Entries |
Document | Title | Date |
20080217171 | BIOSENSOR - A biosensor that is capable of measuring a material contained in a sample is provided. The biosensor is configured to be inserted into a display device, and measures a material contained in the sample. The biosensor includes i) first and second substrates that are opposed to each other; ii) a sample guiding layer that has two sample injection openings and is located on the first substrate; iii) a first electrode that is located between the first substrate and the sample guiding layer; iv) a second electrode that is located between the second substrate and the sample guiding layer; v) a third electrode that is located between the sample guiding layer and the second substrate; and vi) a penetrated opening that penetrates the first substrate, the sample guiding layer, and the second substrate. The second electrode is spaced apart from the first electrode. The biosensor further includes i) a long edge, and ii) a short edge that shares a corner of the biosensor and neighbors the long edge. Each of the two sample injection openings is formed to correspond to the long edge and the short edge, respectively. | 09-11-2008 |
20080230384 | LOW VOLUME ELECTROCHEMICAL BIOSENSOR - A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode, into the conductive track leading from the working electrode to an electrical contact associated with the working electrode, and/or into the electrical contact associated with the working electrode. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode. | 09-25-2008 |
20080237041 | ANALYTE EVALUATION APPARATUS - This analyte evaluation apparatus has an analyte space for holding a liquid containing an analyte, a working electrode, a counter electrode and a reference electrode, and the potential of the working electrode is altered with respect to the potential of the reference electrode as the standard potential, and the behavior of the analyte is observed to thereby evaluate the analyte, and the working electrode is provided in the analyte space and the counter electrode and reference electrode are provided in an electrode medium container for holding an electrically conductive electrode medium while being connected via an electrically conductive communicating part for substantially blocking the passage of liquid from the analyte space. | 10-02-2008 |
20080257728 | Biosensor - A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in the peripheral part and partially closed by the adhesive layer, and has a working electrode having at least glucose oxidase immobilized thereon and a counter electrode on the same plane of the plate. | 10-23-2008 |
20080264787 | ELECTROCHEMICAL CELL - An electrochemical cell for detection and quantification of analytes in a liquid sample, particularly a liquid sample having a small volume. In a preferred embodiment, the electrochemical cell comprises an assembly of conducting layers and insulating layers. The electrochemical cell can be formed by depositing conducting materials and insulating materials in alternating layers on an insulating substrate. It is preferred that the layer furthest from the insulating substrate be an insulating layer to minimize the damage of the conducting layers during handling of the electrochemical cell. In another embodiment, the assembly of conducting layers and insulating layers can be formed on both major surfaces of the insulating substrate. The assembly can comprise at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode. | 10-30-2008 |
20080277278 | BIOSENSOR FOR DISEASE DIAGNOSIS - The present invention relates to a biosensor including: a bottom plate having a base film having a lead mounted at one side of the top surface thereof, an electrode member formed on the base film, a spacer formed on the top surface of the electrode member so as to secure a recess having a predetermined width formed on the electrode member, and an enzyme reaction layer formed transversely on the top surface of the electrode member in such a fashion as to be positioned in the recess of the spacer; and a top plate formed integrally with the bottom plate and having the same configuration as the bottom plate. | 11-13-2008 |
20080308419 | Chip for electrochemical immunoassay - The present invention provides a chip | 12-18-2008 |
20090000947 | Biosensor and Biosensor Cell - A biosensor includes a supporting layer, a reference electrode layer, a working electrode layer, a counter electrode layer, and a temperature detection device, which are formed on a front surface of the supporting layer, an enzyme film that coats a surface of the working electrode layer, and a heater member formed on a back surface of the supporting layer. A biosensor cell includes a sample chamber to which a sample solution flows in and out, and the above-described biosensor. | 01-01-2009 |
20090008247 | Composite Modified Electrode Strip - The present invention provides a surface-modified electrode strip for measuring an electrochemical signal that is synergistically amplified by means of a nano-scaled gold particle layer and a lipid-soluble electron mediator layer. A biosensor comprising the electrode strip is also provided. | 01-08-2009 |
20090008248 | Enzyme Electrode and Enzyme Sensor - Disclosed is an enzyme electrode comprising: an electrode; a carbon nanotube layer including a plurality of carbon nanotubes extending directly from the electrode and/or a metallic catalyst immobilized on the electrode; and an enzyme immobilized in the carbon nanotube layer by being sandwiched between the carbon nanotubes. | 01-08-2009 |
20090020420 | Biosensor Chip and Biosensor Chip Production Method - It is intended to provide a biosensor chip capable of rapid and correct measurement, including a reaction chamber that enables a measurement of a very small amount of a measurement sample and has a small capacity and potassium ferricyanide having a very small crystal particle size disposed in the reaction chamber. | 01-22-2009 |
20090026075 | Electrochemical Analyte Detection Apparatus and Method - A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry, in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes. | 01-29-2009 |
20090032395 | Biosensor - A biosensor is a sensor strip that is folded to form a base and a cover. The base has sides, a reactive layer and two electrodes. The reactive layer is mounted of the base and has a gap. The electrodes are mounted longitudinally on the base respectively near the sides and connect to the reactive layer. The cover bonds to and is shorter than the base and has a sample notch formed in one side of the cover, corresponding to the reactive layer and being near one of the electrodes. Because the sample notch is formed in the side of the cover and blood needs to cross the gap, blood reacts thoroughly with the reactive layer to provide accurate test results. | 02-05-2009 |
20090045056 | Stable three enzyme creatinine biosensor - The invention provides methods for preparing a stable, multiple-use three enzyme biosensor for the amperometric determination of creatinine in biological liquids that has a useful lifetime that extends significantly beyond that of presently available amperometric biosensors. The biosensor prepared by the methods of the invention encompasses a plurality of immobilized enzymes that are applied to the biosensor as an enzyme-polymer composition. The enzymes, which can include creatinine amidohydrolase, creatine amidinohydrolase and sarcosine oxidase, are immobilized into the enzyme-polymer composition simultaneously as well as applied to the biosensor simultaneously. Prior to being immobilized, the enzymes can be chemically modified by attaching one or more polyethylene glycol (PEG) chains per enzyme monomer. The polymer component can be provided by a polyurethane membrane. The invention also provides a method of preparing a biosensor that limits the diffusion of silver ions emanating the reference electrode, thereby preventing, contact between the silver ions and the enzymes. Related methods of preparing an enzyme-polymer composition for incorporation into a multiple use three enzyme biosensor for the amperometric determination of creatinine in biological liquids also are provided. The invention also provides multiple-use biosensors and enzyme-polymer compositions prepared by the methods disclosed. | 02-19-2009 |
20090065356 | BIOSENSOR - In a biosensor for measuring glucose in a liquid sample, an additive agent which is one of an organic acid or organic acid salt having at least one carboxyl group in a molecule, an organic acid or organic acid salt having at least one amino group or carbonyl group in a molecule, a sugar alcohol, and a solubilized protein, or a combination thereof is added into a reagent layer including glucose dehydrogenase having flavin adenine dinucleotide as a coenzyme, which is provided on an insulating substrate. Thereby, the substrate specificity to glucose and the preservation stability can be enhanced, and further, reactions to sugars other than glucose can be avoided. | 03-12-2009 |
20090084678 | NANOELECTRONIC ELECTROCHEMICAL TEST DEVICE - Nanoelectronic devices for the detection and quantification of biomolecules are Provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules. | 04-02-2009 |
20090090624 | BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS - The present invention is based on the discovery of NAD | 04-09-2009 |
20090090625 | BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS - The present invention is based on the discovery of NAD | 04-09-2009 |
20090095625 | Mediator-Stabilized Reagent Compositions for Use in Biosensor Electrodes - The claimed subject matter relates to the stabilization of 1,2-quinone mediators, especially those containing 1,10-phenanthroline quinone (PQ) and more especially transition metal complexes of PQ, in the presence of enzymes when contained in dry reagent layers for biosensor electrodes, through the use of various metal salts, particularly those of lithium. | 04-16-2009 |
20090101499 | Protein-Immobilized membrane, method for immobilization of protein, enzyme-immobilized electrode, and biosensor - The present invention relates to a protein-immobilized membrane ( | 04-23-2009 |
20090134023 | BIOSENSOR - In a biosensor of the present invention, BSA is contained in a reagent layer including a reagent which reacts specifically with glucose, and the glucose concentration in whole blood as a sample solution is electrochemically measured. When the sensor response characteristics when whole blood is used as the sample solution are measured, the influence by hematocrit to the sensor response characteristics is reduced according to the additive amount of BSA when the hematocrit value is in the range of 25% and below, while no BSA addition effect is recognized in the sensor response characteristics when the hematocrit value is in the range of 25 to 65%. Thereby, the influences by hematocrit and temperature can be reduced, and thus highly precise measurement can be performed. | 05-28-2009 |
20090145755 | Wear-resistant electrochemical test sensor and method of forming the same - An electrochemical test sensor includes a base, a generally hard electrically-conductive layer, an electrochemically-active layer, and a lid. The electrically-conductive layer is located between the base and the electrochemically-active layer. The electrically-conductive layer and the electrochemically-active layer are made of a different material. The electrically-conductive layer and the electrochemically-active layer form an electrode pattern. The electrochemical test sensor includes a reagent adapted to assist in determining information related to an analyte of a fluid sample. | 06-11-2009 |
20090145756 | Method of depositing reagent material in a test sensor - A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern. | 06-11-2009 |
20090145757 | Redox Polymers - Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described. | 06-11-2009 |
20090152111 | Biosensor, thin film electrode forming method, quantification apparatus, and quantificaion method - A biosensor according to the present invention comprises a support | 06-18-2009 |
20090194416 | Potentiometric biosensor for detection of creatinine and forming method thereof - The present invention discloses a potentiometric biosensor for detecting creatinine, and the forming method thereof. The disclosed biosensor comprises a substrate, a working electrode formed on the substrate, a first reference electrode formed on the substrate, a second reference electrode formed on the substrate, and a packaging structure which separates the above-mentioned three electrodes. The working electrode comprises creatinine iminohydrolase (CIH). The detection signal is transmitted out from the biosensor for further processing through a wire or an exposed surface. The disclosed biosensor is replaceable. | 08-06-2009 |
20090211905 | ELECTROCHEMICAL CELL - An electrochemical cell for detection and quantification of analytes in a liquid sample, particularly a liquid sample having a small volume. In a preferred embodiment, the electrochemical cell comprises an assembly of conducting layers and insulating layers. The electrochemical cell can be formed by depositing conducting materials and insulating materials in alternating layers on an insulating substrate. It is preferred that the layer furthest from the insulating substrate be an insulating layer to minimize the damage of the conducting layers during handling of the electrochemical cell. A passage can be formed through the conducting layers and the insulating layers to expose the edges of the layers, which collectively form the wall or walls of the passage. The exposed edges of the conducting layers form the electrodes of the electrochemical cell. The electrochemical cell comprises at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode. In another embodiment, the assembly of conducting layers and insulating layers can be formed on both major surfaces of the insulating substrate. The assembly can comprise at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode. | 08-27-2009 |
20090236222 | BIOSENSOR - It is an object of the present invention to provide a sensor, which is capable of measuring, quickly and in high accuracy, concentration of neutral fat from a sample such as a biological sample or the like, without executing pretreatment of the sample. This object is attained by a biosensor for measuring concentration of neutral fat, based on value of current flowing in the electrode system, having: an insulating substrate; an electrode system having a working electrode and a counter electrode, formed onto the insulating substrate; and a reaction layer having a lipoprotein lipase, a glycerol dehydrogenase and an electron mediator, formed at the upper part or the vicinity of the electrode system. | 09-24-2009 |
20090250343 | Tyrosinase enzyme electrode and production method thereof - Disclosed are a tyrosinase enzyme electrode containing metal nanoparticles and its producing method. Metal nanoparticles are applied to a surface of a support with high chemical stability. Also, a buffer layer consisting of a self-assembled monolayer is formed on the metal nanoparticles. Such self-assembled monolayer is used to immobilize tyrosinase enzyme which was subsequently prepared. In other words, the self-assembled monolayer is arranged between the metal nanoparticles and the tyrosinase enzyme so as to immobilize the tyrosinase enzyme on the support. Introduction of the metal nanoparticles into the electrode contributes to improvement in detection limits of the tyrosinase enzyme electrode. In addition, the introduction of substrate induces the activation of enzyme. | 10-08-2009 |
20090255811 | BIOSENSOR COATING COMPOSITION AND METHODS THEREOF - The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode. | 10-15-2009 |
20090321256 | BIOSENSORS AND METHODS OF MAKING - Devices and methods for determining the concentration of an analyte in a sample of liquid are provided. | 12-31-2009 |
20090321257 | BIOSENSOR, METHOD OF PRODUCING THE SAME AND DETECTION SYSTEM COMPRISING THE SAME - A biosensor that detects a target substance contained in a liquid sample has an insulating base plate including a recess formed in a portion that is thinner than the surrounding part, a working electrode and a counter electrode, at least one of which is disposed in the recess, and a reaction reagent that is disposed in the recess and reacts with a specific substance in the liquid sample. | 12-31-2009 |
20100006432 | Biosensor - In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration. | 01-14-2010 |
20100038242 | TRANSITION METAL COMPLEXES WITH (PYRIDYL)IMIDAZOLE LIGANDS - Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described. | 02-18-2010 |
20100059370 | Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. | 03-11-2010 |
20100059371 | Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. | 03-11-2010 |
20100059372 | Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. | 03-11-2010 |
20100059373 | Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. | 03-11-2010 |
20100072063 | Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. | 03-25-2010 |
20100072064 | Subcutaneous Glucose Electrode - A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible. | 03-25-2010 |
20100078322 | BIOSENSOR - It is an object of the present invention to provide an excellent biosensor which can perform supply of a sample solution accurately and easily. A biosensor which has a capillary ( | 04-01-2010 |
20100084268 | LOW VOLUME ELECTROCHEMICAL BIOSENSOR - A biosensor in which at least one reagent constitutes a portion of a working electrode, a conductive track leading from a working electrode to an electrical contact associated with a working electrode, or an electrical contact associated with a working electrode. For example, the biosensor can have a mediator or an enzyme or both incorporated into the working electrode itself. Other reagents can be dispensed on the electrode itself either directly or by impregnating a matrix, such as a mesh or a membrane, with the enzyme, and then placing the impregnated mesh or membrane over the electrode. Alternatively, the biosensor can have a mediator or an enzyme or both incorporated into the conductive track leading from the working electrode to an electrical contact associated with the working electrode. In another alternative, the biosensor can have a mediator or an enzyme or both incorporated into the electrical contact associated with the working electrode itself. Furthermore, the biosensor can have a mediator or an enzyme or both incorporated into at least two of the foregoing components of the biosensor. | 04-08-2010 |
20100108509 | Analyte Sensor with Non-Working Electrode Layer - Disclosed is an electrochemical sensors for measuring an analyte in a subject. More particularly, the sensor comprises a non-working electrode, the non-working electrode comprising a non-working electroactive surface, and a layer covering at least a portion of the non-working electroactive surface, the layer configured to prevent or reduce endogenous or exogenous components from contacting the non-working electrode surface. | 05-06-2010 |
20100126857 | ANALYSIS INSTRUMENT - An analysis instrument for processing a microfluidic device, having sample storage means, a microfluidic device holder, sample loading means for loading sample into a microfluidic device disposed in the holder, processing means for enabling a reaction in a microfluidic device, and detection means for detecting and/or measuring the reaction is disclosed. The microfluidic device holder is adapted to hold the microfluidic device including a tape in position for processing and/or detection. A microfluidic processing device is also disclosed which includes a reaction chamber, and a sample loading chamber into which a sample is injectable. The reaction chamber is operatively connected to the sample loading chamber. A cover extends across at least part of the sample loading chamber. The cover and the reaction chamber include pierceable material and are separated by an overspill cavity configured to accept any overspill of an injected sample. A kit is also disclosed which has the analysis instrument and the microfluidic processing device as described above. | 05-27-2010 |
20100126858 | CHEMICAL SENSOR TYPE MEASURING APPARATUS - There is disclosed means for quickly solving instability of sensor sensitivity performances found in an initial stage and stabilizing the sensor sensitivity performances, when immersing a chemical sensor kept under a dry state in a buffer solution used as a storage liquid and applying a measurement bias between a working electrode and a reference electrode to make first use of the chemical sensor for measurement in which the chemical sensor is used. To make the first use of the chemical sensor, after immersing the chemical sensor kept under a dry state in the buffer solution used as the storage liquid, a first initial treatment bias having the same direction as that of the measurement bias and possessing an absolute value larger than that of the measurement bias is applied between the working electrode and the reference electrode for a first initial treatment time. Subsequently, the bias is changed to a second initial treatment bias which is the same as the measurement bias, and the second initial treatment bias is applied for a second initial treatment time. When such a two-step initial treatment operation is carried out, the stabilized sensor sensitivity performance is achieved. | 05-27-2010 |
20100170792 | ELECTROSENSING ANTIBODY-PROBE DETECTION AND MEASUREMENT SENSOR - A sensor for electrosensing an antigen in a test sample is disclosed. The sensor has two electrodes electrically disconnected and physically separated from each other, and a layer of antibody is immobilized on the surface of at least one of the electrodes. The antibody has specific binding reactivity with the antigen. Conductivity promotion molecules may be tethered over and/or distributed between the antibody-populated electrodes for improving electrical conductivity characteristics across the two electrodes. The antibody captures the antigen present in the test sample mixed in a buffer solution that comes into contact with the antibody-populated electrodes. This alters the electrical conductivity characteristic across the two electrodes in which an amount representative of the altering provides an indication for electrosensing of the antigen. | 07-08-2010 |
20100170793 | Small Volume In Vitro Analyte Sensor and Methods of Making - A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent. | 07-08-2010 |
20100175992 | METHODS AND MATERIALS FOR CONTROLLING THE ELECTROCHEMISTRY OF ANALYTE SENSORS - Embodiments of the invention provide electrochemical analyte sensors having elements designed to modulate their electrochemical reactions as well as methods for making and using such sensors. | 07-15-2010 |
20100187107 | Enzyme electrode - The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example. | 07-29-2010 |
20100187108 | GAS-COMPONENT MEASUREMENT DEVICE - A gas-component measurement device includes a housing having an suction port that introduces a measurement-targeted gas, and an exhaust port that discharges the measurement-targeted gas, and a water-absorbing member that is disposed in the housing and impregnated with a solvent that dissolves a gas component, and an electrochemical sensor that detects the gas component trapped by the solvent in the water-absorbing member. The exhaust port and suction port are disposed to oppose each other while sandwiching therebetween the electrochemical sensor. | 07-29-2010 |
20100193355 | NOVEL GLUCOSE DEHYDROGENASE AND METHOD FOR PRODUCING THE DEHYDROGENASE - A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus | 08-05-2010 |
20100213057 | Self-Powered Analyte Sensor - Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 08-26-2010 |
20100213058 | Biosensor Membranes - Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described. | 08-26-2010 |
20100219072 | ENZYME ELECTRODE AND METHOD FOR PRODUCING THE SAME - An enzyme electrode and its producing method are disclosed. The method includes providing a substrate having a carbon surface; forming a gold surface on the carbon surface and forming an electrode; modifying the gold surface by L-cysteine; modifying the gold surface by N,N′-dicyclohexylcarbodiimide; and chemically bonding the modified gold surface with a glucose oxidase. | 09-02-2010 |
20100219073 | BIOLOGICAL TEST CHIP AND A MANUFACTURING METHOD THEREOF - The present invention discloses a biological test chip and a method for manufacturing the same. The biological test chip comprises a test unit and an auxiliary unit for producing capillary action. The test unit includes a baseboard, at least one pair of electrodes and wires connected to the electrodes that are provided on the baseboard by using printed-circuit-board manufacturing process, and a photoresist layer covering the baseboard. The auxiliary unit includes a double-faced adhesive gel layer and a hydrophilic layer that have at least two thin plates respectively. By utilizing the manufacturing process for a printing circuit board and the photoresist layer, body fluid to be tested can be rapidly drawn in to fill the reaction areas formed in the photoresist layer and thereby can react evenly and rapidly with the reactive enzymes used for the test. | 09-02-2010 |
20100224488 | Bilirubin Sensor - A bilirubin sensor has a working electrode with a first chemical matrix disposed thereon that contains a binder, a substrate electrode with a second chemical matrix dispose thereon that contains a binder and a chemical agent that consumes bilirubin, a reference electrode, a sample chamber containing the working electrode, the substrate electrode and the reference electrode, and a method of measuring bilirubin in a body fluid. | 09-09-2010 |
20100236923 | Membrane System With Sufficient Buffering Capacity - Electrochemical sensors for measurement of an analyte comprising an analyte sensing membrane comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof. Sensor testing methods comprising contacting an electrochemical sensor with an aqueous solution comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof and contacting the electrochemical sensor with one or more concentrations of analyte, the one or more concentrations of analyte being in the clinical concentration range of the analyte. | 09-23-2010 |
20100243443 | Biosensor, thin film electrode forming method, quantification apparatus, and quantification method - A biosensor according to the present invention comprises a support | 09-30-2010 |
20100270151 | METHOD FOR MANUFACTURING AN ENZYMATIC REAGENT INK - A method for manufacturing an enzymatic reagent ink for use in analytical test strips (such as electrochemical-based analytical test strips configured for the determination of glucose in blood) includes determining a first relationship between wetability of a representative hydrophobic silica material (e.g., a hydrophobic fumed silica material) and at least a first calibration characteristic (for example, a calibration slope) of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In the method, the first relationship defines a minimum wetability that provides an acceptable first calibration characteristic. The method also includes determining a second relationship defining wetability of a mixture of a particular hydrophobic silica material and a particular surfactant across a range of relative amount of the particular hydrophobic silica material and the particular surfactant and, subsequently, combining an amount of the particular hydrophobic silica material, an amount of the particular surfactant, and an amount of enzyme (such as glucose oxidase) to form an enzymatic reagent ink. Moreover, the amounts of the particular hydrophobic silica material and the particular surfactant are predetermined based on the second relationship to provide at least the minimum wetability defined by the first relationship. | 10-28-2010 |
20100270152 | ENZYMATIC REAGENT INK - An enzymatic reagent ink includes an amount of hydrophobic silica material (e.g., a fumed silica material), an amount of surfactant (such as a non-ionic surfactant); and an amount of enzyme (for example, glucose oxidase). The amounts of the hydrophobic silica material and the surfactant present in the enzymatic reagent ink is predetermined based on first and second relationships. The first relationship is a relationship between wetability of a representative hydrophobic silica material and a first calibration characteristic of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In addition, such a first relationship defines a minimum wetability that provides an acceptable first calibration characteristic. The second relationship is a relationship defining wetability of a mixture of the hydrophobic silica material and a surfactant across a range of relative amounts of the hydrophobic silica material and the surfactant. The amounts of the hydrophobic silica material and the surfactant in the enzymatic reagent ink are predetermined to provide at least the minimum wetability defined by the first relationship during manufacturing of the enzymatic reagent ink, and therefore, an acceptable first calibration characteristic. | 10-28-2010 |
20100288634 | Transition Metal Complexes with Bidentate Ligand Having an Imidazole Ring - Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described. | 11-18-2010 |
20100294660 | Glucose Testing Device And Strips For Same - The present invention provides an electrochemical biosensor. The biosensor includes a substrate; a metal layer disposed on the substrate, wherein a first end of the metal layer is formed with a reaction region by a working electrode and a reference electrode provided on the metal layer, the reaction region is applied with an enzyme so that an electrical response is generated when the enzyme and a test sample form a chemical reaction, and a second end of the metal layer is provided with an integrated information unit to provide both test sample information and coding information. | 11-25-2010 |
20100314248 | RENEWABLE BIOELECTRONIC INTERFACE FOR ELECTROBIOCATALYTIC REACTOR - An inexpensive, easily renewable bioelectronic device useful for bioreactors, biosensors, and biofuel cells includes an electrically conductive carbon electrode and a bioelectronic interface bonded to a surface of the electrically conductive carbon electrode, wherein the bioelectronic interface includes catalytically active material that is electrostatically bound directly or indirectly to the electrically conductive carbon electrode to facilitate easy removal upon a change in pH, thereby allowing easy regeneration of the bioelectronic interface. | 12-16-2010 |
20110017595 | Biosensor Membranes Composed of Polymers Containing Heterocyclic Nitrogens - Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described. | 01-27-2011 |
20110031118 | BIOSENSOR - A biosensor for electrochemically measuring a sample may include a first member made of an insulating material, an electrode system including a working electrode and a counter electrode formed on the first member, a second member fixed over the first member, a sample flow channel provided between the first member and the second member, a hydrophilic section provided on at least a part of the internal surface of the sample flow channel and extending from a first end near the electrode system to a second end on the opposite side, and a flow stop area provided on a section adjacent to the second end on the first member or on the internal surface of the sample flow channel. | 02-10-2011 |
20110048940 | SMALL VOLUME TEST STRIPS WITH LARGE SAMPLE FILL PORTS, SUPPORTED TEST STRIPS, AND METHODS OF MAKING AND USING SAME - The present disclosure provides small volume analyte sensors having large sample fill ports, supported analyte sensors, analyte sensors having supported tip protrusions and methods of making and using same. | 03-03-2011 |
20110139617 | FUNCTIONAL LAYERS OF BIOMOLECULES AND LIVING CELLS, AND A NOVEL SYSTEM TO PRODUCE SUCH - The present invention concerns a new process for depositing a thick compact layer of biomolecules for instance such a layer with thickness in the μm scale and, for depositing a thick compact layer of cells in the μm scale. The deposited layer is made by application of an unbalanced (asymmetrical) alternating voltage polarization between two electrodes to a dissolved biomolecule or cell from low conductivity solutions. The process allows the rapid manufacturing of sensors and the coating of devices with functional cells and biomolecules. Examples are provided on the preparation of functional sensors such as a glucose, a lactose sensor, a hydrogen peroxide sensor and a glutamate sensor. Examples are also provided on the deposition of eukaryoric cells such as | 06-16-2011 |
20110147210 | Method and apparatus for processing electrochemical signals - Systems and methods are provided herein for improving the selectivity and productivity of sensors via digital signal processing techniques. According to one illustrative embodiment, in an electrochemical method for monitoring of a select analyte in a mixed sample with an interfering analyte, an improvement is provided that includes applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal; and resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte. | 06-23-2011 |
20110174614 | ELECTRODE, METHOD AND SYSTEM FOR DETERMINING AN ANALYTE IN A LIQUID MEDIUM - Disclosed is an electrode for determining an analyte in a liquid medium, such as glucose in body subcutaneous fluids. The electrode includes a conductive surface and a matrix bound thereto. The matrix includes at least two species of components that comprise one or more species of enzymes and one or more species of metal nanonparticle. The components may be covalently bound to one another through one or more first binding moieties and the matrix may be covalently bound to the conductive surface through one or more same or different second binding moieties. The one or more enzyme species can catalyze a reaction in which an analyte is reacted to yield a product. The catalysis may alter the electric properties or response of the electrode. | 07-21-2011 |
20110180404 | Biosensor - In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration. | 07-28-2011 |
20110186430 | BIOSENSOR AND METHODS FOR MANUFACTURING - A biosensor for detecting an analyte in a sample of body fluid and methods for manufacturing the biosensor are disclosed. In one embodiment, a biosensor includes at least two electrical conductors embedded within an electrically insulating test element body. The electrical conductors are exposed at two ends of the test element body and a reagent, for example a reagent adapted to test for blood glucose, is applied to one end. In one form, the test element body is cylindrical with a circular or non-circular cross-sectional shape. In other embodiments, the test elements are manufactured by a resin pultrusion process in which resin embedded with electrical conductors is dried or cured, shaped and cut into segments, and reagent applied to one end of each segment. | 08-04-2011 |
20110192721 | SYSTEM AND METHODS FOR AUTOMATICALLY RECOGNIZING A CONTROL SOLUTION - Methods and devices for automatically distinguishing between a control solution and an actual patient/user sample in a biosensor are provided. The solution is introduced into an electrochemical cell having a working and counter electrode. Electric pulses are applied to the cell and resultant signals are measured. Based on a comparison of the measured signals, a meter can determine whether the sample is a control solution or an actual patient/user sample. | 08-11-2011 |
20110198223 | METHOD FOR MEASURING BLOOD COMPONENTS AND BIOSENSOR AND MEASURING INSTRUMENT FOR USE THEREIN - The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrode | 08-18-2011 |
20110259741 | Biosensor - A biosensor includes a first working electrode that a biocatalyst, which has a property that reacts on a specified ground substance, is disposed, a second working electrode that the biocatalyst, which the property is lost, is disposed, and at least one counter electrode for respectively applying a voltage to the first working electrode and the second working electrode. | 10-27-2011 |
20110266150 | Biosensor Strip - The present invention discloses a biosensor strip, which comprises: a base plate layer defining a first strip end and a second strip end; a conductive layer being disposed on the base plate layer and partitioned into at least two electrode paths; a reagent containing layer being disposed on the conductive layer and comprising a first through hole that is located at the first strip end and for accommodating a reagent solution, wherein the reagent solution comprises matrix, redox mediator, enzyme, surfactant, and a buffer solution; a channel forming layer being disposed on the reagent containing layer and comprising a gap portion that is located at the first strip end; and a cover layer being disposed on the channel forming layer and comprising a second through hole that exposes the partial area of the gap portion of the channel forming layer. | 11-03-2011 |
20110297540 | Low Total Salt Reagent Compositions and Systems for Biosensors - A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ΔS value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one ΔS value, where the compensation equation has a R | 12-08-2011 |
20110303537 | Redox Polymers - Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described. | 12-15-2011 |
20110303538 | Redox Polymers - Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described. | 12-15-2011 |
20110308944 | Electrochemical Sensor and Method for Manufacturing Same - The present invention provides an electrochemical sensor comprising a substrate, an electrically conductive layer made of carbon particles which is disposed on the substrate, a cell membrane mimetic structure layer containing an enzyme at least one of inside the cell membrane mimetic structure layer and on the interface of the cell membrane mimetic structure layer which is disposed on the electrically conductive layer. | 12-22-2011 |
20110308945 | GENETIC ANALYSIS LOC DEVICE WITH THICK ELECTRODES FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES - A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence for forming probe-target hybrids, and an electrochemiluminescent (ECL) luminophore, electrodes for generating an excited state in the ECL luminophore in which the ECL luminophore emits photons of light, and, a photosensor for sensing the photons emitted from the ECL luminophore, wherein, the photosensor has a planar active surface area for receiving the light from the ECL luminophore and the electrodes are between 0.25 micron and 2 microns thick in a direction normal to the planar active surface area of the photodiodes. | 12-22-2011 |
20120018301 | NANOELECTRONIC ELECTROCHEMICAL TEST DEVICE - Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules. | 01-26-2012 |
20120018302 | BIOSENSOR UNIT AND BIOSENSOR SYSTEM - The biosensor unit has a substrate composed of a subcutaneously retained part that is retained under the skin and a base part that is placed on the skin surface. The biosensor unit comprises a sensor part detecting numerical information regarding a substance to be measured as electric signals, a signal amplifying part amplifying the electric signals, a CPU including a calculation part A/D converting the amplified electric signals and processing them to create transmittable data, a storage storing electric signals and data, a transmission part transmitting data to an external device through optical communication, and a battery part for drive. The sensor part is provided on the subcutaneously retained part and the transmission part is provided on the base part. | 01-26-2012 |
20120043204 | ENZYMATIC REAGENT INKS FOR USE IN TEST STRIPS HAVING A PREDETERMINED CALIBRATION CODE - The invention provides an enzyme ink useful in test strips that provides a test strip bias, at the low and high glucose ends, falling within a desired target range. The ink of the invention permits an improved method for the production of single calibration code strip lots with good yields. | 02-23-2012 |
20120125767 | Analyte Sensors and Methods of Use - Analyte sensors for determining the concentration of an analyte in a sample. The sensors have a sample chamber having an inlet with a projection extending from an edge of the sensor for facilitating flow of sample into the sample chamber. | 05-24-2012 |
20120132525 | REDOX POLYMERS FOR USE IN ANALYTE MONITORING - Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. | 05-31-2012 |
20120181173 | ELECTROCHEMICAL SENSOR FOR THE DETECTION OF ANALYTES IN LIQUID MEDIA - The invention relates to an electrochemical sensor for the detection of analytes in liquid media which comprises 4 layers, wherein the first layer (1) comprises a carbonaceous material deposited on a substrate, said layer forming the system of electrodes of the electrochemical sensor, formed at least by a pseudo-reference electrode, a working electrode and a counter electrode; and the fourth layer (4) comprises polythiophene deposited only on the lower end of the working electrode selected from (d1), which comprises a layer comprising a polythiophene deposited on the lower end of the working electrode and a layer comprising a non-conductive polymer gel deposited on said layer of polythiophene; (d2), which is a layer of conductive polymer gel comprising a non-conductive polymer gel and a polythiophene; and (d3), which comprises a layer comprising a polythiophene deposited on the lower end of the working electrode and a layer comprising functionalized magnetic nanoparticles deposited on said layer of polythiophene. | 07-19-2012 |
20120261258 | TEST STRIPS, METHODS, AND SYSTEM OF MANUFACTURING TEST STRIP LOTS HAVING A PREDETERMINED CALIBRATION CHARACTERISTIC - Various embodiments of a technique in which test strip lots can be prepared without requiring a user to input any calibration information before performing a test measurement with a test strip from the test strip lots. In a first aspect, a method of manufacturing a plurality of test strips by adjusting amount of mediators and working electrode area is described. In another aspect, a method of preparing a reagent ink by adjusting the density of the reagent ink to substantially match a target density is described. In a further aspect, a method using a high numerical Shores Hardness squeegee in conjunction with high pressure is provided. In a further aspect, a method of performing an analyte measurement with a test meter, the test meter being configured to not receive a calibration input, and where the test strip manufactured to any one of the methods or techniques described and illustrated herein. | 10-18-2012 |
20120261259 | Potentiometric Sensor and Analytical Element - A potentiometric sensor with suppressed leak current on the surface of an electrode and improved for a dynamic range and a response speed, in which a redox compound is immobilized through insulative molecules on the surface of a gold electrode, and a current between a source and drain of an insulated gate field-effect transistor along with reaction between an oxidized substance or a reduced substance produced by the reaction of a measured substance in a sample solution injector for supplying the sample solution containing the measured substance and an enzyme and a redox compound on the surface of the gold electrode, is monitored on real time to measure the change of the surface potential. | 10-18-2012 |
20120305395 | Device for the Determination of Glycated Hemoglobin - An electrochemical device for determining the percentage of glycated hemoglobin in a blood sample is provided. The device includes a cathode and anode and one or more cells. The device may include an enzyme capable of reducing oxygen to water for determining the total amount of hemoglobin in a sample by electrochemically measuring, in an oxygen electroreduction reaction at a cathode, the amount of oxygen in the sample. The device may also be used to determine the amount of glycated hemoglobin in the sample (e.g., spectrometrically or electrochemically). Also provided are devices that include glycated hemoglobin hydrolysis agents or glycated hemoglobin separating agents. | 12-06-2012 |
20120305396 | Electrochemical Cell and Method of Making an Electrochemical Cell - Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet. | 12-06-2012 |
20120325658 | DETECTION DEVICE - A detection device that is used to detect a sample includes: a base component having on its surface a sample supply position to which the sample is supplied; an electrode system formed at a distance from the sample supply position on the surface of the base component; a sliding component having a slide body that performs a sliding movement over the surface of the base component, a sample receptacle portion provided in a portion of the slide body; and a supporting portion that is fixed to the base component and supports the sliding component such that it can perform the sliding movement relative to the base component. The base and the sliding components can perform the sliding movement within a range that includes an overlap position, where the sample receptacle portion overlaps with the electrode system, and the sample supply position. | 12-27-2012 |
20130015063 | DEVICE FOR MEASURING SUBSTRATE CONCENTRATION - The present invention provides a method for measuring a substrate concentration by accumulating an energy resulting from a reaction between a biocatalyst and a substrate recognized by the biocatalyst to a certain level; and using a dependency of an accumulation rate on the substrate concentration as an index; and a apparatus therefor. In particular, the present invention provides a method in which the measurement of the accumulation rate is carried out by measuring a frequency of an energy release in a certain amount of time when the energy accumulated in the capacitor reaches the certain level and is then released. | 01-17-2013 |
20130020196 | BIOSENSOR - To provide a biosensor capable of measuring the concentration of specific component, such as glucose or neutral fat, in sample in a short time. | 01-24-2013 |
20130062201 | Glucose Sensor Having Titanium Dioxide-Graphene Composite - Provided is a glucose sensor including a titanium dioxide-graphene composite having a porous structure. More particularly, the glucose sensor includes a working electrode having the titanium dioxide-graphene composite having the porous structure and an enzyme to provide features that allow a current flow to be excellent, a current to be sensitively changed depending on a change in electric potential, sensitivity to be high, and a low voltage characteristic to be excellent. | 03-14-2013 |
20130098763 | SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE - Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error. | 04-25-2013 |
20130126350 | Mediator For Test Sensor - A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator. | 05-23-2013 |
20130153416 | MICROFLUIDIC DEVICE - A microfluidic device includes a micro-channel that defines a plane. A plurality of drive electrodes is located on a first side of the plane. At least one ground electrode is operable to establish an electric potential with the plurality of drive electrodes. An array of electrochemical biosensors is located on a second, opposite side of the plane. | 06-20-2013 |
20130186755 | Biosensor Desiccant System Having Enhanced Measurement Performance - A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%. | 07-25-2013 |
20130192987 | BIOSENSOR AND METHOD FOR PRODUCING THE SAME - A biosensor according to the present invention includes a first base material having an insulating surface; an adhesive layer located on the insulating surface of the first base material; and an electrode system and wiring sections fixed to the first base material via the adhesive layer. The electrode system includes top electrode layers and bottom electrode layers, and the bottom electrode layers are formed of a material having a higher conductivity than that of the top electrode layers; the electrode system includes a working electrode and a counter electrode, and also includes an enzyme reaction section located on the working electrode, the enzyme reaction section containing an enzyme and an electron acceptor; and the bottom electrode layers and the wiring sections are integral with each other. | 08-01-2013 |
20130334042 | PATHOGEN SENSOR - A pathogen sensor comprising a growth medium upon which and/or within which a pathogen may grow, the growth medium comprising nutrients which facilitate growth of the pathogen, wherein the pathogen sensor further comprises an electronic detection apparatus configured to detect an electrochemical change mediated by the pathogen. | 12-19-2013 |
20130341186 | Test Strip and Detecting Device - A test strip and a detecting device are disclosed. The test strip can be used with an electrochemical instrument to accurately detect the viscosity and concentration of an analyte of a specimen. The test strip includes a first specimen path, a first electrode set, a redox reagent, a second specimen path, a second electrode set, and a reaction reagent. The redox reagent includes at least a redox pair. When the specimen enters the first specimen path, the redox pair dissolves and generates an electrochemical redox reaction for obtaining a flow time of the specimen. When the specimen enters the second specimen path, the reaction reagent is used to obtain the analyte concentration of the specimen, and the concentration of the analyte can be corrected by the flow time. | 12-26-2013 |
20140001045 | Electrochemical Assay Device and Related Methods | 01-02-2014 |
20140008219 | BIOSENSOR STRIP - A biosensor strip with improved sample area design is disclosed, in which a specimen flowing in a flow channel is siphoned into another flow channel which has two hydrophilic layers attached to two respective sides of the same for enhancing the siphoning of the specimen. In an embodiment, by the doping of a hydrophilic material into an enzyme layer of the biosensor strip, the specimen that is being siphoning rapidly is able to mixed with the enzyme fully so as to enhance the measurement accuracy of a biological instrument using the biosensor strip. | 01-09-2014 |
20140021046 | ELECTRODE STRIP AND SENSOR STRIP AND MANUFACTURE METHOD THEREOF AND SYSTEM THEREOF - The present disclosure relates to an electrode strip, a sensor strip, a system thereof and a manufacturing method thereof. The sensor strip includes a first reactive film, a second reactive film and a vent hole. The first reactive film includes a substrate, a first electrode layer and a first insulation layer. The first end of the first insulation layer is concaved to a first depth to form a first reactive area. The second reactive film includes a second electrode layer and a second insulation layer. The first end of the second insulation layer is concaved to a second depth to form a second reactive area. The vent hole penetrates the second insulation layer, the second electrode layer and the first insulation layer so as to connect the first reactive area and the second reactive area. | 01-23-2014 |
20140027280 | FAD-CONJUGATED GLUCOSE DEHYDROGENASE GENE - Disclosed herein are a gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase which can be characterized by reactivity to glucose, thermal stability, substrate-recognition performance, and low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; a method for the determination of glucose; a reagent composition for use in the determination of glucose; and a biosensor for use in the determination of glucose. An embodiment is a polynucleotide encoding an FAD-conjugated glucose dehydrogenase, comprising a polypeptide whose amino acid sequence comprises X1-X2-X3-X4-X5-X6, wherein X1 and X2 independently represent an aliphatic amino acid residue; X3 and X6 independently represent a branched amino acid residue; and X4 and X5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue. | 01-30-2014 |
20140054171 | Analyte Sensor Utilizing Oxygen as Oxidant - An analyte sensor configured to utilize oxygen as an oxidant and method for manufacturing and using the same are provided. The analyte sensor includes a catalyst to facilitate use of oxygen as oxidant. The catalyst may be provided on an electrode of the analyte sensor. | 02-27-2014 |
20140061045 | ELECTROCHEMICAL TEST SENSOR AND METHOD OF FORMING THE SAME - A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern. | 03-06-2014 |
20140102896 | ELECTRON TRANSFER MEDIATORS FOR ENZYME-BASED BIOSENSOR - A new ferrous complex capable of being used as an electron transfer mediator for a glucose sensor, a biosensor, and the like, is provided, which measure a glucose concentration in blood, in which the new ferrous complex exchanges rapidly and smoothly an electron between an enzyme and electrode, is strongly absorbed into electrode, and is stable, so that the new ferrous complex allows excellent sensitivity of a glucose sensor to be maintained. | 04-17-2014 |
20140158534 | BIOSENSOR, THIN FILM ELECTRODE FORMING METHOD, QUANTIFICATION APPARATUS, AND QUANTIFICATION METHOD - A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition. | 06-12-2014 |
20140174922 | ELECTROCHEMICAL TEST SENSOR - An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample. | 06-26-2014 |
20140202853 | Small Volume Test Strips with Large Sample Fill Ports, Supported Test Strips, and Methods of Making and Using Same - The present disclosure provides small volume analyte sensors having large sample fill ports, supported analyte sensors, analyte sensors having supported tip protrusions and methods of making and using same. | 07-24-2014 |
20140202854 | Measurement Method Using Oxidase - A method for measuring a target object in a sample by using an oxidase, wherein the influence of dissolved oxygen in the sample can be corrected, is provided. The method comprises: obtaining measurement values by causing the target object in the sample to react with the oxidase under different conditions of two or more types; and performing a correction based on the obtained two or more measurement values and a correction method preliminarily set so as to correct the influence of dissolved oxygen in the sample. | 07-24-2014 |
20140209460 | Biosensor Systems for Determining Analyte Concentration Based on Complex Index Functions - A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals or determined analyte concentrations with one or more complex index function extracted from the output signals or from other sources. The complex index functions determine at least one slope deviation value, ΔS, or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias. | 07-31-2014 |
20140216931 | Electron-Conducting Crosslinked Polyaniline-Based Redox Hydrogel, and Method of Making - A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose. | 08-07-2014 |
20140262776 | BIOSENSOR WITH IMPROVED INTERFERENCE CHARACTERISTICS - This invention relates to mutagenized redox oxidase enzymes used to design enzyme electrodes with improved interference characteristics in the presence of mediator and oxygen in the assay. This recombinant modified enzyme has enhanced capability to transfer electrons to redox mediator instead of its natural electron acceptors such as O | 09-18-2014 |
20140262777 | BIOSENSOR STRUCTURES FOR IMPROVED POINT OF CARE TESTING AND METHODS OF MANUFACTURE THEREOF - The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of care electrochemical biosensors for testing for creatinine in samples. For example, the present invention may be directed to a biosensor having an electrode, a first printed layer formed on the electrode and having a first matrix that includes creatinine amidohydrolase (CNH), creatine amidinohydrolase (CRH), and sarcosine oxidase (SOX), and second printed layer formed over the first printed layer and having a second matrix that includes CRH, SOX, and catalase. | 09-18-2014 |
20140262778 | Electrochemical Cell and Method of Making an Electrochemical Cell - Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet. | 09-18-2014 |
20140299467 | Analyte Sensors and Methods of Use - Analyte sensors for determining the concentration of an analyte in a sample. The sensors have a sample chamber having an inlet with a projection extending from an edge of the sensor for facilitating flow of sample into the sample chamber. | 10-09-2014 |
20140305796 | METHODS AND SYSTEMS FOR MEASUREMENT OF TEAR GLUCOSE LEVELS - A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample. | 10-16-2014 |
20140326600 | CARBON NANOSTRUCTURE ELECTROCHEMICAL SENSOR AND METHOD - Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Carbon nanostructures functionalized using such a layer-by-layer method may be used to disperse, sort, separate and purify carbon nanostructures and may be used as sensing elements such as voltammetric, amperometric, and potentiometric pH sensors or as biometric sensing elements and electrodes and intracorporeal sensors and electrodes. | 11-06-2014 |
20140339078 | GLUCOSE SENSOR INCLUDING NOBLE METAL-GRAPHENE COMPOSITES - Provided is a glucose sensor. The glucose sensor according to the present invention includes noble metal-graphene composites, and has high sensitivity and significantly excellent current flow as compared to titanium dioxide-graphene composites. In addition, the noble metal-graphene composite manufactured by aerosol spray pyrolysis serves as an improved glucose sensor having desirable sensitivity, stability, reproducibility, and selectivity. | 11-20-2014 |
20140353154 | NANOELECTRONIC ELECTROCHEMICAL TEST DEVICE - Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules. | 12-04-2014 |
20140360873 | BLOOD ANALYSIS METER - A meter configured to perform a blood analysis is presented where the meter has a housing, the housing having an aperture configured to receive a body part of a user. The meter also having a plurality of light sources supported by the housing and a controller configured to control the plurality of light sources to indicate an operational status of the apparatus. | 12-11-2014 |
20150014161 | CONCENTRATION MEASURING DEVICE - A concentration measuring device having a spot-application region, and a configuration capable of measuring the concentration of an object component in the sample liquid dropped on the spot-application region, the concentration measuring device including: a light irradiation device, which is provided on a side below the spot-application region, for emitting an irradiation light having a wavelength absorbable by a coloring matter in the dropped sample liquid. The irradiation light passes through the spot-application region, thereby the sample liquid dropped on the spot-application region is irradiated with the irradiation light from the side below the spot-application region. As a result, a non-covered region in the spot-application region can be easily found by visual observation. The spot-application region is composed of, for example, a through hole formed on the supporting film and a separation membrane that blocks the through hole. | 01-15-2015 |
20150014162 | CONNECTOR FOR CONNECTING BIO-SENSOR AND MEASURING INSTRUMENT THEREOF - Disclosed herein is a connector for connecting a biosensor and a measuring device thereof. The connector includes an insertion guide to prevent a connection electrode from being damaged due to a mis-insertion of the biosensor when the biosensor is inserted into the connector, and also may further include an integrated photo reflector for emitting and detecting an infrared ray to identify production lot information of the biosensor, so that production information of the biosensor may be simply opened, and as a result, the connector may be used as a connector for connecting the biosensor and the measuring device thereof. | 01-15-2015 |
20150027886 | BIOSENSOR - Provided is a technique capable of suppressing reduction of a mediator in a stored state. A reagent layer (an enzyme layer | 01-29-2015 |
20150047978 | BIOSENSOR HAVING NANOSTRUCTURED ELECTRODES - The present invention provides a substrate for a microfluidic device comprising a polymeric base plate, at least one sensor formed over the polymeric base plate for detecting at least one target analyte from a sample, the sensor comprising at least one reference electrode and at least one working electrode, wherein a plurality of nanostructures deposited over the working electrode for increasing the surface area of the working electrode, and at least one recognition element bound to or deposited over the nanostructures. The microfluidic device of the present invention is a point-of-care, self calibrated, self contained hand-held device for rapid screening and diagnosis of various disease markers. | 02-19-2015 |
20150053559 | BIOSENSOR, BIOSENSOR CHIP AND BIOSENSOR DEVICE - A biosensor includes a working electrode | 02-26-2015 |
20150053560 | BIOSENSOR, BIOSENSOR CHIP AND BIOSENSOR DEVICE - A biosensor includes a working electrode | 02-26-2015 |
20150090590 | Cationic Polymer Based Wired Enzyme Formulations for Use in Analyte Sensors - Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring. | 04-02-2015 |
20150101929 | REAGENT COMPOSITION FOR REDOX REACTION - The present invention relates to a stabilizing composition useful for improving the stability of reagent for redox reaction, and a reagent composition for redox reaction having an improved stability. The reagent composition for redox reaction can be applied for a reagent for electrochemical biosensor. | 04-16-2015 |
20150107994 | BIOSENSOR - A biosensor is provided. The biosensor includes a lower substrate including an electrode unit, an insulation layer disposed on the lower substrate, a first spacer layer disposed on the insulation layer over the electrode unit, an enzyme unit disposed on the first spacer layer, a second spacer layer disposed on the enzyme unit, such that the enzyme unit is interposed between the first and second spacer layers, and an upper substrate disposed on the second spacer layer. The electrode unit includes a working electrode, and a reference electrode and a counter electrode that surround a periphery of the working electrode, facing the working electrode. | 04-23-2015 |
20150122645 | ENZYME MATRICES FOR BIOSENSORS - Embodiments of the invention provide analyte sensors formed from layered materials that include polymeric enzyme compositions selected to provide advantageous material properties, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes. | 05-07-2015 |
20150122646 | Mediator-less Electrochemical Glucose Sensing Procedure Employing the Leach-proof Covalent Binding of an Enzyme(s) to Electrodes and Products Thereof - The present disclosure generally relates to devices and procedures for the development of glucose oxidase-bound electrodes by a covalent binding of glucose oxidase on amine-functionalized electrodes. More particularly, the present disclosure is related to covalently-bound enzyme-coated electrodes that are leach-proof and highly stable for continuous glucose monitoring. The glucose oxidase-bound electrodes are employed for the development of a mediator-less electrochemical glucose sensing procedure having no interference from biological substances and drugs. | 05-07-2015 |
20150122647 | ENZYME MATRICES FOR USE WITH ETHYLENE OXIDE STERILIZATION - The invention pertains to analyte sensors designed to include layered compositions that provide these sensors with enhanced functional and/or material properties including, for example, resistance to damage caused by ethylene oxide during sterilization processes. Embodiments of the invention include polyvinyl alcohol N-methyl-4(4′-formylstyryl)pyridinium (SbQ) polymer materials and methods for employing such materials during the ethylene oxide sterilization of glucose sensors. | 05-07-2015 |
20150129425 | Enzyme Electrode - An enzyme electrode includes an electrode, and a detection layer that is in contact with the electrode and includes an oxidoreductase, a water-soluble conductive polymer, and conductive particles, electrons being transferred between the enzyme and the electrode by direct electron transfer in the detection layer. | 05-14-2015 |
20150136599 | SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES - Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample. | 05-21-2015 |
20150322475 | ELECTRODE FOR URIC ACID AND METHOD OF PRODUCING THE SAME - Embodiments of this invention disclose new second generation uric acid-sensing electrodes at least characterized by chemically bonding both uricase and the redox mediator to an electrode. The produced electrodes can be long-term stably used without losing activity. The developed electrode has been successfully applied for the analysis of uric acid (UA) in healthy human urine specimens which exhibits very good analysis accuracy and precision without too much interference. Therefore, the developed electrodes have the potential for clinical applications. | 11-12-2015 |
20150327801 | Analyte Sensors Comprising High-Boiling Point Solvents - Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a high-boiling point solvent, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 11-19-2015 |
20150355130 | Biosensors and Methods of Preparing Same - A biosensor strip having a low profile for reducing the volume of liquid sample needed to perform an assay. In one embodiment, the biosensor strip includes an electrode support; an electrode arrangement on the electrode support; a cover; a sample chamber; and an incompressible element placed between the cover and the electrode support, the incompressible element providing an opening in at least one side or in the distal end of the sample chamber to provide at least one vent in the sample chamber. In another embodiment, the biosensor strip has an electrode support; an electrode arrangement on the electrode support; a cover; and a sample chamber, the cover having a plurality of openings formed therein, at least one of the openings in register with the sample chamber. The invention further includes methods for preparing such a biosensor strips in a continuous manner. | 12-10-2015 |
20150368688 | METHOD OF MAKING AN ELECTROCHEMICAL SENSOR STRIP - A method of making an electrochemical sensor strip that includes: depositing a first electrode on a base; depositing a second electrode on the base; applying a first layer onto the first electrode; and applying a second layer onto the second electrode. The first layer includes an oxidoreductase and a mediator. The second layer includes a soluble redox species. | 12-24-2015 |
20150369770 | BIOSENSOR AND METHOD FOR MANUFACTURING SAME - The present invention provides a biosensor capable of measuring various blood components, in particular, the concentration of blood glucose with high accuracy even when a hematocrit level varies. The above-described object was achieved by a biosensor | 12-24-2015 |
20160017399 | ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH ENZYMATIC REAGENT LAYER CONTAINING A NAPHTHOQUINONE-BASED MEDIATOR AND FAD-GDH - An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, an electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer, and a top layer. Moreover, the enzymatic reagent layer includes at least one naphthoquinone-based mediator. The naphthoquinone-based mediator can, for example, be at least one of 1,2-naphthalenedione-4-(3-mercapto-1-propane sulfonic acid) and 1,2-naphthalenedione-4-(3-mercaptopropionic acid); and FAD-GDH enzyme. | 01-21-2016 |
20160025674 | LIQUID SAMPLE MEASUREMENT DEVICE, LIQUID SAMPLE MEASUREMENT METHOD, AND BIOSENSOR - It is intended to provide, for example, a liquid sample measurement device capable of measuring the amounts of components of a liquid with a high accuracy. A first voltage is applied to an electrode pair | 01-28-2016 |
20160054252 | Electrochemical Biosensor - Provided is a biosensor having i) sufficient sensitivity allowing quantitative detection of a low concentration of an analyte; and ii) excellent selectivity allowing selective distinction of the presence of an analyte. | 02-25-2016 |
20160054255 | CONCENTRATION DETERMINATION IN A DIFFUSION BARRIER LAYER - The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced. | 02-25-2016 |
20160061764 | SENSOR AND CONCENTRATION MEASUREMENT METHOD - A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor. | 03-03-2016 |
20160077034 | BIOSENSOR - A biosensor includes a flexible foil with an electrode layer positioned on the foil. An adhesive layer is positioned on the foil layer, and a first photo-definable hydrogel membrane is positioned over the electrode layer and the adhesive layer. A second photo-definable hydrogel membrane with an immobilized bio-recognition element is positioned over the first hydrogel membrane in contact with the electrode layer through an opening in the first hydrogel membrane. | 03-17-2016 |
20160084790 | Biosensor Desiccant System Having Enhanced Measurement Performance - A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%. | 03-24-2016 |
20160084792 | ELECTROCHEMICAL TEST SENSOR - The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 μg/mm | 03-24-2016 |
20160103096 | BIOCHEMICAL TEST CHIP AND METHOD FOR MANUFACTURING THE SAME - Provided is a biochemical test chip including an insulating substrate, an electrode unit, a first insulating septum, a reactive layer and a second insulating septum. The insulating substrate has a first vent hole. The electrode unit is located on the insulating substrate. The first insulating septum is located on the electrode unit. The first insulating septum has an opening which exposes a part of the electrode unit. The reactive layer is located in the opening. The second insulating septum is located on the first insulating septum. The second insulating septum has a second vent hole. The first vent hole is at least partially overlapped with the second vent hole. | 04-14-2016 |
20160109400 | SENSOR FOR DETECTING GLUCOSE OF RHIZOME PLANTS - A sensor for detecting glucose of rhizome plants comprises a substrate, an electrode module, a hydrophobic insulating layer and a cover. The electrode module is arranged on the substrate and includes a measurement portion and a connection section connected with the measurement portion. The hydrophobic insulating layer is disposed on the substrate to cover the measurement portion and the connection section and includes an opening revealing the measurement portion. The cover is disposed on the opening to form a specimen channel between the cover and the substrate. The measurement portion is arranged in the specimen channel. The electrode module includes a working electrode and a reference electrode opposite to the working electrode. The measurement portion of the working electrode has a first exposed region with an area of 4-6 mm | 04-21-2016 |
20160178558 | SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES | 06-23-2016 |
20160186230 | Enzyme Electrode - The present invention provides an enzyme electrode comprising: an electrode; and a detection layer which is in contact with the electrode, where the detection layer includes an enzyme, a crosslinking agent, an electrically conductive polymer and a sugar, wherein electrons are transferred between the enzyme in the detection layer and the electrode. | 06-30-2016 |
20160195490 | BIOSENSOR | 07-07-2016 |
20160252476 | Electron-Conducting Crosslinked Polyaniline-Based Redox Hydrogel, and Method of Making | 09-01-2016 |
20170234824 | BIOLOGICAL INFORMATION MEASUREMENT DEVICE, AND BIOLOGICAL INFORMATOIN MEASUREMENT METHOD USING SAME | 08-17-2017 |
20170234825 | HIGH THROUGHPUT BIOCHEMICAL DETECTION USING SINGLE MOLECULE FINGERPRINTING ARRAYS | 08-17-2017 |
20180024086 | SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES | 01-25-2018 |