Class / Patent application number | Description | Number of patent applications / Date published |
210635000 | Liquid/liquid or gel type (i.e., jellylike) chromatography | 64 |
20080237123 | Alkaline Regeneration of N-Methyl-D-Glucamine Funtional Resins - A method of regenerating N-Methyl-D-glu-camine-functional resin that has been used for boron-removal uses a closed recirculating loop for treating the conjugate acid salt of the N-Methyl-D-glucamine functionality of the resin. The new method reduces rinse water demand and improves pH control in a water treatment system. The new method can be used to improve the performance of boron-selective resins in stand-alone systems or as a second stage in a reverse osmosis seawater desalination system. The regeneration method is useful in any application where weakly basic anion exchange resin in the conjugate acid salt form is to be regenerated (neutralized) by alkaline treatment. Possible end use applications are in drinking water processing, agricultural water treatment, sweetener production, waste water processing, mining hydrometallurgy, and condensate polishing. | 10-02-2008 |
20080237124 | Manufacture of Chromatography Matrices - The present invention relates to a method of manufacturing a chromatography matrix comprising providing a polysaccharide carrier comprising available hydroxyl groups; and reacting said hydroxyl groups with vinyl sulphonate to provide a sulphonate-functionalized (S-functionalized) cation exchanger. The hydroxyl groups of the carrier may be hydroxyls of the agarose polymer; or alternatively they may be provided on extenders such as polyhydroxyfunctional polymers. In one embodiment, the carrier is made of agarose with improved flow pressure properties. | 10-02-2008 |
20080290028 | Stationary Phase and Column Using Cucurbituril Bonded Silica Gel, and Separation Method of Taxol Using the Column - Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract. | 11-27-2008 |
20080314831 | Composite Materials Comprising Supported Porous Gels - This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth. | 12-25-2008 |
20080314832 | METHOD OF FILTERING - Wastewater, in the form of a colloidal solution containing microparticles, is filtrated using a second filter, having a gel film that is formed by suction on the surface of a first filter. The suction pressure in this process is made extremely weak to maintain the filtration capacity while extending intervals prior to clogging of second filter. Furthermore, the gel that becomes adsorbed onto the surface of second filter can be separated readily from the surface of second filter by stopping the suction and filtration can be continued again thereafter. | 12-25-2008 |
20090008327 | ULTRAPOROUS SOL GEL MONOLITHS - Ultraporous sol gel monoliths and methods for preparing the same are provided, having superior flow characteristics for chromatography and analytical chemistry applications. The methods for forming an ultra porous sol-gel monolith include (a) forming a solution comprising a porogen, a matrix dissolving catalyst and a sol gel precursor; (b) allowing the solution to form a gel; and (c) drying the gel at an elevated temperature. The ultraporous sol gel monoliths are characterized by a porosity of up to about 97%, a BET surface area of at least about 50 m | 01-08-2009 |
20090008328 | Composite Materials Comprising Supported Porous Gels - This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth. | 01-08-2009 |
20090008329 | Separating agent for enantiomeric isomers - Provided is a separating agent for enantiomeric isomers that is advantageous from the production standpoints of having a high enantiomeric resolution ability inherent in polysaccharide derivatives, solvent resistance, high solubility in a reaction solvent, and good filtration property. That is, the separating agent for enantiomeric isomers includes a polysaccharide oligomer derivative derived from a polysaccharide oligomer having a number-average degree of polymerization of from 5 to less than 50, supported on a carrier. | 01-08-2009 |
20090020476 | Automated simultaneous separation system for radionuclides in multiple samples and a method for automatically separating uranium (u) using the same - Disclosed herein are an automated simultaneous separation system for radionuclides in multiple samples and a method for automatically separating uranium (U) using the same, which can automatically and simultaneously separate multiple samples. The automated simultaneous separation system includes: a solution distributor( | 01-22-2009 |
20090032461 | METHOD FOR SEPARATING POLYMER SYSTEMS AND PORE-FREE POLYMER FILMS USED IN SAID METHOD - The subject matter of the invention is an innovative method for the separation of polymer systems regarding their molecular weight, chemical structure, chain architecture, and colloidal additives. Such separations are currently accomplished by selective precipitation from solution, by a fractionated crystallization also from solution, and by means of gel chromatographic methods. | 02-05-2009 |
20090032462 | METHOD FOR THE EXTRACTION OF COMPONENTS MADE FROM ORGANIC MATERIAL - The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture. | 02-05-2009 |
20090032463 | COMPOSITE MATERIALS COMPRISING SUPPORTED POROUS GELS - This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth. | 02-05-2009 |
20090039018 | SUSPENSION HOMOPOLYMERIZATION OF AN ISOCYANURATES - Compositions comprising a cross-linked isocyanurate homopolymer or other cross-linked triazine homopolymers in the form of a microbead that is porous or non-porous; methods of making; and methods of using the compositions are disclosed. | 02-12-2009 |
20090078649 | METHOD FOR SELECTIVE REMOVAL OF CADMIUM - A method for selective removal of cadmium from a feed solution also containing other metals such as nickel (Ni) and/or cobalt (Co), utilizing a thiourea based ion exchange resin, and a method for eluting cadmium adsorbed on the thiourea based resin. | 03-26-2009 |
20090095676 | Carrier for Liquid Chromatography, Chromatographic Columns Packed With the Carrier, and Method of Separation of Organic Substances With the Columns - The present invention provides a chromatography carrier which can recover aromatic compounds such as PCB and polycyclic aromatic hydrocarbon from other substances specifically and quickly using small amounts of the carrier and an organic solvent, a chromatography column packed with the carrier and a method for efficiently separating organic compounds such as PCB and polycyclic aromatic hydrocarbon using the column. | 04-16-2009 |
20090095677 | APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND - Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material. | 04-16-2009 |
20090200232 | Process for absorption-based separation of bioparticles from an aqueous suspension - A process for adsorption-based separation of bioparticles from an aqueous suspension containing such bioparticles is disclosed which process comprises | 08-13-2009 |
20090206034 | MODIFIED SILICA GEL AND USE THEREOF - A modified silica gel, in which a surface of a silica gel is partially or entirely coated with a polymer or a copolymer of at least one alkyldisilane compound selected from the group consisting of:
| 08-20-2009 |
20090223893 | Method and Device for Desalting an Analyte - The invention provides gel filtration columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of gel filtration media positioned above a bottom frit or between a bottom and top frit. In some embodiments, the columns employ modified pipette tips as column bodies. In some embodiments, the invention provides methods and devices for desalting and/or buffer exchange of a sample. | 09-10-2009 |
20090321353 | Method and device for extracting bitterness from beer - A method for liquid-liquid extraction comprises introducing a first liquid into a container ( | 12-31-2009 |
20100006501 | METHOD FOR SEPARATION - The invention relates to a method for separation of elements from a fluid using affinity-bearing particles suspended in the fluid and using ultrasonic standing waves and micro-fluidics. The method includes the steps of: mixing said fluid mixture with particles ( | 01-14-2010 |
20100012584 | METHOD FOR ENRICHING ONE OR MORE COMPOUNDS OF A MIXTURE USING A LIQUID MOBILE PHASE CONTAINING A GAS - The object of the invention is a method for enriching by chromatography of one or more compounds of a mixture in at least one column using an eluent, characterized in that a liquid mobile phase containing dissolved gas is used as eluent. A further object of the invention in the use in preparative chromatography of an eluent composed of a liquid mobile phase containing a dissolved gas. | 01-21-2010 |
20100018920 | REACTION AND SEPARATION METHODS - A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. Preferably, the separation technique is based upon difference in the fluorous nature of the first tagged compound and the second tagged compound, differences in total charge between the first tagged compound and the second tagged compound, differences in size between the first tagged compound and the second tagged compound, and/or differences in polarity between the first tagged compound and the second tagged compound. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties. | 01-28-2010 |
20100032372 | USE OF A PRIMARY LIQUID FILTRATION/STABILIZATION INSTALLATION FOR TRIPLE PURPOSE - The present invention relates to a primary liquid filtration/stabilization installation comprising in combination, a liquid in-feed line, a conventional dosing tank system for single use filter-aid and/or stabilization-aid, and an alternate dosing/storage tank system for regenerable filter-aid and/or stabilization-aid, wherein the installation is adapted to selectively operate one or the other of the dosing systems to meter doses of their respective charges into liquid that is delivered through the in-feed line, and a filter adapted to retain filter-aid material thereon, while passing liquid from which retained material has been removed. | 02-11-2010 |
20100038313 | METHOD FOR PURIFYING SIALYLLACTOSE BY CHROMATOGRAPHY - The application relates to a method for purifying sialyllactose by ion-exclusion chromatography of a solution containing the sialyllactose on a mainly manovalent strong cationic resin, Na or K, and obtaining a sialyllactose-enriched raffinate. | 02-18-2010 |
20100044308 | OPEN-CELL FOAM MODIFIED WITH HYDROPHOBINES - Open-cell foam based on a melamine-formaldehyde condensation product, a polyurethane or a polyimide, which has been modified with hydrophobins, a method of producing such foams, and the use thereof for absorbing organic liquids, as leakage and bleeding protection for liquid stores, for liquid-liquid separation and as matrix for carrying out chemical and/or biological processes. | 02-25-2010 |
20100065495 | APPARATUS AND METHODS FOR PREPARATIVE LIQUID CHROMATOGRAPHY - A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit. The control unit includes a processor and a memory that stores instructions; the control unit controls proportioning of solvents to obtain a preselected solvent composition, and pumping at flow rates to support preparative-scale or process-scale liquid chromatography. | 03-18-2010 |
20100078382 | CONTINUOUS COLLECTION METHOD OF PARTICLE COMPONENT IN AQUEOUS SOLUTION AND APPARATUS THEREFOR - The particle components may be collected by using a phenomenon that the particle components in the aqueous phase aggregate at the liquid-to-liquid interface. Both of the particle components and the dissolved components in the aqueous phase may be simultaneously collected if combined with liquid-liquid extraction phenomenon that the dissolved components in the aqueous phase are collected into the solvent phase through the liquid-to-liquid interface. The aggregation phenomenon of the particle components at the liquid-to-liquid interface may be promoted by using an emulsion flow method, a method of applying mechanical external forces (such as stirring and vibrating) or another method combining both the above-mentioned methods. | 04-01-2010 |
20100101996 | BORON-REMOVING AGENT AND BORON REMOVAL METHOD UTILIZING XEROGEL - Disclosed is a boron removal method which can remove boron from boron-containing water satisfactorily by using a small amount of a chemical agent, and which generates small amount of precipitate. Also disclosed is a boron-removing agent which is easy to handle and has excellent boron-adsorption ability. A xerogel of an organic polymeric compound having a cis-type diol structure and a water-soluble salt of an alkaline earth metal are added to a boron-containing water under alkaline conditions. | 04-29-2010 |
20100193434 | COUNTERCURRENT TANGENTIAL CHROMATOGRAPHY METHODS, SYSTEMS, AND APPARATUS - This invention relates to a breakthrough in the art of chromatography allowing 1) larger scale of operation; 2) faster processing time; 3) disposability; 4) reduction of media/resin expenses; and 5) a reduction of capital equipment investment. In this invention, the chromatography column is replaced by a module that consists of two or more interconnected tangential flow filters and static mixers. The chromatography resin flows through this module in a single pass, while similar operations to a regular chromatographic process are performed on the resin (binding, washing, elution, regeneration, and equilibration). The buffers for these operations are pumped into the module in a countercurrent direction to the flow of resin, and permeate solutions from later stages are recycled back into previous stages. This creates concentration gradients in the permeate solutions of the tangential flow filters in the countercurrent direction to resin flow, thus saving buffer volume and increasing process efficiency. | 08-05-2010 |
20100219127 | Control system and method for flash separation - Provided are methods and apparatus for determining conditions for performing chromatography, particularly flash chromatography. The methods may be utilized for separating compounds in a sample in a column chromatography system. The method includes determining at least two retention factors corresponding to the TLC performance of a target compound and an adjacent compound and defining a sample loading amount and a solvent gradient profile using at least two solvents that will result in differential elution of the target and adjacent compounds from a chromatography column. The chromatography system and loading parameters may be selected to provide satisfactory separation of the target compound from adjacent compounds. | 09-02-2010 |
20100288699 | PURIFICATION OF WATER FROM COOLING TOWERS AND OTHER HEAT EXCHANGE SYSTEMS - The amount of silica in cooling tower water is reduced by passing cooling tower water through a column of silica gel. | 11-18-2010 |
20100294716 | Templated Native Silk Smectic Gels - One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method. | 11-25-2010 |
20100307972 | SELECTIVE SULPHATE REMOVAL BY EXCLUSIVE ANION EXCHANGE FROM HARD WATER WASTE STREAMS - The invention provides waste water treatment processes utilizing an ion exchange resin to remove sulphate anions, while adjusting the pH of the ion exchange loading solution with carbon dioxide gas. The effect of the resin loading reactions is that dissolved sulphate is replaced with sequestered carbon dioxide gas, in the form of dissolved bicarbonate, in the treated water and the cations are not removed from the solution. | 12-09-2010 |
20100326909 | MANIPULATION OF MAGNETIC MICROPARTICLES IN A HIGH PRESSURE LIQUID SYSTEM AND EXTRACTION PROCESS - Described are a device and a method for the manipulation of a liquid sample material in which magnetic microparticles are suspended whereby the microparticles have a functionalized surface and an analyte is bound to the surface. The sample material is introduced into a device with a liquid system through an injection device ( | 12-30-2010 |
20110042310 | METHOD AND DEVICE FOR CHROMATOGRAPHIC PURIFICATION - A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent(s). The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (α,β,γ,δ). After or within a switch time (t*) the last column from the first section (α) is moved to the first position of the second section (β), the last column of the second section (β) is moved to the first position of the third section (γ), the last column of the third section (γ) is moved to the first position of the fourth section (δ) and the last column of the fourth section (δ) is moved to become the first column of the first section (α). | 02-24-2011 |
20110186511 | LIQUID CHROMATOGRAPHY APPARATUS AND LIQUID CHROMATOGRAPHY - A liquid chromatography apparatus is provided with a sample preparation unit, a column that separates components of a sample, an eluent supplier that includes a feeder for supplying eluents to the column, a flow path directional valve capable of introducing fixed amounts of the sample and the eluents to the column, an analyzer for analyzing a test solution composed of the sample components separated by the column and one of the eluents, and a controller, wherein the eluent supplier supplies the eluents to the flow path directional valve in an unmixed state. As a result of employing this configuration, analysis time is shortened and eluent consumption is reduced. | 08-04-2011 |
20120000850 | SOL-GEL MONOLITHIC COLUMN WITH OPTICAL WINDOW AND METHOD OF MAKING - A method of preparing a sol-gel monolithic column includes the step of forming a separation bed ( | 01-05-2012 |
20120037564 | METHODS AND SYSTEMS FOR REDUCING VIRAL LOAD OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS - The present technology relates to methods and systems for the removal of pathogens and fragments thereof in hemodialysis patients. In particular, methods and systems are described where lectins can be used to remove the Hepatitis C virus and fragments thereof in hemodialysis patients, and to provide a sustained reduction in viral load. | 02-16-2012 |
20120125843 | METHODS AND MATERIALS FOR PERFORMING HYDROPHOBIC INTERACTION CHROMATOGRAPHY - A method for performing hydrophobic interaction chromatography includes providing at least one wall defining a chamber having an inlet and an exit, and a stationary phase disposed within the chamber. The stationary phase comprises particles or monolith having a hydrophobic surface and a hydrophilic ligand. The method also includes loading a sample onto the stationary phase in the chamber and flowing the sample over the stationary phase. The sample is separated into one or more compositions by hydrophobic interaction between the stationary phase and the one or more compositions. | 05-24-2012 |
20120125844 | REMOVAL OF ORGANIC DYES AND ORGANIC POLLUTANTS BY TITANIUM PEROXIDE GEL - The one step process of removal of chromophore/dye/organic pollutant from a solution comprising a polymer free titanium oxide gel i.e. high zeta potential is disclosed. The concentration of the chromophores is removed up to 95-100%. | 05-24-2012 |
20130213884 | CHROMATOGRAPHY SYSTEM WITH GUARD COLUMNS - A chromatography system with a main column comprising a chromatography resin, a first guard column and a second guard column, wherein the first guard column is connected to a first end of the main column, the second guard column is connected to a second end of the main column and the bed volumes of said first and second guard columns are each less than about 50% of the bed volume of the main column. | 08-22-2013 |
20130228513 | GRADIENT SEPARATION METHOD TRANSFER FOR LIQUID CHROMATOGRAPHY SYSTEMS - Described is a method of transferring a gradient separation method to a liquid chromatography system. A value of a delivered gradient slope for a gradient separation method performed on a first liquid chromatography system is determined based on a value of a programmed gradient slope for the gradient separation method and a predetermined relationship between delivered gradient slope and programmed gradient slope for the first liquid chromatography system. The gradient separation method is performed on a second liquid chromatography system using a delivered gradient slope having a value equal to the value of the delivered gradient slope determined for the first liquid chromatography system | 09-05-2013 |
20130277303 | SUB-2 MICRON CHIRAL STATIONARY PHASE SEPARATION AGENT - The present invention relates to a porous sub-2 chiral stationary phase agent that provides stability and increased productivity for chiral separation using HPLC and UHPLC methods. It was surprisingly discovered that highly stable and backpressure resistant coated and at least partially covalently bonded chiral stationary phase agents having an average particle diameter less than 2 microns can be obtained by maintaining a pore ratio of from 0.0042 to about 0.010. | 10-24-2013 |
20130277304 | SUB-2 MICRON CHIRAL STATIONARY PHASE SEPARATION AGENTS FOR USE WITH SUPERCRITICAL FLUID CHROMATOGRAPHY - The present invention relates to chiral separation column for use with supercritical fluid chromatography (SFC) containing a porous sub-2 chiral stationary phase agent that offered significant savings in run times and solvent use over the more conventional chiral columns using SFC methods. It was surprisingly discovered that SFC columns containing highly stable and backpressure resistant sub-2 micron stationary phase agents which were either coated or at least partially covalently bonded with polysaccharide or derivatized polysaccharide and which have an average particle diameter less than 2 microns can be obtained by maintaining a pore ratio of from 0.0042 to about 0.010 provide improved efficiency. | 10-24-2013 |
20130306558 | METHOD AND APPARATUS FOR REACTION CHROMATOGRAPHY - An apparatus for reaction chromatography comprising: a chromatography column, the column having a fluid outlet for an eluate flow, wherein the fluid outlet is configured with two or more fluid ports, the two or more fluid ports comprising one or more reactant ports, wherein each reactant port is for connecting a reactant flow into the eluate flow to react with the eluate flow, and one or more product ports for receiving the reacted eluate flow; one or more reactant sources in fluid communication with the one or more reactant ports to provide the reactant flow; and one or more processing units in fluid communication with the one or more product ports to process the reacted eluate flow. | 11-21-2013 |
20140048481 | INTEGRATED CHROMATOGRAPHY DEVICES AND SYSTEMS FOR MONITORING ANALYTES IN REAL TIME AND METHODS FOR MANUFACTURING THE SAME - Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process. | 02-20-2014 |
20140061128 | MOBILE PHASE PREPARATION DEVICE FOR LIQUID CHROMATOGRAPHY - A mobile phase delivery device for use with high pressure liquid chromatography includes a manifold having a plurality of inlets, wherein each inlet is fluidly coupled with a solvent source. The manifold further has a mobile phase outlet that outputs a mobile phase, composed of solvent or solvent mixture, onto an analytical line. The device further includes at least one pump for delivering solvent to the manifold, and a fluid branch in the manifold that is located at a point downstream of the plurality of inlets, and is fluidly coupled with at least one of a pressure sensor and a purge valve. | 03-06-2014 |
20140091036 | Countercurrent Chromatography Rotor - A method for constructing a spiral tube support apparatus used in countercurrent chromatography, improvements to countercurrent chromatography tube support design, and methods of using the improved countercurrent chromatography apparatus are described. The spiral tube support apparatus may be constructed by a shape forming process such as a three dimensional printing process that in turn uses a laser sintering technique, and can be made out of any easily formed material. Shape changes on both the tube support and the top improve the performance of the tube support and ease of manufacturing. The improved tube support and new method of creation permit use in both micro or macro scale preparations and use in small or large molecule preparations. In particular, specific solvent systems are described that permit purification of proteins. | 04-03-2014 |
20140116940 | REMOVAL OF ELEMENTS FROM AQUEOUS FLUIDS - Methods of removing ions from an aqueous fluid can comprise increasing the pH of the aqueous fluid and contacting the aqueous fluid with anion exchange materials. | 05-01-2014 |
20140116941 | METHOD FOR REMOVING BIOPOLYMER AGGREGATES AND VIRUSES FROM A FLUID - The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body having a native surface. In a second step, the biopolymer aggregate-free fluid is filtered through at least one suitable virus-retentive membrane. | 05-01-2014 |
20140131276 | DEVICE AND METHOD FOR RESTORATION OF THE CONDITION OF BLOOD - The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood com-Components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate. | 05-15-2014 |
20140131277 | Closed Loop Flow Control Of A HPLC Constant Flow Pump To Enable Low-Flow Operation - A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<1 μL/min) HPLC flow rates. | 05-15-2014 |
20140138312 | Reducing Dispersion Due To Vias In Planar Microfluidic Separation Devices - A planar microfluidic chemical separation device includes a separation channel that is located in the plane of the device. The device also includes one or more vias situated perpendicular to the separation channel. The vias extends between the separation channel and an outer surface of the substrate for fluid communication with the separation channel. The vias have cross-sectional areas that are substantially less than a cross-sectional area of a first region of the separation channel to inhibit band-broadening caused by passage of a sample band through the one or more vias. | 05-22-2014 |
20140158615 | PREFILLED LIQUID CARTRIDGE FOR THE SUPPLY OF A SAMPLE SEPARATION DEVICE WITH AN OPERATING LIQUID - Prefilled liquid cartridge for fluidically connecting to a sample separation device for separating of components of a fluidic sample by using liquid of the liquid cartridge, wherein the liquid cartridge comprises a liquid container which is prefilled with liquid and a liquid removal access provided at the liquid container, adapted to be fluidically coupled with at least one liquid conduit of the sample separation device by only inserting the liquid cartridge in a corresponding liquid cartridge accommodation of the sample separation device. | 06-12-2014 |
20140238935 | Mixed-Mode Chromatography Membranes - Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion. | 08-28-2014 |
20140299542 | Method and System for Liquid Chromatography Fluidic Monitoring - A method for monitoring a fluidic system of a liquid chromatography system is characterized by: (a) drawing a fluid into a syringe pump; (b) configuring a valve so as to fluidically couple the pump to either a fluidic pathway through the fluidic system or to a plug that prevents fluid flow; (c) causing the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determining a profile of the variation of the measured pressure; (e) comparing the determined profile to an expected profile that depends upon the fluid; and (f) providing a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance. | 10-09-2014 |
20140311977 | USE OF ORGANIC SOLVENT NANOFILTRATION AND LIQUID-LIQUID CHROMATOGRAPHY FOR THE RECOVERY OF PHARMACEUTICAL PRODUCTS - A process for separating a compound from solution in organic solvent by a chromatographic process, in particular liquid-liquid chromatography, in which prior to the chromatographic process the composition of the solution is changed by means of a process of organic solvent nanofiltration for a solvent exchange. Additionally or alternatively subsequent to the chromatographic process the output from the chromatographic process is subjected to a process of organic solvent nanofiltration to remove residual target compound and/or impurities in the output for solvent recovery. | 10-23-2014 |
20140326664 | SELECT VALVE FOR LIQUID CHROMATOGRAPHY - A liquid chromatography system includes a pumping system with a selector valve in fluidic communication with a pump inlet. The selector valve switches between a first position, in which the selector valve fluidically couples a solvent reservoir to the pump inlet, and a second position, in which the selector valve fluidically couples a pressurized source of liquefied carbon dioxide (for example) to the pump inlet. The liquid chromatography system can perform as a HPLC system (or as an UPLC system) when the selector valve is in the first position and as a CO | 11-06-2014 |
20140374350 | METHOD FOR REMOVING IONIC SPECIES CONTAINED IN AN AQUEOUS PHASE USING A SOL GEL COMPOSITE MATERIAL - Disclosed is a method for removing an ionic species contained in an aqueous phase. The method includes contacting an aqueous phase containing the ionic species with a sol-gel composite material, where the sol-gel composite material is a sol-gel composition having a porous matrix and containing a reactive metal incorporated into at least a portion of the porous matrix, under conditions sufficient to remove the ionic species contained in the aqueous phase. | 12-25-2014 |
20150021265 | FLOW SPLITTING IN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS - A method includes passing a mobile phase fluid flow comprising liquefied CO2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow. | 01-22-2015 |
20150076062 | HYDROGEL-BASED DECONTAMINATION OF AQUEOUS SAMPLES CONTAINING NANOPARTICLES - The present invention relates to the use of a supramolecular system in order to remove particles from a liquid medium containing same. According to the invention, the supramolecular system includes at least one molecule having a low molecular weight and/or an organic compound from living organisms, preferably from jellyfish, said compound being selected from among collagen, a polysaccharide, a proteoglycan or a mixture of two of said organic compounds, and said molecule having a low molecular weight and formula (I) as defined herein. The invention also relates to a method for removing particles from a liquid medium containing same. The invention is particularly suitable for use in water decontamination and biotechnology. | 03-19-2015 |
20150129494 | METHOD AND AN APPARATUS FOR CONTROLLING FLUID FLOWING THROUGH A CHROMATOGRAPHIC SYSTEM - A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid. | 05-14-2015 |
20220137011 | ANALYSIS SYSTEM AND ANALYSIS EXECUTION METHOD - An analysis system is used to together with a sample supplier that supplies a sample, a detector that detects a sample and a display, and includes a plurality of channels arranged in parallel with one another and a display controller that causes a display to display a control screen in regard to control of the plurality of channels. Each channel includes a mobile phase supplier that supplies a mobile phase and an analysis column that separates a sample that has been supplied by the sample supplier into components and guides the components to the detector. | 05-05-2022 |