Zhengzhou University Patent applications |
Patent application number | Title | Published |
20150051403 | Use of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus - Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage. | 02-19-2015 |
20140187627 | USES OF C15-SUBSTITUTED ANDROGRAPHOLIDE DERIVATIVES IN THE PREPARATION OF ANTI-HEPATITIS B VIRUS MEDICAMENT - Disclosed is a use of C15-substituted andrographolide derivatives in preparation of anti-hepatitis B virus medicaments. In the present invention, the HepG2.2.15 cells are used to measure the amount of the hepatitis B virus surface antigen (HBsAg) secretion in the supernatant of the culture; the duck hepatitis B virus (DHBV) is used to infect the model and the DHBV-DNA level in serum is measured, and the pathological change in hepatic tissue is observed. A number of andrographolide derivative compounds are screened, compounds having a good anti-HBV effect are preferred, which has a structure represented by general formula 1 set forth herein. Due to high anti-HBV activity and low toxicity, as well as good protection against hepatic injury, the compounds can be used as the active ingredient for preparing anti-HBV medicaments, thereby providing a new pharmaceutical way for treatment of hepatitis, and broadening the range of clinical medicines. | 07-03-2014 |
20130237596 | Uses of 15-benzylidene-14-deoxy-11,12-didehydroandrographolide Derivatives in the Preparation of Antineoplastic Drugs - The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity. Thereby it has potential to expand the selectable range of clinical drug and is of high significance to make full use of the plant resources of | 09-12-2013 |
20100228014 | NOVEL ENT-KAURENE DITERPENE COMPOUND AND ITS DERIVATIVES, THEIR PREPARATION AND THEIR USE - Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives. | 09-09-2010 |