Entries |
Document | Title | Date |
20080197065 | Sintered polymeric materials and applications thereof - The present invention provides sintered polymeric materials and methods of making the same which are useful in a variety of applications. In one embodiment, the present invention provides a sintered polymeric material comprising at least one plastic and at least one elastomer. | 08-21-2008 |
20080210614 | SEPARATION DEVICES AND METHOD FOR SEPARATING PHOSPHORYLATED PEPTIDES AND PROTEINS - Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms. | 09-04-2008 |
20080210615 | Hydrophilic Crosslinked Polymer - The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerisation from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers. | 09-04-2008 |
20080210616 | Flash chromatography cartridge - A low pressure liquid chromatographic cartridge is provided having a tubular polymer container adapted to receive a chromatographic packing material. The container has an outlet port located at a downstream end of the container and container threads formed on an upstream end of the container. A polymer cap having cap threads located on the cap threadingly engage the container threads. An inlet port is located on an upstream end of the cap. A resilient fluid tight seal is interposed between the polymer cap and container suitable for use in low pressure liquid chromatography. A locking tab on a skirt of the cap engages a recess on the container when the seal engages the cap and container to lock the cap in position relative to the container. | 09-04-2008 |
20080217232 | PROCESS AND DEVICE FOR SIMULATED MOVING BED SEPARATION WITH A REDUCED NUMBER OF LARGE DIAMETER VALVES AND A REDUCED LINE VOLUME - The invention concerns a simulated moving bed adsorption separation device comprising a limited number of large diameter valves. According to the invention, the device comprises a column with a plurality of sectors Sk with 2 superimposed plates Pi with a single distribution network, each sector Sk comprising an external principal bypass line Lk connected to each plate Pi of Sk via a large diameter plate valve Vi and an external secondary bypass line Mk comprising a small diameter valve VMk connected to the adjacent sector Sk−1. Each line Lk comprises a flow rate limitation means and is connected to each fluid network via a single large diameter valve. Further, the connectors of lines Lk onto the column are offset by at most 20° inside Sk to limit the volume of lines Lk, and are offset by a mean angle in the range 70° to 110° between two neighbouring sectors Sk and Sk+1 so as not to weaken the column mechanically. The plates preferably comprise panels DMEi,j with parallel segments the direction of which varies from plate to plate or per group of 2 plates. | 09-11-2008 |
20080245715 | LIQUID CHROMATOGRAPH - A liquid chromatograph having a flow passage switching mechanism for switching among a normal analysis flow passage formed by connecting a mobile-phase-sending-unit, a second mixer having a large capacity, a sample injection portion, an analysis column and a detector in this order, a concentration flow passage formed by connecting a concentration liquid sending unit for sending a liquid for transferring a sample to be concentrated, the second mixer, the sample injection portion and a trapping column in this order, and a concentration analysis flow passage formed by connecting the mobile-phase-sending-unit, a first mixer having a smaller capacity than the second mixer, the trapping column, the analysis column and the detector in this order so that any one of the three flow passages is selectively formed, The mobile-phase-sending-unit is set so that the flow rate of a mobile phase becomes smaller when the concentration analysis flow passage is selected than when the normal analysis flow passage is selected. | 10-09-2008 |
20080245716 | Separation column and liquid chromatography system with this column - A monolithic separation column and a liquid chromatography system using the same are provided by which the pressure tightness is improved, and the manufacturing is enabled at a low temperature, thus preventing the degradation of the separation performance. A monolithic rod | 10-09-2008 |
20080257811 | Method of separation of polymers - A method of using electrokinetics for separating particles in a buffer solution is provided, where a chromatographic column is provided having a non-uniform internal longitudinal cross-section. At least one main inlet for inputting solution and at least one main outlet for outputting solution are provided. At least one sample inlet and at least one sample outlet are provided. The particle is introduced to the column from the sample inlet and fractionated samples are eluted from the sample outlet, where quality control and further analysis are enabled. An electric field is applied to the solution in the column to generate a charged double layer at a solid-liquid interface within the column. The electric filed moves ions within the double layer, and a non-uniform velocity profile is induced to the buffer solution. The moving ions carry the particles along the column and the particles are separated according to size or charge. | 10-23-2008 |
20080264848 | Mobile phase dilution scheme for enhanced chromatography - A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a sample. A sample is injected into the strong mobile phase, and subsequently diluted with a weak mobile phase. The resulting sample-containing weak mobile phase is passed through a chromatography column for retention and separation of the components of the sample. | 10-30-2008 |
20080272042 | Chromatography Columns and Their Operation - A chromatography column ( | 11-06-2008 |
20080272043 | REVERSED ENDCAPPING AND BONDING OF CHROMATOGRAPHIC STATIONARY PHASES USING HYDROSILANES - A process for producing a chromatographic stationary phase for use in reversed-phase chromatography. Chromatographic stationary phases prepared according to the methods of the current invention and liquid chromatography columns, which include the stationary phases, are also provided. | 11-06-2008 |
20080272044 | Interphase Injector Device For the Direct Coupling of Liquid Chromatography and Gas Chromatography - The invention relates to an interface injector device for the direct coupling of liquid chromatography and gas chromatography, comprising an outer body ( | 11-06-2008 |
20080272045 | AUTOMATED PACKING SYSTEM AND METHOD FOR CHROMATOGRAPHY COLUMNS - A column packing system comprises a control unit provided with software for calculating the breakpoint where a movable adapter comes into contact with a settled bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the movable adapter has to move into the column in order to achieve a desired amount of bed compression. | 11-06-2008 |
20080283458 | Separation column and liquid chromatography apparatus using the same - Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block. | 11-20-2008 |
20080290016 | SUPPORTING STRUCTURES FOR PREPARATIVE CHROMATOGRAPHY COLUMNS - The plunger used as the upper enclosure in a preparative chromatography column is suspended by one or more rods that are supported by a frame through coupling connections on the frame that can fix the position of the rod(s) relative to the frame, while the position of the rod(s) is controlled by a motorized drive system that is suspended above the column. The drive system is mounted either to the column lid or to a functional plate positioned a short distance above the column lid. These constructions allow the plunger to be raised and lowered so that the column and its parts can be exchanged, all without the need for a hoist or crane. | 11-27-2008 |
20080314812 | Apparatus and Methods for Cooling Samples - Embodiments of the present invention are directed to apparatus and methods for performing separations of compounds held in a solution. Embodiments of the present invention allow detectors to operate at constant reproducible temperatures that are lower than the temperature of fluids exiting separation devices. An apparatus of the present invention has pump means, fluid conveying means, sample injection means, separation means and heat dissipation means. The heat dissipation means is in fluid communication with the separation means for receiving the fluid and removing thermal energy. | 12-25-2008 |
20090001007 | SEPARATION COLUMN FOR LIQUID CHROMATOGRAPH APPARATUS AND LIQUID CHROMATOGRAPH APPARATUS USING THEREOF - Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using thereof are to be provided. | 01-01-2009 |
20090001008 | End-Cap Device For High Efficiency Disposable Chromatography Column - A low cost re-usable end-cap for disposable chromatographic columns or solid phase extraction cartridges that simultaneously provide sealing of the column and axial compression, and chromatography columns and solid phase extraction cartridges employing such re-usable end caps. | 01-01-2009 |
20090014373 | Magazine for Separation Columns - A separation unit comprising a magazine unit with a magazine is described. The magazine comprises a plurality of pockets, each pocket being adapted for accommodating a separation column for separating compounds of a fluid sample. The magazine unit is adapted for moving any of the pockets to a structural component, wherein a pocket and the structural component are adapted for complementing one another to form a column compartment. | 01-15-2009 |
20090026122 | BIOCOMPATIBLE SOLID-PHASE MICROEXTRACTION COATINGS AND METHODS FOR THEIR PREPARATION - A biocompatible coating for solid phase microextraction (SPME) of a small molecule from a biological matrix. The coating comprises SPME particles and a biocompatible polymer. The biocompatible polymer (e.g. polyacrylonitrile) reduces adsorption of proteins or macromolecules onto the SPME particles and allows the SPME particles to extract the small molecule from the matrix. A process for coating a flexible fiber with a biocompatible coating. The process comprises: coating the fiber with a suspension of SPME particles, the SPME particles being suspended in a solution of a biocompatible polymer and a solvent, the biocompatible polymer can comprise polyacrylonitrile (PAN); drying the coated fiber to remove the solvent; and curing the dried coated fiber at an elevated temperature. | 01-29-2009 |
20090045119 | POROUS POLYMER AND PROCESS FOR PRODUCING THE SAME - The present invention relates to a polymeric porous material characterized in that: the porous material has a bimodal pore size distribution attributable to macropores having a pore size of at least 50 nm and mesopores having a pore size of from 2 nm to less than 50 nm, the proportion of the specific surface area of the macropores to the specific surface area of all pores of the porous material is at least 10%, and the porous material is produced by (1) polymerizing a monomer in the presence of a polymerization initiator using as a porogen a solution obtained by dissolving a polymer having a weight-average molecular weight of at least 100,000 and a molecular weight distribution Mw/Mn of not more than 1.5 in a good solvent for the monomer, and (2) removing the porogen from the resultant product. | 02-19-2009 |
20090065415 | Chromatography column - Disclosed is a chromatographic column for use with chromatographic materials packed in a defined manner. | 03-12-2009 |
20090065416 | ELASTIC POROUS COLUMN MATERIAL - A packing composition ( | 03-12-2009 |
20090071888 | FILTER SYSTEM - A chromatography column to bind molecules or proteins, is filled with a replaceable matrix and is provided with fill elements with which a single feed tube can be connected to an across the column distributed fill element. The fill element keeps an inner land area free from fill openings which can be closed. With the fill element it is possible to dispense the matrix into the column in an equally spread manner. Elements are present to internally flush the feed tube, while there are features to make the flushing impossible during filling with matrix. | 03-19-2009 |
20090078633 | CHROMATOGRAPHIC STATIONARY PHASES - A chromatographic stationary phase for use in reversed-phase chromatography. A process for producing a chromatographic stationary phase for use in reversed-phase chromatography, chromatographic stationary phases prepared according to the methods of the current invention, and liquid chromatography columns, which include the stationary phases, are also provided. | 03-26-2009 |
20090078634 | Chromatography columns - The present invention relates to a chromatography column that removes the longitudinal load from the column tube altogether and transfers it to a yoke and stanchion arrangement situated around but external to the column tube. By using the yoke/stanchion system, the central adjuster can be used to move the top end into and out of the housing. Thus, when internal pressure is applied to the column, the tube experiences no longitudinal load. Additionally, the yoke and stanchion design allows for complete removal of the end from the tube without cumbersome disassembly. Moreover, the yoke provides a place to retain the end while the tube is being filled, emptied, cleaned or repaired. | 03-26-2009 |
20090095668 | PREPARATION OF MONOLITHIC ARTICLES - The present invention relates to a method of producing a polymeric monolithic article by radical polymerization, which method comprises providing a mold comprising a solution of radically polymerisable monomers; a transition metal catalyst and a complexing ligand in a solvent; adding an ATRP initiator and, optionally, flushing the mixture with an inert gas; carrying out radical polymerisation in the mold; optionally, removing the monolithic article obtained in from the mold; and washing the monolithic article obtained as described above. | 04-16-2009 |
20090127177 | POROUS INORGANIC/ORGANIC HYBRID PARTICLES FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR THEIR PREPARATION - Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and that offer more efficient chromatographic separations than that known in the art. | 05-21-2009 |
20090173680 | CONTINUOUS COUNTERCURRENT CHROMATOGRAPHY SYSTEM - A continuous countercurrent chromatography system has several rotating chambers arranged around a rotational axis. The chambers are provided for receiving a liquid or liquid mixture to be examined, and the individual chambers are interconnected via liquid carrying connections in such a way as to relay two liquids in countercurrent, wherein one liquid first passes through several chambers and is then returned to the chambers first traversed. | 07-09-2009 |
20090178966 | Process for Producing Organic Porous Material and Organic Porous Column and Organic Porous Material - An organic porous material is provided being excellent in mechanical properties such as strength and in which structures of a skeleton and pores are controlled more precisely. By a production process including (i) subjecting a low molecular compound having living radical and/or anionic polymerizability to living radical or anionic polymerization in a system including the compound, an organic polymer as a phase separation inducing component, a polymerization initiator, and a polymerization solvent, and thereby forming a gel including a skeletal phase rich in a polymer of the compound and a solvent phase rich in the solvent and having a co-continuous structure formed of the skeletal and solvent phases, and (ii) removing the solvent from the gel thus formed to form a skeleton containing the polymer as a base material thereof from the skeletal phase while forming first pores from the solvent phase, and thereby obtaining an organic porous material with a co-continuous structure formed of the skeleton and the first pores. | 07-16-2009 |
20090184039 | MONOLITHIC COLUMN - Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes. | 07-23-2009 |
20090188852 | REVERSED ENDCAPPING AND BONDING OF CHROMATOGRAPHIC STATIONARY PHASES USING HYDROSILANES - A process for producing a chromatographic stationary phase for use in reversed-phase chromatography. Chromatographic stationary phases prepared according to the methods of the current invention and liquid chromatography columns, which include the stationary phases, are also provided. | 07-30-2009 |
20090188853 | CHROMATOGRAPHY COLUMN DISTRIBUTION SYSTEM - A chromatography column distribution system ( | 07-30-2009 |
20090218267 | SEPARATION COLUMN AND LIQUID CHROMATOGRAPH - The present invention provides a separation column including a monolithic rod without a resin coating material. The separation column can prevent the monolithic rod from destroying, and a liquid can be delivered at a high pressure into the separation column. The separation column includes the monolithic rod (monolithic silica rod) in a tapered-columnar shape, and a clad with the interior formed in a tapered-columnar shape. The monolithic rod is built into the clad. | 09-03-2009 |
20090230045 | Column and cartridge column using the same | 09-17-2009 |
20090294344 | Fluid mixer assembly - Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly includes, inter alia, a housing, an inlet fitting, and a mixer cartridge assembly. The housing has a fluid receiving section and a fluid discharge section with a fluid outlet formed therein. A central bore extends between the fluid receiving section and fluid discharge section. An inlet fitting is engaged with the housing and has first and second fluid inlet ports formed therein that extend from the fitting exterior to the fluid receiving section of the housing. A mixer cartridge assembly is disposed within the central bore of the housing and is positioned between the inlet fitting and the downstream end portion of the housing. The mixer cartridge assembly includes a body portion, a plurality of spheres disposed within a central mixing chamber formed in the body portion, and mechanism for retaining the spheres in the mixing chamber. | 12-03-2009 |
20100000927 | Fluid Conduits With Molded Plastic Part - A method of providing a conduit ( | 01-07-2010 |
20100000928 | CHROMATOGRAPHY COLUMNS AND THEIR OPERAITON - A method of operating chromatography column apparatus comprising a column tube ( | 01-07-2010 |
20100012565 | High Efficiency Chromatography Column with Re-usable End Cap - A low cost re-usable end-cap for disposable chromatographic columns or solid phase extraction cartridges that simultaneously provide sealing of the column and axial compression, and chromatography columns and solid phase extraction cartridges employing such re-usable end caps. | 01-21-2010 |
20100012566 | SEPARATION COLUMN AND LIQUID CHROMOTOGRAPH USING THE SAME - The flow rate of a solvent is reduced as a separation column and the separation performance is improved even under high-pressure conditions. There is provided a separation column including a monolith rod into which a sample and a mobile phase flow, the separation column comprising: a coating material coated on the outer circumference of a monolith rod; a support member into which the monolith rod coated with the coating material is inserted, and a rod fixing material fitted into or filled a gap between the coating material and the support member; wherein the upper end face of the rod fixing material is sealed, the upper end face being the inflow-side end when the separation column is assembled. | 01-21-2010 |
20100032357 | CHROMATOGRAPHY COLUMN AND MANUFACTURING METHOD OF THE SAME - A high separation efficiency column | 02-11-2010 |
20100038297 | Poly (Vinyl Alcohol) Polymers, Uses and Preparation Thereof - There are provided poly(vinyl alcohol) polymers and copolymers containing vinyl alcohol or vinyl acetate and derivatives thereof such as poly(ethylene glycol)-grafted poly(vinyl alcohol) polymers or polyether-grafted poly(vinyl alcohol) polymers. These polymers can contain various functional groups. Such polymers can be use as polymer matrix or solid support for various chemical substrates such as organic substrates and reagents. Cross-linked poly(vinyl alcohol) polymers and copolymers are also provided. Methods for preparing such polymers as well as several of their uses are also included. | 02-18-2010 |
20100038298 | HIGH-PERFORMANCE CHROMATOGRAPHIC COLUMNS CONTAINING ORGANIC OR COMPOSITE POLYMERIC MONOLITHIC SUPPORTS AND METHOD FOR THEIR PREPARATION - The invention concerns high-performance chromatographic columns containing polymeric monolithic supports with continuous bimodal porosity, suitable for the separation and/or purification of organic compounds of low, medium and high molecular weight, and bio-organic compounds such as peptides, proteins, oligo- and polynucleotides, oligo- and polysaccharides. The proposed columns include a hollow tubular support made of silica-based amorphous material or internally lined with such material, containing a monolithic stationary phase having a continuous, porous and rigid polymeric structure, wherein such stationary phase covalently bonds onto the internal walls of the said hollow tubular support. The chromatographic efficiency of the column is greater than 50,000 plates per metre. The invention also concerns methods for preparing such monolithic columns with gamma radiation-induced polymerization processes. | 02-18-2010 |
20100038299 | METHOD OF SUBSTANCE SEPARATION BY SUPERCRITICAL FLUID CHROMATOGRAPHY AND VAPOR LIQUID SEPARATOR FOR USE THEREIN - A method comprising liquefying a gas to thereby obtain a liquefied gas; injecting a sample into a mobile phase containing a solvent and a supercritical fluid formed from the liquefied gas; passing this mobile phase through a column so that the mobile phase containing desired substance is divided into the solvent and the gas; and separating the desired substance from the solvent, wherein when the pressure of the gas divided from the mobile phase is higher than the pressure of the gas fed for formation of the liquefied gas from gas supply device, the gas divided from the mobile phase is liquefied. Further, there is provided a vapor liquid separator for use in the method. | 02-18-2010 |
20100072122 | Supporting plate of a device - A supporting plate of a device is suggested. The device has at least one component and a housing for at least partly protecting the component. The supporting plate has at least one receiving element adapted for accepting the at least one component of the device in at least one of the following manners: in a form-closed manner, in a force-closed manner. The supporting plate is part of the housing. | 03-25-2010 |
20100084327 | RECOVERY AND PRECIPITATION OF VARIOUS ELEMENTS AND COMPOUNDS - Systems and methods are disclosed for extracting a plurality of materials from a solution. These include a plurality of extraction devices. The extraction devices use a resin suspended above at least one screen, and the resin is used to extract at least one material from a fluid. A liquid is forced through the plurality of extraction devices and a separate material is extracted in each of the extraction devices. The resin is selected for each of the extraction devices and is based upon the material for which that extraction device is designed to remove from the fluid. Each of the extraction devices operate in series to remove at least one material from the fluid. | 04-08-2010 |
20100084328 | PREPARATION OF POLYSACCHARIDE BEADS - The present invention relates a method of preparing agarose beads, which method results in a population of beads which are of relatively uniform particle size. In an advantageous embodiment, the beads are of a particle size less than 10 μm, and the coefficient of variation C.V. of the population is less than 15%. The beads according to the invention are advantageously used in biological separation methods, such as in the production of chromatographic packing materials; drug carriers; or in any method of biological engineering. | 04-08-2010 |
20100126921 | MULTIPLE SEGMENT CHROMATOGRAPHY ASSEMBLY FOR PACKING A CHROMATOGRAPHY COLUMN - A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and fit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use. | 05-27-2010 |
20100133160 | ADSORBING PATHOGEN-INACTIVATING COMPOUNDS WITH POROUS PARTICLES IMMOBILIZED IN A MATRIX - Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 μm to about 1500 μm. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product. | 06-03-2010 |
20100133161 | Metal-Coated Superficially Porous Supports as a Medium for HPLC of Phosphorus-Containing Materials - Methods for the separation of biological materials from a sample mixture using a superficially porous particle coated (or clad) with a metal are provided herein. Methods using the support as a chromatographic column are also provided. | 06-03-2010 |
20100140154 | GROUP IV METAL OXIDE MONOLITHIC COLUMNS - The present invention discloses methods of preparing a continuous, porous metal oxide monolith in a container. The method involves providing a reaction mixture containing a metal salt or metal alkoxide compound, a solvent, and a porogenic reagent. Next, an epoxide is added to the reaction mixture under conditions effective to initiate condensation and polymerization of the reaction mixture. Then, a container is filled with the reaction mixture after epoxide addition to obtain a continuous, porous metal oxide monolith in the container. The present invention also discloses columns including a tubular container and a continuous, porous Group IV metal oxide monolith in contact with the inner walls of the tubular container, where the Group IV metal oxide monolith is free of any support or matrix material, and other articles including a continuous, porous Group IV metal oxide monolith, where the metal oxide monolith is free of any support or matrix material. | 06-10-2010 |
20100147758 | TENSION-FORCE COUPLED HIGH-PRESSURE PUMPING - A pumping apparatus ( | 06-17-2010 |
20100176043 | MOBILE PHASE DILUTION SCHEME FOR ENHANCED CHROMATOGRAPHY - A method and device for increasing the loading capacity of a chromatography column through dilution of a mobile phase at the head of the column. A strong mobile phase is provided for dissolving a sample. A sample is injected into the strong mobile phase, and subsequently diluted with a weak mobile phase. The resulting sample-containing weak mobile phase is passed through a chromatography column for retention and separation of the components of the sample. | 07-15-2010 |
20100181239 | Integrated High Throughput System for the Analysis of Biomolecules - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 07-22-2010 |
20100181240 | HPLC COLUMN - A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use. | 07-22-2010 |
20100181241 | CHROMATOGRAPHY COLUMN AND METHOD OF MAINTENANCE - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 07-22-2010 |
20100200488 | CELLS AND CONNECTING CHANNELS FOR CENTRIFUGAL PARTITION CHROMATOGRAPHY DEVICES - The present invention relates to cells ( | 08-12-2010 |
20100213112 | ELEMENTS FOR SEPARATING SUBSTANCES BY DISTRIBUTING BETWEEN A STATIONARY AND A MOBILE PHASE, AND METHOD FOR THE PRODUCTION OF A SEPARATING DEVICE, - The invention relates to elements for separating substances by distributing between a stationary and a mobile phase. Said separating elements comprise any stationary phase and a support element. The separating elements are part of a set that is provided with at least two separating elements T | 08-26-2010 |
20100219115 | SYSTEM AND METHOD FOR ASSEMBLING A LARGE SCALE CHROMATOGRAPHY STRUCTURE - A container system is disclosed, where the container system includes a housing. A chromatography cartridge is disposed in the housing. A structural support in the housing is configured to retain the chromatography cartridge within the housing. The housing is configured to withstand a certain amount of pressure generated inside the chromatography cartridge. The chromatography cartridge is disposed in the housing either in horizontal or in vertical position. | 09-02-2010 |
20100224543 | Connection assembly for ultra high pressure liquid chromatography - A fitting assembly having a double-headed ferrule, a nut, and a fitting that may be assemble or dissembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end have an internally tapered portion adapted to receive the first end of a ferrule, and further includes a fitting with a first end having an internally tapered portion adapted to receive the second end of the ferrule and a second end adapted to be removably connected to a component or fitting of a liquid chromatography system. The nut, ferrule and fitting of the fitting assembly have passageways therethrough for receiving and removably holding tubing. | 09-09-2010 |
20100224544 | PRODUCTION PROCESS OF FILM AND COLUMN FOR CATION CHROMATOGRAPHY - One object of the present invention is to produce a weakly acidic cation exchanger under mild conditions. Another object of the present invention is to produce a more firm weakly acidic cation exchange film. Still another object of the present invention is to provide a weakly acidic cation exchanger capable of realizing high-level separation of monovalent cation and simultaneously analyzing monovalent cation and divalent cation and also provide a chromatography column using the ion exchanger. In the production method of a weakly acidic cation exchanger of the invention, a solvent incapable of dissolving a polymer having a double bond within the molecule is used and the weakly acidic cation exchanger is produced by polymerization at temperature of 100° C. or less. | 09-09-2010 |
20100230339 | Particulate chiral separation material - A chiral particulate material and method of making the same are provided. The material includes a fibrous protein or chiral synthetic polymer, optionally crosslinked, organized into a multilayered chiral structure including nanoscale chiral pores or channels. The particles are useful for performing chiral separations, including in chromatographic applications. | 09-16-2010 |
20100230340 | SEALING ASSEMBLY FOR A CHROMATOGRAPHY COLUMN - The present invention relates to a sealing assembly for use in chromatography columns and methods for forming a seal in such columns. The assembly comprises a sealing element composed of a material having a low coefficient of friction and a separate resilient member co-operating therewith. The seal provided is stable over a temperature range of +2° C. to +30° C. | 09-16-2010 |
20100230341 | APPARATUS FOR THE SEMI-CONTINUOUS CHROMATOGRAPHIC SEPARATION OF BINARY AND MULTI-COMPONENT MIXTURES - The invention relates to a semi-continuous chromatographic method for the separation of binary and multi-component mixtures and corresponding devices. | 09-16-2010 |
20100276350 | PREPARATIVE SEPARATION/PURIFICATION SYSTEM - A mixed liquid passage ( | 11-04-2010 |
20100276351 | APPARATUS FOR COUNTERCURRENT CHROMATOGRAPHY - A plate apparatus for use in countercurrent chromatography is disclosed which comprises a disk shaped tube support ( | 11-04-2010 |
20100320132 | SUPPRESSOR UTILIZING MICRO ION EXCHANGE TUBE AND ION CHROMATOGRAPH UTILIZING THE SAME - Disclosed herein is a suppressor using one ion-exchange tube which has an inner diameter close to that of a tube connected to a separation column and which is constituted by an ion-exchange membrane. The ion-exchange tube is folded or wound more than once in a plane into a sheet form to provide an ion-exchange tube sheet through which an eluate from a separation column flows. The ion-exchange tube sheet is accommodated in a container. The container provides a regenerant flow channel so that a regenerant is allowed to flow on both sides of the ion-exchange tube sheet. | 12-23-2010 |
20110042289 | FILTER WITH SUPPORT CAGE - The invention relates to a filter element for a chromatographic column ( | 02-24-2011 |
20110042290 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 02-24-2011 |
20110049030 | Chromatography Column With Large Diameter End Fitting Openings - A column for use in chromatography, the column having a tube with a bore that can contain a packing medium captured between two porous plugs positioned at opposite ends. End fittings are attached to the tube ends, the end fittings having a duct with a duct opening having a diameter at least as large as the diameter of the tube bore which it faces. The duct opening may be positioned within a recess in spaced apart relation to the porous plugs to prevent the end fitting from contacting the plug and burnishing its surface. | 03-03-2011 |
20110049031 | Device for generating micro- and nanoflow mobile phase gradients for high-performance liquid chromatography - A device for generating micro- and nanoflow mobile phase gradients for high performance liquid chromatography includes a generator of micro- and nanoflows of at least two mobile phases in different percentage compositions; an n-position gradient distributor having inlet and outlet ports and n couples of ports for a like number of capillary loops, each selectively connectable at one end with the inlet port and at its other end to the outlet port, which in turn is connectable to an analytical circuit that includes a chromatographic column and a detector; a micro- and nanoflow meter connected to the analytical circuit; a flow deviator having an inlet connected to the outlet of the gradient distributor, one outlet connected to a discharge and another outlet connected to the micro- and nanoflow meter, and a control unit that includes means of control of the generator of micro- and nanoflows such to create the different mobile phase mixture compositions, means for controlling the gradient distributor, means for controlling the position of the flow deviator and means for controlling the throughput of the generator of micro- and nanoflows on the basis of data received from the micro- and nanoflow meter. | 03-03-2011 |
20110089095 | SEPARATING AGENT FOR OPTICAL ISOMERS AND SEPARATION COLUMN FOR OPTICAL ISOMERS - This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube. | 04-21-2011 |
20110094953 | CHROMATOGRAPHY COLUMN - A chromatography column includes a tube, a fit assembly, a first end fitting and a second end fitting. An annular protrusion extends from an end face of the tube to a protrusion height and circumscribes a chamber in fluid communication with the axial bore. Both the chamber and the bore may be filled with a packing material. The fit assembly includes a deformable ring having a yield strength less than a yield strength of the annular protrusion. The ring contacts the annular protrusion such that the frit assembly provides a chamber boundary that retains the packing material. The first end fitting is securely fastened to the tube such that the ring is axially compressed and deformed around the annular protrusion, the chamber height is less than the protrusion height, and the packing material is compressed. | 04-28-2011 |
20110094954 | VALVE FOR USE IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY HAVING A SPHERICAL SEAT WITH BEVELED OUTER FACES - A valve for use in high-performance liquid chromatography has a spherical seat and a ball that, when it abuts against the seat, constrains a fluid from flowing through the valve and is capable of moving axially in order to allow the fluid to flow through the valve. The spherical seat has beveled outer faces in order that a force acting on the valve along the axial direction will generate a force acting on the ball. The inclination of the beveled outer face is such that a force acting on the ball counteracts a force exerted on the spherical seat by the ball and essentially compensates it. | 04-28-2011 |
20110094955 | SEPARATING AGENT FOR OPTICAL ISOMERS AND SEPARATION COLUMN FOR OPTICAL ISOMERS - This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube. | 04-28-2011 |
20110114549 | MICROFLUIDIC DEVICE COMPRISING SEPARATION COLUMNS - A microfluidic chip comprises a first substantially linear separation column having a first length, the first separation column comprising a first stationary phase particle density distribution along the first length; and a second substantially linear separation column having a second length connected in series with the first separation column, the second separation column comprising a second stationary phase particle density distribution along the second length. | 05-19-2011 |
20110120926 | PRE-ASSEMBLED SEPARATION COLUMNS - There is provided an integrated system for liquid separation, such as LC, CE, affinity chromatography, and ion exchange chromatography, comprising a column and end-fittings embedded in a plastic material, such as a thermoplastic polymer. The system may further comprise an electrospray emitter directly connected with the outlet of the column, wherein a substantial part of the emitter is covered with the polymer material. There is also provided a method by which a separation column along with the accompanying end fittings for connection with adjacent liquid conduits is embedded in a polymer matrix. This configuration e.g. ensures that the factory-made, correct attachment of the fittings to the column is preserved (since the matrix prevents further user intervention, accidental or otherwise). Accordingly, the responsibility for the correct attachment of the fittings is shifted from the end user to the manufacturer. | 05-26-2011 |
20110147292 | CELLULOSE HYDRATE MEMBRANE, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF - There is provided a cellulose hydrate membrane having a porous double structure which consists of micropores having a diameter in the range from >100 nm to 20 μm and ultrapores which have a diameter of <100 nm and which are not accessible to Blue Dextran having an average molecular weight Mw of 2 000 000, wherein the fraction of the volume of the ultrapores is more than 15% of the entire pore volume accessible to water. In addition, a method for producing the membrane, its use as an adsorption membrane, and an apparatus for membrane chromatography are specified. | 06-23-2011 |
20110174708 | SAMPLE STIRRING DEVICE, LIQUID CHROMATOGRAPHY DEVICE USING SAME, AND SAMPLE CONTAINER STAND - A sample stirring device of the present invention includes a driving roller and two follower rollers for coming into contact with a sample container including a cylindrical portion for containing a sample to be stirred. The driving roller is driven for rotation to stir the sample contained in the sample container. The two follower rollers have rotation axes inclined with respect to an axial direction of the cylindrical portion. This arrangement allows the sample container such as a blood collection tube to be rotated stably. | 07-21-2011 |
20110186497 | SEALING CONFIGURATION WITH METAL-COATED STRUCTURE - A sealing configuration is configured for sealingly coupling a first fluid flow path of a first device to a second fluid flow path of a second device. The sealing configuration comprises a contact surface comprising a structure configured for increasing a surface pressure when coupling the first device to the second device. The contact surface comprises a metal coating configured for increasing sealing. | 08-04-2011 |
20110192778 | INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 08-11-2011 |
20110210055 | HIGH CAPACITY ION CHROMATOGRAPHY STATIONARY PHASES AND METHOD OF FORMING - The present invention provides a new design for high capacity stationary phases for chromatography, for example, ion chromatography. The stationary phases include a first polymer layer in contact with and at least partially coating the substrate of the stationary phase. The first polymer layer serves as a foundation for the attachment, and in various embodiments, the growth and attachment, of a highly hyperbranched polymer structure, typically based on one or more products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the hyperbranched polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound. | 09-01-2011 |
20110210056 | GAS PHASE APPROACH TO IN-SITU/EX-SITU FUNCTIONALIZATION OF POROUS GRAPHITIC CARBON VIA RADICAL-GENERATED MOLECULES - Embodiments disclosed herein include graphitic stationary phase materials functionalized through a gas-phase functionalization reaction, as well as and methods for making and using these materials, including the use of these materials in separation technologies such as, but not limited to, chromatography and solid phase extraction. In an embodiment, a functionalized graphitic stationary phase material may be prepared from high surface area porous graphitic carbon and a radical forming volatilized functionalizing agent. The radical forming volatilized functionalizing agent produces an intermediate that forms a covalent bond with the surface of the porous graphitic material and imparts desired properties to the surface of the graphitic carbon. | 09-01-2011 |
20110210057 | MULTICAPILLARY COLUMN FOR CHROMATOGRAPHY AND SAMPLE PREPARATION - A multicapillary column especially useful for liquid chromatography and sample preparation comprising a plurality of uniform capillaries coated with an insoluble stationary phase, wherein the thickness of the stationary phase is correlated with the radius of the individual capillaries for high efficiency. | 09-01-2011 |
20110240541 | MONOLITHIC COLUMN TECHNOLOGY FOR LIQUID CHROMATOGRAPHY - A monolith for liquid chromatography is disclosed that involves a reaction product of; a (1) crosslinker having at least three adjacent groups, selected from ethylene oxide, polyethylene oxide, and mixtures thereof, and two or more pendent vinyl groups, and (2) monomer having the formula, CH | 10-06-2011 |
20110278214 | Liquid-Chromatography Conduit Assemblies Having High-Pressure Seals - A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits. | 11-17-2011 |
20110284446 | Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH. | 11-24-2011 |
20110284447 | MONOLITH SEPARATION MEDIUM FOR CHROMATOGRAPHY AND PROCESS FOR PRODUCING THE SAME - To obtain a non-particle-aggregation-type organic polymer monolith separation medium, there is provided a monolith separation medium comprising a skeletal phase and pores being continuous in the form of three-dimensional network, which skeletal phase on its surface has a functional group permitting introduction of a new functional group. The skeletal phase has a non-particle-aggregation-type co-continuous structure having an average diameter of submicron to micrometer size, and is constituted of an addition polymer from an epoxy compound of bi- or higher functionality and an amine compound of bi- or higher functionality. Further, the skeletal phase is enriched in organic matter and does not contain any carbon atoms derived from aromatic series. | 11-24-2011 |
20110303599 | LIQUID CHROMATOGRAPH, LIQUID CHROMATOGRAPH COLUMN AND FILTER FOR LIQUID CHROMATOGRAPH COLUMN - In a liquid chromatograph, the disulfide adsorption of iron atoms in a filter for a column is avoided and thus peak tailing in a chromatogram is prevented to thereby prevent a lowering in the sample recovery rate. A liquid chromatograph column comprising a hollow tubular column body, a bead-shaped packing material which is packed in the hollow part of the column body, a filter provided with a mesh which has a mesh size smaller than the particle diameter of the packing material, and a cap which presses the filter against the packing material to thereby enclose the packing material within the column body, characterized in that the main component of the filter is nickel or hastelloy. | 12-15-2011 |
20110315618 | METHOD FOR MANUFACTURING PACKING MATERIAL, PACKING MATERIAL, AND COLUMN - A method for manufacturing a packing material includes a first step of reacting an inorganic particle having a hydroxyl group with a silane coupling agent including a silane coupling agent having an alkenyl group with a carbon number of 2 or more and 8 or less and/or an alkynyl group with a carbon number of 2 or more and 7 or less and a second step of reacting the inorganic particle having reacted with the silane coupling agent, with a compound represented by a general formula of: | 12-29-2011 |
20120031827 | AGGLOMERATION OF HIGH SURFACE AREA RARE EARTHS - The subject invention relates generally to friable metal oxide agglomerates and specifically to agglomerates containing high surface area rare earth-containing materials and a polymeric binder. | 02-09-2012 |
20120037555 | Chromatography Column - A chromatography column comprises a tubular member ( | 02-16-2012 |
20120061305 | MICROFLUIDIC SIEVE VALVES - Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing liquid solution to pass through the valve. The valves find particular use in making microfluidic chromatography modules. | 03-15-2012 |
20120061306 | FILTER HOLDER IN A CHROMATOGRAPHY COLUMN - A filter holder to be used in a chromatography column is provided. Said filter holder comprising a filter squeezing part ( | 03-15-2012 |
20120074051 | FLUID DISTRIBUTOR UNIT - A fluid distributor unit comprising a channel system where one or more inlet channels ( | 03-29-2012 |
20120085692 | INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 04-12-2012 |
20120103886 | SAMPLE DISTRIBUTION DEVICE FOR DISTRIBUTION OF SAMPLES IN LIQUID CHROMATOGRAPHS - A sample distribution device for distribution of samples in liquid chromatographs comprises a sample supply channel arranged in a holding element. The holding element includes a receiving chamber, with the sample supply channel leading into the receiving chamber. Internally of receiving chamber, a distributing element is arranged. The passage openings for passage of the sample are formed by an inner side of the receiving chamber and by an outer side of the distributing element; preferably, for this purpose, the distributing element has recesses on the outer side. The sample distribution device is arranged in a device for liquid chromatography, wherein the sample will flow radially through the chromatography resin. | 05-03-2012 |
20120103887 | Liquid Chromatograph System - A channel-switching valve into which a high-pressure liquid and a low-pressure liquid flow is provided. The channel-switching valve includes a stator and a rotor which has a surface in contact with one surface of the stator and rotates while sliding on the contact surface. The stator has a plurality of liquid flow ports open to the contact surface, and the rotor has a plurality of channel grooves for connecting the liquid flow ports. One of the channel grooves is a straight groove passing through the rotational center of the rotor, and the other channel grooves are line-symmetrically arranged with respect to the straight channel groove. Alternatively, among the channel grooves, the channel grooves into which the high-pressure liquid flows are configured to be located on both sides of the rotational center of the rotor. As a result, a local load acting on the rotor during a high-pressure liquid-feeding process is reduced, so that the contact surface is prevented from being scraped off by the edge of the opening of a port during the rotation of the rotor. | 05-03-2012 |
20120118805 | METHODS AND APPARATUS FOR MAKING A CHROMATOGRAPHY COLUMN - Methods for depositing a stationary phase in a tube for chromatography, in particular, as a variable gradient column are disclosed. The methods include providing a tube, loading the tube with a concentration gradient of a stationary phase precursor along its length, and removing the solvent such that the stationary phase precursor is deposited within the tube as a stationary phase to form a chromatography column. The concentration gradient is formed by combining at least a first fluid and a second fluid, with the first fluid containing the stationary phase precursor in a solvent. | 05-17-2012 |
20120118806 | METHODS AND APPARATUS FOR MAKING A CHROMATOGRAPHY COLUMN - Methods for depositing a stationary phase in a tube for chromatography. The resulting column may be a variable gradient column or a standard open tubular column with a uniform thickness stationary phase. The methods include providing a tube comprising an electrically conductive interior surface and having a composition within the tube, the composition comprising a stationary phase precursor and at least one of an electrolyte and a reactant precursor, and electrochemically reacting the reactant precursor or the stationary phase precursor to form a stationary phase in the tube. | 05-17-2012 |
20120118807 | CHROMATOGRAPHY APPARATUS - A chromatographic apparatus is provided comprising a housing, a fluid inlet to the housing, a fluid outlet from the housing, an optional vent and a chromatographic packed bed in the housing. The fluid inlet and fluid outlet and optional vent are provided with connectors that connect a fluid inlet and a fluid outlet on other such chromatographic apparatus. | 05-17-2012 |
20120138520 | SEPARATION PROCESS - The present invention relates to a process for separating a target radiolabelled compound from an impurity, apparatus for performing such a process and a removable cassette for use in such apparatus. Also provided are methods for using the target radiolabelled compound obtained by a method comprising the separating process of the invention. | 06-07-2012 |
20120145616 | Bag For A Circuit Of A Biological Liquid Treatment Installation - The invention concerns a bag comprising a first conduit ( | 06-14-2012 |
20120145617 | MULTI-FUNCTIONAL OPTION VALVE, MULTIFUNCTIONAL FULLY AUTOMATIC LIQUID CHROMATOGRAPHY SYSTEM INCLUDING THE SAME, AND METHOD FOR ANALYZING SAMPLE USING THE SAME - Provided is a multifunction selection valve for use in a liquid chromatography system. The multifunction selection valve includes multiple ports to which both ends of a 1st dimension separation column may be connected at a part thereof, the multifunction selection valve including: a fluid passing mode in which a fluid introduced thereto is not passed through the 1st dimension separation column but is discharged; a column passing mode in which the fluid introduced thereto is passed through the 1st dimension separation column and then discharged; and a fluid blocking mode in which the fluid is prevented from being introduced. When using the multifunction selection valve, it modifies the flow paths of chromatographic solvents so that the resultant multifunctional liquid chromatography system allows one-dimensional separation, two-dimensional separation, on-line digestion and on-line phosphopeptide enrichment by a single binary pump. | 06-14-2012 |
20120160754 | DUAL MATERIAL APPROACH FOR HIGH PRESSURE BIO INERT FLOW PATH COMPONENTS - A method of manufacturing a component ( | 06-28-2012 |
20120187033 | FLASH CHROMATOGRAPHY CARTRIDGE - A low pressure liquid chromatographic cartridge has a tubular polymer container that receives a chromatographic packing material. The container has an outlet port located at its downstream end and container threads formed on its upstream end. A polymer cap, with an inlet port on an upstream end, screws onto the container threads. A flange depending from the cap mates with the lip of the container to form a fluid tight seal between the polymer cap and container suitable for use in low pressure liquid chromatography. | 07-26-2012 |
20120193277 | FLASH CHROMATOGRAPHY CARTRIDGE - A low pressure liquid chromatographic cartridge is provided having a tubular polymer container adapted to receive a chromatographic packing material. The container has an outlet port located at a downstream end of the container and container threads formed on an upstream end of the container. A polymer cap having cap threads located on the cap threadingly engage the container threads. An inlet port is located on an upstream end of the cap. A resilient fluid tight seal is interposed between the polymer cap and container suitable for use in low pressure liquid chromatography. A locking tab on a skirt of the cap engages a recess on the container when the seal engages the cap and container to lock the cap in position relative to the container. | 08-02-2012 |
20120193278 | Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same - Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities even at high conductivities and pH. | 08-02-2012 |
20120205304 | Self-Unlocking Fluid-Tight Connector - A connector is used to connect a conduit to a threaded orifice of a fluidic component, such as a component of an apparatus for chromatography. The connector includes a flexible fitting, a deformable fitting, and a compression fitting. The flexible fitting fixes the position of the conduit with respect to the threaded orifice. The deformable fitting provides a fluid-tight seal between the fluidic conduit and the threaded orifice. The compression fitting includes an external-thread portion for attachment to the orifice, to urge the flexible fitting toward an outer surface of the fluidic conduit, and to urge the deformable fitting toward both the outer surface and the orifice, a cam portion in mechanical communication with the flexible fitting via a through-hole in the external thread portion, and a graspable portion in rotatable communication with the cam portion. | 08-16-2012 |
20120248020 | CHROMATOGRAPHY DEVICES AND METHODS - Provided are chromatography devices having a stationary phase that includes patchy particles having at least two different surface chemistries, such as Janus particles. Also provided are methods of separating at least one analyte out of a sample, where the method includes adding a sample having at least one analyte to a chromatography device that includes a stationary phase that includes a plurality of patchy particles. Further provided are methods that include packing a chromatography column with a plurality patchy particles having at least two different surface chemistries. Additional embodiments are disclosed. | 10-04-2012 |
20120255894 | METHOD FOR COVALENTLY ATTACHING POLYMERIC MONOLITHS TO POLYETHER ETHER KETONE (PEEK) SURFACES - Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces The present invention provides a method of covalently attaching a polymeric monolith to the internal surface of polyether ether ketone (PEEK) tubing and column housings, comprising the steps of: (a) reducing the ketone group of the PEEK to a hydroxyl group to obtain a modified PEEK, (b) optionally reacting the hydroxyl group obtained in step (a) with a compound having an active vinyl group to form a modified PEEK selected from the group of acrylate modified PEEK, methacrylate modified PEEK, styrene modified PEEK and epoxy modified PEEK, and (c) reacting the modified PEEK obtained in step (a) or (b) with a polymer or polymerization mixture for forming the polymeric monolith. Hereby, the mechanical stability and solvent durability of larger diameter monolithic columns as well as their overall performance are improved. | 10-11-2012 |
20120267299 | METHOD FOR DRY PACKING CHROMATOGRAPHY COLUMNS - The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column. | 10-25-2012 |
20120273404 | HIGH PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER - The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier | 11-01-2012 |
20120292242 | COLUMN FOR LIQUID CHROMATOGRAPHY - Chromatography column comprising a column tube and at least one adjustable adapter assembly with a plunger that may be positioned at a plurality of longitudinal positions in the column tube, wherein the piston is arranged at the end of a threaded piston rod arranged with the threads engaged by a rotable end cap for enabling longitudinal movement of the piston by turning the end cap, and wherein the adaptor assembly comprises rotation prevention means arranged to prevent rotation of the plunger rod in response to turning of the end cap. | 11-22-2012 |
20120305464 | ON-LINE SAMPLING FROM A PROCESS SOURCE - An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee. | 12-06-2012 |
20130001145 | Micro-Machined Frit and Flow Distributor Devices for Liquid Chromatography - A micro-machined frit is provided for use in a chromatography column, having a substrate with a thickness, and holes extending through the thickness and providing fluid communication through the substrate. A micro-machined flow distributor is provided for use in a chromatography column having a substrate, holes extending through the substrate, and channels in fluid communication with the holes. A micro-machined integrated frit and flow distributor device is also provided having a substrate with a thickness, holes extending through the thickness and providing fluid communication therethrough, and channels in fluid communication with at least one of the holes. A chromatography column is provided having a tube, an extraction medium contained therein, and a micro-machined frit positioned proximate an end of the tube. The column can include a micro-machined flow distributor positioned between the frit and the end of the tube. | 01-03-2013 |
20130015114 | MIXER FOR INSERTION INTO A ROTOR OF A CENTRIFUGE - A mixer for insertion into a rotor of a centrifuge has a mixing trough and an obstacle device with at least one obstacle. The at least one obstacle is configured in order to influence the flow of a liquid present in the mixing trough. In response to a rotation of the rotor, with a specified incorporation of the mixer in a holder of the rotor, a spacing between at least one wall section of the mixing trough and the obstacle device is variable such that the liquid present in the mixing trough flows around the obstacle of the obstacle device. | 01-17-2013 |
20130032520 | LIQUID CHROMATOGRAPH, DEVICE AND METHOD FOR CALCULATING ELUTION TIME, AND DEVICE AND METHOD FOR DETERMINING MIXTURE RATIO - Provided that elapsed time from the start of the flow-in of an eluent into a column is t | 02-07-2013 |
20130056401 | GAS PHASE APPROACH TO IN-SITU/EX-SITU FUNCTIONALIZATION OF POROUS GRAPHITIC CARBON VIA RADICAL-GENERATED MOLECULES - Embodiments disclosed herein include graphitic stationary phase materials functionalized through a gas-phase functionalization reaction, as well as and methods for making and using these materials, including the use of these materials in separation technologies such as, but not limited to, chromatography and solid phase extraction. In an embodiment, a functionalized graphitic stationary phase material may be prepared from high surface area porous graphitic carbon and a radical forming volatilized functionalizing agent. The radical forming volatilized functionalizing agent produces an intermediate that forms a covalent bond with the surface of the porous graphitic material and imparts desired properties to the surface of the graphitic carbon. | 03-07-2013 |
20130062267 | PACKING SYSTEM AND METHOD FOR CHROMATOGRAPHY COLUMNS - The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of:
| 03-14-2013 |
20130075317 | MULTICAPILLARY MONOLITH - The invention relates to a monolithic porous material made of amorphous silica or activated alumina, comprising substantially rectilinear capillary channels that are parallel to one another, wherein: | 03-28-2013 |
20130134082 | FITTING ELEMENT WITH HYDRAULIC GRIP FORCE ELEMENT - A fitting element ( | 05-30-2013 |
20130134083 | Liquid-Chromatography Conduit Assemblies Having High-Pressure Seals - A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits. | 05-30-2013 |
20130153479 | INTEGRATED HIGH THROUGHPUT SYSTEM FOR THE ANALYSIS OF BIOMOLECULES - Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules. | 06-20-2013 |
20130161248 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 06-27-2013 |
20130193051 | METHOD OF PACKING CHROMATOGRAPHIC COLUMNS - Improved methods for packing a chromatographic column and columns packed by these methods are provided. The methods include introducing a packing material into a chromatographic column, while simultaneously ultrasonicating and applying pressure to the packing material to form a packed column with radial homogeneity. | 08-01-2013 |
20130193052 | Chromatography Columns - If one manufactures chromatography column tubes from plastic/thermoplastic or composite materials (such as polypropylene (PP), polyethylene (PE), polyamides, acetals, or glass-filled plastics, such as glass-fiber plastics) and secures at least one of two flow distributors within the column tube with a tight interference or press fit, the resulting chromatography columns reduce or avoid the formation of dead zones around the press fit flow distributor and have an infinitely adjustable packing medium volume, also known as the medium “bed height.” | 08-01-2013 |
20130199981 | FERRULE CHUCK WITH SURFACE MICRO-GRIP - A fitting for coupling a capillary to another component of a fluidic device is disclosed. The fitting includes a ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component; a ferrule chuck configured for enclosing a back part of the capillary; and a housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule. | 08-08-2013 |
20130206665 | SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS - The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution. | 08-15-2013 |
20130206666 | Process For Preparing Liquid Mixtures Of Known pH And Salt Concentration - A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more salts, and one or more solvents, and the method comprises the steps of: i) calculating pH and/or salt concentration at a particular time t from a user-determined gradient function; and ii) based on the values obtained in step (i), calculating percent acid, percent base, percent salt and percent solvent in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided. | 08-15-2013 |
20130206667 | APPARATUS FOR MAKING A CHROMATOGRAPHY COLUMN - Variable geometry columns for chromatography are disclosed that include a tube having an interior surface and an inlet end and an outlet end, a stationary phase deposited along substantially the length of the interior surface of the tube, and/or deposited on surface area-increasing members positioned within the tube. The resulting column has a gradually enlarging cross-sectional area that is narrower at the inlet end than toward the outlet end attributable to (1) the cross-section of the tube, (2) a variable deposition of the stationary phase, or (3) a combination thereof. | 08-15-2013 |
20130228501 | PREPARATIVE CHROMATOGRAPHY COLUMN - A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column. | 09-05-2013 |
20130228502 | FLASH CHROMATOGRAPHY CARTRIDGE - A low pressure liquid chromatographic cartridge has a tubular polymer container that receives a chromatographic packing material. The container has an outlet port located at its downstream end and container threads formed on its upstream end. A polymer cap, with an inlet port on an upstream end, screws onto the container threads. A flange depending from the cap mates with the lip of the container to form a fluid tight seal between the polymer cap and container suitable for use in low pressure liquid chromatography. | 09-05-2013 |
20130240426 | METHOD FOR SECURING A DISTRIBUTOR PLATE TO A BACKING PLATE OF A CHROMATOGRAPHY COLUMN AND A CHROMATOGRAPHY COLUMN - The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum that is generated internally within the column to affix the distributor to the backing plate. | 09-19-2013 |
20130256204 | Supporting plate of a device - A supporting plate of a device is suggested. The device has at least one component and a housing for at least partly protecting the component. The supporting plate has at least one receiving element adapted for accepting the at least one component of the device in at least one of the following manners: in a form-closed manner, in a force-closed manner. The supporting plate is part of the housing. | 10-03-2013 |
20130264263 | METHODS AND COMPOSITIONS FOR CHROMATOGRAPHY - The present invention is directed to methods and compositions for separating and isolating target molecules. In particular, the present invention comprises devices, such as CCDs, that contain particles without the need for support structures. Chromatography separation techniques, including but not limited to, ion exchange, size separation, affinity chromatography, ion exclusion, ligand exchange, reversed phase and normal phase partitioning, are used in the CCD. Methods also include low, medium and high pressure liquid chromatography. Such methods can be used for analytical, semi-preparative processes, initial clarification, preparative filtration and process scale applications. | 10-10-2013 |
20130270167 | DISPOSABLE HORIZONTAL OR RADIAL FLOW TYPE CHROMATOGRAPHIC COLUMN - A liquid chromatography column, utilizing horizontal or radial flow of sample material passing there through, preferably in inward direction, comprising: a housing defining a chamber therein and including at least one removable end section, e.g. screw lid; a first and second longitudinally extending porous fits positioned within said chamber of said housing; a bed or packing of, preferably particulate, chromatographic separation material positioned within said chamber of said housing and intermediate said porous frits, the first of said porous frits being adjacent said housing and an inlet channel, the second of said porous frits being positioned adjacent a core member and an outlet channel; distribution means operatively connected to said inlet channel; collector means operatively connected to said outlet channel, said distribution means and said inlet channel being constructed to direct associated material to be separated in said bed evenly across a longitudinal length of said bed in a substantially horizontal direction. | 10-17-2013 |
20130306535 | Preparative Separation-Purification System - In a preparative separation-purification system for passing a solution containing a target component through a trap column | 11-21-2013 |
20130306536 | Preparative Separation-Purification System - In a preparative separation-purification system for passing a solution containing a target component through a trap column to capture the target component in the column, and for subsequently passing an eluting solvent through the column to elute the captured component and collect it in a container, a dilution passage is merged with a collection passage for sending an eluate from the outlet end of the trap column to the collection container, and a diluting liquid is intermittently introduced through the dilution passage into the collection passage. The diluting liquid lowers the concentration of the target component in the eluate and impedes the deposition of the target component. Thus, clogging of the passage due to the deposition of the target component eluted from the trap column is effectively prevented. | 11-21-2013 |
20130306537 | Preparative Separation-Purification System - An eluate-collecting mechanism is constructed, including: a collection passage and having an inlet to be inserted into and removed from the upper end of a trap column and an outlet to be inserted into and removed from a collection container; a support member for supporting the collection passage in such a manner that the inlet is fixed while the outlet is vertically movable; a contact part provided at the outlet to come in contact with the collection container when the outlet is inserted into this container; and an elastic member for pressing the outlet downward so that a tip of the outlet is lower than the tip of the inlet, the elastic member being compressed when the support member and the collection container are brought closer to each other while keeping the contact part in contact with the container. | 11-21-2013 |
20130334117 | SYSTEM AND METHOD OF COOLING A PUMP HEAD USED IN CHROMATOGRAPHY - An actuator has a support plate, a pump head in thermally conductive contact with the support plate, and an actuator body. Cooling means is disposed between the support plate and the actuator body. The cooling means is configured to remove and transfer heat from the pump head to the actuator body. In one embodiment, the cooling means includes two thermally conductive plates (called cold-side and hot-side plates) and a thermoelectric device disposed in thermally conductive contact between the cold-side and hot-side plates. The cold-side plate is in thermal communication with the pump head through the support plate. The hot-side plate is in thermal communication with the actuator body. The thermoelectric device is configured to transfer heat from the cold-side plate, which is in thermal communication with the pump head, to the hot-side plate, which is in thermal communication with the actuator body, thereby removing heat from the pump head. | 12-19-2013 |
20130334118 | COATED CAPILLARY WITH REMELTED COATING FOR FRONT SIDED SEALING - A method of manufacturing a sealing fluidic component based on a capillary enclosing a fluid conduit and having an exterior surface being at least partially coated with a coating of a meltable material, wherein the method comprises melting the meltable material of the coating at least at an end portion of the capillary, and resolidifying the melted material to thereby form, at the end portion, a sealing integral with the coating and constituted at least partially by the meltable material. | 12-19-2013 |
20130341260 | SEALED FLUIDIC COMPONENT COMPRISING A COMPOSITE MATERIAL OF DIFFERENT PAEK MATERIALS - A sealed fluidic component ( | 12-26-2013 |
20140021116 | HPLC FRIT FILTER ASSEMBLY - An apparatus and method for creating a high pressure chromatography frit filter assembly is described. The frit is positioned in bondable contact with a polymer ring and then the frit is subject to inductive or targeted heating to cause the frit material to heat the adjacent polymer ring from the inside out. The polymer to liquefies and flow into and past one or more narrowing locations in the pore passageway extending from the surface of the frit to an infusion depth, which provides previously unachieved secure mechanical engagement and adherence and resistance to pressure blow by (break through) and prevents the flow of contaminants between the edge of the frit and the facing edge of the polymer ring in a high pressure or ultra-high pressure chromatography system, where inlet pressures in the range of pressures up to | 01-23-2014 |
20140021117 | Separation System - A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system is described. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. The improvement is more efficient use of the desorbent. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process. | 01-23-2014 |
20140034563 | LIQUID CHROMATOGRAPHY COMPONENT - The present invention aims to provide a liquid chromatography component including a column and a prefilter, which is hard to cause an increase of supplied liquid pressure even when the measurement of a sample is repeated. The present invention is a liquid chromatography component, which includes: a column with filler particles filled therein; and a prefilter, the filler particles having an average particle size in the range of 2 to 20 μm, the prefilter having a filtering particle size in the range of ⅙ to ⅓ of the average particle size of the filler particles. | 02-06-2014 |
20140042066 | CHANNEL UNIT FOR LIQUID CHROMATOGRAPH - A column container is formed in a bonding portion between a first support plate and a second support plate, and a column is held in the column container. An inlet channel connects the column container to a liquid inlet port. The inlet channel includes a first channel having a small diameter and a second channel having an increasing diameter. An inner surface of the second channel is a hemispherical surface. The radius of the column container is substantially the same as the radius of the hemispherical surface. The distance from an inflow end of the column to the boundary between the first channel and the second channel is substantially the same as the radius of the hemispherical surface. | 02-13-2014 |
20140110322 | CAPILLARY ASSEMBLY USEFUL AS CONNECTING CAPILLARY - There is provided a capillary assembly suitable for connecting various components of an analytical measuring device, for example a liquid chromatograph or a capillary electrophoresis device, to each other. Specifically, this involves reinforcing the fragile tubing by the addition of PEEK or steel sleeves and/or embedding the tubing in an injection-molded resin such that the tubing is not exposed directly to operator handling and manipulation. Further functional improvement is obtained by including additional components inside the resin. Thereby a versatile and robust capillary assembly is achieved. | 04-24-2014 |
20140116932 | Novel Liquid Chromatographic Media and Methods of Synthesizing the Same - The present invention provides a bisamide-containing novel liquid chromatographic media and method of synthesizing the same. A novel polar bisamide functional group, which can form hydrogen bonds or ion pairs with residual silanols on the surface of silica gel, is used as the bonded phase on the surface of silica gel to better shield the activity of silanols and to eliminate the influence of residual silanol groups. Compared with conventional C18 columns, these novel bonded phases have different selectivity; they can work not only in 0 to 100% water but also in 0 to 100% organic mobile phase. In particular, they exhibit good peak shapes and resolutions for polar and basic compounds and have good stability within a very wide pH range. These properties make the new stationary phases a useful complement to conventional C18 columns for a variety of HPLC applications. | 05-01-2014 |
20140144825 | FLASH CHROMATOGRAPHY CARTRIDGE - A low pressure liquid chromatographic cartridge has a tubular polymer container that receives a chromatographic packing material. The container has an outlet port located at its downstream end and container threads formed on its upstream end. A polymer cap, with an inlet port on an upstream end, screws onto the container threads. A flange depending from the cap mates with the lip of the container to form a fluid tight seal between the polymer cap and container suitable for use in low pressure liquid chromatography. | 05-29-2014 |
20140158599 | LIQUID CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH PRESSURE SEALS - Described is a tubing assembly which includes a permanently deformable outer tube, an intermediate tube and an inner tube. A radial seal is provided by a uniform radial crimp having a non-zero longitudinal length at a longitudinal location on the tubing assembly. In some embodiments one or both ends of the assembly have a uniform radial crimp and are polished so that the ends of two or more of the tubes are substantially flush with each other to thereby block the passage of fluids between the ends of the tubes. In other embodiments the uniform radial crimps are at other longitudinal locations where a high pressure seal is desired. The longitudinal length and the depth of each uniform radial crimp can be formed to accommodate the requirements of a particular application so that leakage along the tubing assembly is prevented and void volume is reduced or eliminated. | 06-12-2014 |
20140166562 | CHROMATOGRAPHY COLUMN ASSEMBLY - Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations. | 06-19-2014 |
20140231330 | CLAMPING DEVICE FOR CLAMPING A PLURALITY OF COLUMNS FOR SAMPLE PREPARATION - According to the invention, this object is achieved by a clamping device for clamping a plurality of columns for sample preparation which provides for a plurality of clamping blocks and a displacement mechanism for displacing at least one clamping block relative to an opposing clamping block between an open position and a clamping position. In this instance, in the open position, a column can be inserted between two opposing clamping blocks and, in the clamping position, the inserted column is clamped between the opposing clamping blocks in order to produce a fluid connection between the column and at least one of the opposing clamping blocks. In this instance, at least three clamping blocks are retained in a row one behind the other on a guiding rail so that at least two columns can be clamped in an axial direction one behind the other between the clamping blocks. The slidingly displaceable clamping blocks which are retained on the guiding rail are connected to the displacement mechanism by coupling means in such a manner that an actuation of the displacement mechanism from the clamping position into the open position brings about a displacement of all the slidingly displaceable clamping blocks and the columns are released. | 08-21-2014 |
20140251886 | MIXER FOR INSERTION INTO A ROTOR OF A CENTRIFUGE - A mixer for insertion into a rotor of a centrifuge has a mixing trough and an obstacle device with at least one obstacle. The at least one obstacle is configured in order to influence the flow of a liquid present in the mixing trough. In response to a rotation of the rotor, with a specified incorporation of the mixer in a holder of the rotor, a spacing between at least one wall section of the mixing trough and the obstacle device is variable such that the liquid present in the mixing trough flows around the obstacle of the obstacle device. | 09-11-2014 |
20140263011 | NOVEL CHROMATOGRAPHIC MEDIA BASED ON ALLYLAMINE AND ITS DERIVATIVE FOR PROTEIN PURIFICATION - Chromatographic media of porous media particles derivatized with allylamine or polyallylamine obtained directly or through intermolecular polymerization on the surface thereof and such media functionalized with further functionalization groups. Such media are particularly useful for separating biomolecules. | 09-18-2014 |
20140263012 | PARALLEL ASSEMBLY OF CHROMATOGRAPY COLUMN MODULES - A parallel assembly ( | 09-18-2014 |
20140284259 | POROUS INORGANIC/ORGANIC HYBRID PARTICLES FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR ITS PREPARATION - Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and that offer more efficient chromatographic separations than that known in the art. | 09-25-2014 |
20140319042 | ELECTROSPRAY INTERFACE TO A MICROFLUIDIC SUBSTRATE - An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal. | 10-30-2014 |
20140326649 | NOVEL NANOCOMPOSITES AND THEIR APPLICATION AS MONOLITH COLUMNS - Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionally capable of chemically interacting with a surface of a second material are described. The hybrid inorganic/organic materials have enhanced wall adhesion and increased resistance to shrinkage as compared to prior art monolith materials. The improved adhesion of the monoliths enable the preparation of capillary columns with an internal diameter (I.D.)≧50 μm. | 11-06-2014 |
20140326650 | Pump and injector for liquid chromatography - A combined dual pump-injector valve utilizing a single piece of material to house the barrel for each of the two piston-based pumps and to provide the stator of the associated valve, thus eliminating any need for connections between the pumps and the valve, and therefore eliminating the potential for high-pressure leaks or pressure reductions. The combined dual pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample. | 11-06-2014 |
20140346101 | LATERALLY PERFUSED CHROMATOGRAPHY ELEMENT - A microfluidic chromatography element in which all components are situated in one plane and the mobile phase perfuses the stationary phase laterally. | 11-27-2014 |
20140367319 | HYBRID GRADIENT DELIVERY SYSTEM AND OPERATION - A liquid chromatography system includes a gradient proportioning valve in fluidic communication with sources of solvent. From the solvent sources, the gradient proportioning valve produces a low-pressure gradient stream. A first pump is in fluidic communication with the gradient proportioning valve to receive, pressurize, and move the pressurized low-pressure gradient stream to a flow-combining device. A second pump operates in parallel with the first pump and moves a pressurized solvent stream to the flow-combining device where the pressurized solvent stream combines with the low-pressure gradient stream to produce a high-pressure gradient stream. A second gradient proportioning valve can produce, from a second plurality of sources of solvent, a second low-pressure gradient stream, wherein the solvent stream moved by the second pump to the flow-combining device and combined with the other low-pressure gradient stream comprises the second low-pressure gradient stream. | 12-18-2014 |
20150041381 | CHROMATOGRAPHY COLUMN - Chromatography columns having at least one assembly comprising a backing plate adhesively bound to a flow distributor, and methods of making and using the columns are disclosed. | 02-12-2015 |
20150048015 | CORROSION PROTECTION IN TUBING USED IN CHROMATOGRAPHY - An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold. The corrosion-resistant nature of the material protects the end of the tube from corrosion or erosion, which improves the quality and reliability of a seal between the end face of the tube and a sealing surface of the port. Alternatively, or in addition to covering the end face of the tube with the corrosion-resistant material, a gasket covered with or made of the corrosion-resistant material can be disposed between the end face of the tube and the port. This gasket extends the reach of the tube to facilitate bottoming out the tube within the port. | 02-19-2015 |
20150060342 | Porous Adsorptive Or Chromatographic Media - A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments. | 03-05-2015 |
20150299409 | METHOD FOR THE PREPARATION OF MONOLITHIC COLUMNS - A method of preparing a separation column, or channel in a microfabricated device, includes the steps of: providing an unfilled column, or channel in a microfabricated device; activating the inner wall of the column or channel with an activating agent; filling the column with a polymerization solution including a mixture of monomers, at least one porogen and at least one polymerization initiator; and polymerizing the mixture to form a rigid porous monolithic polymer plug in the column or channel. The monomers include a mixture of divinylbenzene as major monomer and isodecylacrylate, and the at least one porogen includes isobutanol. | 10-22-2015 |
20150314218 | HIGHLY PRODUCTIVE SIMULATED MOVING BED CHROMATOGRAPHIC SEPARATION - The invention is directed to a simulated moving bed chromatographic separation process, and to a simulated moving bed chromatography apparatus for carrying out said process. The simulated moving bed chromatographic separation process of the invention comprises the steps of applying a feed mixture and a mobile phase in which said feed mixture is soluble to a simulated moving bed comprising a particulate stationary phase, and separating said feed mixture into an extract and a raffinate, wherein said simulated moving bed comprises multiple radial and/or axial flow columns connected in series into a loop, and wherein the particulate stationary phase of said simulated moving bed has a median particle diameter of 100 mm or less. | 11-05-2015 |
20150321121 | AN ADAPTOR FOR A CHROMATOGRAPHY COLUMN - An adaptor for a chromatography column, the adaptor comprising a substantially circular bottom plate provided with an end surface; a ring shaped wall element arranged at the periphery of the bottom plate. The bottom plate and the wall element having a common axis and the adaptor is provided with a filter connection arrangement for removably connecting a filter on the end surface of the bottom plate of the adaptor. | 11-12-2015 |
20150336027 | CHROMATOGRAPHY COLUMN AND METHOD OF CONDUCTING MAINTENANCE ON A CHROMATOGRAPHY COLUMN - A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction. | 11-26-2015 |
20160001199 | Chemical Reactor Device - A chemical reactor is described comprising a substrate with a fluid channel and a set of organized pillar structures positioned in the channel. The individual pillar structures have a length in the longitudinal direction of the channel and a width in the width direction of the channel whereby their width-to-length aspect ratio is at least 7. | 01-07-2016 |
20160001262 | MIXED MULTIFUNCTIONAL METAL AFFINITY SURFACES FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS - A composition for reducing the aggregate content of a protein preparation includes a first substrate having a first surface-bound ligand possessing a metal affinity functionality, the metal affmity functionality being substantially devoid of a metal, and an additional surface-bound ligand different from the first surface-bound ligand, the additional surface-bound ligand having an aggregate charge not opposite to that of the metal affinity functionality, optionally the additional surface-bound ligand is provided on an additional substrate such that the composition comprises a mixture of the first substrate and the additional substrate. | 01-07-2016 |
20160003784 | SOLUTE EXTRACTING APPARATUS - A solute trapping column including two trapping agent layers has a first branched pathway extending from an upper part of a main body part thereof, and a second branched pathway extending from between two trapping agent layers, and with its upper part a purification column is connected. By injection of solution of dioxins and supply of solvent into the purification column, dioxins are trapped by the trapping agent layers. An extraction solvent supplied from the lower end side of the solute trapping column while keeping both the purification column and the first branched pathway blocked extracts the dioxins trapped by the second trapping agent layer and flows into the second branched pathway. An extraction solvent supplied in a similar manner while keeping both the purification column and the second branched pathway blocked extracts the dioxins trapped by the first trapping agent layer and flows into the first branched pathway. | 01-07-2016 |
20160030923 | Porous Media Compositions and Methods for Producing the Same - The present invention relates to porous substrate compositions and methods for producing such compositions. In one embodiment, the porous substrate composition of the present invention comprises sintered spherical particles of a substantially uniform size. The porous media compositions of the present invention comprise relatively randomly-ordered particles with a void fraction significantly higher than compositions with a more ordered, close-packed configuration. The present invention further relates to composite porous media compositions comprising two or more relatively discrete layers of sintered particles. | 02-04-2016 |
20160059150 | SEALING CONFIGURATION WITH METAL-COATED STRUCTURE - A sealing configuration is configured for sealingly coupling a first fluid flow path of a first device to a second fluid flow path of a second device. The sealing configuration comprises a contact surface comprising a structure configured for increasing a surface pressure when coupling the first device to the second device. The contact surface comprises a metal coating configured for increasing sealing. | 03-03-2016 |
20160114262 | CHROMATOGRAPHIC FILTER - The invention provides filters and methods of assembling filters. In an exemplary embodiment, the filter includes a porous element, a compression element, and a housing. The compression element can be configured to receive the porous element, thereby forming an assembly. For example, the compression element can receive the porous element in a slip-fit relationship. The housing can have an opening formed therein that is configured to receive the assembly. In some embodiments, the assembly can be retained within the opening when the assembly is received therein. For example, the opening can receive the assembly in a press-fit relationship. | 04-28-2016 |
20160136542 | Superficially Porous Particles with Precisely Controlled Particle Density, and Methods of Preparation and Use Thereof - The invention provides superficially porous metal oxide particles with precisely controlled particle density and to methods for their preparation and use, as well as to separation devices (e.g., high pressure liquid chromatography) having superficially porous particles. | 05-19-2016 |
20160136543 | SEPARATION DEVICE AND SEPARATION METHOD - An object of the present invention is to separate a material to be separated at a low cost and constant accuracy when the material to be separated is separated from a mobile phase containing the material to be separated through the passing of the mobile phase through a stationary phase, even if the mobile phase has a large volume. A separation device characterized in that a separation column provided with a stationary phase having a volume capable of processing the entire volume of a mobile phase containing a material to be separated is provided, the separation column is replaceable, and the usage count of the stationary phase reaches a lifetime count through the processing of one batch. | 05-19-2016 |
20160144293 | Chromatography Column Distribution System - A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position. The length of the portions correspond to at least 80% of the distance between the first and outer radial position and the outer radial position. | 05-26-2016 |
20160169846 | PRE-ASSEMBLED SEPARATION COLUMNS | 06-16-2016 |
20160199753 | NOVEL NANOCOMPOSITES AND THEIR APPLICATION AS MONOLITH COLUMNS | 07-14-2016 |
20160250566 | Chromatography Column | 09-01-2016 |
20160375376 | DEVICE AND METHOD OF A SUPERCRITICAL FLUID SYSTEM FOR DETECTING ANALYTES USING A LOW PRESSURE DETECTOR - A device is provided in a supercritical fluid system, which uses a mobile phase output by a separation device, the mobile phase volumetrically expanding as it decompresses. The device includes a passive splitter and a shuttle valve. The passive splitter is configured to receive the mobile phase and to split the mobile phase into a primary flow stream and a split flow stream, where the primary flow stream is directed to a pressure maintenance device. The passive splitter is further configured to reduce pressure of the split flow stream, causing volumetric expansion of the split flow stream. The shuttle valve is configured to insert volumetric aliquots of the volumetrically expanded split flow stream into a dilution flow stream to provide a diluted split flow stream, and to direct the diluted split flow stream to a low pressure detector. | 12-29-2016 |
20190145941 | GAS CHROMATOGRAPH | 05-16-2019 |
20220134253 | MIXER SYSTEM FOR A LIQUID CHROMATOGRAPHY SYSTEM - A mixer system for a liquid chromatography system has a mixer block, a plurality of fluid inlets which are connected to a mixing chamber by a respective channel, and a fluid outlet for mixed fluid. Each channel has a valve assigned thereto which is adapted to control the fluid flow. An adapter which is attached to the mixer block and through which one of the channels passes is provided for each valve. The valve is attached to the appropriate adapter, and the valves are arranged in an annular shape around the mixer block. | 05-05-2022 |