medicine, biology, gas and oil industry, metallurgy, energy, geochemistry, hydrology, ecology. | 06-27-2013 |
20130161509 | METHOD AND APPARATUS FOR DETECTING AND IDENTIFYING GASES BY MEANS OF ION MOBILITY SPECTROMETRY - The invention relates to a method for identifying gases, which are ionized and the drift times of the positive and negative product ions through drift spaces are measured and the measured drift times are evaluated, wherein for measuring the drift times the product ions are accelerated to drift velocities by a resulting electrical field. It is provided that the positive and negative product ions move synchronously and in parallel in the same direction. | 06-27-2013 |
20130168544 | METHODS FOR DETECTING LACOSAMIDE BY MASS SPECTROMETRY - Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample. | 07-04-2013 |
20130168545 | SPECTROSCOPY DATA DISPLAY SYSTEMS AND METHODS - Spectroscopy data are correlated to physical locations on a sample. A laser beam is scanned along a beam trajectory relative to the sample located in a sample chamber. The laser beam disassociates material from the sample along the beam trajectory to produce an aerosol of the disassociated material within the sample chamber. A fluid is passed through the sample chamber to transport the disassociated material to a spectrometer for determining spectroscopy data values of a selected element along the beam trajectory. The spectroscopy data values are correlated with respective locations of the sample along the beam trajectory, and an image is displayed of at least a portion of the sample including the respective locations along the beam trajectory where the material was disassociated by the laser beam. The image includes indicia of the spectroscopy data values at their correlated locations. | 07-04-2013 |
20130168546 | Method of Mass Spectrometry and Mass Spectrometer Using Peak Deconvolution - A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum. | 07-04-2013 |
20130175439 | Mass Spectrometer - A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. Transient DC voltages are applied to the electrodes in order to urge ions along the length of the mass analyser. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser. | 07-11-2013 |
20130181123 | SATURATION CORRECTION FOR ION SIGNALS IN TIME-OF-FLIGHT MASS SPECTROMETERS - The invention relates to time-of-flight mass spectrometers in which individual time-of-flight spectra are measured by detection systems with limited dynamic measurement range and are summed to sum spectra. The invention proposes a method to increase the dynamic range of measurement of the spectrum. To achieve this, those ions signals whose measured values display saturation of the analog-to-digital converter (ADC) are replaced by correction values, particularly if several successive measured values are in saturation. The correction values are obtained from the width of the signals, preferably simply from the number of measured values in saturation. | 07-18-2013 |
20130181124 | ION TRAP TYPE MASS SPECTROMETER AND MASS SPECTROMETRY - Provide is an ion trap mass spectrometer which is configured to gain an MS spectrum of only fragment data in an MS/MS analysis, thereby makes it possible to perform the analysis in a short period. For this purpose, the device is comprised of: an ionization unit configured to ionize a sample which has been separated into respective components; an ion trap unit configured to trap ions ionized by ionization unit in an electric field and eject the ions in accordance with the respective masses of the ions; a detection unit configured to detect the ions ejected from the ion trap unit; and a processing unit configured to generate an MS spectrum (mass spectrum) on the basis of data detected in the detection unit. The processing unit further configured to gain an MS spectrum of only fragment data of a target ion from a difference between an MS spectrum gained in an MS analysis made before and/or after an MS/MS analysis and an MS spectrum gained in the MS/MS analysis. | 07-18-2013 |
20130181125 | METHOD AND SYSTEM FOR INCREASING THE DYNAMIC RANGE OF ION DETECTORS - A mass spectrometer system can include a mass analyzer operable to mass transmit streams of ions to a detector in a mass dependent fashion for measurement of ion flux intensity. An ion attenuator can be located in the extraction region between the mass analyzer and detector, downstream of the mass analyzer, and can be operable to provide selective attenuation of the ion beam by attenuating ion flux intensity also in mass dependent fashion. Higher concentration ions can be selected and attenuated, while other lower concentration ions can be left unattenuated. Different ions can be attenuated to different degrees. Locating the ion attenuator downstream of the mass analyzer so that the ion beam is already mass differentiated when attenuated can avoid mass discriminatory effects associated with ion beam attenuators. Selective attenuation of only certain ions but not others can extend the dynamic range of the detector without necessarily sacrificing detector sensitivity. | 07-18-2013 |
20130187036 | CHARACTERIZATION OF PETROLEUM SATURATES - A method for characterizing the saturates portion of a petroleum or hydrocarbon sample that includes compounds with boiling points of 1000° F. (538° C.) or higher includes use of laser desorption ionization (LDI) to desorb and vaporize petroleum saturates into the gas phase. After ionization, the saturate compounds cations can be detected using mass spectrometry. The mass spectrum generated from the ionized saturated compounds is then characterized by assigning molecular formulas to any “detected” masses that exhibit a peak with an intensity greater than a defined signal to noise threshold. After making the molecular assignments, the abundance of each assigned molecule can be determined based on the signal magnitude of the peaks in the mass spectrum. The assigned molecules and the corresponding abundances can then be grouped based on a variety of factors. | 07-25-2013 |
20130187037 | PARALLEL ION MASS AND ION MOBILITY ANALYSIS - The present invention relates to a parallel IMS and MS measurement method where a sample flow is split and delivered to an IMS and a MS in parallel. A parallel acquisition MS/IMS method is used to supplement LC-MS and or MS data by using a synchronized MS/IMS acquisition. | 07-25-2013 |
20130187038 | Methods and Systems for Matching Product Ions to Precursor Ions - Methods of tandem mass spectrometry are disclosed, characterized by: providing a mixture of precursor ions comprising a plurality of individually isolated ion types of respective selected m/z ratios; estimating an elemental composition for each precursor ion type based on its respective m/z ratio; generating a sample of fragment ions comprising a plurality of fragment ion types by fragmenting the plurality of precursor ion types of the mixture; generating a mass spectrum of the fragment ion types to determine a respective m/z ratio or m/z ratio range for each respective fragment ion type; estimating an elemental composition for each fragment ion type based on its respective m/z ratio or m/z ratio range; and calculating probabilities, for each precursor ion type, that a fragment ion type or a pair of fragment ion types was derived from said precursor ion type. | 07-25-2013 |
20130187039 | VITAMIN B2 DETECTION BY MASS SPECTROMETRY - Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques. | 07-25-2013 |
20130187040 | IONISATION MASS SPECTROMETRY - Systems that employ microdroplets are used in embodiments for Microdroplet Electrospray Ionisation Mass Spectrometry (ESI MS). Thus, a method of detecting an analyte includes providing an oil composition comprising oil and an aqueous microdroplet comprising the analyte, the oil composition comprising a surfactant to stabilise the aqueous microdroplet in the oil composition; and performing ionisation mass spectrometry analysis of the oil composition. | 07-25-2013 |
20130187041 | CHARGED PARTICLE SPECTRUM ANALYSIS APPARATUS - A charged particle spectrum analysis apparatus comprising an electric field generator arranged to subject charged particles to a time-varying electric field, a detector to record charged particle time spectrum data of charged particles which have passed through the electric field, the detector comprising a position-sensitive detection portion, and the time-varying electric field arranged to be activated in synchrony with activation of detector, and the time-varying electric field arranged to subject a predetermined region of said detection portion to consecutive charged particle deflection cycles. | 07-25-2013 |
20130193318 | ION SOURCE FOR MASS SPECTROMETERS - Ion sources for use in mass spectrometry (MS) systems are described. The ion sources each comprise an ion funnel and an ionization source configured to ionize neutral analyte molecules. | 08-01-2013 |
20130200257 | METHOD AND DEVICE FOR MEASURING GLOW DISCHARGE SPECTROMETRY IN PULSED MODE - The present invention relates to a device for measuring glow discharge spectrometry in pulsed mode, which includes an RF electric field generator in pulsed mode, a discharge lamp, an impedance matching device for transferring the electric power supplied by the generator to the discharge lamp and a mass spectrometer suitable for measuring at least one signal representative of an ionised plasma species. According to the invention, the device includes a measurement system suitable for measuring a signal representative of the impedance mismatch ΔΩ between the generator and the discharge lamp, said measurement system including a fast acquisition system, synchronized with the pulses and suitable for supplying the impedance matching device with a signal representing the impedance mismatch ΔΩ for at least one part of said pulses. The device enables continuous impedance adaptation. | 08-08-2013 |
20130200258 | Method And System Of Identifying A Sample By Analyising A Mass Spectrum By The Use Of A Bayesian Inference Technique - A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured spectrum of data from a sample using a mass spectrometer, deconvoluting the measured spectrum of data by Bayesian inference to produce a family of plausible deconvoluted spectra of data, inferring an underlying spectrum of data from the family of plausible deconvoluted spectra of data and using the underlying spectrum of data to identify and/or characterise the sample. | 08-08-2013 |
20130200259 | IDENTIFICATION OF ANALYTES BY AN ION MOBILITY SPECTROMETER WITH FORMATION OF DIMER ANALYTES - The subject of the invention is a method for identification of analytes with an ion mobility spectrometer by performing a series of measurements while varying the residence time of the analytes in the reaction space and identifying of monomer and nascent dimer analytes in the spectra so obtained. | 08-08-2013 |
20130206973 | MASS SPECTROMETER HAVING AN ION GUIDE WITH AN AXIAL FIELD - A mass spectrometer having an ion guide with an axial field is described. The ion guide includes electrodes with longitudinally extending gaps and inserts configured to be proximate to the gaps. | 08-15-2013 |
20130206974 | Mass Spectrometer Incorporating Hydrogen-Deuterium Exchange - A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange. | 08-15-2013 |
20130206975 | MOLECULAR ION ACCELERATOR - A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte. | 08-15-2013 |
20130206976 | Nanomanipulation Coupled Nanospray Mass Spectrometry (NMS) - A coupled nanomanipulation and nanospray mass spectrometry (NMS) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a NMS. The bio-workstation primarily comprises of a nanomanipulator stage with a plurality of nano-positioners attached to a cabinet with a piezo voltage source and a pressure injector. The present invention further describes a fingerprint lift method that when coupled with the system disclosed herein can be used for retrieval and analysis of trace amounts of drug and explosive residues. The system described herein has been used in the areas of trace and document analysis within the forensic field, trace fiber analysis, and electrostatic lifts for illicit drugs, as well as document and painting analysis. | 08-15-2013 |
20130206977 | METHOD FOR CRYSTALLIZING LOW MASS IONS FOR DIAGNOSING COLORECTAL CANCER AND METHOD FOR DIAGNOSING COLORECTAL CANCER USING SAME - The present invention provides a method for crystallizing low mass ions for diagnosing colorectal cancer by using a MALDI-TOF mass spectrometer to biostatistically analyze low mass ions, which are extracted from a biological sample, and a method for providing information for diagnosing colorectal cancer using same. The present inventions can provide a diagnostic method, which requires low cost and a short time for analysis, can analyze large areas, and which can provide superior and credible discriminations. | 08-15-2013 |
20130206978 | TIME-OF-FLIGHT MASS SPECTROMETER WITH ACCUMULATING ELECTRON IMPACT ION SOURCE - An accumulating ion source for a mass spectrometer that includes a sample injector ( | 08-15-2013 |
20130206979 | Data Independent Acquisition of Product Ion Spectra and Reference Spectra Library Matching - Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored. | 08-15-2013 |
20130206980 | CHARACTERIZATION OF PETROLEUM SATURATES - A method for characterizing the saturates portion of a petroleum or hydrocarbon sample that includes compounds with boiling points of 1000° F. (538° C.) or higher includes use of laser desorption ionization (LDI) to desorb and vaporize petroleum saturates into the gas phase. After ionization, the saturate compounds cations can be detected using mass spectrometry. The mass spectrum generated from the ionized saturated compounds is then characterized by assigning molecular formulas to any “detected” masses that exhibit a peak with an intensity greater than a defined signal to noise threshold. After making the molecular assignments, the abundance of each assigned molecule can be determined based on the signal magnitude of the peaks in the mass spectrum. The assigned molecules and the corresponding abundances can then be grouped based on a variety of factors. | 08-15-2013 |
20130206981 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 08-15-2013 |
20130214147 | Apparatus and Method for Inhibiting Ionization Source Filament Failure - An ion source apparatus for a mass spectrometer comprises a refractory metal filament operable to provide a flow of electrons by thermionic emission; an electrical current source electrically coupled to the filament for heating the filament; a vacuum chamber enclosing the filament; an ionization volume within the vacuum chamber capable of receiving the flow of electrons; a source of an oxygen-providing gas or gases; a restrictive fluidic coupling to the source of oxygen-providing gas or gases; and a gas conduit fluidically coupled to the restrictive fluidic coupling, the restrictive fluidic coupling and conduit operable to provide a flow of the oxygen-providing gas or gases into the vacuum chamber so as to maintain a partial pressure of said gas or gases within the vacuum chamber that is sufficiently high so as to inhibit the otherwise formation of a carbonaceous growth on the filament in the presence of a gaseous carbon-containing material. | 08-22-2013 |
20130214148 | TRIPLE SWITCH TOPOLOGY FOR DELIVERY ULTRAFAST PULSER POLARITY SWITCHING FOR MASS SPECTROMETRY - There is provided a pulser, a time of flight mass spectrometer system comprising the same, and a method of analyzing the ions using the pulser. The pulser comprises a first positive switch for coupling and decoupling a first electrode of the accelerator assembly to a first positive voltage; a first negative switch for coupling and decoupling the first electrode to a first negative voltage; and, a first bipolar switch for alternately coupling and decoupling the first electrode to a third voltage. | 08-22-2013 |
20130214149 | Ion Guiding Device - An ion guiding device is disclosed comprising a first ion guide which is conjoined with a second ion guide. Ions are urged across a radial pseudo-potential barrier which separates the two guiding regions by a DC potential gradient. Ions may be transferred from an ion guide which has a relatively large cross-sectional profile to an ion guide which has a relatively small cross-sectional profile in order to improve the subsequent ion confinement of the ions. | 08-22-2013 |
20130214150 | LASER ABLATION ELECTROSPRAY IONIZATION (LAESI) FOR ATMOSPHERIC PRESSURE, IN VIVO, AND IMAGING MASS SPECTROMETRY - The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI) | 08-22-2013 |
20130214151 | Mass Spectrometric Methods for Quantifying NPY 1-36 and NPY 3-36 - Provided are methods of detecting the presence or amount of NPY 1-36 or NPY 3-36 in a sample using mass spectrometry. Importantly, by methods of the invention, both NPY 1-36 and NPY 3-36 can be quantified simultaneously, separately, and independently in a sample that contains both peptides. The methods provide enhanced specificity, and excellent sensitivity with limits of quantitation (LOQ) of about 0.1 ng/mL, and are accomplished in less time and with less sample preparation than required in other assays for NPY. In certain embodiments, because the methods of the invention are specific for both NPY 1-36 and NPY 3-36, the methods provide a major advantage over existing immunoassays. Therefore, the methods may be used to obtain reliable concentration data in several important patient populations, such as patients with hypertension, heart disease, or cancer. | 08-22-2013 |
20130221216 | METHOD AND APPARATUS FOR IMPROVING THE THROUGHPUT OF A CHARGED PARTICLE ANALYSIS SYSTEM - A method of increasing ion throughput within an accumulator, an energy lift and a pulsed ion extractor, operated in that order upon a batch of ions, comprising the steps of: firstly loading a batch of ions into the accumulator; secondly changing the electrical potential of the energy lift to raise the energy of the batch of ions contained therein; and thirdly ejecting the batch of ions from the pulsed ion extractor; and wherein: the energy lift is a separate device from the accumulator and the pulsed ion extractor, and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator and/or a previous batch of ions is prepared for ejection in the pulsed ion extractor; or the energy lift is incorporated into the pulsed ion extractor and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator; or the energy lift is incorporated into the accumulator and whilst changing the electrical potential in the second step a previous batch of ions is prepared for ejection in the pulsed ion extractor. A charged particle analyzer system is also provided. | 08-29-2013 |
20130228678 | MS/MS Data Processing - A method of identifying precursor ion species from their fragments comprises obtaining mass spectra of a plurality of precursor ion species and their fragments to high mass accuracy. The fragment mass spectrum, obtained from fragmentation of multiple precursor ion species, is then scanned it identify pairs of fragments whose combined mass matches the mass of one of the precursor ion species. Once pairs of fragment ion shave been matched to precursor ions, the composite fragment ion spectrum is broken down into portions, one per fragment pair. Analysis continues until no further pairs are identified. A simplified fragment ion spectrum is then reconstructed for each precursor sample ion by stitching together the broken down sections of the composite fragment spectrum. The resultant reconstructed, simplified fragment spectra are sent to a search engine which returns a score—sorted list of likely candidates for each synthetic fragment ion spectrum. | 09-05-2013 |
20130228679 | Multiple Ion Injection in Mass Spectrometry - This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions. | 09-05-2013 |
20130228680 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 09-05-2013 |
20130228681 | FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER AND METHOD FOR CONCENTRATING IONS FOR FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY - A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell. | 09-05-2013 |
20130228682 | MASS SPECTROMETER AND MASS SPECTROMETRY METHOD - A mass spectrometer is provided including: a collision chamber of generating fragment ions by superimposingly applying an AC voltage and a first DC voltage between linear multipolar electrodes, and accelerating the fragment ions by applying a second DC voltage between a front stage electrode and a later stage electrode; a mass spectrometer unit of carrying out mass separation of the fragment ions; and a control unit of determining the second DC voltage based on the mass-to-charge ratios such that the rates of the fragment ions in the collision chamber become equal regardless of the mass-to-charge ratios. Herein, the control unit increases the second DC voltage as the mass-to-charge ratios selected by the mass spectrometer unit become larger. This allows the mass window to be wider even when a DC electric field is generated in order to solve a crosstalk drawback, in the movement direction of the molecular ions. | 09-05-2013 |
20130234013 | Detection System Assembly, Dryer Cartridge, And Regenerator And Methods For Making And Using The Same - A detection system assembly is provided. The detection system assembly includes a detector system including a housing having a sample port configured to receive a sample of an unknown substance, a detector assembly in flow communication with the sample port, and a pump in flow communication with the detector assembly. The detection system assembly further includes a dryer cartridge removably coupled to an outer surface of the housing of the detector system. The dryer cartridge is in flow communication with the pump and the detector assembly. | 09-12-2013 |
20130234014 | CORRECTED MASS ANALYTE VALUES IN A MASS SPECTRUM - A method for determining a mass-to-charge ratio of an analyte is described that accounts for space charge limitations when there are relatively high concentrations of ions in an ion trap. The method includes calibrating a mass spectrometer for the space charge effects caused by the analyte ion itself and also for adjacent ions that have a mass-to-charge ratio different than the analyte ion. A mass spectrum can be measured for both an analyte ion and an adjacent ion where there is a relatively high concentration of ions in the ion trap. A corrected mass-to-charge ratio can be calculated for an analyte ion based on the measured analyte mass-to-charge ratio, the measured analyte abundance, the first mass-to-charge ratio difference, and the measured first adjacent ion abundance. The resulting corrected mass-to-charge ratio has an increased accuracy and at the same time improves the dynamic range of the ion trap mass analyzer. | 09-12-2013 |
20130234015 | METHOD AND DEVICE FOR CARRYING OUT A QUANTITATIVE SPATIALLY RESOLVED LOCAL ANALYSIS AND DISTRIBUTION ANALYSIS OF CHEMICAL ELEMENTS AND IN SITU CHARACTERIZATION OF ABLATED SURFACE REGIONS - A laser ablation chamber, which is suitable for use in a conventional laser-assisted micro dissection unit (LMD), in combination with the LMD allows for both quantitative spatially resolved nanolocal analysis and distribution analysis of element concentrations of a sample, and a microscopic detection of the surface topography of the same sample, in the nanometer range. Optionally, further examinations may follow, without having to remove the sample from a microscope slide bearing the sample. For the examination, a region of the sample to be analyzed is selected with the aid of a microscope of a LMD. For this purpose, the sample is located on the lower face of a cover slip (microscope slide), which also forms part of a laser ablation chamber mounted beneath the microscope slide and inside the LMD. A portion of the sample is ablated and analyzed. Optionally, the existing LMD instrumentation may be used to deliberately cut out certain regions of the tissue in which metals were detected for further analytics and to collect these regions in sample containers, which are mounted beneath the microscope slide after the laser ablation. | 09-12-2013 |
20130234016 | Mass Spectrometer - A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF. | 09-12-2013 |
20130240722 | PROBABILITY-BASED MASS SPECTROMETRY DATA ACQUISITION - An algorithm-based system and method for tandem mass spectrometry data acquisition in which multiple precursor ion attributes, such as mass, intensity, mass-to-charge ratio and charge state, as well as results from previously performed mass spectrometry scans, are used to determine the likelihood of identification for each precursor ion. This information is then used to prioritize subsequent tandem mass spectrometry events, such as which precursor ions are to be fragmented and undergo further mass spectrometry analysis. By interrogating precursor ions in order of probability of successful identification, an increase in identified proteins and peptides is achieved | 09-19-2013 |
20130240723 | Systems and Methods for Rapidly Screening Samples by Mass Spectrometry - Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans. | 09-19-2013 |
20130248700 | HPLC CAPILLARY COLUMN DEVICE - A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection. | 09-26-2013 |
20130248701 | MASS SPECTROMETRY - There is provided a sampling interface for use with a mass spectrometry apparatus. The sampling interface is arranged so as to enable the sampling of ions in a mass spectrometer. In one aspect, the sampling interface comprises an inlet for receiving a quantity of ions from an ion source, and a region downstream of the inlet for accommodating a gas through which the ions may pass, wherein a field having a selected bias voltage potential is provided in at least a portion of the downstream region through which the ions may pass. | 09-26-2013 |
20130248702 | Method of Mass Separating Ions and Mass Separator - A method of separating ions according to their time of flight is provided comprising: a. providing an analyser comprising two opposing ion mirrors, each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis with the outer field-defining electrode system surrounding the inner field-defining electrode system and creating therebetween an analyser volume; b. injecting ions into the analyser volume or creating ions within the analyser volume so that they separate according to their time of flight as they travel along a main flight path whilst undergoing a plurality of axial oscillations in the direction of the analyser axis and a plurality of radial oscillations whilst orbiting about one or more inner field-defining electrodes; c. the plurality of axial oscillations and plurality of radial oscillations causing the separated ions to intercept an exit port after a predetermined number of orbits. Also provided is an analyser for performing the method, comprising: the two opposing ion mirrors which abut at a first plane, wherein the outer field-defining electrode system of one mirror comprises two sections, the sections abutting at a second plane, comprising a first section between the first plane and the second plane, and a second section adjacent the first section and wherein the first section has at least a portion which extends radially from the analyser axis a greater extent than an adjacent portion of the second section at the second plane. | 09-26-2013 |
20130256523 | GAS CHROMATOGRAPH-MASS SPECTROMETER TRANSFER LINE - A transfer line for conveying the column effluent from a gas chromatograph to an ion source of a mass spectrometer has a transfer line body and a mechanism for moving the transfer line body either towards or away from the mass spectrometer. A gas seal between the housing of the mass spectrometer and the transfer line body prevents vacuum leak when the transfer line body is moved. In one embodiment, the transfer line body outer periphery is threaded and a hand wheel engages the transfer line body threads via complementary threads in order to move the body. When the transfer line is moved towards the mass spectrometer, the body presses an ion source, which is not rigidly fixed to the housing of the mass spectrometer, into a recess seat of the housing, and aligns the ion source in an operating position. | 10-03-2013 |
20130256524 | Mass Spectrometer With Beam Expander - A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser. | 10-03-2013 |
20130256525 | SAMPLE ANALYSIS AND ION DETECTION - Various embodiments of ion detection systems, devices, and associated methods of operation are described herein. In one embodiment, a method for ion detection includes separating a target species from other species in an ionized sample of a first polarity, generating ions of a second polarity opposite the first polarity, and contacting ions of the second polarity with the ionized sample to generate emissions after separating the target species from other species in the ionized sample. The method also includes detecting the generated emissions when combining the ionized sampled of the first polarity with the ions of the second polarity. | 10-03-2013 |
20130264473 | ION DETECTION - Mass analysers and methods of ion detection for a mass analyser are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal. | 10-10-2013 |
20130270432 | TIME-OF-FLIGHT MASS SPECTROMETER - A time-of-flight mass spectrometer includes a holder that holds a sample, an irradiation unit that irradiates a surface of the sample with primary ions, an extractor electrode that opposes the sample, and an ion detector that detects a secondary ion emitted from the surface of the sample in accordance with a time of flight of the secondary ion. The surface of the sample has first and second positions, and the irradiation unit and the holder are disposed so that the primary ions are obliquely incident upon the surface of the sample. A primary ion reaches the first position before another primary ion reaches the second position. A potential gradient generator generates a potential gradient so that a potential difference between the second position and the extractor electrode is larger than a potential difference between the first position and the extractor electrode. | 10-17-2013 |
20130277547 | APPARATUS PREPARING SAMPLES TO BE SUPPLIED TO AN ION MOBILITY SENSOR - There is provided an analysis apparatus including a unit for preparing a sample gas to be supplied to an ion mobility sensor and a control unit equipped with a function of controlling the unit that prepares the gas. The unit for preparing the gas includes a concentration adjusting mechanism that changes the concentration of the target chemical included in the sample gas, and the control unit includes a driver that acquires a measurement result of the ion mobility sensor and a flow control unit that controls the concentration adjusting mechanism in a direction where is improvement in the measurement result. | 10-24-2013 |
20130277548 | Method Of Mass Spectrometry And A Mass Spectrometer - The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas. | 10-24-2013 |
20130277549 | ANALYSIS APPARATUS AND ANALYSIS METHOD - A compound contained in a sample is analyzed more accurately. Provided is an analysis method using TOF-SIMS in which first spectral data is obtained by irradiating the sample with a first primary ion, second spectral data is obtained by irradiating the sample with a second primary ion, and a surface of the sample is etched by an ion and then the surface of the sample is irradiated with the first primary ion or the second primary ion. The first primary ion is more likely to break a molecular structure of a molecule contained in the sample than the second primary ion. | 10-24-2013 |
20130277550 | Mass Spectrometer Sampling Cone With Coating - A sampling cone of a mass spectrometer is disclosed having a metallic boride coating such as titanium diboride. | 10-24-2013 |
20130277551 | METHOD FOR ASSAYING HYDROCARBONS - A method for determining the amount of hydrocarbons in a composition including hydrocarbons and water, includes:
| 10-24-2013 |
20130284911 | Ion Mobility Spectrometer Including Spaced Electrodes For Filtering - An ion mobility spectrometer has an inlet for an analyte substance opening into an ionization region that produces ions of the substance. Parallel grid electrodes extend laterally across the ion flow path and apply an electric field to the ions that is switchable between a relatively low magnitude alternating field that varies in magnitude over multiple periods and an asymmetric alternating field of sufficiently high magnitude to cause differential mobility effects. A collector collects the passed ions, and an indication of the nature of the analyte substance is produced from the collected ions passed during both the low and high field intervals. Also disclosed is the application of a substantially alternating field between the electrodes, which field varies between a low value and a higher value over a time exceeding that of the alternating period. | 10-31-2013 |
20130284912 | QUANTIFICATION OF IMPURITIES FOR RELEASE TESTING OF PEPTIDE PRODUCTS - The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (MS) detection with or without high performance liquid chromatography (HPLC). The method can be used for the investigation of the quality of peptides and proteins, particularly of pharmaceutical peptides and proteins. | 10-31-2013 |
20130284913 | Process for Monitoring Industrial Fluids and Treatment of Same - Industrial fluids can be monitored by employing differential ion mobility spectrometer to sample the industrial fluids. This process may also include controlling an industrial device or an industrial process using the results of the output from the field asymmetric ion mobility spectrometer. The process may also include employing a device to condition the sample prior to introducing the sample into field asymmetric ion mobility spectrometer. | 10-31-2013 |
20130284914 | FAST-SWITCHING DUAL-POLARITY ION MOBILITY SPECTROMETRY - Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer. | 10-31-2013 |
20130284915 | MASS SPECTROMETRY METHOD, MASS SPECTROMETER, AND MASS SPECTROMETRY SYSTEM - A mass spectrometry method of the present invention is a method for conducting mass spectrometry in such a manner that an ion that is produced from a sample is introduced into a mass spectrometer by using DART or DESI, wherein the mass spectrometer has an ion introduction part for introducing the ion thereinto and the ion introduction part is heated at a predetermined timing. | 10-31-2013 |
20130292561 | BIO-CHIP FOR SECONDARY ION MASS SPECTROSCOPY AND METHOD OF FABRICATING THE SAME - There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle. | 11-07-2013 |
20130292562 | ION MOBILITY SPECTROMETER AND METHOD OF OPERATING SAME - An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments with a activation duration of at least one of the electric field activation sources different than that of the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path. | 11-07-2013 |
20130292563 | Tandem Ion Trapping Arrangement - A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment ions are simultaneously scanned from both the first and second ion trap. At any instant in time the quantity of charge present within the second ion trap is limited or restricted so that the second ion trap does not suffer from space charge saturation effects and hence the performance of the second ion trap is not degraded. | 11-07-2013 |
20130292564 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 11-07-2013 |
20130299688 | TECHNIQUES FOR ANALYZING MASS SPECTRA FROM THERMAL DESORPTION RESPONSE - Techniques are described for sample analysis. Thermal desorption of components of the sample occurs at atmospheric pressure at a plurality of times by applying one of a plurality of temperatures included in a temperature gradient at each of the times to a surface of the sample. Desorption of each component occurs at a different temperature thereby allowing differentiation of the components based on one of the times corresponding to the temperature at which desorption occurs for the component. Ions are generated from the thermally desorbed components. Mass spectra generated from the ions are analyzed to determine mass spectral features about the components. Analyzing includes associating one of the ions with a component if the one ion has an ion intensity apex or peak that is detected in the mass spectra and occurs at a time corresponding to a one of the temperatures at which thermal desorption occurs for the component. | 11-14-2013 |
20130299689 | LINEAR ION TRAP FOR RADIAL AMPLITUDE ASSISTED TRANSFER - Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap. | 11-14-2013 |
20130299690 | METHOD FOR ENHANCING THE RESOLVING POWER OF ION MOBILITY SEPARATIONS OVER A LIMITED MOBILITY RANGE - A method for raising the resolving power, specificity, and peak capacity of conventional ion mobility spectrometry is disclosed. Ions are separated in a dynamic electric field comprising an oscillatory field wave and opposing static field, or at least two counter propagating waves with different parameters (amplitude, profile, frequency, or speed). As the functional dependencies of mean drift velocity on the ion mobility in a wave and static field or in unequal waves differ, only single species is equilibrated while others drift in either direction and are mobility-separated. An ion mobility spectrum over a limited range is then acquired by measuring ion drift times through a fixed distance inside the gas-filled enclosure. The resolving power in the vicinity of equilibrium mobility substantially exceeds that for known traveling-wave or drift-tube IMS separations, with spectra over wider ranges obtainable by stitching multiple segments. The approach also enables low-cutoff, high-cutoff, and bandpass ion mobility filters. | 11-14-2013 |
20130299691 | Ion Source With Surface Coating - A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal. | 11-14-2013 |
20130299692 | MASS SPECTROMETRY METHOD, ION PRODUCTION DEVICE, AND MASS SPECTROMETRY SYSTEM - A mass spectrometry method of the present invention is such that a sample is heated to generate a gas and an ion that is produced from the gas is introduced into a mass spectrometer by using DART so that mass spectrometry is conducted. | 11-14-2013 |
20130306853 | ANALYZING TARGET ANALYTES IN A SAMPLE USING MASS SPECTROSCOPY - A method for determining an amount of an analyte in a sample by mass spectrometry can include the steps of (i) ionizing an analyte from the sample and a deuterated analog of the analyte, to produce an analyte ion and a deuterated analog ion, where the deuterated analog undergoes fragmentation and deuterium scattering during mass spectrometry; (ii) measuring an analyte ion signal and a deuterated analog ion signal by mass spectrometry, where the deuterated analog ion signal is measured using a mass transition resulting from fragmentation and deuterium scattering; and (iii) determining an amount of analyte in the sample using the analyte ion signal and the deuterated analog ion signal. Corresponding kits can include instructions for carrying out the method, together with a deuterated analog of the analyte selected to undergo fragmentation and deuterium scattering during mass spectrometry and exhibit a mass transition resulting from fragmentation and deuterium scattering. | 11-21-2013 |
20130306854 | GELC-MS USING STAIN FREE TECHNOLOGY - Disclosed herein is a method of preparing a protein sample for mass spectroscopy. The method includes separating proteins of the sample on an electrophoresis gel; contacting the proteins with a halo-substituted organic compound; exposing the gel to UV light; detecting fluorescence emitted from the electrophoresis gel; excising at least one portion of the electrophoresis gel based upon the detected fluorescence, wherein said at least one portion contains proteins of the protein sample; and subjecting proteins from the at least one portion to mass spectroscopy. Using this method, more proteins can be identified by GeLC-MS than when the electrophoresis gel is treated with a protein stain or subjected to the gel handling steps accompanying such treatment. | 11-21-2013 |
20130306855 | EFFICIENT DETECTION OF ION SPECIES UTILIZING FLUORESCENCE AND OPTICS - The present disclosure relates to mass spectrometers and ion mobility spectrometers and methods for utilizing them and, in particular, to efficient detection of large size ionic species by attaching fluorescent agents to such species and utilizing high intensity light and appropriate optics to define a detection plane. A mechanism to detect fluorescence photons with high efficiency is coupled thereto. In an exemplary embodiment, a mass or ion mobility analyzer is utilized to separate fluorescent ionic species in space or time. The ionic species absorb and re-emit photons as they transverse the detection plane. The photons are directed to a photon detector that generates an electric signal that defines time or position (or position and time of intersection) of ionic species with the detection plane. | 11-21-2013 |
20130306856 | System and Methods for Ionizing Compounds using Matrix-assistance for Mass Spectometry and Ion Mobility Spectometry - An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges. Placing the sample into a region of sub-atmospheric pressure, the region being in fluid communication with the vacuum of the mass spectrometer or ion mobility spectrometer, produces gas-phase ions of the analyte for mass-to-charge or drift-time analysis without use of a laser, high voltage, particle bombardment, or a heated ion transfer region. This matrix and vacuum assisted ionization process can operate from atmosphere or vacuum and produces ions from large (e.g. proteins) and small molecules (e.g. drugs) with charge states similar to those observed in electrospray ionization. | 11-21-2013 |
20130306857 | METHOD AND SYSTEM FOR MASS SPECTROMETRY - A molecular weight is determined from an actually measured mass spectrum of a target substance, and a database search is performed to extract candidates of a chemical structural formula corresponding to the molecular weight (S | 11-21-2013 |
20130313423 | ADVANCED DEBRIS MITIGATION OF EUV LIGHT SOURCE - Systems and methods for debris mitigation in an EUV light source for semiconductor processes are disclosed. Pulsed DC electric fields are applied to the path of EUV light to reject ions from the EUV path. The pulsed DC fields are triggered to coincide with the presence of debris in the EUV optical path. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 11-28-2013 |
20130313424 | Multireflection Time-of-flight Mass Spectrometer - A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed. | 11-28-2013 |
20130313425 | Electrostatic Trap Mass Spectrometer With Improved Ion Injection - A method of mass spectral analysis in an analytical electrostatic trap ( | 11-28-2013 |
20130313426 | SIGNAL EXTRACTION CIRCUITS AND METHODS FOR ION MOBILITY TUBE, AND ION MOBILITY DETECTORS - Embodiments of the present disclosure relate to substance detection technology, and to signal extraction circuits and methods for ion mobility tubes, and ion mobility detectors, which can solve the problem with the conventional technologies that it is difficult to design and manufacture the leadout circuit for the pulsed voltage on the Faraday plates. A signal extraction circuit for an ion mobility tube includes an DC-blocking module configured to remove a DC voltage contained in a voltage extracted, by a signal leadin terminal, from the Faraday plate, and to output, by a signal leadout terminal, a pulsed voltage contained in the voltage extracted from the Faraday plate. An ion mobility detector includes the signal extraction circuit for an ion mobility tube according to the present invention. A signal extraction method for an ion mobility tube includes extracting a voltage on a Faraday plate in the ion mobility tube, removing a DC voltage contained in the voltage extracted from the Faraday plate, and outputting a pulsed voltage contained in the voltage extracted from the Faraday plate. The present invention is used to extract a pulsed voltage from the Faraday plate. | 11-28-2013 |
20130320203 | Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof - A method of analyzing a biological sample, for example serum or other blood-based samples, using a MALDI-TOF mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a MALDI-TOF sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument. In some embodiments at least 100,000 laser shots and even 500,000 shots are directed onto the sample. It has been discovered that this approach, referred to as “deep-MALDI”, leads to a reduction in the noise level in the mass spectra and that a significant amount of additional spectral information can be obtained from the sample. Moreover, peaks visible at lower number of shots become better defined and allow for more reliable comparisons between samples. | 12-05-2013 |
20130320204 | SAMPLE ANALYSIS METHOD AND ANALYZER - Provided is a sample analysis method of irradiating a sample with a primary ion beam to analyze a secondary ion emitted from the sample by mass spectrometry, the sample analysis method including the steps of cooling a sample placed in a chamber; forming an ice layer on a surface of the cooled sample by discharging one of water and an aqueous solution to the chamber; and irradiating the surface of the sample with the primary ion beam with the ice layer being formed thereon, wherein an amount of the water forming the ice | 12-05-2013 |
20130327934 | Parallel Mass Analysis - A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap. | 12-12-2013 |
20130327935 | METHOD AND DEVICE FOR INCREASING THE THROUGHPUT IN TIME-OF-FLIGHT MASS SPECTROMETERS - The invention relates to a method for increasing the throughput in time-of-flight mass spectrometers as well as a device for conducting the method. | 12-12-2013 |
20130327936 | MICROCHIPS WITH INTEGRATED MULTIPLE ELECTROSPRAY IONIZATION EMITTERS AND RELATED METHODS, SYSTEMS AND DEVICES - Microchips which are particularly suitable for use with a mass spectrometer include a microchip body with at least one fluid channel formed into the microchip body and at least two flat monolithic closely spaced integrated ESI (electrospray ionization) emitters defined by shaped projections formed to extend from one side of the microchip body, a respective one being in fluid communication with a fluid channel. Related systems and methods are also described. | 12-12-2013 |
20130334413 | Fast Pushing Time of Flight Mass Spectrometer Combined With Restricted Mass to Charge Ratio Range Delivery - Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T | 12-19-2013 |
20140001352 | METHOD FOR THE DIELECTRIC BARRIER ELECTROSPRAY IONIZATION OF LIQUID SAMPLES AND FOR THE SUBSEQUENT MASS SPECTROMETRIC ANALYSIS OF THE GENERATED SAMPLE IONS | 01-02-2014 |
20140008528 | NANOPHOTONIC PRODUCTION, MODULATION AND SWITCHING OF IONS BY SILICON MICROCOLUMN ARRAYS - The production and use of silicon microcolumn arrays that harvest light from a laser pulse to produce ions are described. The systems of the present invention seem to behave like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of laser light polarization and the angle of incidence. By providing photonic ion sources, this enables enhanced control of ion production on a micro/nano scale and direct integration with miniaturized analytical devices. | 01-09-2014 |
20140008529 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 01-09-2014 |
20140014830 | Space Focus Time of Flight Mass Spectrometer - A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector. | 01-16-2014 |
20140014831 | CORRECTING TIME-OF-FLIGHT DRIFTS IN TIME-OF-FLIGHT MASS SPECTROMETERS - A method of correcting time-of-flight drift in a mass spectrometer by identifying mass spectral peaks of ions in spectra, detecting ions having substantially the same mass across spectra, determining a time-of-flight drift of the detected ions, and correcting the time-of-flight drift of the detected ions by applying a correction factor to each respective time-of-flight. | 01-16-2014 |
20140014832 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 01-16-2014 |
20140027628 | WAVEFORM GENERATION FOR ION TRAP - An ion trap comprises a ring electrode and opposite first and second endcap electrodes situated at opposite ends of the ring electrode. A waveform generator is configured to vary both frequency and amplitude of an AC waveform applied across the first and second endcap electrodes as a function of time, thereby exciting ions with a band of resonant secular frequencies substantially without exciting ions with adjacent secular frequencies. | 01-30-2014 |
20140027629 | METHOD AND ANALYSER FOR ANALYSING IONS HAVING A HIGH MASS-TO-CHARGE RATIO - A method for mass analysing multiply-charged ions is provided as well as a mass analyser suitable for performing the method, the method comprising: introducing multiply-charged ions into an electrostatic mass analyser where ions undergo multiple changes of direction of motion; detecting the ions in the analyser; and determining the mass-to-charge ratio of at least some of the detected ions; wherein the absolute velocity in the analyser of at least some of the ions whose mass-to-charge ratio is determined is not greater than 8,000 m/s and the average path length over the duration of detection of such ions is longer than required for detecting such ions with a mass-to-charge ratio resolving power of 1,000. High resolution mass spectra of high m/z protein complexes, for example in a native state and with low charge, can be achieved. | 01-30-2014 |
20140027630 | SAMPLING OF CONFINED SPACES - In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container. | 01-30-2014 |
20140027631 | Systems and Methods Extending the Laserspray Ionization Mass Spectrometry Concept from Atmospheric Pressure to Vacuum - Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry. | 01-30-2014 |
20140034825 | ADJUSTING ENERGY OF IONS EJECTED FROM ION TRAP - An ion trap includes a trap exit at which an ion energy adjusting device is located. The adjusting device may be configured for focusing a beam of ions ejected from the trap, reducing the energy distribution of the ions, and/or reducing the average kinetic energy of the ions. The adjusting device may include lenses to which RF and/or DC voltages are applied. | 02-06-2014 |
20140034826 | SYSTEM AND METHOD FOR GROUPING PRECURSOR AND FRAGMENT IONS USING SELECTED ION CHROMATOGRAMS - LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group. | 02-06-2014 |
20140042312 | M/Z Targeted Attenuation on Time of Flight Instruments - A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity. | 02-13-2014 |
20140042313 | HIGH SENSITIVITY MASS SPECTROMETRY SYSTEMS - A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte. | 02-13-2014 |
20140042314 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 02-13-2014 |
20140048698 | Time of Flight Mass Spectrometer Utilizing Overlapping Frames - A time of flight (TOF) spectrometer and a method for operating the same is disclosed. The spectrometer includes an event extractor, a streaming processor, and a FIFO buffer. The event extractor generates a ion event record corresponding to each detected ion, the ion event record including an intensity a plurality of aliases for that detected ion. The streaming processor includes a memory array that stores a TOF spectrum and a probability processor that provides a probability for each alias in each received ion event record and updates the TOF spectrum based on the probabilities. A FIFO buffer receives each of the ion event records after the TOF spectrum has been updated and outputs the oldest ion event record to the streaming processor when a new ion event record is processed by the streaming processor. | 02-20-2014 |
20140048699 | METHOD AND SYSTEM FOR SIMULTANEOUSLY FINDING AND MEASURING MULTIPLE ANALYTES FROM COMPLEX SAMPLES - Method and system for detecting multiple analytes from a sample material by desorption ionization, mass analysis, and multivariate statistical analysis. | 02-20-2014 |
20140048700 | Sample Component Trapping, Release, and Separation with Membrane Assemblies Interfaced to Electrospray Mass Spectrometry - A method and apparatus to trap, release and/or separate sample components in solution passing through a channel with or without packing material present by passing ion current through the channel driven by an electric field. A portion of the ion current includes cation and/or anion species generated from second solution flows separated from the sample solution flow path by semipermeable membranes. Cation and/or anion species generated in the second solution flow regions are transferred into the sample solution flow path through ion selective semipermeable membranes. Ion current moving along the sample solution flow path is controlled by varying the composition of the second solutions and/or changing the voltage between membrane sections for a given sample solution composition. The sample composition may also be varied separately or in parallel to enhance trapping, release and/or separation efficiency and range. | 02-20-2014 |
20140048701 | Pre-Scan For Mass to Charge Ratio Range - A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters. | 02-20-2014 |
20140048702 | Ion Guide With Orthogonal Sampling - A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The Ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar. | 02-20-2014 |
20140048703 | METHODS FOR DETECTING VITAMIN C BY MASS SPECTROMETRY - Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample. | 02-20-2014 |
20140048704 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. | 02-20-2014 |
20140048705 | MASS INDEPENDENT KINETIC ENERGY REDUCING INLET SYSTEM FOR VACUUM ENVIRONMENT - A particle inlet system comprises a first chamber having a limiting orifice for an incoming gas stream and a micrometer controlled expansion slit. Lateral components of the momentum of the particles are substantially cancelled due to symmetry of the configuration once the laminar flow converges at the expansion slit. The particles and flow into a second chamber, which is maintained at a lower pressure than the first chamber, and then moves into a third chamber including multipole guides for electromagnetically confining the particle. The vertical momentum of the particles descending through the center of the third chamber is minimized as an upward stream of gases reduces the downward momentum of the particles. The translational kinetic energy of the particles is near-zero irrespective of the mass of the particles at an exit opening of the third chamber, which may be advantageously employed to provide enhanced mass resolution in mass spectrometry. | 02-20-2014 |
20140054454 | Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers - A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector. | 02-27-2014 |
20140061458 | EXCITATION OF IONS IN AN ICR-CELL WITH STRUCTURED TRAPPING ELECTRODES - In an ion cyclotron resonance cell, which is enclosed at its ends by electrode structure elements with DC voltages of alternating polarity, longitudinal electrodes are divided so that the ICR measurement cell between the electrode structure elements consists of at least three sections. An excitation of ion cyclotron motions can be performed by applying additional trapping voltages to longitudinal electrodes located closest to the electrode structure elements and introducing ions into the center set of longitudinal electrodes. The ions are then excited into cyclotron orbits by applying radiofrequency excitation pulses to at least two rows of longitudinal electrodes to produce orbiting ion clouds. Subsequently, the additional trapping voltages are removed and an ion-attracting DC voltage is superimposed on the DC voltages. Ions excited to circular orbits can be detected using detection electrodes in the outer ICR cell sections. | 03-06-2014 |
20140061459 | FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY SYSTEM - An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow. | 03-06-2014 |
20140070085 | Spinning Cell Device for Fast Standardization in Laser Ablation Inductively Coupled Plasma Spectrometry - A spinning cell device is described for fast and convenient standardization and analysis of constituents and isotopes in solid samples by laser ablation inductively coupled plasma (LA-ICP) spectrometry. The method and apparatus for performing he method require the sample under test and a standard to be spun during ablation allowing the quasi-simultaneous ablation of both materials. The aerosols resulting from the ablation of sample and standard are mixed in the ablation cell allowing quantification of the ablated metals by the method of standard addition or isotope dilution. The relative proportion of standard verses sample ablated can be changed by altering the trajectory of the laser beam. The ablated aerosol is swept into an inductively coupled plasma by a carrier gas and analyzed by mass spectrometry. | 03-13-2014 |
20140070086 | METHOD FOR ANALYZING GLYCAN STRUCTURE - In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the CID energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile. | 03-13-2014 |
20140070087 | ION ANALYSIS APPARATUS AND METHOD - The present invention is concerned with an ion analysis apparatus comprising an ion guide having an ion optical axis extending from an ion inlet to an ion outlet, the ion guide being configured to guide ions from the ion inlet to the ion outlet along the ion optical axis, wherein the ion guide comprises at least one extraction region located between the ion inlet and the ion outlet, the at least one extraction region being configured to extract ions moving along the ion optical axis of the ion guide in an extraction direction, the extraction direction being substantially orthogonal to the ion optical axis of the ion guide, wherein the apparatus includes ion radial confinement means that in use confine the ions in the radial direction within the ion guide. | 03-13-2014 |
20140070088 | IONIZATION DEVICE, MASS SPECTROMETER INCLUDING THE IONIZATION DEVICE, AND IMAGE GENERATION SYSTEM INCLUDING THE IONIZATION DEVICE - An ionization device includes a support configured to support a sample, a probe configured to determine a portion of the sample to be ionized, an irradiation unit configured to emit laser light and is disposed to irradiate with the laser light a liquid bridge portion between the sample and the probe, an extract electrode configured to extract ions obtained by ionizing the sample, a liquid supply unit configured to supply a liquid to a region of the sample, and voltage application units configured to generate an electric field between a portion of the probe that is in contact with the liquid bridge portion and the extract electrode. | 03-13-2014 |
20140070089 | IONIZATION DEVICE, MASS SPECTROMETER INCLUDING THE IONIZATION DEVICE, AND IMAGE GENERATION SYSTEM INCLUDING THE IONIZATION DEVICE - An ionization device includes a laser light irradiation unit, a liquid holding unit having an end portion thereof and being configured to hold a liquid on an outer periphery of the end portion, an extract electrode, and a voltage application unit. The device is configured to operate in at least in two operation modes, and the modes include a first operation mode, in which the liquid at the end portion is brought into contact with the surface of the sample and then ionized particles are generated from the end portion, and a second operation mode, in which the liquid at the end portion is disposed at a location separated from the surface of the sample and the particles desorbed from the surface of the sample as a result of being irradiated with the laser light are ionized using the liquid on the end portion. | 03-13-2014 |
20140070090 | DYNAMICALLY HARMONIZED FT-ICR CELL WITH SPECIALLY SHAPED ELECTRODES FOR COMPENSATION OF INHOMOGENEITY OF THE MAGNETIC FIELD - A method and apparatus of compensating a magnetic field inhomogeneity in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell, the extra electrodes being shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field on the cycling ions. | 03-13-2014 |
20140070091 | Collision Cell - A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. | 03-13-2014 |
20140077075 | Multi-Electrode Ion Trap - This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes. | 03-20-2014 |
20140084151 | Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Imaging (MALDI-MSI) - A method of preparing a sample for matrix assisted laser desorption ionisation mass spectrometry imaging analysis by a two-step process. Firstly, a MALDI matrix is dusted on to the sample followed by a spray of a suitable solvent onto the dusted sample. The present method has been successfully applied to the detection and mapping of several analyte classes in latent fingermarks. Using the present two-step method, fingermark enhancement, recovery and analysis from different substrate surfaces is now possible enabling visual and chemical information to be obtained simultaneously via remote testing. | 03-27-2014 |
20140084152 | MATRIX ADDITIVE FOR MASS SPECTROMETRY - The present invention provides a novel compound that makes it possible to improve ionization efficiency of hydrophobic peptide. 5-alkoxy-2- or -3-hydroxybenzoic acid represented by the following formula (I): | 03-27-2014 |
20140084153 | Nanoparticulate Assisted Nanoscale Molecular Imaging by Mass Spectrometery - Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source. | 03-27-2014 |
20140097338 | MASS SPECTROMETER, SYSTEM COMPRISING THE SAME, AND METHODS FOR DETERMINING ISOTOPIC ANATOMY OF COMPOUNDS - A first mass spectrometer includes a first introduction device configured to select between a reference material and a first portion of an analyte and introduce the selected one of the reference material or the first portion of the analyte to an ion source, the first mass spectrometer being configured to provide third molecular analyte ions to a detector at a first mass resolution of about 30,000 or greater. A system includes the first mass spectrometer and a second mass spectrometer. A method for determining the isotopic composition of an analyte in a sample includes converting a first portion of the analyte to first molecular analyte ions, filtering out second molecular analyte ions, filtering out third molecular analyte ions, detecting two or more of the third molecular analyte ions at a mass resolution of about 30,000 or greater to determine the isotopic composition of at least a portion of the analyte. | 04-10-2014 |
20140103204 | Biomarkers for the Diagnosis and Treatment of Pancreatic Cancer - Compositions and methods which indicate an increased risk for pancreatic carcinoma are disclosed. | 04-17-2014 |
20140110576 | Method of Charge Reduction of Electron Transfer Dissociation Product Ions - A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine. | 04-24-2014 |
20140117220 | VOLTAGE SUPPLIES FOR MASS SPECTROMETERS - The invention relates to the voltage supply of mass spectrometers, particularly electrostatic Kingdon ion analyzers, requiring extremely noise-free operating voltages. The invention proposes the use of passive charge storage devices, which operate without any feedback control and display no measureable noise or ripple if they are well shielded, instead of the usual actively operating high-voltage generators. Chemical charge storage devices or capacitors with good insulation can be used for this purpose. These may display slight voltage decreases due to continuous discharge, depending on their quality, but these decreases can be mathematically compensated. | 05-01-2014 |
20140117221 | METHOD AND SYSTEM FOR VACUUM DRIVEN MASS SPECTROMETER INTERFACE WITH ADJUSTABLE RESOLUTION AND SELECTIVITY - A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit. | 05-01-2014 |
20140117222 | DETECTION APPARATUS AND METHODS UTILIZING ION MOBILITY SPECTROMETRY - A method of and system for analyzing ion mobility of a sample. The sample is received by an ionization chamber, which ionizes molecules of the sample. The ionized sample is received from the ionization chamber by a drift tube coupled to the ionization chamber and propelled along a length of the drift tube in a first direction away from the ionization chamber by an electric field gradient of the drift tube. A magnitude of the electric field gradient is in view of an atmospheric pressure measurement. A drift gas is propelled through the drift tube in a second direction opposite the first direction such that different types of ionized molecules travel through the drift tube at different rates. An arrival time of each of the different types of molecules at a detector located at a second end of the drift tube opposite the first end is detected. | 05-01-2014 |
20140117223 | NON-CONTACT TRACE CHEMICAL SCREENING - Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapour molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance. | 05-01-2014 |
20140117224 | Removal of Ions from Survey Scans Using Variable Window Band-Pass Filtering to Improve Intrascan Dynamic Range - Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows. | 05-01-2014 |
20140117225 | METHOD FOR ANALYZING GLYCAN STRUCTURE - In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the CID energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile. | 05-01-2014 |
20140124660 | Mass Spectrometer With Beam Expander - A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser. | 05-08-2014 |
20140131565 | Ion Guiding Device - An ion guiding device is disclosed comprising a first ion guide which is conjoined with a second ion guide. Ions are urged across a radial pseudo-potential barrier which separates the two guiding regions by a DC potential gradient. Ions may be transferred from an ion guide which has a relatively large cross-sectional profile to an ion guide which has a relatively small cross-sectional profile in order to improve the subsequent ion confinement of the ions. | 05-15-2014 |
20140131566 | Mass Spectrometer - A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimised by the second different RF voltage applied to the downstream group of electrodes. | 05-15-2014 |
20140138531 | Use of Neutral Loss Mass to Reconstruct MS-2 Spectra in All Ions Fragmentation - A method is provided for acquiring and interpreting data using a mass spectrometer, said method comprising: (a) generating a multiplexed mass spectrum using the mass spectrometer system, the multiplexed mass spectrum comprising a superposition of a plurality of product-ion mass spectra comprising a plurality of product-ion types having respective product-ion mass-to-charge (m/z) ratios, each product-ion mass spectrum corresponding to fragmentation of a respective precursor-ion type formed by ionization of a chemical compound, each precursor-ion type having a respective precursor-ion mass-to-charge (m/z) ratio and (b) recognizing a set comprising a precursor-ion type and one or more product-ion types corresponding to each of one or more of the product-ion mass spectra by recognizing one or more losses of a respective valid neutral molecule from each said precursor-ion type. | 05-22-2014 |
20140138532 | RF Power Supply for a Mass Spectrometer - The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output. | 05-22-2014 |
20140138533 | ION MASS SELECTOR, ION IRRADIATION DEVICE, SURFACE ANALYSIS DEVICE, AND ION MASS SELECTING METHOD - A time-of-flight mass selector includes a first ion lens for converging ions, a flight tube into which ions which enter from the first ion lens are introduced, the flight tube having equipotential space therein, a second ion lens for converging ions having passed through the flight tube, and a chopper for a gate for pulsing the ions converged by the second ion lens. | 05-22-2014 |
20140138534 | Mass Spectrometer Device and Method Using Scanned Phase Applied Potentials in Ion Guidance - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 05-22-2014 |
20140138535 | Interpreting Multiplexed Tandem Mass Spectra Using Local Spectral Libraries - A method of acquiring and interpreting data using (i) a mass spectrometer system operated according to a set of operating conditions and (ii) a mass spectral library having a plurality of library entries derived from data previously obtained using said mass spectrometer system operated according to said set of operating conditions comprising: (a) generating, using the mass spectrometer system, a multiplexed mass spectrum comprising a superposition of a plurality of product-ion mass spectra comprising a plurality of product-ion types, each product-ion mass spectrum corresponding to fragmentation of a respective precursor-ion type formed by ionization of the plurality of chemical compounds, each precursor-ion type having a respective precursor-ion mass-to-charge (m/z) ratio and each product ion type having a respective product-ion m/z ratio; and (b) decomposing the multiplexed product-ion mass spectrum, using the mass-spectral library, so as to calculate relative abundances of previously-observed product-ion mass spectra within the multiplexed product-ion mass spectrum. | 05-22-2014 |
20140138536 | Mass Spectrometer and Method of Controlling Same - A mass spectrometer and control method which achieves high-speed scanning while maintaining relatively high sensitivity. The mass spectrometer ( | 05-22-2014 |
20140138537 | Methods for Generating Local Mass Spectral Libraries for Interpreting Multiplexed Mass Spectra - A method of acquiring and compiling data obtained on a mass spectrometer system, comprises: (a) generating a multiplexed mass spectrum comprising a superposed plurality of product-ion mass spectra comprising a plurality of product-ion types, each product-ion mass spectrum corresponding to fragmentation of a respective precursor-ion type, each precursor-ion type and each product ion type having a respective mass-to-charge (m/z) ratio; (b) decomposing the multiplexed product-ion mass spectrum so as to recognize relative abundances of previously-observed product-ion mass spectra within the multiplexed product-ion mass spectrum, the decomposing employing a mass-spectral library having a plurality of entries corresponding to respective product ion mass spectra previously-observed on said mass spectrometer system; (c) recognizing an additional contribution to the multiplexed mass spectrum that is neither attributable to random variation nor to any previously-observed product-ion spectrum; and (d) storing at least one new entry in the mass-spectral library relating to the recognized additional contribution. | 05-22-2014 |
20140138538 | RESOLUTION AND MASS RANGE PERFORMANCE IN DISTANCE-OF-FLIGHT MASS SPECTROMETRY WITH A MULTICHANNEL FOCAL-PLANE CAMERA DETECTOR - A distance-of-flight mass spectrometer (DOFMS) includes an ion source, a field-free region, an extraction region in which ions are accelerated, and a spatially-selective detector for spatially selectively detecting ions extracted by the extraction region. A method for operating a distance-of-flight mass spectrometer DOFMS comprises controlling a detection time in such a way as to permit ions with progressively greater mass-to-charge (m/z) ratios to enter the extraction region of the DOFMS at positions which will permit the ions with progressively greater m/z ratios to enter the detector of the DOFMS, generating a component mass spectrum at each selected value of detection time, and then assembling a composite mass spectrum by shifting the distance-of-flight axis of each component mass spectrum by a distance corresponding to the change in detection time. | 05-22-2014 |
20140145073 | Use of cryogenic ion chemistry to add a structural characterization capability to mass spectrometry through linear action spectroscopy - The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion. | 05-29-2014 |
20140145074 | Mass Spectrometer - A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to their mass to charge ratio by pulsing an applied axial electric field ON and OFF. | 05-29-2014 |
20140151543 | ANALYSIS DEVICE AND ANALYSIS METHOD - Provided is a technique of analyzing particles in real time while collecting and condensing the particles continuously. Gas and/or particles as a detection target substance that are attached to an authentication target | 06-05-2014 |
20140151544 | Exponential Scan Mode for Quadrupole Mass Spectrometers to Generate Super-Resolved Mass Spectra - A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as introduced herein, is enabled in a novel fashion by scanning exponentially the RF and DC voltages on a quadrupole mass filter versus time while maintaining the RF and DC in constant proportion to each other. In such a novel mode of operation, ion intensity as a function of time is the convolution of a fixed peak shape response with the underlying (unknown) distribution of discrete mass-to-charge ratios (mass spectrum). As a result, the mass distribution can be reconstructed by deconvolution, producing a mass spectrum with enhanced sensitivity and mass resolving power. | 06-05-2014 |
20140151545 | Sensitive Ion Detection Device and Method for Analysis of Compounds as Vapors in Gases - An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm | 06-05-2014 |
20140151546 | MULTI-CAPILLARY COLUMN AND HIGH-CAPACITY IONIZATION INTERFACE FOR GC-MS - A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging. | 06-05-2014 |
20140151547 | Atmospheric Pressure Ion Source By Interacting High Velocity Spray With A Target - An ion source is disclosed comprising a nebuliser | 06-05-2014 |
20140151548 | MATRIX FOR MALDI MASS SPECTROMETRY AND MALDIMASS SPECTROMETRY METHOD - Provided is a matrix for MALDI mass spectrometry that has a high ability of ionizing low-molecular-weight compounds, and makes it possible to make measurement in a negative ion mode. The matrix is a matrix for mass spectrometry that contains one or more compounds selected from the group consisting of compounds each represented by the following general formula (I), (II) or (III), and their salts thereof. In the formulae (I), (II) and (III), X and Z are each C or N; R | 06-05-2014 |
20140158878 | Mass Spectrometer - A mass spectrometer is disclosed comprising a time of flight mass analyser. The time of flight mass analyser comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes. A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide. | 06-12-2014 |
20140158879 | Method And System Of Identifying A Sample By Analysing A Mass Spectrum By The Use Of A Bayesian Inference Technique - A method and system for the identification and/or characterisation of properties of a sample using mass spectrometry. The method involves producing a measured data set from a sample using a mass spectrometer, deconvoluting the measured data set by Bayesian inference to produce a family of plausible deconvoluted data sets, inferring an underlying deconvoluted data set from the family of plausible deconvoluted data sets and using the underlying deconvoluted data set to identify and/or characterise the sample. | 06-12-2014 |
20140158880 | ION TRAP QUADRUPOLE MASS FILTER - An ion trap mass spectrometer is provided, including: an electron emitter; an ion trap storing ions generated by ionization resulting from an impact with electrons emitted from the electron emitter; a secondary ion filter for blocking out secondary ions generated due to ions selectively released by the ion trap; and a detector detecting ions selectively released from the ion trap, wherein the electron emitter, the ion trap, the secondary ion filter, and the ion detector are arranged on the same axis, so that a pure mass spectrum can be measured by excluding the secondary ions which are causes of background noise signals in the procedure of detection of the ions by the ion trap mass spectrometer. | 06-12-2014 |
20140158881 | COMPOSITIONS, METHODS, AND KITS FOR QUANTIFYING TARGET ANALYTES IN A SAMPLE - A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry. The method also includes quantifying the target analyte in the single sample using the first calibrator signal, the second calibrator signal, and the target analyte signal. | 06-12-2014 |
20140158882 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 06-12-2014 |
20140166874 | Imaging Mass Spectrometer and Method of Controlling Same - An imaging mass spectrometer capable of reducing the dependence of the resolution of a projection image on mass is offered. Also, a method of controlling this spectrometer is offered. The imaging mass spectrometer includes: a plate on which a sample is placed; a lens system through which ions generated by irradiating the sample with laser light pass; an ion optical system for separating the ions according to flight time corresponding to mass-to-charge ratio; a detection system for measuring arrival positions and flight times of the ions passed through the ion optical system and generating an image of the sample when it is ionized; and a voltage control portion for sweeping the voltage applied to an electrode included in the lens system such that the lens effect of the lens system increases with time during a given period synchronized with the laser irradiation. | 06-19-2014 |
20140166875 | SYSTEMS AND METHODS FOR HIGH THROUGHPUT SOLVENT ASSISTED IONIZATION INLET FOR MASS SPECTROMETRY - A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry. | 06-19-2014 |
20140166876 | Charged Particle Analysers and Methods of Separating Charged Particles - A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyser; and separating the charged particles according to their flight time. An analyser for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam. An array of arcuate focusing lenses may be used which are located at substantially the same z coordinate, the arcuate focusing lenses in the array being spaced apart in the arcuate direction and the array extending at least partially around the z axis, thereby constraining the arcuate divergence of the beam a plurality of times as it flies through the analyser. | 06-19-2014 |
20140166877 | Method of Processing Mass Spectral Data - A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time T | 06-19-2014 |
20140175273 | METHOD FOR THE DETECTION OF INCORRECT DEPOSITION ON A MALDI SAMPLE SUPPORT - The invention relates to a method for the detection of incorrect deposition on a MALDI sample support with several separate sample sites, where after the preparation on the sample support, an area located between two sample sites is sampled with a desorption laser, and a signal of an ion detector in a mass spectrometer is acquired in temporal relation to the sampling. The signal is examined for the presence of a signal which indicates incorrect deposition. An advantage of the method is particularly that it can be carried out using a MALDI ion source and a connected mass analyzer, and that it requires little procedural effort. | 06-26-2014 |
20140175274 | Charged Particle Analysers and Methods of Separating Charged Particles - Methods and analysers useful for time of flight mass spectrometry are provided. A method of separating charged particles comprises the steps of:
| 06-26-2014 |
20140175275 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 06-26-2014 |
20140175276 | TANDEM MASS SPECTROMETER AND TANDEM MASS SPECTROMETRY METHOD - The invention relates to a tandem mass spectrometer comprising an ionisation source ( | 06-26-2014 |
20140183350 | Compact Mass Spectrometer - Mass spectrometers and methods for measuring information about samples using mass spectrometry are disclosed. | 07-03-2014 |
20140183351 | ION GENERATION USING MODIFIED WETTED POROUS MATERIALS - The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. | 07-03-2014 |
20140183352 | Parallel Mass Analysis - A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap. | 07-03-2014 |
20140183353 | ANALYSIS DEVICE, ANALYSIS METHOD, AND STORAGE MEDIUM - An analysis device includes a sample substance spectrum acquisition unit that acquires a plurality of sample substance spectra obtained a plurality of times for a sample substance; a storage unit that stores a plurality of reference spectra for a known substance; a first evaluation value calculation unit that calculates a first evaluation value for a combination of a sample substance spectrum and a reference spectrum extracted from the plurality of sample substance spectra and the plurality of reference spectra, the first evaluation value representing a similarity between a peak intensity ratio of the reference spectrum and a peak intensity ratio of a portion of the sample substance spectrum corresponding to a peak in the reference spectrum; and a second evaluation value calculation unit that calculates a second evaluation value representing a similarity between the sample substance and the known substance based on the first evaluation values for the combinations. | 07-03-2014 |
20140191122 | Mass Analyser - A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode. | 07-10-2014 |
20140191123 | Ion Guide Coupled to MALDI Ion Source - A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other. | 07-10-2014 |
20140197308 | Function Switching With Fast Asynchronous Acquisition - A method of analysing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer. The stream of mass spectral data is then post-processed to produce mass spectra corresponding predominantly to the first and second population of ions. | 07-17-2014 |
20140197309 | SYSTEMS AND METHODS OF DETECTING AND DEMONSTRATING HAIR DAMAGE VIA EVALUATION OF PROTEIN FRAGMENTS - Embodiments of a method for demonstrating type and/or source of hair damage comprises extracting protein fragments from a hair sample with an aqueous solution, testing the resulting protein fragments with the MALDI-MS test, and then either comparing the results between a damaged sample and an undamaged sample or comparing the results between a damaged sample and a list of known marker protein fragments to identify the type and/or source of the damage. | 07-17-2014 |
20140203176 | SYSTEMS AND METHODS FOR REAL-TIME SAMPLING AND ANALYSIS OF BIOMOLECULES BENEATH THE SURFACE OF BIOLOGICAL TISSUE - Provided are systems and methods for real-time sampling and analysis of biomolecules beneath the surface of biological/agricultural tissue/sample. A method for determining fatty acid profiles in agricultural products (for example, seeds) comprises using matrix-assisted laser desorption ionization (MALDI) mass spectroscopy or laser ablation electrospray ionization (LAESI) mass spectroscopy. The MALDI or LAESI mass spectroscopy may be used to profile certain fatty acid traits, such as docosahexanoic acid (DHA), in oil seeds. The disclosed method may be used for a high throughput and/or automated screening of agricultural products, such as seeds, for desirable traits or events. | 07-24-2014 |
20140217275 | Mass Analyser and Method of Mass Analysis - An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion. | 08-07-2014 |
20140217276 | Sequential Low/High-Resolution Library Search - Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c) conduct a unit mass library search, based on the calculated unit masses, to obtain at least one candidate species to thereby identify the sample. The systems and methods may further: (d) calculate exact masses for each of a plurality of candidate species; and (e) eliminate candidate species due to ions that are outside a mass error window. The mass error window may be less than 500 ppm. The system and methods presented may be used in, for example, gas chromatrography mass spectrum and/or liquid chromatography mass spectrometry systems. | 08-07-2014 |
20140217277 | METHOD AND KIT FOR DETECTING HEPCIDIN - A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile. | 08-07-2014 |
20140217278 | Ion Guide With Orthogonal Sampling - A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar. | 08-07-2014 |
20140231641 | GENERATION OF MODEL OF COMPOSITION OF PETROLEUM BY HIGH RESOLUTION MASS SPECTROMETRY AND ASSOCIATED ANALYTICS - A method to determine the model-of-composition of a vacuum resid in which the resid is separated into fractions including the DAO fraction which is then separated into chemical classes including saturates, aromatics, sulfides and polars by a combination of soft ionization methods. The results of the ionization analyses are reconciled with other analyses such as bulk analysis, then consolidated to generate the modeol-of composition. | 08-21-2014 |
20140231642 | Mass Spectrometer With Bypass of a Fragmentation Device - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer. | 08-21-2014 |
20140239169 | DETECTION OF MEMBRANE PROTEIN-THERAPEUTIC AGENT COMPLEXES BY MASS SPECTROMETRY - According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the complex is released from the micelle; (d) ionising the complex; (e) resolving the ionised complex using the mass analyser; and (f) detecting the resolved complex using the detector. Also provided is a solution comprising a detergent micelle in which a complex is contained, wherein the complex comprises a membrane protein bound to a therapeutic agent. | 08-28-2014 |
20140239170 | TANDEM MASS SPECTROMETER AND MASS SPECTROMETRIC METHOD - An ion trap is provided between a collision cell and a time-of-flight mass separator. During a time period in which precursor ions derived from the same compound are selected with a quadrupole mass filter, a collision energy is changed from one to another. Various product ions that are produced by dissociation respectively under collision energies of the plurality of stages and precursor ions that are not dissociated are temporarily trapped in the ion trap, and are ejected in a packet form in the state where these ions are mixed, and are introduced into the time-of-flight mass separator 6 to be subjected to a mass spectrometry. Thereby, in a data processing unit, one MS/MS spectrum in which product ions produced in various dissociation modes under various CID conditions appear is created. | 08-28-2014 |
20140239171 | TECHNIQUES FOR AUTOMATED PERFORMANCE MAINTENANCE TESTING AND REPORTING FOR ANALYTICAL INSTRUMENTS - Techniques are described for performing performance maintenance on a mass spectrometer. Pre-maintenance testing is performed that automating execution of a test sequence in response to a first user interface selection. The maintenance activity performed upon completion of said pre-maintenance testing. Post-maintenance testing is preformed upon completion of said maintenance activity. The post-maintenance testing includes automating execution of the test sequence in response to a second user interface selection. A benchmark comparison is performed to determine whether performance of the mass spectrometer has degraded as a result of performing the maintenance activity, wherein said benchmark comparison is performed automatically in response to completing said post-maintenance testing. | 08-28-2014 |
20140239172 | Method and Apparatus for Mass Spectrometry - A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (MR TOF) mass spectrometry. | 08-28-2014 |
20140239173 | MASS SPECTROMETER - In order to solve a problem in a mass spectrometry that a distribution of an emitted ion and a substance distribution on the measurement object surface are different from each other, which is due to a shaded portion of a irregular surface which falls under a shadow of primary beam, a primary ion optical system of the present apparatus includes a deflection unit configured to deflect the primary ion in such a manner that the primary ion intersects a flight space of the secondary ion in the course of flight. | 08-28-2014 |
20140246575 | Segmented Planar Calibration for Correction of Errors in Time of Flight Mass Spectrometers - An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions. The ion detector system generates separate first mass spectral data sets for each detector element and then applies a calibration coefficient to each of the first mass spectral data sets to produce a plurality of second calibrated mass spectral data sets. The plurality of second calibrated mass spectral data sets are then combined to form a composite mass spectral data set. | 09-04-2014 |
20140246576 | Method and Apparatus for Generating Spectral Data - A method of generating spectral data comprising the steps of deriving a temporally separated sample from a temporal separation device and subjecting the temporally separated sample to an analysis involving scanning at least one spectrally significant parameter, wherein the analysis is performed so that at least two scans in succession are in opposite directions | 09-04-2014 |
20140246577 | Method to Perform Beam-Type Collision-Activated Dissociation in the Pre-Existing Ion Injection Pathway of a Mass Spectrometer - Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows MS | 09-04-2014 |
20140246578 | APPARATUS AND METHOD FOR SAMPLING OF CONFINED SPACES - In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container. | 09-04-2014 |
20140246579 | Multiple Channel Detection for Time of Flight Mass Spectrometer - An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons. The output from each photodiode is connected to a separate Time to Digital Converter provided on an ASIC. | 09-04-2014 |
20140252218 | Methods and Apparatus for Decomposing Tandem Mass Spectra Generated by All-Ions Fragmentation - A method for tandem mass spectrometry of a plurality of eluting compounds comprises: (a) performing, during a time period, the steps of: ionizing the plurality of eluting compounds to generate a plurality of precursor ion species; introducing the plurality of precursor ions into a fragmentation cell operated at constant fragmentation energy so as to generate a plurality of product-ion species from at least a portion of the precursor ion species; and generating a mass spectrum of the plurality of product-ion species; and (b) recognizing matches between certain of the product ion species generated during the time period based on correlations between elution profiles of the product ion species. | 09-11-2014 |
20140252219 | METHODS AND SYSTEMS FOR APPLYING END CAP DC BIAS IN ION TRAPS - A mass spectrometer for analyzing a sample utilizing an ion trap comprises an entrance end cap defining an entrance aperture configured to receive the sample entering the ion trap; a ring electrode defining a ring cavity configured to generate, based on a radio frequency (RF) voltage applied to the ring electrode, an electric field configured to trap the sample received through the entrance aperture; an exit end cap defining an exit aperture configured to receive sample ions exiting the ion trap; and an end cap controller configured to generate a bias control voltage for applying a DC bias potential to at least one of the entrance end or the exit end cap, wherein a value of the bias control voltage is based on an operational parameter of the mass spectrometer. | 09-11-2014 |
20140252220 | MASS SPECTRUM NOISE CANCELLATION BY ALTERNATING INVERTED SYNCHRONOUS RF - A mass spectrometer comprising a controller configured to generate an RF signal to be applied to an electrode during the mass scan, wherein the electrode generates, based on the RF signal, an electric field to be applied to sample ions during a mass scan; an ion detector configured to detect sample ions passing through the electric field and generate a corresponding ion detection signal; and a sampling circuit configured to sample the ion detection signal; wherein the controller is configured to adjust a phase of the at least one RF signal relative to a sample timing of the sampling circuit and average successive mass scans to cancel a portion of the RF signal present in the ion detection signal. | 09-11-2014 |
20140252221 | General Mass Spectrometry Assay Using Continuously Eluting Co-Fractionating Reporters of Mass Spectrometry Detection Efficiency - The invention provides general methods for quantifying any conceivable compound including small organic molecules and biological molecules in mass spectrometric measurements. The methods include the use of chemical or biological reporters such as artificial polypeptides containing proteolytic cleavage sites, which provide proteolytic reporter peptides for standardization of mass spectrometric detection efficiency. In addition to mass spectrometry standardization between different samples, the artificial polypeptides also standardize sample preparation amongst different samples undergoing mass spectrometric analysis when using electrophoresis separation prior to mass spectrometric analysis. Methods of the present invention also include methods for designing artificial polypeptides with peak to peak continuous liquid chromatography elution profiles spanning the complete or partial analyte elution profile for organic and biological molecules. Also included are the artificial polypeptides predigested with protease, which is compatible for use in experiments with native PAGE, in-solution proteolytic digestion of polypeptides, and small organic molecules undergoing fractionation separation followed by mass spectrometric evaluation. | 09-11-2014 |
20140252222 | AUTOMATIC GAIN CONTROL WITH DEFOCUSING LENS - A method and apparatus for performing mass spectrometry using an electron source, an ion trap, and a voltage-controlled lens located between the electron source and the ion trap. A controller applies a voltage to the lens. Features of the resulting output spectrum can be analyzed to determine whether to adjust the lens voltage. | 09-11-2014 |
20140252223 | Tandem Ion Trapping Arrangement - A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment, ions are simultaneously scanned from both the first and second ion trap. At any instant in time, the quantity of charge present within the second ion trap is limited or restricted so that the second ion trap does not suffer from space charge saturation effects and hence the performance of the second ion trap is not degraded. | 09-11-2014 |
20140264001 | MINIATURE CHARGED PARTICLE TRAP WITH ELONGATED TRAPPING REGIONFOR MASS SPECTROMETRY - A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. | 09-18-2014 |
20140264002 | ION TRAP MOBILITY SPECTROMETER AND METHOD OF USING THE SAME - An apparatus for detecting constituents in a sample includes a casing and an ionization chamber defined by the casing. The apparatus also includes an ion collector positioned downstream of the ionization chamber. The apparatus further includes a spectral analysis device coupled to the ion collector. The spectral analysis device is configured to generate a detection spectrum representative of ions collected at the ion collector. The detection spectrum includes an analyte peak portion and a peak tailing portion. The apparatus also includes a control system that is configured to generate a first pulse having a first polarity to initiate a discharge of stored ions from the ionization chamber. The control system is also configured to generate a second pulse substantially immediately after the first pulse. The second pulse has a second polarity opposite the first polarity and is configured to reduce the peak tailing portion. | 09-18-2014 |
20140264003 | Method for Cleaning an Atmospheric Pressure Chemical Ionization Source - Build-up of surface contamination within an atmospheric pressure chemical ionization (APCI) source of a mass spectrometer (MS) is reversed by switching the APCI polarity to the opposite setting used for analyte ionization after the analytes have been ionized and measured. A solvent or mixture of solvents is passed through the ion source during the opposite-polarity operation. This cleaning procedure may be repeated after each sample analysis, especially by incorporating the cleaning procedure into an assay method. The cleaning procedure may be employed simultaneously with chromatography column washing steps and enables a mass spectrometer to maintain useful analysis sensitivity without a need for manual ion source cleaning. | 09-18-2014 |
20140264004 | SYSTEMS AND METHODS FOR ANALYZING A SAMPLE USING A MASS SPECTROMETRY PROBE CONFIGURED TO CONTACT THE SAMPLE - The invention generally relates to systems and methods for analyzing a sample using a mass spectrometry probe having a tip that is configured to contact a sample and retain a portion of the sample once the probe has been removed from the sample. | 09-18-2014 |
20140264005 | ORTHOGONAL ACCELERATION TOF WITH ION GUIDE MODE - Mass spectrometry systems include an electronic controller and a time-of-flight mass analyzer in communication with the electronic controller. The time-of-flight mass analyzer includes a pulsing region defining a channel that extends along an axis. The pulsing region includes: a first electrode extending along the axis, the first electrode defining one or more apertures; a second electrode extending along the axis, the first and second electrodes being positioned on opposing sides of the axis in a first direction perpendicular to the axis. The electronic controller is programmed to apply a first set of voltages to the electrodes to constrain a motion of ions propagating along the axis in a radial direction relative to the axis, and apply a second set of voltages to the electrodes to accelerate the ions out of the pulsing region through the one or more apertures. | 09-18-2014 |
20140264006 | Ion Trap with Radial Opening in Ring Electrode - Apparatuses and methods for performing mass analysis are disclosed. One such apparatus may include an ion trap device. The ion trap device may comprise a first end cap having a first aperture and a second end cap having a second aperture, wherein the first aperture and the second aperture may define an ejection axis. The ion trap device may also comprise a ring electrode substantially coaxially aligned between the first and second end caps. The ring electrode may include an opening extending along a radial direction of the ring electrode, wherein the radial direction is substantially perpendicular to the ejection axis. One such method may include ionizing a sample in an ion trap through an opening separating at least part of first and second ring sections of the ion trap and detecting ions ejected though an aperture on an end cap of the ion trap. | 09-18-2014 |
20140264007 | Identifying the Occurrence and Location of Charging in the Ion Path of a Mass Spectrometer - A method is described for identifying the occurrence and location of charging of ion optic devices arranged along the ion path of a mass spectrometer. The method includes repeatedly performing a sequence of introducing a beam of discharge ions to a location on the ion path, and subsequently measuring the intensities of opposite-polarity sample ions delivered to a mass analyzer, with the discharge ions being delivered to a location further downstream in the ion path at each successive sequence. | 09-18-2014 |
20140264008 | Mass Spectrometer - A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. Transient DC voltages are applied to the electrodes in order to urge ions along the length of the mass analyser. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser. | 09-18-2014 |
20140264009 | DIFFERENTIAL MOBILITY SPECTROMETER AND METHODS THEREOF - An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, a first and a second ion inlet that receive sample ions, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions. | 09-18-2014 |
20140284466 | Method and Apparatus for Pyrolysis-induced Cleavage in Peptides and Proteins - A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5 to 30 seconds. The samples are cleaved at the C-terminus of aspartic acid. The apparatus employs a probe on which the sample is heated and digested components analyzed. | 09-25-2014 |
20140284467 | METHODS OF MONITORING FOR ADHERENCE TO ARIPIPRAZOLE THERAPY - Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed. | 09-25-2014 |
20140284468 | Cancer patient selection for administration of therapeutic agents using mass spectral analysis of blood-based samples - Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a solid epithelial tumor cancer patient is likely to benefit from a therapeutic agent or a combination of therapeutic agents targeting agonists of the receptors, receptors or proteins involved in MAPK (mitogen-activated protein kinase) pathways or the PKC (protein kinase C) pathway upstream from or at Akt or ERK/JNK/p38 or PKC, such as therapeutic agents targeting EGFR and/or HER2. The methods also provide the ability to determine whether the cancer patient is likely to benefit from the combination of a therapeutic agent targeting EFGR and a therapeutic agent targeting COX2; or whether the cancer patient is likely to benefit from the treatment with an NF-κB inhibitor. | 09-25-2014 |
20140284469 | Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection - A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated. | 09-25-2014 |
20140284470 | LENS FOR ELECTRON CAPTURE DISSOCIATION, FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER COMPRISING THE SAME AND METHOD FOR IMPROVING SIGNAL OF FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER - A lens for electron capture dissociation may include: a first electrode and a second electrode spaced apart from each other and arranged along a first direction; and a third electrode and a fourth electrode spaced apart from each other and arranged along a second direction perpendicular to the first direction. The first electrode and the second electrode may be disposed in a space in which a magnetic field is formed in the first direction and trap electrons. The third electrode and the fourth electrode may be in the form of a flat plate and may apply an electric field to the trapped electrons in the second direction. | 09-25-2014 |
20140284471 | Mass Spectrometers Comprising Accelerator Devices - A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device. The potential at which a first length of the flight region is maintained is then changed from a first potential to a second potential whilst at least some ions are travelling within the first length of flight region. The changed potential provides a first potential difference at an exit of the length of flight region, through which the ions are accelerated as they leave the length of flight region. This increases the kinetic energy of the ions prior to them reaching the detector or fragmentation cell. | 09-25-2014 |
20140284472 | Ion Mobility Spectrometer - A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local RF field barrier opposed to a switching DC field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the IMS. The invention is particularly suited for rapid dual gas chromatography. In one important embodiment, the accelerated IMS is coupled to a multi-reflecting time-of-flight mass spectrometer with a fast encoded orthogonal acceleration. There are described methods of comprehensive and orthogonal separation in multiple analytical dimensions. | 09-25-2014 |
20140291501 | Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer - A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser. | 10-02-2014 |
20140291502 | METHODS FOR DETECTING VITAMIN C BY MASS SPECTROMETRY - Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample. | 10-02-2014 |
20140291503 | MASS ANALYSER, MASS SPECTROMETER AND ASSOCIATED METHODS - A mass analyser for use in a mass spectrometer. The mass analyser has a set of electrodes including electrodes arranged to form at least one electrostatic sector, the set of electrodes being spatially arranged to be capable of providing an electrostatic field in a reference plane suitable for guiding ions along a closed orbit in the reference plane, wherein the set of electrodes extend along a drift path that is locally orthogonal to the reference plane and that curves around a reference axis so that, in use, the set of electrodes provide a 3D electrostatic field region. The mass analyser is configured so that, in use, the 3D electrostatic field region provided by the set of electrodes guides ions having different initial coordinates and velocities along a single predetermined 3D reference trajectory that curves around the reference axis. | 10-02-2014 |
20140291504 | Adaptive and Targeted Control of Ion Populations to Improve the Effective Dynamic Range of Mass Analyser - A method of mass spectrometry is disclosed wherein one or more relatively abundant or intense species of ions in a first population of ions are selectively attenuated so as to form a second population of ions. The total ion current of the second population of ions is then adjusted so that the ion current corresponding to ions which are onwardly transmitted to a mass analyser comprising an ion detector is within the dynamic range of the ion detector. | 10-02-2014 |
20140291505 | QUANTIFICATION OF AN ANALYTE IN SERUM AND OTHER BIOLOGICAL MATRICES - Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow. | 10-02-2014 |
20140291506 | NONRADIOACTIVE IONIZATION SOURCE DRIVER - System and method for operating an ionizer using a combination of amplitude modulation and pulse width modulation to control the plasma temperature and the type of ions needed for analytic equipment. Ion density can be controlled by the repetition rate. The ionizer may utilize a non-radioactive ionization source, and be coupled to a differential mobility spectroscopy (DMS) analyzer. | 10-02-2014 |
20140291507 | Multi Inlet For Solvent Assisted Inlet Ionisation - A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionisation (“SAII”) interface. | 10-02-2014 |
20140299760 | MASS DEPENDENT AUTOMATIC GAIN CONTROL FOR MASS SPECTROMETER - Systems and methods for automatic gain control in mass spectrometers are disclosed. An exemplary system may include a mass spectrometer, comprising a lens configured to receive a supply of ions, and a mass analyzer. The mass analyzer may include an ion trap for trapping the supplied ions. The mass analyzer may also include an ion detector for detecting ions that exit the ion trap. The lens may focus the ions non-uniformly based on mass of the ions to compensate for space charge effects reflected in a measurement output of the mass spectrometer. An exemplary method may include focusing an ion beam into a mass analyzer. The method may also include obtaining a mass spectrum and identifying a space charge characteristic based on the mass spectrum. The method may further include defocusing the lens based on the identified space charge characteristic, wherein defocusing the lens is configured to divert lighter ions away from the entrance aperture. The method may include obtaining a mass spectrum of a defocused ion beam generated from the sample. | 10-09-2014 |
20140306103 | Ion Inlet For A Mass Spectrometer - An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets. | 10-16-2014 |
20140306104 | HIGH-THROUGHPUT MASS-SPECTROMETRIC CHARACTERIZATION OF SAMPLES - The invention relates to the characterization of samples which are located in their many hundreds up to tens or hundreds of thousands on a sample support plate in a regular pattern, a so-called array, by ionization with matrix-assisted laser desorption and mass spectrometric measurement, for example. The invention proposes that the position of the sample pattern, and thus the position of each sample in the measuring instrument, for example a mass spectrometer, should be determined by measuring at least two finely structured internal position recognition patterns, such as fine crosses. The position recognition patterns are preferably applied as the samples are generated, with the same apparatus which also generates the sample pattern. A mass spectrometer in which laser spots with diameters of only four to five micrometers can be generated, which can preferably be positioned with an accuracy of one micrometer or better, is particularly suitable for the characterization. | 10-16-2014 |
20140306105 | LIQUID CHROMATROGRAPHY SYSTEMS AND METHODS - One aspect of the invention provides a liquid chromatography system including: a first solvent manager configured to dispense various ratios of a first solvent and a second solvent; a first column in fluid communication with the first solvent manager; a mixer in fluid communication with the first column; a first valve in fluid communication with the mixer; a second column having a first end in fluid communication with a first port of the first valve and a second end in fluid communication with a second port of the first valve; a second solvent manager adapted and configured to dispense various ratios of a third solvent and a fourth solvent; and a second valve in fluid communication with the second solvent manager, the first valve, and the mixer. The first valve and the second valve are adapted and configured for actuation between and a second position. In the first position: solvent dispensed by the first solvent manager and an injected sample flow over the first column; eluent from the first column is mixed with solvent dispensed by the second solvent manager in the mixer to produce a combined mobile phase; and the combined mobile phase is passed through the first valve and over the second column in a first direction to trap analytes of interest on the first column. In the second position, solvent dispensed by the second solvent manager is passed over the second column in a second direction to release the analytes of interest from the second column. | 10-16-2014 |
20140306106 | Method for Automated Checking and Adjustment of Mass Spectrometer Calibration - A method for automatically checking and adjusting a calibration of a mass spectrometer having a first quadrupole (Q1), a fragmentation cell and a mass analyzer comprises: introducing a sample having at least one known chemical entity; decreasing a kinetic energy so as to prevent fragmentation of ions in the fragmentation cell; optionally applying a drag field to the fragmentation cell; ionizing the at least one known chemical entity sample to generate a set of ions; performing a mass scan of the set of ions using Q1; transmitting the scanned ions through Q1 to and through the fragmentation cell; detecting the scanned and transmitted ions by a detector of the mass analyzer; and comparing the results with expected results. Embodiments may include automatic recalibration or notification of possible errors, need for further data processing or an analysis of system performance. | 10-16-2014 |
20140312216 | SIGNAL PROCESSING FOR MASS DIRECTED FRACTION COLLECTION - A system and removing noise from a mass spectrometer signal for fraction collection is described herein. | 10-23-2014 |
20140312217 | METHOD AND APPARATUS FOR LEAK TESTING CONTAINERS - Close containers which are filled with a consumer product are tested on leakiness by means of mass spectrometry ( | 10-23-2014 |
20140312218 | COVALENTLY FUNCTIONALIZED NANODIAMOND-BASED MALDI MATRICES AND METHODS OF USE THEREOF - The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond. | 10-23-2014 |
20140312219 | SIMULTANEOUS INORGANIC MASS SPECTROMETER AND METHOD OF INORGANIC MASS SPECTROMETRY - An inorganic mass spectrometer capable of measuring a relevant and large or the full mass spectral range simultaneously may include a suitable ion source (e.g., an ICP mass spectrometer with an ICP ion source), an ion transfer region, ion optics to separate ions out of a plasma beam, a Mattauch-Herzog type mass spectrometer with a set of charged particle beam optics to condition the ion beam before an entrance slit, and a solid state multi-channel detector substantially separated from ground potential and separated from the potential of the magnet. | 10-23-2014 |
20140312220 | METHOD FOR MASS ANALYSIS - A method and system for analyzing a sample for an iterative information dependent acquisition cycle is disclosed, the method comprising performing an initial survey mass spectrum to generate a spectral peak list from the initial survey mass spectrum, applying threshold criteria to the spectral peak list to generate a threshold spectral peak list, performing a dependent MS/MS on the threshold peak list to obtain a plurality of mass spectra, and based on the plurality of mass spectra, determining exclusion criteria for a plurality of subsequent surveys. For each subsequent scan, the exclusion criteria are applied to generate a precursor list. The subsequent mass spectra for precursors that are common to previous IDA cycles are summed with spectra for the plurality of mass spectra from previous IDA cycles to obtain summed mass spectra. | 10-23-2014 |
20140312221 | Electrostatic Ion Mirrors - An electrostatic ion mirror is disclosed providing fifth order time-per-energy focusing. The improved ion mirror has up to 18% energy acceptance at resolving power above 100,000. Multiple sets of ion mirror parameters (shape, length, and voltage of electrodes) are disclosed. Highly isochronous fields are formed with improved (above 10%) potential penetration from at least three electrodes into a region of ion turning. Cross-term spatial-energy time-of-flight aberrations of such mirrors are further improved by elongation of electrode with attracting potential or by adding a second electrode with an attracting potential. | 10-23-2014 |
20140319331 | NEW USE FOR A COMPOUND AS A MATRIX IN THE SPECIFIC DETECTION, IDENTIFICATION AND/OR QUANTIFICATION OF ALKALOIDS BY MALDI-TOF MASS SPECTROMETRY - There is provided (i) a method of analysing small molecules that may have a mass of <800 Da, in particular alkaloids, said method being generally referred to as MALDI-TOF-MS (or MALDI time-of-flight mass spectrometry), which is an acronym for a method of analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Also provided is (ii) a molecule according to formula (I) and the use of the molecule as a matrix in the analysis method. | 10-30-2014 |
20140319332 | ION MOBILITY SPECTROMETER WITH DEVICE FOR GENERATING AMMONIA GAS - The present invention relates to ion mobility spectrometry, in particular to methods and devices for generating and delivering of ammonia gas as dopant into the ionization region of an ion mobility spectrometer. It provides an ion mobility spectrometer (IMS) with an ion source and device for generating ammonia gas, wherein the device comprises a dopant reservoir filled with alkali metal nitride or alkaline earth metal nitride, preferably lithium nitride and/or magnesium nitride, said reservoir being fluidly coupled to the ion source and to a water reservoir. | 10-30-2014 |
20140319333 | APPARATUS AND METHOD RELATING TO AN IMPROVED MASS SPECTROMETER - A mass spectrometer comprising means for producing a primary beam of ions for bombarding a sample under vacuum, and a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes water clusters where each water cluster contains between 1 and 10,000 water molecules. | 10-30-2014 |
20140319334 | SCREENING FOR PHTHALATES IN FOOD SAMPLES - A method includes the steps of dipping a capillary (e.g., a disposable glass capillary) into a food matrix to deposit a food sample on the capillary; attaching the capillary onto an Atmospheric Solids Analysis Probe (ASAP); loading the ASAP into an atmospheric pressure ionization (API) source enclosure; ionizing the food sample on the capillary within the API source enclosure; and analyzing the ionized sample for the presence of one or more phthalates. | 10-30-2014 |
20140319335 | Low Cross-Talk Fast Sample Delivery System Based Upon Acoustic Droplet Ejection - An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid. | 10-30-2014 |
20140319336 | Intelligent Background Data Acquisition and Subtraction - A scan of a separating sample mixture is received from a mass spectrometer at each interval of a plurality of intervals. It is determined at a first interval that a received mass spectrometry scan at the first interval and one or more preceding received mass spectrometry scans include a varying ion signal that represents an ion of a known compound and has an intensity above a threshold level. The mass spectrometer is instructed to perform a dependent scan for the ion at the first interval producing a spectrum for the known compound. A second interval is selected after the first interval where the varying ion signal has an intensity that is not above the threshold level. The mass spectrometer is instructed to perform a dependent scan for the ion at the second interval producing a spectrum for a background. | 10-30-2014 |
20140326865 | Diathermy Knife Ionisation Source - A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife. An electric current is applied to the diathermy knife such that the diathermy knife vaporises a portion of the substrate. The vapour is aspirated via a sampling tube pumped by a venturi pump into a vacuum chamber of a mass spectrometer. Analyte molecules are aspirated into the vacuum chamber whereupon they impact a surface of the vacuum chamber and are ionised to form analyte ions which are then mass analysed. | 11-06-2014 |
20140326866 | METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY - A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer. | 11-06-2014 |
20140326867 | Mass Spectrometer - A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. | 11-06-2014 |
20140326868 | Nanomanipulation Coupled Nanospray Mass Spectrometry (NMS) - A coupled nanomanipulation and nanospray mass spectrometry (NMS) system for single cell, single organelle, and ultra-trace molecular analysis is disclosed herein. The system primarily comprises a bio-workstation coupled to a NMS. The bio-workstation primarily comprises of a nanomanipulator stage with a plurality of nano-positioners attached to a cabinet with a piezo voltage source and a pressure injector. The present invention further describes a fingerprint lift method that when coupled with the system disclosed herein can be used for retrieval and analysis of trace amounts of drug and explosive residues. The system described herein has been used in the areas of trace and document analysis within the forensic field, trace fiber analysis, and electrostatic lifts for illicit drugs, as well as document and painting analysis. | 11-06-2014 |
20140326869 | METHOD AND APPARATUS FOR DETERMINING A MOBILITY OF IONS - A method and an apparatus for determining a mobility of ions. The method includes the steps of modulating an ion beam with an ion gate which is controlled by a modulation function for generating a modulated ion beam, of guiding the modulated ion beam through a drifting region, of measuring a signal of the modulated ion beam after the modulated ion beam has passed the drifting region and of calculating a correlation of the modulation function and the signal in order to determine the mobility of the ions. The apparatus includes the ion gate, the drifting region through which the modulated ion beam is guidable, a detector by which the signal of the modulated ion beam is measurable after the modulated ion beam has passed the drifting region and a calculation unit by which the correlation of the modulation function and the signal is calculable in order to determine the mobility of the ions. An autocorrelation of the modulation function is a two-valued function. | 11-06-2014 |
20140332679 | Apparatus and Method Relating to an Improved Mass Spectrometer - The present disclosure provides a mass spectrometer including means for producing a primary beam of ions for bombarding a sample under vacuum and a detector for detecting a secondary beam of ions released from the sample. The primary beam of ions includes a gaseous mixture of a cluster forming gas and one or more hydrogen-rich hydrocarbons. | 11-13-2014 |
20140332680 | ION TRAP - An ion trap comprising: a first array of magnetic elements arranged to generate a first magnetic field with a degree of homogeneity; and an array of electrodes arranged to generate an electrostatic field including a turning point in electrical potential at a location where the magnetic field has a substantially maximum degree of homogeneity; wherein the array of electrodes is planar and parallel to the direction of the magnetic field at the location; and wherein a primary first magnetic element is arranged to generate a first component of the first magnetic field and other first magnetic elements are arranged to generate compensating components of the first magnetic field that reduce the gradient, the curvature and higher order derivatives of the first component of the first magnetic field at the location where the first magnetic field has the substantially maximum degree of homogeneity. | 11-13-2014 |
20140332681 | Use of Windowed Mass Spectrometry Data for Retention Time Determination or Confirmation - A scan of a separating sample is received by a mass spectrometer at each interval of a plurality of intervals. The spectrometer performs at each interval one or more mass spectrometry scans. The scans have one or more sequential mass window widths in order to span an entire mass range at each interval and produce a collection of spectra for the entire mass range for the plurality of intervals. One or more peaks at one or more different intervals in the collection of spectra are identified for a fragment ion. A mass spectrum of the entire mass range is retrieved for each interval of each peak. Values for one or more ion characteristics of a mass-to-charge ratio peak in the mass spectrum corresponding to each peak are compared to one or more known values for the fragment ion. Each peak is scored based on the comparison. | 11-13-2014 |
20140332682 | METHODS OF DETECTING REVERSE TRIIODOTHYRONINE BY MASS SPECTROMETRY - Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample. | 11-13-2014 |
20140339416 | METHOD AND APPARATUS TO IMPROVE THE SEPARATION CAPACITY IN A SEQUENCE OF ION FILTERS INCORPORATING AT LEAST TWO ION MOBILITY ANALYZERS - A method and an apparatus are described to improve the separation capacity of an ion analyzer incorporating at least two stages of ion mobility analysis. The new invention utilizes possible use of different mixtures of gases and dopants in each stage, control over different concentrations of gases and dopants in each stage, and allowance of passage of the selected ions from one stage to the next while avoiding the mixing of the gases and dopants among stages. The new invention also includes a method to reduce the time required to identify the physical properties in a set of ion filters where at least one of the filters is a scannable ion mobility analyzer. The present invention also includes how to provide a set of scannable ion mobility analyzers operating in series, wherein each stage can be operated as a filter, or allowing for the passage of all ions. | 11-20-2014 |
20140339417 | SYSTEMS, DEVICES, AND METHODS FOR SAMPLE ANALYSIS USING MASS SPECTROMETRY - A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer. A processing system compares results of the pre-mass spectrometry screening to an analyte database, wherein correlation of the results to an analyte within the analyte database comprises a preliminary positive identification. When the processing system determines that a preliminary positive identification is made, it causes the gate to open for a period of time. However, when the processing system determines that a preliminary positive identification is not made, it causes the gate to remain closed. | 11-20-2014 |
20140339418 | Mass Spectrometer Vacuum Interface Method and Apparatus - A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture. Within the skimmer apparatus, a portion of the skimmed plasma adjacent the skimmer apparatus is separated from the remainder of the skimmed plasma by providing means to prevent, inhibit or impede, the separated portion from reaching the extraction optics while allowing the remainder to expand towards the extraction optics. This allows removal of ions liberated from deposition matter on the skimmer apparatus surface, thereby discriminating against such ions, and offering reduced memory effects. The remainder of the plasma can expand towards the extraction optics, so interaction and mixing between the boundary layer and the remainder of the plasma can be reduced or minimized. | 11-20-2014 |
20140339419 | HIGH RESOLUTION TIME-OF-FLIGHT MASS SPECTROMETER - Mass spectrometers and related methods of making and using the same are disclosed herein that generally involve positioning a blocking or masking element in the path of an ion beam passing through the mass spectrometer so as to selectively block at least a portion of the ions in the ion beam from entering an accelerator. Mass spectrometers and related methods are also disclosed in which an ion beam passing through the mass spectrometer is deflected or otherwise aimed so as to approach a TOF axis of an accelerator at a non-zero angle. | 11-20-2014 |
20140339420 | ATMOSPHERIC PRESSURE ION SOURCE BY INTERACTING HIGH VELOCITY SPRAY WITH A TARGET - An ion source is disclosed comprising a nebuliser and a target. The nebuliser is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionise analyte to form a plurality of analyte ions. | 11-20-2014 |
20140346339 | MULTI-DIMENTIONAL ION MOBILITY SEPARATOR METHOD AND APPARATUS - One aspect of the present invention is to extract multiple ionic species in a FAIMS into one or more IMS drift tubes simultaneously. By adjusting FAIMS operational parameters, ions in FAIMS are detected on IMS detectors through separation in FAIMS and/or separation and collection in the IMS. This method provides a continuous separation of specific ions from an ion swarm by employing a high-field differential mobility analyzer (FAIMS) with a plurality of orthogonal transitions paths spaced incrementally along the electrodes which allow additional separation by a conventional IMS drift tube. The components of the sample can be collected or detected. | 11-27-2014 |
20140346340 | METHOD AND A MASS SPECTROMETER AND USES THEREOF FOR DETECTING IONS OR SUBSEQUENTLY-IONISED NEUTRAL PARTICLES FROM SAMPLES - A method is used in a time-of-flight mass spectrometer for analysis of a first pulsed ion beam, the ions of which are disposed along the pulse direction, separated with respect to their ion masses. The ions of at least one individual predetermined ion mass or of at least one predetermined range of ion masses can be decoupled from the first pulsed ion beam, as at least one decoupled ion beam, and the first ion beam and the at least one decoupled ion beam are analyzed. | 11-27-2014 |
20140346341 | Encoding of Precursor Ion Beam to Aid Product Ion Assignment - A method of encoding a parent or precursor ion beam to aid product ion assignment is disclosed. According to an embodiment the energy of parent ions entering a collision cell is progressively increased. Different species of parent ions fragment at different collision energies. Fragment ion intensity profiles are matched with parent ion intensity profiles to correlate fragment ions with corresponding parent ions. | 11-27-2014 |
20140346342 | Mass Spectrometer With Beam Expander - A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser. | 11-27-2014 |
20140346343 | Collision Cell - A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. | 11-27-2014 |
20140353484 | STRATEGIC DYNAMIC RANGE CONTROL FOR TIME-OF-FLIGHT MASS SPECTROMETRY - A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters. The analog-to-digital converters are configured to provide an increased dynamic range for a targeted period while limiting the amount of data generated. | 12-04-2014 |
20140353485 | MEASUREMENT PLATE FOR MALDI MASS SPECTROMETRY - A measurement plate | 12-04-2014 |
20140353486 | METHODS FOR DETERMINING TOTAL BODY SKELETAL MUSCLE MASS - The present invention is based on the finding that enrichment of D3-creatinine in a urine sample following oral administration of a single defined dose of D3-creatine can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and D3-creatinine in a single sample. The methods of the invention find use, inter alia, in diagnosing disorders related to skeletal muscle mass, and in screening potential therapeutic agents to determine their effects on muscle mass. | 12-04-2014 |
20140353487 | Ion Mobility Separation Device - An ion mobility separator | 12-04-2014 |
20140353488 | SYSTEM AND METHOD FOR RAPID EVAPORATIVE IONIZATION OF LIQUID PHASE SAMPLES - According to some embodiments, systems and methods for rapid evaporation of liquid phase samples are provided. The method includes directing liquid samples to a thermal evaporation ionizing device, thermally evaporating the liquid samples to create gaseous molecular ions, and directing the gaseous molecular ions to an ion analyzer to analyze and provide information regarding the chemical composition of the liquid samples. | 12-04-2014 |
20140353489 | COLLISION ION GENERATOR AND SEPARATOR - According to some embodiments, systems and methods for surface impact ionization of liquid phase and aerosol samples are provided. The method includes accelerating a liquid or aerosol sample, colliding the sample with a solid collision surface thereby disintegrating the sample into both molecular ionic species (e.g., gaseous molecular ions) and molecular neutral species (e.g., gaseous sample), and transporting the disintegrated sample to an ion analyzer. Some embodiments of the method further comprise discarding the molecular neutral species. Such embodiments transport substantially only the molecular ionic species to the ion analyzer. | 12-04-2014 |
20140353490 | MASS SPECTROMETRY SYSTEMS AND METHODS FOR IMPROVED MULTIPLE REACTION MONITORING - The present teachings are directed to methods and apparatuses for mass spectrometry that include configuring mass spectrometry apparatus to perform a plurality of separate assays on ions fragmented from a given analyte, where each such analysis by the spectrometry apparatus is targeted at a different respective associated mass-to-charge ratio and provides a quantitative measure of the number of fragments thereof. | 12-04-2014 |
20140353491 | CREATING AN ION-ION REACTION REGION WITHIN A LOW-PRESSURE LINEAR ION TRAP - Methods and systems for creating a region for ion-ion reactions within a mass spectrometer are described. In various aspects, the methods and systems can confine a first group of ions in a sub-volume of a multipole ion trap, and introduce a second group of oppositely-charged ions into the multipole ion trap while maintaining the first group of ions within the sub-volume. In various embodiments, the methods and systems can operated at reduced pressures. | 12-04-2014 |
20140353492 | MASS SPECTROMETRIC DETERMINATION OF EICOSAPENTAENOIC ACID AND DOCOSAHEXAENOIC ACID - The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods. | 12-04-2014 |
20140361156 | Methods for Simultaneous Quantification of Thyroid Hormones and Metabolites Thereof by Mass Spectrometry - The invention provides methods for simultaneously detecting or simultaneously quantifying any combination of thyroxine (T | 12-11-2014 |
20140361157 | METHOD OF DETERMINING THE CONCENTRATION OF AN ELEMENT IN A SOLID USING RELATIVE ABUNDANCES OF ISOTOPES FROM THE SOLID AND A REFERENCE SOLID - A method of determining the concentration of an element of interest in a solid of interest based on the ratio of the measured relative abundances of two isotopes in the solid of interest, one isotope of the element of interest and the second isotope from an element represented in the chemical formula of the solid of interest, and comparing this ratio to the ratio of the measured relative abundances of the same two isotopes for a reference solid for which the concentration of the element of interest is known. A method of calculating the concentration of the element of interest in the solid of interest. A method of executing a computer software program with instructions for calculating the concentration of the element of interest in the solid of interest. | 12-11-2014 |
20140361158 | Methods for Predictive Automatic Gain Control for Hybrid Mass Spectrometers - A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising (i) performing a survey mass analysis, using a first mass analyzer employing indirect detection of ions by image current detection, to measure a flux of ions having m/z ratios within said range and (ii) performing a dependent mass analysis, using a second mass analyzer, of an optimal quantity of ions having m/z ratios within said range, said optimal quantity collected for a time period determined by the measured ion flux, the method characterized in that: the time period is determined using a corrected ion flux that includes a correction that comprises an estimate of the quantity of ions that are undetected by the first mass analyzer. | 12-11-2014 |
20140361159 | Isotopic Pattern Recognition - A measure of abundance is determined for an element or element combination within a sample, the element or element combination having at least one isotopic variant. An isotopic mass spectral pattern is identified for the element or element combination that indicates an expected abundance and expected mass-to-charge ratio difference for each isotopic variant. These are identified relative to the respective abundance and mass-to-charge ratio of a principal isotope. The isotopic mass spectral pattern is compared with mass spectral data from a molecular mass analysis of the sample to identify peak groups, each matching the isotopic mass spectral pattern. A measure of abundance is determined for the element or element combination as a function of the intensity measurement of one or more peaks from each of the identified peak groups. | 12-11-2014 |
20140361160 | METHODS FOR DETECTING LACOSAMIDE BY MASS SPECTROMETRY - Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample. | 12-11-2014 |
20140361161 | ANALYSER ARRANGEMENT FOR PARTICLE SPECTROMETER - The present invention relates to a method for determining at least one parameter related to charged particles emitted from a particle emitting sample. The method comprises guiding a beam of charged particles into an entrance of a measurement region by means of a lens system, and detecting positions of the particles indicative of said at least one parameter within the measurement region. Furthermore, the method comprises deflecting the particle beam at least twice in the same coordinate direction before entrance of the particle beam into the measurement region. Thereby, both the position and the direction of the particle beam at the entrance of the measurement region can be controlled in a way that to some extent eliminates the need for physical manipulation of the sample. This in turn allows the sample to be efficiently cooled such that the energy resolution in energy measurements can be improved. | 12-11-2014 |
20140361162 | IMAGING MASS SPECTROMETER AND A METHOD OF MASS SPECTROMETRY - An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process. | 12-11-2014 |
20140367564 | Method of Avoiding Space Charge Saturation Effects in an Ion Trap - A mass spectrometer is provided comprising a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects. | 12-18-2014 |
20140367565 | Method of Screening a Sample for the Presence of One or More Known Compounds of Interest and a Mass Spectrometer Performing this Method - A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation. A determination is made whether a candidate parent ion of interest is present in a non-fragmentation data set and whether one or more corresponding fragment ions of interest are present in a fragmentation data set. A further determination is made to check if the candidate parent ion of interest and the one or more corresponding fragment ions of interest have substantially similar elution or retention times and/or ion mobility drift times. | 12-18-2014 |
20140374583 | ELECTRON IONIZATION (EI) UTILIZING DIFFERENT EI ENERGIES - Mass spectrometry is performed utilizing an electron ionization (EI) source. The EI source ionizes a sample at different electron energies, including below and above 70 eV. The EI source may be utilized for soft ionization as well as hard ionization. The value of the electron energy may be selected so as to favor the formation of molecular ions or other ions of high analytical value. The ion source may be an axial ion source. | 12-25-2014 |
20140374584 | SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS - A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness. | 12-25-2014 |
20140374585 | ION GROUP IRRADIATION DEVICE, SECONDARY ION MASS SPECTROMETER, AND SECONDARY ION MASS SPECTROMETRY METHOD - The present invention provides an ion group irradiation device for irradiating a sample with an ion group, comprising: an ion group selecting unit configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses; and a primary ion irradiation unit configured to irradiate the sample with the at least two ion groups selected by the ion group selecting unit, wherein the ion group selecting unit selects at least one ion group and further selects the at least two ion groups from each of the selected at least one ion group. | 12-25-2014 |
20140374586 | ION GROUP IRRADIATION DEVICE, SECONDARY ION MASS SPECTROMETER, AND SECONDARY ION MASS SPECTROMETRY METHOD - Provided is an ion group irradiation device for facilitating the distinction of peaks in secondary ion mass spectra. The ion group irradiation device for irradiating a sample with an ion group includes an ion source for generating ions, an ion group selecting unit configured to select, from the ions released from the ion source, two or more ion groups formed of ions having different average masses, and a primary ion irradiation unit configured to irradiate the sample with the two or more ion groups. Further, an atom species or a molecule species of the ions forming the two or more ion groups is common between ion groups. | 12-25-2014 |
20140374587 | ION GROUP IRRADIATION DEVICE AND SECONDARY ION MASS SPECTROMETER - The present invention provides an ion group irradiation device which includes: an ion source which generates an ion; and an ion group selecting unit which selects an ion group containing a cluster ion from ions released from the ion source, in an ion group irradiation device for irradiating a sample with the ion group, wherein the ion source has a pressure gradient forming unit for changing a pressure with which a material of the cluster ion is jetted, with time, the ion group selecting unit has a chopper which performs a chopping operation of selecting the ion group by passing and blocking the cluster ions in a traveling direction by the opening and closing of the chopper, and the chopper performs two or more times of the chopping operations per one time of a pressure gradient forming operation by the pressure gradient forming unit. | 12-25-2014 |
20140374588 | METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER - A method and apparatus is provided including an ion source for generating ions, a vacuum chamber having an inlet aperture for receiving ions and an exit aperture for passing ions from the vacuum chamber. At least one ion guide is provided between the inlet and exit apertures, the at least one ion guide having an entrance end and an exit end. The at least one ion guide having an inner cylinder and an outer cylinder. The inner cylinder having a plurality of sections, each section having a different number of slots and the inner cylinder coaxially disposed within the outer cylinder wherein the inner cylinder is configured to generate more than one multipole field. A power supply is provided for providing an RF voltage between the outer and inner cylinders. | 12-25-2014 |
20140374589 | METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER - Ions are generated in a high pressure region and are passed into a vacuum chamber having an inlet and an exit aperture. The configuration of the inlet aperture and the pressure difference between the high pressure region and the vacuum chamber provides a supersonic free jet expansion that has a barrel shock of predetermined diameter. At least one ion guide is provided between the inlet and exit apertures having a predetermined cross-section defining an internal volume wherein the cross-section of the at least one ion guide is sized to be at least 50% of the predetermined diameter of the barrel shock of the supersonic free jet expansion. An RF voltage is provided to the at least one ion guide. Radial gas conductance is reduced in a first section of the at least one ion guide for damping shock waves resulting from the supersonic free jet expansion. | 12-25-2014 |
20140374590 | APPARATUS AND METHOD FOR CROSS-FLOW ION MOBILITY SPECTROMETRY - A cross-flow ion mobility spectrometer consists of two parallel plates defining a volume between them. Analyte ions flow along an axis from an entrance end to an exit end through the volume. An RF confining field tends to guide ions along the axis. An analytical gas flow is established orthogonal to the axis. A DC electrostatic analytical field is oriented in opposition to the analytical gas flow such that the “drag force” on ions of the selected mobility due to the analytical gas flow is balanced by the force on the ions due to the electrostatic analytical field. The selected ions are thereby able to follow a stable path to the exit end of the cross-flow mobility analyzer. However, the force on ions of other than the selected mobility is unbalanced and these ions are deflected and lost. | 12-25-2014 |
20150008312 | GENERATION OF REAGENT IONS FOR ION-ION REACTIONS - An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as PTRs and ETD using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., PTRs and/or ETD. | 01-08-2015 |
20150008313 | IONIZATION WITH FEMTOSECOND LASERS AT ELEVATED PRESSURE - The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 TW/cm | 01-08-2015 |
20150008314 | DIAGNOSTIC AND PROGNOSTIC BIOMARKERS FOR CANCER - A method for detecting cancer from a biological sample previously withdrawn from the subject, in a subject includes determining in vitro the level of at least one biomarker in the biological sample. The at least one biomarker includes a phospholipid or a free fatty acid. A level of the at least one biomarker that is 2-fold greater than the level of at least one biomarker in a control is indicative of cancer in the subject. | 01-08-2015 |
20150008315 | APPARATUS AND METHOD FOR SAMPLING OF CONFINED SPACES - In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container. | 01-08-2015 |
20150014522 | FIRST AND SECOND ORDER FOCUSING USING FIELD FREE REGIONS IN TIME-OF-FLIGHT - In some embodiments, a time of flight mass spectrometer can comprise an input orifice for receiving ions, a first ion accelerator stage for accelerating the ions along a first path, at least one ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path, a detector for detecting at least a portion of the ions redirected by said at least one ion reflector, and at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector. In some embodiments, the lengths of the field free drift regions can be selected so as to provide 1st and 2nd order corrections of the time of flight of the ions with respect to variation in their initial positions. | 01-15-2015 |
20150014523 | METHOD FOR DETERMINING THE MAXIMUM MASS PEAK IN MASS SPECTROMETRY - A fast method for determining molecular mass using mass spectrometry has the following steps: specifying a first adjusting value (M1) of the mass spectrometer, recording the associated signal amplitude (A1), specifying a second adjusting value (M2) which is different to the first, measuring the associated second signal amplitude (A2), specifying a third adjusting value (M3) which is different to the first (M1) and the second (M2) adjusting value, measuring the associated third signal amplitude (A3), determining a quadratic function containing the measured amplitude values as y-values and the specified adjusting values as x-values, determining the maximum of the quadratic function, wherein the searched adjusting value is determined from the x-value of the maximum. | 01-15-2015 |
20150021469 | Interfacing Capillary Electrophoresis to a Mass Spectrometer via an Impactor Spray Ionization Source - A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebuliser and a target. Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target so as to ionise the analyte to form a plurality of analyte ions. | 01-22-2015 |
20150021470 | METHOD FOR IMAGING MASS ANALYSIS USING PHYSICAL VAPOR DEPOSITION OF PLATINUM NANOPARTICLES - The present invention provides an improved method for imaging mass spectrometry using an ionization-assisting matrix of a test sample, wherein the ionization efficiency is high, migration and visual information reduction are inhibited, no interference peaks originating from the matrix occur, and the analysis can be performed at high spatial resolution. | 01-22-2015 |
20150021471 | Electrostatic Mass Spectrometer With Encoded Frequent Pulses - A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E-trap sensitivity. | 01-22-2015 |
20150028197 | MULTI-REFLECTION MASS SPECTROMETER - A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction, the X direction being orthogonal to Y, characterized in that the mirrors are not a constant distance from each other in the X direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer. The motion of ions along the drift direction is opposed by an electric field resulting from the non-constant distance of the mirrors from each other along at least a portion of their lengths in the drift direction that causes the ions to reverse their direction. | 01-29-2015 |
20150028198 | MULTI-REFLECTION MASS SPECTROMETER - A multi-reflection mass spectrometer comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (Y), each mirror opposing the other in an X direction and having a space therebetween, the X direction being orthogonal to Y; the mass spectrometer further comprising one or more compensation electrodes each electrode being located in or adjacent the space extending between the opposing mirrors; the compensation electrodes being configured and electrically biased in use so as to produce, in at least a portion of the space extending between the mirrors, an electrical potential offset which: (i) varies as a function of the distance along the drift length, and/or; (ii) has a different extent in the X direction as a function of the distance along the drift length. In a preferred embodiment the period of ion oscillation between the mirrors is not substantially constant along the whole of the drift length. | 01-29-2015 |
20150028199 | SYSTEM AND METHOD FOR GROUPING PRECURSOR AND FRAGMENT IONS USING SELECTED ION CHROMATOGRAMS - LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group. | 01-29-2015 |
20150028200 | Ion Mobility Separator with Variable Effective Length - An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field and/or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator. | 01-29-2015 |
20150034813 | Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis - A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react. | 02-05-2015 |
20150034814 | MALDI Imaging and Ion Source - An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror. | 02-05-2015 |
20150034815 | METHOD FOR MASS SPECTROMETRY - A method is provided for mass spectrometry. The method includes generating precursor ions from a sample; transmitting the precursor ions into a collision cell; generating product ions in the collision cell; detecting the precursor and product ions; applying modulation to one or more of the precursor ion intensity and the product ion intensity; and identifying precursor ion and product ion relationships by analyzing intensity profiles defined by the modulation. | 02-05-2015 |
20150034816 | INTERFACE FOR MASS SPECTROMETRY APPARATUS - There is provided an interface for use in sampling ions in a mass spectrometer, the interface being arranged for receiving a quantity of ions from an ion source and forming more than one ion beam therefrom, each ion beam being directed along a respective desired pathway. | 02-05-2015 |
20150034817 | IONIZATION DEVICE, MASS SPECTROMETRY APPARATUS, MASS SPECTROMETRY METHOD, AND IMAGING SYSTEM - A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions. | 02-05-2015 |
20150034818 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE - A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure. | 02-05-2015 |
20150034819 | Multiple Channel Detection for Time of Flight Mass Spectrometer - An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons. The output from each photodiode is connected to a separate Time to Digital Converter provided on an ASIC. | 02-05-2015 |
20150041634 | CHARACTERIZATION AND PREDICTION OF JET FUEL QUALITY - Systems and methods are provided for characterizing kerosene fractions in order to determine whether the fractions will satisfy a desired thermal breakpoint specification. Additionally, hydrotreating conditions can be determined that will result in a hydrotreated kerosene fraction that satisfies the desired thermal breakpoint specification. The hydrotreating conditions can be determined based on a model constructed from data corresponding to a plurality of reference samples. The model can include data for compositional groups within the reference samples. The data for compositional groups can be derived from Fourier transform ion cyclotron resonance mass spectrometry data or from another suitable characterization technique. | 02-12-2015 |
20150041635 | Time of Flight Quantitation Using Alternative Characteristic Ions - A method of mass spectrometry is disclosed wherein the intensity of an analyte is determined by determining the intensity of first characteristic fragment ions when the intensity of the first characteristic fragment ions is within a first intensity range corresponding to the detection or unsaturated range of an ion detector. However, when the intensity of the first characteristic fragment ions is outside of the first intensity range so that the ion detector would saturate then the intensity of the analyte is determined by determining the intensity of second different characteristic fragment ions. | 02-12-2015 |
20150041636 | Multi-Dimensional Survey Scans For Improved Data Dependent Acquisitions - A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property (e.g. ion mobility) and then separating the parent ions according to a second physico-chemical property (e.g. mass to charge ratio). A plurality of parent ions of interest are then determined from the initial multi-dimensional survey scan. Once parent ions of interest have been determined, the plurality of parent ions of interest are sequentially selected based upon the first and second physico-chemical properties during a single cycle of separation. The parent ions of interest may then be fragmented and corresponding fragment ions may then be mass analysed. | 02-12-2015 |
20150041637 | ION MOBILITY SPECTROMETER AND METHOD OF OPERATING SAME - In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, for any integer M greater than 1, a method of separating ions repeats the following multiple times to cause only ions entering the drift tube that have a predefined ion mobility or range to traverse the drift tube: for each integer N beginning with 1 and sequentially advancing to M, establishing for a time duration an Nth electric repulsive field in the Nth ion elimination region and in every following Mth ion elimination region and an Nth electric drift field in each remaining ion elimination region and in each drift tube segment while deactivating for the time duration all non-Nth electric drift fields and non-Nth electric repulsive fields in each of the ion elimination regions and drift tube segments. | 02-12-2015 |
20150041638 | ION GENERATION USING MODIFIED WETTED POROUS MATERIALS - The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. | 02-12-2015 |
20150048244 | MATERIAL INSPECTION APPARATUS AND MATERIAL INSPECTION METHOD - A material inspection apparatus according to the present embodiment includes a sample mount capable of mounting a sample. A detector detects an atom desorbed from the sample. A voltage generator applies a voltage to the sample. A laser generator irradiates a laser beam onto the sample. An arithmetic part processes a detection result of the detector. A storage part stores a detection prediction range of a certain element and an isotope of the certain element. A display displays the detection prediction range and an actual detection result of the detector in a comparable manner. | 02-19-2015 |
20150048245 | Ion Optical System For MALDI-TOF Mass Spectrometer - An ion accelerator for a time-of-flight mass spectrometer includes a pulsed ion accelerator positioned proximate to a sample plate and having an electrode that is electrically connected to the sample plate. An accelerator power supply generates an accelerating potential on the ion accelerator electrode that accelerates a pulse of ions generated from the sample positioned on the sample plate. An ion focusing electrode is positioned after the pulsed ion accelerator. A potential applied to the ion focusing electrode focuses the pulse of ions into a substantially parallel beam propagating in an ion flight path. A static ion accelerator is positioned proximate to the ion focusing electrode with an input that receives the pulse of ions focused by the ion focusing electrode. The static ion accelerator accelerating the focused pulse of ions. | 02-19-2015 |
20150053852 | METHOD FOR DIAGNOSING STOMACH CANCER USING CHANGE OF TRYPTOPHAN METABOLISM - The present disclosure relates to stomach cancer diagnosis using tryptophan metabolism rate in one aspect, and it relates to an invention using change of tryptophan metabolism rate in a stomach cancer patient, which is different from a normal person. | 02-26-2015 |
20150053853 | Plume Collimation for Laser Ablation Electrospray Ionization Mass Spectrometry - In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described. | 02-26-2015 |
20150053854 | SYSTEMS AND METHODS EXTENDING THE LASERSPRAY IONIZATION MASS SPECTROMETRY CONCEPT FROM ATMOSPHERIC PRESSURE TO VACUUM - Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry. | 02-26-2015 |
20150060656 | ION DEFLECTION IN TIME-OF-FLIGHT MASS SPECTROMETRY - A time-of-flight mass spectrometry (TOF MS) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor. The deflector deflects ions away from a main flight path such that the defected ions are not detected. | 03-05-2015 |
20150060657 | MS/MS Analysis Using ECD or ETD Fragmentation - A method of mass spectrometry is disclosed comprising providing a mixture of different analyte ions and supplying electrons or reagent ions to said mixture so as to transfer charge to the analyte ions. The transfer of charge causes at least some of the analyte ions to dissociate and others of the analyte ions not to dissociate, but to form intermediate ions of altered charge state. These intermediate ions are then isolated from other ions and excited so as to dissociate into daughter ions. The intermediate ions and their daughter ions are analysed and associated with each other so that the intermediate can be identified from their daughter ions. The analyte ions can then be identified from the intermediate ions, since they differ only in charge state. The disclosed method enables analyte ions to be associated with their fragment ions, and therefore identified, without having to isolate individual analyte ions prior to their interactions with the electrons or reagent ions. | 03-05-2015 |
20150060658 | Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection - A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated. | 03-05-2015 |
20150060659 | VITAMIN B2 DETECTION BY MASS SPECTROMETRY - Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques. | 03-05-2015 |
20150069226 | MASS SPECTROMETRY METHOD OF PHOSPHORYLATED PEPTIDES AND SUGAR CHAINS - The present invention provides a method for mass spectrometry of phosphorylated peptides or sugar chains, which suppresses the desorption of an unstable site during ionization and achieves high sensitivity (i.e., detects molecular-related ions at a high ionic strength and at a relatively higher ionic strength than other ion species derived from the desorption of an unstable site). A method for mass spectrometry of phosphorylated peptides or sugar chains, the method comprising using, as a liquid matrix, an ionic liquid comprising a 3-aminoquinoline ion and a p-coumaric acid ion. The liquid matrix comprises 3-aminoquinoline and p-coumaric acid, for example, in a molar ratio of 5:1 to 20:1. Ammonium phosphate may be used as an additive. | 03-12-2015 |
20150069227 | HIGH PERFORMANCE ION MOBILITY SPECTROMETER APPARATUS AND METHODS - An ion mobility spectrometry method wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. Ion mobility spectrometer operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation. | 03-12-2015 |
20150069228 | SELECTIVE ION MOBILITY SPECTROMETER FORMED FROM TWO CONSECUTIVE MASS SELECTIVE FILTERS - Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier. | 03-12-2015 |
20150076339 | SMS PROBE AND SEM IMAGING SYSTEM AND METHODS OF USE - SMS probe imaging systems, methods of use thereof, and the like are disclosed. Embodiments of the present disclosure can use direct interrogation of objects (e.g., cells or tissue) within a small pool/droplet of liquid, optional thermal, mechanical, electrical, optical and chemical manipulation, followed immediately by liquid sampling, optional sample conditioning, and soft ionization of biomolecules. | 03-19-2015 |
20150076340 | MASS SPECTROMETRIC ANALYSIS USING NANOPARTICLE MATRICES - Methods of characterizing an analyte of interest are provided. The methods can involve using a population of nanoparticles (e.g., magnetic ferrite nanoparticles) as a matrix for matrix-assisted laser desorption ionization (MALDI) mass spectrometry. The size, shape, and composition of the nanoparticles can be selected in view of a variety of factors, including the nature of the analyte of interest, the desired characteristics of the mass spectrum, the nature of the energy directed onto the target composition, and combinations thereof. The nanoparticle matrix can enhance MALDI analysis by providing a cleaner mass spectral background and/or inducing abundant fragmentation of analyte ions by in-source decay (ISD). The nanoparticles are also versatile and selective; the nanoparticle matrix can be tuned to render the matrix particles compatible with an analyte of interest and/or improve selectivity for an analyte of interest. | 03-19-2015 |
20150076341 | Method Of Mass Spectrometry And A Mass Spectrometer - The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas. | 03-19-2015 |
20150083906 | BIOMARKERS FOR MONITORING INTERVENTION THERAPIES FOR DIABETES - The use of N-linked glycosylation pattern of serum proteins as a biomarker for evaluating the efficacy of intervention therapies for diabetes is disclosed. As disclosed herein, changes in the N-linked glycosylation of total plasma proteins precedes and predicts the decrease in glycated hemoglobin (HbA1c) associated with successful treatment of diabetes. Therefore, measuring changes in N-linked glycosylation of total serum plasma proteins over time may be used as a biomarker to evaluate or access the efficacy of an intervention therapy for diabetes. | 03-26-2015 |
20150090873 | Method of Single Point Internal Lock-Mobility Correction - A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions. | 04-02-2015 |
20150090874 | METHOD AND APPARATUS TO PROVIDE PARALLEL ACQUISITION OF MASS SPECTROMETRY/MASS SPECTROMETRY DATA - A system and method for acquisition of mass spectrometry data is configured to provide a stream of charged particles (e.g., from an analytical volume). A primary mass spectrometer (e.g., time-of-flight mass spectrometer) may be used to separate charged particles of the stream of charged particles based on their mass-to-charge ratio and detect the charged particles in a mass-to-charge spectrum. A stream of precursor ions having a selected mass range may be diverted from the stream of charged particles for fragmentation to provide fragment ions (e.g., fragment ions from the analytical volume). The fragment ions may be provided to a second mass spectrometer for analysis of the fragment ions (e.g., during the same time as the time-of-flight mass spectrometer is separating and detecting charged particles of the stream of charged particles based on their mass-to-charge ratio). | 04-02-2015 |
20150090875 | Method of MS Mass Spectrometry - A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are analysed and a second mode in which parent ions are fragmented and their fragment ions are mass analysed. In the first mode the parent ions are charge reduced before being analysed, so as to simplify the parent ion spectral data obtained. In the second mode, the parent ions are not charge reduced prior to fragmentation, so that it remains relatively easy to induce the parent ions to fragment. The parent ions are then associated with their fragment ions using the mass spectral data obtained. | 04-02-2015 |
20150090876 | Method to Detect and Sequence Post Translationally Modified Peptides - A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed. | 04-02-2015 |
20150097113 | Modulation of Instrument Resolution Dependant upon the Complexity of a Previous Scan - Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample. | 04-09-2015 |
20150097114 | Excitation of Reagent Molecules Withn a RF Confined Ion Guide or Ion Trap to Perform Ion Molecule, Ion Radical or Ion-Ion Interaction Experiments - A mass spectrometer is disclosed comprising an RF ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the RF ion guide or ion trap. The mass spectrometer further comprises a photo-ionisation device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the RF ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionisation device to photo-ionise and/or photo-excite the reagent gas to form reagent ions, excited species or radical species. The reagent ions, excited species or radical species interact with at least some of the neutral molecules located within the RF ion guide or ion trap to form analyte ions. | 04-09-2015 |
20150102214 | IDENTIFICATION OF SURGICAL SMOKE - A method includes assessing tumor margins and discriminating between tumor and non-tumor tissues by analyzing the compositional make-up of smoke produced during cautery resection of tissues. | 04-16-2015 |
20150102215 | Collision Cell Multipole - Mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion. A low-mass cut-off of the multipole may be controlled by varying a q value from a first to at least a second value. The multipole may have multipole electrodes disposed about a central axis and having a respective first portion, second portion, and intermediate portion therebetween which is radially closer to the central axis. This offers relatively high acceptance and ion transmission, while providing low-mass cut-off for removing undesired/interfering ions and helping reduce background count. | 04-16-2015 |
20150102216 | Classification Generation Method Using Combination of Mini-Classifiers with Regularization and Uses Thereof - A method for classifier generation includes a step of obtaining data for classification of a multitude of samples, the data for each of the samples consisting of a multitude of physical measurement feature values and a class label. Individual mini-classifiers are generated using sets of features from the samples. The performance of the mini-classifiers is tested, and those that meet a performance threshold are retained. A master classifier is generated by conducting a regularized ensemble training of the retained/filtered set of mini-classifiers to the classification labels for the samples, e.g., by randomly selecting a small fraction of the filtered mini-classifiers (drop out regularization) and conducting logistical training on such selected mini-classifiers. The set of samples are randomly separated into a test set and a training set. The steps of generating the mini-classifiers, filtering and generating a master classifier are repeated for different realizations of the separation of the set of samples into test and training sets, thereby generating a plurality of master classifiers. A final classifier is defined from one or a combination of more than one of the master classifiers. | 04-16-2015 |
20150102217 | INTRODUCTION OF IONS INTO ION CYCLOTRON RESONANCE CELLS - The invention relates to a method and a device for introducing ions into an ICR cell of Fourier transform ion cyclotron resonance mass spectrometers, in particular with a reduced the magnetron orbit. The invention is based on applying at least one gated DC voltage to a mantle electrode of the ICR cell prior to the excitation of the cyclotron motion such that injected ions are deflected inside the ICR cell in at least one radial direction. | 04-16-2015 |
20150102218 | SYSTEMS AND METHODS FOR SAMPLE ANALYSIS - The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer. | 04-16-2015 |
20150108342 | EXTRACTION AND DETECTION SYSTEM AND METHOD - An apparatus, system and method for the continuous flow extraction, collection and analysis of small amounts of energetic substance/s and their reacted/unreacted residue/s in real time are provided. The apparatus includes an agitator that generates a particulate material from a surface. A vacuum gathers particulate material which is provided to a mixing module. The mixing module creates a supercritical matrix containing the particulate matter. A separator separates and removes waste in the supercritical matrix from the supercritical matrix. Concentrated particulate material from the supercritical matrix is provided to a mass spectrometer for analysis and detection of a target material in proximate real-time. In one embodiment, the separator provides the supercritical matrix to a tube arm. The tube arm is heated to reduce solvent in the supercritical matrix. A collector in the tube arm concentrates particulate material, which is volatilized by a laser. Volatilized particulate material is provided to the mass spectrometer. In another embodiment, the separator provides the supercritical matrix to an electrospray or APCI module whose output is provided direct to the mass spectrometer. | 04-23-2015 |
20150108343 | METHODS FOR SELECTIVE DETECTION OF BIOLOGICALLY RELEVANT ACIDS - Methods and systems for performing ion mobility spectrometry are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of biologically relevant acids that may be difficult to separate with conventional MS techniques. In various aspects, methods and systems in accordance with applicant's teachings can enable a differential mobility spectrometer to resolve biologically relevant acids through the use of CO | 04-23-2015 |
20150108344 | Multipurpose Mass Spectrometric Assay Panels for Peptides - Methods are provided for estimating the relative amounts of identifiable compartments, such as different types of cells or cell components, within a biological sample. The methods use mass spectrometric analysis in quantitate compartment-specific molecules and thereby allow calculation of the amount of each compartment that is present in a biological sample. The methods can, for example, provide a measurement of hematocrit from a dried blood sample. | 04-23-2015 |
20150115147 | DRIFT TUBE ION MOBILITY SPECTROMETER FOR AEROSOL MEASUREMENT - A drift tube ion mobility spectrometry sample introduction scheme allows introduction of a sample packet at ground voltages. The sample packet of ionized particles is captured by subjecting particles within a defined region to an electric field at an elevated voltage. The ionized particles in the captured packet then migrate through the drift tube down the voltage gradient according to their electrical mobility. The particles are directed to a high sensitivity detector, such as a condensation particle counter (CPC), for detection. | 04-30-2015 |
20150115148 | MASS DISTRIBUTION MEASUREMENT METHOD AND MASS DISTRIBUTION MEASUREMENT APPARATUS - Projection TOF mass spectrum distribution information is acquired by irradiating a first ionizing beam onto a surface of a specimen to acquire first mass spectrum distribution information on secondary ions generated from the specimen, irradiating a second ionizing beam onto the same surface to acquire second mass spectrum distribution information on secondary ions generated from the specimen irradiation, and correcting the second mass spectrum distribution information by correcting time-of-flight distribution information of secondary ions in the second mass spectrum distribution information on the basis of detection time distribution of an arbitrary peak in the first mass spectrum distribution information. | 04-30-2015 |
20150115149 | MASS DISTRIBUTION MEASUREMENT METHOD AND MASS DISTRIBUTION MEASUREMENT APPARATUS - Projection TOF mass spectrum distribution information is acquired by irradiating a first ionizing beam onto a surface of a specimen to acquire first mass spectrum distribution information on secondary ions generated from the specimen, irradiating a second ionizing beam onto the same surface to acquire second mass spectrum distribution information on secondary ions generated from the specimen, and correcting the second mass spectrum distribution information on the basis of the first mass spectrum distribution information. | 04-30-2015 |
20150115150 | KISSPEPTIN-54 DETECTION BY TANDEM MASS SPECTROMETRY - Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques. | 04-30-2015 |
20150122985 | PLASMA-BASED ELECTRON CAPTURE DISSOCIATION (ECD) APPARATUS AND RELATED SYSTEMS AND METHODS - An electron capture dissociation (ECD) apparatus includes a plasma source for generating plasma. Analyte ions are exposed to the plasma in an ECD interaction region, either inside or outside the plasma source. The apparatus may include one or more devices for refining the plasma in preparation for interaction with the analyte ions. Refining may entail removing unwanted species from the plasma, such as photons, metastable particles, neutral particles, and/or high-energy electrons unsuitable for ECD, and/or controlling a density of low-energy electrons in the plasma. | 05-07-2015 |
20150122986 | MASS SPECTROMETER WITH LASER SPOT PATTERN FOR MALDI - The invention relates to mass spectrometers with an ion source, comprising a UV laser system for mass spectrometric analyses with ionization of analyte molecules in a sample by matrix-assisted laser desorption, which, with very low energy losses, can produce a spatially distributed spot pattern with several intensity peaks of equal height, thus making it possible to achieve an optimum degree of ionization of analyte ions for any task. Such a spot pattern can be generated from the UV beam with high transverse coherence, using a combination of a lens array and a lens, provided that the lens array satisfies a mathematical condition for separation of the micro-lenses from each other (pitch) and their focal length. For example, a lens array with square or round lenses produces a pattern of nine and five spots, respectively. The lens arrays are inexpensive and do not require any lateral adjustment in this arrangement. | 05-07-2015 |
20150122987 | ION GENERATION USING WETTED POROUS MATERIAL - The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent. | 05-07-2015 |
20150122988 | CHROMATOGRAPHY APPARATUS AND METHODS USING MULTIPLE MICROFLUIDIC SUBSTRATES - An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal. | 05-07-2015 |
20150129757 | Systems and Methods for Using Variable Mass Selection Window Widths in Tandem Mass Spectrometry - Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample. | 05-14-2015 |
20150129758 | Systems and Methods for Sequencing Peptides by Mass Spectrometry - The number of atoms present in an ion of a molecule is identified using a mixture of different forms of the molecule. A mass spectrometer analyzes a mixture of at least two forms of the molecule using one or more ion scans producing a mass spectrum. The first form of the molecule includes a first combination of isotopes of one or more elements. The second form of the molecule includes a second combination of isotopes of the one or more elements. A first peak and a second peak that differ in mass by a multiple of a mass difference between the first combination of isotopes and the second combination of isotopes are located in the mass spectrum. The number of atoms of the one or more elements present in an ion of the molecule is identified from a mass difference between the first peak and the second peak. | 05-14-2015 |
20150129759 | INDUCTIVELY-COUPLED PLASMA ION SOURCE FOR USE WITH A FOCUSED ION BEAM COLUMN WITH SELECTABLE IONS - An inductively coupled plasma source having multiple gases in the plasma chamber provides multiple ion species to a focusing column. A mass filter allows for selection of a specific ion species and rapid changing from one species to another. | 05-14-2015 |
20150129760 | METHODS AND DEVICES FOR CALIBRATING THE MOBILITY AXIS OF AN ION MOBILITY SPECTRUM - Methods and devices are provided for calibrating the mobility axis of an ion mobility spectrum and determining the mobility characteristic of ion species from an ion mobility spectrum, in particular for calibrating the drift time axis of an ion mobility spectrum acquired by a drift type ion mobility spectrometer (IMS). An ion mobility spectrometer uses an ion source that comprises a first ionization region which is fluidly coupled to a sample source, a second ionization region which is spatially separated from the first ionization region and fluidly coupled to a calibrant reservoir, and electrical means for controlling the transfer of sample ions from the first region into the second ionization region or into a third region of the ion source wherein the third region is fluidly coupled to the first and second ionization region and located closer to a mobility analyzer than the first and second ionization region. | 05-14-2015 |
20150129761 | USE OF CRYOGENIC ION CHEMISTRY TO ADD A STRUCTURAL CHARACTERIZATION CAPABILITY TO MASS SPECTROMETRY THROUGH LINEAR ACTION SPECTROSCOPY - The present invention relates to mass spectrometry and infrared spectrometry and in particular, to a method of providing highly resolved infrared spectra of mass-selected, complex (e.g., biopolymer, polypeptide, organic chemical, an organometallic compound, a carbohydrate, a polynucleotide or oligonucleotide compound) ions to be obtained in a general fashion. | 05-14-2015 |
20150136968 | Systems and Methods for Using Interleaving Window Widths in Tandem Mass Spectrometry - Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width. | 05-21-2015 |
20150136969 | Method of Identifying Precursor Ions - A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyser; and using the start and end times at which the precursor ion is transmitted by said mass analyser to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyser is used to analyse the precursor ions. | 05-21-2015 |
20150136970 | Orthogonal Acceleration Coaxial Cylinder Time of Flight Mass Analyser - A Time of Flight mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector. | 05-21-2015 |
20150136971 | Calibrating Dual ADC Acquisition System - A method of calibrating a dual gain ADC detector system is disclosed comprising passing a test signal through a high gain signal path to produce a first signal and passing a test signal through a low gain signal path to produce a second signal. A time difference between the first signal and the second signal is then determined. Data from the two ADCs is then stitched to form a composite mass spectrum without needing to correct the phase between the two ADCs. | 05-21-2015 |
20150136972 | ANALYSIS OF MICROBES BY MALDI MASS SPECTROMETRY - The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (MALDI). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as MALDI samples. The ionization by matrix-assisted laser desorption also takes place on the contact surface. | 05-21-2015 |
20150136973 | PULSED ION BEAM SOURCE FOR ELECTROSPRAY MASS SPECTROMETRY - Apparatus and methods for creating a pulsed ion beam. The pulsed ion beam can be used for performing mass spectrometry. A pulsed solenoid valve can provide a pulsed ion beam from an electrospray in a pre-vacuum chamber. The pulsed ion beam can enter a high vacuum region and a mass analyzer for mass spectrometry. | 05-21-2015 |
20150144777 | MULTIPLE SOLID PHASE MICRO-EXTRACTION THERMAL DESORPTION IONIZATION DEVICE, MASS SPECTROMETER AND ANALYTICAL METHOD FOR MASS SPECTROMETRY - A multiple solid phase microextraction (m-SPME) thermal desorption ionization device which desorbs an analyte and moves it into an entry of a mass spectrometer for mass spectrometry analysis is provided. The device has a charge producing unit, a heating unit and a sampling unit. The sampling unit provides a plurality of probes. The analyte is attached to the probes, and then the probes are inserted through a passage of the heating unit to instantly vaporize the analyte for ionization and analysis in conjunction with the charge producing unit and the mass spectrometer. Thus, the time needed for analyte analysis is shortened. A mass spectrometer system having the thermal desorption ionization device and an analytical method for mass spectrometry are also provided. | 05-28-2015 |
20150144778 | Data Independent Acquisition of Product Ion Spectra and Reference Spectra Library Matching - Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored. | 05-28-2015 |
20150144779 | Electron Impact Ion Source With Fast Response - A closed electron impact ion source with overall opening area of less than 30 mm | 05-28-2015 |
20150144780 | Method of MS/MS Mass Spectrometry - A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to Electron Capture Dissociation (“ECD”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure. | 05-28-2015 |
20150144781 | METHOD AND APPARATUS FOR CONTROLLING THE SUPPLY OF IONS - A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources. The ion source can be operated in two modes: a mode in which ions are supplied into the mass spectrometer and a mode in which ions are prevented to be supplied into the mass spectrometer. In this latter mode, the supply of ions into the mass spectrometer is prevented by reducing the potential applied to the ionization source, reducing the nebulizer gas flow and/or increasing the cone gas flow. | 05-28-2015 |
20150144782 | SYSTEMS, DEVICES, AND METHODS FOR CONNECTING A CHROMATOGRAPHY SYSTEM TO A MASS SPECTROMETER - The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer. The ion source includes a first conduit for receiving eluent from the chromatography device, a heater for heating at least a portion of said first conduit, a second conduit in fluid communication with the first conduit, an inlet for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume. | 05-28-2015 |
20150293059 | METHOD AND STRUCTURE FOR CHEMICAL ANALYSIS - The invention relates to a method for chemical analysts, in which a gas flow is ionized, the ionized gas flow is led to a filtering area fitted to the flow channel, the ionized gas flow is filtered using the DMS/FAIMS method, in order to remove at least some of the ions from the gas flow. A parallel mainly non-ionized gas flow, which is on at least one side of the ionized gas flow, is led to the filtering area together with the ionized gas flow. The invention also relates to a corresponding structure. | 10-15-2015 |
20150293072 | METHODS AND SYSTEMS FOR DETERMINING AUTISM SPECTRUM DISORDER RISK - In certain embodiments, the invention stems from the discovery that analysis of population distribution curves of metabolite levels in blood can be used to facilitate predicting risk of autism spectrum disorder (ASD) and/or to differentiate between ASD and non-ASD developmental delay (DD) in a subject. In certain aspects, information from assessment of the presence, absence, and/or direction (upper or lower) of a tail effect in a metabolite distribution curve is utilized to predict risk of ASD and/or to differentiate between ASD and DD. | 10-15-2015 |
20150293116 | Ionization of Chemicals in Mixture at Low pH by Ambient Ionization/Mass Spectrometry - A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent ( | 10-15-2015 |
20150294846 | Method of Charge Reduction of Electron Transfer Dissociation Product Ions - A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine. | 10-15-2015 |
20150294847 | Mass Spectrometer With Soft Ionizing Glow Discharge and Conditioner - An ion detection system including an ion source and at least one ion detector is disclosed. The ion source includes a source housing, a reactor, first and second ionizers and a sampling channel. The first ionizer is a glow discharge ionizer. The ion detector communicates with the sampling channel. A conditioner, which is sized to remove fast diffusing electrons, connects the first glow discharge ionizer to the reactor. A corresponding method of ionization is also disclosed. The method includes ionizing and conditioning an ionizer gas, receiving the ionizer gas and analyte molecule ions into a reactor, and delivering a flow from the reactor. The conditioning of the ionizer gas removes fast diffusing electrons from the gas flow. | 10-15-2015 |
20150294848 | Ion Mobility Separator with Variable Effective Length - An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field and/or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator. | 10-15-2015 |
20150294850 | Ion Trap With Spatially Extended Ion Trapping Region - A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction. | 10-15-2015 |
20150303043 | INTELLIGENTLY CONTROLLED SPECTROMETER METHODS AND APPARATUS - The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. | 10-22-2015 |
20150303045 | Compound Identification Using Multiple Spectra at Different Collision Energies - Systems and methods are provided for compound identification using multiple spectra that are a function of a variable instrument parameter that affects the intensity of fragment ions. A plurality of acquired fragment ion spectra that are a function of a variable instrument parameter for at least one ion are received from a mass spectrometer using a processor. The at least one ion is identified by comparing rates of change of mass intensity, with respect to the variable instrument parameter, for acquired and known fragment ions using the processor. Specifically, one or more acquired rates of change calculated for acquired fragment ions from the plurality of acquired fragment ion spectra are compared with one or more known rates of change calculated for one or more stored fragment ions of one or more known compounds in a database of known compounds. | 10-22-2015 |
20150308991 | METHODS OF DETECTING REVERSE TRIIODOTHYRONINE BY MASS SPECTROMETRY - Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample. | 10-29-2015 |
20150309001 | METHODS OF ANALYZING CRUDE OIL - The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps. | 10-29-2015 |
20150311051 | Interlacing to Improve Sampling of Data When Ramping Parameters - Systems and methods are provided for interlacing ramped mass spectrometer parameter values during data acquisition. Ions from a sample are acquired within a cycle time, Ct, using a mass spectrometer. Within each Ct, two or more scans of the acquired ions are performed using two or more ramped values for a parameter of the mass spectrometer. When it is determined that scans for a desired range of ramped parameter values cannot be performed within Ct, the desired range of ramped values is divided into at least two interlaced groups of ramped values. The mass spectrometer is instructed to perform scans for each of the interlaced groups within two or more cycle times. Spectra from the scans for each of the at least two interlaced groups are combined. The ramped parameter values of the combined spectra have the desired range and the desired effective step size. | 10-29-2015 |
20150311052 | SYSTEM AND METHOD FOR GROUPING PRECURSOR AND FRAGMENT IONS USING SELECTED ION CHROMATOGRAMS - LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chromatographic peaks in mass chromatograms. After initial groupings are determined based on retention time, ion peak shapes are compared to determine whether ions should be excluded. Ions having peak shapes not matching other ions, or alternatively a reference peak shape, are excluded from the group. | 10-29-2015 |
20150311056 | HIGH SENSITIVITY ELECTROSPRAY INTERFACE - The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray. | 10-29-2015 |
20150311057 | ION GROUP IRRADIATION DEVICE, SECONDARY ION MASS SPECTROMETER, AND SECONDARY ION MASS SPECTROMETRY METHOD - The present invention provides an ion group irradiation device for irradiating a sample with an ion group. An ion group selecting unit is configured to select, from ions released from an ion source, at least two ion groups formed of ions having different average masses. A primary ion irradiation unit is configured to irradiate the sample with the at least two ion groups. | 10-29-2015 |
20150316506 | Correction of Time of Flight MS ADC Data on Push by Push Basis - A method of mass spectrometry is disclosed comprising pulsing ions into a time of flight region and detecting the ions using an ion detector. The signal output from the ion detector is digitised to produce a digitised signal. The peak area A | 11-05-2015 |
20150318154 | Scheduled MS3 for Quantitation - Systems and methods are provided for scheduled MS | 11-05-2015 |
20150318155 | Method and Apparatus for Improving Ion Transmission into a Mass Spectrometer - An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum. The vacuum chamber can be a chamber of a vacuum housing enclosing a mass analyzer. | 11-05-2015 |
20150318157 | IONIZATION DEVICE, MASS SPECTROMETRY APPARATUS, MASS SPECTROMETRY METHOD, AND IMAGING SYSTEM - A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions. | 11-05-2015 |
20150318158 | PROBE FOR EXTRACTION OF MOLECULES OF INTEREST FROM A SAMPLE - The present disclosure describes a device for generating ionized molecules for analysis in a mass spectrometer. The device includes: a mesh substrate coated with an extraction phase, the extraction phase comprising a polymer that absorbs a molecule of interest from a matrix, or a polymer and solid phase microextraction (SPME) particles having pores dimensioned to absorb a molecule of interest from a matrix, where the mesh substrate has a sufficiently open structure to allow fluid to flow through the mesh substrate; and a solid substrate connected to the mesh substrate to provide stability to the coated mesh substrate. Mass spectrometry systems that include such a device are also described. Methods of analyzing an analyte previously extracted from a matrix onto the device are also described. | 11-05-2015 |
20150318159 | SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF SELENIUM AND SILICON IN SAMPLES - The present disclosure provides methods and systems for improved detection and/or quantification of selenium (Se) and/or silicon (Si) in samples. In certain embodiment, the methods and systems feature the use of carbon dioxide (CO | 11-05-2015 |
20150318160 | PROBE FOR EXTRACTION OF MOLECULES OF INTEREST FROM A SAMPLE - A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer. The solid substrate may have at least two edges that meet at an angle from about 8° to about 180°. Mass spectrometry systems that include such a device are also described. Methods of analyzing a molecule previously extracted from a sample onto the device are also described. | 11-05-2015 |
20150318162 | Segmented Planar Calibration for Correction of Errors in Time of Flight Mass Spectrometers - An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions. The ion detector system generates separate first mass spectral data sets for each detector element and then applies a calibration coefficient to each of the first mass spectral data sets to produce a plurality of second calibrated mass spectral data sets. The plurality of second calibrated mass spectral data sets are then combined to form a composite mass spectral data set. | 11-05-2015 |
20150323513 | QUANTITATION OF TAMOXIFEN AND METABOLITES THEREOF BY MASS SPECTROMETRY - Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein comprise determining the amount of norendoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein comprise determining the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites. | 11-12-2015 |
20150325420 | ULTRAFAST TRANSIMPEDANCE AMPLIFIER INTERFACING ELECTRON MULTIPLIERS FOR PULSE COUNTING APPLICATIONS - Systems, devices, and methods are provided for an improved mass spectrometry detection system for pulse counting applications. The detector can comprise an electron multiplier and circuitry, such as a transimpedance amplifier, that allows for the gain of the detector to be decreased, which in turn leads to a pulse counting detector with a high dynamic range. In some embodiments, the detector can operate at count rates of up to about 20 million counts per second without reaching saturation. Further, the lifetime of the detector can be extended. A variety of embodiments of systems, devices, and methods in conjunction with the disclosures are provided. | 11-12-2015 |
20150325422 | Method for Ion Production - A method for producing multiply charged ions is provided. In the method, a laser is used to ablate a sample comprising a matrix and an analyte. The sample is in the liquid form when it is ablated and the ions produced are passed through a heated conduit. The multiply charged ions produced may be used in mass spectrometry to measure the mass of the analyte. | 11-12-2015 |
20150325423 | SYSTEMS AND METHODS FOR ANALYZING AN EXTRACTED SAMPLE - The invention generally relates to systems for analyzing a sample and methods of use thereof. In certain aspects, the invention provides systems that include an ionization probe and a mass analyzer. The probe includes a hollow body that has a distal tip. The probe also includes a substrate that is at least partially disposed within the body and positioned prior to the distal tip so that sample extracted from the substrate flows into the body prior to exiting the distal tip. The probe also includes an electrode that operably interacts with sample extracted from the substrate. | 11-12-2015 |
20150325425 | Multi-Electrode Ion Trap - This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes. | 11-12-2015 |
20150332904 | Parsing Events During MS3 Experiments - Systems and methods are provided for reducing the time period of a CID event of an MS | 11-19-2015 |
20150332905 | Mass Separators, Mass Selective Detectors, and Methods for Optimizing Mass Separation within Mass Selective Detectors - Mass separators are provided that can include at least one electrode component having a surface, in one cross section, defining at least two runs associated via at least one rise, the rise being orthogonally related to the runs. Mass selective detectors are provided that can include at least a first pair of opposing electrodes with each of the opposing electrodes having a complimentary surface, in one cross section, defining at least two runs associated via a rise. Methods for optimizing mass separation within a mass selective detector are also provided, including providing mass separation parameters; providing one set electrodes within the separator having a surface operatively aligned within the separator, the surface, in one cross section, defining at least two runs associated via a rise, the rise being orthogonally related to the runs; and modifying one or both of the rise and/or runs to achieve the mass separation parameters. | 11-19-2015 |
20150332906 | SYSTEM AND METHOD FOR MALDI-TOF MASS SPECTROMETRY - A system and method for matrix assisted laser desorption time-of-flight (MALDI-TOF) mass spectrometry. A method for MALDI-TOF mass spectrometry includes initiating a spectral analysis of a sample on a MALDI-TOF spectrometer. The sample is ionized, and a first ion spectrum is detected and stored. Thereafter, the spectrometer is reset, and the ionizing, detecting, storing, and resetting are repeated until a predetermined plurality of spectra of the sample is acquired. | 11-19-2015 |
20150332907 | SAMPLE PREPARATION AND NANOELECTROSPRAY IONIZATION MASS SPECTROMETRY - Method for loading a sample of a target compound into a nanospray emitter tube for analysis by nanospray ionization mass spectrometry, wherein a cartridge having a fluid container, an inlet and an outlet is mounted onto a nanospray emitter tube on a nanospray emitter mount to form a nanospray emitter tube assembly, the assembly is mounted on a micro-centrifuge tube, a volume of the sample to be analyzed is loaded into the fluid container and the micro-centrifuge tube is spun on a centrifuge to transfer the sample into the nanospray emitter tube. | 11-19-2015 |
20150338354 | Remote Detection and Identification of Nuclear Materials Using Multiple Ion-Chambers - A system and method for detecting and identifying nuclear materials by detecting and measuring positive and negative ions in multiple ion chambers, wherein each ion chamber comprises a different gas, including oxygen, argon, nitrogen, carbon dioxide, and humid air, and one or more ion counters. The ion data can be transmitted to an isotope identification module. The ion data can include a distinctive pattern data of positive-ion production rates and negative-ion production rates generated from the measured positive and negative ions. The isotope identification module can compare the pattern data of positive-ion production rates and negative-ion production rates to an isotope data library, and identify a detected nuclear isotope with the isotope identification module. A display can show the identified detected nuclear isotope; a probability of the presence of the detected nuclear isotope; and a radioactivity of the detected nuclear isotope. | 11-26-2015 |
20150338374 | ION MOBILITY SPECTROMETER AND METHOD OF OPERATING SAME - In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a method of separating ions as a function of ion mobility includes repeatedly, and alternating between at least two different time durations, establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube at one or more frequencies which include one or more overtones of a fundamental frequency at which ions having the predefined mobility or range of mobilities are transmitted through the drift tube with the electric drift fields and electric repulsive fields repeatedly established with uniform time durations. | 11-26-2015 |
20150338413 | SYSTEM AND METHOD FOR ANALYSIS OF BIO-METABOLITES FOR-USE IN IMAGE-GUIDED SURGERY - A system for identifying a bio-marker using mass spectroscopy is provided that includes a sample receptacle configured to receive a tissue sample, a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data, and a computer system that includes a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions. The instructions cause the computer processor to: receive the mass spectrometry data from the mass spectrometry apparatus; analyze the mass spectrometry data to determine a presence of 2-Hydroxyglutarate (2-HG) in the tissue sample; and generate a report indicating a health of the tissue sample based on the presence of 2-HG in the tissue sample. | 11-26-2015 |
20150338426 | MASS SPECTROMETRIC DETERMINATION OF EICOSAPENTAENOIC ACID AND DOCOSAHEXAENOIC ACID - The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods. | 11-26-2015 |
20150340213 | Method and Apparatus for Mass Spectrometry of Macromolecular Complexes - A method of analyzing macromolecular complex ions, such protein complex ions, by mass spectrometry and apparatus for performing the method, wherein the method comprises: introducing macromolecular complex ions into a first fragmentation device and trapping the complex ions therein for a trapping period; fragmenting the trapped complex ions in the first fragmentation device to produce monomer subunit ions; optionally selecting one or more species of subunit ions by m/z; introducing one or more of the species of subunit ions into a second fragmentation device, spatially separated from the first fragmentation device; fragmenting the subunit ions in the second fragmentation device to produce a plurality of first fragment ions of the subunit ions; and mass analyzing the first fragment ions in a mass analyzer, or subjecting the first fragment ions to one or more further steps of fragmentation to form further fragment ions and mass analyzing the further fragment ions. | 11-26-2015 |
20150340214 | CHEMICAL SAMPLING AND DETECTION METHODS AND APPARATUS - This invention describes a sample collection and desorption device and method that collects residues of explosives and other chemicals from a surface and then introduces them into a detector. The desorption method and device include introducing additional chemicals while heating up the sample collector, thus, the collected sample may be converted via a chemical reaction or a catalytic process. The detector can be an ion mobility spectrometer or mass spectrometer. | 11-26-2015 |
20150340215 | Diathermy Knife Ionisation Source - A method of detecting one or more compounds, chemicals or contaminants in a substrate by mass spectrometry is disclosed. A non-living substrate is analysed by contacting the substrate with a diathermy knife. An electric current is applied to the diathermy knife such that the diathermy knife vaporises a portion of the substrate. The vapour is aspirated via a sampling tube pumped by a venturi pump into a vacuum chamber of a mass spectrometer. Analyte molecules are aspirated into the vacuum chamber whereupon they impact a surface of the vacuum chamber and are ionised to form analyte ions which are then mass analysed. | 11-26-2015 |
20150340216 | High Mass Accuracy Filtering for Improved Spectral Matching of High-Resolution Gas Chromatography-Mass Spectrometry Data Against Unit-Resolution Reference Databases - The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (MS) at high mass accuracy (such as ≦75 ppm or ≦30 ppm) and the obtained mass spectra are matched with one or more prospective candidate molecules or chemical formulas. The invention provide, for example, methods and systems wherein the possible fragments that can be generated from the candidate molecules or chemical formulas are determined as well as the masses of each of these fragments. The invention provide, for example, methods and systems wherein the high-resolution mass spectra are then compared with the calculated fragment masses for each of the candidate molecules or chemical formula, and the portion of the high-resolution mass spectra that corresponds or can be explained by the calculated fragment masses is determined. | 11-26-2015 |
20150340217 | Targeted Analysis for Tandem Mass Spectrometry - A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection TOF device that separates ions into packets in accordance with their m/z. A single pass ion page in the path of the precursor ions between the ion injector and the ion guide is controlled so that (only a subset of precursor ion packets, containing precursor ions of interest, is allowed onward transmission to the ion guide. A high resolution mass spectrometer is provided for analysis of those ions, or their fragments, which have been allowed passage through the ion gate. The technique permits multiple m/z ranges to be selected from a wise mass range of precursors, with optional fragmentation of one or more of the chosen ion species. | 11-26-2015 |
20150340220 | ION INJECTION FROM A QUADRUPOLE ION TRAP - A method of ejecting ions to be analysed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analysed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analysed from the quadrupole ion trap. | 11-26-2015 |
20150340221 | INSTRUMENTS FOR MEASURING ION SIZE DISTRIBUTION AND CONCENTRATION - Instruments are disclosed for analyzing ions from about 1000 to 10,000,000 Daltons by controlling a gaseous medium through which the ions travel under the influence of an electric field so that properties of the ions, such as diameter, electrical mobility, and charge, are measured. One embodiment of the disclosed instruments include an ion source, a nozzle, a jet relaxation region, an ion accumulation region, an electronic gate, a flow chamber and an ion detector. | 11-26-2015 |
20150346152 | MASS SPECTROMETRY SYSTEMS AND METHODS FOR ANALYSES ON LIPID AND OTHER IONS USING A UNIQUE WORKFLOW - The applicants' teachings provide in some aspects methods and apparatus for mass spectrometric analysis that identify the location of carbon-carbon double bonds, if any, in an analyte by (1) obtaining the m/z ratio of the intact analyte ions, (2) subjecting these ions to collision-induced dissociation and (3) determining relationships between masses and/or mass-to-charge ratios of the intact analyte ions and the fragments produced by such collision-induced dissociation. The methods and apparatus selectively subject analyte ions to ozone-induced dissociation based on those relationships and determine location(s) of carbon-carbon double bonds, if any, from reaction products of ozone-induced dissociation. | 12-03-2015 |
20150346183 | C PEPTIDE DETECTION BY MASS SPECTROMETRY - Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. The present invention provides methods for detecting the presence or amount of C peptide in a sample by mass spectrometry. | 12-03-2015 |
20150346186 | INTEGRATED DISEASE DIAGNOSTIC SYSTEM USING MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETER - A disease diagnostic system where a sample preparation unit and/or a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) data generation unit may be integrated in one system or a set of a system to improve the user-friendliness of the system. The system may include a sample preparation unit with processing modules and/or a handler to move samples in an autonomous manner to enhance reproducibility of measurement data and/or user-friendliness. A different set of processing modules may be selected for a particular disease type (e.g. such as cancer) to be diagnosed. The system may be used to identify biomaterials such as bacteria, virus, and fungi from body fluids like blood, urine, and saliva and other cells. | 12-03-2015 |
20150348767 | Imaging Mass Spectrometry Method and Device - A method of performing imaging mass spectrometry of a sample. The method comprises performing a first mass analysis of the sample using a first mass analyzer comprising a multi-pixel ion detector to obtain first mass spectral data representative of pixels of the sample. The method further comprises identifying clusters of pixels sharing one or more characteristics of first mass spectral data. The method also comprises performing a second mass analysis of the sample using a second mass analyzer to obtain second mass spectral data at at least one location in each cluster, wherein the number of locations is significantly less than the number of pixels in each cluster, said second mass analysis being of higher resolution than said first mass analysis. Also a mass spectrometry apparatus configured for carrying out the method. | 12-03-2015 |
20150348768 | COMBUSTION PRETREATMENT-ISOTOPE DILUTION MASS SPECTROMETRY - Provided is a combustion pretreatment-isotope dilution mass spectrometry measuring concentration of a target element for detection contained in a target sample for detection by using an isotope dilution mass spectrometry, including: pretreating the target sample for detection by combustion during an isotope dilution mass spectrometry, to thereby stabilize an isotope and further improve analysis ability, and therefore, the present invention is expected to be utilized as an element analysis method surpassing accuracy of the existing mass spectrometry method. | 12-03-2015 |
20150357173 | LASER ABLATION ATMOSPHERIC PRESSURE IONIZATION MASS SPECTROMETRY - In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material. An atmospheric pressure ionization source generates an ion population. The atmospheric pressure ionization source is operatively connected to the laser ablation chamber via a transfer line so that an ablated sample material is transportable thereto. A mass spectrometer is operatively connected to the laser ablation chamber and to the atmospheric pressure ionization source. The ablated sample material interacts with the atmospheric pressure ionization source to generate an ion population having a mass-to-charge ratio distribution. The ion population is transmitted to the mass spectrometer, which provides information on a mass-to-charge ratio distribution of the ion population. | 12-10-2015 |
20150364303 | Methods of operating a fourier transform mass analyzer - A method is disclosed for operating a mass spectrometer having a Fourier Transform (FT) analyzer, such as an orbital electrostatic trap mass analyzer, to avoid peak coalescence and/or other phenomena arising from frequency-shifting caused by ion-ion interactions. Ions of a first group are mass analyzed, for example in a quadrupole ion trap analyzer, to generate a mass spectrum. The estimated frequency shift of the characteristic periodic motion in the FT analyzer is calculated for one or more ion species of interest based on the intensities of adjacent (closely m/z-spaced) ion species. If the estimated frequency shift(s) for the one or more ion species exceeds a threshold, then a target ion population for an FT analyzer scan is adjusted downwardly to a value that produces a shift of acceptable value. An analytical scan of a second ion group is performed at the adjusted target ion population. | 12-17-2015 |
20150364304 | METHODS FOR ACQUIRING AND EVALUATING MASS SPECTRA IN FOURIER TRANSFORM MASS SPECTROMETERS - The invention provides a method for acquiring a mass spectrum with a Fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by Coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain. | 12-17-2015 |
20150364305 | DATA PROCESSING FOR MULTIPLEXED SPECTROMETRY - Multiplexed spectrometry, such as multiplexed ion mobility spectrometry (IMS), time-of-flight mass spectrometry (TOFMS), or hybrid IM-TOFMS, is carried out on a sample, and the resulting measurement data are deconvoluted. Noise may be removed from the measurement data prior to deconvolution. Alternatively or additionally, noise may be removed from the deconvoluted data. | 12-17-2015 |
20150364306 | CELLULAR PROBE DEVICE, SYSTEM AND ANALYSIS METHOD - A sampling probe, system and analysis method is disclosed. The sampling probe includes a tube having at least a first bore, a second bore, a first end, and a tapered second end; a first capillary partially disposed within the first bore, at least a portion of the first capillary extending from the first end of the tube; a second capillary partially disposed within the second bore, the second capillary having a portion with a free tapered end which extends from the first end of the tube; and wherein an end of the first capillary and an end of the second capillary converge at a junction in the tapered second end of the tube. | 12-17-2015 |
20150364308 | COLLISION CELL - A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. | 12-17-2015 |
20150364309 | RF Ion Guide with Axial Fields - RF ion guides are configured as an array of elongate electrodes arranged symmetrically about a central axis, to which RF voltages are applied. The RF electrodes include at least a portion of their length that is semi-transparent to electric fields. Auxiliary electrodes are then provided proximal to the RF electrodes distal to the ion guide axis, such that application of DC voltages to the auxiliary electrodes causes an auxiliary electric field to form between the auxiliary electrodes and the ion guide RF electrodes. A portion of this auxiliary electric field penetrates through the semi-transparent portions of the RF electrodes, such that the potentials within the ion guide are modified. The auxiliary electrode structures and voltages can be configured so that a potential gradient develops along the ion guide axis due to this field penetration, which provides an axial motive force for collision damped ions. | 12-17-2015 |
20150364310 | APPARATUS AND METHOD FOR GENERATING CHEMICAL SIGNATURES USING DIFFERENTIAL DESORPTION - The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes. | 12-17-2015 |
20150364312 | Systems and Methods Of Detecting and Demonstrating Heat Damage to Hair Via Evaluation of Peptides - A method to measure heat damage of keratin fibers comprising eluting a peptide from a hair sample with an aqueous solution; extracting the peptide using a suitable solvent sample; analyzing the peptide samples with MALDI-MS; resulting in peptide results; identifying presence of a marker peptide and identifying the m/z ratio for the peptide. | 12-17-2015 |
20150364315 | MASS SPECTROMETRY SYSTEMS WITH CONVECTIVE FLOW OF BUFFER GAS FOR ENHANCED SIGNALS AND RELATED METHODS - Mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where P | 12-17-2015 |
20150380230 | M/Z Targeted Attenuation on Time of Flight Instruments - A method of mass spectrometry is disclosed comprising separating ions according to one or more physico-chemical properties. Ions which are onwardly transmitted to a Time of Flight mass analyser are controlled by attenuating ions which would otherwise be transmitted to the Time of Flight mass analyser and cause saturation of an ion detector and which have been determined or which are predicted to have a relatively high intensity. | 12-31-2015 |
20150380231 | Improved Efficiency and Precise Control of Gas Phase Reactions in Mass Spectrometers Using an Auto Ejection Ion Trap - A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. The collision or reaction device further comprises a second device arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the first device without causing the first ions to be substantially ejected from the first device. | 12-31-2015 |
20150380232 | Device Allowing Improved Reaction Monitoring of Gas Phase Reactions in Mass Spectrometers Using an Auto Ejection Ion Trap - A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. A second device is arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the collision or reaction region. The collision or reaction device further comprises a device arranged and adapted to determine the time when the second ions and/or ions derived from the second ions are substantially ejected from the first device. | 12-31-2015 |
20150380233 | Ion Trap Mass Spectrometer - A novel MS-MS apparatus utilizing electrostatic traps is disclosed, along with an associated method of analysis. The apparatus may include a chromatograph, an ion source, a first mass spectrometer, a fragmentation cell, an ion guide, a pulsed converter, and a Z-directional elongated electrostatic trap. The electrostatic trap, which may be Z-elongated into a cylindrical electrostatic trap, includes at least one of an image current detector and a time-of-flight detector. The pulsed converter is Z-directionally elongated to match the electrostatic trap. Ion selection from electrostatic traps may be accomplished with an electrode that ejects ion from an oscillation space to a time-of-flight detector, a fragmentation surface, or a passage between E-trap regions. | 12-31-2015 |
20160003787 | Method and System for Monitoring Biomolecule Separations by Mass Spectrometry - Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column. Small samples are periodically taken from the first fluidic stream as it leaves the chromatography column and injected into a first branch of a second fluidic stream. Low molecular weight components detrimental to the efficient operation of the mass spectrometer are removed by an in-line dialysis cell. A second fraction of the second fluidic stream acts as the dialysate. In a second and preferred system provided in accordance with the present teaching, the first fraction of the second fluidic stream is further split downstream of the sampling mechanism through the use of a three-way connector. Approximately 0.3 to 5 microliters per minute continues through the dialysis cell and thereafter to the electrospray emitter of the mass spectrometer. | 01-07-2016 |
20160003800 | METHODS OF MONITORING FOR ADHERENCE TO ARIPIPRAZOLE THERAPY - Methods for helping to monitor subject adherence with a prescribed antipsychotic drug treatment regimen are disclosed. | 01-07-2016 |
20160005578 | PARALLEL ELEMENTAL AND MOLECULAR MASS SPECTROMETRY ANALYSIS WITH LASER ABLATION SAMPLING - An apparatus for mass spectrometry includes a laser ablation sampler comprising a laser ablation chamber and a laser which produces a laser beam. The laser irradiates and ablates a material from a sample placed within the laser ablation chamber so as to generate an ablated sample material. A transfer tube system comprising transfer tubes connect the laser ablation sample with, and provides a parallel and simultaneous transport of the ablated sample material to, each of a soft and a hard ionization source. The soft and hard ionization sources interact with the ablated sample material to respectively generate ion populations having a mass-to-charge ratio distribution. These respective mass-to-charge ratio distributions are respectively transmitted to a molecular mass spectrometer and to an elemental mass spectrometer which provide information on the mass-to-charge ratio distribution. The mass-to-charge ratio distributions are used to characterize a composition of the ablated sample material. | 01-07-2016 |
20160005581 | MULTIPLE ION GATE METHOD AND APPARATUS - A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum. | 01-07-2016 |
20160005582 | Ion Trap Mass Spectrometer - A mass spectrometer including an ion source, an ion guide, a pulsed converter, and an electrostatic analyzer is disclosed, along with a method of mass spectrometry and an ion injector. The ion source generates ions, such as ions within a continuous or a quasi-continuous ion beam. The ion guide receives a portion of the ions generated by the ion source. The pulsed converter, which receives ions from the ion guide, includes at least one electrode connected to a RF signal. The pulsed converter may include a means for ejecting the ions in the form of ion packets. The electrostatic analyzer forms a two-dimensional electrostatic field in an X-Y plane. The electrostatic field is substantially extended in a Z-direction that is locally orthogonal to the X-Y plane and may be curved or linear. Ions undergo isochronous ion oscillations in the electrostatic field. The pulsed converter and electrostatic analyzer are Z-directionally elongated. | 01-07-2016 |
20160005587 | Ion Trap Mass Spectrometer - An electrostatic analyzer including at least one first set of electrodes, at least one second set of electrodes, and a field free space separating the two sets of electrodes is disclosed. The two sets of electrodes form two-dimensional electrostatic fields of ion mirrors and are arranged to provide isochronous ion oscillations in an x-y plane. Both sets of electrodes are curves at a constant curvature radius R along a third locally orthogonal Z-direction to form a torroidal field region. A related method is also disclosed. | 01-07-2016 |
20160011205 | MASS SPECTROMETRY METHOD USING MATRIX | 01-14-2016 |
20160013039 | Spatially Correlated Dynamic Focusing | 01-14-2016 |
20160013040 | Ion Trap Mass Spectrometer | 01-14-2016 |
20160018410 | Deep MALDI TOF Mass Spectrometry of Complex Biological Samples, e.g., Serum, and Uses Thereof - A method of analyzing a biological sample, for example serum or other blood-based samples, using a MALDI-TOF mass spectrometer instrument is described. The method includes the steps of applying the sample to a sample spot on a MALDI-TOF sample plate and directing more than 20,000 laser shots to the sample at the sample spot and collecting mass-spectral data from the instrument. In some embodiments at least 100,000 laser shots and even 500,000 shots are directed onto the sample. It has been discovered that this approach, referred to as “deep-MALDI”, leads to a reduction in the noise level in the mass spectra and that a significant amount of additional spectral information can be obtained from the sample. Moreover, peaks visible at lower number of shots become better defined and allow for more reliable comparisons between samples. | 01-21-2016 |
20160020076 | Collision Cell for Tandem Mass Spectrometry - A method and apparatus for tandem mass spectrometry is disclosed. Precursor ions are fragmented and the fragments are accumulated in parallel, by converting an incoming stream of ions from an ion source ( | 01-21-2016 |
20160020079 | Charging Plate for Enhancing Multiply Charged Ions by Laser Desorption - A sample plate | 01-21-2016 |
20160020080 | SAMPLE PLATE FOR MALDI-TOF MASS SPECTROMETER AND METHOD OF MANUFACTURING THE SAMPLE PLATE AND MASS SPECTROMETRY METHOD USING THE SAMPLE PLATE - The present invention relates to a sample plate to be used for a MALDI-TOF (Matrix Assisted Laser Desorption Ionization Time of Flight) mass spectrometer, and more particularly, to a sample plate for a MALDI-TOF mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a MALDI-TOF mass spectrometer so as to overcome the limits of the gas chromatography method of the related art. According to the present invention, there is provided a sample plate including a target plate, an organic matrix formed on one surface of the target plate, a parylene thin film formed on the target plate having the organic matrix formed thereon and formed to cover the entire organic matrix, and a sample fixing layer formed on the parylene thin film. The sample fixing layer is made of at least one material selected from a group consisting of graphene and carbon nano tube (CNT). | 01-21-2016 |
20160020081 | Method to Perform Beam-Type Collision-Activated Dissociation in the Pre-Existing Ion Injection Pathway of a Mass Spectrometer - Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dissociation methods. The methods can be practiced using a wide range of mass spectrometer configurations and allows MS | 01-21-2016 |
20160020082 | MASS SPECTROMETER SYSTEM AND METHOD - An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit | 01-21-2016 |
20160027607 | INDUCTIVELY-COUPLED PLASMA ION SOURCE FOR USE WITH A FOCUSED ION BEAM COLUMN WITH SELECTABLE IONS - An inductively coupled plasma source having multiple gases in the plasma chamber provides multiple ion species to a focusing column. A mass filter allows for selection of a specific ion species and rapid changing from one species to another. | 01-28-2016 |
20160027625 | Automated Tuning for MALDI Ion Imaging - A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionisation device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionisation device. A second portion of the sample is then analysed using the one or more optimum or preferred parameters. | 01-28-2016 |
20160027626 | Data Directed Storage of Imaging Mass Spectra - A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired. | 01-28-2016 |
20160027627 | Time Shift for Improved Ion Mobility Spectrometry or Separation Digitisation - A method of analysing ions is disclosed comprising: (i) separating ions according to a physico-chemical property in a separator; (ii) transmitting ions which emerge from the separator through a transfer device with a first transit time t1, energising a pusher electrode or orthogonal acceleration electrode and obtaining first data; (iii) transmitting ions which subsequently emerge from the separator through the transfer device with a second greater transit time t2, energising the pusher electrode or orthogonal acceleration electrode and obtaining second data; and (iv) repeating steps (ii) and (iii) one or more times. The pusher electrode or orthogonal acceleration electrode is energised with a period t3, wherein t2-t1 is arranged to equal t3/2. The first and second data are combined to form a composite data set. | 01-28-2016 |
20160027628 | Improved Method of Data Dependent Control - A method of mass spectrometry is disclosed comprising obtaining first data at a first time and/or location and second data at a second subsequent time and/or location. A future trend or rate of change in the data is predicted from the first and second data. An attenuation factor of an attenuation device is adjusted in response to the predicted future trend or rate of change in the data so as to maintain operation of a detector or detector system within the dynamic range of the detector or detector system and/or to prevent saturation of the detector or detector system. | 01-28-2016 |
20160027629 | APPARATUS FOR ELEMENTAL ANALYSIS OF PARTICLES BY MASS SPECTROMETRY - A mass spectrometer has a particle introduction system and a vaporizer, atomizer, and ionizer configured to produce ions from elements associated with the particle. An ion mass-to-charge ratio analyzer is configured to separate ions according to their mass-to-charge ratio. A detector is positioned to detect at least some of the separated ions. A digital processor is configured to: (a) acquire data from the detector including at least first data in a primary detection group defined to comprise one or more mass-to-charge ratio channels of the mass spectrometer; (b) determine whether or not ions detected during at least one sampling cycle meet at least one selection criterion indicating a presence of a particle in the mass spectrometer; and (c) determine whether or not to use data in a secondary detection group based on whether or not the at least one selection criterion is met. | 01-28-2016 |
20160027632 | Toroidal Trapping Geometry Pulsed Ion Source - An ion trap is disclosed comprising: a plurality of electrodes which define a toroidal or annular ion confining volume that extends around a central axis; a first device arranged and adapted to apply one or more DC voltages to said plurality of electrodes in order to generate a DC potential well which acts to confine ions in a radial direction within said toroidal or annular ion confining volume, wherein said radial direction is substantially perpendicular to said central axis; and a control system arranged and adapted to non-mass selectively eject ions from said toroidal or annular ion confining volume. The ion trap enables a large number of ions to be trapped and ejected simultaneously. | 01-28-2016 |
20160033456 | Gaseous Mercury Detection Systems, Calibration Systems, and Related Methods - Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air. For example, the gaseous mercury detection systems collect gas-phase mercury-compounds from ambient air and release the gas-phase mercury-compounds at concentrations capable of being measured by a gas-chromatography mass spectrometer without heating the gas-phase mercury-compounds above a decomposition temperature of at least one gaseous mercury compound that may present in the mercury-containing gas. The calibration systems are configured to determine an accuracy of or calibrate a gaseous mercury detection system. The disclosed calibration systems may be integrated with or distinct from the gaseous mercury detection systems disclosed herein. | 02-04-2016 |
20160035548 | A DDA Experiment with Reduced Data Processing - A method of mass spectrometry is disclosed comprising: | 02-04-2016 |
20160035549 | Hybrid Mass Spectrometer and Methods of Operating a Mass Spectrometer - A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list. The method enables more efficient utilization of analyzer time. | 02-04-2016 |
20160035550 | PLASMA CLEANING FOR MASS SPECTROMETERS - A mass spectrometry (MS) system may be cleaned by generating plasma and contacting an internal surface of the system to be cleaned with the plasma. The system may be switched between operating in an analytical mode and in a cleaning mode. In the analytical mode a sample is analyzed, and plasma may or may not be actively generated. In the cleaning mode the plasma is actively generated, and the sample may or may not be analyzed. | 02-04-2016 |
20160035551 | Data Dependent Control of the Intensity of Ions Separated in Multiple Dimensions - A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined. If it is determined that the most intense ion peak would cause saturation of an ion detector or ion detection system then the method further comprises adjusting the attenuation factor of the attenuation device to a second value and obtaining mass spectral data wherein the adjustment of the attenuation factor substantially alters the intensity of all ions which are detected by the ion detector or ion detection system equally and irrespective of the mass to charge ratio of the ions. The intensity of the mass spectral data is then scaled based upon the degree to which the attenuation factor of the attenuation device was increased or reduced. | 02-04-2016 |
20160035552 | Method and System for Tandem Mass Spectrometry - A method of data independent MS-MS analysis is disclosed. The method comprises ramping or stepping in small steps of a wide (at least 10 amu) parent mass window in a first parent selecting mass spectrometer (MS1), arranging rapid ion transfer through a collisional cell, either by axial gas flow or by an axial DC field or by a travelling RF wave, frequently pulsing an orthogonal accelerator with a string of time-encoded pulses, analyzing fragment ions in a multi-reflecting time-flight mass spectrometer, acquiring data in a data logging format, and decoding signal strings corresponding to the entire scan of parent masses, such that fragment spectra are formed based on time correlation between fragment and parent masses. Frequent pulsing is expected to recover parent and fragment time correlation with an accuracy of approximately 1 Th, in spite of using much wider mass window in the first MS. | 02-04-2016 |
20160035554 | Aperture Gas Flow Restriction - A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture. The effective area of the opening between the two vacuum chambers may be varied by rotating a disk having an aperture in front of the differential pumping aperture so as to vary the gas flow rate through the opening and between the two chambers. | 02-04-2016 |
20160035555 | ION TRAP MASS ANALYZER APPARATUS, METHODS, AND SYSTEMS UTILIZING ONE OR MORE MULTIPLE POTENTIAL ION GUIDE (MPIG) ELECTRODES - In one aspect of the invention, an ion trap mass analyzer includes a variable- or multi-potential type ion guide (MPIG) assembly which has been pre-configured to produce a parabolic-type potential field. Each MPIG electrode has a resistive coating of designed characteristics. In one example the coating varies in thickness along the length of an underlying uniform substrate. The MPIG assembly can be a single MPIG electrode or an array of a plurality of MPIG electrodes. An array can facilitate delocalization for improved performance. This chemical modification of a uniform underlying substrate promotes cheaper and flexible instruments. The modified MPIG electrodes also allow miniaturization (e.g. micro and perhaps even nano-scale), which allows miniaturization of the instrument in which the single or plural modified MPIG electrode(s) are placed. This promotes portability and field use instead of limitation to laboratory settings. | 02-04-2016 |
20160042932 | PELTIER-COOLED CRYOGENIC LASER ABLATION CELL - Peltier-cooled cryogenic laser ablation cells for sample preparation. | 02-11-2016 |
20160042933 | Removal of Ions from Survey Scans Using Variable Window Band-Pass Filtering to Improve Intrascan Dynamic Range - Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows. | 02-11-2016 |
20160049282 | Data Directed Acquisition of Imaging Mass - A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location. A determination is then made as to whether or not the first mass spectral data satisfies a condition, wherein if it is determined that the first mass spectral data does satisfy the condition then the method further comprises: (i) switching to acquire second mass spectral data related to a second pixel location which is substantially adjacent to the first pixel location so that the second mass spectral data is acquired at a second resolution which is higher than the first resolution; and (ii) determining whether or not the second mass spectral data satisfies the condition, wherein if it is determined that the second mass spectral data does satisfy the condition then the method further comprises acquiring third mass spectral data related to a third pixel location which is substantially adjacent to the first or second pixel locations so that the third mass spectral is acquired at the second resolution and wherein if it is determined that the second or third mass spectral data does not satisfy the condition then the method further comprises switching back to scanning the sample at the first resolution. | 02-18-2016 |
20160049286 | ABRIDGED ION TRAP - TIME OF FLIGHT MASS SPECTROMETER - An improved trap-TOF mass spectrometer has a set of electrodes arranged to produce both a quadrupolar RF confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the RF field and then, at a selected time, the RF confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a TOF MS analysis. The apparatus of the present invention may be used alone or in conjunction with other analyzers to produce mass spectra from analyte ions. | 02-18-2016 |
20160052942 | TRIFLUOROBORATE MASS SPECTROMETRIC TAGS - The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as mass tags for use in negative ion mode. When subject to MS fragmentation, organo-trifluoroborates preferentially undergo neutral losses of hydrogen fluoride (HF) or boron trifluoride (BF | 02-25-2016 |
20160054263 | ION MODIFICATION - An ion mobility spectrometry method comprising determining whether a sample comprises ions having a first characteristic, and in the event that it is determined that the sample comprises ions having the first characteristic, applying thermal energy together with a radio frequency, RF, electric field to parent ions so as to obtain daughter ions having a second characteristic for inferring at least one identity for the parent ions based on the first characteristic and the second characteristic. | 02-25-2016 |
20160054264 | A Method of Screening Samples - A method of screening a sample for at least one compound of interest is disclosed. The method comprises comparing the ion mobility and at least one further physicochemical property of the ions of a compound of interest to the same properties of candidate ions in the sample. The properties of the compound of interest are matched to those of a candidate ion in the sample then the sample may be determined to comprise the compound of interest. | 02-25-2016 |
20160054293 | Prenatal Screening - The present invention relates to a method for screening maternal urine samples for changes in the pattern of mass spectral fingerprinting which have been found to be characteristic of fetal aneuploidies such as Down's Syndrome and have application for the screening of other fetal abnormalities and disorders of pregnancy including gestational trophoblastic diseases. | 02-25-2016 |
20160056027 | QUANTITATIVE ANALYSIS METHOD USING MASS SPECTROMETRY WHEREIN LASER PULSE ENERGY IS ADJUSTED - A quantitative analysis method using MALDI mass spectrometry wherein laser pulse energy is adjusted is disclosed. More particularly, a method for measuring the equilibrium constant of a proton exchange reaction between a matrix and a sample at a constant temperature, by dividing an ion signal ratio by a value (concentration ratio) obtained by dividing the concentration of the sample by the concentration of the matrix, may include (i) obtaining MALDI mass spectra having constant TICs by adjusting the intensity of energy applied to a specimen having a predetermined amount of a matrix and a predetermined amount of a sample mixed therein and (ii) measuring the MALDI mass spectra obtained in step (i) for a value (ion signal ratio) obtained by dividing sample ion signal strength by matrix ion signal strength. | 02-25-2016 |
20160056029 | Apparatus and Methods for an Atmospheric Sampling Inlet for a Portable Mass Spectrometer - Atmospheric sampling system designed to minimize cross-contamination between successive samples acquired by a portable, or handheld, mass spectrometer. Techniques to reduce the overall sample load on portable mass spectrometers having limited pumping capacity, such as capture pumps. Techniques and methods employing simple manual devices and micro vacuum pumps for purging the inlet system of a mass spectrometer. Reduction of cross-contamination between successive samples, permitting a portable mass spectrometer to correctly associate sample positives with specific sample sites or individuals. | 02-25-2016 |
20160056030 | SYSTEM AND METHOD OF DELICATE MEMBRANE CONDENSED PHASE MEMBRANE INTRODUCTION MASS SPECTROMETRY (CP-MIMS) - Systems and methods for analyzing a sample comprising an analyte selected from a volatile organic compound, a semi-volatile organic compound, a non-volatile organic compound, a polar organic compound and a halogenated non-volatile organic compound are provided. The systems comprises an ionization source, a flow cell or an immersion probe with a delicate membrane, the flow cell or immersion probe for accepting the sample, and the delicate membrane interface in fluid communication with the ionization source and a mass spectrometer. The flow cell system further comprises a simultaneously matched pumping in and out delivery (SMPIOD) system for delivering an acceptor phase comprising the analyte from the delicate membrane interface to the mass spectrometer at a constant acceptor flow pressure and a constant acceptor flow rate. | 02-25-2016 |
20160056031 | SAMPLE ANALYSIS FOR MASS CYTOMETRY - The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry. | 02-25-2016 |
20160061850 | MASS SPECTROMETRIC QUANTITATION FOR METABOLITES OF LEFLUNOMIDE - Methods are described for determining the amount of metabolites of leflunomide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying teriflunomide in a sample. | 03-03-2016 |
20160064202 | MALDI-TOF MASS SPECTROMETERS WITH DELAY TIME VARIATIONS AND RELATED METHODS - MALDI-TOF MS systems have solid state lasers and successive and varied delay times between ionization and acceleration (e.g. extraction) to change focus masses during a single sample signal acquisition without requiring tuning of the MS by a user. The (successive) different delay times can change by 1 ns to about 500 ns, and can be in a range that is between 1-2500 nanoseconds. | 03-03-2016 |
20160071709 | Apparatus and Methods for Controlling Miniaturized Arrays of Ion Traps - Apparatus and methods for controlling miniaturized arrays of ion traps, including cylindrical ion traps, rectilinear ion traps, and linear ion traps. Improved methods for applying supplemental AC signals to individual ion traps in an ion trap array. Methods of organizing ion trap arrays and operating the arrays in a manner to improve sensitivity, resolution and mass accuracy. Techniques for performing simultaneous detection of multiple compounds from ion trap arrays. Optimization of ion trap performance by dynamic optimization or adjustment of RF trapping frequency and voltage amplitude. | 03-10-2016 |
20160071710 | MASS SPECTROMETRY WITH SELECTIVE ION FILTRATION BY DIGITAL THRESHOLDING - The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process. | 03-10-2016 |
20160071711 | IMAGING MASS SPECTROMETRIC DATA PROCESSING METHOD AND IMAGING MASS SPECTROMETER - Compressed data of mass spectra obtained at respective measurement points and normalization coefficients for XIC normalization or the like are stored in a memory ( | 03-10-2016 |
20160071713 | ION IMPLANTATION SYSTEM AND PROCESS FOR ULTRASENSITIVE DETERMINATION OF TARGET ISOTOPES - A system and process are disclosed for ultrasensitive determination of target isotopes of analytical interest in a sample. Target isotopes may be implanted in an implant area on a high-purity substrate to pre-concentrate the target isotopes free of contaminants. A known quantity of a tracer isotope may also be implanted. Target isotopes and tracer isotopes may be determined in a mass spectrometer. The present invention provides ultrasensitive determination of target isotopes in the sample. | 03-10-2016 |
20160071717 | ORTHOGONAL ACCELERATION SYSTEM FOR TIME-OF-FLIGHT MASS SPECTROMETER - An orthogonal pulse accelerator for a Time-of-Flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension. The first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates, and the orthogonal pulse accelerator directs ions in the ion beam through the apertures. | 03-10-2016 |
20160077054 | Improved Ion Mobility Spectrometer - A method of analysing ions by ion mobility separation is disclosed. The method comprises controlling the amount of charge within an ion trap and then pulsing the ions from the ion trap into an ion mobility separator. This enables the charge injected into the ion mobility separator to be controlled and hence prevents space-charge interactions between the ions from distorting the ion mobility peaks detected by the detector. | 03-17-2016 |
20160079046 | MULTIPLE FREQUENCY RF AMPLIFIER, MASS SPECTROMETER INCLUDING THE SAME, AND MASS SPECTROMETRY METHOD OF MASS SPECTROMETER - Provided is a multiple frequency Radio Frequency (RF) amplifier. The multiple frequency RF amplifier includes a waveform generation circuit configured to generate an RF signal by amplitude and frequency-modulating a reference waveform signal, a drive amplifier circuit configured to drive-amplify the RF signal, and a power amplifier circuit configured to generate a multiple frequency RF voltage signal through a power amplification of the drive-amplified RF signal and output the multiple frequency RF voltage signal to an ion trap for a mass spectrometry. | 03-17-2016 |
20160079047 | Systems and Methods for Using Variable Mass Selection Window Widths in Tandem Mass Spectrometry - Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample. | 03-17-2016 |
20160079048 | Systems and Methods for Rapidly Screening Samples by Mass Spectrometry - Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans. | 03-17-2016 |
20160079049 | METHODS FOR DETECTING REVERSE TRIIODOTHYRONINE BY MASS SPECTROMETRY - Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample. | 03-17-2016 |
20160079050 | MASS SPECTROMETRY METHOD, ION GENERATOR AND MASS SPECTROMETRY SYSTEM - A mass spectrometry method includes a step of atomizing liquid including a sample using an ultrasonic transducer; a step of transferring the atomized liquid; a step of generating ions from the transferred liquid using a DART ion source; and a step of analyzing a mass spectrometry by introducing the generated ions into a mass spectrometer. | 03-17-2016 |
20160079052 | Method and Apparatus for Mass Spectrometry - A method for analysing ions according to their mass-to-charge ratio and mass spectrometer for performing the method, comprising directing a collimated ion beam along an ion path from an ion source to an ion detector, causing a portion of the ion beam to contact one or more surfaces prior to reaching the ion detector, wherein the method comprises providing a coating on and/or heating the one or more surfaces to reduce variation in their surface patch potentials. The method is applicable to multi-reflection time-of-flight (MR TOF) mass spectrometry. | 03-17-2016 |
20160086780 | MULTI-SEGMENT INJECTION-CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY (MSI-CE-MS): A MULTIPLEXED SCREENING PLATFORM AND DATA WORKFLOW FOR CHEMICAL ANALYSIS - Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer. The incorporation of a quality control/reference sample and the use of dilution patterning with specific injection configurations also enables encoding of information temporally for enhanced data processing with quality assurance. | 03-24-2016 |
20160086782 | Species Detection Using Mass Spectrometry - Systems and methods are provided for species detection using mass spectrometry. In various embodiments, a multiple reaction monitoring (MRM) experiment is performed on a sample targeting one or more peptide transitions that are unique to one or more species using a tandem mass spectrometer. One or more measured product ion spectra are received from the tandem mass spectrometer using the processor. The one or more measured product ion spectra are compared to product ions of the one or more peptide transitions that are unique to one or more species using the processor. One or more species of the sample are detected by reporting product ions of the one or more peptide transitions that are unique to one or more species that match the one or more measured product ion spectra using the processor. | 03-24-2016 |
20160086783 | Improved Data Quality after Demultiplexing of Overlapped Acquisition Windows - Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample. A first precursor mass window and the corresponding first product ion spectrum are selected from a plurality of overlapping stepped precursor mass windows and their corresponding product ion spectra. A product ion spectrum is demultiplexed for each overlapped portion of the first precursor mass window producing two or more demultiplexed first product ion spectra for the first precursor mass window. The two or more demultiplexed first product ion spectra are added together producing a reconstructed summed demultiplexed first product ion spectrum. Missing product ions are identified in the summed demultiplexed first product ion spectrum by comparing the summed demultiplexed first product ion spectrum and the first product ion spectrum. | 03-24-2016 |
20160086785 | METHODS AND DEVICES FOR GENERATING DOUBLE EMULSIONS - The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis. | 03-24-2016 |
20160086787 | DETECTION OF IONS IN AN ION TRAP - An ion trap such as an ion cyclotron resonance analyzer cell (trap) is described wherein the ion trap comprises a plurality of electrodes and has at least one integrated ion detector, preferably a position-sensitive and/or time-sensitive ion detector, wherein at least part of said ion detector is configured as an electrode of said ion trap. Methods of position-sensitive detection of ions in such ion trap are described as well. | 03-24-2016 |
20160091481 | METHODS AND SYSTEMS FOR DETERMINING AUTISM SPECTRUM DISORDER RISK - In certain embodiments, the invention stems from the discovery that analysis of population distribution curves of metabolite levels in blood can be used to facilitate predicting risk of autism spectrum disorder (ASD) and/or to differentiate between ASD and non-ASD developmental delay (DD) in a subject. In certain aspects, information from assessment of the presence, absence, and/or direction (upper or lower) of a tail effect in a metabolite distribution curve is utilized to predict risk of ASD and/or to differentiate between ASD and DD. | 03-31-2016 |
20160093479 | Compact Mass Spectrometer - A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P | 03-31-2016 |
20160093480 | Compact Mass Spectrometer - A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide is located within the first vacuum chamber. An ion detector is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a split flow turbomolecular vacuum pump comprising an intermediate or interstage port connected to the second vacuum chamber and a high vacuum (“HV”) port connected to the third vacuum chamber. The first vacuum pump is also arranged and adapted to act as a backing vacuum pump to the split flow turbomolecular vacuum pump. The first vacuum pump has a maximum pumping speed ≦10 m | 03-31-2016 |
20160093481 | Investigating Chemical-Based Events that Occur in Vehicles - A method and apparatus for investigating a chemical-based event inside a vehicle without significant delay. A number of samples of air are collected at a number of locations inside the vehicle in response to a detection of the chemical-based event inside the vehicle. A number of chemical profiles for the number of samples are generated on-site using a portable chemical profiling device. A probable cause of the chemical-based event is identified using at least one of the number of chemical profiles. | 03-31-2016 |
20160093482 | Modulation of Instrument Resolution Dependant upon the Complexity of a Previous Scan - Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample. | 03-31-2016 |
20160097749 | ANALYTE MASS SPECTROMETRY QUANTITATION USING A UNIVERSAL REPORTER - Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter. | 04-07-2016 |
20160098514 | Predictive Test for Aggressiveness or Indolence of Prostate Cancer from Mass Spectrometry of Blood-Based Sample - A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described. | 04-07-2016 |
20160099136 | Systems and Methods for Acquiring Data for Mass Spectrometry Images - Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample. A mass range is divided into two or more mass window widths. For each location of the two or more locations, the tandem mass spectrometer is instructed to fragment the plurality of ions received for each location using each mass window width of the two or more mass window widths and to analyze resulting product ions. A product ion spectrum is produced for each mass window width, and a plurality of product ion spectra are produced for each location of the two or more locations. | 04-07-2016 |
20160104611 | Space Focus Time of Flight Mass Spectrometer - A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times AT of ions arriving at the ion detector. | 04-14-2016 |
20160111266 | Compact Mass Spectrometer - A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The product of the pressure P | 04-21-2016 |
20160111267 | Ion Detection System and Method - A detection system and a method for detecting ions which have been separated in a time-of-flight (TOF) mass analyzer, comprising an amplifying arrangement for converting ions into packets of secondary particles and amplifying the packets of secondary particles, wherein the amplifying arrangement is arranged so that each packet of secondary particles produces at least a first output and a second output separated in time and so that during the delay between producing the first and second output the first output produced by a packet of secondary particles is used for modulating the second output produced by the same packet. An increased dynamic range of detection and protection of the detection system against intense ion pulses is thereby provided. | 04-21-2016 |
20160111270 | GLOW DISCHARGE MASS SPECTROMETRY METHOD AND DEVICE - A glow discharge mass spectrometry device and method, the device including a glow discharge lamp ( | 04-21-2016 |
20160111271 | TIME-OF-FLIGHT MASS SPECTROMETER WITH SPATIAL FOCUSING OF A BROAD MASS RANGE - The invention relates to time-of-flight mass spectrometers which operate with pulsed ionization of superficially adsorbed analyte substances and with an improvement in the mass resolution by means of a time-delayed start of the ion acceleration; in particular with ion-accelerating voltages which change over time after a delayed start in order to obtain a constant mass resolution over broad mass ranges. Since the varying acceleration produces a broadening of the ion beam at right angles to the direction of flight, and this broadening increases with the ion mass, the invention proposes to compensate, to the desired extent, for the broadening of the ion beam with the aid of an additional ion-optical lens whose voltage is also varied over time. The invention also relates to measurement methods therefor. | 04-21-2016 |
20160118234 | Contamination Filter for Mass Spectrometer - Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss. | 04-28-2016 |
20160118238 | Compact Mass Spectrometer - A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure <10 mbar. A first RF ion guide is located within the first vacuum chamber and an ion detector is located in the third vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. A split flow turbomolecular vacuum pump comprising an intermediate or interstage port is connected to the second vacuum chamber and a high vacuum (“HV”) port is connected to the third vacuum chamber. The first vacuum pump is also arranged and adapted to act as a backing vacuum pump to the split flow turbomolecular vacuum pump and the first vacuum pump has a maximum pumping speed ≦10 m | 04-28-2016 |
20160123936 | Versatile Ambient Ionization-Based Interface for LC/MS - An apparatus ( | 05-05-2016 |
20160126073 | PATHOLOGY INTERFACE SYSTEM FOR MASS SPECTROMETRY - A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display. | 05-05-2016 |
20160126074 | Method of Calibrating Ion Signals - A method of mass or ion mobility spectrometry is disclosed comprising: providing an ion source for generating analyte ions and reference ions; providing a mass analyser or ion mobility separator (IMS); providing an ion trap between the ion source and the mass analyser or IMS; guiding reference ions from the ion source into the ion trap and trapping the reference ions in the ion trap; guiding the analyte ions from the ion source into the mass analyser or IMS, wherein the analyte ions bypass the ion trap; and releasing reference ions from the ion trap into the mass analyser or IMS for analysis. | 05-05-2016 |
20160126075 | MASS SPECTROMETRY METHOD FOR MEASURING VITAMIN B6 IN BODY FLUIDS - Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography. | 05-05-2016 |
20160126078 | INTEGRATED MASS SPECTROMETRY SYSTEMS - The disclosure features mass spectrometry systems that include: an ion source; a module featuring an ion trap, an ion detector, and a module housing that at least partially surrounds the ion trap and the ion detector; and a vacuum pump featuring a housing having a recess dimensioned to receive the module, so that when the module is positioned within the recess of the vacuum pump housing, a portion of the module is surrounded by the vacuum pump housing, and during operation of the system, the ion source, ion trap, ion detector, and vacuum pump are connected along a common gas flow path and heat is transferred from the vacuum pump to the module. | 05-05-2016 |
20160126083 | Method of Generating Electric Field for Manipulating Charged Particles - A device for manipulating charged particles using an axial electric field as they travel along a longitudinal axis of the device is disclosed. The method comprises providing an outer electrode for generating an electric field and providing a plurality of inner electrodes that are separated by gaps of different lengths. The electric field generated by the outer electrode penetrates the gaps between the inner electrodes and the gaps are selected such that the desired potential profile is arranged along the longitudinal axis in order to manipulate the charged particles in the desired manner. | 05-05-2016 |
20160131620 | ENHANCED SENSITIVITY OF DETECTION IN ELECTROSPRAY IONIZATION MASS SPECTROMETRY USING A POST-COLUMN MODIFIER AND A MICROFLUIDIC DEVICE - A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample. | 05-12-2016 |
20160131621 | ION GENERATION USING MODIFIED WETTED POROUS MATERIALS - The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate. | 05-12-2016 |
20160133450 | Intelligent Dynamic Range Enhancement - A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers from saturation or is approaching saturation then the method further comprises automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data. The method further comprises substituting one or more portions of the first mass spectral data with one or more corresponding portions of the second mass spectral data multiplied or scaled by an attenuation or scale factor and/or by an integer or other value so as to form a composite mass spectrum, wherein the composite mass spectrum comprises one or more ion peaks from the first mass spectral data and one or more ion peaks from the second mass spectral data. | 05-12-2016 |
20160141162 | PROJECTION-TYPE CHARGED PARTICLE OPTICAL SYSTEM AND IMAGING MASS SPECTROMETRY APPARATUS - Provided is a projection-type charged particle optical system in which a projection magnification can be changed while a decrease in the accuracy in measuring a mass-to-charge ratio is being suppressed. A projection-type charged particle optical system according to the present invention includes a first electrode disposed so as to face a sample and having an opening formed therein for allowing a charged particle to pass, a second electrode disposed on a side of the first electrode opposite to where the sample is disposed and having an opening formed therein for allowing the charged particle to pass, and a flight-tube electrode disposed such that the charged particle that has been emitted from the sample and has passed through the second electrode enters the flight-tube electrode and being configured to form a substantially equipotential space thereinside. A principal plane is formed at at least two positions in a travel path of the charged particle. | 05-19-2016 |
20160141163 | MASS SPECTROMETRIC DEVICE AND MASS SPECTROMETRIC DEVICE CONTROL METHOD - This mass spectrometric device is provided with a sample container ( | 05-19-2016 |
20160141165 | SYSTEM AND METHOD OF DETECTION AND QUANTIFICATION BY MASS SPECTROMETRY AND BY ACTIVATING IONISED MOLECULAR SPECIES - Disclosed is a system and method of mass spectrometry, including: a. ionising an analyte to form a precursor ion (A) having a mass-to-charge ratio (m/z), in which m represents the mass and z the electric charge number; b. activating the precursor ion (A) by interaction with a beam of neutral species, ions, electrons or photons, having an energy chosen on the basis of the physicochemical properties of the precursor ion, the activation being suitable for producing a product ion (B, C) having the same mass m as the precursor ion (A) and an electric charge number z′ such that z′ is a non-zero integer different from z; c. separating the product ion (B, C, E, F) having a predefined mass-to-charge ratio (m/z′); d. detecting the product ion (B, C) having the predefined mass-to-charge ratio (m/z′). | 05-19-2016 |
20160141167 | Collision Cell - A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. | 05-19-2016 |
20160146716 | METHOD AND DEVICE FOR MEASURING PERMEATION BY MASS SPECTROMETRY - The invention relates to a method for measuring permeation of gases through a material comprising the following steps:
| 05-26-2016 |
20160148792 | Mass Spectrometer With Bypass of a Fragmentation Device - A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer. | 05-26-2016 |
20160148793 | METHOD FOR OBTAINING MASS SPECTRUM OF IONS GENERATED AT CONSTANT TEMPERATURE BY MEASURING TOTAL ION COUNT, AND USE OF MATRIX FOR QUANTITATIVE ANALYSIS USING MALDI MASS SPECTROMETRY - A method for obtaining a mass spectrum of reproducible ions generated at a constant temperature by measuring a total ion count, and the use of a matrix for quantitative analysis using MALDI mass spectrometry are disclosed. More particularly, a method for measuring a mass spectrum of ions generated at a constant temperature may include selecting only mass spectra having the same total ion count, among multiple mass spectra obtained from ions formed by applying energy to a specimen having a sample mixed therein. | 05-26-2016 |
20160153943 | MONOLITHIC COLUMN CHROMATOGRAPHY | 06-02-2016 |
20160155620 | Imaging Mass Spectrometry Method and Device | 06-02-2016 |
20160160641 | ON-SITE MASS SPECTROMETRY FOR LIQUID AND EXTRACTED GAS ANALYSIS OF DRILLING FLUIDS - An example method for analyzing drilling fluid used in a drilling operation within a subterranean formation may include receiving a drilling fluid sample from a flow of drilling fluid at a surface of the subterranean formation. A chemical composition of the drilling fluid sample may be determined using a mass spectrometer. A formation characteristic of the subterranean formation may be determined using the determined chemical composition. Determining the chemical composition of the drilling fluid sample may include determining the chemical composition of at least one of extracted gas from the drilling fluid sample and a liquid portion of the drilling fluid sample. | 06-09-2016 |
20160161460 | MICROALGAL FLOUR COMPOSITIONS OF OPTIMISED SENSORY QUALITY - Thus, the present invention relates to a method for determining the organoleptic quality of a microalgal flour composition, comprising determining the total content of 13 volatile organic compounds, the 13 volatile organic compounds being heptanal, 3-octen-2-one, 2,4-heptadienal, 3,5-octadien-2-one, 2,4-nonadienal, 2,4-decadienal, hexanoic acid, 2-ethylhexanoic acid, heptanoic acid, myristate-1, laurate-1, myristate-2 and geranyl acetone. | 06-09-2016 |
20160163522 | Early detection of hepatocellular carcinoma in high risk populations using MALDI-TOF Mass Spectrometry - Hepatocellular carcinoma (HCC) is detected in a patient with liver disease. Mass spectrometry data from a blood-based sample from the patient is compared to a reference set of mass-spectrometry data from a multitude of other patients with liver disease, including patients with and without HCC, in a general purpose computer configured as a classifier. The classifier generates a class label, such as HCC or No HCC, for the test sample. A laboratory system for early detection of HCC in patients with liver disease is also disclosed. Alternative testing strategies using AFP measurement and a reference set for classification in the form of class-labeled mass spectral data from blood-based samples of lung cancer patients are also described, including multi-stage testing. | 06-09-2016 |
20160163524 | ZERO VOLTAGE MASS SPECTROMETRY PROBES AND SYSTEMS - The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer. | 06-09-2016 |
20160163530 | SYSTEMS FOR SEPARATING IONS AND NEUTRALS AND METHODS OF OPERATING THE SAME - A mass spectrometer system includes a pulsed ion source configured to generate ionized molecules and neutral molecules. The system also includes a first enclosure coupled in flow communication with the pulsed ion source. The first enclosure defines a first vacuum chamber and an ion inlet aperture. The system further includes a detector positioned within said first enclosure and a plurality of ion transmission devices positioned within the first vacuum chamber and aligned with the ion inlet aperture. The plurality of ion transmission devices is configured to channel and accelerate ionized molecules through a first transmission path such that the ionized molecules and the neutral molecules are physically separated in space and temporally separated. | 06-09-2016 |
20160169837 | Mass spectrometer | 06-16-2016 |
20160172146 | ION SOURCE FOR SOFT ELECTRON IONIZATION AND RELATED SYSTEMS AND METHODS | 06-16-2016 |
20160172170 | ANALYZER | 06-16-2016 |
20160172173 | Cascaded-Signal-Intensifier-Based Ion Imaging Detector for Mass Spectrometer | 06-16-2016 |
20160172176 | SYSTEMS AND METHODS OF SUPPRESSING UNWANTED IONS | 06-16-2016 |
20160172180 | METHODS, APPARATUS, AND SYSTEM FOR MASS SPECTROMETRY | 06-16-2016 |
20160181075 | Two-Dimensional Separation and Imaging Technique for the Rapid Analysis of Biological Samples | 06-23-2016 |
20160181077 | SAMPLE QUANTITATION WITH A MINIATURE MASS SPECTROMETER | 06-23-2016 |
20160181079 | MASS SPECTROMETER INLET WITH REDUCED AVERAGE FLOW | 06-23-2016 |
20160181083 | ICR Cell Operating with a Duplexer | 06-23-2016 |
20160181084 | Varying Frequency during a Quadrupole Scan for Improved Resolution and Mass Range | 06-23-2016 |
20160187296 | Ion Mobility Method and Apparatus - A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers. | 06-30-2016 |
20160187297 | METHOD AND PORTABLE ION MOBILITY SPECTROMETER FOR THE DETECTION OF AN AEROSOL - A portable ion mobility spectrometry apparatus ( | 06-30-2016 |
20160189912 | Combined Electrostatic Lens System for Ion Implantation - A system and method are provided for implanting ions at low energies into a workpiece. An ion source configured to generate an ion beam is provided, wherein a mass resolving magnet is configured to mass resolve the ion beam. The ion beam may be a ribbon beam or a scanned spot ion beam. A mass resolving aperture positioned downstream of the mass resolving magnet filters undesirable species from the ion beam. A combined electrostatic lens system is positioned downstream of the mass analyzer, wherein a path of the ion beam is deflected and contaminants are generally filtered out of the ion beam, while concurrently decelerating and parallelizing the ion beam. A workpiece scanning system is further positioned downstream of the combined electrostatic lens system, and is configured to selectively translate a workpiece in one or more directions through the ion beam, therein implanting ions into the workpiece. | 06-30-2016 |
20160189944 | METHOD FOR ANALYSIS OF SAMPLE AND APPARATUS THEREFOR - A thermal analysis step, a molecule ionization step and a molecular structure analysis step are executed in parallel to a temperature increasing step. In the molecule ionization step, component molecules contained in gas evolved from a sample S due to temperature increase are ionized, and in the molecular structure analysis step, any selected ion out of molecular ions obtained in the molecule ionization step is dissociated to generate fragment ions corresponding to the structural factors of the molecule, and the structure of the molecule is analyzed on the basis of the fragment ions. | 06-30-2016 |
20160195510 | METHODS FOR DETERMINATION OF TOTAL HOMOCYSTEINE | 07-07-2016 |
20160196964 | AC GATE ION FILTER METHOD AND APPARATUS | 07-07-2016 |
20160202211 | Hybrid Ion Mobility Spectrometer | 07-14-2016 |
20160203962 | HIGH DUTY CYCLE ION SPECTROMETER | 07-14-2016 |
20160203967 | ION MODIFICATION | 07-14-2016 |
20160254129 | Data Dependent MS/MS Analysis | 09-01-2016 |
20160254130 | MS/MS Analysis Using ECD or ETD Fragmentation | 09-01-2016 |
20160254133 | AMBIENT DESORPTION, IONIZATION, AND EXCITATION FOR SPECTROMETRY | 09-01-2016 |
20160375713 | FINGERPRINT LIFTING SYSTEMS AND METHODS FOR BIOMETRICS AND CHEMICAL ANALYSIS - Fingerprint lifting systems and related methods are described which enable the collected print(s) to be subjected to analytical techniques that employ relatively high temperatures. The fingerprint lifting systems include a thin layer of a heat resistant pressure sensitive adhesive. | 12-29-2016 |
20160379810 | Systems and Methods for Acquiring Data for Mass Spectrometry Images - Systems and methods are provided for maximizing the data acquired from a sample in a mass spectrometry imaging experiment. An ion source device is instructed to produce and transmit to a tandem mass spectrometer a plurality of ions for each location of two or more locations of a sample. A mass range is divided into two or more mass window widths. For each location of the two or more locations, the tandem mass spectrometer is instructed to fragment the plurality of ions received for each location using each mass window width of the two or more mass window widths and to analyze resulting product ions. A product ion spectrum is produced for each mass window width, and a plurality of product ion spectra are produced for each location of the two or more locations. | 12-29-2016 |
20160379813 | Systems and Methods for Using Interleaving Window Widths in Tandem Mass Spectrometry - Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width. | 12-29-2016 |
20170236700 | Time of Flight Mass Spectrometer | 08-17-2017 |
20180024099 | Mass Spectrometric Detection and Analysis Method | 01-25-2018 |
20180024108 | SYSTEMS AND METHODS FOR SCREENING A SAMPLE BASED ON MULTIPLE REACTION MONITORING MASS SPECTROMETRY | 01-25-2018 |
20180024123 | Cationic Tags for Attomole Level Detection of Analytes by Mass Spectrometry | 01-25-2018 |
20180024151 | MASS SPECTROMETRIC DETERMINATION OF EICOSAPENTAENOIC ACID AND DOCOSAHEXAENOIC ACID | 01-25-2018 |
20180025898 | Time-of-Flight Analysis of a Continuous Beam of Ions by a Detector Array | 01-25-2018 |
20190145983 | ANALYSIS OF AMINO ACIDS IN BODY FLUID BY LIQUID CHROMOTOGRAPHY-MASS SPECTROMETRY | 05-16-2019 |
20220134343 | SAMPLE TRANSPORT APPARATUS FOR MASS SPECTROMETRY - Systems and methods are provided for high-efficiency transport of single particles for inductively coupled plasma mass spectrometry. Single particles may be delivered to the mass spectrometer for quantification of trace elements. The systems may include droplet generation, conveyance module, capillary tubing, and/or an integrated inductively coupled plasma (ICP) torch, which may allow for the sequential transportation of single particles. | 05-05-2022 |
20220136999 | METHOD AND APPARATUS FOR ION MOBILITY SEPARATIONS UTILIZING ALTERNATING CURRENT WAVEFORMS - Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180° to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1°-359° to move ions longitudinally through the apparatus for separation. | 05-05-2022 |